Aliases for NOMO3 Gene
Aliases for NOMO3 Gene
External Ids for NOMO3 Gene
- HGNC: 25242
- Entrez Gene: 408050
- Ensembl: ENSG00000103226
- OMIM: 609159
- UniProtKB: P69849
Previous GeneCards Identifiers for NOMO3 Gene
- GC16P014835
- GC16P016233
- GC16U900522
- GC16P016326
Summaries for NOMO3 Gene
-
This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum. [provided by RefSeq, Jul 2008]
GeneCards Summary for NOMO3 Gene
NOMO3 (Nodal Modulator 3) is a Protein Coding gene. Diseases associated with NOMO3 include Pseudoxanthoma Elasticum and Superficial Urinary Bladder Cancer. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is NOMO1.
UniProtKB/Swiss-Prot for NOMO3 Gene
-
May antagonize Nodal signaling.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOMO3 Gene
Genomics for NOMO3 Gene
Regulatory Elements for NOMO3 Gene
Enhancers for NOMO3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH16G016092 | 1.1 | ENCODE dbSUPER | 5 | -139.0 | -138956 | 1.9 | ZFP64 RAD21 PCBP1 ZNF202 ZNF654 ZBTB11 ZNF426 ZNF623 ZNF781 ZNF518A | NPIPA5 LOC100505915 NOMO3 RPL17P40 GC16P016010 |
| GH16G016149 | 1.1 | Ensembl ENCODE | 4.8 | -82.1 | -82118 | 1.7 | ELF3 FOXA2 ARID4B ZNF48 RARA YY1 PCBP1 MIXL1 THAP11 PAF1 | NOMO3 C16orf45 PIR44788 GC16P016190 |
| GH16G015826 | 1.2 | Ensembl ENCODE dbSUPER | 4.4 | -404.1 | -404091 | 3.9 | BCOR ZNF133 ZMYM3 NR2F2 ZNF664 JUND HDAC2 ADNP ZNF512 KLF9 | MYH11 RNU6-213P FOPNL NPIPP1 ENSG00000227827 ENSG00000263335 NOMO3 ENSG00000280429 |
| GH16G016206 | 0.9 | Ensembl ENCODE | 5.4 | -25.0 | -24992 | 2.6 | PKNOX1 ESRRA SAP130 NR2F1 TAL1 CEBPG RARA TCF12 ARID1B RAD51 | NOMO3 LOC105371100 GC16P016190 |
| GH16G016232 | 0.7 | ENCODE | 0.7 | +0.0 | 4 | 0.2 | CTCF DRAP1 PKNOX1 MXI1 RB1 SAP130 ARID4B SIN3A GATAD1 ZNF143 | NOMO3 ENSG00000263029 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around NOMO3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the NOMO3 gene promoter:
Regulatory Element Products
Genomic Location for NOMO3 Gene
- Chromosome:
- 16
- Start:
- 16,232,495 bp from pter
- End:
- 16,294,814 bp from pter
- Size:
- 62,320 bases
- Orientation:
- Plus strand
Genomic View for NOMO3 Gene
Genes around NOMO3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.11 by Ensembl
- 16p13.11 by Entrez Gene
- 16p13.11 by HGNC
NOMO3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NOMO3 Gene
Proteins for NOMO3 Gene
-
Protein details for NOMO3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P69849-NOMO3_HUMAN
- Recommended name:
- Nodal modulator 3
- Protein Accession:
- P69849
Protein attributes for NOMO3 Gene
- Size:
- 1222 amino acids
- Molecular mass:
- 134134 Da
- Quaternary structure:
- No Data Available
Protein Expression for NOMO3 Gene
Post-translational modifications for NOMO3 Gene
Other Protein References for NOMO3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for NOMO3
- Invitrogen Antibodies for NOMO3
- Search GeneTex for Antibodies for NOMO3
-
Santa Cruz Biotechnology (SCBT) Antibodies for NOMO3
Protein Products
-
OriGene Purified Proteins for NOMO3
- Search Origene for MassSpec and Protein Over-expression Lysates for NOMO3
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- antibodies-online Proteins for NOMO3: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for NOMO3
-
Abcam proteins for NOMO3
No data available for DME Specific Peptides for NOMO3 Gene
Domains & Families for NOMO3 Gene
Protein Domains for NOMO3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NOMO3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for NOMO3 Gene
Function for NOMO3 Gene
Molecular function for NOMO3 Gene
- UniProtKB/Swiss-Prot Function:
- May antagonize Nodal signaling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for NOMO3 Gene
- GenomeRNAi human phenotypes for NOMO3:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for NOMO3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NOMO3 gene
- Search ViGene Biosciences for NOMO3
CRISPR Products
-
OriGene CRISPR knockouts for NOMO3
-
Santa Cruz Biotechnology (SCBT) CRISPR for NOMO3
- GenScript: Design CRISPR guide RNA sequences for NOMO3
miRNA for NOMO3 Gene
- miRTarBase miRNAs that target NOMO3
miRNA Products
- Search ViGene Biosciences for NOMO3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for NOMO3
- Browse OriGene Inhibitory RNA Products For NOMO3
-
ViGene Biosciences ready-to-package AAV shRNAs for NOMO3 gene
Clone Products
-
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- VectorBuilder custom plasmid, inducible vectors for NOMO3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NOMO3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for NOMO3
-
ViGene Biosciences adenoviral particle packaged cDNA for NOMO3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NOMO3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NOMO3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOMO3 Gene
