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Aliases for NOMO1 Gene

Aliases for NOMO1 Gene

  • NODAL Modulator 1 2 3
  • PM5 3 4
  • PM5 Protein, Telomeric Copy 3
  • NODAL Modulator 3 3
  • PM5 Protein 3 3
  • PM5 Protein 4
  • Nomo 3

External Ids for NOMO1 Gene

Previous GeneCards Identifiers for NOMO1 Gene

  • GC16P014836
  • GC16P014927
  • GC16P014730
  • GC16P014871

Summaries for NOMO1 Gene

Entrez Gene Summary for NOMO1 Gene

  • This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). [provided by RefSeq, Jul 2008]

GeneCards Summary for NOMO1 Gene

NOMO1 (NODAL Modulator 1) is a Protein Coding gene. Diseases associated with NOMO1 include superficial urinary bladder cancer and pseudoxanthoma elasticum. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is NOMO2.

UniProtKB/Swiss-Prot for NOMO1 Gene

  • May antagonize Nodal signaling.

Gene Wiki entry for NOMO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOMO1 Gene

Genomics for NOMO1 Gene

Regulatory Elements for NOMO1 Gene

Genomic Location for NOMO1 Gene

Chromosome:
16
Start:
14,833,681 bp from pter
End:
14,896,160 bp from pter
Size:
62,480 bases
Orientation:
Plus strand

Genomic View for NOMO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOMO1 Gene

Proteins for NOMO1 Gene

  • Protein details for NOMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15155-NOMO1_HUMAN
    Recommended name:
    Nodal modulator 1
    Protein Accession:
    Q15155
    Secondary Accessions:
    • P78421
    • Q8IW21
    • Q96DG0

    Protein attributes for NOMO1 Gene

    Size:
    1222 amino acids
    Molecular mass:
    134324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NOMO1 Gene

Proteomics data for NOMO1 Gene at MOPED

Post-translational modifications for NOMO1 Gene

  • Glycosylation at Asn 50, Asn 218, and Asn 618
  • Modification sites at PhosphoSitePlus

Other Protein References for NOMO1 Gene

No data available for DME Specific Peptides for NOMO1 Gene

Domains & Families for NOMO1 Gene

Protein Domains for NOMO1 Gene

Suggested Antigen Peptide Sequences for NOMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOMO1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOMO1 Gene

Function for NOMO1 Gene

Molecular function for NOMO1 Gene

UniProtKB/Swiss-Prot Function:
May antagonize Nodal signaling.

Gene Ontology (GO) - Molecular Function for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with NOMO1: view

Phenotypes for NOMO1 Gene

GenomeRNAi human phenotypes for NOMO1:
genes like me logo Genes that share phenotypes with NOMO1: view

Animal Model Products

miRNA for NOMO1 Gene

miRTarBase miRNAs that target NOMO1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOMO1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NOMO1 Gene

Localization for NOMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOMO1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOMO1 Gene COMPARTMENTS Subcellular localization image for NOMO1 gene
Compartment Confidence
endoplasmic reticulum 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NOMO1: view

Pathways & Interactions for NOMO1 Gene

SuperPathways for NOMO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NOMO1: view

No data available for Pathways by source and SIGNOR curated interactions for NOMO1 Gene

Drugs & Compounds for NOMO1 Gene

No Compound Related Data Available

Transcripts for NOMO1 Gene

mRNA/cDNA for NOMO1 Gene

Unigene Clusters for NOMO1 Gene

NODAL modulator 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOMO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOMO1 Gene

No ASD Table

Relevant External Links for NOMO1 Gene

GeneLoc Exon Structure for
NOMO1
ECgene alternative splicing isoforms for
NOMO1

Expression for NOMO1 Gene

mRNA expression in normal human tissues for NOMO1 Gene

Protein differential expression in normal tissues from HIPED for NOMO1 Gene

This gene is overexpressed in Pancreas (9.0) and Frontal cortex (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOMO1 Gene



SOURCE GeneReport for Unigene cluster for NOMO1 Gene Hs.743963

mRNA Expression by UniProt/SwissProt for NOMO1 Gene

Q15155-NOMO1_HUMAN
Tissue specificity: Expressed in colon tumor tissue and in adjacent normal colonic mucosa
genes like me logo Genes that share expression patterns with NOMO1: view

