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Aliases for NOL8 Gene

Aliases for NOL8 Gene

  • Nucleolar Protein 8 2 3 5
  • Nucleolar Protein Nop132 3 4
  • C9orf34 3 4
  • NOP132 3 4
  • Chromosome 9 Open Reading Frame 34 2
  • BA62C3.3 3
  • BA62C3.4 3

External Ids for NOL8 Gene

Previous HGNC Symbols for NOL8 Gene

  • C9orf34

Previous GeneCards Identifiers for NOL8 Gene

  • GC09M090401
  • GC09M092139
  • GC09M094099
  • GC09M095059
  • GC09M064737

Summaries for NOL8 Gene

Entrez Gene Summary for NOL8 Gene

  • NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NOL8 Gene

NOL8 (Nucleolar Protein 8) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for NOL8 Gene

  • Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.

Gene Wiki entry for NOL8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL8 Gene

Genomics for NOL8 Gene

Regulatory Elements for NOL8 Gene

Enhancers for NOL8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G093110 2.1 FANTOM5 Ensembl ENCODE dbSUPER 30.8 -787.8 -787833 6.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 NINJ1 NOL8 PHF2 CARD19 SUSD3 LINC00475 IPPK WNK2 FGD3 FAM120A
GH09G092145 1.6 Ensembl ENCODE dbSUPER 29.8 +178.6 178604 3.5 HDGF CREB3L1 ARNT YBX1 ZNF2 ZBTB7B ZNF766 ZNF207 FOS KLF13 NOL8 MTND4P15 SPTLC1 MTCO3P29 LINC00475 LOC100128076 GC09M092145 ENSG00000236717
GH09G092607 1.4 Ensembl ENCODE dbSUPER 33.4 -284.2 -284199 5.6 PKNOX1 MLX ZNF195 FEZF1 THRB RAD21 RARA ZNF335 ZNF350 EGR2 PHF2 NOL8 LINC00475 CENPP ZNF484 IPPK CARD19 PIR58934 GC09P092539
GH09G092744 1.1 dbSUPER 42.5 -419.5 -419501 1.1 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF302 ZNF207 NOL8 PHF2 MTND4P15 CENPP SPTLC1 LINC00475 ZNF484 MTCO3P29 IPPK ECM2
GH09G091514 1.5 Ensembl ENCODE dbSUPER 17.8 +810.6 810571 1.7 FOXA2 PKNOX1 ATF1 CREB3L1 ARNT FEZF1 ZNF2 TCF12 ZNF766 CBX5 NOL8 MTND4P15 PIR33956 GC09P091563
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOL8 on UCSC Golden Path with GeneCards custom track

Promoters for NOL8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000237877 494 2201 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for NOL8 Gene

Chromosome:
9
Start:
92,297,358 bp from pter
End:
92,325,994 bp from pter
Size:
28,637 bases
Orientation:
Minus strand

Genomic View for NOL8 Gene

Genes around NOL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL8 Gene

Proteins for NOL8 Gene

  • Protein details for NOL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76FK4-NOL8_HUMAN
    Recommended name:
    Nucleolar protein 8
    Protein Accession:
    Q76FK4
    Secondary Accessions:
    • Q5TCC7
    • Q5TCC8
    • Q5TCD3
    • Q5TCD5
    • Q5TCD6
    • Q5TCD7
    • Q76D35
    • Q7L3E2
    • Q9H586
    • Q9H795
    • Q9H7W7
    • Q9H9J6
    • Q9NWA4
    • Q9NWM4

    Protein attributes for NOL8 Gene

    Size:
    1167 amino acids
    Molecular mass:
    131616 Da
    Quaternary structure:
    • Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the interaction is RNA-dependent. Interacts with DDX47; the interaction is RNA-dependent.
    SequenceCaution:
    • Sequence=BAA91356.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91356.1; Type=Frameshift; Positions=1136; Evidence={ECO:0000305}; Sequence=BAB14229.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15003.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL8 Gene

Post-translational modifications for NOL8 Gene

No data available for DME Specific Peptides for NOL8 Gene

Domains & Families for NOL8 Gene

Gene Families for NOL8 Gene

Suggested Antigen Peptide Sequences for NOL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL8: view

No data available for UniProtKB/Swiss-Prot for NOL8 Gene

Function for NOL8 Gene

Molecular function for NOL8 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated in diffuse-type gastric cancers.

