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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOP2 Gene

protein-coding   GIFtS: 52
GCID: GC12M006666

NOP2 nucleolar protein

(Previous names: nucleolar protein 1 (120kD), nucleolar protein 1, 120kDa,...)
(Previous symbol: NOL1)
 Explore 14 diseases affiliated with
NOP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NOP2    

Aliases
for NOP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NOP2 Nucleolar Protein1 2     NOP2 Nucleolar Protein Homolog (Yeast)1
NOL11 2 3 5     Nucleolar Protein 1 (120kD)1
NOP1201 2     Nucleolar Protein 2 Homolog (Yeast)1
NSUN11 2     NOL1/NOP2/Sun Domain Family, Member 12
Nucleolar Protein 1, 120kDa1 2     NOP2 Nucleolar Protein Homolog2
P1201     Putative Ribosomal RNA Methyltransferase NOP22
Nucleolar Protein 2 Homolog2 3     EC 2.1.1.-3
Proliferating-Cell Nucleolar Antigen P1202 3     Nucleolar Protein 13
Proliferation-Associated Nucleolar Protein P1202 3     EC 2.1.18

External Ids:    HGNC: 78671   Entrez Gene: 48392   Ensembl: ENSG000001116417   OMIM: 1640315   UniProtKB: P460873   

Export aliases for NOP2 gene to outside databases

Previous GC identifers: GC12M006537 GC12M006525


Summaries
for NOP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NOP2_HUMAN, P46087
Function: May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated
with the cell proliferation. May act as ribosomal RNA methyltransferase

Gene Wiki entry for NOP2 (NOL1)


Genomic Views
for NOP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOP2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Elk-1   SREBP-1c   E2F-2   SREBP-1b   SREBP-1a   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NOP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

NOP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006666:  view genomic region     (about GC identifiers)

Start:
 6,666,029 bp from pter      End:
 6,677,857 bp from pter
Size:
 11,829 bases      Orientation:
 minus strand

Proteins
for NOP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NOP2_HUMAN, P46087 (See protein sequence)
Recommended Name: Putative ribosomal RNA methyltransferase NOP2  
Size: 812 amino acids; 89302 Da
Subunit: Interaction with MCRS1
Subcellular location: Nucleus, nucleolus
Developmental stage: Expressed in G1 and peaks during the early S phase of the cell cycle
Sequence caution: Sequence=AAA36398.1; Type=Frameshift; Positions=780; Sequence=CAA39119.1; Type=Frameshift;
Positions=780;
Secondary accessions: A1A4Z3 B3KPD6 Q05BA7 Q0P5S5 Q3KQS4 Q58F30
Alternative splicing: 4 isoforms:  P46087-1   P46087-2   P46087-3   P46087-4   

Explore the universe of human proteins at neXtProt for NOP2: NX_P46087

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46087

    • 3 DME Specific Peptides for NOP2 (P46087)
     LLDAPCS  CCAPGGKT  GGFDRVLLD 

    NOP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001028886.1  NP_001245237.1  NP_001245238.1  NP_001245239.1  NP_006161.2  

    ENSEMBL proteins: 
     ENSP00000444437   ENSP00000371858   ENSP00000439422   ENSP00000382392   ENSP00000313272  
     ENSP00000443150   ENSP00000440754   ENSP00000443035   ENSP00000442895   ENSP00000443585  
     ENSP00000441923   ENSP00000442742   ENSP00000445402  

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    OriGene Protein Over-expression Lysate (see all 3): NOP2
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    Novus Biologicals NOP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NOP2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--


    NOP2 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for NOP2

    Assay Products for NOP2: 
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    Uscn ELISAs and CLIAs for NOP2

    Protein Domains /
    Families
    for NOP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NOP2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011023 Nop2p
     IPR023267 RCMT
     IPR001678 Fmu/NOL1/Nop2p
     IPR018314 Fmu/NOL1/Nop2p_CS
     IPR023273 RCMT_NOP2

    Graphical View of Domain Structure for InterPro Entry P46087

    ProtoNet protein and cluster: P46087

    4 Blocks protein families:
    IPB001678 Bacterial Sun/eukaryotic nucleolar Nop1/Nop2
    IPB006174 16S rRNA m5C967 methyltransferase
    IPB011023 Nop2p
    IPB012586 P120R


    UniProtKB/Swiss-Prot: NOP2_HUMAN, P46087
    Similarity: Belongs to the methyltransferase superfamily. RsmB/NOP family


    Function
    for NOP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NOP2_HUMAN, P46087
    Function: May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated
    with the cell proliferation. May act as ribosomal RNA methyltransferase

    Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12

    miRNA
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    hsa-miR-513a-3p hsa-miR-223*
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for NOP2

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI12080348
    GO:0008168methyltransferase activity ----
    GO:0008757S-adenosylmethionine-dependent methyltransferase activity IEA--


