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NOLC1 Gene

protein-coding   GIFtS: 57
GCID: GC10P103902

Nucleolar And Coiled-Body Phosphoprotein 1

  See NOLC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleolar And Coiled-Body Phosphoprotein 11 2     NOPP1302
Hepatitis C Virus NS5A-Transactivated Protein 132 3     P1302
Nucleolar 130 KDa Protein2 3     HCV NS5A Trans-Regulated Protein 132
Nucleolar Phosphoprotein P1302 3     Nucleolar And Coiled-Body Phosphprotein 12
140 KDa Nucleolar Phosphoprotein2 3     Nucleolar Protein P1302
NS5ATP132 3     KIAA00353
HCV NS5A-Transactivated Protein 132 3     Nopp1403
NOPP1402 5     p1305

External Ids:    HGNC: 156081   Entrez Gene: 92212   Ensembl: ENSG000001661977   OMIM: 6023945   UniProtKB: Q149783   

Export aliases for NOLC1 gene to outside databases

Previous GC identifers: GC10P102805 GC10P103145 GC10P104043 GC10P103576 GC10P097544


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NOLC1 Gene:
NOLC1 (nucleolar and coiled-body phosphoprotein 1) is a protein-coding gene. Diseases associated with NOLC1 include hepatitis c, and hepatitis c virus. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot: NOLC1_HUMAN, Q14978
Function: Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the
fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities.
May play an important role in transcription catalyzed by RNA polymerase I

Gene Wiki entry for NOLC1 (Nucleolar phosphoprotein p130) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOLC1 gene promoter:
         Pax-5   IRF-1   E47   AREB6   Max   E2F-1   E2F   Hand1   c-Myb   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NOLC1 promoter sequence
   Search Chromatin IP Primers for NOLC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOLC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.32

NOLC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOLC1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P103902:  view genomic region     (about GC identifiers)

Start:
103,911,933 bp from pter      End:
103,923,627 bp from pter
Size:
11,695 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NOLC1_HUMAN, Q14978 (See protein sequence)
Recommended Name: Nucleolar and coiled-body phosphoprotein 1  
Size: 699 amino acids; 73603 Da
Subunit: Interacts with RNA polymerase I 194 kDa subunit (RPA194) and with casein kinase-II
Secondary accessions: Q15030 Q5VV70 Q9BUV3
Alternative splicing: 3 isoforms:  Q14978-1   Q14978-2   Q14978-3   

Explore the universe of human proteins at neXtProt for NOLC1: NX_Q14978

Explore proteomics data for NOLC1 at MOPED

Post-translational modifications: 

  • Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. There is evidence
    suggesting that CDK1 kinase phosphorylates p130 at the M-phase1
  • Ubiquitination2 at Lys33, Lys59
  • Modification sites at PhosphoSitePlus

  • See NOLC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001271317.1  NP_001271318.1  NP_004732.2  

    ENSEMBL proteins: 
     ENSP00000474710   ENSP00000473910   ENSP00000475080   ENSP00000474924   ENSP00000473927  
     ENSP00000474140   ENSP00000359024   ENSP00000385410   ENSP00000473835  

    NOLC1 Human Recombinant Protein Products:

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    Novus Biologicals NOLC1 Protein
    Novus Biologicals NOLC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NOLC1

     
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    antibodies-online proteins for NOLC1 (3 products) 

     
    antibodies-online peptides for NOLC1

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    antibodies-online antibodies for NOLC1 (41 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006594 LisH_dimerisation
     IPR007718 SRP40_C

    Graphical View of Domain Structure for InterPro Entry Q14978

    ProtoNet protein and cluster: Q14978

    2 Blocks protein domains:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB007718 SRP40


    UniProtKB/Swiss-Prot: NOLC1_HUMAN, Q14978
    Similarity: Contains 1 LisH domain


    Find genes that share domains with NOLC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOLC1_HUMAN, Q14978
    Function: Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the
    fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities.
    May play an important role in transcription catalyzed by RNA polymerase I

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17620599
    GO:0005524ATP binding IEA--
    GO:0005525GTP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NOLC1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NOLC1:
     Decreased viability of wild-ty  Increased cell death in breast 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NOLC1

    miRNA
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    miRTarBase miRNAs that target NOLC1:
    hsa-mir-365a-3p (MIRT044030), hsa-let-7e-5p (MIRT051504), hsa-mir-375 (MIRT019859), hsa-mir-423-5p (MIRT038083), hsa-mir-324-3p (MIRT042908), hsa-mir-484 (MIRT042221), hsa-mir-155-5p (MIRT020682), hsa-let-7b-5p (MIRT032259), hsa-mir-98-5p (MIRT027538), hsa-let-7a-5p (MIRT052391), hsa-mir-195-5p (MIRT044865), hsa-mir-615-3p (MIRT039653), hsa-mir-378a-3p (MIRT043949), hsa-mir-222-3p (MIRT046772)

