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Aliases for NOP58 Gene

Aliases for NOP58 Gene

  • NOP58 Ribonucleoprotein 2 3
  • Nucleolar Protein 5 3 4
  • NOP5 3 4
  • NOP58 Ribonucleoprotein Homolog (Yeast) 2
  • NOP58 Ribonucleoprotein Homolog 3
  • Nucleolar Protein NOP5/NOP58 3
  • NOP5/NOP58 3
  • HSPC120 3
  • NOL5 4

External Ids for NOP58 Gene

Previous GeneCards Identifiers for NOP58 Gene

  • GC02P202839
  • GC02P203130
  • GC02P194979

Summaries for NOP58 Gene

Entrez Gene Summary for NOP58 Gene

  • The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]

GeneCards Summary for NOP58 Gene

NOP58 (NOP58 Ribonucleoprotein) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding and snoRNA binding.

UniProtKB/Swiss-Prot for NOP58 Gene

  • Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs.

Gene Wiki entry for NOP58 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP58 Gene

Genomics for NOP58 Gene

Regulatory Elements for NOP58 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NOP58 Gene

Chromosome:
2
Start:
202,265,716 bp from pter
End:
202,303,666 bp from pter
Size:
37,951 bases
Orientation:
Plus strand

Genomic View for NOP58 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOP58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP58 Gene

Proteins for NOP58 Gene

  • Protein details for NOP58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2X3-NOP58_HUMAN
    Recommended name:
    Nucleolar protein 58
    Protein Accession:
    Q9Y2X3
    Secondary Accessions:
    • Q53SA4
    • Q6PK08
    • Q9P036
    • Q9UFN3

    Protein attributes for NOP58 Gene

    Size:
    529 amino acids
    Molecular mass:
    59578 Da
    Quaternary structure:
    • Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins NHP2L1, NOP56, NOP58 and FBL assemble stepwise onto the snoRNA. Interacts with NOLC1/Nopp140. Interacts with NUFIP1, RUVBL1 AND RUVBL2; RUVBL1:RUVBL2 seem to bridge the association of NOP58 with NUFIP1. Interacts with PIH1D1 (PubMed:17636026).

neXtProt entry for NOP58 Gene

Proteomics data for NOP58 Gene at MOPED

Post-translational modifications for NOP58 Gene

  • Sumoylation is essential for high-affinity binding to snoRNAs.
  • Ubiquitination at Lys 206, Lys 221, Lys 310, Lys 323, Lys 337, and Lys 365
  • Modification sites at PhosphoSitePlus

Other Protein References for NOP58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOP58 Gene

Domains & Families for NOP58 Gene

Protein Domains for NOP58 Gene

Suggested Antigen Peptide Sequences for NOP58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2X3

UniProtKB/Swiss-Prot:

NOP58_HUMAN :
  • Contains 1 Nop domain.
  • Belongs to the NOP5/NOP56 family.
Domain:
  • Contains 1 Nop domain.
Family:
  • Belongs to the NOP5/NOP56 family.
genes like me logo Genes that share domains with NOP58: view

No data available for Gene Families for NOP58 Gene

Function for NOP58 Gene

Molecular function for NOP58 Gene

UniProtKB/Swiss-Prot Function:
Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs.

Gene Ontology (GO) - Molecular Function for NOP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17636026
GO:0030515 snoRNA binding IDA 17636026
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOP58: view
genes like me logo Genes that share phenotypes with NOP58: view

Animal Model Products

CRISPR Products

miRNA for NOP58 Gene

miRTarBase miRNAs that target NOP58

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOP58

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP58 Gene

Localization for NOP58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP58 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOP58 Gene COMPARTMENTS Subcellular localization image for NOP58 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NOP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus TAS 10925205
GO:0005732 small nucleolar ribonucleoprotein complex IDA 17636026
GO:0005737 cytoplasm IDA --
GO:0015030 Cajal body IDA 16687569
genes like me logo Genes that share ontologies with NOP58: view

Pathways & Interactions for NOP58 Gene

genes like me logo Genes that share pathways with NOP58: view

Pathways by source for NOP58 Gene

1 KEGG pathway for NOP58 Gene

Gene Ontology (GO) - Biological Process for NOP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000154 rRNA modification IBA --
GO:0006364 rRNA processing TAS 10925205
GO:0006608 snRNP protein import into nucleus ISS 10679015
GO:0016049 cell growth TAS 10925205
genes like me logo Genes that share ontologies with NOP58: view

