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Aliases for NOP16 Gene

Aliases for NOP16 Gene

  • NOP16 Nucleolar Protein 2 3
  • HBV Pre-S2 Trans-Regulated Protein 3 2 3 4
  • Hypothetical Protein HSPC111 2 3
  • HSPC111 3 6
  • NOP16 Nucleolar Protein Homolog (Yeast) 2
  • Nucleolar Protein 16 Homolog (Yeast) 2
  • NOP16 Nucleolar Protein Homolog 3
  • Nucleolar Protein 16 Homolog 3
  • Nucleolar Protein 16 3
  • HSPC185 3
  • NOP15 6

External Ids for NOP16 Gene

Previous GeneCards Identifiers for NOP16 Gene

  • GC05M175744
  • GC05M175810
  • GC05M170735

Summaries for NOP16 Gene

Entrez Gene Summary for NOP16 Gene

  • NOP16 is transcriptionally regulated by c-Myc (MYC; MIM 190080), upregulated in breast cancer, and overexpression is associated with poor patient survival (Butt et al., 2008).[supplied by OMIM, Jun 2009]

GeneCards Summary for NOP16 Gene

NOP16 (NOP16 Nucleolar Protein) is a Protein Coding gene. Diseases associated with NOP16 include breast cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP16 Gene

Genomics for NOP16 Gene

Regulatory Elements for NOP16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NOP16 Gene

176,383,937 bp from pter
176,388,975 bp from pter
5,039 bases
Minus strand

Genomic View for NOP16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP16 Gene

Proteins for NOP16 Gene

  • Protein details for NOP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 16
    Protein Accession:
    Secondary Accessions:
    • B4DV13
    • D6RGD3
    • Q05D05
    • Q6IAI6
    • Q6PIM0
    • Q8IXL5

    Protein attributes for NOP16 Gene

    178 amino acids
    Molecular mass:
    21188 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH19331.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305}; Sequence=BAG62525.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305}; Sequence=EAW85085.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP16 Gene


neXtProt entry for NOP16 Gene

Proteomics data for NOP16 Gene at MOPED

Post-translational modifications for NOP16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOP16 Gene

Domains for NOP16 Gene

Protein Domains for NOP16 Gene

Suggested Antigen Peptide Sequences for NOP16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y3C1
  • Belongs to the NOP16 family.
genes like me logo Genes that share domains with NOP16: view

No data available for Gene Families for NOP16 Gene

Function for NOP16 Gene

Gene Ontology (GO) - Molecular Function for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOP16: view

Phenotypes for NOP16 Gene

GenomeRNAi human phenotypes for NOP16:
genes like me logo Genes that share phenotypes with NOP16: view

Animal Model Products

CRISPR Products

miRNA for NOP16 Gene

miRTarBase miRNAs that target NOP16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NOP16 Gene

Localization for NOP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP16 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for NOP16 Gene COMPARTMENTS Subcellular localization image for NOP16 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with NOP16: view

Pathways for NOP16 Gene

SuperPathways for NOP16 Gene

No Data Available

Interacting Proteins for NOP16 Gene

Selected Interacting proteins: Q9Y3C1-NOP16_HUMAN for NOP16 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NOP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with NOP16: view

No data available for Pathways by source for NOP16 Gene

Transcripts for NOP16 Gene

Unigene Clusters for NOP16 Gene

NOP16 nucleolar protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOP16

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - -
SP12: - - - - - - - - -

Relevant External Links for NOP16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOP16 Gene

mRNA expression in normal human tissues for NOP16 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NOP16 Gene

SOURCE GeneReport for Unigene cluster for NOP16 Gene Hs.696283

genes like me logo Genes that share expressions with NOP16: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOP16 Gene

Orthologs for NOP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOP16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOP16 35
  • 99.44 (n)
  • 100 (a)
NOP16 36
  • 99 (a)
(Bos Taurus)
Mammalia NOP16 35
  • 90.07 (n)
  • 93.82 (a)
NOP16 36
  • 74 (a)
(Canis familiaris)
Mammalia NOP16 35
  • 91.01 (n)
  • 95.51 (a)
NOP16 36
  • 78 (a)
(Mus musculus)
Mammalia Nop16 35
  • 88.2 (n)
  • 91.01 (a)
Nop16 16
Nop16 36
  • 72 (a)
(Monodelphis domestica)
Mammalia NOP16 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia NOP16 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Nop16 35
  • 88.39 (n)
  • 91.01 (a)
(Gallus gallus)
Aves NOP16 35
  • 72.85 (n)
  • 74.16 (a)
NOP16 36
  • 58 (a)
(Anolis carolinensis)
Reptilia NOP16 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nop16 35
  • 61.22 (n)
  • 58.49 (a)
(Danio rerio)
Actinopterygii nop16 35
  • 56.83 (n)
  • 51.2 (a)
nop16 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea ZK265.6 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4994 36
  • 30 (a)
Species with no ortholog for NOP16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOP16 Gene

Gene Tree for NOP16 (if available)
Gene Tree for NOP16 (if available)

Paralogs for NOP16 Gene

No data available for Paralogs for NOP16 Gene

Variants for NOP16 Gene

Sequence variations from dbSNP and Humsavar for NOP16 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs953251 -- 176,386,030(+) GGTAG(A/G)GGAAG intron-variant, utr-variant-3-prime
rs1065206 -- 176,384,232(-) GGAGT(A/G)ACTGG missense, reference, synonymous-codon, utr-variant-3-prime
rs1065212 -- 176,384,132(-) AGAGG(A/G)GCTGG reference, missense, utr-variant-3-prime
rs2241578 -- 176,383,711(+) GCAGG(A/C)CCCTT intron-variant
rs2335416 -- 176,386,401(+) TAGAG(G/T)ATTCC intron-variant, utr-variant-3-prime

Relevant External Links for NOP16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NOP16 Gene

Disorders for NOP16 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NOP16 Gene including...

Search for NOP16 Gene in MalaCards »
genes like me logo Genes that share disorders with NOP16: view

No data available for UniProtKB/Swiss-Prot for NOP16 Gene

Publications for NOP16 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome. (PMID: 18373870) Butt A.J. … Musgrove E.A. (Breast Cancer Res. 2008) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NOP16 Gene

Sources for NOP16 Gene

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