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Aliases for NOMO1 Gene

Aliases for NOMO1 Gene

  • NODAL Modulator 1 2 3 5
  • PM5 3 4
  • PM5 Protein, Telomeric Copy 3
  • Nodal Modulator 3 3
  • PM5 Protein 3 3
  • PM5 Protein 4
  • Nomo 3

External Ids for NOMO1 Gene

Previous GeneCards Identifiers for NOMO1 Gene

  • GC16P014836
  • GC16P014927
  • GC16P014730
  • GC16P014871
  • GC16P014872
  • GC16P014873
  • GC16P014874

Summaries for NOMO1 Gene

Entrez Gene Summary for NOMO1 Gene

  • This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). [provided by RefSeq, Jul 2008]

GeneCards Summary for NOMO1 Gene

NOMO1 (NODAL Modulator 1) is a Protein Coding gene. Diseases associated with NOMO1 include Pseudoxanthoma Elasticum and Superficial Urinary Bladder Cancer. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is NOMO3.

UniProtKB/Swiss-Prot for NOMO1 Gene

  • May antagonize Nodal signaling.

Gene Wiki entry for NOMO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOMO1 Gene

Genomics for NOMO1 Gene

Regulatory Elements for NOMO1 Gene

Enhancers for NOMO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F014337 0.6 Ensembl ENCODE 6 -495.8 -495818 1.0 MLX ZFP64 ARID4B YBX1 DMAP1 ZNF48 YY1 YY2 MXD4 MIER2 LOC105371095 ENSG00000263234 ENSG00000270734 MIR193B NOMO1 GC16M014339 GC16P014313
GH16F014362 1.1 Ensembl ENCODE 4.9 -469.3 -469349 3.3 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 SLC30A9 FOS SP5 NFYC NOMO1 NPIPP1 LOC105447648 GC16M014339
GH16F015550 1.3 Ensembl ENCODE 4.1 +717.4 717420 0.6 HDGF MLX ARID4B FEZF1 ZNF2 ZNF48 SLC30A9 ZNF143 FOS ZNF263 C16orf45 MPV17L NOMO1 PIR54531 LOC105371102
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NOMO1 on UCSC Golden Path with GeneCards custom track

Promoters for NOMO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000504231 420 1800 CTCF PKNOX1 ZBTB2 NRF1 SP2 ZBTB8A ZFP69B ZFHX2 ZNF580 ZNF143

Genomic Location for NOMO1 Gene

14,833,681 bp from pter
14,896,160 bp from pter
62,480 bases
Plus strand

Genomic View for NOMO1 Gene

Genes around NOMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOMO1 Gene

Proteins for NOMO1 Gene

  • Protein details for NOMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nodal modulator 1
    Protein Accession:
    Secondary Accessions:
    • P78421
    • Q8IW21
    • Q96DG0

    Protein attributes for NOMO1 Gene

    1222 amino acids
    Molecular mass:
    134324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NOMO1 Gene

Post-translational modifications for NOMO1 Gene

  • Glycosylation at Asn 50, Asn 218, and Asn 618
  • Modification sites at PhosphoSitePlus

Other Protein References for NOMO1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for NOMO1
  • Santa Cruz Biotechnology (SCBT) Antibodies for NOMO1

No data available for DME Specific Peptides for NOMO1 Gene

Domains & Families for NOMO1 Gene

Suggested Antigen Peptide Sequences for NOMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOMO1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOMO1 Gene

Function for NOMO1 Gene

Molecular function for NOMO1 Gene

UniProtKB/Swiss-Prot Function:
May antagonize Nodal signaling.

Gene Ontology (GO) - Molecular Function for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with NOMO1: view

Phenotypes for NOMO1 Gene

genes like me logo Genes that share phenotypes with NOMO1: view

Animal Model Products

miRNA for NOMO1 Gene

miRTarBase miRNAs that target NOMO1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOMO1 Gene

Localization for NOMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOMO1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for NOMO1 Gene COMPARTMENTS Subcellular localization image for NOMO1 gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 2
plasma membrane 2
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NOMO1: view

Pathways & Interactions for NOMO1 Gene

SuperPathways for NOMO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NOMO1: view

No data available for Pathways by source and SIGNOR curated interactions for NOMO1 Gene

Transcripts for NOMO1 Gene

Unigene Clusters for NOMO1 Gene

NODAL modulator 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOMO1 Gene

No ASD Table

Relevant External Links for NOMO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOMO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOMO1 Gene

Protein differential expression in normal tissues from HIPED for NOMO1 Gene

This gene is overexpressed in Pancreas (9.0) and Frontal cortex (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOMO1 Gene

Protein tissue co-expression partners for NOMO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOMO1 Gene:


SOURCE GeneReport for Unigene cluster for NOMO1 Gene:


mRNA Expression by UniProt/SwissProt for NOMO1 Gene:

Tissue specificity: Expressed in colon tumor tissue and in adjacent normal colonic mucosa.
genes like me logo Genes that share expression patterns with NOMO1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NOMO1 Gene

