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Aliases for NOP53 Gene

Aliases for NOP53 Gene

  • NOP53 Ribosome Biogenesis Factor 2 3
  • GLTSCR2 3 4 5
  • Glioma Tumor Suppressor Candidate Region Gene 2 2 5
  • P60 3 4
  • Glioma Tumor Suppressor Candidate Region Gene 2 Protein 3
  • Protein Interacting With Carboxyl Terminus 1 3
  • PICT-1 3
  • PICT1 3

External Ids for NOP53 Gene

Previous HGNC Symbols for NOP53 Gene


Summaries for NOP53 Gene

GeneCards Summary for NOP53 Gene

NOP53 (NOP53 Ribosome Biogenesis Factor) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and Influenza A.

Gene Wiki entry for NOP53 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP53 Gene

Genomics for NOP53 Gene

Regulatory Elements for NOP53 Gene

Enhancers for NOP53 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G047657 1.7 Ensembl ENCODE dbSUPER 16.6 -82.3 -82259 10.6 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D BICRA NOP53 ZNF541 SNORD23 SULT2A1 ENSG00000278999 BICRA-AS1
GH19G047598 2 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -145.3 -145303 4.2 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 CBX5 ZNF541 NAPA NOP53 SNORD23 BBC3 BICRA INAFM1 GC19P047605 GC19P047592
GH19G047741 1.4 ENCODE dbSUPER 13.6 -1.6 -1601 5.0 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZC3H4 SELENOW BICRA CA11 C19orf68 NOP53 SNORD23 NTN5 GRWD1 NOP53-AS1
GH19G047471 1.3 Ensembl ENCODE 10.8 -273.5 -273474 1.1 ARNT ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF416 KLF7 KLF13 SP3 PPP5D1 ZC3H4 EHD2 C19orf68 SNORD23 NOP53 SLC8A2 MEIS3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOP53 on UCSC Golden Path with GeneCards custom track

Promoters for NOP53 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NOP53 Gene

47,745,522 bp from pter
47,757,066 bp from pter
11,545 bases
Plus strand

Genomic View for NOP53 Gene

Genes around NOP53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP53 Gene

Proteins for NOP53 Gene

  • Protein details for NOP53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glioma tumor suppressor candidate region gene 2 protein
    Protein Accession:
    Secondary Accessions:
    • Q9BTC6
    • Q9HAX6
    • Q9NPP1
    • Q9NPR4
    • Q9UFI2

    Protein attributes for NOP53 Gene

    478 amino acids
    Molecular mass:
    54389 Da
    Quaternary structure:
    • Interacts with HSV-1 early proteins ICP22 and ICP0.

neXtProt entry for NOP53 Gene

Post-translational modifications for NOP53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOP53 Gene

No data available for DME Specific Peptides for NOP53 Gene

Domains & Families for NOP53 Gene

Protein Domains for NOP53 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GLTSCR2 family.
  • Belongs to the GLTSCR2 family.
genes like me logo Genes that share domains with NOP53: view

No data available for Gene Families for NOP53 Gene

Function for NOP53 Gene

Gene Ontology (GO) - Molecular Function for NOP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 15355975
GO:0008097 5S rRNA binding IDA 24120868
genes like me logo Genes that share ontologies with NOP53: view
genes like me logo Genes that share phenotypes with NOP53: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP53 Gene

Localization for NOP53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP53 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOP53 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NOP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 10196275
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 24923447
GO:0005730 nucleolus IDA 24923447
GO:0005737 cytoplasm IDA 24923447
genes like me logo Genes that share ontologies with NOP53: view

Pathways & Interactions for NOP53 Gene

genes like me logo Genes that share pathways with NOP53: view

Pathways by source for NOP53 Gene

2 Cell Signaling Technology pathways for NOP53 Gene
1 KEGG pathway for NOP53 Gene

Gene Ontology (GO) - Biological Process for NOP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IMP 24120868
GO:0001932 regulation of protein phosphorylation IMP 15355975
GO:0008150 biological_process ND --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA --
GO:0032507 maintenance of protein location in cell IEA --
genes like me logo Genes that share ontologies with NOP53: view

No data available for SIGNOR curated interactions for NOP53 Gene

Drugs & Compounds for NOP53 Gene

No Compound Related Data Available

Transcripts for NOP53 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP53 Gene

No ASD Table

Relevant External Links for NOP53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOP53 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOP53 Gene:


mRNA Expression by UniProt/SwissProt for NOP53 Gene:

Tissue specificity: Expressed at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung.

