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Aliases for NOP14 Gene

Aliases for NOP14 Gene

  • NOP14 Nucleolar Protein 2 3
  • NOL14 3 4 6
  • Nucleolar Protein 14 2 3
  • C4orf9 3 4
  • RES425 3 6
  • NOP14 Nucleolar Protein Homolog (Yeast) 2
  • Probable Nucleolar Complex Protein 14 3
  • Nucleolar Protein 14 Homolog (Yeast) 2
  • Chromosome 4 Open Reading Frame 9 2
  • NOP14 Nucleolar Protein Homolog 3
  • NOP14 Homolog (S. Cerevisiae) 2
  • Nucleolar Complex Protein 14 4
  • RES4-25 3
  • NOP14 6
  • UTP2 3

External Ids for NOP14 Gene

Previous HGNC Symbols for NOP14 Gene

  • C4orf9
  • NOL14

Previous GeneCards Identifiers for NOP14 Gene

  • GC04M002910

Summaries for NOP14 Gene

Entrez Gene Summary for NOP14 Gene

  • This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for NOP14 Gene

NOP14 (NOP14 Nucleolar Protein) is a Protein Coding gene. GO annotations related to this gene include snoRNA binding.

UniProtKB/Swiss-Prot for NOP14 Gene

  • Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP14 Gene

Genomics for NOP14 Gene

Regulatory Elements for NOP14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NOP14 Gene

Start:
2,937,933 bp from pter
End:
2,963,506 bp from pter
Size:
25,574 bases
Orientation:
Minus strand

Genomic View for NOP14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP14 Gene

Proteins for NOP14 Gene

  • Protein details for NOP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78316-NOP14_HUMAN
    Recommended name:
    Nucleolar protein 14
    Protein Accession:
    P78316
    Secondary Accessions:
    • D3DVR6
    • Q7LGI5
    • Q7Z6K0
    • Q8TBR6

    Protein attributes for NOP14 Gene

    Size:
    857 amino acids
    Molecular mass:
    97668 Da
    Quaternary structure:
    • Component of the ribosomal small subunit (SSU) processome.
    SequenceCaution:
    • Sequence=AAB97011.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOP14 Gene

Proteomics data for NOP14 Gene at MOPED

Post-translational modifications for NOP14 Gene

  • Ubiquitination at Lys834
  • Modification sites at PhosphoSitePlus

Other Protein References for NOP14 Gene

No data available for DME Specific Peptides for NOP14 Gene

Domains for NOP14 Gene

Protein Domains for NOP14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78316

UniProtKB/Swiss-Prot:

NOP14_HUMAN :
  • P78316
Family:
  • Belongs to the NOP14 family.
genes like me logo Genes that share domains with NOP14: view

No data available for Gene Families for NOP14 Gene

Function for NOP14 Gene

Molecular function for NOP14 Gene

UniProtKB/Swiss-Prot Function: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).

Gene Ontology (GO) - Molecular Function for NOP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23382074
GO:0030515 snoRNA binding ISS --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOP14: view
genes like me logo Genes that share phenotypes with NOP14: view

Animal Model Products

CRISPR Products

miRNA for NOP14 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOP14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NOP14 Gene

Localization for NOP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP14 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOP14 Gene COMPARTMENTS Subcellular localization image for NOP14 gene
Compartment Confidence
mitochondrion 4
nucleus 4
plasma membrane 3
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NOP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus ISS --
GO:0005739 mitochondrion ISS --
GO:0016020 membrane IDA 19946888
GO:0030686 90S preribosome ISS --
genes like me logo Genes that share ontologies with NOP14: view

Pathways for NOP14 Gene

SuperPathways for NOP14 Gene

No Data Available

Interacting Proteins for NOP14 Gene

Gene Ontology (GO) - Biological Process for NOP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS --
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS --
GO:0000472 endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS --
GO:0000480 endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS --
GO:0006364 rRNA processing ISS --
genes like me logo Genes that share ontologies with NOP14: view