Gene Ontology (GO) - Molecular Function for NOL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0005515 protein binding IPI 11073942
genes like me logo Genes that share ontologies with NOL8: view
genes like me logo Genes that share phenotypes with NOL8: view

Animal Models for NOL8 Gene

MGI Knock Outs for NOL8:
  • Nol8 tm1b(EUCOMM)Hmgu

Animal Model Products

miRNA for NOL8 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOL8 Gene

Localization for NOL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL8 Gene

Nucleus, nucleolus. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL8 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NOL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA,IEA 14660641
genes like me logo Genes that share ontologies with NOL8: view

Pathways & Interactions for NOL8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IMP 16963496
GO:1902570 protein localization to nucleolus IMP 16963496
genes like me logo Genes that share ontologies with NOL8: view

No data available for Pathways by source and SIGNOR curated interactions for NOL8 Gene

Drugs & Compounds for NOL8 Gene

(1) Drugs for NOL8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with NOL8: view

Transcripts for NOL8 Gene

Unigene Clusters for NOL8 Gene

Nucleolar protein 8:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - - - - -
SP2:
SP3: - - - - - -
SP4:
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - - - -
SP10:
SP11: - - - -
SP12: - - - -
SP13: - -
SP14:
SP15: -
SP16:

ExUns: 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NOL8 Gene

GeneLoc Exon Structure for
NOL8
ECgene alternative splicing isoforms for
NOL8

Expression for NOL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOL8 Gene

This gene is overexpressed in Monocytes (27.3), Serum (15.9), and Platelet (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL8 Gene



Protein tissue co-expression partners for NOL8 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOL8 Gene:

NOL8

SOURCE GeneReport for Unigene cluster for NOL8 Gene:

Hs.442199

mRNA Expression by UniProt/SwissProt for NOL8 Gene:

Q76FK4-NOL8_HUMAN
Tissue specificity: Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.

Evidence on tissue expression from TISSUES for NOL8 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with NOL8: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL8 Gene

Orthologs for NOL8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOL8 34 35
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia NOL8 34 35
  • 83.15 (n)
-- 35
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NOL8 34 35
  • 77.57 (n)
mouse
(Mus musculus)
Mammalia Nol8 34 16 35
  • 77.28 (n)
rat
(Rattus norvegicus)
Mammalia Nol8 34
  • 76.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NOL8 35
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOL8 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOL8 34 35
  • 56.67 (n)
lizard
(Anolis carolinensis)
Reptilia NOL8 35
  • 40 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14813 34
zebrafish
(Danio rerio)
Actinopterygii nol8 35
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14230 35
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for NOL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL8 Gene

ENSEMBL:
Gene Tree for NOL8 (if available)
TreeFam:
Gene Tree for NOL8 (if available)

Paralogs for NOL8 Gene

Pseudogenes.org Pseudogenes for NOL8 Gene

genes like me logo Genes that share paralogs with NOL8: view

No data available for Paralogs for NOL8 Gene

Variants for NOL8 Gene

Sequence variations from dbSNP and Humsavar for NOL8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000206376 -- 92,317,105(+) GTGCC(A/C)CCGGG intron-variant
rs1000207659 -- 92,323,136(+) GGAAT(A/G)TGGCA intron-variant, upstream-variant-2KB
rs1000263503 -- 92,325,752(+) CCAGA(G/T)AAAGT upstream-variant-2KB, utr-variant-5-prime
rs1000484012 -- 92,309,974(+) TCTGG(C/T)AGCTC intron-variant
rs1000558245 -- 92,319,165(+) GTGAT(C/G)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOL8 Gene

Variant ID Type Subtype PubMed ID
esv3621078 CNV loss 21293372
esv3891693 CNV gain 25118596
nsv1045165 CNV loss 25217958
nsv1046733 CNV gain 25217958

Variation tolerance for NOL8 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL8 Gene

Disorders for NOL8 Gene

Relevant External Links for NOL8

Genetic Association Database (GAD)
NOL8
Human Genome Epidemiology (HuGE) Navigator
NOL8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOL8

No disorders were found for NOL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL8 Gene

Publications for NOL8 Gene

  1. A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PMID: 14660641) Sekiguchi T. … Nishimoto T. (J. Biol. Chem. 2004) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PMID: 16963496) Sekiguchi T. … Nishimoto T. (Nucleic Acids Res. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for NOL8 Gene

Sources for NOL8 Gene

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