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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOS1 Gene

protein-coding   GIFtS: 72
GCID: GC12M117636

Nitric Oxide Synthase 1 (Neuronal)


(Previous symbol: NOS)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nitric Oxide Synthase 1 (Neuronal)1 2     bNOS2 3
NOS1 2     nNOS2 3
Constitutive NOS2 3     NOS Type I2 3
Neuronal NOS2 3     EC 1.14.13.393 8
Peptidyl-Cysteine S-Nitrosylase NOS12 3     IHPS12
N-NOS2 3     Nitric Oxide Synthase, Brain2
NC-NOS2 3     

External Ids:    HGNC: 78721   Entrez Gene: 48422   Ensembl: ENSG000000892507   OMIM: 1637315   UniProtKB: P294753   

Export aliases for NOS1 gene to outside databases

Previous GC identifers: GC12M116666 GC12M117169 GC12M117431 GC12M116060 GC12M116111 GC12M114660


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOS1 Gene:
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide
from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes,
including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous
system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity
associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis,
and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle.
Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length
nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding
different isoforms (some testis-specific) have been found for this gene.(provided by RefSeq, Feb 2011)

GeneCards Summary for NOS1 Gene: 
NOS1 (nitric oxide synthase 1 (neuronal)) is a protein-coding gene. Diseases associated with NOS1 include pyloric stenosis, and hypertrophic pyloric stenosis, and among its related super-pathways are Parkinson's disease and cGMP effects. GO annotations related to this gene include calmodulin binding and heme binding. An important paralog of this gene is NOS3.

UniProtKB/Swiss-Prot: NOS1_HUMAN, P29475
Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In
the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has
nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR

summary for NOS1 Gene:
Neuronal nitric oxide synthase (nNOS), along with inducible nitric oxide synthase (iNOS) and endothelial
nitric oxide synthase (eNOS), catalyze the generation of nitric oxide and L-citrulline from L-arginine and
molecular oxygen. It is activated at concentrations of calcium greater than 100 nM and requires co-factors
of tetrahydrobiopterin, flavin adenine dinucleotide, flavin mononucleotide and NADPH for catalytic activity.
Transcriptional regulation of nNOS is very complex and the nNOS gene produces multiple mRNA transcripts
using alternate promoters, alternative splicing, cassette insertions/deletions, and varied sites for 3'-UTR
cleavage and polyadenylation. Some of these alterations lead to variation in amino acid sequence,
translating into nNOS isoforms with altered structural and functional properties. nNOS has been implicated
in a wide variety of physiological and pathological processes, including neurotransmission, neurotoxicity,
skeletal muscle contraction, sexual function, body fluid homeostasis and atherosclerosis. Consistent with
such wide involvement, nNOS is expressed in numerous tissues. The human gene encoding nNOS is localized to
chromosome 12q14.

Gene Wiki entry for NOS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOS1 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   STAT5A   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.22   Ensembl cytogenetic band:  12q24.22   HGNC cytogenetic band: 12q24.22

NOS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOS1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M117636:  view genomic region     (about GC identifiers)

Start:
117,645,947 bp from pter      End:
117,889,975 bp from pter
Size:
244,029 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOS1_HUMAN, P29475 (See protein sequence)
Recommended Name: Nitric oxide synthase, brain  
Size: 1434 amino acids; 160970 Da
Cofactor: Heme group
Cofactor: Binds 1 FAD
Cofactor: Binds 1 FMN
Cofactor: Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme
Subunit: Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1
and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts
with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with HTR4.
Interacts with VAC14 (By similarity). Interacts with SLC6A4 (By similarity)
Subcellular location: Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By
similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by
associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity)
Secondary accessions: E9PH30 O75713
Alternative splicing: 5 isoforms:  P29475-1   P29475-2   P29475-3   P29475-4   P29475-5   

Explore the universe of human proteins at neXtProt for NOS1: NX_P29475

Explore proteomics data for NOS1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro) (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P29475

