Aliases for NOS1 Gene
Aliases for NOS1 Gene
External Ids for NOS1 Gene
- HGNC: 7872
- Entrez Gene: 4842
- Ensembl: ENSG00000089250
- OMIM: 163731
- UniProtKB: P29475
Previous HGNC Symbols for NOS1 Gene
- NOS
Previous GeneCards Identifiers for NOS1 Gene
- GC12M116666
- GC12M117431
- GC12M116060
- GC12M116111
- GC12M117636
- GC12M114660
Summaries for NOS1 Gene
-
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
GeneCards Summary for NOS1 Gene
NOS1 (Nitric Oxide Synthase 1) is a Protein Coding gene. Diseases associated with NOS1 include Achalasia, Familial Esophageal and Pyloric Stenosis, Infantile Hypertrophic, 1. Among its related pathways are Cardiac conduction and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and iron ion binding. An important paralog of this gene is NOS3.
UniProtKB/Swiss-Prot for NOS1 Gene
-
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
-
Neuronal nitric oxide synthase (nNOS), with inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS), catalyzes nitric oxide and L-citrulline generation from L-arginine and molecular oxygen. nNOS is activated at calcium concentrations over 100 nM.
Additional gene information for NOS1 Gene
- Monarch Initiative
- Search for NOS1 at DataMed
- Search for NOS1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOS1 Gene
Genomics for NOS1 Gene
GeneHancer (GH) Regulatory Elements for NOS1 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12I117362 | Promoter | 0.7 | EPDnew | 558.5 | +90.4 | 90449 | 0.1 | SUZ12 EZH2 | NOS1 GC12M117361 GC12M117362 GC12M117408 GC12M117409 | |
GH12I117485 | Enhancer | 1 | Ensembl ENCODE | 11.6 | -34.7 | -34721 | 2.2 | SIN3A GLIS2 FOS EGR2 SMARCA5 REST SP1 ZNF217 PRDM6 MTA1 | ENSG00000255686 NOS1 GC12M117454 LOC105370012 GC12M117481 KSR2 | |
GH12I117407 | Enhancer | 0.5 | ENCODE | 20.6 | +43.9 | 43911 | 1.2 | ZFHX2 HNF4A ZFX RAD21 GABPA EGR2 | GC12M117408 GC12M117409 NOS1 ENSG00000255686 GC12M117361 GC12M117362 | |
GH12I117434 | Enhancer | 0.6 | FANTOM5 | 14.2 | +17.9 | 17855 | 0.5 | SREBF1 HDGF ZFHX2 ZNF680 ZNF512B YBX1 EGR2 | NOS1 GC12M117439 GC12M117440 GC12M117408 GC12M117409 | |
GH12I117501 | Enhancer | 0.7 | ENCODE | 11.3 | -49.5 | -49531 | 0.1 | KLF1 FOXA2 RXRA HLF CEBPB MAX CEBPG REST RAD21 YY1 | ENSG00000255686 NOS1 LOC105370012 GC12M117454 GC12M117481 KSR2 |
Regulatory Element Products
Genomic Locations for NOS1 Gene
- chr12:117,208,142-117,452,170
- (GRCh38/hg38)
- Size:
- 244,029 bases
- Orientation:
- Minus strand
- chr12:117,645,947-117,889,975
- (GRCh37/hg19)
Genomic View for NOS1 Gene
- Cytogenetic band:
-
- 12q24.22 by Ensembl
- 12q24.22 by Entrez Gene
- 12q24.22 by HGNC


RefSeq DNA sequence for NOS1 Gene
Proteins for NOS1 Gene
-
Protein details for NOS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29475-NOS1_HUMAN
- Recommended name:
- Nitric oxide synthase, brain
- Protein Accession:
- P29475
- E9PH30
- O75713
Protein attributes for NOS1 Gene
- Size:
- 1434 amino acids
- Molecular mass:
- 160970 Da
- Cofactor:
- Name=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; Xref=ChEBI:CHEBI:59560;
- Cofactor:
- Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cofactor:
- Name=FMN; Xref=ChEBI:CHEBI:58210;
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
-
- Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with HTR4. Interacts with VAC14 (By similarity). Interacts with SLC6A4 (By similarity). Interacts (via N-terminal domain) with DLG4 (via N-terminal tandem pair of PDZ domains) (By similarity).
