Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOP14 Gene

protein-coding   GIFtS: 47
GCID: GC04M002910

NOP14 Nucleolar Protein

(Previous names: chromosome 4 open reading frame 9, nucleolar protein 14,...)
(Previous symbols: C4orf9, NOL14)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NOP14 Nucleolar Protein1 2     NOP14 Nucleolar Protein Homolog (Yeast)1
NOL141 2 3 5     Nucleolar Protein 14 Homolog (Yeast)1
C4orf91 2 3     UTP22
Nucleolar Protein 141 2     NOP14 Homolog2
Nucleolar Complex Protein 142 3     NOP14 Nucleolar Protein Homolog2
RES4252 5     Nucleolar Protein 14 Homolog2
Chromosome 4 Open Reading Frame 91     Probable Nucleolar Complex Protein 142
NOP14 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 168211   Entrez Gene: 86022   Ensembl: ENSG000000872697   OMIM: 6115265   UniProtKB: P783163   

Export aliases for NOP14 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOP14 Gene:
NOP14 plays a role in the processing of the pre-18S rRNA and small ribosomal subunit assembly (Liu and Thiele,
2001 (PubMed 11694595)).(supplied by OMIM, Jun 2009)

GeneCards Summary for NOP14 Gene: 
NOP14 (NOP14 nucleolar protein) is a protein-coding gene. Diseases associated with NOP14 include wolf-hirschhorn syndrome, and huntington's disease. GO annotations related to this gene include snoRNA binding.

UniProtKB/Swiss-Prot: NOP14_HUMAN, P78316
Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S
pre-ribosomal subunit to the cytoplasm (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOP14 gene promoter:
         E2F-4   E2F-5   Pax-5   GCNF   E47   c-Rel   CP2   GCNF-1   Hand1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOP14 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOP14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

NOP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOP14 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M002910:  view genomic region     (about GC identifiers)

Start:
2,939,660 bp from pter      End:
2,965,118 bp from pter
Size:
25,459 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOP14_HUMAN, P78316 (See protein sequence)
Recommended Name: Nucleolar protein 14  
Size: 857 amino acids; 97668 Da
Subunit: Component of the ribosomal small subunit (SSU) processome (By similarity)
Subcellular location: Nucleus, nucleolus (By similarity)
Sequence caution: Sequence=AAB97011.1; Type=Erroneous initiation;
Secondary accessions: D3DVR6 Q7LGI5 Q7Z6K0 Q8TBR6
Alternative splicing: 2 isoforms:  P78316-1   P78316-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOP14: NX_P78316

Explore proteomics data for NOP14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78316

  • NOP14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOP14 Protein Expression
    REFSEQ proteins: NP_003694.1  
    ENSEMBL proteins: 
     ENSP00000405068   ENSP00000315674   ENSP00000427415   ENSP00000381146  

    Human Recombinant Protein Products for NOP14: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NOP14
    GenScript Custom Purified and Recombinant Proteins Services for NOP14
    Novus Biologicals NOP14 Protein
    Novus Biologicals NOP14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus ISS--
    GO:0005739mitochondrion ISS--
    GO:003068690S preribosome ISS--
    GO:0030692Noc4p-Nop14p complex ISS--
    GO:0032040small-subunit processome ISS--

    NOP14 for ontologies           About GeneDecksing



    NOP14 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NOP14
    GenScript Custom Superior Antibodies Services for NOP14
    Novus Biologicals NOP14 Antibodies
    Abcam antibodies for NOP14
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for NOP14
    Search LSBio for Antibodies for NOP14 

    Assay Products for NOP14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NOP14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NOP14
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007276 Nop14

    Graphical View of Domain Structure for InterPro Entry P78316

    ProtoNet protein and cluster: P78316

    UniProtKB/Swiss-Prot: NOP14_HUMAN, P78316
    Similarity: Belongs to the NOP14 family


    NOP14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOP14_HUMAN, P78316
    Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S
    pre-ribosomal subunit to the cytoplasm (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030515snoRNA binding ISS--
         
    NOP14 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for NOP14:
     Decreased Hepatitis C virus re  Decreased viability of wild-ty  Increased S DNA content, incre  Increased gamma-H2AX phosphory 
     Nuclear 40S maturation defects  Nucleolar pre-40S maturation d  S arrest  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NOP14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOP14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOP14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOP14 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOP14
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NOP14
    SwitchGear 3'UTR luciferase reporter plasmidNOP14 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NOP14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOP14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOP14
    Sirion Biotech Customized adenovirus for overexpression of NOP14

