Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

NOMO3 Gene

protein-coding GIFtS: 42
GCID: GC16P016326

NODAL Modulator 3

Try our

MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
NODAL Modulator 3¹ ²
PM5 Protein 3² ³
Nomo²
PM5 Protein, Middle Copy²

External Ids:	HGNC: 25242¹	Entrez Gene: 408050²	Ensembl: ENSG00000103226⁷	OMIM: 609159⁵	UniProtKB: P69849³

Export aliases for NOMO3 gene to outside databases

Previous GC identifers: GC16P014835 GC16P016233 GC16U900522

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NOMO3 Gene:

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of

three highly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode

closely related proteins that may have the same function. The protein encoded by one of these genes has been

identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate

development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with

pseudoxanthoma elasticum. (provided by RefSeq, Jul 2008)

GeneCards Summary for NOMO3 Gene:

NOMO3 (NODAL modulator 3) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is NOMO2.

UniProtKB/Swiss-Prot: NOMO3_HUMAN, P69849

Function: May antagonize Nodal signaling (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

Regulatory elements:

Regulatory transcription factor binding sites in the NOMO3 gene promoter:
GR Elk-1 AML1a Sp1 Lmo2 GATA-1 c-Ets-1 GR-alpha
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for NOMO3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOMO3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13 Ensembl cytogenetic band: 16p13.11 HGNC cytogenetic band: 16p13

NOMO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOMO3 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P016326: view genomic region (about GC identifiers)

Start:	16,326,352 bp from pter	End:	16,388,668 bp from pter
Size:	62,317 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NOMO3_HUMAN, P69849 (See protein sequence)

Recommended Name: Nodal modulator 3 precursor

Size: 1222 amino acids; 134134 Da

Caution: There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1 (AC Q5JPE7), NOMO2 (AC Q5JPE7) and

NOMO3. All 3 are extremely similar, which makes their individual characterization difficult. Thus, most

experiments probably do not discriminate between the different members. The results reported in other entries may

therefore apply for this protein

Explore the universe of human proteins at neXtProt for NOMO3: NX_P69849

Explore proteomics data for NOMO3 at MOPED

Post-translational modifications:

Ubiquitination² at Lys134, Lys138, Lys159, Lys170, Lys175, Lys193, Lys356, Lys630, Lys770, Lys927,
Lys1019, Lys1079

Glycosylation² at Asn50, Asn218, Asn369, Asn618

Modification sites at PhosphoSitePlus

See NOMO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001004067.1

ENSEMBL proteins:

ENSP00000382274 ENSP00000461721 ENSP00000263012 ENSP00000458267 ENSP00000458821

ENSP00000461870 ENSP00000459996 ENSP00000443768

NOMO3 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for NOMO3 OriGene Protein Over-expression Lysate for NOMO3 OriGene MassSpec for NOMO3 OriGene Custom Protein Services for NOMO3
	GenScript Custom Purified and Recombinant Proteins Services for NOMO3
	Novus Biologicals NOMO3 Protein Novus Biologicals NOMO3 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for NOMO3
	Search eBioscience for Proteins for NOMO3
	antibodies-online proteins for NOMO3 (2 products)
	Search antibodies-online for peptides for NOMO3

NOMO3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for NOMO3
	Novus Biologicals NOMO3 Antibody
	Search for Antibodies for NOMO3 at Abcam
	Cloud-Clone Corp. Antibodies for NOMO3
	Search ThermoFisher Antibodies for NOMO3
	antibodies-online antibodies for NOMO3

NOMO3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for NOMO3
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NOMO3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for NOMO3 Cloud-Clone Corp. CLIAs for NOMO3
	Search eBioscience for ELISAs for NOMO3
	antibodies-online kits for NOMO3 (2 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

4 InterPro protein domains:

IPR008969 CarboxyPept-like_regulatory

IPR013783 Ig-like_fold

IPR013784 Carb-bd-like_fold

IPR014766 CarboxyPept_regulatory_dom

Graphical View of Domain Structure for InterPro Entry P69849

ProtoNet protein and cluster: P69849

1 Blocks protein domain: IPB008454 Cna B-type

Find genes that share domains with NOMO3 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: NOMO3_HUMAN, P69849

Function: May antagonize Nodal signaling (By similarity)

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0030246	carbohydrate binding	IEA	--