Three dimensional structures from OCA and Proteopedia for NOS1 Gene
Protein Expression for NOS1 Gene
Selected DME Specific Peptides for NOS1 Gene
- P29475:
-
- PPELVLEVP
- VLEEFPS
- SRQNLQSP
- RGGCPADW
- GNLRSAIT
- MAKRVKATILY
- GWYMGTE
- QYYSSIKR
- LQVFDAR
- ASETHVVLILRGPEGFTT
- LPRNPQVPCILVGPGT
- GQEEAFR
- NLQSPKSSR
- DGKHDFR
- GVCSSWLNR
- VVLTDTLHLKSTLETGCTE
- VEINIAVL
- STFGNGDPPENG
- LLQPRYYS
- VVTSTFGNGD
- LQYQPGDH
- RAIGFKKLA
- LETTFTGDGTPKTIRVTQPLG
- LDITTPP
- VFGLGSR
- PLVDLSYDSALEV
- LPAVSNMLLEIGGLEF
- QLIRYAGY
- ITIFPQR
- ATETGKS
- PCPMVLVFGCRQSKIDHIYREE
- VTIVDHH
- CALMEMRHPNS
- TPVFHQEM
- YPHFCAF
- RFDVLPLLLQA
- APFRSFWQQR
- VCGDVTMA
Post-translational modifications for NOS1 Gene
- Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro).
Other Protein References for NOS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NOS1 (nNOS)
- Cell Signaling Technology (CST) Antibodies for NOS1 (nNOS)
- Novus Biologicals Antibodies for NOS1
-
Abcam antibodies for NOS1
-
Cloud-Clone Corp. Antibodies for NOS1
- Invitrogen Antibodies for NOS1
- antibodies-online: Search results for 310 available NOS1 Antibodies ranked by validation data
- Compare Top NOS1 Antibodies
-
Recommended
- 1 IHC (fro) Antibody (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 7 IF Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 106 WB Antibodies (anti-mouse)
- 1 IHC (fro) Antibody (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 3 ICC Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 7 IF Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 123 WB Antibodies (anti-rat)
- 2 FACS Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 10 IF Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 174 WB Antibodies (anti-human)
- GeneTex NOS1 antibody for NOS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for NOS1
Protein Products
-
OriGene Purified Proteins for NOS1
- Search Origene for MassSpec and Protein Over-expression Lysates for NOS1
- Origene Custom Protein Services for NOS1
-
Cloud-Clone Corp. Proteins for NOS1
- Search GeneTex for Proteins for NOS1
-
Abcam proteins for NOS1
Assay Products
-
Abcam assays for NOS1
Domains & Families for NOS1 Gene
Gene Families for NOS1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for NOS1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NOS1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P29475UniProtKB/Swiss-Prot:
NOS1_HUMAN :- The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By similarity).
- Belongs to the NOS family.
- Domain:
-
- The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By similarity).
- Family:
-
- Belongs to the NOS family.
Function for NOS1 Gene
Molecular function for NOS1 Gene
- GENATLAS Biochemistry:
- nitric oxide synthase 1,constitutive by expressed,neuronal,putative susceptibility gene for infantile pyloric stenosis,widely expressed with a high expression in skeletal muscle
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent the dimerization of the protein. Inhibited by NOSIP.
- UniProtKB/Swiss-Prot Function:
- Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
Enzyme Numbers (IUBMB) for NOS1 Gene
Phenotypes From GWAS Catalog for NOS1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003958 | NADPH-hemoprotein reductase activity | IBA | -- |
GO:0004517 | nitric-oxide synthase activity | IEA,TAS | -- |
GO:0005506 | iron ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 11149895 |
GO:0005516 | calmodulin binding | IEA | -- |
Phenotypes for NOS1 Gene
- MGI mutant phenotypes for NOS1:
-
inferred from 6 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for NOS1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NOS1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NOS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NOS1 gene
- Search ViGene Biosciences for NOS1
CRISPR Products
-
OriGene CRISPR knockouts for NOS1
- genomics-online: gRNA clones - Search results for 81 available NOS1 gene related products
- Overview of 81 available NOS1 gene related products
- Applied Biological Materials CRISPR for NOS1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NOS1
- GenScript: Design CRISPR guide RNA sequences for NOS1
miRNA for NOS1 Gene
- miRTarBase miRNAs that target NOS1
-
- hsa-mir-146a-5p (MIRT735124)
- hsa-mir-1273f (MIRT783312)
- hsa-mir-143-3p (MIRT783811)
- hsa-mir-147a (MIRT783856)
- hsa-mir-3622a-5p (MIRT784976)
- hsa-mir-3911 (MIRT785428)
- hsa-mir-4269 (MIRT785560)
- hsa-mir-4708-5p (MIRT786482)
- hsa-mir-4710 (MIRT786499)
- hsa-mir-4770 (MIRT786696)
- hsa-mir-4792 (MIRT786788)
- hsa-mir-574-5p (MIRT787873)
- hsa-mir-6088 (MIRT788038)
- hsa-mir-644a (MIRT788184)
- hsa-mir-6715b-5p (MIRT788450)
- hsa-mir-6768-5p (MIRT788631)
- hsa-mir-6867-5p (MIRT789213)
- hsa-mir-7855-5p (MIRT789601)
- hsa-mir-8485 (MIRT789865)
miRNA Products
- Search ViGene Biosciences for NOS1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for NOS1
- Browse OriGene Inhibitory RNA Products For NOS1
- genomics-online: shRNA clones - Search results for 81 available NOS1 gene related products
- Overview of 81 available NOS1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NOS1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NOS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NOS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NOS1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NOS1
-
ViGene Biosciences adenoviral particle packaged cDNA for NOS1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NOS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NOS1 gene
No data available for Transcription Factor Targets and HOMER Transcription for NOS1 Gene
Localization for NOS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NOS1 Gene
- Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity). {ECO:0000250}.
