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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NOL8 Gene

protein-coding GIFtS: 52
GCID: GC09M095059

nucleolar protein 8

(Previous name: chromosome 9 open reading frame 34 )
(Previous symbol: C9orf34)

Explore 3 diseases affiliated with
NOL8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nucleolar Protein 8¹ ²		Nop132¹
C9orf34¹ ² ³		Chromosome 9 Open Reading Frame 34¹
NOP132² ³ ⁵		BA62C3.3¹
Nucleolar Protein Nop132² ³		BA62C3.4¹
FLJ20736¹

External Ids:	HGNC: 23387¹	Entrez Gene: 55035²	Ensembl: ENSG00000198000⁷	OMIM: 611534⁵	UniProtKB: Q76FK4³

ORGUL members:
	NONCODE:n406513

Export aliases for NOL8 gene to outside databases

Previous GC identifers: GC09M090401 GC09M092139 GC09M094099 GC09M064737

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOL8:

NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004

(PubMed 14660641)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: NOL8_HUMAN, Q76FK4

Function: Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring

protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome

biogenesis in cancer cells

Gene Wiki entry for NOL8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NOL8 gene promoter:
Nkx3-1 Nkx3-1 v4 AP-1 HTF Nkx3-1 v1 Nkx3-1 v2 FOXO4 Cart-1 Nkx3-1 v3 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NOL8 promoter sequence

Search SABiosciences Chromatin IP Primers for NOL8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOL8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.31 Ensembl cytogenetic band: 9q22.31 HGNC cytogenetic band: 9q22.32

NOL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOL8 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M095059: view genomic region (about GC identifiers)

Start:	95,059,640 bp from pter	End:	95,087,918 bp from pter
Size:	28,279 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NOL8_HUMAN, Q76FK4 (See protein sequence)

Recommended Name: Nucleolar protein 8

Size: 1167 amino acids; 131616 Da

Subunit: Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the

interaction is RNA-dependent. Interacts with DDX47; the interaction is RNA-dependent

Subcellular location: Nucleus, nucleolus. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis

Sequence caution: Sequence=BAA91356.1; Type=Frameshift; Positions=1136; Sequence=BAB14229.1; Type=Erroneous initiation;

Sequence=BAB15003.1; Type=Erroneous initiation;

Secondary accessions: Q5TCC7 Q5TCC8 Q5TCD3 Q5TCD5 Q5TCD6 Q5TCD7 Q76D35 Q7L3E2 Q9H586 Q9H795 Q9H7W7

Q9H9J6 Q9NWA4 Q9NWM4

Alternative splicing: 4 isoforms: Q76FK4-1 Q76FK4-2 Q76FK4-3 Q76FK4-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOL8: NX_Q76FK4

Post-translational modifications:

Phosphorylated (Probable)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q76FK4

NOL8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001243323.1 NP_060418.4

ENSEMBL proteins:

ENSP00000401177 ENSP00000439829 ENSP00000446265 ENSP00000441140 ENSP00000354115

ENSP00000439751 ENSP00000441300 ENSP00000440709 ENSP00000414112 ENSP00000415750

ENSP00000412471 ENSP00000390143 ENSP00000390791 ENSP00000388335 ENSP00000442666

ENSP00000442037 ENSP00000442596 ENSP00000440342 ENSP00000437615 ENSP00000444790

ENSP00000351723

Human Recombinant Protein Products for NOL8:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NOL8

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

NOL8 for ontologies About GeneDecksing

NOL8 Antibody Products:

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	Uscn ELISAs and CLIAs for NOL8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NOL8 for domains About GeneDecksing

2 InterPro domains/families:

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry Q76FK4

ProtoNet protein and cluster: Q76FK4

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: NOL8_HUMAN, Q76FK4

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NOL8_HUMAN, Q76FK4

Function: Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring

protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome

biogenesis in cancer cells

Induction: Up-regulated in diffuse-type gastric cancers

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	14660641

NOL8 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for NOL8:

Decreased TP53 protein express

Decreased number of cells in m

Decreased viability of wild-ty

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NOL8

miRNA Products:		OriGene 3'-UTR Clone: NOL8 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOL8
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate NOL8:
		hsa-miR-181c hsa-miR-590-3p hsa-miR-181a hsa-miR-181d hsa-miR-548aa hsa-miR-4262 hsa-miR-181b
		SwitchGear 3'UTR luciferase reporter plasmid: NOL8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOL8 (see all 7) OriGene shRNA RFP: NOL8 OriGene siRNA: NOL8
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL8 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL8 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL8