No data available for SIGNOR curated interactions for NOP58 Gene

Drugs & Compounds for NOP58 Gene

No Compound Related Data Available

Transcripts for NOP58 Gene

Unigene Clusters for NOP58 Gene

NOP58 ribonucleoprotein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOP58

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP58 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8:
SP9:

ExUns: 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for NOP58 Gene

GeneLoc Exon Structure for
NOP58
ECgene alternative splicing isoforms for
NOP58

Expression for NOP58 Gene

mRNA expression in normal human tissues for NOP58 Gene

Protein differential expression in normal tissues from HIPED for NOP58 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), CD8 Tcells (7.5), Tlymphocyte (6.9), and Blymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOP58 Gene



SOURCE GeneReport for Unigene cluster for NOP58 Gene Hs.471104

mRNA Expression by UniProt/SwissProt for NOP58 Gene

Q9Y2X3-NOP58_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with NOP58: view

Protein tissue co-expression partners for NOP58 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NOP58 Gene

Orthologs for NOP58 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOP58 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOP58 35
  • 91.68 (n)
  • 96.03 (a)
NOP58 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOP58 35
  • 91.18 (n)
  • 95.65 (a)
NOP58 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nop58 35
  • 91.3 (n)
  • 95.46 (a)
Nop58 16
Nop58 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOP58 35
  • 99.68 (n)
  • 99.43 (a)
NOP58 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nop58 35
  • 90.55 (n)
  • 95.65 (a)
oppossum
(Monodelphis domestica)
Mammalia NOP58 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOP58 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOP58 35
  • 76.55 (n)
  • 82.3 (a)
NOP58 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOP58 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75641 35
nop58 35
  • 70.26 (n)
  • 75.24 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398558 35
zebrafish
(Danio rerio)
Actinopterygii Dr.282 35
nop58 35
  • 71.6 (n)
  • 81.9 (a)
nop58 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14025 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002171 35
  • 59.35 (n)
  • 64.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta nop5 35
  • 61.17 (n)
  • 66.82 (a)
nop5 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nol-5 35
  • 59.09 (n)
  • 58.13 (a)
nol-5 36
  • 55 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR328C 35
  • 54.27 (n)
  • 50.81 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08613g 35
  • 55.09 (n)
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP58 35
  • 54.96 (n)
  • 50.67 (a)
NOP58 36
  • 47 (a)
OneToOne
NOP58 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G05060 35
  • 60.24 (n)
  • 60.98 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2939 35
rice
(Oryza sativa)
Liliopsida Os03g0350300 35
  • 61.79 (n)
  • 60.09 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.721 35
corn
(Zea mays)
Liliopsida Zm.10383 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14972 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03396 35
  • 52.81 (n)
  • 52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC23G3.06 35
  • 58.12 (n)
  • 57.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToOne
Species with no ortholog for NOP58:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NOP58 Gene

ENSEMBL:
Gene Tree for NOP58 (if available)
TreeFam:
Gene Tree for NOP58 (if available)

Paralogs for NOP58 Gene

(1) SIMAP similar genes for NOP58 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NOP58 Gene

genes like me logo Genes that share paralogs with NOP58: view

No data available for Paralogs for NOP58 Gene

Variants for NOP58 Gene

Sequence variations from dbSNP and Humsavar for NOP58 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15160 -- 202,297,502(-) GTCTT(A/C)CAAAG reference, stop-gained
rs954233 -- 202,278,920(-) TCTTC(A/C)TTCAG intron-variant
rs1054446 -- 202,303,450(+) AATTA(A/C/G/T)GATTA utr-variant-3-prime
rs1400002 -- 202,279,132(-) GAGTT(G/T)GAATA intron-variant
rs1811791 -- 202,299,165(+) ATGTT(A/G)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOP58 Gene

Variant ID Type Subtype PubMed ID
nsv875711 CNV Loss 21882294

Variation tolerance for NOP58 Gene

Residual Variation Intolerance Score: 7.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOP58 Gene

HapMap Linkage Disequilibrium report
NOP58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP58 Gene

Disorders for NOP58 Gene

Relevant External Links for NOP58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOP58
genes like me logo Genes that share disorders with NOP58: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP58 Gene

Publications for NOP58 Gene

  1. Isolation and characterization of a novel PDGF-induced human gene. (PMID: 10925205) Nelson S.A. … LaRochelle W.J. (Gene 2000) 2 67
  2. Human Nop5/Nop58 is a component common to the box C/D small nucleolar ribonucleoproteins. (PMID: 10606270) Lyman S.K. … Baserga S.J. (RNA 1999) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for NOP58 Gene

Sources for NOP58 Gene

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