NOL7 Gene
protein-coding GIFtS: 49
GCID: GC06P013615
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nucleolar protein 7, 27kDa(Previous names: chromosome 6 open reading frame 90, polyglutamine binding...)
(Previous symbols: C6orf90, PQBP3)
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Aliases
for NOL7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleolar Protein 7, 27kDa1 2 | | NOP271 3 | | C6orf901 2 3 | | Nucleolar Protein Of 27 KDa2 3 | | PQBP31 2 | | Chromosome 6 Open Reading Frame 901 | | RARG-11 2 | | Nucleolar Protein 72 | | DJ223E5.21 | | Retinoic Acid Repressible Protein2 | | Polyglutamine Binding Protein 31 2 | | |
Export aliases for NOL7 gene to outside databasesPrevious GC identifer: GC06P013723 |
Summaries
for NOL7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for NOL7
|
Genomic Views
for NOL7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOL7 gene promoter:
Tal-1 POU3F2 Tal-1beta E47 S8 FOXJ2 (long isoform) HFH-1 FOXJ2 Msx-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOL7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOL7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p23 Ensembl cytogenetic band: 6p23 HGNC cytogenetic band: 6p23NOL7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P013615: view genomic region
(about GC identifiers)
Start:
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13,615,559 bp from pter |
End:
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13,632,971 bp from pter |
Size:
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17,413 bases |
Orientation:
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plus strand |
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Proteins
for NOL7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOL7_HUMAN, Q9UMY1 (See
protein sequence)Recommended Name: Nucleolar protein 7 Size: 257 amino acids; 29426 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=CAB43398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=CAI19840.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5T297 Q9Y3U7Alternative splicing: 2 isoforms: Q9UMY1-1 Q9UMY1-2 (Gene prediction based on EST data. No experimental confirmation available)Explore the universe of human proteins at neXtProt for NOL7: NX_Q9UMY1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UMY1
NOL7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057251.2
ENSEMBL proteins: ENSP00000405674 ENSP00000404836
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NOL7 for ontologies About GeneDecksing
NOL7 Antibody Products:
Assay Products for NOL7: |
Protein
Domains /
Families
for NOL7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOL7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UMY1ProtoNet protein and cluster: Q9UMY1 1 Blocks protein family: IPB012579 NUC129
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Function
for NOL7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NOL7 (NM_016167) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOL7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL7 |
|
Pathways & Interactions
for NOL7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOL7
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for NOL7 (Q9UMY12, 3 ENSP000004056744) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for NOL7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NOL7
Search CenterWatch for drugs/clinical trials and news about NOL7
|
Transcripts
for NOL7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOL7 gene: NM_016167.3 Unigene Cluster for NOL7: Nucleolar protein 7, 27kDa Hs.306242 [show with all ESTs]Unigene Representative Sequence: BM9146683 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000451315(uc003naz.3) ENST00000420088 ENST00000474485
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NOL7 (NM_016167) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOL7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL7 |
Additional cDNA sequence: AF172066.3 AL050299.1 BC023517.2 BC062683.1 13 DOTS entries: DT.95195419 DT.100832813 DT.100832837 DT.456189 DT.92447189 DT.212593 DT.121393638 DT.87011368 DT.87016836 DT.121393639 DT.40233025 DT.75134356 DT.87077259 24/308 AceView cDNA sequences (see all 308): BM707905 AA889499 BG942057 BG940694 BU949621 AI379985 BI963211 AI658772 N63209 BG941858 AI246490 BG943802 AI470792 AA904090 BG941492 BU624089 AV713485 AA906988 AI458340 AW966635 BG943712 AI479250 AW517017 AA913359
GeneLoc Exon Structure
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Expression
for NOL7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOL7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCAGCTCC
About this image
See NOL7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOL7
SOURCE GeneReport for Unigene cluster: Hs.306242
UniProtKB/Swiss-Prot: NOL7_HUMAN, Q9UMY1Tissue specificity: Expressed in numerous tissues. Particularly prevalent in the adrenal gland, thyroid gland, heartand skeletal muscle
SABiosciences Custom PCR Arrays for NOL7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOL7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOL7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOL7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOL7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL7 |
Orthologs
for NOL7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for NOL7 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for NOL7 (if available)
TreeFam Gene Tree for NOL7 (if available) |
Paralogs
for NOL7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NOL7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for NOL7 (13615559 - 13632971 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NOL7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOL7 |
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Disorders
/ Diseases
for NOL7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NOL7 for disorders About GeneDecksing
OMIM gene information: 611533
OMIM disorders: --
3  diseases for NOL7: About MalaCardscervical cancer cervicitis thyroiditis
1 disease from the University of Copenhagen DISEASES database for NOL7:Cervical cancer Human Genome Epidemiology (HuGE) Navigator: NOL7 (1 document)
Export disorders for NOL7 gene to outside databases
|
Publications
for NOL7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOL7 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with NOL7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- NOL7 is a nucleolar candidate tumor suppressor gene in cervical cancer that modulates the angiogenic phenotype. (PubMed id 16205646)1, 2, 3 Hasina R.... Lingen M.W. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)1, 2 Andersen J.S.... Lamond A.I. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
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External Searches for NOL7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NOL7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOL7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOL7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOL7 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NOL7 gene:
Search GeneIP for patents involving NOL7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOL7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NOL7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOL7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOL7 | | | OriGene Protein Over-expression Lysate for NOL7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NOL7 | | OriGene 3'-UTR Clone for NOL7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NOL7 | | OriGene Custom Protein Services for NOL7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOL7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOL7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOL7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOL7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOL7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOL7 |
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| | | | Search Tocris compounds for NOL7 |
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 | | | NOL7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL7 |
|  |  |  | | | | ThermoFisher Antibodies for NOL7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL7 |
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