NONO Gene
protein-coding GIFtS: 61
GCID: GC0XP070503
|
|
non-POU domain containing, octamer-binding(Previous names: non-POU-domain-containing, octamer-binding )
| |
Aliases
for NONO gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Non-POU Domain Containing, Octamer-Binding1 2 | | DNA-Binding P52/P100 Complex, 52 KDa Subunit2 3 | | NRB541 2 3 5 | | P54(Nrb)1 | | NMT551 2 3 | | Non-POU-Domain-Containing, Octamer-Binding1 | | P541 2 | | Non-POU Domain-Containing Octamer (ATGCAAAT) Binding Protein2 | | P54NRB1 2 | | Non-POU Domain-Containing Octamer-Binding Protein2 | | 54 KDa Nuclear RNA- And DNA-Binding Protein2 3 | | NonO Protein3 | | 55 KDa Nuclear Protein2 3 | | P54nrb1 |
Export aliases for NONO gene to outside databasesPrevious GC identifers: GC0XP066677 GC16M070209 GC16M069524 GC16M069565 GC0XP069370 GC0XP070286 GC0XP070420 GC0XP064319 |
Summaries
for NONO gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NONO:
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulationand RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed inpapillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist onChromosomes 2 and 16. (provided by RefSeq, Feb 2009)
UniProtKB/Swiss-Prot: NONO_HUMAN, Q15233Function: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequencein double stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site (Bysimilarity). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably bybinding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. The SFPQ-NONO heteromer associated withMATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwindingby modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA nonhomologous endjoining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. Invitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with theKu70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptionalregulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependenttranscriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal Aparticles (IAPs) and activates transcription (By similarity). Together with PSPC1, required for the formation ofnuclear paraspeckles
Gene Wiki entry for NONO
|
Genomic Views
for NONO gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NONO gene promoter:
CREB POU2F1 POU2F1a deltaCREB ARP-1 YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NONO
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NONO |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1NONO Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP070503: view genomic region
(about GC identifiers)
Start:
|
70,503,042 bp from pter |
End:
|
70,521,018 bp from pter |
Size:
|
17,977 bases |
Orientation:
|
plus strand |
|
Proteins
for NONO gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NONO_HUMAN, Q15233 (See
protein sequence)Recommended Name: Non-POU domain-containing octamer-binding protein Size: 471 amino acids; 54232 Da
Subunit: Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) andtwo 100 kDa (SFPQ) subunits. NONO is a component of spliceosome and U5.4/6 snRNP complexes. Interacts with PSPC1 andSNRPA/U1A. Part of complex consisting of SFPQ, NONO and MATR3. Part of a complex consisting of SFPQ, NONO and NR5A1.Part of a complex consisting of SFPQ, NONO and TOP1. Interacts with SPI1 (By similarity). Interacts with RNF43. Formsheterodimers with PSPC1; this involves formation of a coiled coil domain by helices from both proteins
Subcellular location: Nucleus. Nucleus, nucleolus. Nucleus speckle. Note=Detected in punctate subnuclear structuresoften located adjacent to splicing speckles, called paraspeckles
1 PDB 3D structure from  and Proteopedia  for NONO:3SDE (3D)
Secondary accessions: B7Z4C2 D3DVV4 F5GYZ3 O00201 P30807 Q12786 Q9BQC5Alternative splicing: 2 isoforms: Q15233-1 Q15233-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NONO: NX_Q15233
Post-translational modifications:
The N-terminus is blocked1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15233
NONO Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001138880.1 NP_001138881.1 NP_001138882.1 NP_031389.3
ENSEMBL proteins: ENSP00000276079 ENSP00000362963 ENSP00000362947 ENSP00000410299 ENSP00000413350 ENSP00000415777 ENSP00000406673 ENSP00000409773 ENSP00000441364
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NONO for ontologies About GeneDecksing
NONO Antibody Products:
Assay Products for NONO: |
Protein
Domains /
Families
for NONO gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NONO for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15233ProtoNet protein and cluster: Q15233 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB012975 NOPS
UniProtKB/Swiss-Prot: NONO_HUMAN, Q15233Similarity: Contains 2 RRM (RNA recognition motif) domains |
Function
for NONO gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NONO_HUMAN, Q15233Function: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequencein double stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site (Bysimilarity). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably bybinding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. The SFPQ-NONO heteromer associated withMATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwindingby modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA nonhomologous endjoining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. Invitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with theKu70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptionalregulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependenttranscriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal Aparticles (IAPs) and activates transcription (By similarity). Together with PSPC1, required for the formation ofnuclear paraspeckles