Find genes that share ontologies with NOMO3 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for NOMO3

miRNA Products:		miRTarBase miRNAs that target NOMO3: hsa-mir-766-3p (MIRT039026), hsa-mir-877-3p (MIRT037055), hsa-mir-484 (MIRT041873), hsa-mir-615-3p (MIRT039922), hsa-mir-362-5p (MIRT044052), hsa-let-7b-5p (MIRT051891), hsa-mir-149-5p (MIRT045666)

		Block miRNA regulation of human, mouse, rat NOMO3 using miScript Target Protectors
		8 qRT-PCR Assays for microRNAs that regulate NOMO3:
		hsa-miR-4291 hsa-miR-922 hsa-miR-342-3p hsa-miR-33a hsa-miR-214 hsa-miR-542-3p hsa-miR-33b hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: NOMO3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NOMO3
		Predesigned siRNA for gene silencing in human, mouse, rat NOMO3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NOMO3

Clone Products:		OriGene clones in human, mouse for NOMO3 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NOMO3 (NM_001004067)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOMO3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOMO3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NOMO3
		Browse ESI BIO Cell Lines and PureStem Progenitors for NOMO3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

NOMO3_HUMAN, P69849: Membrane; Single-pass type I membrane protein (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	2
plasma membrane	2
endoplasmic reticulum	1
golgi apparatus	1
peroxisome	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0016021	integral component of membrane	IEA	--

Find genes that share ontologies with NOMO3 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for NOMO3
Interactions:

Search GeneGlobe Interaction Network for NOMO3

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

Selected Interacting proteins for NOMO3 (P69849^{2, 3} ENSP00000382274⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2879707 I2D: score=3 STRING: ENSP00000357292
NCLN	Q969V3³, ENSP00000246117⁴	I2D: score=1 STRING: ENSP00000246117
RYK	P34925³, ENSP00000296084⁴	I2D: score=1 STRING: ENSP00000296084
CAD	ENSP00000264705⁴	STRING: ENSP00000264705
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

Find genes that share ontologies with NOMO3 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for NOMO3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for NOMO3 gene:

NM_001004067.3

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000399336(uc002dep.3 uc010bvp.2 uc002deq.3) ENST00000576589

ENST00000263012 ENST00000575225 ENST00000572830 ENST00000570519 ENST00000576427

ENST00000576269 ENST00000576460 ENST00000572033 ENST00000574894 ENST00000574157

ENST00000572932 ENST00000573635 ENST00000571167 ENST00000570732 ENST00000570346

ENST00000538468

miRNA Products:		Block miRNA regulation of human, mouse, rat NOMO3 using miScript Target Protectors
		8 qRT-PCR Assays for microRNAs that regulate NOMO3:
		hsa-miR-4291 hsa-miR-922 hsa-miR-342-3p hsa-miR-33a hsa-miR-214 hsa-miR-542-3p hsa-miR-33b hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: NOMO3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NOMO3
		Predesigned siRNA for gene silencing in human, mouse, rat NOMO3

Clone Products:		OriGene clones in human, mouse for NOMO3 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NOMO3 (NM_001004067)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOMO3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOMO3

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for NOMO3
		Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat NOMO3
		QuantiTect SYBR Green Assays in human, mouse, rat NOMO3
		QuantiFast Probe-based Assays in human, mouse, rat NOMO3

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

NOMO3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCGGGGTACC

About this image

NOMO3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NOMO3 Protein Expression

Custom PCR Arrays for NOMO3

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for NOMO3
		Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat NOMO3
		QuantiTect SYBR Green Assays in human, mouse, rat NOMO3
		QuantiFast Probe-based Assays in human, mouse, rat NOMO3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOMO3 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nomo1¹	nodal modulator 1	86.37(n) 93.28(a)		211548 NM_153057.4 NP_694697.3
chicken (Gallus gallus)	Aves	PM5¹	pM5 protein	77.23(n) 87.14(a)		416602 XM_004945285.1 XP_004945342.1
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	86(a)	1 → many	GL343580.1(301242-312387)
tropical clawed frog (Xenopus tropicalis)	Amphibia	nomo3¹	NODAL modulator 3	72.13(n) 79.9(a)		100158535 NM_001127971.1 NP_001121443.1
zebrafish (Danio rerio)	Actinopterygii	nomo¹	nodal modulator	66.69(n) 70.85(a)		446115 XM_002662315.2 XP_002662361.1
fruit fly (Drosophila melanogaster)	Insecta	CG1371¹	CG1371	46.05(n) 34.28(a)		36053 NM_136707.2 NP_610551.1
worm (Caenorhabditis elegans)	Secernentea	nra-4¹	nra-4	43.06(n) 27.77(a)		3565008 NM_070966.3 NP_503367.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G62360¹	AT3G62360	45.03(n) 34.26(a)		825409 NM_116101.3 NP_191795.1
rice (Oryza sativa)	Liliopsida	Os01g0300600¹	Os01g0300600	45.37(n) 39.65(a)		4325779 NM_001049353.1 NP_001042818.2