- Plasma membrane (3)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001917 | photoreceptor inner segment | ISS | 17027776 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | TAS | 17892502 |
GO:0005739 | mitochondrion | IEA,ISS | -- |
GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for NOS1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cardiac conduction |
.39
|
|
2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
3 | Amyotrophic lateral sclerosis (ALS) | ||
4 | Arginine biosynthesis | ||
5 | Innate Immune System |
.61
|
Pathways by source for NOS1 Gene
2 Cell Signaling Technology pathways for NOS1 Gene
10 BioSystems pathways for NOS1 Gene
9 Reactome pathways for NOS1 Gene
3 PharmGKB pathways for NOS1 Gene
12 KEGG pathways for NOS1 Gene
3 GeneGo (Thomson Reuters) pathways for NOS1 Gene
Interacting Proteins for NOS1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001666 | response to hypoxia | IEP | 16276418 |
GO:0002028 | regulation of sodium ion transport | IEA,ISS | -- |
GO:0006527 | arginine catabolic process | IC | 7545544 |
GO:0006809 | nitric oxide biosynthetic process | IEA,ISS | 7545544 |
GO:0006941 | striated muscle contraction | IEA,ISS | -- |
No data available for SIGNOR curated interactions for NOS1 Gene
Drugs & Compounds for NOS1 Gene
(128) Drugs for NOS1 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Citrulline | Approved, Investigational | Nutra | Full agonist, Agonist, Target | 0 | ||
FAD | Approved | Pharma | Target | 0 | ||
Nitric Oxide | Approved | Pharma | 643 | |||
Oxygen | Approved, Vet_approved | Pharma | 0 | |||
Doxorubicin | Approved, Investigational | Pharma | Enzyme, substrate | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 1828 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
nadph |
|
53-57-6 | ||||
Hydrogen Ion |
|
|
||||
N-(o)-Hydroxyarginine |
|
|
||||
NADP |
|
53-59-8 |
|
|||
Nomega-Propyl-L-arginine hydrochloride |
|
137361-05-8 |
|
|
(3) Tocris Compounds for NOS1 Gene
Compound | Action | Cas Number |
---|---|---|
3-Bromo-7-nitroindazole | Selective nNOS inhibitor | 74209-34-0 |
ARL 17477 dihydrochloride | Selective nNOS inhibitor | 866914-87-6 |
Nomega-Propyl-L-arginine hydrochloride | Highly selective inhibitor of nNOS | 137361-05-8 |
(23) ApexBio Compounds for NOS1 Gene
Compound | Action | Cas Number |
---|---|---|
(S)-Methylisothiourea sulfate | 867-44-7 | |
1400W dihydrochloride | INOS inhibitor,potent and highly selective | 214358-33-5 |
2,4-Diamino-6-hydroxypyrimidine | 1956-06-4 | |
2-Iminopiperidine hydrochloride | 16011-96-4 | |
3-Bromo-7-nitroindazole | 74209-34-0 | |
7-NINA | 161467-34-1 | |
7-Nitroindazole | 2942-42-9 | |
Aminoguanidine hydrochloride | 1937-19-5 | |
AMT hydrochloride | 21463-31-0 | |
AR-C 102222 | 253771-21-0 | |
ARL 17477 dihydrochloride | Selective nNOS inhibitor | 866914-87-6 |
BYK 191023 dihydrochloride | INOS inhibitor,potent and selective | 1216722-25-6 |
Carboxy-PTIO, potassium salt | 148819-94-7 | |
DMPO | 3317-61-1 | |
EIT hydrobromide | 1071-37-0 | |
L-Canavanine sulfate | 2219-31-0 | |
L-NIL hydrochloride | 150403-89-7 | |
L-NMMA acetate | 53308-83-1 | |
Nω-Propyl-L-arginine hydrochloride | 137361-05-8 | |
ODQ | 41443-28-1 | |
Saikosaponin A | COX-2 and iNOS inhibitor | 20736-09-8 |
S-Isopropylisothiourea hydrobromide | 4269-97-0 | |
TRIM | 25371-96-4 |
Transcripts for NOS1 Gene
mRNA/cDNA for NOS1 Gene
- (8) REFSEQ mRNAs :
- (49) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for NOS1
- genomics-online: gRNA clones - Search results for 81 available NOS1 gene related products
- Overview of 81 available NOS1 gene related products
- Applied Biological Materials CRISPR for NOS1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NOS1
- GenScript: Design CRISPR guide RNA sequences for NOS1
miRNA Products
- Search ViGene Biosciences for NOS1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for NOS1
- Browse OriGene Inhibitory RNA Products For NOS1
- genomics-online: shRNA clones - Search results for 81 available NOS1 gene related products
- Overview of 81 available NOS1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NOS1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NOS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NOS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NOS1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NOS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Adult Endothelial Cells Blood Brain Barrier
- Cerebellum
- Midbrain tegmentum
-
Endothelium (Cardiovascular System)
- Umbilical vein endothelial cells Umbilical Veins
