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NOL8 Gene

protein-coding   GIFtS: 55
GCID: GC09M095059

Nucleolar Protein 8

(Previous name: chromosome 9 open reading frame 34)
(Previous symbol: C9orf34)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleolar Protein 81 2     Chromosome 9 Open Reading Frame 341
C9orf341 2 3     bA62C3.32
NOP1322 3 5     bA62C3.42
Nucleolar Protein Nop1322 3     

External Ids:    HGNC: 233871   Entrez Gene: 550352   Ensembl: ENSG000001980007   OMIM: 6115345   UniProtKB: Q76FK43   

Export aliases for NOL8 gene to outside databases

Previous GC identifers: GC09M090401 GC09M092139 GC09M094099 GC09M064737


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOL8 Gene:
NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al.,
2004 (PubMed 14660641)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NOL8 Gene:
NOL8 (nucleolar protein 8) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: NOL8_HUMAN, Q76FK4
Function: Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar
anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level
or in ribosome biogenesis in cancer cells

Gene Wiki entry for NOL8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOL8 gene promoter:
         Nkx3-1   Nkx3-1 v4   AP-1   HTF   Nkx3-1 v1   Nkx3-1 v2   FOXO4   Cart-1   Nkx3-1 v3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOL8 promoter sequence
   Search Chromatin IP Primers for NOL8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOL8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.31   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q22.32

NOL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOL8 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M095059:  view genomic region     (about GC identifiers)

Start:
95,059,640 bp from pter      End:
95,087,918 bp from pter
Size:
28,279 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NOL8_HUMAN, Q76FK4 (See protein sequence)
Recommended Name: Nucleolar protein 8  
Size: 1167 amino acids; 131616 Da
Subunit: Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the
interaction is RNA-dependent. Interacts with DDX47; the interaction is RNA-dependent
Sequence caution: Sequence=BAA91356.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91356.1; Type=Frameshift; Positions=1136; Sequence=BAB14229.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB15003.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Secondary accessions: Q5TCC7 Q5TCC8 Q5TCD3 Q5TCD5 Q5TCD6 Q5TCD7 Q76D35 Q7L3E2 Q9H586 Q9H795
Q9H7W7 Q9H9J6 Q9NWA4 Q9NWM4
Alternative splicing: 3 isoforms:  Q76FK4-1   Q76FK4-2   Q76FK4-4   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for NOL8: NX_Q76FK4

Explore proteomics data for NOL8 at MOPED

Post-translational modifications: 

  • Phosphorylated (Probable)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NOL8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243323.1  NP_060418.4  

    ENSEMBL proteins: 
     ENSP00000401177   ENSP00000439829   ENSP00000446265   ENSP00000441140   ENSP00000354115  
     ENSP00000439751   ENSP00000441300   ENSP00000440709   ENSP00000414112   ENSP00000415750  
     ENSP00000412471   ENSP00000390143   ENSP00000390791   ENSP00000388335   ENSP00000442666  
     ENSP00000442037   ENSP00000442596   ENSP00000440342   ENSP00000437615   ENSP00000444790  
     ENSP00000351723  

    NOL8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NOL8

     
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    NOL8 Assay Products:

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    Search eBioscience for ELISAs for NOL8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q76FK4

    ProtoNet protein and cluster: Q76FK4

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: NOL8_HUMAN, Q76FK4
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with NOL8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOL8_HUMAN, Q76FK4
    Function: Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar
    anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level
    or in ribosome biogenesis in cancer cells
    Induction: Up-regulated in diffuse-type gastric cancers

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI11073942
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NOL8           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for NOL8:
     Decreased TP53 protein express  Decreased number of cells in m  Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOL8
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOL8

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOL8:
    hsa-mir-30a-5p (MIRT028453), hsa-mir-124-3p (MIRT022317), hsa-mir-1260b (MIRT052782), hsa-mir-186-5p (MIRT045291)

    Block miRNA regulation of human, mouse, rat NOL8 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NOL8:
    hsa-miR-181c hsa-miR-590-3p hsa-miR-181a hsa-miR-181d hsa-miR-548aa hsa-miR-4262 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidNOL8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NOL8

