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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOMO2 Gene

protein-coding   GIFtS: 45
GCID: GC16M018511

NODAL Modulator 2

  Search for NOMO2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NODAL Modulator 21 2
PM5 Protein 22 3
Nomo2
PM52
PM5 Protein, Centromeric Copy2

External Ids:    HGNC: 226521   Entrez Gene: 2838202   Ensembl: ENSG000001851647   OMIM: 6091585   UniProtKB: Q5JPE73   

Export aliases for NOMO2 gene to outside databases

Previous GC identifer: GC16M018419


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOMO2 Gene:
This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of
three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes
encode closely related proteins that may have the same function. The protein encoded by one of these genes has
been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate
development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with
pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NOMO2 Gene: 
NOMO2 (NODAL modulator 2) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding and carboxypeptidase activity. An important paralog of this gene is NOMO1.

UniProtKB/Swiss-Prot: NOMO2_HUMAN, Q5JPE7
Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal
patterning, via its interaction with NCLN (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOMO2 gene promoter:
         Elk-1   p53   Sp1   AML1a   Pax-6   Lmo2   GATA-1   AREB6   MZF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOMO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOMO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOMO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

NOMO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOMO2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M018511:  view genomic region     (about GC identifiers)

Start:
18,511,182 bp from pter      End:
18,573,533 bp from pter
Size:
62,352 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOMO2_HUMAN, Q5JPE7 (See protein sequence)
Recommended Name: Nodal modulator 2 precursor  
Size: 1267 amino acids; 139439 Da
Subunit: Forms a complex with NCLN and TMEM147, resulting in a stabilization of the 3 proteins, which are
otherwise quickly degraded by the proteasome
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
Caution: There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1 (AC Q15155), NOMO2 and NOMO3 (AC
P69849). All 3 are extremely similar, which makes their individual characterization difficult. Thus, most
experiments probably do not discriminate between the different members. The results reported in other entries may
therefore apply for this protein
Alternative splicing: 2 isoforms:  Q5JPE7-1   Q5JPE7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOMO2: NX_Q5JPE7

Explore proteomics data for NOMO2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5JPE7

  • NOMO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOMO2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001004060.1  NP_775885.1  

    ENSEMBL proteins: 
     ENSP00000331851   ENSP00000370883   ENSP00000457351   ENSP00000454780   ENSP00000455456  
     ENSP00000454412   ENSP00000439970  

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    Cloud-Clone Corp. Proteins for NOMO2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA17261586
    GO:0016021integral to membrane IEA--

    NOMO2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR013784 Carb-bd-like_fold
     IPR008969 CarboxyPept-like_regulatory
     IPR013783 Ig-like_fold
     IPR014766 CarboxyPept_regulatory_dom
     IPR027064 NOMO

    Graphical View of Domain Structure for InterPro Entry Q5JPE7

    ProtoNet protein and cluster: Q5JPE7

    1 Blocks protein domain: IPB008454 Cna B-type


    NOMO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOMO2_HUMAN, Q5JPE7
    Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal
    patterning, via its interaction with NCLN (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17261586
    GO:0030246carbohydrate binding IEA--
         
    NOMO2 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOMO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for NOMO2 (Q5JPE72, 3 ENSP000003708834) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE3AQ050862, 3, ENSP000003810454MINT-8276439 I2D: score=2 STRING: ENSP00000381045
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    APCP250543I2D: score=1 
    ETS1P149213I2D: score=1 
    EXOSC10ENSP000003661354STRING: ENSP00000366135
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOMO2

    Search CenterWatch for drugs/clinical trials and news about NOMO2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOMO2 gene (2 alternative transcripts): 
    NM_001004060.1  NM_173614.2  

    Unigene Cluster for NOMO2:

    NODAL modulator 2
    Hs.460141  [show with all ESTs]
    Unigene Representative Sequence: NM_001004067
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330537(uc002dfe.3 uc002dff.3 uc010bvx.3) ENST00000381474
    ENST00000564991 ENST00000569526 ENST00000567831 ENST00000569051 ENST00000564355
    ENST00000562312 ENST00000543392
    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate NOMO2:
    hsa-miR-4291 hsa-miR-922 hsa-miR-759 hsa-miR-33a hsa-miR-214 hsa-miR-542-3p hsa-miR-33b hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AK225803.1 AL832855.1 BC006531.2 BC013837.1 BC028389.1 BC041131.1 

    24/47 DOTS entries (see all 47):