  • 4/38 DME Specific Peptides for NOS1 (P29475) (see all 38)
     VLEEFPS  GWYMGTE  LDITTPP  VFGLGSR 

    NOS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOS1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_000611.1  NP_001191142.1  NP_001191143.1  NP_001191147.1  

    ENSEMBL proteins: 
     ENSP00000320758   ENSP00000337459   ENSP00000339862  
    Reactome Protein details: P29475
    Human Recombinant Protein Products for NOS1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for NOS1
    OriGene Purified Protein for NOS1
    OriGene Protein Over-expression Lysate for NOS1
    OriGene MassSpec for NOS1 
    OriGene Custom Protein Services for NOS1
    GenScript Custom Purified and Recombinant Proteins Services for NOS1
    Novus Biologicals NOS1 Proteins
    Novus Biologicals NOS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOS1 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001917photoreceptor inner segment ISS17027776
    GO:0005737cytoplasm TAS17892502
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ISS7545544
    GO:0016529sarcoplasmic reticulum IDA9892689

    NOS1 for ontologies           About GeneDecksing



    NOS1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NOS1
    R&D Systems Antibodies for NOS1 (nNOS)
    Cell Signaling Technology (CST) Antibodies for NOS1  (nNOS)
    OriGene Antibodies for NOS1
    OriGene Custom Antibody Services for NOS1
    GenScript Custom Superior Antibodies Services for NOS1
    Novus Biologicals NOS1 Antibodies
    Abcam antibodies for NOS1
    Cloud-Clone Corp. Antibodies for NOS1 
    ThermoFisher Antibody for NOS1
    LSBio Antibodies in human, mouse, rat for NOS1 

    Assay Products for NOS1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NOS1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NOS1
    Enzo Life Sciences assays for NOS1
    Cloud-Clone Corp. ELISAs for NOS1 
    Cloud-Clone Corp. CLIAs for NOS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Neuronal NOS 
    Nitric oxide synthases

    5/12 InterPro protein domains (see all 12):
     IPR026009 NOS
     IPR017927 Fd_Rdtase_FAD-bd
     IPR001094 Flavdoxin
     IPR008254 Flavodoxin/NO_synth
     IPR001433 OxRdtase_FAD/NAD-bd

    Graphical View of Domain Structure for InterPro Entry P29475

    ProtoNet protein and cluster: P29475

    5/6 Blocks protein domains (see all 6):
    IPB001094 Flavodoxin signature
    IPB001433 Oxidoreductase FAD/NAD(P)-binding
    IPB001478 PDZ/DHR/GLGF domain
    IPB001709 Flavoprotein pyridine nucleotide cytochrome reductase signature
    IPB003097 FAD-binding


    UniProtKB/Swiss-Prot: NOS1_HUMAN, P29475
    Domain: The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction,
    and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By
    similarity)
    Similarity: Belongs to the NOS family
    Similarity: Contains 1 FAD-binding FR-type domain
    Similarity: Contains 1 flavodoxin-like domain
    Similarity: Contains 1 PDZ (DHR) domain


    NOS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOS1_HUMAN, P29475
    Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In
    the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has
    nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR
    Catalytic activity: 2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O
    Enzyme regulation: Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent
    the dimerization of the protein. Inhibited by NOSIP

         Genatlas biochemistry entry for NOS1:
    nitric oxide synthase 1,constitutive by expressed,neuronal,putative susceptibility gene for infantile pyloric
    stenosis,widely expressed with a high expression in skeletal muscle

         Enzyme Number (IUBMB): EC 1.14.13.391 2

         Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003958NADPH-hemoprotein reductase activity IBA--
    GO:0004517nitric-oxide synthase activity ISS--
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI11149895
    GO:0005516calmodulin binding IEA--
         
    NOS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NOS1:
     Decreased viability after Chla 

         15/21 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nos1) (see all 21):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  muscle  nervous system  normal 

    NOS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NOS1: Nos1tm1Plh Nos1tm1Enik Nos1tm2Plh

