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Aliases for NOP16 Gene

Aliases for NOP16 Gene

  • NOP16 Nucleolar Protein 2 3 5
  • HBV Pre-S2 Trans-Regulated Protein 3 2 3 4
  • Hypothetical Protein HSPC111 2 3
  • NOP16 Nucleolar Protein Homolog (Yeast) 2
  • Nucleolar Protein 16 Homolog (Yeast) 2
  • NOP16 Nucleolar Protein Homolog 3
  • Nucleolar Protein 16 Homolog 3
  • HSPC111 3
  • HSPC185 3

External Ids for NOP16 Gene

Previous GeneCards Identifiers for NOP16 Gene

  • GC05M175744
  • GC05M175810
  • GC05M170735

Summaries for NOP16 Gene

Entrez Gene Summary for NOP16 Gene

  • This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for NOP16 Gene

NOP16 (NOP16 Nucleolar Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP16 Gene

Genomics for NOP16 Gene

Regulatory Elements for NOP16 Gene

Enhancers for NOP16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOP16 on UCSC Golden Path with GeneCards custom track

Promoters for NOP16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOP16 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOP16 Gene

Chromosome:
5
Start:
176,383,937 bp from pter
End:
176,388,975 bp from pter
Size:
5,039 bases
Orientation:
Minus strand

Genomic View for NOP16 Gene

Genes around NOP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP16 Gene

Proteins for NOP16 Gene

  • Protein details for NOP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C1-NOP16_HUMAN
    Recommended name:
    Nucleolar protein 16
    Protein Accession:
    Q9Y3C1
    Secondary Accessions:
    • B4DV13
    • D6RGD3
    • Q05D05
    • Q6IAI6
    • Q6PIM0
    • Q8IXL5

    Protein attributes for NOP16 Gene

    Size:
    178 amino acids
    Molecular mass:
    21188 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH19331.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305}; Sequence=BAG62525.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305}; Sequence=EAW85085.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOP16 Gene

Proteomics data for NOP16 Gene at MOPED

Post-translational modifications for NOP16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOP16 Gene

Domains & Families for NOP16 Gene

Protein Domains for NOP16 Gene

Suggested Antigen Peptide Sequences for NOP16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3C1

UniProtKB/Swiss-Prot:

NOP16_HUMAN :
  • Belongs to the NOP16 family.
Family:
  • Belongs to the NOP16 family.
genes like me logo Genes that share domains with NOP16: view

No data available for Gene Families for NOP16 Gene

Function for NOP16 Gene

genes like me logo Genes that share phenotypes with NOP16: view

Animal Model Products

CRISPR Products

miRNA for NOP16 Gene

miRTarBase miRNAs that target NOP16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP16 Gene

Localization for NOP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP16 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOP16 Gene COMPARTMENTS Subcellular localization image for NOP16 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with NOP16: view

Pathways & Interactions for NOP16 Gene

SuperPathways for NOP16 Gene

No Data Available

Interacting Proteins for NOP16 Gene

Selected Interacting proteins: Q9Y3C1-NOP16_HUMAN for NOP16 Gene via I2D

Symbol External ID(s) Details
PRKAA1

Gene Ontology (GO) - Biological Process for NOP16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOP16 Gene

Drugs & Compounds for NOP16 Gene

No Compound Related Data Available

Transcripts for NOP16 Gene

Unigene Clusters for NOP16 Gene

NOP16 nucleolar protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOP16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - -
SP11:
SP12: - - - - - - - - -

Relevant External Links for NOP16 Gene

GeneLoc Exon Structure for
NOP16
ECgene alternative splicing isoforms for
NOP16

Expression for NOP16 Gene

mRNA expression in normal human tissues for NOP16 Gene

Protein differential expression in normal tissues from HIPED for NOP16 Gene

This gene is overexpressed in Lung (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NOP16 Gene



SOURCE GeneReport for Unigene cluster for NOP16 Gene Hs.696283

genes like me logo Genes that share expression patterns with NOP16: view

Protein tissue co-expression partners for NOP16 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOP16 Gene

Orthologs for NOP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOP16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOP16 35
  • 90.07 (n)
  • 93.82 (a)
NOP16 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOP16 35
  • 91.01 (n)
  • 95.51 (a)
NOP16 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nop16 35
  • 88.2 (n)
  • 91.01 (a)
Nop16 16
Nop16 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOP16 35
  • 99.44 (n)
  • 100 (a)
NOP16 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nop16 35
  • 88.39 (n)
  • 91.01 (a)
oppossum
(Monodelphis domestica)
Mammalia NOP16 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOP16 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOP16 35
  • 72.85 (n)
  • 74.16 (a)
NOP16 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOP16 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nop16 35
  • 61.22 (n)
  • 58.49 (a)
zebrafish
(Danio rerio)
Actinopterygii nop16 35
  • 56.83 (n)
  • 51.2 (a)
nop16 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK265.6 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4994 36
  • 30 (a)
OneToOne
Species with no ortholog for NOP16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOP16 Gene

ENSEMBL:
Gene Tree for NOP16 (if available)
TreeFam:
Gene Tree for NOP16 (if available)

Paralogs for NOP16 Gene

No data available for Paralogs for NOP16 Gene

Variants for NOP16 Gene

Variation tolerance for NOP16 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NOP16 Gene

Disorders for NOP16 Gene

Relevant External Links for NOP16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOP16

No disorders were found for NOP16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP16 Gene

Publications for NOP16 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome. (PMID: 18373870) Butt A.J. … Musgrove E.A. (Breast Cancer Res. 2008) 3 23
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NOP16 Gene

Sources for NOP16 Gene

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