    NOP2 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for NOP2:
     Decreased TP53 protein express  Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content 


    Pathways & Interactions
    for NOP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/110 Interacting proteins for NOP2 (P460872, 3 ENSP000003823924) via UniProtKB, MINT, STRING, and/or I2D (see all 110)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K1Q132332, 3MINT-48339 I2D: score=2 
    TOP1P113873, ENSP000003545224I2D: score=3 STRING: ENSP00000354522
    FBLP220873, ENSP000002218014I2D: score=1 STRING: ENSP00000221801
    MYBBP1AQ9BQG03, ENSP000003709684I2D: score=1 STRING: ENSP00000370968
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--
    GO:0008284positive regulation of cell proliferation TAS1394192


    NOP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NOP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NOP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOP2
    5 Novoseek chemical compound relationships for NOP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-adenosylmethionine 33.6 1 14656444 (1)
    paraffin 31.7 4 7511264 (2), 9413739 (1), 9615190 (1)
    actinomycin d 29 4 7650069 (1), 9514935 (1)
    thymidine 8.24 1 9815576 (1)
    tyrosine 0.436 3 2256932 (1), 8663278 (1), 9147580 (1)

    Search CenterWatch for drugs/clinical trials and news about NOP2 

    Transcripts
    for NOP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NOP2 gene (5 alternative transcripts): 
    NM_001033714.2  NM_001258308.1  NM_001258309.1  NM_001258310.1  NM_006170.3  

    Unigene Cluster for NOP2:

    NOP2 nucleolar protein
    Hs.534334  [show with all ESTs]
    Unigene Representative Sequence: NM_001258310
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000537442(uc021qty.1) ENST00000382421(uc021qtz.1) ENST00000545200(uc009zeq.2)
    ENST00000399466(uc021qtw.1) ENST00000322166(uc021qua.1) ENST00000541778(uc021qtx.1)
    ENST00000542015 ENST00000544630 ENST00000536506 ENST00000537708 ENST00000542919
    ENST00000542944 ENST00000542867 ENST00000400580 ENST00000536124 ENST00000538420
    ENST00000545492 ENST00000545915

    miRNA
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    hsa-miR-513a-3p hsa-miR-223*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK056208.1 AK129852.1 AK307582.1 BC000656.2 BC065257.1 BC082985.1 BC106072.1 BC128183.1 
    BC128184.1 M32110.1 X55504.1 

    16 DOTS entries:

    DT.415869  DT.97818161  DT.75190191  DT.100818843  DT.100818837  DT.100717250  DT.95133019  DT.92444365 
    DT.95133049  DT.121171240  DT.100818836  DT.121171232  DT.95133048  DT.100818835  DT.100818841  DT.75194478 

    24/251 AceView cDNA sequences (see all 251):

    BM016492 BG058558 AK129852 CD367092 CF146219 CD368633 AU121037 BG120140 
    BU157124 BF149320 BP344015 AW006297 AU130311 BU178189 CB130152 BE349528 
    AI825663 AW590125 BC000656 BU170313 BU741449 AU124819 AK056208 AI634417 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NOP2 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^
    SP1:                                -     -           -                             -                                   -                                       
    SP2:                                -     -           -                             -     -                       -     -                                       
    SP3:                                -     -           -                             -                             -     -                                       
    SP4:                                                  -                             -                             -     -                                       
    SP5:                                      -           -                             -     -                       -     -                                       

    ExUns: 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
    SP1:                                                                    -                           
    SP2:                                                                    -                           
    SP3:                                                                    -                           
    SP4:                                                                    -                           
    SP5:                                                                                                


    ECgene alternative splicing isoforms for NOP2

    Expression
    for NOP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATTTAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NOP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NOP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOP2

    SOURCE GeneReport for Unigene cluster: Hs.534334
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    In Situ
    Assay Products:     
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    Orthologs
    for NOP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOP2 gene from 8/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NOP21 NOP2 nucleolar protein homolog (yeast) 65.42(n)
    68.13(a)    		   418277  XM_416502.3  XP_416502.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NOP26
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343381.1(713588-731761)
    zebrafish
    (Danio rerio)    		 Actinopterygii nop21 NOP2 nucleolar protein homolog (yeast) 59.36(n)
    61.26(a)    		   321130  XM_001922319.3  XP_001922354.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG85451 CG8545 54.82(n)
    50.34(a)    		   36365  NM_136942.2  NP_610786.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea nol-11 Protein NOL-1 51.9(n)
    48.56(a)    		   173437  NM_061341.4  NP_493742.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes NOP2(YNL061W)4
    NOP21    		 Probable RNA m(5)C methyltransferase, essential for more4
    Nop2p1    		 55.86(n)1
    54.37(a)1    		   14(510540-512396)4
    8556641, 4  NP_014338.31  NP_014338.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons OLI21 S-adenosyl-L-methionine-dependent methyltransferase-like more 54.76(n)
    52.55(a)    		   835690  NM_180596.1  NP_850927.1 
    rice
    (Oryza sativa)    		 Liliopsida Os09g05513001 hypothetical protein 52.9(n)
    48.46(a)    		   4347787  NM_001070402.1  NP_001063867.1 


