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Aliases for NOMO2 Gene

Aliases for NOMO2 Gene

  • NODAL Modulator 2 2 3
  • PM5 Protein 2 3 4
  • PM5 Protein, Centromeric Copy 3
  • Nomo 3
  • PM5 3

External Ids for NOMO2 Gene

Previous GeneCards Identifiers for NOMO2 Gene

  • GC16M018419
  • GC16M018511

Summaries for NOMO2 Gene

Entrez Gene Summary for NOMO2 Gene

  • This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOMO2 Gene

NOMO2 (NODAL Modulator 2) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is NOMO1.

UniProtKB/Swiss-Prot for NOMO2 Gene

  • May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOMO2 Gene

Genomics for NOMO2 Gene

Regulatory Elements for NOMO2 Gene

Genomic Location for NOMO2 Gene

18,417,325 bp from pter
18,562,211 bp from pter
144,887 bases
Minus strand

Genomic View for NOMO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOMO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOMO2 Gene

Proteins for NOMO2 Gene

  • Protein details for NOMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nodal modulator 2
    Protein Accession:
    Secondary Accessions:
    • Q4G177

    Protein attributes for NOMO2 Gene

    1267 amino acids
    Molecular mass:
    139439 Da
    Quaternary structure:
    • Forms a complex with NCLN and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome

    Alternative splice isoforms for NOMO2 Gene


neXtProt entry for NOMO2 Gene

Proteomics data for NOMO2 Gene at MOPED

Post-translational modifications for NOMO2 Gene

  • Ubiquitination at Lys134, Lys138, Lys159, Lys170, Lys175, Lys193, Lys356, Lys630, Lys770, Lys927, Lys1019, and Lys1079
  • Glycosylation at Asn50, Asn218, Asn369, and Asn618
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NOMO2 Gene

Domains for NOMO2 Gene

Protein Domains for NOMO2 Gene

Suggested Antigen Peptide Sequences for NOMO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOMO2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOMO2 Gene

Function for NOMO2 Gene

Molecular function for NOMO2 Gene

UniProtKB/Swiss-Prot Function:
May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN.

Gene Ontology (GO) - Molecular Function for NOMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17261586
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with NOMO2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NOMO2 Gene

Localization for NOMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOMO2 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NOMO2 Gene COMPARTMENTS Subcellular localization image for NOMO2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NOMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 17261586
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NOMO2: view

Pathways for NOMO2 Gene

SuperPathways for NOMO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOMO2 Gene


No data available for Pathways by source for NOMO2 Gene

Transcripts for NOMO2 Gene

Unigene Clusters for NOMO2 Gene

NODAL modulator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOMO2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOMO2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP5: -

ExUns: 22a · 22b ^ 23

Relevant External Links for NOMO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOMO2 Gene

mRNA expression in normal human tissues for NOMO2 Gene

Protein differential expression in normal tissues for NOMO2 Gene

This gene is overexpressed in Heart (19.9), Peripheral blood mononuclear cells (17.0), Brain (15.3), Placenta (9.3), and Pancreatic juice (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NOMO2 Gene

SOURCE GeneReport for Unigene cluster for NOMO2 Gene Hs.460141

mRNA Expression by UniProt/SwissProt for NOMO2 Gene

Tissue specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
genes like me logo Genes that share expressions with NOMO2: view

Expression partners for NOMO2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NOMO2 Gene

Orthologs for NOMO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOMO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOMO1 35
  • 88.45 (n)
  • 94.83 (a)
-- 36
  • 95 (a)
(Canis familiaris)
Mammalia NOMO1 35
  • 89.97 (n)
  • 95.97 (a)
-- 36
  • 95 (a)
(Mus musculus)
Mammalia Nomo1 35
  • 86.32 (n)
  • 93.28 (a)
Nomo1 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Nomo1 35
  • 86.82 (n)
  • 93.69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
(Gallus gallus)
Aves PM5 35
  • 77.23 (n)
  • 87.14 (a)
-- 36
  • 86 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nomo3 35
  • 72.02 (n)
  • 79.9 (a)
Str.1592 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4837 35
(Danio rerio)
Actinopterygii nomo 35
  • 66.67 (n)
  • 70.94 (a)
nomo 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005856 35
  • 45.18 (n)
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1371 35
  • 46.02 (n)
  • 34.21 (a)
CG1371 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea nra-4 35
  • 42.93 (n)
  • 27.68 (a)
nra-4 36
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62360 35
  • 44.96 (n)
  • 34.26 (a)
(Oryza sativa)
Liliopsida Os01g0300600 35
  • 45.37 (n)
  • 39.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7168 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4870 36
  • 37 (a)
Species with no ortholog for NOMO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOMO2 Gene

Gene Tree for NOMO2 (if available)
Gene Tree for NOMO2 (if available)

Paralogs for NOMO2 Gene

Paralogs for NOMO2 Gene

(3) SIMAP similar genes for NOMO2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NOMO2: view

Variants for NOMO2 Gene

Sequence variations from dbSNP and Humsavar for NOMO2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs534647460 -- 18,528,692(+) GCTCA(A/C)GCCTG intron-variant
rs534832276 -- 18,548,010(+) TGACA(A/C)ATGAG intron-variant
rs534894602 -- 18,560,203(+) CCAGT(A/G)TGAAA intron-variant
rs534967067 -- 18,534,407(+) TGTGG(C/T)GTCCA intron-variant
rs535014827 -- 18,520,913(+) CTGCT(G/T)CTCCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for NOMO2 Gene

Variant ID Type Subtype PubMed ID
nsv7278 OTHER Inversion 18451855
esv2751550 CNV Gain 17911159
esv587 CNV CNV 17122850
dgv822e1 CNV Complex 17122850
dgv823e1 CNV Complex 17122850
dgv2633n71 CNV Gain 21882294
nsv428320 CNV Loss 18775914
nsv905522 CNV Gain 21882294
dgv824e1 CNV Complex 17122850
esv34419 CNV Gain 17911159
nsv905536 CNV Gain 21882294
nsv509601 CNV Insertion 20534489
nsv905537 CNV Gain 21882294
esv28183 CNV Gain+Loss 19812545
nsv833160 CNV Gain 17160897
nsv9378 CNV Gain+Loss 18304495
esv990950 CNV Gain 20482838
essv8865 CNV CNV 17122850
dgv825e1 CNV Complex 17122850
nsv9379 CNV Gain 18304495
dgv2636n71 CNV Loss 21882294
dgv2637n71 CNV Loss 21882294
esv2421404 CNV Deletion 20811451

Relevant External Links for NOMO2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOMO2 Gene

Disorders for NOMO2 Gene

No disorders were found for NOMO2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NOMO2 Gene

Publications for NOMO2 Gene

  1. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PMID: 15257293) Haffner C. … Haass C. (EMBO J. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  4. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. (PMID: 17261586) Haffner C. … Haass C. (J. Biol. Chem. 2007) 3 4
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for NOMO2 Gene

Sources for NOMO2 Gene

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