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Aliases for NOP2 Gene

Aliases for NOP2 Gene

  • NOP2 Nucleolar Protein 2 3
  • Proliferation-Associated Nucleolar Protein P120 3 4
  • Proliferating-Cell Nucleolar Antigen P120 3 4
  • Nucleolar Protein 1, 120kDa 2 3
  • Nucleolar Protein 2 Homolog 3 4
  • NSUN1 3 4
  • NOL1 3 4
  • Putative Ribosomal RNA Methyltransferase NOP2 3
  • NOP2 Nucleolar Protein Homolog (Yeast) 2
  • NOL1/NOP2/Sun Domain Family, Member 1 3
  • Nucleolar Protein 2 Homolog (Yeast) 2
  • NOP2 Nucleolar Protein Homolog 3
  • Nucleolar Protein 1 (120kD) 2
  • NOP2/Sun Domain Family 2
  • Nucleolar Protein 1 4
  • EC 2.1.1.- 4
  • Member 1 2
  • EC 2.1.1 63
  • NOP120 3
  • P120 3

External Ids for NOP2 Gene

Previous HGNC Symbols for NOP2 Gene

  • NOL1

Previous GeneCards Identifiers for NOP2 Gene

  • GC12M006537
  • GC12M006666
  • GC12M006525

Summaries for NOP2 Gene

GeneCards Summary for NOP2 Gene

NOP2 (NOP2 Nucleolar Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and methyltransferase activity. An important paralog of this gene is NSUN3.

UniProtKB/Swiss-Prot for NOP2 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.

Gene Wiki entry for NOP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP2 Gene

Genomics for NOP2 Gene

Regulatory Elements for NOP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NOP2 Gene

Chromosome:
12
Start:
6,556,863 bp from pter
End:
6,568,691 bp from pter
Size:
11,829 bases
Orientation:
Minus strand

Genomic View for NOP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP2 Gene

Proteins for NOP2 Gene

  • Protein details for NOP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46087-NOP2_HUMAN
    Recommended name:
    Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
    Protein Accession:
    P46087
    Secondary Accessions:
    • A1A4Z3
    • B3KPD6
    • Q05BA7
    • Q0P5S5
    • Q3KQS4
    • Q58F30

    Protein attributes for NOP2 Gene

    Size:
    812 amino acids
    Molecular mass:
    89302 Da
    Quaternary structure:
    • Interaction with MCRS1 (PubMed:9654073). Interacts with WDR46 (PubMed:23848194).
    SequenceCaution:
    • Sequence=AAA36398.1; Type=Frameshift; Positions=780; Evidence={ECO:0000305}; Sequence=CAA39119.1; Type=Frameshift; Positions=780; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOP2 Gene

Proteomics data for NOP2 Gene at MOPED

Selected DME Specific Peptides for NOP2 Gene

Post-translational modifications for NOP2 Gene

Domains & Families for NOP2 Gene

Gene Families for NOP2 Gene

Suggested Antigen Peptide Sequences for NOP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46087

UniProtKB/Swiss-Prot:

NOP2_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
genes like me logo Genes that share domains with NOP2: view

Function for NOP2 Gene

Molecular function for NOP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + cytosine(4447) in 28S rRNA = S-adenosyl-L-homocysteine + C(5)-methylcytosine(4447) in 28S rRNA
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.

Enzyme Numbers (IUBMB) for NOP2 Gene

Gene Ontology (GO) - Molecular Function for NOP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 12080348
GO:0008168 methyltransferase activity --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOP2: view
genes like me logo Genes that share phenotypes with NOP2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOP2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NOP2 Gene

Localization for NOP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOP2 Gene COMPARTMENTS Subcellular localization image for NOP2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NOP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 16791210
genes like me logo Genes that share ontologies with NOP2: view

Pathways & Interactions for NOP2 Gene

SuperPathways for NOP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
GO:0008284 positive regulation of cell proliferation TAS 1394192
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with NOP2: view

No data available for Pathways by source and SIGNOR curated interactions for NOP2 Gene

Drugs & Compounds for NOP2 Gene

(3) Drugs for NOP2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
thymidine Experimental Pharma 0
tyrosine Nutra 547

