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NOP58 Gene

protein-coding   GIFtS: 57
GCID: GC02P203130

NOP58 Ribonucleoprotein

(Previous name: NOP58 ribonucleoprotein homolog (yeast))
  Search for NOP58
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NOP58 Ribonucleoprotein1 2     NOP58 Ribonucleoprotein Homolog2
Nucleolar Protein 52 3     Nucleolar Protein 582
NOP52 3     Nucleolar Protein NOP5/NOP582
NOP58 Ribonucleoprotein Homolog (Yeast)1     NOL53
NOP5/NOP582     

External Ids:    HGNC: 299261   Entrez Gene: 516022   Ensembl: ENSG000000550447   UniProtKB: Q9Y2X33   

Export aliases for NOP58 gene to outside databases

Previous GC identifers: GC02P202839 GC02P194979


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NOP58 Gene:
NOP58 (NOP58 ribonucleoprotein) is a protein-coding gene. GO annotations related to this gene include snoRNA binding.

UniProtKB/Swiss-Prot: NOP58_HUMAN, Q9Y2X3
Function: Required for 60S ribosomal subunit biogenesis (By similarity)

Gene Wiki entry for NOP58 (NOP5/NOP58) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOP58 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOP58 promoter sequence
   Search Chromatin IP Primers for NOP58

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOP58


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

NOP58 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOP58 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P203130:  view genomic region     (about GC identifiers)

Start:
203,130,439 bp from pter      End:
203,168,389 bp from pter
Size:
37,951 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NOP58_HUMAN, Q9Y2X3 (See protein sequence)
Recommended Name: Nucleolar protein 58  
Size: 529 amino acids; 59578 Da
Subunit: Interacts with NOLC1/Nopp140 (By similarity). Component of box C/D small nucleolar ribonucleoprotein
(snoRNP) particles
Secondary accessions: Q53SA4 Q6PK08 Q9P036 Q9UFN3

Explore the universe of human proteins at neXtProt for NOP58: NX_Q9Y2X3

Explore proteomics data for NOP58 at MOPED

Post-translational modifications: 

  • Sumoylation is essential for high-affinity binding to snoRNAs1
  • Ubiquitination2 at Lys206, Lys221, Lys310, Lys323, Lys337, Lys365
  • Modification sites at PhosphoSitePlus

  • See NOP58 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057018.1  
    ENSEMBL proteins: 
     ENSP00000264279   ENSP00000388905   ENSP00000388126  

    NOP58 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for NOP58
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    Novus Biologicals NOP58 Protein
    Novus Biologicals NOP58 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOP58

     
    Search eBioscience for Proteins for NOP58 

    NOP58 Antibody Products:

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    Cloud-Clone Corp. ELISAs for NOP58
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    Search eBioscience for ELISAs for NOP58 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002687 Nop_dom
     IPR012974 NOP5_N
     IPR012976 NOSIC

    Graphical View of Domain Structure for InterPro Entry Q9Y2X3

    ProtoNet protein and cluster: Q9Y2X3

    3 Blocks protein domains:
    IPB002687 Pre-mRNA processing ribonucleoprotein
    IPB012974 NOP5
    IPB012976 NOSIC


    UniProtKB/Swiss-Prot: NOP58_HUMAN, Q9Y2X3
    Similarity: Belongs to the NOP5/NOP56 family
    Similarity: Contains 1 Nop domain


    Find genes that share domains with NOP58           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOP58_HUMAN, Q9Y2X3
    Function: Required for 60S ribosomal subunit biogenesis (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17636026
    GO:0030515snoRNA binding IDA17636026
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NOP58           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for NOP58:
     Decreased Hepatitis C virus re  Decreased viability of wild-ty  Nuclear 60S biogenesis defects  Nucleoplasmic pre-40S maturati 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOP58
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOP58
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOP58

    miRNA
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    miRTarBase miRNAs that target NOP58:
    hsa-mir-221-3p (MIRT046864)

    Block miRNA regulation of human, mouse, rat NOP58 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NOP58:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmidNOP58 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NOP58