Protein tissue co-expression partners for NOMO1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NOMO1 Gene

Orthologs for NOMO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOMO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOMO1 35
  • 88.48 (n)
  • 94.91 (a)
-- 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NOMO1 35
  • 90 (n)
  • 95.97 (a)
-- 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nomo1 35
  • 86.32 (n)
  • 93.45 (a)
Nomo1 16
Nomo1 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nomo1 35
  • 86.79 (n)
  • 93.85 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves PM5 35
  • 77.17 (n)
  • 87.14 (a)
-- 36
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nomo3 35
  • 72.02 (n)
  • 79.98 (a)
zebrafish
(Danio rerio)
Actinopterygii nomo 35
  • 66.67 (n)
  • 70.85 (a)
nomo 36
  • 70 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005856 35
  • 45.36 (n)
  • 35.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1371 35
  • 45.94 (n)
  • 34.01 (a)
CG1371 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nra-4 35
  • 43.03 (n)
  • 27.68 (a)
nra-4 36
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62360 35
  • 45.06 (n)
  • 34.26 (a)
rice
(Oryza sativa)
Liliopsida Os01g0300600 35
  • 45.08 (n)
  • 39.65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4870 36
  • 37 (a)
OneToMany
Species with no ortholog for NOMO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOMO1 Gene

ENSEMBL:
Gene Tree for NOMO1 (if available)
TreeFam:
Gene Tree for NOMO1 (if available)

Paralogs for NOMO1 Gene

Paralogs for NOMO1 Gene

(3) SIMAP similar genes for NOMO1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NOMO1: view

Variants for NOMO1 Gene

Sequence variations from dbSNP and Humsavar for NOMO1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4781631 -- 14,839,024(-) TATCA(A/C/G)AGGTT intron-variant
rs59391735 -- 14,843,715(+) GTGTG(-/TG)CATGT intron-variant
rs115621145 -- 14,874,079(+) CTTCT(C/T)ACCAC intron-variant
rs117243537 -- 14,874,144(+) GCTGG(C/G)CTTCC intron-variant
rs145791074 -- 14,874,098(+) CAGCC(C/T)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOMO1 Gene

Variant ID Type Subtype PubMed ID
dgv811e1 CNV Complex 17122850
nsv905356 CNV Gain 21882294
dgv812e1 CNV Complex 17122850
nsv905357 CNV Gain 21882294
nsv511045 OTHER Complex 20534489
nsv7277 OTHER Inversion 18451855
dgv813e1 CNV Complex 17122850
esv32598 CNV Gain 17666407
nsv509597 CNV Insertion 20534489
nsv471383 CNV Duplication 19718026
dgv2604n71 CNV Gain 21882294
nsv433435 CNV Gain 18776910
esv2714012 CNV Deletion 23290073
esv2714013 CNV Deletion 23290073
nsv103370 CNV Loss 16902084
nsv905361 CNV Gain 21882294
nsv905362 CNV Loss 21882294
esv994412 CNV Gain 20482838
nsv9355 CNV Gain+Loss 18304495
dgv814e1 CNV Complex 17122850
essv12354 CNV CNV 17122850
nsv499081 OTHER Inversion 21111241
esv22206 CNV Gain+Loss 19812545
nsv442710 CNV CNV 18776908

Variation tolerance for NOMO1 Gene

Residual Variation Intolerance Score: 90.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOMO1 Gene

HapMap Linkage Disequilibrium report
NOMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOMO1 Gene

Disorders for NOMO1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NOMO1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
superficial urinary bladder cancer
  • superficial urinary bladder carcinoma
pseudoxanthoma elasticum
  • pseudoxanthoma elasticum, modifier of severity of
- elite association
Search NOMO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOMO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOMO1
genes like me logo Genes that share disorders with NOMO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOMO1 Gene

Publications for NOMO1 Gene

  1. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. (PMID: 15257293) Haffner C. … Haass C. (EMBO J. 2004) 2 67
  2. Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. (PMID: 11139250) Perdu J. … Germain D.P. (Hum. Mutat. 2001) 23 67
  3. Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family. (PMID: 1310294) Templeton N.S. … Stetler-Stevenson W.G. (Genomics 1992) 2 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for NOMO1 Gene

Sources for NOMO1 Gene

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