    DT.95134048  DT.102844108  DT.87007895  DT.95134002  DT.120662325  DT.95259277  DT.95134076  DT.91807378 
    DT.92467676  DT.100715957  DT.40255264  DT.120707660  DT.100045081  DT.120662294  DT.206108  DT.95260676 
    DT.120662261  DT.120662273  DT.120705601  DT.120705603  DT.120705787  DT.75137441  DT.95298397  DT.95352835 

    24/542 AceView cDNA sequences (see all 542):

    BM665975 BF981520 BQ227868 BG482249 BG680698 AA307008 BE740863 CN483130 
    BG742879 NM_014287 AI572588 BU501263 AW851457 BQ219954 CF135225 BM721646 
    F02563 BQ222753 BM710887 BX951904 BU557334 CK000997 T98827 BF724868 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NOMO2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                -                                                                           

    ExUns: 22a · 22b ^ 23
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for NOMO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOMO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NOMO2 Expression
    About this image


    See NOMO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOMO2

    SOURCE GeneReport for Unigene cluster: Hs.460141

    UniProtKB/Swiss-Prot: NOMO2_HUMAN, Q5JPE7
    Tissue specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOMO2 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nomo11 nodal modulator 1 86.32(n)
    93.28(a)
      211548  NM_153057.4  NP_694697.3 
    chicken
    (Gallus gallus)
    Aves PM51 pM5 protein 77.18(n)
    87.22(a)
      416602  XM_414903.3  XP_414903.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    86(a)
    1 → many
    GL343580.1(301242-312387)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48372 Xenopus laevis transcribed sequence with moderate similarity more 73.66(n)    CB208340.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nomo1 nodal modulator 66.67(n)
    70.94(a)
      446115  XM_002662315.1  XP_002662361.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13711 CG1371 45.97(n)
    34.04(a)
      36053  NM_136707.2  NP_610551.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nra-41 Protein NRA-4 42.97(n)
    27.99(a)
      3565008  NM_070966.2  NP_503367.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G623601 carbohydrate-binding-like fold-containing protein 45.15(n)
    34.54(a)
      825409  NM_116101.3  NP_191795.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g03006001 hypothetical protein 45.37(n)
    39.65(a)
      4325779  NM_001049353.1  NP_001042818.2 


    ENSEMBL Gene Tree for NOMO2 (if available)
    TreeFam Gene Tree for NOMO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOMO2 gene
    NOMO31 2  NOMO11 2  
    3 SIMAP similar genes for NOMO2 using alignment to 6 protein entries:     NOMO2_HUMAN (see all proteins):
    DKFZp547A1913    NOMO1    NOMO3

    NOMO2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/318 SNPs in NOMO2 are shown (see all 318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0341384
    ----see VAR_0341382 D N mis40--------
    VAR_0341404
    ----see VAR_0341402 N K mis40--------
    VAR_0161044
    ----see VAR_0161042 V M mis40--------
    VAR_0341394
    ----see VAR_0341392 V M mis40--------
    rs2018835611,2
    C--18518154(+) GGTGAA/TGTGTT 4 I F mis10--------
    rs2011909951,2
    --18518281(+) TTTTAC/TAAGGA 2 -- int10--------
    rs2003072371,2
    --18525621(+) CACAGG/TATGAA 2 -- int10--------
    rs1378625091,2
    C--18531692(+) TTCATC/TCATCC 2 -- int10--------
    rs1494585791,2
    C--18531727(+) ATCCAC/TCCAAC 2 -- int10--------
    rs2010367411,2
    C--18532017(+) TAATAC/TACTTC 2 -- int10--------

    HapMap Linkage Disequilibrium report for NOMO2 (18511182 - 18573533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for NOMO2 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2421404CNV Deletion20811451
    nsv509601CNV Insertion20534489
    nsv428320CNV Loss18775914
    dgv2637n71CNV Loss21882294
    dgv2636n71CNV Loss21882294
    dgv2633n71CNV Gain21882294
    nsv833160CNV Gain17160897
    esv2751550CNV Gain17911159
    nsv905536CNV Gain21882294
    nsv905537CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NOMO2 for disorders           About MalaCards
    OMIM gene information: 609158    OMIM disorders: --


    NOMO2 for disorders           About GeneDecksing


    Export disorders for NOMO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOMO2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with NOMO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PubMed id 15257293)1, 2, 3 Haffner C....Haass C. (2004)
    2. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. (PubMed id 17261586)1, 2 Haffner C.... Haass C. (2007)
    3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283820 HGNC: 22652 AceView: NOMO1 Ensembl:ENSG00000185164 euGenes: HUgn283820
    ECgene: NOMO2 H-InvDB: NOMO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOMO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOMO2 gene:
    Search GeneIP for patents involving NOMO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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