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NOL9 Gene

protein-coding   GIFtS: 47
GCID: GC01M006581

Nucleolar Protein 9

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleolar Protein 91 2 3
Polynucleotide 5'-Kinase1 2
Grc32
NET62
Polynucleotide 5'-Hydroxyl-Kinase NOL92
EC 2.7.1.-3

External Ids:    HGNC: 262651   Entrez Gene: 797072   Ensembl: ENSG000001624087   UniProtKB: Q5SY163   

Export aliases for NOL9 gene to outside databases

Previous GC identifers: GC01M006520 GC01M005729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NOL9 Gene:
NOL9 (nucleolar protein 9) is a protein-coding gene. GO annotations related to this gene include RNA binding and polynucleotide 5'-hydroxyl-kinase activity.

UniProtKB/Swiss-Prot: NOL9_HUMAN, Q5SY16
Function: Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing
of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In
vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA

Gene Wiki entry for NOL9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOL9 gene promoter:
         MyoD   FOXO3   FOXO3b   AREB6   POU2F1   POU2F1a   FOXO3a   PPAR-gamma2   Hlf   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOL9 promoter sequence
   Search Chromatin IP Primers for NOL9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOL9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.31   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36.31

NOL9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOL9 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006581:  view genomic region     (about GC identifiers)

Start:
6,581,407 bp from pter      End:
6,614,658 bp from pter
Size:
33,252 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NOL9_HUMAN, Q5SY16 (See protein sequence)
Recommended Name: Polynucleotide 5'-hydroxyl-kinase NOL9  
Size: 702 amino acids; 79323 Da
Subunit: Interacts with PELP1, WDR18 and SENP3 (By similarity)
Sequence caution: Sequence=BAB15611.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q2NL84 Q4VBY3 Q6P472 Q7L4D6 Q96EE0 Q9H5L4

Explore the universe of human proteins at neXtProt for NOL9: NX_Q5SY16

Explore proteomics data for NOL9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys651, Lys670
  • Modification sites at PhosphoSitePlus

  • See NOL9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078930.3  
    ENSEMBL proteins: 
     ENSP00000366934  

    NOL9 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR010655 Pre-mRNA_cleavage_cplxII_Clp1

    Graphical View of Domain Structure for InterPro Entry Q5SY16

    ProtoNet protein and cluster: Q5SY16

    UniProtKB/Swiss-Prot: NOL9_HUMAN, Q5SY16
    Similarity: Belongs to the Clp1 family. NOL9/GRC3 subfamily


    Find genes that share domains with NOL9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOL9_HUMAN, Q5SY16
    Function: Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing
    of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In
    vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA

         Enzyme Number (IUBMB): EC 2.7.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005524ATP binding TAS--
    GO:0051731polynucleotide 5'-hydroxyl-kinase activity IDA--
         
    Find genes that share ontologies with NOL9           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NOL9:
     Decreased nuclei size in G2M  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOL9
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    miRNA
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    miRTarBase miRNAs that target NOL9:
    hsa-mir-30a-5p (MIRT049936), hsa-mir-744-5p (MIRT037648), hsa-mir-31-5p (MIRT049881)

    Block miRNA regulation of human, mouse, rat NOL9 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NOL9:
    hsa-miR-642a hsa-miR-4267 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidNOL9 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOL9_HUMAN, Q5SY16: Nucleus (By similarity). Nucleus, nucleolus. Note=Colocalizes with pre-60S rRNP particles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus TAS--

    Find genes that share ontologies with NOL9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOL9
    Interactions:

        Search GeneGlobe Interaction Network for NOL9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for NOL9 (Q5SY163 ENSP000003669344) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SUMO2P619563, ENSP000004059654I2D: score=1 STRING: ENSP00000405965
    LAS1LENSP000003639444STRING: ENSP00000363944
    MAF1ENSP000003186044STRING: ENSP00000318604
    RAD50ENSP000002653354STRING: ENSP00000265335
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000460maturation of 5.8S rRNA IMP--

    Find genes that share ontologies with NOL9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOL9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOL9 gene: 
    NM_024654.4  

    Unigene Cluster for NOL9:

    Nucleolar protein 9
    Hs.59425  [show with all ESTs]
    Unigene Representative Sequence: NM_024654
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377705(uc001ans.3 uc010nzs.2) ENST00000464383 ENST00000462798
    ENST00000460777 ENST00000464665
    miRNA
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    Block miRNA regulation of human, mouse, rat NOL9 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NOL9:
    hsa-miR-642a hsa-miR-4267 hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidNOL9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NOL9
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      QuantiTect SYBR Green Assays in human, mouse, rat NOL9
      QuantiFast Probe-based Assays in human, mouse, rat NOL9

