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Aliases for NOP2 Gene

Aliases for NOP2 Gene

  • NOP2 Nucleolar Protein 2 3 5
  • Proliferation-Associated Nucleolar Protein P120 3 4
  • Proliferating-Cell Nucleolar Antigen P120 3 4
  • Nucleolar Protein 1, 120kDa 2 3
  • Nucleolar Protein 2 Homolog 3 4
  • NSUN1 3 4
  • NOL1 3 4
  • Putative Ribosomal RNA Methyltransferase NOP2 3
  • NOP2 Nucleolar Protein Homolog (Yeast) 2
  • NOL1/NOP2/Sun Domain Family, Member 1 3
  • Nucleolar Protein 2 Homolog (Yeast) 2
  • NOP2 Nucleolar Protein Homolog 3
  • Nucleolar Protein 1 (120kD) 2
  • NOP2/Sun Domain Family 2
  • Nucleolar Protein 1 4
  • EC 2.1.1.- 4
  • Member 1 2
  • EC 2.1.1 63
  • NOP120 3
  • P120 3

External Ids for NOP2 Gene

Previous HGNC Symbols for NOP2 Gene

  • NOL1

Previous GeneCards Identifiers for NOP2 Gene

  • GC12M006537
  • GC12M006666
  • GC12M006525

Summaries for NOP2 Gene

GeneCards Summary for NOP2 Gene

NOP2 (NOP2 Nucleolar Protein) is a Protein Coding gene. Diseases associated with NOP2 include Kabuki Syndrome 1. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding and methyltransferase activity. An important paralog of this gene is NSUN3.

UniProtKB/Swiss-Prot for NOP2 Gene

  • S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).

Gene Wiki entry for NOP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP2 Gene

Genomics for NOP2 Gene

Regulatory Elements for NOP2 Gene

Enhancers for NOP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOP2 on UCSC Golden Path with GeneCards custom track

Promoters for NOP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOP2 Gene

Chromosome:
12
Start:
6,556,863 bp from pter
End:
6,568,691 bp from pter
Size:
11,829 bases
Orientation:
Minus strand

Genomic View for NOP2 Gene

Genes around NOP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP2 Gene

Proteins for NOP2 Gene

  • Protein details for NOP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46087-NOP2_HUMAN
    Recommended name:
    Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase
    Protein Accession:
    P46087
    Secondary Accessions:
    • A1A4Z3
    • B3KPD6
    • Q05BA7
    • Q0P5S5
    • Q3KQS4
    • Q58F30

    Protein attributes for NOP2 Gene

    Size:
    812 amino acids
    Molecular mass:
    89302 Da
    Quaternary structure:
    • Interaction with MCRS1 (PubMed:9654073). Interacts with WDR46 (PubMed:23848194).
    SequenceCaution:
    • Sequence=AAA36398.1; Type=Frameshift; Positions=780; Evidence={ECO:0000305}; Sequence=CAA39119.1; Type=Frameshift; Positions=780; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOP2 Gene

Proteomics data for NOP2 Gene at MOPED

Selected DME Specific Peptides for NOP2 Gene

Post-translational modifications for NOP2 Gene

Domains & Families for NOP2 Gene

Gene Families for NOP2 Gene

Suggested Antigen Peptide Sequences for NOP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P46087

UniProtKB/Swiss-Prot:

NOP2_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
genes like me logo Genes that share domains with NOP2: view

Function for NOP2 Gene

Molecular function for NOP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + cytosine(4447) in 28S rRNA = S-adenosyl-L-homocysteine + C(5)-methylcytosine(4447) in 28S rRNA.
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).

