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NOP14 Gene

protein-coding   GIFtS: 49
GCID: GC04M002939

NOP14 Nucleolar Protein

(Previous names: chromosome 4 open reading frame 9, nucleolar protein 14,...)
(Previous symbols: C4orf9, NOL14)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NOP14 Nucleolar Protein1 2     NOP14 Nucleolar Protein Homolog (Yeast)1
NOL141 2 3 5     Nucleolar Protein 14 Homolog (Yeast)1
C4orf91 2 3     UTP22
Nucleolar Protein 141 2     NOP14 Homolog2
Nucleolar Complex Protein 142 3     NOP14 Nucleolar Protein Homolog2
RES4252 5     Nucleolar Protein 14 Homolog2
Chromosome 4 Open Reading Frame 91     Probable Nucleolar Complex Protein 142
NOP14 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 168211   Entrez Gene: 86022   Ensembl: ENSG000000872697   OMIM: 6115265   UniProtKB: P783163   

Export aliases for NOP14 gene to outside databases

Previous GC identifer: GC04M002910


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOP14 Gene:
NOP14 plays a role in the processing of the pre-18S rRNA and small ribosomal subunit assembly (Liu and Thiele,
2001 (PubMed 11694595)).(supplied by OMIM, Jun 2009)

GeneCards Summary for NOP14 Gene:
NOP14 (NOP14 nucleolar protein) is a protein-coding gene. GO annotations related to this gene include snoRNA binding.

UniProtKB/Swiss-Prot: NOP14_HUMAN, P78316
Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S
pre-ribosomal subunit to the cytoplasm (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOP14 gene promoter:
         E2F-4   E2F-5   Pax-5   GCNF   E47   c-Rel   CP2   GCNF-1   Hand1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOP14 promoter sequence
   Search Chromatin IP Primers for NOP14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

NOP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOP14 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M002939:  view genomic region     (about GC identifiers)

Start:
2,939,660 bp from pter      End:
2,965,118 bp from pter
Size:
25,459 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NOP14_HUMAN, P78316 (See protein sequence)
Recommended Name: Nucleolar protein 14  
Size: 857 amino acids; 97668 Da
Subunit: Component of the ribosomal small subunit (SSU) processome (By similarity)
Sequence caution: Sequence=AAB97011.1; Type=Erroneous initiation;
Secondary accessions: D3DVR6 Q7LGI5 Q7Z6K0 Q8TBR6
Alternative splicing: 2 isoforms:  P78316-1   P78316-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOP14: NX_P78316

Explore proteomics data for NOP14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys834
  • Modification sites at PhosphoSitePlus

  • See NOP14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003694.1  
    ENSEMBL proteins: 
     ENSP00000405068   ENSP00000315674   ENSP00000427415   ENSP00000381146  

    NOP14 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007276 Nop14

    Graphical View of Domain Structure for InterPro Entry P78316

    ProtoNet protein and cluster: P78316

    UniProtKB/Swiss-Prot: NOP14_HUMAN, P78316
    Similarity: Belongs to the NOP14 family


    Find genes that share domains with NOP14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOP14_HUMAN, P78316
    Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S
    pre-ribosomal subunit to the cytoplasm (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030515snoRNA binding ISS--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NOP14           About GenesLikeMe


    Phenotypes:
         8 GenomeRNAi human phenotypes for NOP14:
     Decreased Hepatitis C virus re  Decreased viability of wild-ty  Increased S DNA content, incre  Increased gamma-H2AX phosphory 
     Nuclear 40S maturation defects  Nucleolar pre-40S maturation d  S arrest  Synthetic lethal with Ras 

    Animal Models:
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    miRNA
    Products:
        
    miRTarBase miRNAs that target NOP14:
    hsa-let-7b-5p (MIRT032426), hsa-mir-24-3p (MIRT030569), hsa-mir-16-5p (MIRT031738), hsa-mir-30a-5p (MIRT028573)

    Block miRNA regulation of human, mouse, rat NOP14 using miScript Target Protectors
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOP14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOP14_HUMAN, P78316: Nucleus, nucleolus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    nucleus4
    plasma membrane3
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus ISS--
    GO:0005739mitochondrion ISS--
    GO:003068690S preribosome ISS--
    GO:0030692Noc4p-Nop14p complex ISS--

    Find genes that share ontologies with NOP14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOP14
    Interactions:

        Search GeneGlobe Interaction Network for NOP14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOP14 (P783163 ENSP000003156744) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    PDCD11ENSP000003588124STRING: ENSP00000358812
    BYSLENSP000002303404STRING: ENSP00000230340
    NOC4LENSP000003288544STRING: ENSP00000328854
    NOL6ENSP000002979904STRING: ENSP00000297990
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS--
    GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS--
    GO:0000472endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS--
    GO:0000480endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS--
    GO:0006364rRNA processing ISS--

    Find genes that share ontologies with NOP14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOP14



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOP14 gene: 
    NM_003703.1  

    Unigene Cluster for NOP14:

    NOP14 nucleolar protein
    Hs.627133  [show with all ESTs]
    Unigene Representative Sequence: AK292939
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507120 ENST00000416614(uc010icp.2 uc003ggj.1 uc003ggl.3 uc010icq.1)
    ENST00000314262 ENST00000502735 ENST00000398071
    miRNA
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    GenScript: all cDNA clones in your preferred vector: NOP14 (NM_003703)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOP14
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NOP14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOP14
      QuantiTect SYBR Green Assays in human, mouse, rat NOP14
      QuantiFast Probe-based Assays in human, mouse, rat NOP14

    Additional mRNA sequence: 

