NOMO2 Gene
protein-coding GIFtS: 46
GCID: GC16M018511
|
|
NODAL modulator 2
| |
Aliases
for NOMO2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NODAL Modulator 21 2 | | PM51 2 | | PM5 Protein 22 3 | | NOMO1 | | Nomo2 | | PM5 Protein, Centromeric Copy2 |
Export aliases for NOMO2 gene to outside databasesPrevious GC identifer: GC16M018419 |
Summaries
for NOMO2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NOMO2:
This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of threehighly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encodeclosely related proteins that may have the same function. The protein encoded by one of these genes has beenidentified as part of a protein complex that participates in the Nodal signaling pathway during vertebratedevelopment. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated withpseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: NOMO2_HUMAN, Q5JPE7Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning,via its interaction with NCLN (By similarity)
|
Genomic Views
for NOMO2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOMO2 gene promoter:
Elk-1 p53 Sp1 AML1a Pax-6 Lmo2 GATA-1 AREB6 MZF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOMO2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOMO2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.3 Ensembl cytogenetic band: 16p12.3 HGNC cytogenetic band: 16p12.3NOMO2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M018511: view genomic region
(about GC identifiers)
Start:
|
18,511,182 bp from pter |
End:
|
18,573,533 bp from pter |
Size:
|
62,352 bases |
Orientation:
|
minus strand |
|
Proteins
for NOMO2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOMO2_HUMAN, Q5JPE7 (See
protein sequence)Recommended Name: Nodal modulator 2 precursor Size: 1267 amino acids; 139439 Da
Subunit: Forms a complex with NCLN and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwisequickly degraded by the proteasome
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
Caution: There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1 (AC Q15155), NOMO2 and NOMO3 (AC P69849).All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probablydo not discriminate between the different members. The results reported in other entries may therefore apply for thisproteinAlternative splicing: 2 isoforms: Q5JPE7-1 Q5JPE7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NOMO2: NX_Q5JPE7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5JPE7
NOMO2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001004060.1 NP_775885.1
ENSEMBL proteins: ENSP00000331851 ENSP00000370883 ENSP00000457351 ENSP00000454780 ENSP00000455456 ENSP00000454412 ENSP00000439970
Human Recombinant Protein Products for NOMO2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NOMO2 for ontologies About GeneDecksing
NOMO2 Antibody Products:
Assay Products for NOMO2: |
Protein
Domains /
Families
for NOMO2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOMO2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5JPE7ProtoNet protein and cluster: Q5JPE7 1 Blocks protein family: IPB008454 Cna B-type
|
Function
for NOMO2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NOMO2_HUMAN, Q5JPE7Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning,via its interaction with NCLN (By similarity) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
NOMO2 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO2 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO2 |
|
Pathways & Interactions
for NOMO2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOMO2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/9 Interacting proteins for NOMO2 (Q5JPE72, 3 ENSP000003708834) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for NOMO2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NOMO2
Search CenterWatch for drugs/clinical trials and news about NOMO2
|
Transcripts
for NOMO2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOMO2 gene (2 alternative transcripts): NM_001004060.1 NM_173614.2 Unigene Cluster for NOMO2: NODAL modulator 2 Hs.460141 [show with all ESTs]Unigene Representative Sequence: NM_0010040679 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000330537(uc002dfe.3 uc002dff.3 uc010bvx.3) ENST00000381474
ENST00000564991 ENST00000569526 ENST00000567831 ENST00000569051 ENST00000564355
ENST00000562312 ENST00000543392
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Additional cDNA sequence: AK225803.1 AL832855.1 BC006531.2 BC013837.1 BC028389.1 BC041131.1 24/47 DOTS entries (see all 47): DT.95134048 DT.102844108 DT.87007895 DT.95134002 DT.120662325 DT.95259277 DT.95134076 DT.91807378 DT.92467676 DT.100715957 DT.40255264 DT.120707660 DT.100045081 DT.120662294 DT.206108 DT.95260676 DT.120662261 DT.120662273 DT.120705601 DT.120705603 DT.120705787 DT.75137441 DT.95298397 DT.95352835 24/542 AceView cDNA sequences (see all 542): AI914152 BX439591 BI914266 BQ961970 AA422091 BU608904 CF131838 BG328788 AA830022 AL557295 AW019970 BU634378 BQ649748 BM556320 BM810829 BQ218916 CK000995 BE311772 BQ053512 BU166057 AJ713315 BE313899 CD359121 BC065535
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NOMO2 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22a | · | 22b | ^ | 23 |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for NOMO2
|
Expression
for NOMO2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOMO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NOMO2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOMO2
SOURCE GeneReport for Unigene cluster: Hs.460141
UniProtKB/Swiss-Prot: NOMO2_HUMAN, Q5JPE7Tissue specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart
SABiosciences Custom PCR Arrays for NOMO2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOMO2
Browse OriGene validated miRNA SYBR primer pairs
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Primer Assays in human, mouse, rat NOMO2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOMO2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOMO2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO2 |
Orthologs
for NOMO2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NOMO2 gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for NOMO2 (if available)
TreeFam Gene Tree for NOMO2 (if available) |
Paralogs
for NOMO2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NOMO2 gene
- NOMO31 2 NOMO11 2
3 SIMAP similar genes for NOMO2 using alignment to 6 protein entries: NOMO2_HUMAN (see all proteins):DKFZp547A1913 NOMO1 NOMO3
NOMO2 for paralogs About GeneDecksing
|
Genomic Variants
for NOMO2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NOMO2 (18511182 - 18573533 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for NOMO2
9 CNVs: 4930 72493 30754 3994 32092 8814 3112 8816 87989 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOMO2 |
|
Disorders
/ Diseases
for NOMO2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 NOMO2 for disorders About MalaCards
NOMO2 for disorders About GeneDecksing
OMIM gene information: 609158
OMIM disorders: --
Export disorders for NOMO2 gene to outside databases
|
Publications
for NOMO2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOMO2 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with NOMO2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PubMed id 15257293)1, 2, 3 Haffner C....Haass C. (2004)
- The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. (PubMed id 17261586)1, 2 Haffner C.... Haass C. (2007)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for NOMO2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NOMO2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOMO2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOMO2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOMO2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NOMO2 gene:
Search GeneIP for patents involving NOMO2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOMO2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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