Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOLC1 Gene

protein-coding   GIFtS: 56
GCID: GC10P103902

Nucleolar And Coiled-Body Phosphoprotein 1

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nucleolar And Coiled-Body Phosphoprotein 11 2     NOPP1402
Hepatitis C Virus NS5A-Transactivated Protein 132 3     P1302
Nucleolar 130 KDa Protein2 3     HCV NS5A Trans-Regulated Protein 132
Nucleolar Phosphoprotein P1302 3     Nucleolar And Coiled-Body Phosphprotein 12
140 KDa Nucleolar Phosphoprotein2 3     Nucleolar Protein P1302
NS5ATP132 3     KIAA00353
HCV NS5A-Transactivated Protein 132 3     Nopp1403
NOPP1302     

External Ids:    HGNC: 156081   Entrez Gene: 92212   Ensembl: ENSG000001661977   OMIM: 6023945   UniProtKB: Q149783   

Export aliases for NOLC1 gene to outside databases

Previous GC identifers: GC10P102805 GC10P103145 GC10P104043 GC10P103576 GC10P097544


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NOLC1 Gene: 
NOLC1 (nucleolar and coiled-body phosphoprotein 1) is a protein-coding gene. Diseases associated with NOLC1 include treacher collins syndrome, and hepatitis c. GO annotations related to this gene include GTP binding and ATP binding.

UniProtKB/Swiss-Prot: NOLC1_HUMAN, Q14978
Function: Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the
fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities.
May play an important role in transcription catalyzed by RNA polymerase I

Gene Wiki entry for NOLC1 (Nucleolar phosphoprotein p130) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOLC1 gene promoter:
         Pax-5   IRF-1   E47   AREB6   Max   E2F-1   E2F   Hand1   c-Myb   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NOLC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NOLC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOLC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.32

NOLC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOLC1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P103902:  view genomic region     (about GC identifiers)

Start:
103,911,933 bp from pter      End:
103,923,627 bp from pter
Size:
11,695 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOLC1_HUMAN, Q14978 (See protein sequence)
Recommended Name: Nucleolar and coiled-body phosphoprotein 1  
Size: 699 amino acids; 73603 Da
Subunit: Interacts with RNA polymerase I 194 kDa subunit (RPA194) and with casein kinase-II
Subcellular location: Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At
telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to
nucleoli at the early G1-phase
Secondary accessions: Q15030 Q5VV70 Q9BUV3
Alternative splicing: 3 isoforms:  Q14978-1   Q14978-2   Q14978-3   

Explore the universe of human proteins at neXtProt for NOLC1: NX_Q14978

Explore proteomics data for NOLC1 at MOPED 

Post-translational modifications:

  • UniProtKB: Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. There is evidence
    suggesting that CDK1 kinase phosphorylates p130 at the M-phase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14978

  • NOLC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOLC1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001271317.1  NP_001271318.1  NP_004732.2  

    ENSEMBL proteins: 
     ENSP00000474710   ENSP00000473910   ENSP00000475080   ENSP00000474924   ENSP00000473927  
     ENSP00000474140   ENSP00000359024   ENSP00000385410   ENSP00000473835  

    Human Recombinant Protein Products for NOLC1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NOLC1
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for NOLC1 
    OriGene Custom Protein Services for NOLC1
    GenScript Custom Purified and Recombinant Proteins Services for NOLC1
    Novus Biologicals NOLC1 Protein
    Novus Biologicals NOLC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOLC1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0015030Cajal body ----

    NOLC1 for ontologies           About GeneDecksing



    NOLC1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NOLC1
    GenScript Custom Superior Antibodies Services for NOLC1
    Novus Biologicals NOLC1 Antibodies
    Abcam antibodies for NOLC1
    Cloud-Clone Corp. Antibodies for NOLC1 
    Search ThermoFisher Antibodies for NOLC1
    LSBio Antibodies in human, mouse, rat for NOLC1 

    Assay Products for NOLC1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NOLC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NOLC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NOLC1 
    Cloud-Clone Corp. CLIAs for NOLC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006594 LisH_dimerisation
     IPR007718 SRP40_C