    Block miRNA regulation of human, mouse, rat NOLC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NOLC1 (see all 15):
    hsa-miR-3163 hsa-miR-3166 hsa-miR-513a-3p hsa-miR-575 hsa-miR-3065-5p hsa-miR-181a-2* hsa-miR-3647-3p hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidNOLC1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOLC1_HUMAN, Q14978: Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At
    telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to
    nucleoli at the early G1-phase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm ----
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0015030Cajal body IEA--

    Find genes that share ontologies with NOLC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOLC1
    Interactions:

        GeneGlobe Interaction Network for NOLC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOLC1 (Q149781, 2, 3 ENSP000003590244) via UniProtKB, MINT, STRING, and/or I2D (see all 737)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB1P494071, 3, ENSP000003771414EBI-396155,EBI-743313 I2D: score=2 STRING: ENSP00000377141
    ARRB2P321211, 3, ENSP000002692604EBI-396155,EBI-714559 I2D: score=2 STRING: ENSP00000269260
    CSNK2BP678703, ENSP000003650254I2D: score=3 STRING: ENSP00000365025
    ENSG00000224774P678703, ENSP000004156154I2D: score=3 STRING: ENSP00000415615
    ENSG00000206406P678703I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing TAS7657714
    GO:0007000nucleolus organization IEA--
    GO:0007049cell cycle TAS7657714
    GO:0007067mitosis TAS7657714

    Find genes that share ontologies with NOLC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOLC1

    1 HMDB Compound for NOLC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for NOLC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actinomycin d 36.3 1 7657714 (1)
    tyrosine 9.5 6 2110361 (2), 7929090 (1), 8843705 (1)
    serine 6.71 1 8972203 (1)



    Find genes that share compounds with NOLC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOLC1 gene (3 alternative transcripts): 
    NM_001284388.1  NM_001284389.1  NM_004741.4  

    Unigene Cluster for NOLC1:

    Nucleolar and coiled-body phosphoprotein 1
    Hs.523238  [show with all ESTs]
    Unigene Representative Sequence: NM_004741
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000605788 ENST00000464969 ENST00000488254 ENST00000603946 ENST00000461421
    ENST00000476468 ENST00000370007 ENST00000477977 ENST00000405356(uc001kuo.2 uc001kup.2 uc001kuq.2 uc009xxb.1 uc001kur.2)
    ENST00000603742
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NOLC1 (see all 15):
    hsa-miR-3163 hsa-miR-3166 hsa-miR-513a-3p hsa-miR-575 hsa-miR-3065-5p hsa-miR-181a-2* hsa-miR-3647-3p hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidNOLC1 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NOLC1
      QuantiFast Probe-based Assays in human, mouse, rat NOLC1

    Additional mRNA sequence: 

    AK056755.1 AK225101.1 AK314363.1 AY820769.1 BC001883.1 BC006769.2 D21262.1 L37710.1 
    Z34289.1 

    19 DOTS entries:

    DT.95375575  DT.95375581  DT.100887542  DT.454013  DT.100887523  DT.92453349  DT.95264724  DT.100031741 
    DT.100758167  DT.100887529  DT.101958343  DT.102833293  DT.121256181  DT.100887513  DT.92453356  DT.100887538 
    DT.86855693  DT.95149496  DT.99991864 

    Selected AceView cDNA sequences (see all 660):

    AI341272 BQ953323 AL551908 AW139816 BM855124 CA454523 BE794057 CN480233 
    BE672358 CA416287 AU143327 CB143836 BM849059 BI093466 AA721269 AA983639 
    BM970463 AI887878 BM015893 AW404500 BI860252 BU184808 AA865007 CA413580 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NOLC1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                          -                                                                     
    SP2:                                                                                                                                                
    SP3:                          -     -     -                                   -                                                                     
    SP4:                                                                          -                                                                     
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for NOLC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOLC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAAAAGTTC
    NOLC1 Expression
    About this image


