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Aliases for NOMO3 Gene

Aliases for NOMO3 Gene

  • Nodal Modulator 3 2 3
  • PM5 Protein 3 3 4
  • PM5 Protein, Middle Copy 3
  • NODAL Modulator 3 5
  • Nomo 3

External Ids for NOMO3 Gene

Previous GeneCards Identifiers for NOMO3 Gene

  • GC16P014835
  • GC16P016233
  • GC16U900522
  • GC16P016326

Summaries for NOMO3 Gene

Entrez Gene Summary for NOMO3 Gene

  • This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOMO3 Gene

NOMO3 (Nodal Modulator 3) is a Protein Coding gene. Diseases associated with NOMO3 include Pseudoxanthoma Elasticum and Superficial Urinary Bladder Cancer. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is NOMO2.

UniProtKB/Swiss-Prot for NOMO3 Gene

  • May antagonize Nodal signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOMO3 Gene

Genomics for NOMO3 Gene

Regulatory Elements for NOMO3 Gene

Enhancers for NOMO3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOMO3 on UCSC Golden Path with GeneCards custom track

Promoters for NOMO3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOMO3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOMO3 Gene

16,232,495 bp from pter
16,294,814 bp from pter
62,320 bases
Plus strand

Genomic View for NOMO3 Gene

Genes around NOMO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOMO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOMO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOMO3 Gene

Proteins for NOMO3 Gene

  • Protein details for NOMO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nodal modulator 3
    Protein Accession:

    Protein attributes for NOMO3 Gene

    1222 amino acids
    Molecular mass:
    134134 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NOMO3 Gene

Proteomics data for NOMO3 Gene at MOPED

Post-translational modifications for NOMO3 Gene

  • Glycosylation at Asn 50, Asn 218, and Asn 618
  • Modification sites at PhosphoSitePlus

Other Protein References for NOMO3 Gene

No data available for DME Specific Peptides for NOMO3 Gene

Domains & Families for NOMO3 Gene

Protein Domains for NOMO3 Gene

Suggested Antigen Peptide Sequences for NOMO3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOMO3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOMO3 Gene

Function for NOMO3 Gene

Molecular function for NOMO3 Gene

UniProtKB/Swiss-Prot Function:
May antagonize Nodal signaling.

Gene Ontology (GO) - Molecular Function for NOMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with NOMO3: view

Phenotypes for NOMO3 Gene

GenomeRNAi human phenotypes for NOMO3:
genes like me logo Genes that share phenotypes with NOMO3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOMO3 Gene

Localization for NOMO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOMO3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for NOMO3 Gene COMPARTMENTS Subcellular localization image for NOMO3 gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NOMO3 Gene

Pathways & Interactions for NOMO3 Gene

SuperPathways for NOMO3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOMO3 Gene


No data available for Pathways by source and SIGNOR curated interactions for NOMO3 Gene

Drugs & Compounds for NOMO3 Gene

No Compound Related Data Available

Transcripts for NOMO3 Gene

mRNA/cDNA for NOMO3 Gene

(3) REFSEQ mRNAs :
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NOMO3 Gene

No ASD Table

Relevant External Links for NOMO3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOMO3 Gene

mRNA expression in normal human tissues for NOMO3 Gene

Protein differential expression in normal tissues from HIPED for NOMO3 Gene

This gene is overexpressed in Heart (39.0) and Brain (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOMO3 Gene

genes like me logo Genes that share expression patterns with NOMO3: view

Protein tissue co-expression partners for NOMO3 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOMO3 Gene

Orthologs for NOMO3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOMO3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOMO1 35
  • 88.51 (n)
  • 94.91 (a)
-- 36
  • 95 (a)
(Canis familiaris)
Mammalia NOMO1 35
  • 90 (n)
  • 95.97 (a)
-- 36
  • 95 (a)
(Mus musculus)
Mammalia Nomo1 35
  • 86.37 (n)
  • 93.28 (a)
Nomo1 16
Nomo1 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Nomo1 35
  • 86.82 (n)
  • 93.69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
(Gallus gallus)
Aves PM5 35
  • 77.23 (n)
  • 87.14 (a)
-- 36
  • 86 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nomo3 35
  • 72.13 (n)
  • 79.9 (a)
(Danio rerio)
Actinopterygii nomo 35
  • 66.69 (n)
  • 70.85 (a)
nomo 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005856 35
  • 45.16 (n)
  • 35.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1371 35
  • 46.05 (n)
  • 34.28 (a)
CG1371 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea nra-4 35
  • 43.06 (n)
  • 27.77 (a)
nra-4 36
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62360 35
  • 45.03 (n)
  • 34.26 (a)
(Oryza sativa)
Liliopsida Os01g0300600 35
  • 45.37 (n)
  • 39.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4870 36
  • 37 (a)
Species with no ortholog for NOMO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOMO3 Gene

Gene Tree for NOMO3 (if available)
Gene Tree for NOMO3 (if available)

Paralogs for NOMO3 Gene

Paralogs for NOMO3 Gene

genes like me logo Genes that share paralogs with NOMO3: view

Variants for NOMO3 Gene

Sequence variations from dbSNP and Humsavar for NOMO3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3891245 -- 16,254,430(+) ATCAA(G/T)AAGGA intron-variant
rs13330591 -- 16,234,565(+) AGAAA(C/T)AATCA intron-variant
rs367313 -- 16,267,497(+) tggct(C/T)gatct intron-variant
rs373190 -- 16,269,098(+) GACAT(C/G)TCCTC intron-variant
rs373369 -- 16,263,834(+) TGACC(A/G)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOMO3 Gene

Variant ID Type Subtype PubMed ID
nsv435664 CNV Deletion 17901297
esv2714015 CNV Deletion 23290073
nsv457428 CNV Gain 19166990
dgv2616n71 CNV Gain 21882294
dgv816e1 CNV Complex 17122850
dgv817e1 CNV Complex 17122850
nsv905415 CNV Gain 21882294
nsv469785 CNV Complex 16826518
esv33614 CNV Gain+Loss 17666407
nsv905424 CNV Gain 21882294
nsv428319 CNV Loss 18775914
nsv905425 CNV Gain 21882294
dgv818e1 CNV Complex 17122850
nsv509599 CNV Insertion 20534489
nsv9362 CNV Loss 18304495
nsv9363 CNV Loss 18304495
esv28069 CNV Gain+Loss 19812545

Variation tolerance for NOMO3 Gene

Gene Damage Index Score: 6.33; 76.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NOMO3 Gene

Disorders for NOMO3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NOMO3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pseudoxanthoma elasticum
  • pseudoxanthoma elasticum, modifier of severity of
superficial urinary bladder cancer
  • superficial urinary bladder carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NOMO3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOMO3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NOMO3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOMO3 Gene

Publications for NOMO3 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 67
  2. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PMID: 15257293) Haffner C. … Haass C. (EMBO J. 2004) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3

Products for NOMO3 Gene

Sources for NOMO3 Gene