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NOL8

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for NOL8 (Q76FK4³ ENSP00000401177⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NIP7	Q9Y221³, ENSP00000254940⁴	I2D: score=3 STRING: ENSP00000254940
RRAGA	Q7L523³, ENSP00000369899⁴	I2D: score=3 STRING: ENSP00000369899
RRAGD	Q9NQL2³, ENSP00000358423⁴	I2D: score=2 STRING: ENSP00000358423
MED19	A0JLT2³, ENSP00000337340⁴	STRING: ENSP00000337340 I2D: score=1
RRAGC	Q9HB90³, ENSP00000362092⁴	I2D: score=3 STRING: ENSP00000362092

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006260	DNA replication	IMP	14660641
GO:0006364	rRNA processing	IMP	16963496
GO:0030307	positive regulation of cell growth	IMP	14660641

NOL8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NOL8

1 HMDB Compound for NOL8 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about NOL8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NOL8 gene (2 alternative transcripts):

NM_001256394.1 NM_017948.5

Unigene Cluster for NOL8:

Nucleolar protein 8

Hs.442199 [show with all ESTs]

Unigene Representative Sequence: NR_046106

18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):

ENST00000442668(uc022bjw.1 uc022bjx.1) ENST00000545444 ENST00000463593

ENST00000536593 ENST00000545558 ENST00000360868 ENST00000544867(uc010mqw.3)

ENST00000535387 ENST00000542053 ENST00000477862 ENST00000432670(uc004arx.3)

ENST00000434228(uc022bjy.1) ENST00000538802 ENST00000433029 ENST00000467230

ENST00000421075 ENST00000445919 ENST00000411621

miRNA Products:		OriGene 3'-UTR Clone: NOL8 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOL8
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate NOL8:
		hsa-miR-181c hsa-miR-590-3p hsa-miR-181a hsa-miR-181d hsa-miR-548aa hsa-miR-4262 hsa-miR-181b
		SwitchGear 3'UTR luciferase reporter plasmid: NOL8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against NOL8

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		GenScript: all cDNA clones in your preferred vector: NOL8 (NM_017948)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOL8

Additional cDNA sequence:

AB105104.1 AB109030.1 AK000743.1 AK001049.1 AK022755.1 AK024245.1 AK024786.1 AK225322.1

AK297355.1 AK307408.1 BC008491.1 BC013788.1 BC035041.1 BC064942.1 BC146810.1 CR627363.1

NR_046106.1

20 DOTS entries:

DT.442079 DT.100051214 DT.40248652 DT.75100967 DT.101983329 DT.121154371 DT.101983327 DT.213558

DT.100669262 DT.86854370 DT.91743590 DT.100788192 DT.101959145 DT.102820017 DT.102843399 DT.121231307

DT.40130813 DT.91962634 DT.97785813 DT.97810254

24/174 AceView cDNA sequences (see all 174):

AI624590 AU132683 AA469116 AA357162 CR606273 BC035041 AA580997 BU164509

BC008491 BX481984 CB111711 BU753944 BU675236 BU753883 CA446250 BU429357

AA678554 BQ182528 CR627363 AU124194 BC064942 BX484613 BM839376 CB131338

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NOL8 (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14	^
SP1:											-		-						-		-		-				-		-		-		-		-		-		-		-		-		-
SP2:
SP3:																			-		-		-				-		-		-
SP4:
SP5:											-		-		-				-		-		-				-		-		-

ExUns:	15a	·	15b	^	16	^	17a	·	17b	·	17c	^	18	^	19	^	20a	·	20b	^	21a	·	21b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for NOL8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NOL8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGGTTTAT

About this image
See NOL8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOL8