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOP58

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    Browse ESI BIO Cell Lines and PureStem Progenitors for NOP58 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOP58


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOP58_HUMAN, Q9Y2X3: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus TAS10925205
    GO:0005732small nucleolar ribonucleoprotein complex IDA17636026
    GO:0005737cytoplasm IDA--
    GO:0015030Cajal body IDA16687569

    Find genes that share ontologies with NOP58           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NOP58 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with NOP58           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for NOP58):
        Ribosome biogenesis in eukaryotes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOP58
    Interactions:

        Search GeneGlobe Interaction Network for NOP58

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOP58 (Q9Y2X31, 2, 3 ENSP000002642794) via UniProtKB, MINT, STRING, and/or I2D (see all 421)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing TAS10925205
    GO:0006608snRNP protein import into nucleus ISS10679015
    GO:0016049cell growth TAS10925205

    Find genes that share ontologies with NOP58           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOP58



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOP58 gene: 
    NM_015934.3  

    Unigene Cluster for NOP58:

    NOP58 ribonucleoprotein
    Hs.471104  [show with all ESTs]
    Unigene Representative Sequence: NM_015934
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264279(uc002uzb.3) ENST00000426814 ENST00000488403(uc010zhv.1)
    ENST00000492740 ENST00000472050 ENST00000467734 ENST00000492688 ENST00000478941
    ENST00000433543 ENST00000478508
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NOP58 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NOP58:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmidNOP58 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NOP58
    Predesigned siRNA for gene silencing in human, mouse, rat NOP58
    Clone
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    OriGene clones in human, mouse for NOP58 (see all 6)
    OriGene ORF clones in mouse, rat for NOP58
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOP58 (NM_015934)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOP58
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOP58
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NOP58
    OriGene qSTAR qPCR primer pairs in human, mouse for NOP58
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOP58
      QuantiTect SYBR Green Assays in human, mouse, rat NOP58
      QuantiFast Probe-based Assays in human, mouse, rat NOP58

    Additional mRNA sequence: 

    AF123534.1 AF161469.1 AF263608.1 AK023975.1 AK300844.1 AK307396.1 AL117554.1 BC001707.1 
    BC009306.2 BC018805.1 BC032592.2 

    20 DOTS entries:

    DT.109893  DT.75160265  DT.120937859  DT.92446016  DT.120937862  DT.120937895  DT.100822922  DT.92446010 
    DT.100058877  DT.100889290  DT.120937865  DT.97860485  DT.100725164  DT.120937864  DT.75192847  DT.91962525 
    DT.40132877  DT.92338234  DT.95114801  DT.95114803 

    Selected AceView cDNA sequences (see all 279):

    BM761515 BE220269 BC018805 BF510536 AI564329 BG744948 AW778951 BF445154 
    AF263608 BQ960327 CA439666 BX354341 BC001707 BE018636 CB159666 CR618609 
    BU160755 CB123824 BU619851 BG027973 BM449809 BE018531 BM994688 BQ223313 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NOP58 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                                -           -     -                       -                 -                                                     -         
    SP2:                                -           -     -           -     -     -     -           -                                                               
    SP3:                                -           -     -                                                                                                         
    SP4:                                -           -                                                                                                               
    SP5:                                -           -     -                       -                                                                                 

    ExUns: 17a · 17b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for NOP58

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOP58 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCAGCACA
    NOP58 Expression
    About this image


    NOP58 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    NOP58 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOP58 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471104

    UniProtKB/Swiss-Prot: NOP58_HUMAN, Q9Y2X3
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for NOP58
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOP58
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    QuantiFast Probe-based Assays in human, mouse, rat NOP58
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOP58

