Aliases for NOS1 Gene
External Ids for NOS1 Gene
Previous HGNC Symbols for NOS1 Gene
Previous GeneCards Identifiers for NOS1 Gene
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
GeneCards Summary for NOS1 Gene
NOS1 (Nitric Oxide Synthase 1) is a Protein Coding gene. Diseases associated with NOS1 include Achalasia, Familial Esophageal and Impotence. Among its related pathways are Ibuprofen Pathway, Pharmacodynamics and Innate Immune System. GO annotations related to this gene include oxidoreductase activity and iron ion binding. An important paralog of this gene is NOS3.
UniProtKB/Swiss-Prot for NOS1 Gene
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
Neuronal nitric oxide synthase (nNOS), with inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS), catalyzes nitric oxide and L-citrulline generation from L-arginine and molecular oxygen. nNOS is activated at calcium concentrations over 100 nM.