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOL8_HUMAN, Q76FK4: Nucleus, nucleolus. Note=Localizes in the nucleolar-organizing region during ribosome
    biogenesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with NOL8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOL8
    Interactions:

        Search GeneGlobe Interaction Network for NOL8

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for NOL8 (Q76FK43 ENSP000004011774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NIP7Q9Y2213, ENSP000002549404I2D: score=3 STRING: ENSP00000254940
    RRAGAQ7L5233, ENSP000003698994I2D: score=3 STRING: ENSP00000369899
    RRAGDQ9NQL23, ENSP000003584234I2D: score=2 STRING: ENSP00000358423
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=1 
    RRAGCQ9HB903, ENSP000003620924I2D: score=3 STRING: ENSP00000362092
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IMP14660641
    GO:0006364rRNA processing IMP16963496
    GO:0030307positive regulation of cell growth IMP14660641

    Find genes that share ontologies with NOL8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOL8

    1 HMDB Compound for NOL8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOL8 gene (2 alternative transcripts): 
    NM_001256394.1  NM_017948.5  

    Unigene Cluster for NOL8:

    Nucleolar protein 8
    Hs.442199  [show with all ESTs]
    Unigene Representative Sequence: NR_046106
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000442668(uc022bjw.1 uc022bjx.1) ENST00000545444 ENST00000463593
    ENST00000536593 ENST00000545558 ENST00000360868 ENST00000544867(uc010mqw.3)
    ENST00000535387 ENST00000542053 ENST00000477862 ENST00000432670(uc004arx.3)
    ENST00000434228(uc022bjy.1) ENST00000538802 ENST00000433029 ENST00000467230
    ENST00000421075 ENST00000445919 ENST00000411621
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate NOL8:
    hsa-miR-181c hsa-miR-590-3p hsa-miR-181a hsa-miR-181d hsa-miR-548aa hsa-miR-4262 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidNOL8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NOL8
    Predesigned siRNA for gene silencing in human, mouse, rat NOL8
    Clone
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    GenScript: all cDNA clones in your preferred vector: NOL8 (NM_017948)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL8
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOL8
      QuantiTect SYBR Green Assays in human, mouse, rat NOL8
      QuantiFast Probe-based Assays in human, mouse, rat NOL8

    Additional mRNA sequence: 

    AB105104.1 AB109030.1 AK000743.1 AK001049.1 AK022755.1 AK024245.1 AK024786.1 AK225322.1 
    AK297355.1 AK307408.1 BC008491.1 BC013788.1 BC035041.1 BC064942.1 BC146810.1 CR627363.1 
    NR_046106.1 

    20 DOTS entries:

    DT.442079  DT.100051214  DT.40248652  DT.75100967  DT.101983329  DT.121154371  DT.101983327  DT.213558 
    DT.100669262  DT.86854370  DT.91743590  DT.100788192  DT.101959145  DT.102820017  DT.102843399  DT.121231307 
    DT.40130813  DT.91962634  DT.97785813  DT.97810254 

    Selected AceView cDNA sequences (see all 174):

    AI207377 AU132683 BC008491 AL589437 AI624590 BU675236 CB111711 BF940559 
    BX481984 AA469116 AA580997 BC035041 BU164509 AI565157 AA678554 CR606273 
    AA357162 CA446250 CB131338 BU429357 AU124194 BU753944 BU753883 CR627363 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NOL8 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^
    SP1:                                -     -                 -     -     -           -     -     -     -     -     -     -     -     -     -                     
    SP2:                                                                                                                                                            
    SP3:                                                        -     -     -           -     -     -                                                               
    SP4:                                                                                                                                                            
    SP5:                                -     -     -           -     -     -           -     -     -                                                               

    ExUns: 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for NOL8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOL8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGGTTTAT
    NOL8 Expression
    About this image


    NOL8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    NOL8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOL8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442199

    UniProtKB/Swiss-Prot: NOL8_HUMAN, Q76FK4
    Tissue specificity: Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle

