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Aliases for NOMO1 Gene

Aliases for NOMO1 Gene

  • NODAL Modulator 1 2 3
  • PM5 3 4
  • PM5 Protein, Telomeric Copy 3
  • NODAL Modulator 3 3
  • PM5 Protein 3 3
  • PM5 Protein 4
  • Nomo 3

External Ids for NOMO1 Gene

Previous GeneCards Identifiers for NOMO1 Gene

  • GC16P014836
  • GC16P014927
  • GC16P014730

Summaries for NOMO1 Gene

Entrez Gene Summary for NOMO1 Gene

  • This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). [provided by RefSeq, Jul 2008]

GeneCards Summary for NOMO1 Gene

NOMO1 (NODAL Modulator 1) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is NOMO2.

UniProtKB/Swiss-Prot for NOMO1 Gene

  • May antagonize Nodal signaling.

Gene Wiki entry for NOMO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOMO1 Gene

Genomics for NOMO1 Gene

Regulatory Elements for NOMO1 Gene

Genomic Location for NOMO1 Gene

14,833,681 bp from pter
14,896,160 bp from pter
62,480 bases
Plus strand

Genomic View for NOMO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOMO1 Gene

Proteins for NOMO1 Gene

  • Protein details for NOMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nodal modulator 1
    Protein Accession:
    Secondary Accessions:
    • P78421
    • Q8IW21
    • Q96DG0

    Protein attributes for NOMO1 Gene

    1222 amino acids
    Molecular mass:
    134324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NOMO1 Gene

Proteomics data for NOMO1 Gene at MOPED

Post-translational modifications for NOMO1 Gene

  • Ubiquitination at Lys134, Lys138, Lys159, Lys170, Lys175, Lys193, Lys356, Lys630, Lys770, Lys927, Lys1019, and Lys1079
  • Glycosylation at Asn50, Asn218, Asn369, and Asn618
  • Modification sites at PhosphoSitePlus

Other Protein References for NOMO1 Gene

Antibody Products

No data available for DME Specific Peptides for NOMO1 Gene

Domains for NOMO1 Gene

Protein Domains for NOMO1 Gene

Suggested Antigen Peptide Sequences for NOMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOMO1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOMO1 Gene

Function for NOMO1 Gene

Molecular function for NOMO1 Gene

UniProtKB/Swiss-Prot Function:
May antagonize Nodal signaling.

Gene Ontology (GO) - Molecular Function for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with NOMO1: view

Animal Model Products

miRNA for NOMO1 Gene

miRTarBase miRNAs that target NOMO1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOMO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for NOMO1 Gene

Localization for NOMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOMO1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for NOMO1 Gene COMPARTMENTS Subcellular localization image for NOMO1 gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NOMO1: view

Pathways for NOMO1 Gene

SuperPathways for NOMO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NOMO1: view

No data available for Pathways by source for NOMO1 Gene

Transcripts for NOMO1 Gene

mRNA/cDNA for NOMO1 Gene

Unigene Clusters for NOMO1 Gene

NODAL modulator 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOMO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOMO1 Gene

No ASD Table

Relevant External Links for NOMO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOMO1 Gene

mRNA expression in normal human tissues for NOMO1 Gene

Protein differential expression in normal tissues for NOMO1 Gene

This gene is overexpressed in Pancreas (9.0) and Frontal cortex (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOMO1 Gene

SOURCE GeneReport for Unigene cluster for NOMO1 Gene Hs.743963

mRNA Expression by UniProt/SwissProt for NOMO1 Gene

Tissue specificity: Expressed in colon tumor tissue and in adjacent normal colonic mucosa
genes like me logo Genes that share expressions with NOMO1: view

Expression partners for NOMO1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NOMO1 Gene

