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Aliases for NOP16 Gene

Aliases for NOP16 Gene

  • NOP16 Nucleolar Protein 2 3 5
  • HBV Pre-S2 Trans-Regulated Protein 3 2 3 4
  • Hypothetical Protein HSPC111 2 3
  • NOP16 Nucleolar Protein Homolog (Yeast) 2
  • Nucleolar Protein 16 Homolog (Yeast) 2
  • NOP16 Nucleolar Protein Homolog 3
  • Nucleolar Protein 16 Homolog 3
  • Nucleolar Protein 16 3
  • HSPC111 3
  • HSPC185 3

External Ids for NOP16 Gene

Previous GeneCards Identifiers for NOP16 Gene

  • GC05M175744
  • GC05M175810
  • GC05M170735

Summaries for NOP16 Gene

Entrez Gene Summary for NOP16 Gene

  • This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for NOP16 Gene

NOP16 (NOP16 Nucleolar Protein) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP16 Gene

Genomics for NOP16 Gene

Regulatory Elements for NOP16 Gene

Enhancers for NOP16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F176410 1.2 Ensembl ENCODE 13.2 -25.9 -25942 8.8 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 FOS KLF13 ENSG00000251414 FAF2 HIGD2A ARL10 NOP16 ENSG00000250909 MIR1271 KIAA1191 CDHR2 RN7SL684P
GH05F176580 0.6 ENCODE 11.7 -192.3 -192259 1.6 CDHR2 RN7SL684P CLTB HIGD2A NOP16 GPRIN1 PIR54069 ENSG00000207420
GH05F176481 0.4 ENCODE 11.4 -93.0 -92956 0.8 KLF1 SAP130 SIN3A BACH1 ZNF316 CTBP1 FOS NFE2 RCOR1 MAFK CLTB FAF2 HIGD2A NOP16 CDHR2 RN7SL684P MIR1271 ARL10 KIAA1191 PIR40188
GH05F176491 0.2 ENCODE 11.3 -102.2 -102220 0.2 BHLHE40 CLTB HIGD2A NOP16 CDHR2 RN7SL684P FAF2 ARL10 KIAA1191 MIR1271 PIR40188
GH05F176492 0.4 ENCODE 11.3 -103.4 -103435 1.3 ZNF623 CLTB HIGD2A NOP16 CDHR2 RN7SL684P FAF2 ARL10 MIR1271 KIAA1191 PIR40188
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NOP16 on UCSC Golden Path with GeneCards custom track

Promoters for NOP16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001297575 375 2401 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for NOP16 Gene

176,383,937 bp from pter
176,388,975 bp from pter
5,039 bases
Minus strand

Genomic View for NOP16 Gene

Genes around NOP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP16 Gene

Proteins for NOP16 Gene

  • Protein details for NOP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 16
    Protein Accession:
    Secondary Accessions:
    • B4DV13
    • D6RGD3
    • Q05D05
    • Q6IAI6
    • Q6PIM0
    • Q8IXL5

    Protein attributes for NOP16 Gene

    178 amino acids
    Molecular mass:
    21188 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH19331.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305}; Sequence=BAG62525.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305}; Sequence=EAW85085.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP16 Gene


neXtProt entry for NOP16 Gene

Post-translational modifications for NOP16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOP16 Gene

Domains & Families for NOP16 Gene

Protein Domains for NOP16 Gene

Suggested Antigen Peptide Sequences for NOP16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NOP16 family.
  • Belongs to the NOP16 family.
genes like me logo Genes that share domains with NOP16: view

No data available for Gene Families for NOP16 Gene

Function for NOP16 Gene

Gene Ontology (GO) - Molecular Function for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOP16: view
genes like me logo Genes that share phenotypes with NOP16: view

Animal Model Products

miRNA for NOP16 Gene

miRTarBase miRNAs that target NOP16

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP16 Gene

Localization for NOP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP16 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for NOP16 Gene COMPARTMENTS Subcellular localization image for NOP16 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with NOP16: view

Pathways & Interactions for NOP16 Gene

SuperPathways for NOP16 Gene

No Data Available

Interacting Proteins for NOP16 Gene

Selected Interacting proteins: Q9Y3C1-NOP16_HUMAN for NOP16 Gene via IID

Gene Ontology (GO) - Biological Process for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with NOP16: view

No data available for Pathways by source and SIGNOR curated interactions for NOP16 Gene

Transcripts for NOP16 Gene

Unigene Clusters for NOP16 Gene

NOP16 nucleolar protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - -
SP12: - - - - - - - - -

Relevant External Links for NOP16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOP16 Gene

mRNA expression in normal human tissues for NOP16 Gene

Protein differential expression in normal tissues from HIPED for NOP16 Gene

This gene is overexpressed in Lung (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOP16 Gene

Protein tissue co-expression partners for NOP16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOP16 Gene:


SOURCE GeneReport for Unigene cluster for NOP16 Gene:

genes like me logo Genes that share expression patterns with NOP16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOP16 Gene

Orthologs for NOP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOP16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOP16 34 35
  • 99.44 (n)
(Canis familiaris)
Mammalia NOP16 34 35
  • 91.01 (n)
(Bos Taurus)
Mammalia NOP16 34 35
  • 90.07 (n)
(Rattus norvegicus)
Mammalia Nop16 34
  • 88.39 (n)
(Mus musculus)
Mammalia Nop16 34 16 35
  • 88.2 (n)
(Ornithorhynchus anatinus)
Mammalia NOP16 35
  • 76 (a)
(Monodelphis domestica)
Mammalia NOP16 35
  • 63 (a)
(Gallus gallus)
Aves NOP16 34 35
  • 72.85 (n)
(Anolis carolinensis)
Reptilia NOP16 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nop16 34
  • 61.22 (n)
(Danio rerio)
Actinopterygii nop16 34 35
  • 56.83 (n)
(Caenorhabditis elegans)
Secernentea ZK265.6 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4994 35
  • 30 (a)
Species where no ortholog for NOP16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOP16 Gene

Gene Tree for NOP16 (if available)
Gene Tree for NOP16 (if available)

Paralogs for NOP16 Gene

No data available for Paralogs for NOP16 Gene

Variants for NOP16 Gene

Sequence variations from dbSNP and Humsavar for NOP16 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10042045 -- 176,385,214(+) TGAGC(C/T)GCTCA intron-variant
rs10603932 -- 176,387,609(+) GGCAG(-/GCAG)AGAAA intron-variant, upstream-variant-2KB
rs1060588 -- 176,388,873(-) ACTGG(A/G)GGCTT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs1065206 -- 176,384,232(-) GGAGT(A/G)ACTGG intron-variant, nc-transcript-variant, reference, synonymous-codon, missense, utr-variant-3-prime
rs1065212 -- 176,384,132(-) AGAGG(A/G)GCTGG intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NOP16 Gene

Variant ID Type Subtype PubMed ID
nsv1023853 CNV gain 25217958
nsv462549 CNV gain 19166990
nsv600341 CNV gain 21841781

Variation tolerance for NOP16 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOP16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP16 Gene

Disorders for NOP16 Gene

Relevant External Links for NOP16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOP16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP16 Gene

Publications for NOP16 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome. (PMID: 18373870) Butt A.J. … Musgrove E.A. (Breast Cancer Res. 2008) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64

Products for NOP16 Gene

Sources for NOP16 Gene

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