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NOS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOS1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOS1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOS1
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate NOS1 (see all 74):
    hsa-miR-4254 hsa-miR-146a hsa-miR-15a hsa-miR-938 hsa-miR-371-5p hsa-miR-502-3p hsa-miR-149 hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidNOS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NOS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOS1
    Sirion Biotech Customized adenovirus for overexpression of NOS1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NOS1 (see all 7)
    OriGene ORF clones in mouse, rat for NOS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): NOS1 (NM_000620)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOS1
    Sirion Biotech Customized lentivirus for stable overexpression of NOS1 
                         Customized lentivirus expression plasmids for stable overexpression of NOS1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NOS1
    Search LifeMap BioReagents cell lines for NOS1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NOS1 About   (see all 33)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Alzheimers Disease0.44
    2Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase0.75
    Platelet homeostasis0.34
    3Insulin receptor recycling
    Latent infection of Homo sapiens with Mycobacterium tuberculosis0.64
    Phagosomal maturation (early endosomal stage)0.64
    4glutamine degradation I
    superpathway of citrulline metabolism0.50
    citrulline-nitric oxide cycle0.43
    5Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR21.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NOS1
        Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NOS1 (see all 9)
        Cellular Effects of Sildenafil
    Muscular Dystrophies and Dystrophin-Glycoprotein Complex
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Sertoli-Sertoli Cell Junction Dynamics
    Endothelin-1 Signaling Pathway

    2 Cell Signaling Technology (CST) Pathways for NOS1
        Neuroscience
    PI3K / Akt Signaling

    3 GeneGo (Thomson Reuters) Pathways for NOS1
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2
    NO-dependent CFTR activation (normal and CF)

    5/6 BioSystems Pathways for NOS1 (see all 6)
        Myometrial Relaxation and Contraction Pathways
    Spinal Cord Injury
    Monoamine Transport
    Alzheimers Disease
    citrulline-nitric oxide cycle

    5/6        Reactome Pathways for NOS1 (see all 6)
        Hemostasis
    Phagosomal maturation (early endosomal stage)
    Latent infection of Homo sapiens with Mycobacterium tuberculosis
    Platelet homeostasis
    Nitric oxide stimulates guanylate cyclase

    2 PharmGKB Pathways for NOS1
        Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics

    5/9         Kegg Pathways  (Kegg details for NOS1) (see all 9):
        Arginine and proline metabolism
    Metabolic pathways
    Calcium signaling pathway
    Phagosome
    Circadian entrainment


    NOS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for NOS1 (P294752, 3 ENSP000003207584) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAC14Q08AM62, 3, ENSP000002617764MINT-3999924 MINT-3999953 MINT-3999982 MINT-3999902 MINT-3999876 I2D: score=3 STRING: ENSP00000261776
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    ADRA1AP353483, ENSP000003699604I2D: score=2 STRING: ENSP00000369960
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEP16276418
    GO:0002028regulation of sodium ion transport ----
    GO:0006527arginine catabolic process IC7545544
    GO:0006809nitric oxide biosynthetic process ISS7545544
    GO:0006941striated muscle contraction IEA--

    NOS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NOS1 for compounds           About GeneDecksing

    EMD Millipore small molecules for NOS1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for NOS1

    Compounds for NOS1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    3-Bromo-7-nitroindazoleSelective nNOS inhibitor[74209-34-0]
    Nomega-Propyl-L-arginine hydrochlorideHighly selective inhibitor of nNOS[137361-05-8]
    ARL 17477 dihydrochlorideSelective nNOS inhibitor[180983-17-9]