    Graphical View of Domain Structure for InterPro Entry Q14978

    ProtoNet protein and cluster: Q14978

    2 Blocks protein domains:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB007718 SRP40


    UniProtKB/Swiss-Prot: NOLC1_HUMAN, Q14978
    Similarity: Contains 1 LisH domain


    NOLC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOLC1_HUMAN, Q14978
    Function: Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the
    fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities.
    May play an important role in transcription catalyzed by RNA polymerase I

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17620599
    GO:0005524ATP binding IEA--
    GO:0005525GTP binding IEA--
         
    NOLC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NOLC1:
     Decreased viability of wild-ty  Increased cell death in breast 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NOLC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOLC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOLC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOLC1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOLC1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate NOLC1 (see all 15):
    hsa-miR-3163 hsa-miR-3166 hsa-miR-513a-3p hsa-miR-575 hsa-miR-3065-5p hsa-miR-181a-2* hsa-miR-3647-3p hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidNOLC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NOLC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOLC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOLC1
    Sirion Biotech Customized adenovirus for overexpression of NOLC1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NOLC1 (see all 12)
    OriGene ORF clones in mouse, rat for NOLC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOLC1 (NM_004741)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOLC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOLC1
    Sirion Biotech Customized lentivirus for stable overexpression of NOLC1 
                         Customized lentivirus expression plasmids for stable overexpression of NOLC1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NOLC1
    Search LifeMap BioReagents cell lines for NOLC1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOLC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOLC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/620 Interacting proteins for NOLC1 (Q149781, 2, 3 ENSP000003590244) via UniProtKB, MINT, STRING, and/or I2D (see all 620)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50812 I2D: score=4 STRING: ENSP00000306330
    ARRB2P321211, 3, ENSP000002692604EBI-396155,EBI-714559 I2D: score=2 STRING: ENSP00000269260
    CSNK2BP678703, ENSP000003650254I2D: score=3 STRING: ENSP00000365025
    ENSG00000224774P678703, ENSP000004156154I2D: score=3 STRING: ENSP00000415615
    ENSG00000206406P678703I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing TAS7657714
    GO:0007000nucleolus organization ----
    GO:0007049cell cycle TAS7657714
    GO:0007067mitosis TAS7657714

    NOLC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NOLC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOLC1

    1 HMDB Compound for NOLC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for NOLC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actinomycin d 36.3 1 7657714 (1)
    tyrosine 9.5 6 2110361 (2), 7929090 (1), 8843705 (1)
    serine 6.71 1 8972203 (1)

    Search CenterWatch for drugs/clinical trials and news about NOLC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOLC1 gene (3 alternative transcripts): 
    NM_001284388.1  NM_001284389.1  NM_004741.4  

    Unigene Cluster for NOLC1:

    Nucleolar and coiled-body phosphoprotein 1
    Hs.523238  [show with all ESTs]
    Unigene Representative Sequence: NM_004741
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000605788 ENST00000464969 ENST00000488254 ENST00000603946 ENST00000461421
    ENST00000476468 ENST00000370007 ENST00000477977 ENST00000405356(uc001kuo.2 uc001kup.2 uc001kuq.2 uc009xxb.1 uc001kur.2)
    ENST00000603742

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOLC1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate NOLC1 (see all 15):
    hsa-miR-3163 hsa-miR-3166 hsa-miR-513a-3p hsa-miR-575 hsa-miR-3065-5p hsa-miR-181a-2* hsa-miR-3647-3p hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidNOLC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NOLC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOLC1
    Clone
    Products:
         
    OriGene clones in human, mouse for NOLC1 (see all 12)
    OriGene ORF clones in mouse, rat for NOLC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOLC1 (NM_004741)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOLC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOLC1
    Sirion Biotech Customized lentivirus for stable overexpression of NOLC1 
                         Customized lentivirus expression plasmids for stable overexpression of NOLC1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NOLC1
    OriGene qSTAR qPCR primer pairs in human, mouse for NOLC1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOLC1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOLC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOLC1

    Additional mRNA sequence: 

