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Aliases for NOL7 Gene

Aliases for NOL7 Gene

  • Nucleolar Protein 7 2 3 5
  • Polyglutamine Binding Protein 3 2 3
  • Nucleolar Protein Of 27 KDa 3 4
  • Nucleolar Protein 7, 27kDa 2 3
  • C6orf90 3 4
  • Chromosome 6 Open Reading Frame 90 2
  • Retinoic Acid Repressible Protein 3
  • DJ223E5.2 3
  • RARG-1 3
  • PQBP3 3
  • NOP27 4

External Ids for NOL7 Gene

Previous HGNC Symbols for NOL7 Gene

  • C6orf90
  • PQBP3

Previous GeneCards Identifiers for NOL7 Gene

  • GC06P013723

Summaries for NOL7 Gene

Entrez Gene Summary for NOL7 Gene

  • The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for NOL7 Gene

NOL7 (Nucleolar Protein 7) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for NOL7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL7 Gene

Genomics for NOL7 Gene

Regulatory Elements for NOL7 Gene

Enhancers for NOL7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G013872 1.4 Ensembl ENCODE 10 +258.2 258245 2.0 PKNOX1 CREB3L1 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ENSG00000272209 RANBP9 NOL7 RNF182 MCUR1 PIR49028
GH06G013613 1.2 ENCODE 0.7 +0.2 214 3.4 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 ENSG00000272209 RANBP9 NOL7 GC06P013623
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOL7 on UCSC Golden Path with GeneCards custom track

Promoters for NOL7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000193485 73 2001 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263

Genomic Location for NOL7 Gene

Chromosome:
6
Start:
13,615,327 bp from pter
End:
13,632,739 bp from pter
Size:
17,413 bases
Orientation:
Plus strand

Genomic View for NOL7 Gene

Genes around NOL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL7 Gene

Proteins for NOL7 Gene

  • Protein details for NOL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMY1-NOL7_HUMAN
    Recommended name:
    Nucleolar protein 7
    Protein Accession:
    Q9UMY1
    Secondary Accessions:
    • Q5T297
    • Q9Y3U7

    Protein attributes for NOL7 Gene

    Size:
    257 amino acids
    Molecular mass:
    29426 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB43398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAI19840.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL7 Gene

Post-translational modifications for NOL7 Gene

  • Ubiquitination at Lys170 and Lys210
  • Modification sites at PhosphoSitePlus

Other Protein References for NOL7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOL7 Gene

Domains & Families for NOL7 Gene

Protein Domains for NOL7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NOL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL7: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOL7 Gene

Function for NOL7 Gene

Gene Ontology (GO) - Molecular Function for NOL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOL7: view
genes like me logo Genes that share phenotypes with NOL7: view

Animal Model Products

CRISPR Products

miRNA for NOL7 Gene

miRTarBase miRNAs that target NOL7

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL7 Gene

Localization for NOL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL7 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL7 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NOL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA --
GO:0005730 nucleolus IDA,IEA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with NOL7: view

Pathways & Interactions for NOL7 Gene

No Data Available

Interacting Proteins for NOL7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000405674%0d%0a9606.ENSP00000260731%0d%0a
Selected Interacting proteins: Q9UMY1-NOL7_HUMAN ENSP00000405674 for NOL7 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for NOL7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOL7 Gene

Drugs & Compounds for NOL7 Gene

No Compound Related Data Available

Transcripts for NOL7 Gene

mRNA/cDNA for NOL7 Gene

Unigene Clusters for NOL7 Gene

Nucleolar protein 7, 27kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL7 Gene

No ASD Table

Relevant External Links for NOL7 Gene

GeneLoc Exon Structure for
NOL7
ECgene alternative splicing isoforms for
NOL7

Expression for NOL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOL7 Gene

This gene is overexpressed in Stomach (22.0), Breast (20.1), and Peripheral blood mononuclear cells (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL7 Gene



Protein tissue co-expression partners for NOL7 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOL7 Gene:

NOL7

SOURCE GeneReport for Unigene cluster for NOL7 Gene:

Hs.306242

mRNA Expression by UniProt/SwissProt for NOL7 Gene:

Q9UMY1-NOL7_HUMAN
Tissue specificity: Expressed in numerous tissues. Particularly prevalent in the adrenal gland, thyroid gland, heart and skeletal muscle.

Evidence on tissue expression from TISSUES for NOL7 Gene

  • Kidney(4.3)
  • Blood(3.2)
  • Nervous system(2.9)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with NOL7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL7 Gene

Orthologs for NOL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOL7 34 35
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia NOL7 34 35
  • 87.89 (n)
dog
(Canis familiaris)
Mammalia NOL7 34 35
  • 87.19 (n)
mouse
(Mus musculus)
Mammalia Nol7 34 16 35
  • 83 (n)
rat
(Rattus norvegicus)
Mammalia Nol7 34
  • 82.8 (n)
oppossum
(Monodelphis domestica)
Mammalia NOL7 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOL7 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOL7 34 35
  • 57.42 (n)
lizard
(Anolis carolinensis)
Reptilia NOL7 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489073 34
  • 56.24 (n)
zebrafish
(Danio rerio)
Actinopterygii nol7 34 35
  • 53.14 (n)
Species where no ortholog for NOL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL7 Gene

ENSEMBL:
Gene Tree for NOL7 (if available)
TreeFam:
Gene Tree for NOL7 (if available)

Paralogs for NOL7 Gene

No data available for Paralogs for NOL7 Gene

Variants for NOL7 Gene

Sequence variations from dbSNP and Humsavar for NOL7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000324763 -- 13,623,646(+) GGCGA(C/T)GCATC intron-variant
rs1000448896 -- 13,629,095(+) CAGCA(A/T)CAATA intron-variant
rs1000480050 -- 13,629,328(+) AGGAA(A/G)TAAAT intron-variant
rs1000655567 -- 13,623,413(+) AAGAA(C/G)AGGAA intron-variant
rs1000702650 -- 13,617,248(+) TTGCC(C/G)CCCCC intron-variant

Variation tolerance for NOL7 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NOL7 Gene

Disorders for NOL7 Gene

Relevant External Links for NOL7

Human Genome Epidemiology (HuGE) Navigator
NOL7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOL7

No disorders were found for NOL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL7 Gene

Publications for NOL7 Gene

  1. NOL7 is a nucleolar candidate tumor suppressor gene in cervical cancer that modulates the angiogenic phenotype. (PMID: 16205646) Hasina R. … Lingen M.W. (Oncogene 2006) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Directed proteomic analysis of the human nucleolus. (PMID: 11790298) Andersen J.S. … Lamond A.I. (Curr. Biol. 2002) 3 4 64

Products for NOL7 Gene

Sources for NOL7 Gene

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