    10/14 HMDB Compounds for NOS1 (see all 14)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dihydrobiopterin
    • (S-(R*,S*))-2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone
    • 2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone
    • 2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone
    • 7,8-Dihydro-L-biopterin
    • 7,8-Dihydrobiopterin
    • Dihydrobiopterin
    • L-erythro-1-(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-1,2-Propanediol
    • L-erythro-7,8-Dihydrobiopterin
    • L-erythro-Dihydrobiopterin
    • L-erythro-q-Dihydrobiopterin
    • Quinonoid dihydrobiopterin
    • BH2
    • 6,7-Dihydrobiopterin
    • Quinoid-dihydrobiopterin
    • (6R)-6-(L-erythro-1,2-Dihydroxypropyl)-7,8-dihydro-6H-pterin
    (see top 1)
    6779-87-916804678
    Tetrahydrobiopterin
    • (1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol
    • 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone
    • 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-Pteridinone
    • 5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone
    • 5,6,7,8-Tetrahydrobiopterin
    • 5,6,7,8-erythro-tetrahydrobiopterin
    • 5,6,7,8-tetra-H-biopterin
    • L-erythro-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinon
    • Tetrahydrobiopterin
    • tetra-H-biopterin
    • tetra-hydro-biopterin
    (see top 1)
    17528-72-216216381
    Calcium
    • Ca
    • Calcium element
    (see top 1)
    7440-70-2--
    Citrulline
    • (2S)-2-amino-5-(carbamoylamino)pentanoic acid
    • (S)-2-Amino-5-ureidopentanoate
    • (S)-2-Amino-5-ureidopentanoic acid
    • (S)-2-amino-5-(aminocarbonyl)aminopentanoic acid
    • 2-Amino-5-uredovalerate
    • 2-Amino-5-uredovaleric acid
    • 2-Amino-5-ureidovalerate
    • 2-Amino-5-ureidovaleric acid
    • A-amino-d-ureidovalerate
    • A-amino-d-ureidovaleric acid
    • Alpha-amino-delta-ureidovalerate
    • Alpha-amino-delta-ureidovaleric acid
    • Alpha-amino-gamma-ureidovalerate
    • Alpha-amino-gamma-ureidovaleric acid
    • Amino-ureidovalerate
    • Amino-ureidovaleric acid
    • CIR
    • CIT
    • Cytrulline
    • D-ureidonorvaline
    • DL-citrulline
    • Delta-ureidonorvaline
    • Gammaureidonorvaline
    • H-cit-oh
    • L(+)-2-Amino-5-ureidovalerate
    • L(+)-2-Amino-5-ureidovaleric acid
    • L(+)-citrulline
    • L-2-Amino-5-ureido-valerate
    • L-2-Amino-5-ureido-valeric acid
    • L-2-Amino-5-ureidovalerate
    • L-2-Amino-5-ureidovaleric acid
    • L-N5-carbamoyl-Ornithine
    • L-citrulline
    • L-cytrulline
    • N()-carbamylornithine
    • N(5)-(aminocarbonyl)-DL-Ornithine
    • N(delta)-carbamylornithine
    • N-carbamylornithine
    • N5-(Aminocarbonyl)-L-ornithine
    • N5-(Aminocarbonyl)ornithine
    • N5-(aminocarbonyl)-Ornithine
    • N5-Carbamoyl-L-ornithine
    • N5-carbamoylornithine
    • N5-carbamylornithine
    • N5-(aminocarbonyl)ornithine
    • ND-carbamylornithine
    • Ndelta-carbamy-ornithine
    • Ndelta-carbamylornithine
    • Ngamma-carbamylornithine
    • Sitrulline
    • Ureidonorvaline
    • Ureidovalerate
    • Ureidovaleric acid
    • (2S)-2-amino-5-(carbamoylamino)pentanoate