Orthologs for NOMO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOMO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 35
  • 95 (a)
NOMO1 34
  • 88.48 (n)
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
NOMO1 34
  • 90 (n)
(Pan troglodytes)
Mammalia -- 35
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
(Rattus norvegicus)
Mammalia Nomo1 34
  • 86.79 (n)
(Mus musculus)
Mammalia Nomo1 34 35
  • 86.32 (n)
(Gallus gallus)
Aves -- 35
  • 86 (a)
PM5 34
  • 77.17 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nomo3 34
  • 72.02 (n)
(Danio rerio)
Actinopterygii nomo 34 35
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1371 34 35
  • 45.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005856 34
  • 45.36 (n)
(Caenorhabditis elegans)
Secernentea nra-4 34 35
  • 43.03 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62360 34
  • 45.06 (n)
(Oryza sativa)
Liliopsida Os01g0300600 34
  • 45.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4870 35
  • 37 (a)
Species where no ortholog for NOMO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOMO1 Gene

Gene Tree for NOMO1 (if available)
Gene Tree for NOMO1 (if available)

Paralogs for NOMO1 Gene

Paralogs for NOMO1 Gene

(3) SIMAP similar genes for NOMO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NOMO1: view

Variants for NOMO1 Gene

Sequence variations from dbSNP and Humsavar for NOMO1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10085 -- 14,884,476(+) CCTAC(A/G)TTATG reference, synonymous-codon
rs1062412 -- 14,864,657(+) CCTGT(A/C/G/T)GGTCA reference, missense
rs111277484 -- 14,889,244(+) AAAAA(C/T)CCATG intron-variant
rs111361285 -- 14,842,832(+) TATCT(C/G)TATCA intron-variant
rs111424230 -- 14,860,788(+) TCTCT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOMO1 Gene

Variant ID Type Subtype PubMed ID
dgv111n111 CNV duplication 26073780
dgv112n111 CNV duplication 26073780
dgv2738n100 CNV gain 25217958
dgv2740n100 CNV loss 25217958
dgv2741n100 CNV gain+loss 25217958
dgv2742n100 CNV gain 25217958
dgv2744n100 CNV loss 25217958
dgv2745n100 CNV gain 25217958
dgv2746n100 CNV gain+loss 25217958
dgv2747n100 CNV loss 25217958
dgv2749n100 CNV gain 25217958
dgv2750n100 CNV loss 25217958
dgv2751n100 CNV gain 25217958
dgv2752n100 CNV gain+loss 25217958
dgv2753n100 CNV loss 25217958
dgv2754n100 CNV loss 25217958
dgv2755n100 CNV gain 25217958
dgv2756n100 CNV loss 25217958
dgv2757n100 CNV gain+loss 25217958
dgv791e212 CNV loss 25503493
esv22206 CNV gain+loss 19812545
esv2714012 CNV deletion 23290073
esv2714013 CNV deletion 23290073
esv2758632 CNV gain+loss 17122850
esv2760416 CNV gain+loss 21179565
esv2762254 CNV gain+loss 21179565
esv32598 CNV gain 17666407
esv3570331 CNV gain 25503493
esv3584701 CNV loss 24956385
esv994412 CNV gain 20482838
nsv103370 CNV deletion 16902084
nsv1038955 CNV loss 25217958
nsv1075912 CNV duplication 25765185
nsv1110264 CNV duplication 24896259
nsv1141278 CNV duplication 24896259
nsv1152913 CNV duplication 26484159
nsv1160344 CNV deletion 26073780
nsv1160345 CNV duplication 26073780
nsv1160346 CNV duplication 26073780
nsv433435 CNV gain 18776910
nsv442710 CNV gain 18776908
nsv471383 CNV gain 19718026
nsv499081 OTHER inversion 21111241
nsv509597 CNV insertion 20534489
nsv511045 OTHER complex 20534489
nsv7277 OTHER inversion 18451855
nsv9355 CNV gain+loss 18304495
nsv952929 CNV duplication 24416366
nsv974762 CNV duplication 23825009
nsv984263 CNV duplication 23825009

Variation tolerance for NOMO1 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOMO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOMO1 Gene

Disorders for NOMO1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NOMO1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pseudoxanthoma elasticum
  • pseudoxanthoma elasticum, modifier of severity of
superficial urinary bladder cancer
  • superficial urinary bladder carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NOMO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOMO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NOMO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOMO1 Gene

Publications for NOMO1 Gene

  1. Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family. (PMID: 1310294) Templeton N.S. … Stetler-Stevenson W.G. (Genomics 1992) 2 3 4 64
  2. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PMID: 15257293) Haffner C. … Haass C. (EMBO J. 2004) 2 3 64
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  4. Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. (PMID: 11139250) Perdu J. … Germain D.P. (Hum. Mutat. 2001) 4 22 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for NOMO1 Gene

Sources for NOMO1 Gene

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