ENSEMBL Gene Tree for NOMO3 (if available)
TreeFam Gene Tree for NOMO3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for NOMO3 gene

NOMO2¹ ² NOMO1¹ ²

3 SIMAP similar genes for NOMO3 using alignment to 9 protein entries: NOMO3_HUMAN (see all proteins):

DKFZp547A1913 NOMO1 NOMO2

Find genes that share paralogs with NOMO3 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149603479^1,2		--	16325013(+)	`CTCATA/GATTAT`	1	--	us2k¹		0	--	--	--	--
rs201012712^1,2	C	--	16325930(+)	`GTGTG-/GT/TG CGTGT`	1	--	us2k¹		0	--	--	--	--
rs140994940^1,2		--	16326030(+)	`TCCACC/TCACCT`	1	--	us2k¹		0	--	--	--	--
rs144648477^1,2	C	--	16326171(+)	`CCAACA/GAAATC`	1	--	us2k¹		0	--	--	--	--
rs147873265^1,2	C	--	16326364(+)	`TGTGAA/CCGTGG`	1	--	us2k¹		0	--	--	--	--
rs201681904^1,2	C	--	16327885(+)	`CTTTAA/GCAAGC`	1	--	int¹		0	--	--	--	--
rs9935495^1,2	C	--	16328533(+)	`GttcaT/Ctgagt`	1	--	int¹		1		NA	2
rs9922914^1,2	C	--	16328557(+)	`CTGAGC/TCCCGG`	1	--	int¹		0	--	--	--	--
rs9935584^1,2	C	--	16328634(+)	`tactcT/Ccatga`	1	--	int¹		1		NA	2
rs140835370^1,2		--	16328720(+)	`CAATCA/CGCAGG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NOMO3 (16326352 - 16388668 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for NOMO3 (see all 17): About this table

Variant ID	Type	Subtype	PubMed ID
nsv435664	CNV	Deletion	17901297
esv2714015	CNV	Deletion	23290073
nsv509599	CNV	Insertion	20534489
nsv9362	CNV	Loss	18304495
nsv428319	CNV	Loss	18775914
nsv9363	CNV	Loss	18304495
dgv2616n71	CNV	Gain	21882294
nsv905424	CNV	Gain	21882294
nsv457428	CNV	Gain	19166990
nsv905415	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing NOMO3

DNA2.0 Custom Variant and Variant Library Synthesis for NOMO3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 609159 OMIM disorders: --

Find genes that share disorders with NOMO3 About GenesLikeMe

Export disorders for NOMO3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for NOMO3 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with NOMO3)

Utopia: connect your pdf to the dynamic
world of online information

The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (Nature 2004)
Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PubMed id 15257293)^{1, 3} Haffner C.... Haass C. (EMBO J. 2004)
Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)^{1, 2} Loftus B.J.... Adams M.D. (Genomics 1999)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (Sci Signal 2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)¹ Liu B....Wang L.S. (J. Proteome Res. 2012)
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)¹ Berndt J.D....Moon R.T. (J. Cell Biol. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 408050	HGNC: 25242	Ensembl:ENSG00000103226	euGenes: HUgn408050	ECgene: NOMO3
H-InvDB: NOMO3

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for NOMO3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NOMO3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for NOMO3 gene:
Search GeneIP for patents involving NOMO3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for NOMO3
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for NOMO3
	OriGene MassSpec for NOMO3		OriGene clones in human, mouse for NOMO3
	OriGene qSTAR qPCR primer pairs in human, mouse for NOMO3		OriGene Purified Protein for NOMO3
	Browse OriGene ORF clones		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NOMO3		OriGene Custom Protein Services for NOMO3

	Block miRNA regulation of human, mouse, rat NOMO3 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing NOMO3
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOMO3		Predesigned siRNA for gene silencing in human, mouse, rat NOMO3
	QuantiFast Probe-based Assays in human, mouse, rat NOMO3		QuantiTect SYBR Green Assays in human, mouse, rat NOMO3
	Custom PCR Arrays for NOMO3		Search Chromatin IP Primers for NOMO3
	Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat NOMO3		Search GeneGlobe Interaction Network for NOMO3
	Regulatory tfbs in NOMO3 promoter

