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Aliases for NOLC1 Gene

Aliases for NOLC1 Gene

  • Nucleolar And Coiled-Body Phosphoprotein 1 2 3 5
  • Hepatitis C Virus NS5A-Transactivated Protein 13 3 4
  • HCV NS5A-Transactivated Protein 13 3 4
  • 140 KDa Nucleolar Phosphoprotein 3 4
  • Nucleolar Phosphoprotein P130 3 4
  • Nucleolar 130 KDa Protein 3 4
  • NS5ATP13 3 4
  • NOPP140 3 4
  • Nucleolar And Coiled-Body Phosphprotein 1 3
  • HCV NS5A Trans-Regulated Protein 13 3
  • Nucleolar Protein P130 3
  • KIAA0035 4
  • NOPP130 3
  • P130 3

External Ids for NOLC1 Gene

Previous GeneCards Identifiers for NOLC1 Gene

  • GC10P102805
  • GC10P103145
  • GC10P104043
  • GC10P103576
  • GC10P103902
  • GC10P097544

Summaries for NOLC1 Gene

GeneCards Summary for NOLC1 Gene

NOLC1 (Nucleolar And Coiled-Body Phosphoprotein 1) is a Protein Coding gene. Diseases associated with NOLC1 include Warburg Micro Syndrome 1 and Hepatitis C Virus. GO annotations related to this gene include poly(A) RNA binding and GTP binding.

UniProtKB/Swiss-Prot for NOLC1 Gene

  • Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I.

Gene Wiki entry for NOLC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOLC1 Gene

Genomics for NOLC1 Gene

Regulatory Elements for NOLC1 Gene

Enhancers for NOLC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NOLC1 on UCSC Golden Path with GeneCards custom track

Promoters for NOLC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOLC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOLC1 Gene

Chromosome:
10
Start:
102,152,176 bp from pter
End:
102,163,871 bp from pter
Size:
11,696 bases
Orientation:
Plus strand

Genomic View for NOLC1 Gene

Genes around NOLC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOLC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOLC1 Gene

Proteins for NOLC1 Gene

  • Protein details for NOLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14978-NOLC1_HUMAN
    Recommended name:
    Nucleolar and coiled-body phosphoprotein 1
    Protein Accession:
    Q14978
    Secondary Accessions:
    • Q15030
    • Q5VV70
    • Q9BUV3

    Protein attributes for NOLC1 Gene

    Size:
    699 amino acids
    Molecular mass:
    73603 Da
    Quaternary structure:
    • Interacts with RNA polymerase I 194 kDa subunit (RPA194) and with casein kinase-II.

    Alternative splice isoforms for NOLC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOLC1 Gene

Post-translational modifications for NOLC1 Gene

  • Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. There is evidence suggesting that CDK1 kinase phosphorylates p130 at the M-phase.
  • Ubiquitination at Lys 59
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NOLC1 Gene

Domains & Families for NOLC1 Gene

Protein Domains for NOLC1 Gene

Suggested Antigen Peptide Sequences for NOLC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14978

UniProtKB/Swiss-Prot:

NOLC1_HUMAN :
  • Contains 1 LisH domain.
Domain:
  • Contains 1 LisH domain.
genes like me logo Genes that share domains with NOLC1: view

No data available for Gene Families for NOLC1 Gene

Function for NOLC1 Gene

Molecular function for NOLC1 Gene

UniProtKB/Swiss-Prot Function:
Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I.

Gene Ontology (GO) - Molecular Function for NOLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17620599
GO:0005524 ATP binding IEA --
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOLC1: view
genes like me logo Genes that share phenotypes with NOLC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOLC1 Gene

Localization for NOLC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOLC1 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOLC1 Gene COMPARTMENTS Subcellular localization image for NOLC1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NOLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA,IBA --
GO:0005730 nucleolus IEA,IDA --
GO:0005737 cytoplasm IEA --
GO:0015030 Cajal body IEA --
genes like me logo Genes that share ontologies with NOLC1: view

Pathways & Interactions for NOLC1 Gene

SuperPathways for NOLC1 Gene

No Data Available

SIGNOR curated interactions for NOLC1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NOLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS 7657714
GO:0007000 nucleolus organization IEA --
GO:0007049 cell cycle TAS 7657714
GO:0007067 mitotic nuclear division TAS 7657714
genes like me logo Genes that share ontologies with NOLC1: view