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOP58 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nop581 , 5 NOP58 ribonucleoprotein homolog (yeast)5
    NOP58 ribonucleoprotein1
    91.3(n)1
    95.46(a)1
      1 (30.38 cM)5
    559891  NM_018868.21  NP_061356.21 
     596850065 
    chicken
    (Gallus gallus)
    Aves NOP581 NOP58 ribonucleoprotein homolog (yeast) 76.55(n)
    82.3(a)
      424087  XM_421942.4  XP_421942.1 
    lizard
    (Anolis carolinensis)
    Reptilia NOP586
    NOP58 ribonucleoprotein
    83(a)
    1 ↔ 1
    GL343208.1(3816899-3834038)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985582 similar to nucleolar protein NOP5/NOP58 75.54(n)    BC041223.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.2822 Danio rerio, clone IMAGE2639288, mRNA, partial cds 74.68(n)    BC061961.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nop51 nop5 61.17(n)
    66.82(a)
      33966  NM_058064.5  NP_477412.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nol-51 nol-5 59.09(n)
    58.13(a)
      171901  NM_058733.6  NP_491134.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOP58(YOR310C)4
    NOP581
    Protein involved in pre-rRNA processing, 18S rRNA synthesis, more4
    NOP581
    54.96(n)1
    50.67(a)1
      15(898360-896825)4
    8544871, 4  NP_014955.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G050601 AT3G05060 60.24(n)
    60.98(a)
      819668  NM_111378.3  NP_187157.1 
    rice
    (Oryza sativa)
    Liliopsida AK073164.12   -- 72.61(n)    AK073164.1 


    ENSEMBL Gene Tree for NOP58 (if available)
    TreeFam Gene Tree for NOP58 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOP58 gene
    1 SIMAP similar gene for NOP58 using alignment to 3 protein entries:     NOP58_HUMAN (see all proteins):
    NOP56

    Find genes that share paralogs with NOP58           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NOP58
    PGOHUM00000248904


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOP58 (see all 653)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916264021,2
    --203128583(+) GGGCCC/TGGGAA 1 -- us2k10--------
    rs1849188231,2
    C--203128651(+) TTAATC/TCCAGT 1 -- us2k10--------
    rs568695591,2
    C,F--203128739(+) GCTCAC/TGCCTG 1 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1897533231,2
    --203128775(+) GGTGGA/GTGGAT 1 -- us2k10--------
    rs356896011,2
    C,F--203128816(+) GACCAT/GCATGG 1 -- us2k16Minor allele frequency- G:0.20NA WA CSA EA 247
    rs1499632031,2
    C--203128958(+) ATCATA/GCCACT 1 -- us2k10--------
    rs1450582421,2
    --203128996(+) AACTCC/TGTCTC 1 -- us2k10--------
    rs350173601,2
    C--203129034(+) AAAAA-/AGACAT 1 -- us2k10--------
    rs1931326291,2
    --203129060(+) TGGGGC/TCATTT 1 -- us2k10--------
    rs768710941,2
    C--203129119(+) TAATAA/CTTCAT 1 -- us2k13Minor allele frequency- C:0.32NA EA 242

    HapMap Linkage Disequilibrium report for NOP58 (203130439 - 203168389 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NOP58:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875711CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOP58
    DNA2.0 Custom Variant and Variant Library Synthesis for NOP58

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    1 disease from the University of Copenhagen DISEASES database for NOP58:
    Kennedy's disease

    Find genes that share disorders with NOP58           About GenesLikeMe


    Export disorders for NOP58 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOP58 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with NOP58)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel PDGF-induced human gene. (PubMed id 10925205)1, 2, 3 Nelson S.A.... LaRochelle W.J. (Gene 2000)
    2. Human Nop5/Nop58 is a component common to the box C/D small nucleolar ribonucleoproteins. (PubMed id 10606270)1, 2, 3 Lyman S.K.... Baserga S.J. (RNA 1999)
    3. A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58. (PubMed id 20797632)1, 2 Westman B.J....Lamond A.I. (Mol. Cell 2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 51602 HGNC: 29926 AceView: NOP5\/NOP58 Ensembl:ENSG00000055044 euGenes: HUgn51602
    ECgene: NOP58 Kegg: 51602 H-InvDB: NOP58

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NOP58 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NOP58 gene:
    Search GeneIP for patents involving NOP58

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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