	GenScript Custom Purified and Recombinant Proteins Services for NOMO3		GenScript cDNA clones with any tag delivered in your preferred vector for NOMO3
	GenScript Custom Assay Services for NOMO3		GenScript Custom overexpressing Cell Line Services for NOMO3
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for NOMO3

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NOMO3 antibodies
	NOMO3 proteins
	NOMO3 lysates

	Search for Antibodies for NOMO3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for NOMO3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for NOMO3
	Antibodies for NOMO3
	ELISAs for NOMO3
	CLIAs for NOMO3

Browse ESI BIO Cell Lines and PureStem Progenitors for NOMO3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO3

	SwitchGear 3'UTR luciferase reporter plasmids for NOMO3
	Browse SwitchGear Promoter luciferase reporter plasmids for NOMO3

Search ThermoFisher Antibodies for NOMO3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOMO3

Browse compounds at ApexBio

Search Addgene for plasmids for NOMO3

	Search eBioscience for proteins for NOMO3
	Search eBioscience for elisas for NOMO3
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for NOMO3

	antibodies-online antibodies for NOMO3
	antibodies-online kits for NOMO3 (2 products)
	Search antibodies-online for peptides for NOMO3
	antibodies-online proteins for NOMO3 (2 products)

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NOMO3 gene at Home site.

Version: 3.12.300 21 Jan 2015
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

NOMO3 Gene

NODAL Modulator 3

Aliases
for NOMO3 gene

Summaries
for NOMO3 gene

Genomic Views
for NOMO3 gene

Proteins
for NOMO3 gene

NOMO3 Human Recombinant Protein Products:

NOMO3 Antibody Products:

NOMO3 Assay Products:

Domains /
Families
for NOMO3 gene

Function
for NOMO3 gene

Localization
for NOMO3 gene

Pathways & Interactions
for NOMO3 gene

Drugs & Compounds
for NOMO3 gene

Transcripts
for NOMO3 gene

Expression
for NOMO3 gene

Orthologs
for NOMO3 gene

Paralogs
for NOMO3 gene

Genomic Variants
for NOMO3 gene

Disorders / Diseases
for NOMO3 gene

Publications
for NOMO3 gene

External Searches for NOMO3 gene

Genome Databases showing NOMO3 gene

Other Databases showing NOMO3 gene

Specialized Databases showing NOMO3 gene

Intellectual Property
for NOMO3 gene

Products
for NOMO3 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

NOMO3 Gene

NODAL Modulator 3

Aliasesfor NOMO3 gene

Summariesfor NOMO3 gene

Genomic Viewsfor NOMO3 gene

Proteinsfor NOMO3 gene

NOMO3 Human Recombinant Protein Products:

NOMO3 Antibody Products:

NOMO3 Assay Products:

Domains /Familiesfor NOMO3 gene

Functionfor NOMO3 gene

Localizationfor NOMO3 gene

Pathways & Interactionsfor NOMO3 gene

Drugs & Compoundsfor NOMO3 gene

Transcriptsfor NOMO3 gene

Expression for NOMO3 gene

Orthologsfor NOMO3 gene

Paralogsfor NOMO3 gene

Genomic Variantsfor NOMO3 gene

Disorders / Diseasesfor NOMO3 gene

Publicationsfor NOMO3 gene

External Searches for NOMO3 gene

Genome Databases showing NOMO3 gene

Other Databases showing NOMO3 gene

Specialized Databases showing NOMO3 gene

Intellectual Propertyfor NOMO3 gene

Productsfor NOMO3 gene

View Random Gene

Aliases
for NOMO3 gene

Summaries
for NOMO3 gene

Genomic Views
for NOMO3 gene

Proteins
for NOMO3 gene

Domains /
Families
for NOMO3 gene

Function
for NOMO3 gene

Localization
for NOMO3 gene

Pathways & Interactions
for NOMO3 gene

Drugs & Compounds
for NOMO3 gene

Transcripts
for NOMO3 gene

Expression
for NOMO3 gene

Orthologs
for NOMO3 gene

Paralogs
for NOMO3 gene

Genomic Variants
for NOMO3 gene

Disorders / Diseases
for NOMO3 gene

Publications
for NOMO3 gene

Intellectual Property
for NOMO3 gene

Products
for NOMO3 gene