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Aliases for NOP14 Gene

Aliases for NOP14 Gene

  • NOP14 Nucleolar Protein 2 3 5
  • C4orf9 3 4
  • NOL14 3 4
  • NOP14 Nucleolar Protein Homolog (Yeast) 2
  • Probable Nucleolar Complex Protein 14 3
  • Nucleolar Protein 14 Homolog (Yeast) 2
  • Chromosome 4 Open Reading Frame 9 2
  • NOP14 Nucleolar Protein Homolog 3
  • NOP14 Homolog (S. Cerevisiae) 2
  • Nucleolar Complex Protein 14 4
  • Nucleolar Protein 14 2
  • RES4-25 3
  • RES425 3
  • UTP2 3

External Ids for NOP14 Gene

Previous HGNC Symbols for NOP14 Gene

  • C4orf9
  • NOL14

Previous GeneCards Identifiers for NOP14 Gene

  • GC04M002910

Summaries for NOP14 Gene

Entrez Gene Summary for NOP14 Gene

  • This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for NOP14 Gene

NOP14 (NOP14 Nucleolar Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding and snoRNA binding.

UniProtKB/Swiss-Prot for NOP14 Gene

  • Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOP14 Gene

Genomics for NOP14 Gene

Regulatory Elements for NOP14 Gene

Promoters for NOP14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOP14 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOP14 Gene

Chromosome:
4
Start:
2,937,933 bp from pter
End:
2,963,506 bp from pter
Size:
25,574 bases
Orientation:
Minus strand

Genomic View for NOP14 Gene

Genes around NOP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOP14 Gene

Proteins for NOP14 Gene

  • Protein details for NOP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78316-NOP14_HUMAN
    Recommended name:
    Nucleolar protein 14
    Protein Accession:
    P78316
    Secondary Accessions:
    • D3DVR6
    • Q7LGI5
    • Q7Z6K0
    • Q8TBR6

    Protein attributes for NOP14 Gene

    Size:
    857 amino acids
    Molecular mass:
    97668 Da
    Quaternary structure:
    • Component of the ribosomal small subunit (SSU) processome.
    SequenceCaution:
    • Sequence=AAB97011.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NOP14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOP14 Gene

Proteomics data for NOP14 Gene at MOPED

Post-translational modifications for NOP14 Gene

  • Ubiquitination at Lys 834
  • Modification sites at PhosphoSitePlus

Other Protein References for NOP14 Gene

No data available for DME Specific Peptides for NOP14 Gene

Domains & Families for NOP14 Gene

Protein Domains for NOP14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78316

UniProtKB/Swiss-Prot:

NOP14_HUMAN :
  • Belongs to the NOP14 family.
Family:
  • Belongs to the NOP14 family.
genes like me logo Genes that share domains with NOP14: view

No data available for Gene Families for NOP14 Gene

Function for NOP14 Gene

Molecular function for NOP14 Gene

UniProtKB/Swiss-Prot Function:
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).
genes like me logo Genes that share phenotypes with NOP14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NOP14

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOP14 Gene

Localization for NOP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOP14 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOP14 Gene COMPARTMENTS Subcellular localization image for NOP14 gene
Compartment Confidence
nucleus 5
mitochondrion 4
plasma membrane 3
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NOP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus ISS --
GO:0005739 mitochondrion ISS --
GO:0030692 Noc4p-Nop14p complex ISS --
genes like me logo Genes that share ontologies with NOP14: view

Pathways & Interactions for NOP14 Gene

genes like me logo Genes that share pathways with NOP14: view

Pathways by source for NOP14 Gene

Interacting Proteins for NOP14 Gene

Gene Ontology (GO) - Biological Process for NOP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS --
GO:0000472 endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS --
GO:0006364 rRNA processing ISS,TAS --
genes like me logo Genes that share ontologies with NOP14: view

