NOMO3 Gene
protein-coding GIFtS: 41
GCID: GC16P016326
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NODAL modulator 3
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Aliases
for NOMO3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NODAL Modulator 31 2 | | PM5 Protein 32 3 | | Nomo2 | | PM5 Protein, Middle Copy2 |
Export aliases for NOMO3 gene to outside databasesPrevious GC identifers: GC16P014835 GC16P016233 GC16U900522 |
Summaries
for NOMO3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NOMO3:
This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of threehighly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode closelyrelated proteins that may have the same function. The protein encoded by one of these genes has been identified aspart of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations inABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NOMO3_HUMAN, P69849Function: May antagonize Nodal signaling (By similarity)
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Genomic Views
for NOMO3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOMO3 gene promoter:
GR Elk-1 AML1a Sp1 Lmo2 GATA-1 c-Ets-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOMO3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOMO3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13 Ensembl cytogenetic band: 16p13.11 HGNC cytogenetic band: 16p13NOMO3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P016326: view genomic region
(about GC identifiers)
Start:
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16,326,352 bp from pter |
End:
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16,388,668 bp from pter |
Size:
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62,317 bases |
Orientation:
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plus strand |
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Proteins
for NOMO3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOMO3_HUMAN, P69849 (See
protein sequence)Recommended Name: Nodal modulator 3 precursor Size: 1222 amino acids; 134134 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Caution: There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1 (AC Q5JPE7), NOMO2 (AC Q5JPE7) and NOMO3.All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probablydo not discriminate between the different members. The results reported in other entries may therefore apply for thisproteinExplore the universe of human proteins at neXtProt for NOMO3: NX_P69849
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P69849
NOMO3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001004067.1
ENSEMBL proteins: ENSP00000382274 ENSP00000461721 ENSP00000263012 ENSP00000458267 ENSP00000458821 ENSP00000461870 ENSP00000459996 ENSP00000443768
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
NOMO3 for ontologies About GeneDecksing
NOMO3 Antibody Products:
Assay Products for NOMO3: |
Protein
Domains /
Families
for NOMO3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOMO3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P69849ProtoNet protein and cluster: P69849 1 Blocks protein family: IPB008454 Cna B-type
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Function
for NOMO3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NOMO3_HUMAN, P69849Function: May antagonize Nodal signaling (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO3
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004180 | carboxypeptidase activity |
IEA | -- | | GO:0030246 | carbohydrate binding |
IEA | -- |
NOMO3 for ontologies About GeneDecksing
|
Pathways & Interactions
for NOMO3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOMO3
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for NOMO3 (P698492, 3 ENSP000003822744) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for NOMO3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NOMO3
Search CenterWatch for drugs/clinical trials and news about NOMO3
|
Transcripts
for NOMO3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOMO3 gene: NM_001004067.3 18 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000399336(uc002dep.3 uc010bvp.2 uc002deq.3) ENST00000576589
ENST00000263012 ENST00000575225 ENST00000572830 ENST00000570519 ENST00000576427
ENST00000576269 ENST00000576460 ENST00000572033 ENST00000574894 ENST00000574157
ENST00000572932 ENST00000573635 ENST00000571167 ENST00000570732 ENST00000570346
ENST00000538468
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NOMO3 (NM_001004067) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOMO3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOMO3 |
GeneLoc Exon Structure
|
Expression
for NOMO3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOMO3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGGGGTACC
About this image
See NOMO3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOMO3
SABiosciences Custom PCR Arrays for NOMO3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOMO3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NOMO3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOMO3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOMO3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO3 |
Orthologs
for NOMO3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NOMO3 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for NOMO3 (if available)
TreeFam Gene Tree for NOMO3 (if available) |
Paralogs
for NOMO3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NOMO3 gene
- NOMO21 2 NOMO11 2
3 SIMAP similar genes for NOMO3 using alignment to 9 protein entries: NOMO3_HUMAN (see all proteins):DKFZp547A1913 NOMO1 NOMO2
NOMO3 for paralogs About GeneDecksing
|
Genomic Variants
for NOMO3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NOMO3 (16326352 - 16388668 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for NOMO3
6 CNVs: 72487 3111 3993 32090 7089 2204 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for NOMO3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NOMO3 for disorders About GeneDecksing
OMIM gene information: 609159
OMIM disorders: --
2  diseases for NOMO3: About MalaCardsataxia prostatitis
Export disorders for NOMO3 gene to outside databases
|
Publications
for NOMO3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOMO3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with NOMO3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
- Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PubMed id 15257293)1, 3 Haffner C....Haass C. (2004)
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Mindbomb 1, an E3 ubiquitin ligase, forms a complex w ith RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
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External Searches for NOMO3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NOMO3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOMO3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOMO3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOMO3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NOMO3 gene:
Search GeneIP for patents involving NOMO3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOMO3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NOMO3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOMO3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOMO3 | | | OriGene Protein Over-expression Lysate for NOMO3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NOMO3 | | OriGene 3'-UTR Clone for NOMO3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NOMO3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | NOMO3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO3 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOMO3 |
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