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NOMO1 Gene

protein-coding   GIFtS: 49
GCID: GC16P014927

NODAL Modulator 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NODAL Modulator 11 2     PM5 Protein 32
PM52 3     PM5 Protein, Telomeric Copy2
Nomo2     PM5 Protein3
Nodal Modulator 32     

External Ids:    HGNC: 300601   Entrez Gene: 234202   Ensembl: ENSG000001035127   OMIM: 6091575   UniProtKB: Q151553   

Export aliases for NOMO1 gene to outside databases

Previous GC identifers: GC16P014836 GC16P014730


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOMO1 Gene:
This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of
three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes
encode closely related proteins that may have the same function. The protein encoded by one of these genes has
been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate
development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with
pseudoxanthoma elasticum (PXE). (provided by RefSeq, Jul 2008)

GeneCards Summary for NOMO1 Gene:
NOMO1 (NODAL modulator 1) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is NOMO2.

UniProtKB/Swiss-Prot: NOMO1_HUMAN, Q15155
Function: May antagonize Nodal signaling (By similarity)

Gene Wiki entry for NOMO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NOMO1 gene promoter:
         p53   Sp1   AML1a   Pax-6   Lmo2   LCR-F1   GATA-1   AREB6   MZF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOMO1 promoter sequence
   Search Chromatin IP Primers for NOMO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOMO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.11   Ensembl cytogenetic band:  16p13.11   HGNC cytogenetic band: 16p13.11

NOMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOMO1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P014927:  view genomic region     (about GC identifiers)

Start:
14,927,538 bp from pter      End:
14,990,017 bp from pter
Size:
62,480 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NOMO1_HUMAN, Q15155 (See protein sequence)
Recommended Name: Nodal modulator 1 precursor  
Size: 1222 amino acids; 134324 Da
Developmental stage: No difference between normal colonic mucosa and colon tumor tissue in mRNA expression,
whereas the protein is expressed 1.5-fold more in normal colonic mucosa that in colon tumor tissue
Caution: There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1, NOMO2 (AC Q5JPE7) and NOMO3 (AC
P69849). All 3 are extremely similar, which makes their individual characterization difficult. Thus, most
experiments probably do not discriminate between the different members. Moreover, it does not allow a clear view
of which variant belongs to which of the 3 copies. The results reported in other entries may therefore apply for
this protein
Secondary accessions: P78421 Q8IW21 Q96DG0

Explore the universe of human proteins at neXtProt for NOMO1: NX_Q15155

Explore proteomics data for NOMO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys134, Lys138, Lys159, Lys170, Lys175, Lys193, Lys356, Lys630, Lys770, Lys927,
                                 Lys1019, Lys1079
  • Glycosylation2 at Asn50, Asn218, Asn369, Asn618
  • Modification sites at PhosphoSitePlus

  • See NOMO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055102.3  
    ENSEMBL proteins: 
     ENSP00000287667   ENSP00000457581  

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    antibodies-online peptides for NOMO1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR008969 CarboxyPept-like_regulatory
     IPR013783 Ig-like_fold
     IPR013784 Carb-bd-like_fold
     IPR014766 CarboxyPept_regulatory_dom

    Graphical View of Domain Structure for InterPro Entry Q15155

    ProtoNet protein and cluster: Q15155

    1 Blocks protein domain: IPB008454 Cna B-type


    Find genes that share domains with NOMO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOMO1_HUMAN, Q15155
    Function: May antagonize Nodal signaling (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with NOMO1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NOMO1

    miRNA
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    miRTarBase miRNAs that target NOMO1:
    hsa-mir-10a-5p (MIRT047692)

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    6 qRT-PCR Assays for microRNAs that regulate NOMO1:
    hsa-miR-4291 hsa-miR-214 hsa-miR-922 hsa-miR-518a-5p hsa-miR-542-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidNOMO1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOMO1_HUMAN, Q15155: Membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with NOMO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOMO1
    Interactions:

        Search GeneGlobe Interaction Network for NOMO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOMO1 (Q151552, 3 ENSP000002876674) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-64227 I2D: score=5 
    ENSG00000096155P463792, 3MINT-64227 I2D: score=5 
    ENSG00000227761P463792, 3MINT-64227 I2D: score=5 
    ENSG00000228760P463792, 3MINT-64227 I2D: score=5 
    ENSG00000229524P463792, 3MINT-64227 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with NOMO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOMO1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOMO1 gene: 
    NM_014287.3  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287667(uc002dcv.3) ENST00000566720 ENST00000566883 ENST00000566917
    ENST00000565655 ENST00000566823
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate NOMO1:
    hsa-miR-4291 hsa-miR-214 hsa-miR-922 hsa-miR-518a-5p hsa-miR-542-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidNOMO1 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOMO1
      QuantiTect SYBR Green Assays in human, mouse, rat NOMO1
      QuantiFast Probe-based Assays in human, mouse, rat NOMO1