    AK056755.1 AK225101.1 AK314363.1 AY820769.1 BC001883.1 BC006769.2 D21262.1 L37710.1 
    Z34289.1 

    19 DOTS entries:

    DT.95375575  DT.95375581  DT.100887542  DT.454013  DT.100887523  DT.92453349  DT.95264724  DT.100031741 
    DT.100758167  DT.100887529  DT.101958343  DT.102833293  DT.121256181  DT.100887513  DT.92453356  DT.100887538 
    DT.86855693  DT.95149496  DT.99991864 

    24/660 AceView cDNA sequences (see all 660):

    BI093466 AU142269 BE502347 AW139816 BM015893 BM848712 BM799006 AA315951 
    BE467847 BM451599 BF223584 BM769050 AA317943 CB136250 BC006769 AA569154 
    BM819999 BE671883 F08714 BM473772 AW302583 BE463909 AI341272 BX422101 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NOLC1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                          -                                                                     
    SP2:                                                                                                                                                
    SP3:                          -     -     -                                   -                                                                     
    SP4:                                                                          -                                                                     
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for NOLC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOLC1 expression in normal human tissues (normalized intensities)      NOLC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAAAAGTTC
    NOLC1 Expression
    About this image


    NOLC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium (Uncategorized)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             epididymis ; glandular cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             liver ; bile duct cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   

    See NOLC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOLC1

    SOURCE GeneReport for Unigene cluster: Hs.523238
        SABiosciences Custom PCR Arrays for NOLC1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NOLC1
    OriGene qSTAR qPCR primer pairs in human, mouse for NOLC1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOLC1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOLC1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOLC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOLC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NOLC1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nolc11 , 5 nucleolar and coiled-body phosphoprotein 11, 5 80.81(n)1
    77.32(a)1
      19 (38.75 cM)5
    707691  NM_001039353.11  NP_001034442.11 
     460758635 
    chicken
    (Gallus gallus)
    Aves NOLC11 nucleolar and coiled-body phosphoprotein 1 60.91(n)
    57.19(a)
      423755  XM_421630.3  XP_421630.3 
    lizard
    (Anolis carolinensis)
    Reptilia NOLC16
    nucleolar and coiled-body phosphoprotein 1
    39(a)
    1 ↔ 1
    GL343196.1(690910-714043)
    African clawed frog
    (Xenopus laevis)
    Amphibia xNopp1802 nucleolar phosphoprotein 73.57(n)    X88927.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nolc11 nucleolar and coiled-body phosphoprotein 1 48.95(n)
    47.18(a)
      561131  XM_684535.5  XP_689627.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta mxc6
    CG121056
    (see all 5)
    --
    5(a)
    4(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    X(9130834-9137237)
    3L(1610696-1615801)
    worm
    (Caenorhabditis elegans)
    Secernentea dao-51 Protein DAO-5 46.53(n)
    39.96(a)
      266845  NM_001025833.4  NP_001021004.1 


    ENSEMBL Gene Tree for NOLC1 (if available)
    TreeFam Gene Tree for NOLC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOLC1 gene

    NOLC1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NOLC1
    PGOHUM00000245641 PGOHUM00000249807 PGOHUM00000241184


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/323 SNPs in NOLC1 are shown (see all 323)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400751211,2
    --103910688(+) TCTCCC/TGCCTC 1 -- us2k10--------
    rs1872824861,2
    --103911043(+) TGGCTA/CATTTT 1 -- us2k10--------
    rs1152806881,2
    F--103911353(+) TGATAC/TTGGAG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1917460011,2
    --103911636(+) AGTCTA/GGAGGC 1 -- us2k10--------
    rs171143931,2
    C,F--103911695(+) TGAAGG/AGCGAG 1 -- us2k13Minor allele frequency- A:0.10MN EA 476
    rs70749121,2
    C,F,H--103911763(+) TGTTCG/TAGCCC 1 -- us2k110Minor allele frequency- T:0.02NS EA NA WA 1202
    rs564124421,2
    C,F--103911970(+) GCGATA/TCGCGT 1 -- ut511Minor allele frequency- T:0.02NA 120
    rs171143971,2
    C,F,H--103912003(+) TTTCCC/GGTCTA 1 -- ut5111Minor allele frequency- G:0.09NA NS EA WA CSA 802
    rs171144011,2
    C,F,H--103912015(+) CCTACC/TTCTGA 1 -- ut51 tfbs311Minor allele frequency- T:0.15NA NS EA WA CSA 686
    rs1174435951,2
    F--103912079(+) GGCGCA/GATGAC 1 -- ut511Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for NOLC1 (103911933 - 103923627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NOLC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv895968CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NOLC1
    DNA2.0 Custom Variant and Variant Library Synthesis for NOLC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602394    OMIM disorders: --

