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NOP10 Gene

protein-coding GIFtS: 50

GC15M032422

NOP10 ribonucleoprotein homolog (yeast)
(Previous names: nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NOLA3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC70651 ^¹, ²
NOLA3 ^², ³, ⁵
NOP10P ^¹, ²

Descriptions
NOP10 ribonucleoprotein homolog (yeast) ^²
Nucleolar protein 10 ^³
Nucleolar protein family A member 3 ^³
homolog of yeast Nop10p ^²
nucleolar protein family A, member 3 ^²
nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs) ^¹, ²
snoRNP protein NOP10 ^³

External Ids
HGNC: 14378¹
Entrez Gene: 55505²
UniProtKB: Q9NPE3³
Ensembl: ENSG00000182117⁷

Search outside databases for aliases for NOP10 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NOP10:

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family.

snoRNPs are involved in various aspects of rRNA processing and modification and have been

classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and

NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of

nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA

pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP

proteins are also components of the telomerase complex. This gene encodes a protein related to

Saccharomyces cerevisiae Nop10p. [provided by RefSeq]

UniProtKB/Swiss-Prot: NOP10_HUMAN, Q9NPE3

Function: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small

nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.

This involves the isomerization of uridine such that the ribose is subsequently attached to C5,

instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which

may serve to stabilize the conformation of rRNAs. May also be required for correct processing or

intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT)

holoenzyme

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14-q15 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q14-q15

NOP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M032422: (about GC identifiers)

Start:	32,421,209 bp from pter
End:	32,422,654 bp from pter
Size:	1,446 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NOP10_HUMAN, Q9NPE3 (See protein sequence)

Recommended Name: H/ACA ribonucleoprotein complex subunit 3

Size: 64 amino acids; 7706 Da

Subunit: Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains

NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic

subunit. The complex contains a stable core formed by binding of one or two NOP10-DKC1

heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA

small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA

substrate. During assembly, the complex contains NAF1 instead of GAR1/NOLA1. The complex also

interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs.

Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with

NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2,

SIP1/GEMIN2, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or

SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component

of the telomerase holoenzyme complex at least composed of TERT, DKC1, WDR79/TCAB1, NOP10, NHP2,

GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC)

Subcellular location: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies

(coiled bodies)

REFSEQ proteins: NP_061118.1

ENSEMBL proteins:

ENSP00000332198

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (NOLA3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005732	small nucleolar ribonucleoprotein complex	TAS	9843512

About this table

Antibodies for NOP10:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for NOP10

Assays for NOP10:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NPE3

ProtoNet protein and cluster: Q9NPE3

1 Blocks protein family: IPB007264 Nucleolar RNA-binding protein Nop10p

UniProtKB/Swiss-Prot: NOP10_HUMAN, Q9NPE3

Similarity: Belongs to the NOP10 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NOP10)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC063023

Applied Biosystems Silencer® siRNAs for NOP10

Sigma-Aldrich siRNA for NOP10

Sigma-Aldrich shRNA for NOP10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018648
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018648
untagged cDNA clones in CMV expression vector (see all 2): BC063023

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018648

UniProtKB/Swiss-Prot: NOP10_HUMAN, Q9NPE3

Function: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small

nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.

This involves the isomerization of uridine such that the ribose is subsequently attached to C5,

instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which

may serve to stabilize the conformation of rRNAs. May also be required for correct processing or

intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT)

holoenzyme

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	9843512
GO:0005515	protein binding	IPI	16601202

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for NOP10

5/9 Interacting proteins for NOP10 (ENSP00000332198³) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DKC1	ENSP00000358563³	STRING (score=.974)
GAR1	ENSP00000226796³	STRING (score=.974)
NHP2	ENSP00000274606³	STRING (score=.968)
TERT	ENSP00000309572³	STRING (score=.876)
FBL	ENSP00000221801³	STRING (score=.781)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001522	pseudouridine synthesis	NAS	9843512
GO:0006364	rRNA processing	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NOP10
1 Novoseek chemical compound relationship for NOP10 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pseudouridine	85.00	3	17855403 (1), 17412831 (1), 16373493 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NOP10)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC063023

