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Aliases for NOLC1 Gene

Aliases for NOLC1 Gene

  • Nucleolar And Coiled-Body Phosphoprotein 1 2 3
  • NOPP140 3 4 6
  • Hepatitis C Virus NS5A-Transactivated Protein 13 3 4
  • HCV NS5A-Transactivated Protein 13 3 4
  • 140 KDa Nucleolar Phosphoprotein 3 4
  • Nucleolar Phosphoprotein P130 3 4
  • Nucleolar 130 KDa Protein 3 4
  • NS5ATP13 3 4
  • P130 3 6
  • Nucleolar And Coiled-Body Phosphprotein 1 3
  • HCV NS5A Trans-Regulated Protein 13 3
  • Nucleolar Protein P130 3
  • KIAA0035 4
  • NOPP130 3

External Ids for NOLC1 Gene

Summaries for NOLC1 Gene

GeneCards Summary for NOLC1 Gene

NOLC1 (Nucleolar And Coiled-Body Phosphoprotein 1) is a Protein Coding gene. Diseases associated with NOLC1 include hepatitis c virus and hepatitis c. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for NOLC1 Gene

  • Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I

Gene Wiki entry for NOLC1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOLC1 Gene

Genomics for NOLC1 Gene

Genomic Location for NOLC1 Gene

Start:
102,152,176 bp from pter
End:
102,163,871 bp from pter
Size:
11,696 bases
Orientation:
Plus strand

Genomic View for NOLC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOLC1 Gene

Regulatory Elements for NOLC1 Gene

Proteins for NOLC1 Gene

  • Protein details for NOLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14978-NOLC1_HUMAN
    Recommended name:
    Nucleolar and coiled-body phosphoprotein 1
    Protein Accession:
    Q14978
    Secondary Accessions:
    • Q15030
    • Q5VV70
    • Q9BUV3

    Protein attributes for NOLC1 Gene

    Size:
    699 amino acids
    Molecular mass:
    73603 Da
    Quaternary structure:
    • Interacts with RNA polymerase I 194 kDa subunit (RPA194) and with casein kinase-II

    Alternative splice isoforms for NOLC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOLC1 Gene

Proteomics data for NOLC1 Gene at MOPED

Post-translational modifications for NOLC1 Gene

  • Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. There is evidence suggesting that CDK1 kinase phosphorylates p130 at the M-phase
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys33 and Lys59

No data available for DME Specific Peptides for NOLC1 Gene

Domains for NOLC1 Gene

Protein Domains for NOLC1 Gene

UniProtKB/Swiss-Prot:

NOLC1_HUMAN
Domain:
  • Contains 1 LisH domain.:
    • Q14978
genes like me logo Genes that share domains with NOLC1: view

No data available for Gene Families for NOLC1 Gene

Function for NOLC1 Gene

Molecular function for NOLC1 Gene

UniProtKB/Swiss-Prot Function: Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I

Gene Ontology (GO) - Molecular Function for NOLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17620599
GO:0005524 ATP binding IEA --
GO:0005525 GTP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOLC1: view
genes like me logo Genes that share phenotypes with NOLC1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NOLC1 Gene

Localization for NOLC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOLC1 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOLC1 Gene COMPARTMENTS Subcellular localization image for NOLC1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for NOLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0015030 Cajal body IEA --
genes like me logo Genes that share ontologies with NOLC1: view

Pathways for NOLC1 Gene

SuperPathways for NOLC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS 7657714
GO:0007000 nucleolus organization IEA --
GO:0007049 cell cycle TAS 7657714
GO:0007067 mitotic nuclear division TAS 7657714
genes like me logo Genes that share ontologies with NOLC1: view

No data available for Pathways by source for NOLC1 Gene

Compounds for NOLC1 Gene

(1) HMDB Compounds for NOLC1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(3) Novoseek inferred chemical compound relationships for NOLC1 Gene

Compound -log(P) Hits PubMed IDs
actinomycin d 36.3 1
tyrosine 9.5 4
serine 6.71 1
genes like me logo Genes that share compounds with NOLC1: view