SOURCE GeneReport for Unigene cluster: Hs.442199

UniProtKB/Swiss-Prot: NOL8_HUMAN, Q76FK4

Tissue specificity: Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle

SABiosciences Custom PCR Arrays for NOL8

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NOL8 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nol8^{1 , 5}	nucleolar protein 8^{1, 5}	77.28(n)¹ 65.43(a)¹		13 (25.36 cM)⁵ 70930¹ NM_001081350.1¹ NP_001074819.1¹ 49653350⁵
chicken (Gallus gallus)	Aves	LOC100858805¹	nucleolar protein 8-like	54.49(n) 42.25(a)		100858805 XM_003641984.1 XP_003642032.1
lizard (Anolis carolinensis)	Reptilia	NOL8⁶	--	41(a)	1 ↔ 1	2(156289787-156311226)
African clawed frog (Xenopus laevis)	Amphibia	Xl.14813²	Xenopus laevis transcribed sequence with weak similarity more	75.62(n)		BI447930.1
zebrafish (Danio rerio)	Actinopterygii	nol8¹	nucleolar protein 8	49.1(n) 37.4(a)		613021 NM_001080202.1 NP_001073671.1
fruit fly (Drosophila melanogaster)	Insecta	CG14230¹	CG14230	41.32(n) 26.33(a)		32984 NM_134505.2 NP_608349.1
worm (Caenorhabditis elegans)	Secernentea	K07F5.14¹	Protein K07F5.14	42.81(n) 26.32(a)		177837 NM_069372.4 NP_501773.1

ENSEMBL Gene Tree for NOL8 (if available)
TreeFam Gene Tree for NOL8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NOL8 gene

4 SIMAP similar genes for NOL8 using alignment to 13 protein entries: NOL8_HUMAN (see all proteins):

DKFZp686P12242 HNRNPD CIRBP RBMX

NOL8 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for NOL8
PGOHUM00000259922

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1152758^1,2	C,A	--	95059180(+)	`AGAGAC/TGGGGT`	3	--	int¹		7		NA WA CSA	13
rs186492768^1,2		--	95059235(+)	`TGATCC/TGCCCG`	3	--	int¹		0	--	--	--	--
rs10992298^1,2	C	--	95059261(+)	`gtactG/Aagatt`	3	--	int¹		2		WA	120
rs189620907^1,2		--	95059289(+)	`CGCCCA/GGCCTA`	3	--	int¹		0	--	--	--	--
rs182346960^1,2		--	95059309(+)	`ATTTCA/TTACAG`	3	--	int¹		0	--	--	--	--
rs186209156^1,2		--	95059358(+)	`GCAGGC/TTGGTT`	3	--	int¹		0	--	--	--	--
rs72750474^1,2	F	--	95059493(+)	`ATTGGT/GGTACA`	3	--	int¹		1		EA	120
rs710162^1,2	C,F,A,H	--	95059790(-)	`TTTTTT/AAATAA`	3	--	ut3¹ nc-transcript-variant		118		NS NA MN EA PA EU CA WA CSA	8289
rs710163^1,2	C,F,A,H	--	95059804(+)	`TTCATA/GTAAAC`	3	--	ut3¹ nc-transcript-variantese³		36		NA EA MN NS WA CSA	3396
rs4298540^1,2	C,F,H	--	95059833(+)	`CATTAG/CTTACT`	3	--	nc-transcript-variantut3¹ ese³		6		NS EA NA	658

HapMap Linkage Disequilibrium report for NOL8 (95059640 - 95087918 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NOL8: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NOL8 for disorders           About GeneDecksing

OMIM gene information: 611534    OMIM disorders: --

3 diseases for NOL8:    About MalaCards

becker muscular dystrophy muscular dystrophy gastric cancer

1 disease from the University of Copenhagen DISEASES database for NOL8:

Becker muscular dystrophy

Human Genome Epidemiology (HuGE) Navigator: NOL8 (1 document)

Export disorders for NOL8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NOL8 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with NOL8)

Utopia: connect your pdf to the dynamic
world of online information

A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. (PubMed id 14660641)^{1, 2, 9} Sekiguchi T....Nishimoto T. (2004)
NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PubMed id 16963496)^{1, 2} Sekiguchi T....Nishimoto T. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer. (PubMed id 15132771)^{1, 2} Jinawath N.... Nakamura Y. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55035	HGNC: 23387	AceView: NOL8	Ensembl:ENSG00000198000	euGenes: HUgn55035
ECgene: NOL8	H-InvDB: NOL8

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NOL8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NOL8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NOL8 gene:
Search GeneIP for patents involving NOL8

GeneCards and IP:
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nucleolar protein 8

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