    • (S)-2-amino-5-(aminocarbonyl)aminopentanoate
    (see top 1)
    372-75-8--
    FAD
    • 1H-Purin-6-amine flavin dinucleotide
    • 1H-Purin-6-amine flavine dinucleotide
    • Adenine-flavin dinucleotide
    • Adenine-flavine dinucleotide
    • Adenine-riboflavin dinuceotide
    • Adenine-riboflavin dinucleotide
    • Adenine-riboflavine dinucleotide
    • FAD
    • Flamitajin B
    • Flanin F
    • Flavin adenine dinucleotide
    • Flavin-adenine dinucleotide
    • Flavine adenosine diphosphate
    • Flavine-adenine dinucleotide
    • Flavitan
    • Flaziren
    • Isoalloxazine-adenine dinucleotide
    • Riboflavin 5'-adenosine diphosphate
    • Riboflavin-adenine dinucleotide
    • Riboflavine-adenine dinucleotide
    • flavin adenine dinucleotide oxidized
    (see top 1)
    146-14-5--
    Flavin Mononucleotide
    • FMN
    • Flanin
    • Flavine mononucleotide
    • Flavol
    • Riboflavin
    • Riboflavin 5'-monophosphate
    • Riboflavin 5'-phosphate
    • Riboflavin Mononucleotide
    • Riboflavin monophosphate
    • Riboflavin phosphate
    • Riboflavin-5'-phosphate na
    • Riboflavin-5-phosphate
    • Riboflavine 5'-monophosphate
    • Riboflavine 5'-phosphate
    • Riboflavine dihydrogen phosphate
    • Riboflavine monophosphate
    • Riboflavine phosphate
    • Riboflavine-5'-phosphate
    • Vitamin B2 phosphate
    (see top 1)
    146-17-8--
    Heme
    • (protoporphyrinato)iron
    • Ferroheme
    • Ferroheme b
    • Ferroprotoheme
    • Ferroprotoporphyrin
    • Ferroprotoporphyrin IX
    • Ferrous protoheme
    • Ferrous protoheme IX
    • Haem
    • Hem
    • Heme
    • Iron protoporphyrin
    • Iron protoporphyrin IX
    • Iron(II) protoporphyrin IX
    • Protoferroheme
    • Protohaem
    • Protoheme
    • Protoheme IX
    • Reduced hematin
    (see top 1)
    14875-96-8--
    L-Arginine
    • (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate
    • (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid
    • 2-amino-5-guanidinovalerate
    • 2-amino-5-guanidinovaleric acid
    • 5-[(aminoiminomethyl)amino]-L-Norvaline
    • Arginine
    • L-(+)-Arginine
    • L-a-Amino-d-guanidinovalerate
    • L-a-Amino-d-guanidinovaleric acid
    • N5-(aminoiminomethyl)-L-Ornithine
    • L-alpha-Amino-delta-guanidinovalerate
    • L-alpha-Amino-delta-guanidinovaleric acid
    • (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoic acid
    • (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoate
    (see top 1)
    74-79-3--
    N-(o)-Hydroxyarginine
    • N-(G)-Hydroxyarginine
    • N-(omega)-Hydroxyarginine
    (see top 1)
    ----
    NADP
    • Adenine-nicotinamide dinucleotide phosphate
    • Codehydrase II
    • Codehydrogenase II
    • Coenzyme II
    • Cozymase II
    • NAD phosphate
    • NADP
    • NADP+
    • Nicotinamide adenine dinucleotide phosphate
    • Nicotinamide-adenine dinucleotide phosphate
    • TPN
    • Triphosphopyridine nucleotide
    • b-NADP
    • b-Nicotinamide adenine dinucleotide phosphate
    • b-TPN
    • beta-NADP
    • beta-Nicotinamide adenine dinucleotide phosphate
    • beta-TPN
    (see top 1)
    53-59-8--