- Adult Endothelial Cells Blood Brain Barrier
- Inner Cell Mass (Early Embryonic Tissues)
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
-
Umbilical Cord (Extraembryonic Tissues)
- Umbilical vein endothelial cells Umbilical Veins
- Gut Tube (Gastrointestinal Tract)
- Lower Urinary Tract (Urinary System)
mRNA differential expression in normal tissues according to GTEx for NOS1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOS1 Gene
NURSA nuclear receptor signaling pathways regulating expression of NOS1 Gene:
NOS1SOURCE GeneReport for Unigene cluster for NOS1 Gene:
Hs.654410mRNA Expression by UniProt/SwissProt for NOS1 Gene:
P29475-NOS1_HUMANEvidence on tissue expression from TISSUES for NOS1 Gene
- Nervous system(4.8)
- Muscle(4.7)
- Eye(4.4)
- Blood(2.5)
- Lung(2.4)
- Heart(2.3)
- Intestine(2.3)
- Kidney(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NOS1 Gene
- ectoderm
- endoderm
- mesoderm
- digestive
- immune
- nervous
- skeleton
- eye
- head
- jaw
- lacrimal apparatus
- mandible
- maxilla
- mouth
- neck
- salivary gland
- skull
- tongue
- chest wall
- clavicle
- esophagus
- rib
- rib cage
- scapula
- sternum
- pelvis
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for NOS1
- genomics-online: primer clones - Search results for 81 available NOS1 gene related products
- Overview of 81 available NOS1 gene related products
No data available for Protein tissue co-expression partners for NOS1 Gene
Orthologs for NOS1 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NOS1 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
-- 34 |
|
OneToMany | |||
oppossum (Monodelphis domestica) |
Mammalia | NOS1 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | NOS1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | NOS1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Nos1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Nos1 33 16 34 |
|
||
chicken (Gallus gallus) |
Aves | NOS1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | NOS1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | nos1 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | nos1-A 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | nos1 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008255 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Nos 35 33 34 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NCP1 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5751 34 |
|
OneToMany | |
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.12824 33 |
|
- Species where no ortholog for NOS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NOS1 Gene
(2) SIMAP similar genes for NOS1 Gene using alignment to 5 proteins:
Variants for NOS1 Gene
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs41279104 | uncertain-significance, Pyloric stenosis, infantile hypertrophic 1 | 117,439,680(-) | C/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant | |
rs1060499530 | uncertain-significance, not provided | 117,227,441(-) | G/C | coding_sequence_variant, stop_gained | |
rs1000006523 | -- | 117,313,158(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
rs1000013967 | -- | 117,292,081(-) | T/C | intron_variant | |
rs1000027954 | -- | 117,393,126(-) | G/C | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2903n54 | CNV | loss | 21841781 |
esv2746435 | CNV | deletion | 23290073 |
esv2746436 | CNV | deletion | 23290073 |
esv3581916 | CNV | gain | 25503493 |
esv3630863 | CNV | gain | 21293372 |
nsv1051681 | CNV | gain | 25217958 |
nsv1070131 | CNV | deletion | 25765185 |
nsv1113524 | CNV | deletion | 24896259 |
nsv1142817 | CNV | tandem duplication | 24896259 |
nsv509478 | CNV | insertion | 20534489 |
nsv510592 | CNV | deletion | 20534489 |
nsv53465 | CNV | deletion | 16902084 |
nsv560385 | CNV | loss | 21841781 |
nsv832526 | CNV | loss | 17160897 |
nsv901 | CNV | insertion | 18451855 |
Additional Variant Information for NOS1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOS1 Gene
Disorders for NOS1 Gene

(30) MalaCards diseases for NOS1 Gene - From: HGMD, OMIM, Orphanet, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
achalasia, familial esophageal |
|
|
pyloric stenosis, infantile hypertrophic, 1 |
|
|
impotence |
|
|
pyloric stenosis |
|
|
hypertrophic pyloric stenosis |
|
|
Additional Disease Information for NOS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NOS1 Gene
Publications for NOS1 Gene