        Custom PCR Arrays for NOL8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NOL8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nol81 , 5 nucleolar protein 81, 5 77.28(n)1
    65.43(a)1
      13 (25.36 cM)5
    709301  NM_001271397.11  NP_001258326.11 
     496533505 
    chicken
    (Gallus gallus)
    Aves NOL81 nucleolar protein 8 56.67(n)
    46.09(a)
      415955  XM_004944506.1  XP_004944563.1 
    lizard
    (Anolis carolinensis)
    Reptilia NOL86
    nucleolar protein 8
    40(a)
    1 ↔ 1
    2(156289733-156312851)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.148132 Xenopus laevis transcribed sequence with weak similarity more 75.62(n)    BI447930.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nol86
    nucleolar protein 8
    34(a)
    1 ↔ 1
    22(10535145-10550838) ENSDARG00000044143
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142306
    --
    24(a)
    1 ↔ 1
    X(19598193-19600450)


    ENSEMBL Gene Tree for NOL8 (if available)
    TreeFam Gene Tree for NOL8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOL8 gene
    4 SIMAP similar genes for NOL8 using alignment to 13 protein entries:     NOL8_HUMAN (see all proteins):
    DKFZp686P12242    HNRNPD    CIRBP    RBMX

    Find genes that share paralogs with NOL8           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NOL8
    PGOHUM00000259922


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOL8 (see all 565)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11527581,2
    C,A--95059180(+) AGAGAC/TGGGGT 3 -- int17Minor allele frequency- T:0.00NA WA CSA 13
    rs1864927681,2
    --95059235(+) TGATCC/TGCCCG 3 -- int10--------
    rs109922981,2
    C,F--95059261(+) gtactG/Aagatt 3 -- int12Minor allele frequency- A:0.18WA 120
    rs1896209071,2
    C--95059289(+) CGCCCA/GGCCTA 3 -- int10--------
    rs1823469601,2
    --95059309(+) ATTTCA/TTACAG 3 -- int10--------
    rs1862091561,2
    C--95059358(+) GCAGGC/TTGGTT 3 -- int10--------
    rs727504741,2
    C,F--95059493(+) ATTGGT/GGTACA 3 -- int11Minor allele frequency- G:0.02EA 120
    rs7101621,2
    C,F,A,H--95059790(-) TTTTTT/AAATAA 3 -- ut31 nc-transcript-variant118Minor allele frequency- A:0.37NS NA MN EA PA EU CA WA CSA 8289
    rs7101631,2
    C,F,A,H--95059804(+) TTCATA/GTAAAC 3 -- ut31 nc-transcript-variantese336Minor allele frequency- N:0.00NA EA MN NS WA CSA 3396
    rs42985401,2
    C,F,H--95059833(+) CATTAG/CTTACT 3 -- ut31 nc-transcript-variantese36Minor allele frequency- C:0.02NS EA NA 658

    HapMap Linkage Disequilibrium report for NOL8 (95059640 - 95087918 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NOL8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893573CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOL8
    DNA2.0 Custom Variant and Variant Library Synthesis for NOL8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611534    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NOL8:
    Becker muscular dystrophy

    Find genes that share disorders with NOL8           About GenesLikeMe

    Genetic Association Database (GAD): NOL8
    Human Genome Epidemiology (HuGE) Navigator: NOL8 (1 document)

    Export disorders for NOL8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOL8 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with NOL8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PubMed id 14660641)1, 2, 9 Sekiguchi T....Nishimoto T. (J. Biol. Chem. 2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PubMed id 16963496)1, 2 Sekiguchi T.... Nishimoto T. (Nucleic Acids Res. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer. (PubMed id 15132771)1, 2 Jinawath N.... Nakamura Y. (Cancer Sci. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55035 HGNC: 23387 AceView: NOL8 Ensembl:ENSG00000198000 euGenes: HUgn55035
    ECgene: NOL8 H-InvDB: NOL8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NOL8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOL8 gene:
    Search GeneIP for patents involving NOL8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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