    10/26 DrugBank Compounds for NOS1 (see all 26)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--10681601 10502685 10962148 10945985 10799481
    (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin-- --target--17139284 17016423 10592235
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--17139284 17016423 10592235
    3-Bromo-7-Nitroindazole-- --target--17139284 17016423 10592235
    5-N-Allyl-Arginine-- --target--17139284 17016423 10592235
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423 10592235
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423 10592235
    Heme-- --target--17139284 17016423 10592235
    L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide-- --target--17139284 17016423 10592235
    L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide-- --target--17139284 17016423 10592235

    2 IUPHAR Ligands for NOS1 (Neuronal NOS)    About this table 
    LigandTypeActionAffinityPubmed IDs
    3-bromo-7NI
    InhibitorInhibition6.1 - 6.57544863
    7NI
    InhibitorInhibition5.37693279

    10/127 Novoseek inferred chemical compound relationships for NOS1 gene (see all 127)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nitric oxide 94.2 3522 18580182 (7), 16581191 (7), 17320763 (6), 7524095 (6) (see all 99)
    tetrahydrobiopterin 92.1 193 16216381 (6), 7691806 (5), 9858648 (4), 7514193 (2) (see all 99)
    citrulline 87.1 144 12586539 (4), 14725962 (3), 17110176 (3), 8962079 (2) (see all 91)
    7-nitroindazole 85.1 167 7542758 (3), 11448483 (3), 12322787 (3), 15138761 (2) (see all 70)
    arginine 84.3 472 7519607 (9), 14602725 (5), 15007014 (5), 8955074 (4) (see all 99)
    n(g)-hydroxy-l-arginine 81.7 27 9398165 (4), 19128180 (3), 11481035 (2), 9735327 (1) (see all 12)
    nadph 81.2 265 10847600 (6), 7528212 (5), 12429187 (4), 8690302 (4) (see all 99)
    dihydrobiopterin 78.6 14 8626754 (3), 16804678 (1), 15476407 (1), 16118486 (1) (see all 6)
    peroxynitrite 75.9 47 8839053 (4), 11085318 (3), 12208472 (2), 9398256 (2) (see all 28)
    n-omega-propyl-l-arginine 75 21 15160393 (2), 16423462 (1), 17572695 (1), 19019012 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about NOS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOS1 gene (4 alternative transcripts): 
    NM_000620.4  NM_001204213.1  NM_001204214.1  NM_001204218.1  

    Unigene Clusters for NOS1:

    Nitric oxide synthase 1 (neuronal)
    Hs.654410  [show with all ESTs], Hs.684465 , Hs.684466 , Hs.684467 , Hs.735734  [show with all ESTs]
    Unigene Representative Sequences: NM_001204218, AF446137, AF446133, AF446132, DA522461
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317775(uc021ren.1 uc021reo.1 uc001twn.2 uc001twm.2)
    ENST00000338101 ENST00000549189 ENST00000477584 ENST00000344089
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOS1
    8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate NOS1 (see all 74):
    hsa-miR-4254 hsa-miR-146a hsa-miR-15a hsa-miR-938 hsa-miR-371-5p hsa-miR-502-3p hsa-miR-149 hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidNOS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NOS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOS1
    Clone
    Products:
         
    OriGene clones in human, mouse for NOS1 (see all 7)
    OriGene ORF clones in mouse, rat for NOS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): NOS1 (NM_000620)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOS1
    Sirion Biotech Customized lentivirus for stable overexpression of NOS1 
                         Customized lentivirus expression plasmids for stable overexpression of NOS1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NOS1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOS1

    Additional mRNA sequence: AF446131.1 

    7 DOTS entries:

    DT.209591  DT.430999  DT.40118528  DT.91668000  DT.121200078  DT.87046327  DT.91658756 

    24/49 AceView cDNA sequences (see all 49):

    U17327 AI914145 BX105805 NM_000620 BE744153 BX115063 AJ004918 BC010126 
    AF446131 AI299150 AI793292 AA935529 AA923118 BF447723 BF433556 BE669690 
    AI302351 BM549127 BF095488 BI115269 CD609198 Z28891 AI791677 U31466 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOS1 expression in normal human tissues (normalized intensities)      NOS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGCTTCT
    NOS1 Expression
    About this image


    NOS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 28 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             Ureter
             visceral organ   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Midgut
     
     Skeletal Muscle (Muscoskeletal System)
             gastrocnemius   

    See NOS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOS1

    SOURCE GeneReport for Unigene clusters: Hs.654410 Hs.684465 Hs.684466 Hs.684467 Hs.735734

    UniProtKB/Swiss-Prot: NOS1_HUMAN, P29475
    Tissue specificity: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis,
    lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3
    is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in
    the brain, but not in the heart and adrenal gland

