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Aliases for NOP16 Gene

Aliases for NOP16 Gene

  • NOP16 Nucleolar Protein 2 3 5
  • HBV Pre-S2 Trans-Regulated Protein 3 2 3 4
  • Hypothetical Protein HSPC111 2 3
  • NOP16 Nucleolar Protein Homolog (Yeast) 2
  • Nucleolar Protein 16 Homolog (Yeast) 2
  • NOP16 Nucleolar Protein Homolog 3
  • Nucleolar Protein 16 Homolog 3
  • Nucleolar Protein 16 3
  • HSPC111 3
  • HSPC185 3

External Ids for NOP16 Gene

Previous GeneCards Identifiers for NOP16 Gene

  • GC05M175744
  • GC05M175810
  • GC05M170735

Summaries for NOP16 Gene

Entrez Gene Summary for NOP16 Gene

  • This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for NOP16 Gene

NOP16 (NOP16 Nucleolar Protein) is a Protein Coding gene.

Additional gene information for NOP16 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP16 Gene

Genomics for NOP16 Gene

GeneHancer (GH) Regulatory Elements for NOP16 Gene

Promoters and enhancers for NOP16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I176386 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 556.6 +0.6 553 4.1 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 HIGD2A NOP16 FAF2 ENSG00000251414 ENSG00000250909 NSD1 RPL21P60 UIMC1 MXD3 ZNF346
GH05I176410 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 13.2 -25.9 -25941 8.8 PKNOX1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZNF207 ZNF143 FOS CLTB ENSG00000251414 FAF2 HIGD2A ARL10 NOP16 UIMC1 ENSG00000250909 MIR1271 KIAA1191
GH05I176481 Enhancer 0.7 ENCODE 11.4 -93.0 -92956 0.8 HDAC1 KLF1 SAP130 BACH1 ZNF316 NFE2 PRDM10 MAFK NFE2L2 ZNF639 CLTB FAF2 NOP16 HIGD2A CDHR2 RN7SL684P MIR1271 ARL10 KIAA1191 PIR40188
GH05I176491 Enhancer 0.4 ENCODE 11.3 -102.2 -102220 0.2 SP1 REST FOSL2 CLTB NOP16 HIGD2A CDHR2 RN7SL684P FAF2 ARL10 KIAA1191 MIR1271 PIR40188
GH05I176492 Enhancer 0.4 ENCODE 11.3 -103.4 -103435 1.3 NFIC ZNF623 CLTB NOP16 HIGD2A CDHR2 RN7SL684P FAF2 ARL10 MIR1271 KIAA1191 PIR40188
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NOP16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NOP16 gene promoter:

Genomic Locations for NOP16 Gene

Genomic Locations for NOP16 Gene
5,039 bases
Minus strand

Genomic View for NOP16 Gene

Genes around NOP16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP16 Gene

Proteins for NOP16 Gene

  • Protein details for NOP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 16
    Protein Accession:
    Secondary Accessions:
    • B4DV13
    • D6RGD3
    • Q05D05
    • Q6IAI6
    • Q6PIM0
    • Q8IXL5

    Protein attributes for NOP16 Gene

    178 amino acids
    Molecular mass:
    21188 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH19331.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305}; Sequence=BAG62525.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305}; Sequence=EAW85085.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP16 Gene


neXtProt entry for NOP16 Gene

Post-translational modifications for NOP16 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NOP16 Gene

Domains & Families for NOP16 Gene

Gene Families for NOP16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOP16 Gene

Suggested Antigen Peptide Sequences for NOP16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NOP16 family.
  • Belongs to the NOP16 family.
genes like me logo Genes that share domains with NOP16: view

Function for NOP16 Gene

Gene Ontology (GO) - Molecular Function for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with NOP16: view
genes like me logo Genes that share phenotypes with NOP16: view

miRNA for NOP16 Gene

miRTarBase miRNAs that target NOP16

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP16 Gene

Localization for NOP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP16 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOP16 gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with NOP16: view

Pathways & Interactions for NOP16 Gene

SuperPathways for NOP16 Gene

No Data Available

Interacting Proteins for NOP16 Gene

Selected Interacting proteins: Q9Y3C1-NOP16_HUMAN for NOP16 Gene via IID

Gene Ontology (GO) - Biological Process for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with NOP16: view

No data available for Pathways by source and SIGNOR curated interactions for NOP16 Gene

Drugs & Compounds for NOP16 Gene

No Compound Related Data Available

Transcripts for NOP16 Gene

Unigene Clusters for NOP16 Gene

NOP16 nucleolar protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - -
SP12: - - - - - - - - -

Relevant External Links for NOP16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOP16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOP16 Gene

Protein differential expression in normal tissues from HIPED for NOP16 Gene

This gene is overexpressed in Lung (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NOP16 Gene

Protein tissue co-expression partners for NOP16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOP16 Gene:


SOURCE GeneReport for Unigene cluster for NOP16 Gene:


Evidence on tissue expression from TISSUES for NOP16 Gene

  • Lung(4.4)
  • Intestine(4.3)
  • Blood(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with NOP16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOP16 Gene

Orthologs for NOP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOP16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOP16 34 33
  • 99.44 (n)
(Canis familiaris)
Mammalia NOP16 33 34
  • 91.01 (n)
(Bos Taurus)
Mammalia NOP16 33 34
  • 90.07 (n)
(Rattus norvegicus)
Mammalia Nop16 33
  • 88.39 (n)
(Mus musculus)
Mammalia Nop16 33 16 34
  • 88.2 (n)
(Ornithorhynchus anatinus)
Mammalia NOP16 34
  • 76 (a)
(Monodelphis domestica)
Mammalia NOP16 34
  • 63 (a)
(Gallus gallus)
Aves NOP16 34 33
  • 72.85 (n)
(Anolis carolinensis)
Reptilia NOP16 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nop16 33
  • 61.22 (n)
(Danio rerio)
Actinopterygii nop16 33 34
  • 56.83 (n)
(Caenorhabditis elegans)
Secernentea ZK265.6 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4994 34
  • 30 (a)
Species where no ortholog for NOP16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOP16 Gene

Gene Tree for NOP16 (if available)
Gene Tree for NOP16 (if available)

Paralogs for NOP16 Gene

No data available for Paralogs for NOP16 Gene

Variants for NOP16 Gene

Sequence variations from dbSNP and Humsavar for NOP16 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000108407 -- 176,384,619(-) T/G intron_variant
rs1000459344 -- 176,389,670(-) T/C upstream_transcript_variant
rs1001320589 -- 176,389,600(-) C/T upstream_transcript_variant
rs1001629098 -- 176,387,265(-) A/G intron_variant
rs1002462273 -- 176,386,761(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NOP16 Gene

Variant ID Type Subtype PubMed ID
nsv1023853 CNV gain 25217958
nsv462549 CNV gain 19166990
nsv600341 CNV gain 21841781

Variation tolerance for NOP16 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NOP16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP16 Gene

Disorders for NOP16 Gene

Additional Disease Information for NOP16

No disorders were found for NOP16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP16 Gene

Publications for NOP16 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  3. The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome. (PMID: 18373870) Butt AJ … Musgrove EA (Breast cancer research : BCR 2008) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 58

Products for NOP16 Gene

Sources for NOP16 Gene

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