No data available for Pathways by source for NOP14 Gene

Transcripts for NOP14 Gene

Unigene Clusters for NOP14 Gene

NOP14 nucleolar protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOP14

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NOP14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOP14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^
SP1:
SP2:
SP3:
SP4: - - - -
SP5: -
SP6: -
SP7: -
SP8:

ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: - - - -
SP3:
SP4: - - - - -
SP5:
SP6:
SP7:
SP8: - -

Relevant External Links for NOP14 Gene

GeneLoc Exon Structure for
NOP14
ECgene alternative splicing isoforms for
NOP14

Expression for NOP14 Gene

mRNA expression in normal human tissues for NOP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOP14 Gene

SOURCE GeneReport for Unigene cluster for NOP14 Gene Hs.627133

genes like me logo Genes that share expressions with NOP14: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOP14 Gene

Orthologs for NOP14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOP14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOP14 35
  • 99.46 (n)
  • 99.3 (a)
NOP14 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOP14 35
  • 77.87 (n)
  • 78.46 (a)
NOP14 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOP14 35
  • 80.86 (n)
  • 80.43 (a)
NOP14 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nop14 35
  • 81.93 (n)
  • 83.51 (a)
Nop14 16
Nop14 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOP14 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nop14 35
  • 82.24 (n)
  • 83.57 (a)
chicken
(Gallus gallus)
Aves NOP14 35
  • 67.38 (n)
  • 67.22 (a)
NOP14 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOP14 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25698 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394902 35
nop14 35
  • 64.44 (n)
  • 62.22 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
nop14 35
  • 59.19 (n)
  • 54.92 (a)
NOP14 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000397 35
  • 45.31 (n)
  • 32.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)07882 35
  • 46.03 (n)
  • 35.64 (a)
l(3)07882 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y48G1A.4 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP14 36
  • 25 (a)
OneToOne
NOP14 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69070 35
  • 43.9 (n)
  • 32.8 (a)
rice
(Oryza sativa)
Liliopsida Os03g0598200 35
  • 45.53 (n)
  • 34.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for NOP14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOP14 Gene

ENSEMBL:
Gene Tree for NOP14 (if available)
TreeFam:
Gene Tree for NOP14 (if available)

Paralogs for NOP14 Gene

No data available for Paralogs for NOP14 Gene

Variants for NOP14 Gene

Sequence variations from dbSNP and Humsavar for NOP14 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1018789 -- 2,958,038(-) CAGCC(A/G)AGGGA intron-variant
rs1263328 -- 2,959,461(-) CGCCC(A/G)CCACC intron-variant
rs1263329 -- 2,959,402(-) TGTTA(C/G)CCAGG intron-variant
rs1263330 -- 2,959,389(-) GGTCT(A/C/T)GATCT intron-variant
rs1269355 -- 2,960,056(-) GCAGG(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOP14 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV Deletion 23290073
nsv461163 CNV Gain 19166990
esv2726865 CNV Deletion 23290073
esv2726866 CNV Deletion 23290073
esv2726867 CNV Deletion 23290073
esv1551216 CNV Deletion 17803354
esv1774334 CNV Deletion 17803354
nsv290690 CNV Loss 16902084
esv1601449 CNV Insertion 17803354
nsv878453 CNV Loss 21882294

Relevant External Links for NOP14 Gene

HapMap Linkage Disequilibrium report
NOP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP14 Gene

Disorders for NOP14 Gene

(1) University of Copenhagen DISEASES for NOP14 Gene

genes like me logo Genes that share disorders with NOP14: view

No data available for UniProtKB/Swiss-Prot for NOP14 Gene

Publications for NOP14 Gene

  1. The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. (PMID: 9734812) Hadano S. … Ikeda J.-E. (DNA Res. 1998) 2 3 4
  2. Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. (PMID: 11694595) Liu P.C. … Thiele D.J. (Mol. Biol. Cell 2001) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Exon trapping and sequence-based methods of gene finding in transcript mapping of human 4p16.3. (PMID: 9661704) Pribill I. … MacDonald M.E. (Somat. Cell Mol. Genet. 1997) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for NOP14 Gene

Sources for NOP14 Gene

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