(2) Additional Compounds for NOP2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Actinomycin D
Paraffin
genes like me logo Genes that share compounds with NOP2: view

Transcripts for NOP2 Gene

Unigene Clusters for NOP2 Gene

NOP2 nucleolar protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6:
SP7: - - - - - - -
SP8: - - -
SP9:
SP10: - - -
SP11: - -
SP12: - - - - - - - - - - - - - - - - - -
SP13: - -
SP14:
SP15:
SP16: - -

ExUns: 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - - - - -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NOP2 Gene

GeneLoc Exon Structure for
NOP2
ECgene alternative splicing isoforms for
NOP2

Expression for NOP2 Gene

mRNA expression in normal human tissues for NOP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOP2 Gene

This gene is overexpressed in Lung (32.3) and CD8 Tcells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOP2 Gene



SOURCE GeneReport for Unigene cluster for NOP2 Gene Hs.534334

genes like me logo Genes that share expression patterns with NOP2: view

Protein tissue co-expression partners for NOP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOP2 Gene

Orthologs for NOP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOP2 35
  • 84.72 (n)
  • 84.1 (a)
NOP2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOP2 35
  • 86.02 (n)
  • 83.62 (a)
NOP2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nop2 35
  • 81.24 (n)
  • 78.53 (a)
Nop2 16
Nop2 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOP2 35
  • 99.43 (n)
  • 99.14 (a)
NOP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nop2 35
  • 81.7 (n)
  • 80.13 (a)
oppossum
(Monodelphis domestica)
Mammalia NOP2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves NOP2 35
  • 65.98 (n)
  • 70.03 (a)
NOP2 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOP2 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nop2 35
  • 62.01 (n)
  • 64.57 (a)
nop2 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8545 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nol-1 36
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP2 36
  • 47 (a)
OneToMany
NOP2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
CSA.8854 36
  • 49 (a)
OneToMany
Species with no ortholog for NOP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NOP2 Gene

ENSEMBL:
Gene Tree for NOP2 (if available)
TreeFam:
Gene Tree for NOP2 (if available)

Paralogs for NOP2 Gene

Paralogs for NOP2 Gene

genes like me logo Genes that share paralogs with NOP2: view

Variants for NOP2 Gene

Sequence variations from dbSNP and Humsavar for NOP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1540259 -- 6,560,921(-) GACTC(A/G)GACTG intron-variant
rs1540260 -- 6,560,918(-) CTCAG(A/G)CTGTG intron-variant
rs1558333 -- 6,565,889(+) CAGCC(G/T)TCTAG intron-variant
rs1609677 -- 6,560,919(-) ACTCA(A/G)ACTGT intron-variant
rs1978009 -- 6,565,636(-) ttggc(C/T)tggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOP2 Gene

Variant ID Type Subtype PubMed ID
nsv898634 CNV Loss 21882294
nsv826210 CNV Gain 20364138
nsv509452 CNV Insertion 20534489

Variation tolerance for NOP2 Gene

Residual Variation Intolerance Score: 72.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOP2 Gene

HapMap Linkage Disequilibrium report
NOP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP2 Gene

Disorders for NOP2 Gene

Relevant External Links for NOP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOP2
genes like me logo Genes that share disorders with NOP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP2 Gene

Publications for NOP2 Gene

  1. E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia. (PMID: 18185522) Zhong C.H. … Hunger S.P. (Leukemia 2008) 23 67
  2. The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate. (PMID: 14656444) Foster P.G. … Stroud R.M. (Structure 2003) 23 67
  3. Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. (PMID: 11935223) Eschrich D. … Entian K.-D. (Curr. Genet. 2002) 23 67
  4. Expression of nucleolar protein p120 predicts poor prognosis in patients with stage I lung adenocarcinoma. (PMID: 11583194) Saijo Y. … Nukiwa T. (Ann. Oncol. 2001) 23 67
  5. p120 expression provides a reliable indication of the rapidity of cell duplication in cancer cells independently of tumour origin. (PMID: 11004698) TrerA" D. … Derenzini M. (J. Pathol. 2000) 23 67

Products for NOP2 Gene

Sources for NOP2 Gene

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