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NONO (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NONO (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): NONO (NM_001145409) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NONO | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NONO |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NONO |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
NONO for ontologies About GeneDecksing
Animal Models:
3 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Nono):
NONO for phenotypes About GeneDecksing
|
Pathways & Interactions
for NONO gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcription_Sin3 and NuRD in transcription regulation | | | 2 | Circadian rhythm pathway | | | 3 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NONO
1  GeneGo (Thomson Reuters) Pathway for NONO
2  BioSystems Pathways for NONO
NONO for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NONO
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/836 Interacting proteins for NONO (Q152331, 2, 3 ENSP000002760794) via UniProtKB, MINT, STRING, and/or I2D (see all 836)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SMN1 | Q166372, 3, ENSP000003700834 | MINT-7945693 MINT-7947479 I2D:
score=2 STRING: ENSP00000370083 | | SMN2 | Q166372, 3, ENSP000003701194 | MINT-7945693 MINT-7947479 I2D:
score=2 STRING: ENSP00000370119 | | HDAC1 | Q135472, 3, ENSP000003626494 | MINT-7945693 MINT-7947479 I2D:
score=1 STRING: ENSP00000362649 | | SMARCB1 | Q128242, 3, ENSP000002631214 | MINT-7945693 MINT-7947479 I2D:
score=1 STRING: ENSP00000263121 | | SMARCD1 | Q96GM52, 3, ENSP000003784144 | MINT-7945693 MINT-7947479 I2D:
score=1 STRING: ENSP00000378414 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
NONO for ontologies About GeneDecksing
|
Drugs & Compounds
for NONO gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NONO for compounds About GeneDecksing
 Browse Tocris compounds for NONO
1 HMDB Compound for NONO About this table
2 Novoseek chemical compound relationships for NONO gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pyrimidine |
38.2 |
1 |
9756848 (1) |
| testosterone |
4.74 |
4 |
12672026 (2), 17452459 (2) |
Search CenterWatch for drugs/clinical trials and news about NONO
|
Transcripts
for NONO gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NONO gene (4 alternative transcripts): NM_001145408.1 NM_001145409.1 NM_001145410.1 NM_007363.4 Unigene Clusters for NONO: Non-POU domain containing, octamer-binding Hs.533282 [show with all ESTs], Hs.700344 [show with all ESTs]Unigene Representative Sequences: NM_001145408, BU94018017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000276079 ENST00000373856 ENST00000373841 ENST00000474431 ENST00000420903
ENST00000472185 ENST00000413858 ENST00000486613 ENST00000450092 ENST00000454976
ENST00000418921 ENST00000471419 ENST00000490044(uc004dzq.3) ENST00000471907
ENST00000481755 ENST00000473525 ENST00000535149(uc004dzo.3 uc004dzn.3 uc004dzp.3 uc011mpv.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NONO (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NONO (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): NONO (NM_001145409) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NONO | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NONO |
Additional cDNA sequence: L32558.1 24/104 DOTS entries (see all 104): DT.100888721 DT.100888708 DT.92469258 DT.92371968 DT.100832710 DT.100059997 DT.95364845 DT.92469289 DT.100888712 DT.121290668 DT.121290569 DT.102841558 DT.121290703 DT.121290627 DT.100888710 DT.121290620 DT.92057008 DT.121290608 DT.100888687 DT.121290667 DT.100888720 DT.100888697 DT.100059996 DT.100888718 24/2003 AceView cDNA sequences (see all 2003): BU624728 AW236435 BQ676483 BQ919356 BQ072234 BU527751 BU169929 BE296226 BU187860 BC012141 AI092020 BQ890178 BQ643267 BP358971 BQ229776 BU180870 BP368123 AA456510 BE205901 AW474184 BP352969 BQ653766 BU195173 BQ877362
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NONO (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NONO
|
Expression
for NONO gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NONO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTGCATTT
About this image
See NONO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NONO
SOURCE GeneReport for Unigene clusters: Hs.533282 Hs.700344
UniProtKB/Swiss-Prot: NONO_HUMAN, Q15233Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a numberof breast tumor cell lines
SABiosciences Expression via Pathway-Focused PCR Arrays including NONO:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NONO
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NONO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NONO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NONO | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NONO |
Orthologs
for NONO gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NONO gene from 7/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Nono1 , 5 |
non-POU-domain-containing, octamer binding protein1, 5 |