No data available for Pathways by source for NOLC1 Gene

Drugs & Compounds for NOLC1 Gene

(4) Drugs for NOLC1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with NOLC1: view

Transcripts for NOLC1 Gene

Unigene Clusters for NOLC1 Gene

Nucleolar and coiled-body phosphoprotein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOLC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2:
SP3: - - - -
SP4: -
SP5:
SP6: - - -
SP7: -
SP8: - - - - - - -
SP9:

Relevant External Links for NOLC1 Gene

GeneLoc Exon Structure for
NOLC1
ECgene alternative splicing isoforms for
NOLC1

Expression for NOLC1 Gene

mRNA expression in normal human tissues for NOLC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOLC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.3), Adrenal (10.4), Nasal epithelium (9.8), and Lung (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOLC1 Gene



Protein tissue co-expression partners for NOLC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOLC1 Gene:

NOLC1

SOURCE GeneReport for Unigene cluster for NOLC1 Gene:

Hs.523238
genes like me logo Genes that share expression patterns with NOLC1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOLC1 Gene

Orthologs for NOLC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOLC1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NOLC1 35
  • 81 (a)
OneToOne
NOLC1 34
  • 82.69 (n)
  • 79.91 (a)
mouse
(Mus musculus)
Mammalia Nolc1 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOLC1 35
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOLC1 35
  • 46 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOLC1 35
  • 81 (a)
OneToOne
NOLC1 34
  • 79 (n)
  • 76.49 (a)
rat
(Rattus norvegicus)
Mammalia Nolc1 34
  • 77.17 (n)
  • 72.25 (a)
chimpanzee
(Pan troglodytes)
Mammalia NOLC1 34
  • 99 (n)
  • 98.43 (a)
NOLC1 35
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOLC1 35
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOLC1 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC395027 34
African clawed frog
(Xenopus laevis)
Amphibia xNopp180 34
zebrafish
(Danio rerio)
Actinopterygii nolc1 35
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dao-5 35
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP40 35
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11097 35
  • 29 (a)
OneToOne
Species where no ortholog for NOLC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOLC1 Gene

ENSEMBL:
Gene Tree for NOLC1 (if available)
TreeFam:
Gene Tree for NOLC1 (if available)

Paralogs for NOLC1 Gene

Pseudogenes.org Pseudogenes for NOLC1 Gene

genes like me logo Genes that share paralogs with NOLC1: view

No data available for Paralogs for NOLC1 Gene

Variants for NOLC1 Gene

Sequence variations from dbSNP and Humsavar for NOLC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11191224 - 102,160,587(+) GGGCG(G/T)TGGCC reference, missense
rs1049455 - 102,160,718(+) CTCTA(C/T)CTCTG reference, missense
rs35183508 -- 102,159,094(+) AAAAA(-/A)TGGTG intron-variant
rs1049466 -- 102,162,306(+) TGATC(A/C/G/T)GAGAC utr-variant-3-prime
rs1057950 -- 102,157,513(+) TCCAG(A/T)GATGA reference, missense

Variation tolerance for NOLC1 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOLC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOLC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NOLC1 Gene

Disorders for NOLC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NOLC1 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
warburg micro syndrome 1
  • micro syndrome
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards
Search NOLC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOLC1

Genetic Association Database (GAD)
NOLC1
Human Genome Epidemiology (HuGE) Navigator
NOLC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOLC1
genes like me logo Genes that share disorders with NOLC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOLC1 Gene

Publications for NOLC1 Gene

  1. Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization. (PMID: 10567578) Chen H.-K. … Yeh N.-H. (Mol. Cell. Biol. 1999) 2 3 4 22 65
  2. Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis. (PMID: 7657714) Pai C.-Y. … Yeh N.-H. (J. Cell Sci. 1995) 2 3 4 22 65
  3. The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+. (PMID: 9016786) Chen H.-K. … Yeh N.-H. (Biochem. Biophys. Res. Commun. 1997) 3 4 22 65
  4. Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130. (PMID: 8630004) Pai C.-Y. … Yeh N.-H. (Biochem. Biophys. Res. Commun. 1996) 3 4 22 65
  5. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 3 4 65

Products for NOLC1 Gene

Sources for NOLC1 Gene

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