NOP16 Gene
protein-coding GIFtS: 44
GCID: GC05M175810
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NOP16 nucleolar protein(Previous names: nucleolar protein 16 homolog (yeast), NOP16 nucleolar protein...)
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Aliases
for NOP16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NOP16 Nucleolar Protein1 2 | | Nucleolar Protein 16 Homolog (Yeast)1 | | HSPC1111 2 5 | | Hypothetical Protein HSPC1112 | | HSPC1851 2 | | NOP16 Nucleolar Protein Homolog2 | | HBV Pre-S2 Trans-Regulated Protein 32 3 | | Nucleolar Protein 162 | | LOC514911 | | Nucleolar Protein 16 Homolog2 | | NOP16 Nucleolar Protein Homolog (Yeast)1 | | NOP155 |
Export aliases for NOP16 gene to outside databasesPrevious GC identifers: GC05M175744 GC05M170735 |
Summaries
for NOP16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NOP16:
NOP16 is transcriptionally regulated by c-Myc (MYC; MIM 190080), upregulated in breast cancer, and overexpression isassociated with poor patient survival (Butt et al., 2008).(supplied by OMIM, Jun 2009)
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Genomic Views
for NOP16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOP16 gene promoter:
AP-2rep Tal-1 CUTL1 E47 GATA-1 GATA-2 Egr-2 E2F-1 E2F COMP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOP16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOP16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.2 Ensembl cytogenetic band: 5q35.2 HGNC cytogenetic band: 5q35.2NOP16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M175810: view genomic region
(about GC identifiers)
Start:
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175,810,949 bp from pter |
End:
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175,815,976 bp from pter |
Size:
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5,028 bases |
Orientation:
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minus strand |
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Proteins
for NOP16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOP16_HUMAN, Q9Y3C1 (See
protein sequence)Recommended Name: Nucleolar protein 16 Size: 178 amino acids; 21188 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAH19331.1; Type=Frameshift; Positions=195; Sequence=BAG62525.1; Type=Frameshift;Positions=195; Sequence=EAW85085.1; Type=Frameshift; Positions=195;
Secondary accessions: B4DV13 D6RGD3 Q05D05 Q6IAI6 Q8IXL5Alternative splicing: 2 isoforms: Q9Y3C1-1 Q9Y3C1-2 (Ref.4 (BAG62525) sequence is in conflict in position: 171:C->F)Explore the universe of human proteins at neXtProt for NOP16: NX_Q9Y3C1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3C1
NOP16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001243468.1 NP_001243469.1 NP_057475.2
ENSEMBL proteins: ENSP00000421302 ENSP00000373810 ENSP00000426392 ENSP00000423835 ENSP00000427489
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NOP16 for ontologies About GeneDecksing
NOP16 Antibody Products:
Assay Products for NOP16: |
Protein
Domains /
Families
for NOP16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOP16 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y3C1ProtoNet protein and cluster: Q9Y3C1 1 Blocks protein family: IPB011986 Extradiol ring-cleavage dioxygenase LigAB
UniProtKB/Swiss-Prot: NOP16_HUMAN, Q9Y3C1Similarity: Belongs to the NOP16 family |
Function
for NOP16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOP16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOP16 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NOP16 (NM_016391) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOP16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOP16 |
1 GenomeRNAi human phenotype for NOP16:
|
Pathways & Interactions
for NOP16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOP16
1 Interacting protein for NOP16 (Q9Y3C13) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for NOP16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NOP16
Search CenterWatch for drugs/clinical trials and news about NOP16
|
Transcripts
for NOP16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOP16 gene (3 alternative transcripts): NM_001256539.1 NM_001256540.1 NM_016391.5 Unigene Cluster for NOP16: NOP16 nucleolar protein Hs.696283 [show with all ESTs]Unigene Representative Sequence: AF1518759 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000510123(uc003med.3) ENST00000389158(uc003mee.3 uc011dfl.2)
ENST00000507413 ENST00000502663 ENST00000503849 ENST00000504821 ENST00000509257
ENST00000502577 ENST00000510608(uc011dfm.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOP16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOP16 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NOP16 (NM_016391) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOP16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOP16 |
Additional cDNA sequence: AF151019.1 AF151875.1 AF161460.1 AK300883.1 AK303281.1 AY561704.1 BC019331.1 BC032424.2 BC040106.1 CR457169.1 19 DOTS entries: DT.120886677 DT.95183655 DT.100044326 DT.75168633 DT.92432837 DT.91872948 DT.120886702 DT.92422107 DT.120886690 DT.100825850 DT.120886652 DT.120886674 DT.100825848 DT.120886561 DT.97760027 DT.92009107 DT.102832980 DT.95134112 DT.95134118 24/312 AceView cDNA sequences (see all 312): AI272806 AY561704 CB050026 BX281362 BM756015 BQ220893 BM738729 BQ893043 AI424346 CR611555 BE797119 AI056707 CA488856 BG758618 BM128119 BI861405 BQ957599 BM464165 BQ683538 BM822858 BM801703 AI695472 BM459107 AA974363
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for NOP16 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
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| SP1: | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for NOP16
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Expression
for NOP16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOP16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATCAGAAG
About this image
See NOP16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOP16
SOURCE GeneReport for Unigene cluster: Hs.696283
SABiosciences Custom PCR Arrays for NOP16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOP16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOP16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOP16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOP16 |
Orthologs
for NOP16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for NOP16 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for NOP16 (if available)
TreeFam Gene Tree for NOP16 (if available) |
Paralogs
for NOP16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NOP16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NOP16 (175810949 - 175815976 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NOP16: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for NOP16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NOP16 for disorders About GeneDecksing
OMIM gene information: 612861
OMIM disorders: --
1  disease for NOP16: About MalaCardsbreast cancer
Export disorders for NOP16 gene to outside databases
|
Publications
for NOP16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOP16 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with NOP16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- The estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome. (PubMed id 18373870)1, 9 Butt A.J....Musgrove E.A. (2008)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for NOP16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NOP16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOP16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOP16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOP16 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NOP16 gene:
Search GeneIP for patents involving NOP16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOP16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NOP16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOP16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOP16 | | | OriGene Protein Over-expression Lysate for NOP16 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NOP16 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOP16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOP16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NOP16 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NOP16 | | OriGene Custom Protein Services for NOP16 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOP16 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOP16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOP16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOP16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOP16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOP16 |
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| | | | Search Tocris compounds for NOP16 |
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 | | | NOP16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for NOP16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOP16 |
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