        SABiosciences Expression via Pathway-Focused PCR Arrays including NOS1: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NOS1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOS1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOS1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NOS1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nos11 , 5 nitric oxide synthase 1, neuronal1, 5 87.05(n)1
    94.05(a)1
      5 (57.29 cM)5
    181251  NM_008712.21  NP_032738.11 
     1177810325 
    chicken
    (Gallus gallus)
    Aves NOS11 nitric oxide synthase 1 (neuronal) 79.98(n)
    84.32(a)
      427721  XM_425296.2  XP_425296.2 
    lizard
    (Anolis carolinensis)
    Reptilia NOS16
    nitric oxide synthase 1 (neuronal)
    81(a)
    1 ↔ 1
    LGb(2413952-2463375)
    African clawed frog
    (Xenopus laevis)
    Amphibia nos1-A2 neuronal nitric oxide synthase 1 76.45(n)    AF053935.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nos12 nitric oxide synthase 1 (neuronal) 74.9(n)   60658  AY211528.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nos1 , 3 imaginal disc development calmodulin
    binding3
    Nitric oxide synthase1
    49(a)3
    53.9(n)1
    48.33(a)1
      2 32B13
    344951  NM_078817.31  NP_523541.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NCP16
    NADP-cytochrome P450 reductase; involved in ergost...
    23(a)
    1 → many
    VIII(190543-192618)


    ENSEMBL Gene Tree for NOS1 (if available)
    TreeFam Gene Tree for NOS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOS1 gene
    NOS32  POR2  NOS22  MTRR2  
    2 SIMAP similar genes for NOS1 using alignment to 5 protein entries:     NOS1_HUMAN (see all proteins):
    NOS3    NOS2

    NOS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3617 SNPs in NOS1 are shown (see all 3617)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495514001,2
    --114654634(+) TTCCCC/TTCCCC 4 -- ds50010--------
    rs779348951,2
    C,F--114654681(+) TCTTTT/CCCTCT 4 -- ds50011Minor allele frequency- C:0.16EA 120
    rs732060861,2
    C,F--114654699(+) CTTTCC/TCTCCT 4 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1878691161,2
    --114654871(+) CCTCCC/TCTCTC 4 -- ds50010--------
    rs560557391,2
    C--114655039(+) TCTGGA/GGCACC 4 -- ds50010--------
    rs714446101,2
    C--114655364(+) ACAGC-/GT/GTG
    TGTGTGTGT
    GTGTG
    8 -- ut31 cds11NA 2
    rs668864451,2
    C--114655365(+) CAGCG-/GT/GTGTG
    TGTGTGTGTGT
    TGTGT
    8 -- ut310--------
    rs587149991,2
    C--114655395(+) GTGTG-/TGT/TGTGT/TGTGTGTGT
    GTGT
    /TGTGTGTGTGTGTGTG
    GTGAG
    16 -- cds1 ut310--------
    rs1918675061,2
    --114655723(+) ACAGGG/TTCTCA 4 -- ut310--------
    rs73081501,2
    C,F,A--114655764(+) CATCTC/TGGCTC 4 -- ut312Minor allele frequency- T:0.50WA CSA 4

    HapMap Linkage Disequilibrium report for NOS1 (117645947 - 117889975 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NOS1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746436CNV Deletion23290073
    esv2746435CNV Deletion23290073
    nsv901CNV Insertion18451855
    nsv509478CNV Insertion20534489
    nsv832526CNV Loss17160897
    nsv53465CNV Loss16902084
    nsv510592CNV Loss20534489


    Human Gene Mutation Database (HGMD): NOS1

    Locus Specific Mutation Databases (LSDB): NOS1
    1 SABiosciences Cancer Mutation PCR Assay for NOS1:
    Cosmic IdAA Change
    110337p.S771L
    SeqTarget long-range PCR primers for resequencing NOS1
    DNA2.0 Custom Variant and Variant Library Synthesis for NOS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 163731    OMIM disorders: --

    20/158 diseases for NOS1 (see all 158):    About MalaCards
    pyloric stenosis    hypertrophic pyloric stenosis    factitious disorder    achalasia
    intestinal perforation    sepiapterin reductase deficiency    cerebral hypoxia    psychotic disorder
    mood disorder    impotence    gastroparesis    schizoaffective disorder
    childhood-onset schizophrenia    neuronitis    scoliosis    gastroschisis
    brain injury    brain ischemia    hyperphenylalaninemia    tetrahydrobiopterin deficiency