    AB000467.1 AF040965.1 AK024755.1 AK025692.1 AK292939.1 BC009760.2 BC017358.1 BC026035.1 
    BC053635.1 L37199.1 

    18 DOTS entries:

    DT.100795025  DT.100765045  DT.95210850  DT.114803  DT.97771622  DT.100795021  DT.95171069  DT.97765729 
    DT.100861760  DT.100836939  DT.100795022  DT.449146  DT.92441183  DT.95148899  DT.100795024  DT.121237124 
    DT.97823770  DT.99955988 

    Selected AceView cDNA sequences (see all 162):

    BE397579 D44629 BQ688621 BF981255 AU142372 AK025692 R06835 BQ061722 
    AB000467 CR612484 BQ927529 AF040965 BU849920 BU146481 CR614906 BQ217992 
    BQ056037 AA503745 CF125677 BC009760 BC026035 BE543128 BQ948351 BX093602 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NOP14 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                      -     -     -     -   
    SP5:                                                                          -                                                                                 

    ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c
    SP1:                                -               
    SP2:        -     -     -     -                     
    SP3:                                                
    SP4:  -     -     -     -     -                     
    SP5:                                                


    ECgene alternative splicing isoforms for NOP14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOP14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGAATTT
    NOP14 Expression
    About this image


    NOP14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Lymph (Hematopoietic System)
    NOP14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOP14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.627133
        Custom PCR Arrays for NOP14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOP14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOP14 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nop141 , 5 NOP14 nucleolar protein homolog (yeast)5
    NOP14 nucleolar protein1
    81.93(n)1
    83.51(a)1
      5 (17.91 cM)5
    754161  NM_029278.21  NP_083554.21 
     346385325 
    chicken
    (Gallus gallus)
    Aves NOP141 NOP14 nucleolar protein homolog (yeast) 67.38(n)
    67.22(a)
      422880  XM_420824.4  XP_420824.2 
    lizard
    (Anolis carolinensis)
    Reptilia NOP146
    NOP14 nucleolar protein
    64(a)
    1 ↔ 1
    5(80187291-80217126)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256982 Xenopus laevis transcribed sequence with weak similarity more 78.06(n)    BU906315.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK028302.12   -- 72.64(n)   321133  CK028302.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)078821 lethal (3) 07882 46.03(n)
    35.64(a)
      46201  NM_143783.3  NP_652040.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G1A.46
    Protein Y48G1A.4 (Y48G1A.4) mRNA, complete cds
    29(a)
    1 ↔ 1
    I(323860-330990) WBGene00021660
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOP14(YDL148C)4 Nucleolar protein, forms a complex with Noc4p that more   --   4(190586-188154) 851407  NP_010133.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G690701 AT1G69070 43.9(n)
    32.8(a)
      843239  NM_105577.2  NP_177070.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g05982001 Os03g0598200 45.53(n)
    34.08(a)
      4333384  NM_001057144.1  NP_001050609.1 


    ENSEMBL Gene Tree for NOP14 (if available)
    TreeFam Gene Tree for NOP14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOP14 (see all 309)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834290091,2
    C--2953299(+) GAGAAG/TAGGAG 1 -- int10--------
    rs1877042361,2
    --2953302(+) AATAGA/GAGCCA 1 -- int10--------
    rs1922164091,2
    --2953638(+) AAGACC/TGCCTG 1 -- int10--------
    rs765416801,2
    C--2953663(+) ATCCTA/GTCTCT 1 -- int10--------
    rs1885220731,2
    --2953679(+) AAATAC/GAAAAA 1 -- int10--------
    rs19679591,2
    C,F,A--2953703(-) GCGCCC/TGCCAC 1 -- int18Minor allele frequency- T:0.40NA WA CSA 15
    rs1927281211,2
    --2953739(+) TGAGGC/TAGGAG 1 -- int10--------
    rs341289911,2
    C--2953837(+) AAAGA-/AAAAAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs2014752901,2
    --2954005(+) ACCTCA/CAGCTT 2 L syn10--------
    rs617471441,2
    C,F--2954057(+) TCTTCA/TTCCTG 2 K M mis14Minor allele frequency- T:0.02NS WA NA 4736

    HapMap Linkage Disequilibrium report for NOP14 (2939660 - 2965118 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NOP14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726866CNV Deletion23290073
    esv2726865CNV Deletion23290073
    esv2726835CNV Deletion23290073
    esv1551216CNV Deletion17803354
    esv1774334CNV Deletion17803354
    esv2726867CNV Deletion23290073
    esv1601449CNV Insertion17803354
    nsv878453CNV Loss21882294
    nsv290690CNV Loss16902084
    nsv461163CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NOP14
    DNA2.0 Custom Variant and Variant Library Synthesis for NOP14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 611526    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NOP14:
    Wolf-Hirschhorn syndrome

    Find genes that share disorders with NOP14           About GenesLikeMe


    Export disorders for NOP14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOP14 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with NOP14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. (PubMed id 9734812)1, 2, 3 Hadano S.... Ikeda J.-E. (DNA Res. 1998)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. (PubMed id 11694595)1, 3 Liu P.C. and Thiele D.J. (Mol. Biol. Cell 2001)
    5. Exon trapping and sequence-based methods of gene finding in transcript mapping of human 4p16.3. (PubMed id 9661704)1, 2 Pribill I.... MacDonald M.E. (Somat. Cell Mol. Genet. 1997)
    6. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
    7. NOP14 promotes proliferation and metastasis of pancreatic cancer cells. (PubMed id 22425761)1 Zhou B....Zhao Y.P. (Cancer Lett. 2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8602 HGNC: 16821 AceView: C4orf9 Ensembl:ENSG00000087269 euGenes: HUgn8602
    ECgene: NOP14 H-InvDB: NOP14

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NOP14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NOP14 gene:
    Search GeneIP for patents involving NOP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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