    NOLC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
    NOLC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOLC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523238
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOLC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NOLC1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nolc15 nucleolar and coiled-body phosphoprotein 1   --   19 (38.75 cM) 46075863 
    chicken
    (Gallus gallus)
    Aves NOLC16
    nucleolar and coiled-body phosphoprotein 1
    47(a)
    1 ↔ 1
    6(16318282-16329867)
    lizard
    (Anolis carolinensis)
    Reptilia NOLC16
    nucleolar and coiled-body phosphoprotein 1
    44(a)
    1 ↔ 1
    GL343196.1(690910-714043)
    African clawed frog
    (Xenopus laevis)
    Amphibia xNopp1802 nucleolar phosphoprotein 73.57(n)    X88927.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nolc16
    nucleolar and coiled-body phosphoprotein 1
    27(a)
    1 ↔ 1
    13(4649847-4669031) ENSDARG00000024561
    worm
    (Caenorhabditis elegans)
    Secernentea dao-56
    Protein DAO-5, isoform a (dao-5) mRNA, complete cd...
    25(a)
    1 ↔ 1
    I(10187515-10190896) WBGene00000931
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRP406
    Nucleolar, serine-rich protein with a role in prer...
    35(a)
    1 ↔ 1
    XI(612665-613885) YKR092C


    ENSEMBL Gene Tree for NOLC1 (if available)
    TreeFam Gene Tree for NOLC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOLC1 gene

    Find genes that share paralogs with NOLC1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for NOLC1
    PGOHUM00000245641 PGOHUM00000249807 PGOHUM00000241184


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOLC1 (see all 323)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400751211,2
    --103910688(+) TCTCCC/TGCCTC 1 -- us2k10--------
    rs1872824861,2
    --103911043(+) TGGCTA/CATTTT 1 -- us2k10--------
    rs1152806881,2
    F--103911353(+) TGATAC/TTGGAG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1917460011,2
    --103911636(+) AGTCTA/GGAGGC 1 -- us2k10--------
    rs171143931,2
    C,F--103911695(+) TGAAGG/AGCGAG 1 -- us2k13Minor allele frequency- A:0.10MN EA 476
    rs70749121,2
    C,F,H--103911763(+) TGTTCG/TAGCCC 1 -- us2k110Minor allele frequency- T:0.02NS EA NA WA 1202
    rs564124421,2
    C,F--103911970(+) GCGATA/TCGCGT 1 -- ut511Minor allele frequency- T:0.02NA 120
    rs171143971,2
    C,F,H--103912003(+) TTTCCC/GGTCTA 1 -- ut5111Minor allele frequency- G:0.09NA NS EA WA CSA 802
    rs171144011,2
    C,F,H--103912015(+) CCTACC/TTCTGA 1 -- ut51 tfbs311Minor allele frequency- T:0.15NA NS EA WA CSA 686
    rs1174435951,2
    F--103912079(+) GGCGCA/GATGAC 1 -- ut511Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for NOLC1 (103911933 - 103923627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NOLC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895968CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOLC1
    DNA2.0 Custom Variant and Variant Library Synthesis for NOLC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602394    OMIM disorders: --

    3 diseases for NOLC1:    
    About MalaCards
    hepatitis c    hepatitis c virus    hepatitis


    Find genes that share disorders with NOLC1           About GenesLikeMe

    1 Novoseek inferred disease relationship for NOLC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    response acute phase 54.8 1 12167624 (1)

    Genetic Association Database (GAD): NOLC1
    Human Genome Epidemiology (HuGE) Navigator: NOLC1 (1 document)

    Export disorders for NOLC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOLC1 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with NOLC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis. (PubMed id 7657714)1, 2, 3, 9 Pai C.-Y.... Yeh N.-H. (J. Cell Sci. 1995)
    2. Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization. (PubMed id 10567578)1, 2, 3, 9 Chen H.-K.... Yeh N.-H. (Mol. Cell. Biol. 1999)
    3. The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+. (PubMed id 9016786)1, 2, 9 Chen H.-K. and Yeh N.-H. (Biochem. Biophys. Res. Commun. 1997)
    4. Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130. (PubMed id 8630004)1, 2, 9 Pai C.-Y. and Yeh N.-H. (Biochem. Biophys. Res. Commun. 1996)
    5. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)1, 2 Choudhary C.... Mann M. (Science 2009)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    10. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9221 HGNC: 15608 AceView: NOLC1 Ensembl:ENSG00000166197 euGenes: HUgn9221
    ECgene: NOLC1 H-InvDB: NOLC1

    (According to HUGE)
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    HUGE: KIAA0035

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NOLC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOLC1 gene:
    Search GeneIP for patents involving NOLC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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