    Additional mRNA sequence: 

    AK026976.1 AK091284.1 AK289653.1 BC009257.2 BC012439.1 BC063639.1 BC073860.1 BC094836.1 
    BC105095.1 BC110849.1 BC112278.1 BC143646.1 

    10 DOTS entries:

    DT.445929  DT.97842025  DT.91940181  DT.100761804  DT.91875388  DT.100725257  DT.91954283  DT.95110332 
    DT.95258026  DT.439414 

    Selected AceView cDNA sequences (see all 93):

    AI253686 AI075717 NM_024654 BX282410 BC063639 AA504370 T70351 BM852027 
    AA311866 BQ428156 CA432392 BI090843 CA435061 BC073860 AW769708 BF969522 
    BI869420 AX746895 CB984551 BI828678 BC009257 BE898310 BG256289 W93241 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NOL9    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                          -           -     -                                                         
    SP2:                                                                                                      
    SP3:                                                        -                                             
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for NOL9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOL9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NOL9 Expression
    About this image

    NOL9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOL9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.59425
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOL9 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nol91 , 5 nucleolar protein 91, 5 71.31(n)1
    61.97(a)1
      4 (82.84 cM)5
    740351  NM_001159599.11  NP_001153071.11 
     1520393215 
    chicken
    (Gallus gallus)
    Aves NOL91 nucleolar protein 9 61.64(n)
    61.99(a)
      770191  XM_001233521.3  XP_001233522.3 
    lizard
    (Anolis carolinensis)
    Reptilia NOL96
    nucleolar protein 9
    48(a)
    1 ↔ 1
    GL343320.1(1343097-1362156)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.63092 Transcribed sequence with weak similarity to protein more 78.63(n)    AL862852.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nol91 nucleolar protein 9 51.27(n)
    43.45(a)
      567715  XM_005162214.1  XP_005162271.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84146
    --
    13(a)
    1 ↔ 1
    2R(11986811-11990108)
    worm
    (Caenorhabditis elegans)
    Secernentea nol-96
    Protein NOL-9, isoform a
    21(a)
    1 ↔ 1
    IV(13422500-13429374) WBGene00010709
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G110101 AT5G11010 48.3(n)
    38.22(a)
      830968  NM_203036.1  NP_974765.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01840001 Os01g0184000 46.84(n)
    37.34(a)
      4325340  NM_001048765.1  NP_001042230.1 


    ENSEMBL Gene Tree for NOL9 (if available)
    TreeFam Gene Tree for NOL9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOL9 gene

    Find genes that share paralogs with NOL9           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NOL9
    PGOHUM00000241094


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOL9 (see all 813)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830373611,2
    --6582144(+) CTCACA/GCCTGT 1 -- ut310--------
    rs1868117001,2
    --6582213(+) AGCCTA/GGCCAA 1 -- ut310--------
    rs1912711211,2
    --6582246(+) TAAAAA/GTACAA 1 -- ut310--------
    rs1161247421,2
    C,F--6582269(+) AGTGTA/GGTGGC 1 -- ut311Minor allele frequency- G:0.04WA 118
    rs1493699921,2
    --6582274(+) AGTGGC/TGGGCG 1 -- ut310--------
    rs1437192531,2
    C--6582614(+) AGAAAA/CAAACA 1 -- ut310--------
    rs1842462831,2
    --6582658(+) GAATAC/GCTTCA 1 -- ut310--------
    rs1885764781,2
    --6582675(+) GCGCAC/GTGGCT 1 -- ut310--------
    rs1384025661,2
    --6582683(+) GCTCAC/TGCCTG 1 -- ut310--------
    rs111220491,2
    C,A,H--6582805(+) tgggcA/Gtggtg 1 -- ut31 ese36Minor allele frequency- G:0.08NA WA 12

    HapMap Linkage Disequilibrium report for NOL9 (6581407 - 6614658 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NOL9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831536CNV Loss17160897
    nsv831647CNV Loss17160897
    nsv7880CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOL9
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOL9 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with NOL9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing. (PubMed id 21063389)1, 2, 3 Heindl K. and Martinez J. (EMBO J. 2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. (PubMed id 22190735)1 Castle C.D....Denicourt C. (Mol. Biol. Cell 2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79707 HGNC: 26265 AceView: FLJ23323 Ensembl:ENSG00000162408 euGenes: HUgn79707
    ECgene: NOL9 H-InvDB: NOL9

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NOL9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOL9 gene:
    Search GeneIP for patents involving NOL9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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