Orthologs for NOMO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOMO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOMO1 35
  • 88.48 (n)
  • 94.91 (a)
-- 36
  • 95 (a)
(Canis familiaris)
Mammalia NOMO1 35
  • 90 (n)
  • 95.97 (a)
-- 36
  • 95 (a)
(Mus musculus)
Mammalia Nomo1 35
  • 86.32 (n)
  • 93.45 (a)
Nomo1 16
Nomo1 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Nomo1 35
  • 86.79 (n)
  • 93.85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
(Gallus gallus)
Aves PM5 35
  • 77.17 (n)
  • 87.14 (a)
-- 36
  • 86 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nomo3 35
  • 72.02 (n)
  • 79.98 (a)
(Danio rerio)
Actinopterygii nomo 35
  • 66.67 (n)
  • 70.85 (a)
nomo 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005856 35
  • 45.36 (n)
  • 35.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1371 35
  • 45.94 (n)
  • 34.01 (a)
CG1371 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea nra-4 35
  • 43.03 (n)
  • 27.68 (a)
nra-4 36
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62360 35
  • 45.06 (n)
  • 34.26 (a)
(Oryza sativa)
Liliopsida Os01g0300600 35
  • 45.08 (n)
  • 39.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4870 36
  • 37 (a)
Species with no ortholog for NOMO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOMO1 Gene

Gene Tree for NOMO1 (if available)
Gene Tree for NOMO1 (if available)

Paralogs for NOMO1 Gene

Paralogs for NOMO1 Gene

(3) SIMAP similar genes for NOMO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NOMO1: view

Variants for NOMO1 Gene

Sequence variations from dbSNP and Humsavar for NOMO1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs192251669 -- 14,886,950(+) TTTCT(C/T)CCTAA intron-variant
rs191979186 -- 14,860,828(+) TTAGC(A/T)CACTG intron-variant
rs191945485 -- 14,839,067(+) TTTCT(C/T)CTTTT intron-variant
rs191619332 -- 14,840,607(+) AAACA(A/G)AAACA intron-variant
rs191339747 -- 14,891,454(+) TGATT(C/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOMO1 Gene

Variant ID Type Subtype PubMed ID
dgv811e1 CNV Complex 17122850
nsv905356 CNV Gain 21882294
dgv812e1 CNV Complex 17122850
nsv905357 CNV Gain 21882294
nsv511045 OTHER Complex 20534489
nsv7277 OTHER Inversion 18451855
dgv813e1 CNV Complex 17122850
esv32598 CNV Gain 17666407
nsv509597 CNV Insertion 20534489
nsv471383 CNV Duplication 19718026
dgv2604n71 CNV Gain 21882294
nsv433435 CNV Gain 18776910
esv2714012 CNV Deletion 23290073
esv2714013 CNV Deletion 23290073
nsv103370 CNV Loss 16902084
nsv905361 CNV Gain 21882294
nsv905362 CNV Loss 21882294
esv994412 CNV Gain 20482838
nsv9355 CNV Gain+Loss 18304495
dgv814e1 CNV Complex 17122850
essv12354 CNV CNV 17122850
nsv499081 OTHER Inversion 21111241
esv22206 CNV Gain+Loss 19812545
nsv442710 CNV CNV 18776908

Relevant External Links for NOMO1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOMO1 Gene

Disorders for NOMO1 Gene

No disorders were found for NOMO1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NOMO1 Gene

Publications for NOMO1 Gene

  1. Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family. (PMID: 1310294) Templeton N.S. … Stetler-Stevenson W.G. (Genomics 1992) 2 3 4
  2. Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. (PMID: 11139250) Perdu J. … Germain D.P. (Hum. Mutat. 2001) 4 23
  3. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PMID: 15257293) Haffner C. … Haass C. (EMBO J. 2004) 2 3
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  5. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. (PMID: 15862967) Pope S.N. … Lee I.R. (J. Steroid Biochem. Mol. Biol. 2005) 3

Products for NOMO1 Gene

Sources for NOMO1 Gene

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