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NOP2 Gene

protein-coding   GIFtS: 51
GCID: GC12M006666

NOP2 Nucleolar Protein

(Previous names: nucleolar protein 1 (120kD), nucleolar protein 1, 120kDa,...)
(Previous symbol: NOL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NOP2 Nucleolar Protein1 2     Nucleolar Protein 2 Homolog (Yeast)1
NOL11 2 3 5     NOP1202
Nucleolar Protein 1, 120kDa1 2     NSUN12
Nucleolar Protein 2 Homolog2 3     NOL1/NOP2/Sun Domain Family, Member 12
Proliferating-Cell Nucleolar Antigen P1202 3     NOP2 Nucleolar Protein Homolog2
Proliferation-Associated Nucleolar Protein P1202 3     p1202
Member 11     Putative Ribosomal RNA Methyltransferase NOP22
NOP2 Nucleolar Protein Homolog (Yeast)1     EC 2.1.1.-3
NOP2/Sun Domain Family1     Nucleolar Protein 13
Nucleolar Protein 1 (120kD)1     EC 2.1.18

External Ids:    HGNC: 78671   Entrez Gene: 48392   Ensembl: ENSG000001116417   OMIM: 1640315   UniProtKB: P460873   

Export aliases for NOP2 gene to outside databases

Previous GC identifers: GC12M006537 GC12M006525


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NOP2 Gene:
NOP2 (NOP2 nucleolar protein) is a protein-coding gene. GO annotations related to this gene include S-adenosylmethionine-dependent methyltransferase activity and RNA binding. An important paralog of this gene is NSUN6.

UniProtKB/Swiss-Prot: NOP2_HUMAN, P46087
Function: May play a role in the regulation of the cell cycle and the increased nucleolar activity that is
associated with the cell proliferation. May act as ribosomal RNA methyltransferase

Gene Wiki entry for NOP2 (NOL1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOP2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Elk-1   SREBP-1c   E2F-2   SREBP-1b   SREBP-1a   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOP2 promoter sequence
   Search Chromatin IP Primers for NOP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

NOP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006666:  view genomic region     (about GC identifiers)

Start:
6,666,029 bp from pter      End:
6,677,857 bp from pter
Size:
11,829 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NOP2_HUMAN, P46087 (See protein sequence)
Recommended Name: Putative ribosomal RNA methyltransferase NOP2  
Size: 812 amino acids; 89302 Da
Subunit: Interaction with MCRS1
Developmental stage: Expressed in G1 and peaks during the early S phase of the cell cycle
Sequence caution: Sequence=AAA36398.1; Type=Frameshift; Positions=780; Sequence=CAA39119.1; Type=Frameshift;
Positions=780;
Secondary accessions: A1A4Z3 B3KPD6 Q05BA7 Q0P5S5 Q3KQS4 Q58F30
Alternative splicing: 4 isoforms:  P46087-1   P46087-2   P46087-3   P46087-4   

Explore the universe of human proteins at neXtProt for NOP2: NX_P46087

Explore proteomics data for NOP2 at MOPED

Post-translational modifications: 

  • Citrullinated by PADI4 (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for NOP2 (P46087)
     LLDAPCS  CCAPGGKT  GGFDRVLLD 


    See NOP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001028886.1  NP_001245237.1  NP_001245238.1  NP_001245239.1  NP_006161.2  

    ENSEMBL proteins: 
     ENSP00000444437   ENSP00000371858   ENSP00000439422   ENSP00000382392   ENSP00000313272  
     ENSP00000443150   ENSP00000440754   ENSP00000443035   ENSP00000442895   ENSP00000443585  
     ENSP00000441923   ENSP00000442742   ENSP00000445402  

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NOP2 

     
    antibodies-online proteins for NOP2 

     
    antibodies-online peptides for NOP2

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    antibodies-online antibodies for NOP2 (27 products) 

    NOP2 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for NOP2 
    antibodies-online kits for NOP2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NSUN: NOP2/Sun domain containing

    Selected InterPro protein domains (see all 6):
     IPR001678 Fmu/NOL1/Nop2p
     IPR018314 Fmu/NOL1/Nop2p_CS
     IPR023273 RCMT_NOP2
     IPR011023 Nop2p
     IPR012586 P120R

    Graphical View of Domain Structure for InterPro Entry P46087

    ProtoNet protein and cluster: P46087

    4 Blocks protein domains:
    IPB001678 Bacterial Sun/eukaryotic nucleolar Nop1/Nop2
    IPB006174 16S rRNA m5C967 methyltransferase
    IPB011023 Nop2p
    IPB012586 P120R


    UniProtKB/Swiss-Prot: NOP2_HUMAN, P46087
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family


    Find genes that share domains with NOP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOP2_HUMAN, P46087
    Function: May play a role in the regulation of the cell cycle and the increased nucleolar activity that is
    associated with the cell proliferation. May act as ribosomal RNA methyltransferase

         Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI12080348
    GO:0008168methyltransferase activity ----
    GO:0008757S-adenosylmethionine-dependent methyltransferase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NOP2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for NOP2:
     Decreased TP53 protein express  Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NOP2

    miRNA
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    miRTarBase miRNAs that target NOP2:
    hsa-mir-331-3p (MIRT043501), hsa-mir-1301-3p (MIRT036055), hsa-mir-26b-5p (MIRT029532), hsa-mir-361-5p (MIRT044113), hsa-mir-1226-3p (MIRT036456), hsa-mir-744-5p (MIRT037432), hsa-mir-128-3p (MIRT022000), hsa-mir-615-3p (MIRT040113), hsa-mir-935 (MIRT036665), hsa-mir-296-3p (MIRT038501), hsa-mir-100-5p (MIRT048389), hsa-mir-15a-5p (MIRT051348), hsa-mir-10a-5p (MIRT047626), hsa-mir-342-3p (MIRT043682), hsa-mir-101-3p (MIRT027322)

    Block miRNA regulation of human, mouse, rat NOP2 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOP2_HUMAN, P46087: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with NOP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOP2
    Interactions:

        GeneGlobe Interaction Network for NOP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOP2 (P460872, 3 ENSP000003823924) via UniProtKB, MINT, STRING, and/or I2D (see all 192)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K1Q132332, 3MINT-48339 I2D: score=2 
    TOP1P113873, ENSP000003545224I2D: score=3 STRING: ENSP00000354522
    EIF2AK2P195253, ENSP000002330574I2D: score=1 STRING: ENSP00000233057
    FBLP220873, ENSP000002218014I2D: score=1 STRING: ENSP00000221801
    HDAC5Q9UQL63, ENSP000002259834I2D: score=1 STRING: ENSP00000225983
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--
    GO:0008284positive regulation of cell proliferation TAS1394192
    GO:0032259methylation ----

    Find genes that share ontologies with NOP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOP2

    5 Novoseek inferred chemical compound relationships for NOP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-adenosylmethionine 33.6 1 14656444 (1)
    paraffin 31.7 4 7511264 (2), 9413739 (1), 9615190 (1)
    actinomycin d 29 4 7650069 (1), 9514935 (1)
    thymidine 8.24 1 9815576 (1)
    tyrosine 0.436 3 2256932 (1), 8663278 (1), 9147580 (1)



    Find genes that share compounds with NOP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOP2 gene (5 alternative transcripts): 
    NM_001033714.2  NM_001258308.1  NM_001258309.1  NM_001258310.1  NM_006170.3  

    Unigene Cluster for NOP2:

    NOP2 nucleolar protein
    Hs.534334  [show with all ESTs]
    Unigene Representative Sequence: NM_001258310
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000537442(uc021qty.1) ENST00000382421(uc021qtz.1) ENST00000545200(uc009zeq.2)
    ENST00000399466(uc021qtw.1) ENST00000322166(uc021qua.1) ENST00000541778(uc021qtx.1)
    ENST00000542015 ENST00000544630 ENST00000536506 ENST00000537708 ENST00000542919
    ENST00000542944 ENST00000542867 ENST00000400580 ENST00000536124 ENST00000538420
    ENST00000545492 ENST00000545915
    miRNA
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    hsa-miR-513a-3p hsa-miR-223*
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      QuantiTect SYBR Green Assays in human, mouse, rat NOP2
      QuantiFast Probe-based Assays in human, mouse, rat NOP2

    Additional mRNA sequence: 

    AK056208.1 AK129852.1 AK307582.1 BC000656.2 BC065257.1 BC082985.1 BC106072.1 BC128183.1 
    BC128184.1 M32110.1 X55504.1 

    16 DOTS entries:

    DT.415869  DT.97818161  DT.75190191  DT.100818843  DT.100818837  DT.100717250  DT.95133019  DT.92444365 
    DT.95133049  DT.121171240  DT.100818836  DT.121171232  DT.95133048  DT.100818835  DT.100818841  DT.75194478 

    Selected AceView cDNA sequences (see all 251):

    BU178650 BU157124 CF146219 AU131391 AU124704 BM016492 BU741449 AU125580 
    BU182370 AU124819 BP344015 AU125596 BI836448 AI634417 AI341124 BC000656 
    AK056208 BG388116 CF145828 BC065257 BM845017 BI910976 BG058558 BQ278388 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NOP2 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^
    SP1:                                -     -           -                             -                                   -                                       
    SP2:                                -     -           -                             -     -                       -     -                                       
    SP3:                                -     -           -                             -                             -     -                                       
    SP4:                                                  -                             -                             -     -                                       
    SP5:                                      -           -                             -     -                       -     -                                       

    ExUns: 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
    SP1:                                                                    -                           
    SP2:                                                                    -                           
    SP3:                                                                    -                           
    SP4:                                                                    -                           
    SP5:                                                                                                


    ECgene alternative splicing isoforms for NOP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTTAATA
    NOP2 Expression
    About this image