    1 disease from the University of Copenhagen DISEASES database for NOS1:
    Vascular disease

    NOS1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/92 Novoseek inferred disease relationships for NOS1 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyloric stenosis 59 21 11283889 (3), 14757827 (2), 9354728 (1), 15361336 (1) (see all 14)
    diabetic gastroparesis 54 6 12768383 (1), 17161551 (1), 17160518 (1), 20185690 (1) (see all 5)
    muscular dystrophy duchenne 51.2 20 17313973 (2), 11745948 (2), 9536265 (1), 9398448 (1) (see all 16)
    pyloric stenosis, infantile 50.5 4 8571963 (2)
    neurodegenerative diseases 49.3 23 7523410 (2), 19268602 (1), 20337441 (1), 9847056 (1) (see all 13)
    erectile dysfunction 47.9 4 9284206 (1), 9631946 (1), 7588327 (1), 8562693 (1)
    schizophrenia 45.5 85 19513863 (6), 12140778 (4), 19200422 (4), 18544180 (3) (see all 46)
    brain ischemia 43.5 3 16141535 (1), 10320673 (1)
    schizoaffective disorder 42.7 12 9988837 (1), 17665305 (1), 8483645 (1), 17267179 (1) (see all 11)
    neurodegeneration 41.9 15 15579064 (1), 16095570 (1), 16179512 (1), 18805011 (1) (see all 11)

    Genetic Association Database (GAD): NOS1
    Human Genome Epidemiology (HuGE) Navigator: NOS1 (103 documents)

    Export disorders for NOS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOS1 gene, integrated from 9 sources (see all 1616):
    (articles sorted by number of sources associating them with NOS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic association analysis of functional polymorphi sms in neuronal nitric oxide synthase 1 gene (NOS1) and mood disorders and fluv oxamine response in major depressive disorder in the Japanese population. (PubMed id 20016223)1, 4, 9 Okumura T....Iwata N. (2010)
    2. Nasal nitric oxide levels in cystic fibrosis patients are associated with a neuronal NO synthase (NOS1) gene polymorphism. (PubMed id 11890749)1, 4, 9 Grasemann H....Ratjen F. (2002)
    3. Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome. (PubMed id 18058820)1, 4, 9 Winkelmann J....Muller-Myhsok B. (2008)
    4. Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (PubMed id 14757827)1, 4, 9 Saur D....Allescher H.-D. (2004)
    5. Expression of two types of nitric oxide synthase mRNA in human neuroblastoma cell lines. (PubMed id 7515942)1, 2, 9 Fujisawa H....Esumi H. (1994)
    6. Association between achalasia and nitric oxide synthase gene polymorphisms. (PubMed id 16848803)1, 4, 9 Mearin F....Lanas A. (2006)
    7. Effects of sex and of gene variants in constitutive nitric oxide synthases on exhaled nitric oxide. (PubMed id 12531780)1, 4, 9 Grasemann H....Ratjen F. (2003)
    8. Allelic association of the neuronal nitric oxide synthase (NOS1) gene with schizophrenia. (PubMed id 12140778)1, 4, 9 Shinkai T....Nakamura J. (2002)
    9. Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects. (PubMed id 19805695)1, 4, 9 Donohoe G....Corvin A. (2009)
    10. Environmental exposures, nitric oxide synthase genes, and exhaled nitric oxide in asthmatic children. (PubMed id 19603529)1, 4, 9 Spanier A.J....Lanphear B.P. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4842 HGNC: 7872 AceView: NOS1 Ensembl:ENSG00000089250 euGenes: HUgn4842
    ECgene: NOS1 Kegg: 4842 H-InvDB: NOS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOS1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nos1/
    Wikipedia http://en.wikipedia.org/wiki/Nitric_oxide_synthase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOS1 gene:
    Search GeneIP for patents involving NOS1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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