    10 diseases for NOLC1:    About MalaCards
    treacher collins syndrome    hepatitis c    hepatitis    lissencephaly
    spinal muscular atrophy    muscular atrophy    nasopharyngitis    hypoxia
    alzheimer's disease    gastric cancer


    NOLC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for NOLC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    response acute phase 54.8 1 12167624 (1)

    Genetic Association Database (GAD): NOLC1
    Human Genome Epidemiology (HuGE) Navigator: NOLC1 (1 document)

    Export disorders for NOLC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOLC1 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with NOLC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis. (PubMed id 7657714)1, 2, 3, 9 Pai C.-Y.... Yeh N.-H. (1995)
    2. Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization. (PubMed id 10567578)1, 2, 3, 9 Chen H.-K.... Yeh N.-H. (1999)
    3. The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+. (PubMed id 9016786)1, 2, 9 Chen H.-K. and Yeh N.-H. (1997)
    4. Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130. (PubMed id 8630004)1, 2, 9 Pai C.-Y. and Yeh N.-H. (1996)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    9. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    10. Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor. (PubMed id 8972203)1, 9 Miau L.H....Lee S.C. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9221 HGNC: 15608 AceView: NOLC1 Ensembl:ENSG00000166197 euGenes: HUgn9221
    ECgene: NOLC1 H-InvDB: NOLC1

    (According to HUGE)
    About This Section
    HUGE: KIAA0035

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOLC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOLC1 gene:
    Search GeneIP for patents involving NOLC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NOLC1  
     OriGene qPCR primer pairs and template standards for NOLC1   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for NOLC1   OriGene clones in human, mouse for NOLC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NOLC1   OriGene Purified Protein for NOLC1  
     OriGene ORF clones in mouse, rat for NOLC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NOLC1   OriGene Custom Protein Services for NOLC1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOLC1
     QIAGEN SeqTarget long-range PCR primers for resequencing NOLC1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOLC1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOLC1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOLC1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOLC1
     GenScript Custom Purified and Recombinant Proteins Services for NOLC1 GenScript cDNA clones with any tag delivered in your preferred vector for NOLC1
     GenScript Custom Assay Services for NOLC1 GenScript Custom Superior Antibodies Services for NOLC1
     GenScript Custom overexpressing Cell Line Services for NOLC1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NOLC1 promoter
     Search Chromatin IP Primers for NOLC1
     RT2 qPCR Primer Assay in human, mouse, rat NOLC1
     GNC Network for NOLC1
     SABiosciences Custom PCR Arrays for NOLC1
     Search Tocris compounds for NOLC1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NOLC1 antibodies
     NOLC1 proteins
     NOLC1 lysates
     Antibodies for NOLC1
     See all of Abcam's Antibodies, Kits and Proteins for NOLC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NOLC1
     Antibodies for NOLC1
     ELISAs for NOLC1
     CLIAs for NOLC1
     Search LifeMap BioReagents cell lines for NOLC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOLC1
     SwitchGear 3'UTR luciferase reporter plasmids for NOLC1
     SwitchGear Promoter luciferase reporter plasmids for NOLC1
     Search ThermoFisher Antibodies for NOLC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOLC1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NOLC1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOLC1
    Customized:
     lentivirus for stable overexpression of NOLC1
     lentivirus expression plasmids for stable overexpression of NOLC1
     adenovirus for overexpression of NOLC1
     LSBio Antibodies in human, mouse, rat for NOLC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NOLC1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4