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NOP14 (see all 5)
    OriGene ORF clones in mouse, rat for NOP14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOP14 (NM_003703)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOP14
    Sirion Biotech Customized lentivirus for stable overexpression of NOP14 
                         Customized lentivirus expression plasmids for stable overexpression of NOP14 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NOP14
    Search LifeMap BioReagents cell lines for NOP14
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOP14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOP14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for NOP14 (P783163 ENSP000003156744) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    SUMO2ENSP000004059654STRING: ENSP00000405965
    SIRT7ENSP000003294664STRING: ENSP00000329466
    UBCENSP000003448184STRING: ENSP00000344818
    NAT10ENSP000002578294STRING: ENSP00000257829
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS--
    GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS--
    GO:0000472endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS--
    GO:0000480endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS--
    GO:0006364rRNA processing ISS--

    NOP14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOP14

    Search CenterWatch for drugs/clinical trials and news about NOP14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOP14 gene: 
    NM_003703.1  

    Unigene Cluster for NOP14:

    NOP14 nucleolar protein
    Hs.627133  [show with all ESTs]
    Unigene Representative Sequence: AK292939
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507120 ENST00000416614(uc010icp.2 uc003ggj.1 uc003ggl.3 uc010icq.1)
    ENST00000314262 ENST00000502735 ENST00000398071
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOP14
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NOP14
    SwitchGear 3'UTR luciferase reporter plasmidNOP14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NOP14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOP14
    Clone
    Products:
         
    OriGene clones in human, mouse for NOP14 (see all 5)
    OriGene ORF clones in mouse, rat for NOP14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOP14 (NM_003703)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOP14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOP14
    Sirion Biotech Customized lentivirus for stable overexpression of NOP14 
                         Customized lentivirus expression plasmids for stable overexpression of NOP14 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NOP14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOP14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOP14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOP14

    Additional mRNA sequence: 

    AB000467.1 AF040965.1 AK024755.1 AK025692.1 AK292939.1 BC009760.2 BC017358.1 BC026035.1 
    BC053635.1 L37199.1 

    18 DOTS entries:

    DT.100795025  DT.100765045  DT.95210850  DT.114803  DT.97771622  DT.100795021  DT.95171069  DT.97765729 
    DT.100861760  DT.100836939  DT.100795022  DT.449146  DT.92441183  DT.95148899  DT.100795024  DT.121237124 
    DT.97823770  DT.99955988 

    24/162 AceView cDNA sequences (see all 162):

    AA830889 BF981255 BC026035 BQ056037 CR612484 AF040965 BQ061722 BE543128 
    BM825477 BE397579 AA503745 AB000467 CR614906 AK025692 BQ642841 D44629 
    BU146481 BU849920 AU142372 CF125677 R06835 BQ217992 BX093602 BQ688621 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NOP14 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                      -     -     -     -   
    SP5:                                                                          -                                                                                 

    ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c
    SP1:                                -               
    SP2:        -     -     -     -                     
    SP3:                                                
    SP4:  -     -     -     -     -                     
    SP5:                                                


    ECgene alternative splicing isoforms for NOP14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOP14 expression in normal human tissues (normalized intensities)      NOP14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGAATTT
    NOP14 Expression
    About this image


    NOP14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Umbilical Cord (Extraembryonic Tissues)
             cord blood   
     
     Blood (Extraembryonic Tissues)
             cord blood   
     
     Lower Urinary Tract (Urinary System)
             visceral organ/bladder   
     
     Lymph (Hematopoietic System)

    See NOP14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOP14

    SOURCE GeneReport for Unigene cluster: Hs.627133
        SABiosciences Custom PCR Arrays for NOP14
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NOP14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOP14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOP14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOP14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOP14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOP14 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nop141 , 5 NOP14 nucleolar protein homolog (yeast)5
    NOP14 nucleolar protein1
    82.14(n)1
    83.7(a)1
      5 (17.91 cM)5
    754161  NM_029278.21  NP_083554.21 
     346385325 
    chicken
    (Gallus gallus)
    Aves NOP141 NOP14 nucleolar protein homolog (yeast) 67.69(n)
    67.49(a)
      422880  XM_420824.3  XP_420824.2 
    lizard
    (Anolis carolinensis)
    Reptilia NOP146
    Uncharacterized protein
    63(a)
    1 ↔ 1
    5(80187291-80217126)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256982 Xenopus laevis transcribed sequence with weak similarity more 78.06(n)    BU906315.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK028302.12   -- 72.64(n)   321133  CK028302.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)078821 lethal (3) 07882 46.15(n)
    35.89(a)
      46201  NM_143783.2  NP_652040.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G1A.41 Protein Y48G1A.4 44.4(n)
    32.04(a)
      171622  NM_170793.3  NP_740774.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOP14(YDL148C)4
    NOP141
    Nucleolar protein, forms a complex with Noc4p that more4
    Nop14p1
    43.92(n)1
    29.93(a)1
      4(190586-188154)4
    8514071, 4  NP_010133.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G690701 hypothetical protein 44.06(n)
    32.89(a)
      843239  NM_105577.2  NP_177070.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g05982001 hypothetical protein 44.91(n)
    33.13(a)
      4333384  NM_001057144.1  NP_001050609.1 


