NOMO1 Gene
protein-coding GIFtS: 50
GCID: GC16P014927
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NODAL modulator 1
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Aliases
for NOMO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NODAL Modulator 11 2 | | PM5 Protein 32 | | PM51 2 3 | | PM5 Protein, Telomeric Copy2 | | Nomo2 | | PM5 Protein3 | | Nodal Modulator 32 | | |
Export aliases for NOMO1 gene to outside databasesPrevious GC identifers: GC16P014836 GC16P014730 |
Summaries
for NOMO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NOMO1:
This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of threehighly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encodeclosely related proteins that may have the same function. The protein encoded by one of these genes has beenidentified as part of a protein complex that participates in the Nodal signaling pathway during vertebratedevelopment. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated withpseudoxanthoma elasticum (PXE). (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NOMO1_HUMAN, Q15155Function: May antagonize Nodal signaling (By similarity)
Gene Wiki entry for NOMO1
|
Genomic Views
for NOMO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOMO1 gene promoter:
p53 Sp1 AML1a Pax-6 Lmo2 LCR-F1 GATA-1 AREB6 MZF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOMO1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOMO1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.11 Ensembl cytogenetic band: 16p13.11 HGNC cytogenetic band: 16p13.11NOMO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P014927: view genomic region
(about GC identifiers)
Start:
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14,927,538 bp from pter |
End:
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14,990,017 bp from pter |
Size:
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62,480 bases |
Orientation:
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plus strand |
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Proteins
for NOMO1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOMO1_HUMAN, Q15155 (See
protein sequence)Recommended Name: Nodal modulator 1 precursor Size: 1222 amino acids; 134324 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Developmental stage: No difference between normal colonic mucosa and colon tumor tissue in mRNA expression, whereas theprotein is expressed 1.5-fold more in normal colonic mucosa that in colon tumor tissue
Caution: There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1, NOMO2 (AC Q5JPE7) and NOMO3 (AC P69849).All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probablydo not discriminate between the different members. Moreover, it does not allow a clear view of which variant belongsto which of the 3 copies. The results reported in other entries may therefore apply for this protein
Secondary accessions: P78421 Q8IW21 Q96DG0Explore the universe of human proteins at neXtProt for NOMO1: NX_Q15155
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15155
NOMO1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055102.3
ENSEMBL proteins: ENSP00000287667 ENSP00000457581
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
NOMO1 for ontologies About GeneDecksing
NOMO1 Antibody Products:
Assay Products for NOMO1: |
Protein
Domains /
Families
for NOMO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOMO1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15155ProtoNet protein and cluster: Q15155 1 Blocks protein family: IPB008454 Cna B-type
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Function
for NOMO1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NOMO1_HUMAN, Q15155Function: May antagonize Nodal signaling (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0004180 | carboxypeptidase activity |
IEA | -- | | GO:0030246 | carbohydrate binding |
IEA | -- |
NOMO1 for ontologies About GeneDecksing
|
Pathways & Interactions
for NOMO1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOMO1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/13 Interacting proteins for NOMO1 (Q151552, 3 ENSP000002876674) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
NOMO1 for ontologies About GeneDecksing
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Drugs & Compounds
for NOMO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NOMO1
Search CenterWatch for drugs/clinical trials and news about NOMO1
|
Transcripts
for NOMO1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOMO1 gene: NM_014287.3 Unigene Cluster for NOMO1: NODAL modulator 1 Hs.743963 [show with all ESTs]Unigene Representative Sequence: NM_0142876 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000287667(uc002dcv.3) ENST00000566720 ENST00000566883 ENST00000566917
ENST00000565655 ENST00000566823
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOMO1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NOMO1 (NM_014287) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOMO1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOMO1 |
Additional cDNA sequence: AK125530.1 BC065535.1 X57398.1 24/37 DOTS entries (see all 37): DT.95259277 DT.40255264 DT.100715957 DT.95134048 DT.95134002 DT.120662325 DT.87007895 DT.102844108 DT.100705818 DT.120707602 DT.91807378 DT.92467676 DT.100650340 DT.95134076 DT.100045081 DT.120705603 DT.85105030 DT.95128743 DT.95298397 DT.120662257 DT.120705599 DT.120705747 DT.120707580 DT.95134003 24/542 AceView cDNA sequences (see all 542): AI914152 BX439591 BI914266 BQ961970 AA422091 CF131838 BU608904 BG328788 BU634378 AW019970 BQ649748 AA830022 AL557295 BM556320 BQ218916 BM810829 BE311772 CK000995 BQ053512 BU166057 AJ713315 CD359121 BC065535 BE313899
GeneLoc Exon Structure
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Expression
for NOMO1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOMO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NOMO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOMO1
SOURCE GeneReport for Unigene cluster: Hs.743963
UniProtKB/Swiss-Prot: NOMO1_HUMAN, Q15155Tissue specificity: Expressed in colon tumor tissue and in adjacent normal colonic mucosa
SABiosciences Custom PCR Arrays for NOMO1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOMO1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOMO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOMO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOMO1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO1 |
Orthologs
for NOMO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NOMO1 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for NOMO1 (if available)
TreeFam Gene Tree for NOMO1 (if available) |
Paralogs
for NOMO1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NOMO1 gene
- NOMO31 2 NOMO21 2
3 SIMAP similar genes for NOMO1 using alignment to 2 protein entries: NOMO1_HUMAN (see all proteins):DKFZp547A1913 NOMO2 NOMO3
NOMO1 for paralogs About GeneDecksing
|
Genomic Variants
for NOMO1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NOMO1 (14927538 - 14990017 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for NOMO1
9 CNVs: 3992 32087 77198 87981 72475 7088 37572 37843 87980
1 Inversion: 37175 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for NOMO1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NOMO1 for disorders About GeneDecksing
OMIM gene information: 609157
OMIM disorders: --
2  diseases for NOMO1: About MalaCardsataxia prostatitis
Export disorders for NOMO1 gene to outside databases
|
Publications
for NOMO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOMO1 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with NOMO1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family. (PubMed id 1310294)1, 2, 3 Templeton N.S.... Stetler-Stevenson W.G. (1992)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
- Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PubMed id 15257293)1, 3 Haffner C....Haass C. (2004)
- Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. (PubMed id 11139250)2, 9 Perdu J. and Germain D.P. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
|
External Searches for NOMO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NOMO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOMO1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOMO1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOMO1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NOMO1 gene:
Search GeneIP for patents involving NOMO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOMO1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOMO1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOMO1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOMO1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOMO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOMO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOMO1 |
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| | | | Search Tocris compounds for NOMO1 |
| |  |  |  |  | | | | |
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 | | | NOMO1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOMO1 |
|  |  |  | | | | ThermoFisher Antibodies for NOMO1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOMO1 |
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