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Aliases for NOM1 Gene

Aliases for NOM1 Gene

  • Nucleolar Protein With MIF4G Domain 1 2 3 5
  • SGD1 Homolog 3 4
  • C7orf3 3 4
  • Protein Phosphatase 1, Regulatory Subunit 113 3
  • Chromosome 7 Open Reading Frame 3 2
  • Regulatory Subunit 113 2
  • Protein Phosphatase 1 2
  • PPP1R113 3
  • SGD1 3

External Ids for NOM1 Gene

Previous HGNC Symbols for NOM1 Gene

  • C7orf3

Previous GeneCards Identifiers for NOM1 Gene

  • GC00U921619
  • GC07P156242
  • GC07P156435
  • GC07P156742
  • GC07P150475

Summaries for NOM1 Gene

Entrez Gene Summary for NOM1 Gene

  • Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NOM1 Gene

NOM1 (Nucleolar Protein With MIF4G Domain 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for NOM1 Gene

  • Plays a role in targeting PPP1CA to the nucleolus.

Gene Wiki entry for NOM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOM1 Gene

Genomics for NOM1 Gene

Regulatory Elements for NOM1 Gene

Enhancers for NOM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOM1 on UCSC Golden Path with GeneCards custom track

Promoters for NOM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOM1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NOM1 gene promoter:

Genomic Location for NOM1 Gene

Chromosome:
7
Start:
156,949,723 bp from pter
End:
156,973,182 bp from pter
Size:
23,460 bases
Orientation:
Plus strand

Genomic View for NOM1 Gene

Genes around NOM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOM1 Gene

Proteins for NOM1 Gene

  • Protein details for NOM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5C9Z4-NOM1_HUMAN
    Recommended name:
    Nucleolar MIF4G domain-containing protein 1
    Protein Accession:
    Q5C9Z4
    Secondary Accessions:
    • Q96I08

    Protein attributes for NOM1 Gene

    Size:
    860 amino acids
    Molecular mass:
    96257 Da
    Quaternary structure:
    • May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC.

neXtProt entry for NOM1 Gene

Proteomics data for NOM1 Gene at MOPED

Post-translational modifications for NOM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOM1 Gene

Domains & Families for NOM1 Gene

Gene Families for NOM1 Gene

Suggested Antigen Peptide Sequences for NOM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5C9Z4

UniProtKB/Swiss-Prot:

NOM1_HUMAN :
  • Contains 1 MI domain.
  • Belongs to the CWC22 family.
Domain:
  • Contains 1 MI domain.
  • Contains 1 MIF4G domain.
Family:
  • Belongs to the CWC22 family.
genes like me logo Genes that share domains with NOM1: view

Function for NOM1 Gene

Molecular function for NOM1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in targeting PPP1CA to the nucleolus.

Gene Ontology (GO) - Molecular Function for NOM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NOM1: view
genes like me logo Genes that share phenotypes with NOM1: view

Animal Model Products

miRNA for NOM1 Gene

miRTarBase miRNAs that target NOM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOM1 Gene

Localization for NOM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOM1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOM1 Gene COMPARTMENTS Subcellular localization image for NOM1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for NOM1 Gene

Pathways & Interactions for NOM1 Gene

SuperPathways for NOM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOM1 Gene

Drugs & Compounds for NOM1 Gene

No Compound Related Data Available

Transcripts for NOM1 Gene

Unigene Clusters for NOM1 Gene

Nucleolar protein with MIF4G domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOM1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for NOM1 Gene

GeneLoc Exon Structure for
NOM1
ECgene alternative splicing isoforms for
NOM1

Expression for NOM1 Gene

mRNA expression in normal human tissues for NOM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOM1 Gene

This gene is overexpressed in Brain (35.9) and Peripheral blood mononuclear cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOM1 Gene



SOURCE GeneReport for Unigene cluster for NOM1 Gene Hs.15825

mRNA Expression by UniProt/SwissProt for NOM1 Gene

Q5C9Z4-NOM1_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with NOM1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for NOM1 Gene

Orthologs for NOM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOM1 35
  • 75.64 (n)
  • 72.19 (a)
NOM1 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOM1 35
  • 75.21 (n)
  • 71.91 (a)
NOM1 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nom1 35
  • 76.14 (n)
  • 76.52 (a)
Nom1 16
Nom1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOM1 35
  • 98.41 (n)
  • 97.56 (a)
NOM1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOM1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOM1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC682058 35
  • 70.25 (n)
  • 67.88 (a)
chicken
(Gallus gallus)
Aves NOM1 35
  • 72.42 (n)
  • 72.55 (a)
NOM1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOM1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10492 35
zebrafish
(Danio rerio)
Actinopterygii Dr.6026 35
nom1 35
  • 64.23 (n)
  • 68.06 (a)
nom1 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011285 35
  • 51.09 (n)
  • 44.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9004 35
  • 49.42 (n)
  • 40.5 (a)
CG9004 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y52B11A.10 35
  • 42.1 (n)
  • 31.67 (a)
Y52B11A.10 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGD1 38
SGD1 36
  • 20 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G17930 35
  • 47.11 (n)
  • 35.49 (a)
rice
(Oryza sativa)
Liliopsida Os05g0147200 35
  • 47.51 (n)
  • 37.9 (a)
Os.18996 35
Species with no ortholog for NOM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOM1 Gene

ENSEMBL:
Gene Tree for NOM1 (if available)
TreeFam:
Gene Tree for NOM1 (if available)

Paralogs for NOM1 Gene

No data available for Paralogs for NOM1 Gene

Variants for NOM1 Gene

Sequence variations from dbSNP and Humsavar for NOM1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6952214 - 156,950,102(+) CGGTC(A/C)CCGGC nc-transcript-variant, reference, missense
rs2302445 - 156,969,124(-) AAAAA(C/T)GGACT nc-transcript-variant, reference, missense
rs2302443 - 156,969,530(-) AGATA(C/G)TCTGG nc-transcript-variant, reference, missense
rs12919 -, - 156,969,554(-) TAACA(C/T)CCCCA nc-transcript-variant, reference, missense
rs6969990 - 156,949,807(+) TGAAG(C/G)GCAGA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NOM1 Gene

Variant ID Type Subtype PubMed ID
nsv889568 CNV Loss 21882294
nsv889569 CNV Loss 21882294
nsv465249 CNV Loss 19166990
esv2735655 CNV Deletion 23290073
nsv824415 CNV Gain 20364138

Variation tolerance for NOM1 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.23; 99.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOM1 Gene

HapMap Linkage Disequilibrium report
NOM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOM1 Gene

Disorders for NOM1 Gene

Relevant External Links for NOM1

Genetic Association Database (GAD)
NOM1
Human Genome Epidemiology (HuGE) Navigator
NOM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOM1

No disorders were found for NOM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOM1 Gene

Publications for NOM1 Gene

  1. A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36. (PMID: 10329000) Heus H.C. … Heutink P. (Genomics 1999) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for NOM1 Gene

Sources for NOM1 Gene

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