Evidence on tissue expression from TISSUES for NOP53 Gene

  • Nervous system(4.6)
  • Muscle(4.5)
  • Eye(4.4)
  • Lung(4.3)
  • Skin(4.3)
  • Intestine(4.1)
  • Pancreas(3.8)
  • Kidney(3.1)
  • Stomach(3.1)
  • Blood(2.4)
  • Spleen(2.4)
  • Thyroid gland(2.4)
  • Lymph node(2.3)
  • Bone(2.2)
  • Liver(2.2)
  • Adrenal gland(2)
  • Bone marrow(2)
  • Heart(2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOP53 Gene

Orthologs for NOP53 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOP53 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLTSCR2 35 34
  • 99.09 (n)
(Canis familiaris)
Mammalia GLTSCR2 34 35
  • 86.15 (n)
(Bos Taurus)
Mammalia GLTSCR2 34 35
  • 85.36 (n)
(Mus musculus)
Mammalia Gltscr2 34 35
  • 81.24 (n)
Nop53 16
(Rattus norvegicus)
Mammalia Gltscr2 34
  • 80.61 (n)
(Monodelphis domestica)
Mammalia GLTSCR2 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia GLTSCR2 35
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
-- 35
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gltscr2 34
  • 55.21 (n)
Str.527 34
(Danio rerio)
Actinopterygii gltscr2 35 34
  • 56.75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000270 34
  • 48.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1785 35 34
  • 48.09 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y39B6A.33 34
  • 41.21 (n)
Y39B6A.33 35
  • 25 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR126W 34
  • 44.27 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11506g 34
  • 39.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP53 34
  • 37.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05233 34
  • 48.81 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rrp16 34
  • 39.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4906 35
  • 39 (a)
Species where no ortholog for NOP53 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOP53 Gene

Gene Tree for NOP53 (if available)
Gene Tree for NOP53 (if available)

Paralogs for NOP53 Gene Pseudogenes for NOP53 Gene

genes like me logo Genes that share paralogs with NOP53: view

No data available for Paralogs for NOP53 Gene

Variants for NOP53 Gene

Sequence variations from dbSNP and Humsavar for NOP53 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000011170 -- 47,745,891(+) GGGGT(G/T)GGGGG intron-variant
rs1000072814 -- 47,744,508(+) TGACG(A/C)AGATG upstream-variant-2KB
rs1000235016 -- 47,748,932(+) TGATG(A/C/T)GGGTG intron-variant
rs1000519381 -- 47,748,041(+) TCCCA(A/C/G)AGTGC intron-variant
rs1000585417 -- 47,748,755(+) CCGGA(C/G/T)GTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOP53 Gene

Variant ID Type Subtype PubMed ID
esv3644559 CNV gain 21293372
nsv1058351 CNV gain 25217958
nsv1059189 CNV gain 25217958

Variation tolerance for NOP53 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOP53 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP53 Gene

Disorders for NOP53 Gene

Relevant External Links for NOP53

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOP53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP53 Gene

Publications for NOP53 Gene

  1. The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death. (PMID: 17657248) Yim J.H. … Park J.H. (Cell Death Differ. 2007) 2 3 22 64
  2. Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. (PMID: 16971513) Okahara F. … Maehama T. (Mol. Biol. Cell 2006) 2 3 22 64
  3. A transcript map of the chromosome 19q-Arm glioma tumor suppressor region. (PMID: 10708517) Smith J.S. … Jenkins R.B. (Genomics 2000) 2 3 4 64
  4. A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type- specific manner and is recruited to the nucleus after infection. (PMID: 10196275) Bruni R. … Roizman B. (J. Virol. 1999) 3 4 22 64
  5. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. (PMID: 24120868) Sloan K.E. … Watkins N.J. (Cell Rep 2013) 2 3 64

Products for NOP53 Gene

Sources for NOP53 Gene

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