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Aliases for NOM1 Gene

Aliases for NOM1 Gene

  • Nucleolar Protein With MIF4G Domain 1 2 3
  • C7orf3 3 4 6
  • SGD1 Homolog 3 4
  • Protein Phosphatase 1, Regulatory Subunit 113 3
  • Nucleolar MIF4G Domain-Containing Protein 1 3
  • Chromosome 7 Open Reading Frame 3 2
  • Regulatory Subunit 113 2
  • Protein Phosphatase 1 2
  • PPP1R113 3
  • SGD1 3

External Ids for NOM1 Gene

Previous HGNC Symbols for NOM1 Gene

  • C7orf3

Previous GeneCards Identifiers for NOM1 Gene

  • GC00U921619
  • GC07P156242
  • GC07P156435
  • GC07P156742
  • GC07P150475

Summaries for NOM1 Gene

Entrez Gene Summary for NOM1 Gene

  • Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NOM1 Gene

NOM1 (Nucleolar Protein With MIF4G Domain 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for NOM1 Gene

  • Plays a role in targeting PPP1CA to the nucleolus.

Gene Wiki entry for NOM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOM1 Gene

Genomics for NOM1 Gene

Regulatory Elements for NOM1 Gene

Transcription factor binding sites by QIAGEN in the NOM1 gene promoter:

Genomic Location for NOM1 Gene

156,949,723 bp from pter
156,973,182 bp from pter
23,460 bases
Plus strand

Genomic View for NOM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOM1 Gene

Proteins for NOM1 Gene

  • Protein details for NOM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar MIF4G domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q96I08

    Protein attributes for NOM1 Gene

    860 amino acids
    Molecular mass:
    96257 Da
    Quaternary structure:
    • May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC.

neXtProt entry for NOM1 Gene

Proteomics data for NOM1 Gene at MOPED

Post-translational modifications for NOM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOM1 Gene

Domains for NOM1 Gene

Gene Families for NOM1 Gene

Suggested Antigen Peptide Sequences for NOM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MI domain.
  • Belongs to the CWC22 family.
  • Contains 1 MI domain.
  • Contains 1 MIF4G domain.
  • Belongs to the CWC22 family.
genes like me logo Genes that share domains with NOM1: view

Function for NOM1 Gene

Molecular function for NOM1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in targeting PPP1CA to the nucleolus.

Gene Ontology (GO) - Molecular Function for NOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005488 binding --
GO:0005515 protein binding IPI 17965019
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NOM1: view
genes like me logo Genes that share phenotypes with NOM1: view

Animal Model Products

miRNA for NOM1 Gene

miRTarBase miRNAs that target NOM1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NOM1 Gene

Localization for NOM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOM1 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for NOM1 Gene COMPARTMENTS Subcellular localization image for NOM1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with NOM1: view

Pathways for NOM1 Gene

SuperPathways for NOM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NOM1: view

No data available for Pathways by source for NOM1 Gene

Transcripts for NOM1 Gene

Unigene Clusters for NOM1 Gene

Nucleolar protein with MIF4G domain 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for NOM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOM1 Gene

mRNA expression in normal human tissues for NOM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NOM1 Gene

This gene is overexpressed in Brain (35.9) and Peripheral blood mononuclear cells (10.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOM1 Gene

SOURCE GeneReport for Unigene cluster for NOM1 Gene Hs.15825

mRNA Expression by UniProt/SwissProt for NOM1 Gene

Tissue specificity: Expressed in heart and skeletal muscle.
genes like me logo Genes that share expressions with NOM1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for NOM1 Gene

Orthologs for NOM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOM1 35
  • 75.64 (n)
  • 72.19 (a)
NOM1 36
  • 70 (a)
(Canis familiaris)
Mammalia NOM1 35
  • 75.21 (n)
  • 71.91 (a)
NOM1 36
  • 65 (a)
(Mus musculus)
Mammalia Nom1 35
  • 76.14 (n)
  • 76.52 (a)
Nom1 16
Nom1 36
  • 72 (a)
(Pan troglodytes)
Mammalia NOM1 35
  • 98.41 (n)
  • 97.56 (a)
NOM1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC682058 35
  • 70.25 (n)
  • 67.88 (a)
(Monodelphis domestica)
Mammalia NOM1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia NOM1 36
  • 78 (a)
(Gallus gallus)
Aves NOM1 35
  • 72.42 (n)
  • 72.55 (a)
NOM1 36
  • 55 (a)
(Anolis carolinensis)
Reptilia NOM1 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10492 35
(Danio rerio)
Actinopterygii Dr.6026 35
nom1 35
  • 64.23 (n)
  • 68.06 (a)
nom1 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011285 35
  • 51.09 (n)
  • 44.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9004 35
  • 49.42 (n)
  • 40.5 (a)
CG9004 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y52B11A.10 35
  • 42.1 (n)
  • 31.67 (a)
Y52B11A.10 36
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGD1 36
  • 20 (a)
SGD1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G17930 35
  • 47.11 (n)
  • 35.49 (a)
(Oryza sativa)
Liliopsida Os.18996 35
Os05g0147200 35
  • 47.51 (n)
  • 37.9 (a)
Species with no ortholog for NOM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOM1 Gene

Gene Tree for NOM1 (if available)
Gene Tree for NOM1 (if available)

Paralogs for NOM1 Gene

No data available for Paralogs for NOM1 Gene

Variants for NOM1 Gene

Sequence variations from dbSNP and Humsavar for NOM1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs12919 -, - 156,969,554(-) TAACA(C/T)CCCCA missense, reference
rs887610 -- 156,958,683(-) CCGTA(A/G)CTGTG intron-variant
rs887611 -- 156,958,536(-) CACTA(C/T)CGTGT intron-variant
rs887612 -- 156,958,251(-) GACAA(A/G)ACCAG intron-variant
rs887613 -- 156,958,149(-) TCCAC(C/T)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOM1 Gene

Variant ID Type Subtype PubMed ID
nsv889568 CNV Loss 21882294
nsv889569 CNV Loss 21882294
nsv465249 CNV Loss 19166990
esv2735655 CNV Deletion 23290073
nsv824415 CNV Gain 20364138

Relevant External Links for NOM1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOM1 Gene

Disorders for NOM1 Gene

Relevant External Links for NOM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for NOM1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NOM1 Gene

Publications for NOM1 Gene

  1. A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36. (PMID: 10329000) Heus H.C. … Heutink P. (Genomics 1999) 2 3 4
  2. Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia. (PMID: 15715967) Simmons H.M. … Conklin K.F. (Gene 2005) 3 4
  3. NOM1 targets protein phosphatase I to the nucleolus. (PMID: 17965019) Gunawardena S.R. … Conklin K.F. (J. Biol. Chem. 2008) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex. (PMID: 21576267) Alexandrov A. … Steitz J.A. (Genes Dev. 2011) 3

Products for NOM1 Gene

Sources for NOM1 Gene

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