91.93(n)1
98.73(a)1 |
|
X (44.14 cM)5
536101 NM_023144.21 NP_075633.21
1014293185 |
chicken
(Gallus gallus) |
Aves |
NONO1 |
non-POU domain containing, octamer-binding |
79.51(n)
88.31(a) |
|
428701 NM_001031532.1 NP_001026703.1 |
lizard
(Anolis carolinensis) |
Reptilia |
NONO6 |
-- |
87(a) |
1 ↔ 1 |
GL343599.1(127197-132835) |
African clawed frog
(Xenopus laevis) |
Amphibia |
efna2-prov2 |
non-POU domain containing, octamer-binding |
76.1(n) |
|
BC045128.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
efna22 |
ephrin A2 |
75.33(n) |
|
30218 BC046880.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
nonA3 |
mRNA splicing RNA binding |
43(a)
(best of 2) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
F25B5.7a3 |
-- |
46(a) |
|
III(6025482-6029983) -- |
ENSEMBL Gene Tree for NONO (if available)
TreeFam Gene Tree for NONO (if available) |
Paralogs
for NONO gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NONO gene
- PSPC12 SFPQ2
3 SIMAP similar genes for NONO using alignment to 6 protein entries: NONO_HUMAN (see all proteins):SFPQ PSPC1 RBM4B
NONO for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for NONO
PGOHUM00000248305 PGOHUM00000248919 PGOHUM00000240055
|
Genomic Variants
for NONO gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NONO (70503042 - 70521018 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NONO
1 CNV: 7797 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NONO |
|
Disorders
/ Diseases
for NONO gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NONO for disorders About GeneDecksing
OMIM gene information: 300084
OMIM disorders: --
UniProtKB/Swiss-Prot: NONO_HUMAN, Q15233
Note=A chromosomal aberration involving NONO may be a cause of papillary renal cell carcinoma (PRCC).Translocation t(X;X)(p11.2;q13.1) with TFE3
20/23  diseases for NONO (see all 23): About MalaCardspapillary renal cell carcinoma renal cell carcinoma x-linked dystonia-parkinsonism dna topoisomerase i
carcinoma fanconi's anemia gastroenteritis embryonal carcinoma
parkinson's disease anemia cholera hepatocellular carcinoma
prostate cancer breast cancer ischemia myeloma
cerebritis prostatitis schizophrenia immunodeficiency
Human Genome Epidemiology (HuGE) Navigator: NONO (1 document)
Export disorders for NONO gene to outside databases
|
Publications
for NONO gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NONO gene, integrated from 9 sources (see all 135):
(articles sorted by number of sources associating them with NONO) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. (PubMed id 8371983)1, 2, 3, 9 Dong B.... Krainer A.R. (1993)
- Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen receptor-negative human breast cancer. (PubMed id 9360842)1, 2, 3 Traish A.M....Moreland R.B. (1997)
- Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma. (PubMed id 9393982)1, 2, 9 Clark J.... Cooper C.S. (1997)
- P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner. (PubMed id 16148043)1, 2, 9 Fox A.H.... Lamond A.I. (2005)
- The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction. (PubMed id 9756848)1, 2, 9 Straub T.... Boege F. (1998)
- Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins. (PubMed id 18655028)1, 2, 9 Miyamoto K.... Sugiura T. (2008)
- Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor. (PubMed id 15590677)1, 2, 9 Bladen C.L.... Dynan W.S. (2005)
- Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation. (PubMed id 22416126)1, 2 Passon D.M.... Bond C.S. (2012)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
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External Searches for NONO gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NONO gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NONO gene
(According to HUGE)
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Specialized Databases showing NONO gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for NONO gene:
Search GeneIP for patents involving NONO
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NONO gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for NONO | | OriGene shRNA RFP for NONO | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NONO | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NONO | | | OriGene Protein Over-expression Lysate for NONO | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NONO | | OriGene 3'-UTR Clone for NONO | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NONO | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NONO | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NONO | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NONO | | OriGene Custom Protein Services for NONO | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NONO | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NONO | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NONO | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NONO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NONO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NONO |
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| | | | Search Tocris compounds for NONO |
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 | | | NONO Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NONO |
|  |  |  | | | | ThermoFisher Antibody for NONO |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NONO |
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