No data available for SIGNOR curated interactions for NOP14 Gene

Drugs & Compounds for NOP14 Gene

No Compound Related Data Available

Transcripts for NOP14 Gene

Unigene Clusters for NOP14 Gene

NOP14 nucleolar protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOP14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b · 15c ^
SP1:
SP2:
SP3:
SP4: - - - -
SP5: -
SP6: -
SP7: -
SP8:

ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: - - - -
SP3:
SP4: - - - - -
SP5:
SP6:
SP7:
SP8: - -

Relevant External Links for NOP14 Gene

GeneLoc Exon Structure for
NOP14
ECgene alternative splicing isoforms for
NOP14

Expression for NOP14 Gene

mRNA expression in normal human tissues for NOP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOP14 Gene

This gene is overexpressed in Cervix (14.5), CD8 Tcells (12.0), and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOP14 Gene



SOURCE GeneReport for Unigene cluster for NOP14 Gene Hs.627133

genes like me logo Genes that share expression patterns with NOP14: view

Protein tissue co-expression partners for NOP14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOP14 Gene

Orthologs for NOP14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOP14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOP14 35
  • 77.87 (n)
  • 78.46 (a)
NOP14 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOP14 35
  • 80.86 (n)
  • 80.43 (a)
NOP14 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nop14 35
  • 81.93 (n)
  • 83.51 (a)
Nop14 16
Nop14 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOP14 35
  • 99.46 (n)
  • 99.3 (a)
NOP14 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nop14 35
  • 82.24 (n)
  • 83.57 (a)
oppossum
(Monodelphis domestica)
Mammalia NOP14 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves NOP14 35
  • 67.38 (n)
  • 67.22 (a)
NOP14 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOP14 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394902 35
nop14 35
  • 64.44 (n)
  • 62.22 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25698 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
nop14 35
  • 59.19 (n)
  • 54.92 (a)
NOP14 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000397 35
  • 45.31 (n)
  • 32.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)07882 35
  • 46.03 (n)
  • 35.64 (a)
l(3)07882 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y48G1A.4 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP14 36
  • 25 (a)
OneToOne
NOP14 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69070 35
  • 43.9 (n)
  • 32.8 (a)
rice
(Oryza sativa)
Liliopsida Os03g0598200 35
  • 45.53 (n)
  • 34.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for NOP14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOP14 Gene

ENSEMBL:
Gene Tree for NOP14 (if available)
TreeFam:
Gene Tree for NOP14 (if available)

Paralogs for NOP14 Gene

No data available for Paralogs for NOP14 Gene

Variants for NOP14 Gene

Sequence variations from dbSNP and Humsavar for NOP14 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_053540 -
VAR_060075 -
rs1018789 -- 2,958,038(-) CAGCC(A/G)AGGGA intron-variant
rs1475975 -- 2,953,738(-) GAGTG(A/G)TCACT intron-variant
rs1475976 -- 2,953,465(-) CTTGG(C/G)TGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOP14 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV Deletion 23290073
nsv461163 CNV Gain 19166990
esv2726865 CNV Deletion 23290073
esv2726866 CNV Deletion 23290073
esv2726867 CNV Deletion 23290073
esv1551216 CNV Deletion 17803354
esv1774334 CNV Deletion 17803354
nsv290690 CNV Loss 16902084
esv1601449 CNV Insertion 17803354
nsv878453 CNV Loss 21882294

Variation tolerance for NOP14 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.74; 94.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOP14 Gene

HapMap Linkage Disequilibrium report
NOP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOP14 Gene

Disorders for NOP14 Gene

Relevant External Links for NOP14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOP14

No disorders were found for NOP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOP14 Gene

Publications for NOP14 Gene

  1. The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. (PMID: 9734812) Hadano S. … Ikeda J.-E. (DNA Res. 1998) 2 3 4 67
  2. Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. (PMID: 11694595) Liu P.C. … Thiele D.J. (Mol. Biol. Cell 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PMID: 23382074) Armour S.M. … Sinclair D.A. (Mol. Cell. Biol. 2013) 3

Products for NOP14 Gene

Sources for NOP14 Gene

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