Transcripts for NOLC1 Gene

Unigene Clusters for NOLC1 Gene

Nucleolar and coiled-body phosphoprotein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOLC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2:
SP3: - - - -
SP4: -
SP5:
SP6: - - -
SP7: -
SP8: - - - - - - -
SP9:

Relevant External Links for NOLC1 Gene

GeneLoc Exon Structure for
NOLC1
ECgene alternative splicing isoforms for
NOLC1

Expression for NOLC1 Gene

mRNA expression in normal human tissues for NOLC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOLC1 Gene

SOURCE GeneReport for Unigene cluster for NOLC1 Gene Hs.523238

genes like me logo Genes that share expressions with NOLC1: view

Orthologs for NOLC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOLC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOLC1 36
  • 99 (n)
  • 98.43 (a)
NOLC1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOLC1 36
  • 79 (n)
  • 76.49 (a)
NOLC1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOLC1 36
  • 82.69 (n)
  • 79.91 (a)
NOLC1 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nolc1 16
Nolc1 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOLC1 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOLC1 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nolc1 36
  • 77.17 (n)
  • 72.25 (a)
chicken
(Gallus gallus)
Aves NOLC1 37
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOLC1 37
  • 44 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia xNopp180 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC395027 36
zebrafish
(Danio rerio)
Actinopterygii nolc1 37
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dao-5 37
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP40 37
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11097 37
  • 29 (a)
OneToOne
Species with no ortholog for NOLC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOLC1 Gene

ENSEMBL:
Gene Tree for NOLC1 (if available)
TreeFam:
Gene Tree for NOLC1 (if available)

Paralogs for NOLC1 Gene

Pseudogenes.org Pseudogenes for NOLC1 Gene

genes like me logo Genes that share paralogs with NOLC1: view

No data available for Paralogs for NOLC1 Gene

Variants for NOLC1 Gene

Sequence variations from dbSNP and Humsavar for NOLC1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7897 -- 102,163,139(+) GACAT(G/T)AGTTT utr-variant-3-prime
rs12131 -- 102,163,519(+) GATAA(C/T)AGCTT utr-variant-3-prime
rs1049455 - 102,160,718(+) CTCTA(C/T)CTCTG missense, reference
rs1049466 -- 102,162,306(+) TGATC(C/G)GAGAC utr-variant-3-prime
rs1057950 -- 102,157,513(+) TCCAG(A/T)GATGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for NOLC1 Gene

Variant ID Type Subtype PubMed ID
nsv895968 CNV Loss 21882294

Relevant External Links for NOLC1 Gene

HapMap Linkage Disequilibrium report
NOLC1

Disorders for NOLC1 Gene

(1) Novoseek inferred disease relationships for NOLC1 Gene

Disease -log(P) Hits PubMed IDs
response acute phase 54.8 1

Relevant External Links for NOLC1

Genetic Association Database (GAD)
NOLC1
Human Genome Epidemiology (HuGE) Navigator
NOLC1
genes like me logo Genes that share disorders with NOLC1: view

No data available for UniProtKB/Swiss-Prot for NOLC1 Gene

Publications for NOLC1 Gene

  1. Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis. (PMID: 7657714) Pai C.-Y. … Yeh N.-H. (J. Cell Sci. 1995) 2 3 4 23
  2. Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization. (PMID: 10567578) Chen H.-K. … Yeh N.-H. (Mol. Cell. Biol. 1999) 2 3 4 23
  3. The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+. (PMID: 9016786) Chen H.-K. … Yeh N.-H. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  4. Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130. (PMID: 8630004) Pai C.-Y. … Yeh N.-H. (Biochem. Biophys. Res. Commun. 1996) 3 4 23
  5. Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor. (PMID: 8972203) Miau L.H. … Lee S.C. (Mol. Cell. Biol. 1997) 3 23

Products for NOLC1 Gene

Sources for NOLC1 Gene

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