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Aliases for NOP9 Gene

Aliases for NOP9 Gene

  • NOP9 Nucleolar Protein 2 3 5
  • C14orf21 3 4
  • Pumilio Domain-Containing Protein C14orf21 3
  • NOP9 Nucleolar Protein Homolog (Yeast) 2
  • Chromosome 14 Open Reading Frame 21 2
  • NOP9 Nucleolar Protein Homolog 3
  • Nucleolar Protein 9 3
  • KIAA2021 4

External Ids for NOP9 Gene

Previous HGNC Symbols for NOP9 Gene

  • C14orf21

Previous GeneCards Identifiers for NOP9 Gene

  • GC14P024770

Summaries for NOP9 Gene

GeneCards Summary for NOP9 Gene

NOP9 (NOP9 Nucleolar Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding.

Additional gene information for NOP9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP9 Gene

Genomics for NOP9 Gene

Regulatory Elements for NOP9 Gene

Enhancers for NOP9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H024270 1.5 FANTOM5 ENCODE 21.1 -27.0 -27029 5.4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 IPO4 TSSK4 RNF31 HOMEZ KHNYN NOP9 NGDN DHRS1 TINF2 LTB4R
GH14H023319 1.2 ENCODE 20 -978.1 -978108 3.6 HDGF FOXA2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 ACIN1 NGDN PRMT5 RNF31 RNA5SP383 HOMEZ IPO4 NOP9 THTPA RBM23
GH14H023953 1.1 ENCODE 18.1 -345.8 -345750 2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ACIN1 TSSK4 DHRS4 DHRS4-AS1 SDR39U1 PABPN1 NGDN RNF31 SLC22A17 RNA5SP383
GH14H024277 1.4 FANTOM5 Ensembl ENCODE 12.9 -20.3 -20254 5.2 CTCF PKNOX1 NFIB MAX EBF1 RAD21 RELA RFX5 POLR2A EED DHRS1 TINF2 NOP9 LTB4R2 CIDEB LTB4R GMPR2 NEDD8 NEDD8-MDP1 MDP1
GH14H024091 1.7 Ensembl ENCODE dbSUPER 9.8 -206.2 -206208 6.5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 RNA5SP383 NGDN IPO4 ACIN1 NYNRIN NFATC4 KHNYN RNF31 SLC7A8 TINF2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOP9 on UCSC Golden Path with GeneCards custom track

Promoters for NOP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066854 46 1401 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS PAF1

Genomic Locations for NOP9 Gene

Genomic Locations for NOP9 Gene
chr14:24,299,854-24,309,126
(GRCh38/hg38)
Size:
9,273 bases
Orientation:
Plus strand
chr14:24,769,068-24,778,330
(GRCh37/hg19)

Genomic View for NOP9 Gene

Genes around NOP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP9 Gene

Proteins for NOP9 Gene

  • Protein details for NOP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U38-NOP9_HUMAN
    Recommended name:
    Nucleolar protein 9
    Protein Accession:
    Q86U38
    Secondary Accessions:
    • A8MY76
    • Q8IVF0
    • Q8TBS6

    Protein attributes for NOP9 Gene

    Size:
    636 amino acids
    Molecular mass:
    69438 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC23117.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOP9 Gene

Post-translational modifications for NOP9 Gene

  • Ubiquitination at Lys120 and Lys611
  • Modification sites at PhosphoSitePlus

Other Protein References for NOP9 Gene

No data available for DME Specific Peptides for NOP9 Gene

Domains & Families for NOP9 Gene

Gene Families for NOP9 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NOP9 Gene

Suggested Antigen Peptide Sequences for NOP9 Gene

Graphical View of Domain Structure for InterPro Entry

Q86U38

UniProtKB/Swiss-Prot:

NOP9_HUMAN :
  • Belongs to the NOP9 family.
Family:
  • Belongs to the NOP9 family.
genes like me logo Genes that share domains with NOP9: view