    ENSEMBL Gene Tree for NOP2 (if available)
    TreeFam Gene Tree for NOP2 (if available) 

    Paralogs
    for NOP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOP2 gene
    NSUN62  NSUN32  NSUN42  

    NOP2 for paralogs           About GeneDecksing



    Genomic Variants
    for NOP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/241 NCBI SNPs in NOP2 are shown (see all 241)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1819928691,2
    		--6665592(+) TCAGCC/TTCCCA 9 -- int1 us2k10--------
    rs1425430191,2
    		--6665756(+) CGCCTG/TGGCCT 9 -- us2k1 int10--------
    rs118333191,2
    		C,H,--6665775(+) gtgctA/Gggatt 9 -- us2k1 int11Minor allele frequency- G:0.00NA 2
    rs1846260291,2
    		--6665848(+) TTCAAC/TCACCC 9 -- us2k1 int10--------
    rs25346991,2
    		H--6666317(+) CTCTGG/CCAACT 13 /P /A us2k1 mis1 ut31 ese34Minor allele frequency- C:0.00NS EA 386
    rs25347001,2
    		C,H--6666318(+) TCTGGC/GAACTG 13 F L mis1 ut31 us2k16Minor allele frequency- G:0.00NS EA NA 422
    rs1893657081,2
    		--6666381(+) TTCAGA/GGTGGC 13 T us2k1 syn1 ut310--------
    rs1380025131,2
    		--6666388(+) TGGCCC/TGAGTC 13 Q R mis1 ut31 us2k10--------
    rs782867911,2
    		C,--6666409(+) ATAACA/CCAGCC 13 G V us2k1 mis1 ut310--------
    rs2016067131,2
    		--6666435(+) GTGCCC/GTTGGG 13 N K mis1 us2k1 ut310--------

    HapMap Linkage Disequilibrium report for NOP2 (6666029 - 6677857 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NOP2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOP2
    DNA2.0 Custom Variant and Variant Library Synthesis for NOP2

    Disorders / Diseases
    for NOP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NOP2 for disorders           About GeneDecksing

    OMIM gene information: 164031    OMIM disorders: --

    14 diseases for NOP2:    About MalaCards
    cri-du-chat syndrome    systemic lupus erythematosus    lupus erythematosus    adenocarcinoma
    endometrial carcinoma    prostate cancer    acute leukemia    lung adenocarcinoma
    prostate adenocarcinoma    prostatitis    lung cancer    carcinoma
    leukemia    malaria

    8 Novoseek disease relationships for NOP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma lung 38.1 6 11583194 (4), 10561346 (2)
    cancer 11.3 13 11004698 (4), 1728415 (2), 9514935 (2), 2256932 (1) (see all 7)
    tumors 10.7 25 10561346 (3), 9785132 (3), 9013835 (3), 11583194 (2) (see all 9)
    carcinoma 8.61 11 9013835 (5), 7511264 (1), 10365117 (1)
    carcinoma squamous cell 0 4 9815576 (2), 10365117 (1)
    cancer lung 0 10 9815576 (4), 11583194 (1)
    adenocarcinoma 0 2 10561346 (1), 9815576 (1)
    prostate cancer 0 1 9615190 (1)


    Export disorders for NOP2 gene to outside databases

    Publications
    for NOP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOP2 gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with NOP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation. (PubMed id 1394192)1, 2, 9 Valdez B.C.... Busch H. (1992)
    2. Genomic structure of the human proliferating cell nucleolar protein p120. (PubMed id 2372471)1, 2, 9 Larson R.G....Busch H. (1990)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    7. The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120. (PubMed id 9654073)1, 2 Ren Y.... Busch H. (1998)
    8. Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids. (PubMed id 8088812)1, 3 Baens M....Marynen P. (1994)
    9. Cloning of the cDNA and sequence of the human proliferating-cell nucleolar protein P120. (PubMed id 2576976)1, 2 Fonagy A.... Busch H. (1989)
    10. Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23. (PubMed id 8089149)1, 9 Valdez B.C....Busch H. (1994)

    External Searches for NOP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NOP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4839 HGNC: 7867 AceView: HOM-TES-103 Ensembl:ENSG00000111641 euGenes: HUgn4839
    ECgene: NOP2 H-InvDB: NOP2

    Other Databases showing NOP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NOP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NOP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NOP2 gene:
    Search GeneIP for patents involving NOP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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