    ENSEMBL Gene Tree for NOP14 (if available)
    TreeFam Gene Tree for NOP14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/309 SNPs in NOP14 are shown (see all 309)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0600754
    ----see VAR_0600752 Q R mis40--------
    VAR_0535404
    ----see VAR_0535402 L S mis40--------
    rs1834290091,2
    C--2953299(+) GAGAAG/TAGGAG 1 -- int10--------
    rs1877042361,2
    --2953302(+) AATAGA/GAGCCA 1 -- int10--------
    rs1922164091,2
    --2953638(+) AAGACC/TGCCTG 1 -- int10--------
    rs765416801,2
    C--2953663(+) ATCCTA/GTCTCT 1 -- int10--------
    rs1885220731,2
    --2953679(+) AAATAC/GAAAAA 1 -- int10--------
    rs19679591,2
    C,F,A--2953703(-) GCGCCC/TGCCAC 1 -- int18Minor allele frequency- T:0.40NA WA CSA 15
    rs1927281211,2
    --2953739(+) TGAGGC/TAGGAG 1 -- int10--------
    rs341289911,2
    C--2953837(+) AAAGA-/AAAAAA 1 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for NOP14 (2939660 - 2965118 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NOP14:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726866CNV Deletion23290073
    esv2726865CNV Deletion23290073
    esv2726835CNV Deletion23290073
    esv1551216CNV Deletion17803354
    esv1774334CNV Deletion17803354
    esv2726867CNV Deletion23290073
    esv1601449CNV Insertion17803354
    nsv878453CNV Loss21882294
    nsv290690CNV Loss16902084
    nsv461163CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NOP14
    DNA2.0 Custom Variant and Variant Library Synthesis for NOP14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611526    OMIM disorders: --

    2 diseases for NOP14:    About MalaCards
    wolf-hirschhorn syndrome    huntington's disease

    1 disease from the University of Copenhagen DISEASES database for NOP14:
    Wolf-Hirschhorn syndrome

    NOP14 for disorders           About GeneDecksing


    Export disorders for NOP14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOP14 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with NOP14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. (PubMed id 9734812)1, 2, 3 Hadano S.... Ikeda J.-E. (1998)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. (PubMed id 11694595)1, 3 Liu P.C. and Thiele D.J. (2001)
    5. Exon trapping and sequence-based methods of gene finding in transcript mapping of human 4p16.3. (PubMed id 9661704)1, 2 Pribill I.... MacDonald M.E. (1997)
    6. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (2013)
    7. NOP14 promotes proliferation and metastasis of pancrea tic cancer cells. (PubMed id 22425761)1 Zhou B....Zhao Y.P. (2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O....Lill R. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8602 HGNC: 16821 AceView: C4orf9 Ensembl:ENSG00000087269 euGenes: HUgn8602
    ECgene: NOP14 H-InvDB: NOP14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOP14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOP14 gene:
    Search GeneIP for patents involving NOP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NOP14  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NOP14  
     OriGene qSTAR qPCR primer pairs in human, mouse for NOP14   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NOP14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NOP14   OriGene Custom Protein Services for NOP14  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOP14
     QIAGEN SeqTarget long-range PCR primers for resequencing NOP14
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOP14
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOP14
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOP14
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOP14
     GenScript Custom Purified and Recombinant Proteins Services for NOP14 GenScript cDNA clones with any tag delivered in your preferred vector for NOP14
     GenScript Custom Assay Services for NOP14 GenScript Custom Superior Antibodies Services for NOP14
     GenScript Custom overexpressing Cell Line Services for NOP14 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NOP14 promoter
     Search Chromatin IP Primers for NOP14
     RT2 qPCR Primer Assay in human, mouse, rat NOP14
     Search GNC Networks for NOP14
     SABiosciences Custom PCR Arrays for NOP14
     Search Tocris compounds for NOP14
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NOP14 antibodies
     NOP14 proteins
     NOP14 lysates
     Antibodies for NOP14
     See all of Abcam's Antibodies, Kits and Proteins for NOP14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for NOP14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOP14
     SwitchGear 3'UTR luciferase reporter plasmids for NOP14
     SwitchGear Promoter luciferase reporter plasmids for NOP14
     Search ThermoFisher Antibodies for NOP14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOP14
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NOP14
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOP14
    Customized:
     lentivirus for stable overexpression of NOP14
     lentivirus expression plasmids for stable overexpression of NOP14
     adenovirus for overexpression of NOP14
     Search LSBio for Antibodies for NOP14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NOP14 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4