- Genetic association analysis of functional polymorphisms in neuronal nitric oxide synthase 1 gene (NOS1) and mood disorders and fluvoxamine response in major depressive disorder in the Japanese population. (PMID: 20016223) Okumura T … Iwata N (Neuropsychobiology 2010) 3 22 44 58
- Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome. (PMID: 18058820) Winkelmann J … Müller-Myhsok B (Movement disorders : official journal of the Movement Disorder Society 2008) 3 22 44 58
- Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis. (PMID: 14760158) Texereau J … Dinh-Xuan AT (Thorax 2004) 3 22 44 58
- Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. (PMID: 14757827) Saur D … Allescher HD (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 22 44 58
- Association analysis for neuronal nitric oxide synthase gene polymorphism with major depression and fluoxetine response. (PMID: 12759556) Yu YW … Tsai SJ (Neuropsychobiology 2003) 3 22 44 58
Products for NOS1 Gene
- R&D Systems Antibodies for NOS1 (nNOS)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for NOS1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NOS1
- Search Origene for MassSpec and Protein Over-expression Lysates for NOS1
- Origene Custom Protein Services for NOS1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NOS1
- Browse OriGene Inhibitory RNA Products For NOS1
- OriGene qPCR primer pairs for NOS1
- OriGene CRISPR knockouts for NOS1
- OriGene ORF clones in human for NOS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NOS1
- GenScript: Next-day shipping of latest version cDNA ORF clones for NOS1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for NOS1
- GenScript Custom Assay Services for NOS1
- GenScript Custom overexpressing Cell Line Services for NOS1
- GenScript: Design CRISPR guide RNA sequences for NOS1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NOS1
- Cell Signaling Technology (CST) Antibodies for NOS1 (nNOS)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for NOS1
- Novus Biologicals lysates and proteins for NOS1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for NOS1
- Abcam proteins for NOS1
- Abcam assays for NOS1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for NOS1
- Cloud-Clone Corp. Proteins for NOS1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for NOS1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for NOS1
- Cyagen custom Knockout/knockin (KOKI) mouse models for NOS1
- VectorBuilder custom plasmid, inducible vectors for NOS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NOS1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 310 available NOS1 Antibodies ranked by validation data
- Compare Top NOS1 Antibodies
- Recommended
- 174 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 10 IF Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 123 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 7 IF Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 3 ICC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (fro) Antibody (anti-rat)
- 106 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 7 IF Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (fro) Antibody (anti-mouse)
- antibodies-online: Search results for 52 available NOS1 Elisa Kits ranked by validation data
- Compare Top NOS1 Elisa Kits
- antibodies-online: Search results for 21 available NOS1 Proteins ranked by validation data
- Compare Top NOS1 Proteins
- GeneTex NOS1 antibody for NOS1
- Search GeneTex for Proteins for NOS1
- ViGene Biosciences adenoviral particle packaged cDNA for NOS1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NOS1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NOS1 gene
- Search ViGene Biosciences for NOS1
- Santa Cruz Biotechnology (SCBT) Antibodies for NOS1
- Search Santa Cruz Biotechnology (SCBT) for NOS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NOS1
- Horizon Cell Lines for NOS1
- genomics-online: cdna clones - Search results for 81 available NOS1 gene related products
- Overview of 81 available NOS1 gene related products
- orf clones - Search results for 81 available NOS1 gene related products
- Overview of 81 available NOS1 gene related products
- genomics-online: gRNA clones - Search results for 81 available NOS1 gene related products
- Overview of 81 available NOS1 gene related products
- genomics-online: primer clones - Search results for 81 available NOS1 gene related products
- Overview of 81 available NOS1 gene related products
- genomics-online: shRNA clones - Search results for 81 available NOS1 gene related products
- Overview of 81 available NOS1 gene related products
Sources for NOS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew