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Aliases for NOP9 Gene

Aliases for NOP9 Gene

  • NOP9 Nucleolar Protein 2 3 5
  • C14orf21 3 4
  • Pumilio Domain-Containing Protein C14orf21 3
  • NOP9 Nucleolar Protein Homolog (Yeast) 2
  • Chromosome 14 Open Reading Frame 21 2
  • NOP9 Nucleolar Protein Homolog 3
  • KIAA2021 4

External Ids for NOP9 Gene

Previous HGNC Symbols for NOP9 Gene

  • C14orf21

Previous GeneCards Identifiers for NOP9 Gene

  • GC14P024770

Summaries for NOP9 Gene

GeneCards Summary for NOP9 Gene

NOP9 (NOP9 Nucleolar Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP9 Gene

Genomics for NOP9 Gene

Regulatory Elements for NOP9 Gene

Enhancers for NOP9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOP9 on UCSC Golden Path with GeneCards custom track

Promoters for NOP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOP9 Gene

24,299,854 bp from pter
24,309,126 bp from pter
9,273 bases
Plus strand

Genomic View for NOP9 Gene

Genes around NOP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP9 Gene

Proteins for NOP9 Gene

  • Protein details for NOP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 9
    Protein Accession:
    Secondary Accessions:
    • A8MY76
    • Q8IVF0
    • Q8TBS6

    Protein attributes for NOP9 Gene

    636 amino acids
    Molecular mass:
    69438 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC23117.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP9 Gene


neXtProt entry for NOP9 Gene

Proteomics data for NOP9 Gene at MOPED

Post-translational modifications for NOP9 Gene

  • Ubiquitination at Lys 120 and Lys 611
  • Modification sites at PhosphoSitePlus

Other Protein References for NOP9 Gene

No data available for DME Specific Peptides for NOP9 Gene

Domains & Families for NOP9 Gene

Protein Domains for NOP9 Gene

Suggested Antigen Peptide Sequences for NOP9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NOP9 family.
  • Contains 6 pumilio repeats.
  • Belongs to the NOP9 family.
  • Contains 6 pumilio repeats.
genes like me logo Genes that share domains with NOP9: view

No data available for Gene Families for NOP9 Gene

Function for NOP9 Gene

genes like me logo Genes that share phenotypes with NOP9: view

Animal Model Products

CRISPR Products

miRNA for NOP9 Gene

miRTarBase miRNAs that target NOP9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP9 Gene

Localization for NOP9 Gene

Subcellular locations from

Jensen Localization Image for NOP9 Gene COMPARTMENTS Subcellular localization image for NOP9 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NOP9 Gene

Pathways & Interactions for NOP9 Gene

SuperPathways for NOP9 Gene

No Data Available

Interacting Proteins for NOP9 Gene

Gene Ontology (GO) - Biological Process for NOP9 Gene


No data available for Pathways by source and SIGNOR curated interactions for NOP9 Gene

Drugs & Compounds for NOP9 Gene

No Compound Related Data Available

Transcripts for NOP9 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NOP9 Gene

No ASD Table

Relevant External Links for NOP9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOP9 Gene

mRNA expression in normal human tissues for NOP9 Gene

Protein differential expression in normal tissues from HIPED for NOP9 Gene

This gene is overexpressed in Bone (15.1), Lung (11.1), and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOP9 Gene

genes like me logo Genes that share expression patterns with NOP9: view

Protein tissue co-expression partners for NOP9 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOP9 Gene

Orthologs for NOP9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C10H14orf21 35
  • 88.05 (n)
  • 88.68 (a)
C10H14orf21 36
  • 89 (a)
(Canis familiaris)
Mammalia NOP9 35
  • 87.12 (n)
  • 86.28 (a)
C14ORF21 36
  • 86 (a)
(Mus musculus)
Mammalia Nop9 35
  • 83.02 (n)
  • 82.08 (a)
Nop9 16
Nop9 36
  • 82 (a)
(Pan troglodytes)
Mammalia NOP9 35
  • 99.37 (n)
  • 99.05 (a)
NOP9 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nop9 35
  • 83.49 (n)
  • 82.65 (a)
(Monodelphis domestica)
Mammalia NOP9 36
  • 74 (a)
(Gallus gallus)
Aves LOC101750118 35
  • 51.39 (n)
  • 42.19 (a)
NOP9 36
  • 41 (a)
(Anolis carolinensis)
Reptilia NOP9 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nop9 35
  • 56.81 (n)
  • 50.09 (a)
Str.6747 35
African clawed frog
(Xenopus laevis)
Amphibia MGC69156 35
(Danio rerio)
Actinopterygii LOC100332577 35
  • 49.28 (n)
  • 37.05 (a)
AL954696.1 36
  • 35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011440 35
  • 42.73 (n)
  • 28.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11123 35
  • 42.71 (n)
  • 32.16 (a)
CG11123 36
  • 23 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR046W 35
  • 38.59 (n)
  • 22.51 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13685g 35
  • 38.01 (n)
  • 25.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP9 35
  • 38.05 (n)
  • 24.15 (a)
NOP9 36
  • 19 (a)
NOP9 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PUM23 35
  • 39.14 (n)
  • 26.52 (a)
(Oryza sativa)
Liliopsida Os10g0390100 35
  • 39.88 (n)
  • 28.52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nop9 35
  • 36.9 (n)
  • 23.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for NOP9:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOP9 Gene

Gene Tree for NOP9 (if available)
Gene Tree for NOP9 (if available)

Paralogs for NOP9 Gene

(1) SIMAP similar genes for NOP9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NOP9: view

No data available for Paralogs for NOP9 Gene

Variants for NOP9 Gene

Sequence variations from dbSNP and Humsavar for NOP9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs4280164 - 24,302,079(+) CCTGA(A/G)TACTC reference, missense
VAR_036456 A breast cancer sample
VAR_036457 A breast cancer sample
VAR_051612 -
rs3052629 -- 24,303,402(+) ttttt(-/TT)gagac intron-variant, downstream-variant-500B

Variation tolerance for NOP9 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.16; 84.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NOP9 Gene

Disorders for NOP9 Gene

Relevant External Links for NOP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP9 Gene

Publications for NOP9 Gene

  1. Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains. (PMID: 21653694) Dong S. … Wang Z. (J. Biol. Chem. 2011) 2 3 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for NOP9 Gene

Sources for NOP9 Gene