    Selected AceView cDNA sequences (see all 542):

    BQ961655 BE744305 AA191302 CD105265 BE311746 BM665975 BF981520 BQ227868 
    BG482249 BG680698 AA307008 BE740863 CN483130 BG742879 NM_014287 AI572588 
    BU501263 AW851457 BQ219954 CF135225 BM721646 F02563 BQ222753 BM710887 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOMO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NOMO1 Expression
    About this image


    NOMO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Olfactory Bulb   
    NOMO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOMO1 Protein Expression

    UniProtKB/Swiss-Prot: NOMO1_HUMAN, Q15155
    Tissue specificity: Expressed in colon tumor tissue and in adjacent normal colonic mucosa

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOMO1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nomo11 , 5 nodal modulator 11, 5 86.32(n)1
    93.45(a)1
      7 (29.66 cM)5
    2115481  NM_153057.41  NP_694697.31 
     460336985 
    chicken
    (Gallus gallus)
    Aves PM51 pM5 protein 77.17(n)
    87.14(a)
      416602  XM_004945285.1  XP_004945342.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    87(a)
    1 → many
    GL343580.1(301242-312387)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nomo31 NODAL modulator 3 72.02(n)
    79.98(a)
      100158535  NM_001127971.1  NP_001121443.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nomo1 nodal modulator 66.67(n)
    70.85(a)
      446115  XM_002662315.2  XP_002662361.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13711 CG1371 45.94(n)
    34.01(a)
      36053  NM_136707.2  NP_610551.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nra-41 nra-4 43.03(n)
    27.68(a)
      3565008  NM_070966.3  NP_503367.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G623601 AT3G62360 45.06(n)
    34.26(a)
      825409  NM_116101.3  NP_191795.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g03006001 Os01g0300600 45.08(n)
    39.65(a)
      4325779  NM_001049353.1  NP_001042818.2 


    ENSEMBL Gene Tree for NOMO1 (if available)
    TreeFam Gene Tree for NOMO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOMO1 gene
    NOMO31 2  NOMO21 2  
    3 SIMAP similar genes for NOMO1 using alignment to 2 protein entries:     NOMO1_HUMAN (see all proteins):
    DKFZp547A1913    NOMO2    NOMO3

    Find genes that share paralogs with NOMO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOMO1 (see all 554)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2003450721,2
    C--14926075(+) AATAAA/GTAGAC 1 -- us2k10--------
    rs28565041,2
    --14926853(+) GTTTTC/TAGGCA 1 -- us2k10--------
    rs18172391,2
    --14927024(-) TAAGCA/GAAACG 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs13792051,2
    F,A--14927081(-) CTTTAA/GGAATT 1 -- us2k11Minor allele frequency- G:0.18MN 184
    rs1448848561,2
    C--14927107(+) TTTTC-/GTGTGTG 1 -- us2k10--------
    rs3725018021,2
    C--14927108(+) TTTTT-/GTTGTGT 1 -- us2k10--------
    rs1843243181,2
    --14927442(+) CCTTGA/CGTTGC 1 -- us2k10--------
    rs1403418581,2
    --14927448(+) GTTGCA/GCCTGC 1 -- us2k10--------
    rs1887574361,2
    --14927450(+) TGCGCC/GTGCCA 1 -- us2k10--------
    rs1812404331,2
    --14927451(+) GCGCCG/TGCCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NOMO1 (14927538 - 14990017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NOMO1 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714012CNV Deletion23290073
    esv2714013CNV Deletion23290073
    nsv471383CNV Duplication19718026
    nsv509597CNV Insertion20534489
    nsv103370CNV Loss16902084
    nsv905362CNV Loss21882294
    nsv433435CNV Gain18776910
    nsv905356CNV Gain21882294
    esv32598CNV Gain17666407
    esv994412CNV Gain20482838

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NOMO1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609157    OMIM disorders: --


    Find genes that share disorders with NOMO1           About GenesLikeMe


    Export disorders for NOMO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOMO1 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with NOMO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family. (PubMed id 1310294)1, 2, 3 Templeton N.S.... Stetler-Stevenson W.G. (Genomics 1992)
    2. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    3. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PubMed id 15257293)1, 3 Haffner C.... Haass C. (EMBO J. 2004)
    4. Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. (PubMed id 11139250)2, 9 Perdu J. and Germain D.P. (Hum. Mutat. 2001)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1). (PubMed id 22832245)1 Gao W.L....Wang Y.L. (RNA Biol 2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23420 HGNC: 30060 AceView: NOMO1 Ensembl:ENSG00000103512 euGenes: HUgn23420
    ECgene: NOMO1 H-InvDB: NOMO1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NOMO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOMO1 gene:
    Search GeneIP for patents involving NOMO1

    GeneCards and IP:
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