    NOP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Liver Lobule
    NOP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534334
        Custom PCR Arrays for NOP2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NOP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nop21 , 5 NOP2 nucleolar protein homolog (yeast)5
    NOP2 nucleolar protein1
    81.24(n)1
    78.53(a)1
      6 (59.32 cM)5
    1101091  NM_138747.21  NP_620086.21 
     1251318835 
    chicken
    (Gallus gallus)
    Aves NOP21 NOP2 nucleolar protein homolog (yeast) 65.98(n)
    70.03(a)
      418277  XM_416502.4  XP_416502.3 
    lizard
    (Anolis carolinensis)
    Reptilia NOP26
    NOP2 nucleolar protein
    63(a)
    1 ↔ 1
    GL343381.1(707783-731960)
    zebrafish
    (Danio rerio)
    Actinopterygii nop21 NOP2 nucleolar protein homolog (yeast) 62.01(n)
    64.57(a)
      321130  XM_005157940.1  XP_005157997.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85456
    --
    41(a)
    1 ↔ 1
    2R(8356145-8359227)
    worm
    (Caenorhabditis elegans)
    Secernentea nol-16
    Protein NOL-1 (nol-1) mRNA, complete cds
    43(a)
    1 ↔ 1
    II(471243-475940) WBGene00021073
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOP2(YNL061W)4 Probable RNA m(5)C methyltransferase, essential for more   --   14(510540-512396) 855664  NP_014338.1 


    ENSEMBL Gene Tree for NOP2 (if available)
    TreeFam Gene Tree for NOP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOP2 gene
    NSUN62  NSUN32  ENSG000002717862  NSUN42  

    Find genes that share paralogs with NOP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOP2 (see all 308)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857626811,2
    --6667374(+) AGCTGC/TGCCCT 5 -- int10--------
    rs676216791,2
    C,F--6667422(+) GGTGAT/ATCTCA 5 -- int16Minor allele frequency- A:0.33WA CSA NA 245
    rs118340741,2
    C,F,H--6667564(+) ctccgG/Aacaat 5 -- int12Minor allele frequency- A:0.17WA EA 238
    rs1384081541,2
    --6667581(+) CGTGCA/GCCACC 5 -- int10--------
    rs1493147601,2
    C--6667700(+) TGCTGA/GGGTTA 5 -- int10--------
    rs1915085461,2
    --6667712(+) AGGCGC/TGAGCC 5 -- int10--------
    rs1446315081,2
    --6668024(+) CCACAC/TCTGGC 5 -- int10--------
    rs1152305201,2
    C,F--6668065(+) TTCCAT/CGTGAA 5 -- int11Minor allele frequency- C:0.03WA 118
    rs746710641,2
    F--6668089(+) CGGGAT/CAATTA 5 -- int11Minor allele frequency- C:0.08WA 118
    rs1811267421,2
    --6668159(+) TTGCTC/TGTTGC 5 -- int10--------

    HapMap Linkage Disequilibrium report for NOP2 (6666029 - 6677857 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NOP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509452CNV Insertion20534489
    nsv898634CNV Loss21882294
    nsv826210CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOP2
    DNA2.0 Custom Variant and Variant Library Synthesis for NOP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164031    OMIM disorders: --


    Find genes that share disorders with NOP2           About GenesLikeMe

    8 Novoseek inferred disease relationships for NOP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma lung 38.1 6 11583194 (4), 10561346 (2)
    cancer 11.3 13 11004698 (4), 1728415 (2), 9514935 (2), 2256932 (1) (see all 7)
    tumors 10.7 25 10561346 (3), 9785132 (3), 9013835 (3), 11583194 (2) (see all 9)
    carcinoma 8.61 11 9013835 (5), 7511264 (1), 10365117 (1)
    carcinoma squamous cell 0 4 9815576 (2), 10365117 (1)
    cancer lung 0 10 9815576 (4), 11583194 (1)
    adenocarcinoma 0 2 10561346 (1), 9815576 (1)
    prostate cancer 0 1 9615190 (1)


    Export disorders for NOP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOP2 gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with NOP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation. (PubMed id 1394192)1, 2, 9 Valdez B.C.... Busch H. (Cancer Res. 1992)
    2. Genomic structure of the human proliferating cell nucleolar protein p120. (PubMed id 2372471)1, 2, 9 Larson R.G....Busch H. (Cancer Commun. 1990)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    7. The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120. (PubMed id 9654073)1, 2 Ren Y.... Busch H. (Eur. J. Biochem. 1998)
    8. Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids. (PubMed id 8088812)1, 3 Baens M....Marynen P. (Genomics 1994)
    9. Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120. (PubMed id 2576976)1, 2 Fonagy A.... Busch H. (Cancer Commun. 1989)
    10. Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23. (PubMed id 8089149)1, 9 Valdez B.C....Busch H. (J. Biol. Chem. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4839 HGNC: 7867 AceView: HOM-TES-103 Ensembl:ENSG00000111641 euGenes: HUgn4839
    ECgene: NOP2 H-InvDB: NOP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NOP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOP2 gene:
    Search GeneIP for patents involving NOP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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