Enzyme Numbers (IUBMB) for NOP2 Gene

Gene Ontology (GO) - Molecular Function for NOP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IEA --
genes like me logo Genes that share ontologies with NOP2: view
genes like me logo Genes that share phenotypes with NOP2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP2 Gene

Localization for NOP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOP2 Gene COMPARTMENTS Subcellular localization image for NOP2 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for NOP2 Gene

Pathways & Interactions for NOP2 Gene

genes like me logo Genes that share pathways with NOP2: view

Pathways by source for NOP2 Gene

Gene Ontology (GO) - Biological Process for NOP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation TAS 1394192
genes like me logo Genes that share ontologies with NOP2: view

No data available for SIGNOR curated interactions for NOP2 Gene

Drugs & Compounds for NOP2 Gene

(3) Drugs for NOP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for NOP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NOP2: view

Transcripts for NOP2 Gene

Unigene Clusters for NOP2 Gene

NOP2 nucleolar protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6:
SP7: - - - - - - -
SP8: - - -
SP9:
SP10: - - -
SP11: - -
SP12: - - - - - - - - - - - - - - - - - -
SP13: - -
SP14:
SP15:
SP16: - -

ExUns: 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - - - - -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NOP2 Gene

GeneLoc Exon Structure for
NOP2
ECgene alternative splicing isoforms for
NOP2

Expression for NOP2 Gene

mRNA expression in normal human tissues for NOP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOP2 Gene

This gene is overexpressed in Lung (32.3) and CD8 Tcells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOP2 Gene



SOURCE GeneReport for Unigene cluster for NOP2 Gene Hs.534334

genes like me logo Genes that share expression patterns with NOP2: view

Protein tissue co-expression partners for NOP2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOP2 Gene

Orthologs for NOP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOP2 35
  • 84.72 (n)
  • 84.1 (a)
NOP2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOP2 35
  • 86.02 (n)
  • 83.62 (a)
NOP2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nop2 35
  • 81.24 (n)
  • 78.53 (a)
Nop2 16
Nop2 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOP2 35
  • 99.43 (n)
  • 99.14 (a)
NOP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nop2 35
  • 81.7 (n)
  • 80.13 (a)
oppossum
(Monodelphis domestica)
Mammalia NOP2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves NOP2 35
  • 65.98 (n)
  • 70.03 (a)
NOP2 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOP2 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nop2 35
  • 62.01 (n)
  • 64.57 (a)
nop2 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8545 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nol-1 36
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP2 36
  • 47 (a)
OneToMany
NOP2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
CSA.8854 36
  • 49 (a)
OneToMany
Species with no ortholog for NOP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NOP2 Gene

ENSEMBL:
Gene Tree for NOP2 (if available)
TreeFam:
Gene Tree for NOP2 (if available)

Paralogs for NOP2 Gene

Paralogs for NOP2 Gene

genes like me logo Genes that share paralogs with NOP2: view

Variants for NOP2 Gene

Sequence variations from dbSNP and Humsavar for NOP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_030938 -
rs1978009 -- 6,565,636(-) ttggc(C/T)tggca intron-variant
rs7133649 -- 6,561,373(+) ctgcc(A/G)aggac intron-variant
rs12828873 -- 6,563,797(+) AGAGT(A/G)ATTCA intron-variant
rs12831800 -- 6,564,494(+) cgcgt(C/T)ttggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOP2 Gene

Variant ID Type Subtype PubMed ID
nsv898634 CNV Loss 21882294
nsv826210 CNV Gain 20364138
nsv509452 CNV Insertion 20534489

Variation tolerance for NOP2 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NOP2 Gene

Disorders for NOP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NOP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kabuki syndrome 1
  • kabuki syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NOP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOP2
genes like me logo Genes that share disorders with NOP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOP2 Gene

Publications for NOP2 Gene

  1. A region of antisense RNA from human p120 cDNA with high homology to mouse p120 cDNA inhibits NIH 3T3 proliferation. (PMID: 1394192) Valdez B.C. … Busch H. (Cancer Res. 1992) 3 4 23 67
  2. Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids. (PMID: 8088812) Baens M. … Marynen P. (Genomics 1994) 2 3
  3. Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23. (PMID: 8089149) Valdez B.C. … Busch H. (J. Biol. Chem. 1994) 3 23
  4. Genomic structure of the human proliferating cell nucleolar protein p120. (PMID: 2372471) Larson R.G. … Busch H. (Cancer Commun. 1990) 3 23
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3

Products for NOP2 Gene

Sources for NOP2 Gene

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