Sigma-Aldrich siRNA for NOP10

Sigma-Aldrich shRNA for NOP10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018648

REFSEQ mRNAs for NOP10 gene:

NM_018648.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018648

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018648
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018648
                                 untagged cDNA clones in CMV expression vector (see all 2): BC063023

Additional cDNA sequence:

AB043104.1 BC008886.2 BC063023.1 CR612859.1

9 DOTS entries:

DT.319408 DT.121064740 DT.91759139 DT.95273853 DT.86854773 DT.91759143 DT.92325594 DT.121064739

DT.97867251

24/335 AceView cDNA sequences (see all 335 ):

BQ438156 BM855633 D59910 BP431793 CR612859 BE261748 AA112121 AA156862

AA319189 AA083998 AA934691 D80676 AA398357 AA905911 AA022749 BE877608

CA453345 AI718796 BC008886 W84570 BU728962 AA781774 AA371607 BM916715

Unigene Cluster for NOP10:

NOP10 ribonucleoprotein homolog (yeast)

Hs.14317 [show with all ESTs]

Unigene Representative Sequence: CF596384

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000328848

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NOP10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NOP10

¹ / ²

4 probe-sets matching NOP10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
74609_at²	U95-D	2	1.00	0.97	0.96	1.03	--	--	--	--	--
91722_at²	U95-E	2	1.00	0.91	0.94	0.97	--	--	--	--	--
217962_at²	U133-A	2	1.00	0.95	--	--	--	--	--	--	--
217962_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGGCATCAC

SOURCE GeneReport for Unigene cluster: Hs.14317

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NOP10 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NOP10¹	--	NOP10 ribonucleoprotein homolog (yeast)	90.1(n) 96.87(a)	607299 XM_843924.1 XP_849017.1
chimpanzee (Pan troglodytes)	NOP10¹	--	NOP10 ribonucleoprotein homolog (yeast)	99.48(n) 100(a)	746535 XM_001165865.1 XP_001165865.1
cow (Bos taurus)	NOP10¹	--	NOP10 ribonucleoprotein homolog (yeast)	91.67(n) 95.31(a)	616675 XM_868763.2 XP_873856.1
rat (Rattus norvegicus)	Nola3¹	--	nucleolar protein family A, member 3	94.79(n) 100(a)	691534 XM_001078710.1 XP_001078710.1
mouse (Mus musculus)	Nop10^{1, 5}	2⁵	NOP10 ribonucleoprotein homolog (yeast)^{1, 5}	94.27(n)¹ 100(a)¹	66181¹ NM_025403.2¹ NP_079679.1¹ AK004120⁵ AK012875⁵ (see all 7)

About this table Species with no ortholog for NOP10

ENSEMBL Gene Tree for NOP10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NOP10 gene

ENSG00000198923²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/29 NCBI SNPs in NOP10 are shown (see all 29 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 31)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs3063^1,2	A,C,F,H	32421325(+)	`AGCATA/GATCAA`	1	--	ut3¹		5	MN EU EA	492
	rs2169480^1,2	A,C,F,H	32422661(+)	`CCTGCA/GTAACC`	1	--	ng3¹ tfbs³		12	EU EA WA	1258
--	rs1045204^1,2	A,C,F	32421430(-)	`TGCCAC/TCTGTT`	1	--	ut3¹ ese³		1	MN	184
	rs347838^1,2	A,C,F	32420903(+)	`TGTCTG/ATAATA`	1	--	ng5¹		4	EA NA	152
	rs1045238^1,2	A,F	32421416(-)	`CCTCGG/CAGACT`	1	--	ut3¹		1	MN	184
--	rs1045194^1,2	A,C	32421431(-)	`CTGCCA/GCCTGT`	1	--	ut3¹ ese³		1	MN	184
--	rs7173^1,2	C	32421312(+)	`ATTGCC/TTCACA`	1	--	ut3¹ ese³		1	MN	184
--	rs15117^1,2	F	32421304(+)	`CCACCA/TTGATT`	1	--	ut3¹		1	MN	184
--	rs12818^1,2	C	32421311(+)	`GATTGC/TCTCAC`	1	--	ut3¹ ese³		1	MN	184
	rs422388^1,2	A,C,F,H	32421616(-)	`ATTCTG/CTGTTC`	1	--	int¹		4	EU EA WA	412

About this table

HapMap Linkage Disequilibrium images for NOP10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606471 disorders: 224230

UniProtKB/Swiss-Prot: NOP10_HUMAN, Q9NPE3

Defects in NOP10 are a cause of dyskeratosis congenita autosomal recessive (ARDKC)

[MIM:224230]. ARDKC is a rare, progressive bone marrow failure syndrome characterized by the triad

of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Early mortality is

often associated with bone marrow failure, infections, fatal pulmonary complications, or

malignancy

1 Novoseek disease relationship for NOP10 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dyskeratosis congenita	94.32	3	18239083 (1), 18989882 (1), 18252230 (1)

About this table

Human Genome Epidemiology Navigator: NOP10 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/30 PubMed articles for NOP10 gene (see all 30 ):

Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. (PubMed id 11074001)^{1, 2, 3, 4} Pogacic V.... Filipowicz W. (2000)
Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10. (PubMed id 17507419)^{1, 3, 4} Walne A.J....Dokal I. (2007)
hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase. (PubMed id 16601202)^{3, 4} Hoareau-Aveilla C....Henry Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins. (PubMed id 15044956)^{3, 4} Wang C. and Meier U.T. (2004)
Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. (PubMed id 9843512)^{2, 3} Henras A....Caizergues-Ferrer M. (1998)
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. (PubMed id 15814878)^{1, 3} Yamaguchi H.... Young N.S. (2005)
A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. (PubMed id 19179534)⁴ Venteicher A.S.... Artandi S.E. (2009)
Nucleolar proteome dynamics. (PubMed id 15635413)³ Andersen J.S....Mann M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55505	HGNC: 14378	AceView: NOLA3	Ensembl:ENSG00000182117	euGenes: HUgn55505
ECgene: NOP10	H-InvDB: NOP10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for NOP10
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NOP10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NOP10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NOP10		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NOP10		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NOLA3)
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Search Novus for antibodies for NOP10

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NOP10 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for NOP10

Summaries
for NOP10

Genomic Location
for NOP10

Proteins
for NOP10

Protein Domains/
Families
for NOP10

Gene Function
for NOP10

Pathways & Interactions
for NOP10

Drugs & Compounds
for NOP10

Transcripts
for NOP10

Expression
for NOP10

Orthologs
for NOP10

Paralogs
for NOP10

SNPs/Variants
for NOP10

Disorders & Mutations
for NOP10

Medical News
for NOP10

Publications
for NOP10

Search for NOP10

Genome Databases showing NOP10

Other Databases showing NOP10

Specialized Databases showing NOP10

Licensable Technologies
for NOP10

Services
for NOP10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NOP10 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor NOP10

Summariesfor NOP10

Genomic Locationfor NOP10

Proteinsfor NOP10

Protein Domains/Familiesfor NOP10

Gene Functionfor NOP10

Pathways & Interactionsfor NOP10

Drugs & Compoundsfor NOP10

Transcriptsfor NOP10

Expression for NOP10

Orthologsfor NOP10

Paralogsfor NOP10

SNPs/Variantsfor NOP10

Disorders & Mutationsfor NOP10

Medical Newsfor NOP10

Publicationsfor NOP10

Search for NOP10

Genome Databases showing NOP10

Other Databases showing NOP10

Specialized Databases showing NOP10

Licensable Technologiesfor NOP10

Servicesfor NOP10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NOP10

Summaries
for NOP10

Genomic Location
for NOP10

Proteins
for NOP10

Protein Domains/
Families
for NOP10

Gene Function
for NOP10

Pathways & Interactions
for NOP10

Drugs & Compounds
for NOP10

Transcripts
for NOP10

Expression
for NOP10

Orthologs
for NOP10

Paralogs
for NOP10

SNPs/Variants
for NOP10

Disorders & Mutations
for NOP10

Medical News
for NOP10

Publications
for NOP10

Licensable Technologies
for NOP10

Services
for NOP10