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Aliases for NOL9 Gene

Aliases for NOL9 Gene

  • Nucleolar Protein 9 2 3 4
  • Polynucleotide 5-Kinase 2 3
  • EC 2.7.1.- 4
  • Grc3 3
  • NET6 3

External Ids for NOL9 Gene

Previous GeneCards Identifiers for NOL9 Gene

  • GC01M006520
  • GC01M005729

Summaries for NOL9 Gene

GeneCards Summary for NOL9 Gene

NOL9 (Nucleolar Protein 9) is a Protein Coding gene. GO annotations related to this gene include RNA binding and polynucleotide 5-hydroxyl-kinase activity.

UniProtKB/Swiss-Prot for NOL9 Gene

  • Polynucleotide 5-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5-kinase activities. Probably binds RNA.

Gene Wiki entry for NOL9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL9 Gene

Genomics for NOL9 Gene

Regulatory Elements for NOL9 Gene

Genomic Location for NOL9 Gene

Chromosome:
1
Start:
6,521,347 bp from pter
End:
6,554,598 bp from pter
Size:
33,252 bases
Orientation:
Minus strand

Genomic View for NOL9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL9 Gene

Proteins for NOL9 Gene

  • Protein details for NOL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SY16-NOL9_HUMAN
    Recommended name:
    Polynucleotide 5-hydroxyl-kinase NOL9
    Protein Accession:
    Q5SY16
    Secondary Accessions:
    • Q2NL84
    • Q4VBY3
    • Q6P472
    • Q7L4D6
    • Q96EE0
    • Q9H5L4

    Protein attributes for NOL9 Gene

    Size:
    702 amino acids
    Molecular mass:
    79323 Da
    Quaternary structure:
    • Interacts with PELP1, WDR18 and SENP3.
    SequenceCaution:
    • Sequence=BAB15611.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NOL9 Gene

Proteomics data for NOL9 Gene at MOPED

Post-translational modifications for NOL9 Gene

  • Ubiquitination at Lys 651 and Lys 670
  • Modification sites at PhosphoSitePlus

Other Protein References for NOL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOL9 Gene

Domains & Families for NOL9 Gene

Protein Domains for NOL9 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for NOL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5SY16

UniProtKB/Swiss-Prot:

NOL9_HUMAN :
  • Belongs to the Clp1 family. NOL9/GRC3 subfamily.
Family:
  • Belongs to the Clp1 family. NOL9/GRC3 subfamily.
genes like me logo Genes that share domains with NOL9: view

No data available for Gene Families for NOL9 Gene

Function for NOL9 Gene

Molecular function for NOL9 Gene

UniProtKB/Swiss-Prot Function:
Polynucleotide 5-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5-kinase activities. Probably binds RNA.

Enzyme Numbers (IUBMB) for NOL9 Gene

Gene Ontology (GO) - Molecular Function for NOL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding TAS 21063389
GO:0005525 GTP binding --
GO:0051731 polynucleotide 5-hydroxyl-kinase activity IDA 21063389
genes like me logo Genes that share ontologies with NOL9: view
genes like me logo Genes that share phenotypes with NOL9: view

Animal Model Products

miRNA for NOL9 Gene

miRTarBase miRNAs that target NOL9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOL9

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NOL9 Gene

Localization for NOL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL9 Gene

Nucleus. Nucleus, nucleolus. Note=Colocalizes with pre-60S rRNP particles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOL9 Gene COMPARTMENTS Subcellular localization image for NOL9 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NOL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005730 nucleolus TAS 21063389
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NOL9: view

Pathways & Interactions for NOL9 Gene

SuperPathways for NOL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000460 maturation of 5.8S rRNA IMP 21063389
GO:0006396 RNA processing IBA --
GO:0006777 Mo-molybdopterin cofactor biosynthetic process --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with NOL9: view

No data available for Pathways by source and SIGNOR curated interactions for NOL9 Gene

Drugs & Compounds for NOL9 Gene

No Compound Related Data Available

Transcripts for NOL9 Gene

Unigene Clusters for NOL9 Gene

Nucleolar protein 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOL9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL9 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2:
SP3: -
SP4:

Relevant External Links for NOL9 Gene

GeneLoc Exon Structure for
NOL9
ECgene alternative splicing isoforms for
NOL9

Expression for NOL9 Gene

mRNA expression in normal human tissues for NOL9 Gene

Protein differential expression in normal tissues from HIPED for NOL9 Gene

This gene is overexpressed in Liver (20.9), Testis (9.2), and Fetal testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOL9 Gene



SOURCE GeneReport for Unigene cluster for NOL9 Gene Hs.59425

genes like me logo Genes that share expression patterns with NOL9: view

Protein tissue co-expression partners for NOL9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOL9 Gene

Orthologs for NOL9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOL9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOL9 35
  • 79.35 (n)
  • 75.69 (a)
NOL9 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOL9 35
  • 81.6 (n)
  • 77.95 (a)
NOL9 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nol9 35
  • 71.31 (n)
  • 61.97 (a)
Nol9 16
Nol9 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOL9 35
  • 99.29 (n)
  • 98.86 (a)
NOL9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nol9 35
  • 71.08 (n)
  • 62.89 (a)
oppossum
(Monodelphis domestica)
Mammalia NOL9 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves NOL9 35
  • 61.64 (n)
  • 61.99 (a)
NOL9 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOL9 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nol9 35
  • 58.26 (n)
  • 52.47 (a)
Str.6309 35
zebrafish
(Danio rerio)
Actinopterygii nol9 35
  • 51.27 (n)
  • 43.45 (a)
nol9 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8414 36
  • 13 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nol-9 36
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G11010 35
  • 48.3 (n)
  • 38.22 (a)
rice
(Oryza sativa)
Liliopsida Os01g0184000 35
  • 46.84 (n)
  • 37.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for NOL9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOL9 Gene

ENSEMBL:
Gene Tree for NOL9 (if available)
TreeFam:
Gene Tree for NOL9 (if available)

Paralogs for NOL9 Gene

Pseudogenes.org Pseudogenes for NOL9 Gene

genes like me logo Genes that share paralogs with NOL9: view

No data available for Paralogs for NOL9 Gene

Variants for NOL9 Gene

Sequence variations from dbSNP and Humsavar for NOL9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13513 -- 6,525,744(+) TGTTG(C/T)TAATA utr-variant-3-prime
rs747712 -- 6,527,625(+) AAAAC(A/T)AAACA intron-variant
rs908273 -- 6,528,544(+) AGCCT(A/G)GGGCA intron-variant
rs932112 -- 6,531,877(+) AGGAG(A/C/T)TATGT intron-variant
rs1064835 -- 6,525,479(-) AGGCC(A/G)ACCTG utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NOL9 Gene

Variant ID Type Subtype PubMed ID
nsv7880 CNV Gain+Loss 18304495
nsv831536 CNV Loss 17160897
nsv831647 CNV Loss 17160897

Variation tolerance for NOL9 Gene

Residual Variation Intolerance Score: 34.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL9 Gene

HapMap Linkage Disequilibrium report
NOL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL9 Gene

Disorders for NOL9 Gene

Relevant External Links for NOL9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOL9
genes like me logo Genes that share disorders with NOL9: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL9 Gene

Publications for NOL9 Gene

  1. Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing. (PMID: 21063389) Heindl K. … Martinez J. (EMBO J. 2010) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67

Products for NOL9 Gene

Sources for NOL9 Gene

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