Function for NOP9 Gene

Phenotypes From GWAS Catalog for NOP9 Gene

Gene Ontology (GO) - Molecular Function for NOP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOP9: view
genes like me logo Genes that share phenotypes with NOP9: view

Animal Model Products

CRISPR Products

miRNA for NOP9 Gene

miRTarBase miRNAs that target NOP9

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP9 Gene

Localization for NOP9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOP9 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with NOP9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NOP9 Gene

Pathways & Interactions for NOP9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NOP9: view

No data available for Pathways by source and SIGNOR curated interactions for NOP9 Gene

Drugs & Compounds for NOP9 Gene

No Compound Related Data Available

Transcripts for NOP9 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP9 Gene

No ASD Table

Relevant External Links for NOP9 Gene

GeneLoc Exon Structure for
NOP9
ECgene alternative splicing isoforms for
NOP9

Expression for NOP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOP9 Gene

Protein differential expression in normal tissues from HIPED for NOP9 Gene

This gene is overexpressed in Bone (15.1), Lung (11.1), and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOP9 Gene



Protein tissue co-expression partners for NOP9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOP9 Gene:

NOP9

Evidence on tissue expression from TISSUES for NOP9 Gene

  • Lung(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NOP9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOP9 Gene

Orthologs for NOP9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOP9 34 33
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia C10H14orf21 34 33
  • 88.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NOP9 33
  • 87.12 (n)
C14ORF21 34
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nop9 33
  • 83.49 (n)
mouse
(Mus musculus)
Mammalia Nop9 16 34 33
  • 83.02 (n)
oppossum
(Monodelphis domestica)
Mammalia NOP9 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101750118 33
  • 51.39 (n)
NOP9 34
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOP9 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nop9 33
  • 56.81 (n)
Str.6747 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69156 33
zebrafish
(Danio rerio)
Actinopterygii LOC100332577 33
  • 49.28 (n)
AL954696.1 34
  • 35 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011440 33
  • 42.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11123 33 34
  • 42.71 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR046W 33
  • 38.59 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP9 33 34 36
  • 38.05 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13685g 33
  • 38.01 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PUM23 33
  • 39.14 (n)
rice
(Oryza sativa)
Liliopsida Os10g0390100 33
  • 39.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nop9 33
  • 36.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToOne
Species where no ortholog for NOP9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOP9 Gene

ENSEMBL:
Gene Tree for NOP9 (if available)
TreeFam:
Gene Tree for NOP9 (if available)

Paralogs for NOP9 Gene

(1) SIMAP similar genes for NOP9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NOP9: view

No data available for Paralogs for NOP9 Gene

Variants for NOP9 Gene

Sequence variations from dbSNP and Humsavar for NOP9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs374412139 A breast cancer sample 24,305,061(+) CAAGC(A/G)GAGGC intron-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
VAR_036456 A breast cancer sample
rs1000076387 -- 24,308,808(+) CCCAG(A/C)TTCCC upstream-variant-2KB, utr-variant-3-prime, utr-variant-5-prime
rs1000203991 -- 24,299,737(+) CAGAG(G/T)CCCAG upstream-variant-2KB, utr-variant-5-prime
rs1000519268 -- 24,309,126(+) TGATC(A/C)CCCTG intron-variant, upstream-variant-2KB, utr-variant-3-prime, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NOP9 Gene

Variant ID Type Subtype PubMed ID
nsv564060 CNV loss 21841781
nsv564059 CNV loss 21841781
nsv564058 CNV loss 21841781
esv3633804 CNV loss 21293372
esv2669637 CNV deletion 23128226

Variation tolerance for NOP9 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.16; 84.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP9 Gene

Disorders for NOP9 Gene

Relevant External Links for NOP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOP9

No disorders were found for NOP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP9 Gene

Publications for NOP9 Gene

  1. Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains. (PMID: 21653694) Dong S … Wang Z (The Journal of biological chemistry 2011) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 60

Products for NOP9 Gene

Sources for NOP9 Gene

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