Localization for NOMO3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NOMO3 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| extracellular | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for NOMO3 Gene
No Data Available
Interacting Proteins for NOMO3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for NOMO3 Gene
Transcripts for NOMO3 Gene
mRNA/cDNA for NOMO3 Gene
- (3) REFSEQ mRNAs :
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for NOMO3
-
Santa Cruz Biotechnology (SCBT) CRISPR for NOMO3
- GenScript: Design CRISPR guide RNA sequences for NOMO3
miRNA Products
- Search ViGene Biosciences for NOMO3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for NOMO3
- Browse OriGene Inhibitory RNA Products For NOMO3
-
ViGene Biosciences ready-to-package AAV shRNAs for NOMO3 gene
Clone Products
-
OriGene ORF clones in human for NOMO3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NOMO3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NOMO3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for NOMO3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Heart (39.0) and Brain (30.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOMO3 Gene
NURSA nuclear receptor signaling pathways regulating expression of NOMO3 Gene:
NOMO3Evidence on tissue expression from TISSUES for NOMO3 Gene
- Adrenal gland(2.4)
Primer Products
-
OriGene qPCR primer pairs for NOMO3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOMO3 Gene
Orthologs for NOMO3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| NOMO1 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| NOMO1 34 |
|
||||
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | Nomo1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Nomo1 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| PM5 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nomo3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nomo 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG1371 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005856 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | nra-4 34 35 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G62360 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0300600 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4870 35 |
|
OneToMany |
- Species where no ortholog for NOMO3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NOMO3 Gene
(3) SIMAP similar genes for NOMO3 Gene using alignment to 9 proteins:
Variants for NOMO3 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000052553 | -- | 16,269,149(+) | TATTG(C/T)TTCCT | intron-variant | |
| rs1000129157 | -- | 16,267,256(+) | GTTCA(A/G)CCTGC | intron-variant | |
| rs1000157373 | -- | 16,232,500(+) | CTGGG(G/T)CTGTG | upstream-variant-2KB | |
| rs1000332914 | -- | 16,242,246(+) | GCAAG(C/T)ACGTG | intron-variant | |
| rs1000445255 | -- | 16,232,176(+) | ACCCA(C/T)CTCAG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2775n100 | CNV | gain | 25217958 |
| dgv2776n100 | CNV | gain+loss | 25217958 |
| dgv2777n100 | CNV | loss | 25217958 |
| dgv4924n54 | CNV | gain | 21841781 |
| esv2714015 | CNV | deletion | 23290073 |
| esv2758633 | CNV | gain+loss | 17122850 |
| esv2762276 | CNV | gain+loss | 21179565 |
| esv28069 | CNV | gain+loss | 19812545 |
| esv33614 | CNV | gain+loss | 17666407 |
| esv3570398 | CNV | gain | 25503493 |
| nsv1047898 | CNV | loss | 25217958 |
| nsv1048002 | CNV | gain | 25217958 |
| nsv1049647 | CNV | gain+loss | 25217958 |
| nsv1125134 | CNV | deletion | 24896259 |
| nsv1143812 | CNV | deletion | 24896259 |
| nsv1144760 | CNV | deletion | 24896259 |
| nsv428319 | CNV | loss | 18775914 |
| nsv435664 | CNV | deletion | 17901297 |
| nsv457428 | CNV | gain | 19166990 |
| nsv469785 | CNV | gain+loss | 16826518 |
| nsv509599 | CNV | insertion | 20534489 |
| nsv9362 | CNV | loss | 18304495 |
| nsv9363 | CNV | loss | 18304495 |
| nsv984273 | CNV | duplication | 23825009 |
| nsv984274 | CNV | duplication | 23825009 |
Gene Damage Index Score:
6.33;
76.71% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NOMO3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NOMO3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOMO3 Gene
Disorders for NOMO3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pseudoxanthoma elasticum |
|
|
| superficial urinary bladder cancer |
|
|
| urinary bladder cancer |
|
|
Search NOMO3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for NOMO3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- NOMO3
No data available for UniProtKB/Swiss-Prot and Genatlas for NOMO3 Gene
Publications for NOMO3 Gene
- Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PMID: 15257293) Haffner C. … Haass C. (EMBO J. 2004) 2 3 64
- The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3 64
Products for NOMO3 Gene
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- VectorBuilder custom plasmid, inducible vectors for NOMO3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NOMO3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for NOMO3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer