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Aliases for NOL6 Gene

Aliases for NOL6 Gene

  • Nucleolar Protein 6 (RNA-Associated) 2 3
  • NRAP 3 4 6
  • Nucleolar Protein Family 6 (RNA-Associated) 2 3
  • Nucleolar RNA-Associated Protein 3 4
  • Nucleolar Protein 6 3
  • BA311H10.1 3
  • UTP22 3

External Ids for NOL6 Gene

Summaries for NOL6 Gene

Entrez Gene Summary for NOL6 Gene

  • The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOL6 Gene

NOL6 (Nucleolar Protein 6 (RNA-Associated)) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include RNA binding.

Gene Wiki entry for NOL6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL6 Gene

Genomics for NOL6 Gene

Genomic Location for NOL6 Gene

Start:
33,461,353 bp from pter
End:
33,473,943 bp from pter
Size:
12,591 bases
Orientation:
Minus strand

Genomic View for NOL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL6 Gene

Regulatory Elements for NOL6 Gene

Proteins for NOL6 Gene

  • Protein details for NOL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6R4-NOL6_HUMAN
    Recommended name:
    Nucleolar protein 6
    Protein Accession:
    Q9H6R4
    Secondary Accessions:
    • Q5T5M3
    • Q5T5M4
    • Q7L4G6
    • Q8N6I0
    • Q8TEY9
    • Q8TEZ0
    • Q8TEZ1
    • Q9H675

    Protein attributes for NOL6 Gene

    Size:
    1146 amino acids
    Molecular mass:
    127593 Da
    Quaternary structure:
    • Probably associated with rRNA
    SequenceCaution:
    • Sequence=AAH08298.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15189.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15389.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAI13312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13313.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL6 Gene

Proteomics data for NOL6 Gene at MOPED

Post-translational modifications for NOL6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys271

Other Protein References for NOL6 Gene

No data available for DME Specific Peptides for NOL6 Gene

Domains for NOL6 Gene

Protein Domains for NOL6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NOL6_HUMAN
Family:
  • Belongs to the NRAP family.:
    • Q9H6R4
genes like me logo Genes that share domains with NOL6: view

No data available for Gene Families for NOL6 Gene

Function for NOL6 Gene

Gene Ontology (GO) - Molecular Function for NOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOL6: view

Phenotypes for NOL6 Gene

genes like me logo Genes that share phenotypes with NOL6: view

miRNA for NOL6 Gene

miRTarBase miRNAs that target NOL6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NOL6 Gene

Localization for NOL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL6 Gene

Nucleus, nucleolus. Chromosome. Note=Localizes to condensed chromosomes in mitosis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOL6 Gene COMPARTMENTS Subcellular localization image for NOL6 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome ISS 11895476
GO:0005634 nucleus IDA --
GO:0005730 nucleolus ISS --
GO:0005739 mitochondrion IDA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with NOL6: view

Pathways for NOL6 Gene

genes like me logo Genes that share pathways with NOL6: view

Pathways by source for NOL6 Gene

1 KEGG pathway for NOL6 Gene

Gene Ontology (GO) - Biological Process for NOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing ISS --
GO:0006409 tRNA export from nucleus IBA --
genes like me logo Genes that share ontologies with NOL6: view

Transcripts for NOL6 Gene

Unigene Clusters for NOL6 Gene

Nucleolar protein 6 (RNA-associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOL6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - -
SP2: - -
SP3: - - - - - - - - - - - - - - - -
SP4:
SP5:
SP6:
SP7:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c
SP1: -
SP2: -
SP3: - - - - - - - -
SP4: -
SP5:
SP6:
SP7:

Relevant External Links for NOL6 Gene

GeneLoc Exon Structure for
NOL6
ECgene alternative splicing isoforms for
NOL6

Expression for NOL6 Gene

mRNA expression in normal human tissues for NOL6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOL6 Gene

SOURCE GeneReport for Unigene cluster for NOL6 Gene Hs.493709

genes like me logo Genes that share expressions with NOL6: view

Orthologs for NOL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOL6 36
  • 99.51 (n)
  • 99.65 (a)
NOL6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOL6 36
  • 87.75 (n)
  • 89.79 (a)
NOL6 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOL6 36
  • 89.03 (n)
  • 91.36 (a)
NOL6 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nol6 36
  • 85.28 (n)
  • 85.63 (a)
Nol6 16
Nol6 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOL6 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOL6 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nol6 36
  • 85.93 (n)
  • 87.33 (a)
chicken
(Gallus gallus)
Aves NOL6 36
  • 63.62 (n)
  • 62.25 (a)
NOL6 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
OneToMany
-- 37
  • 61 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.3810 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nol6 36
  • 61.54 (n)
  • 59.36 (a)
zebrafish
(Danio rerio)
Actinopterygii nol6 36
  • 57.28 (n)
  • 53.83 (a)
nol6 37
  • 52 (a)
OneToOne
wufi43b02 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003992 36
  • 48.38 (n)
  • 37.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mat89Ba 36
  • 45.78 (n)
  • 36.67 (a)
Mat89Ba 37
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nol-6 37
  • 25 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR029W 36
  • 43.2 (n)
  • 28.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP22 36
  • 40.55 (n)
  • 30.35 (a)
UTP22 37
  • 22 (a)
OneToOne
UTP22 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14806g 36
  • 40.38 (n)
  • 28.45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G63810 36
  • 43.69 (n)
  • 33.83 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09437 36
  • 43.14 (n)
  • 30.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC776.08c 36
  • 39.12 (n)
  • 27.62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToOne
Species with no ortholog for NOL6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOL6 Gene

ENSEMBL:
Gene Tree for NOL6 (if available)
TreeFam:
Gene Tree for NOL6 (if available)

Paralogs for NOL6 Gene

No data available for Paralogs for NOL6 Gene

Variants for NOL6 Gene

Sequence variations from dbSNP and Humsavar for NOL6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs507758 -- 33,466,861(-) TGCGG(A/G)GAGAG intron-variant
rs560833 -- 33,465,653(-) TCTCC(A/G)GGGGC intron-variant
rs678859 -- 33,461,569(-) TGGCT(C/T)ATGCT utr-variant-3-prime
rs1059975 -- 33,462,333(-) CCTTT(C/T)TTAGT utr-variant-3-prime
rs1059978 -- 33,462,185(-) CCCTT(C/T)TGAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NOL6 Gene

Variant ID Type Subtype PubMed ID
nsv516500 CNV Loss 19592680
nsv518168 CNV Loss 19592680
nsv527128 CNV Loss 19592680

Relevant External Links for NOL6 Gene

HapMap Linkage Disequilibrium report
NOL6

Disorders for NOL6 Gene

Relevant External Links for NOL6

Genetic Association Database (GAD)
NOL6
genes like me logo Genes that share disorders with NOL6: view

No data available for UniProtKB/Swiss-Prot for NOL6 Gene

Publications for NOL6 Gene

  1. Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans. (PMID: 11895476) Utama B. … Mattick J.S. (Genes Cells 2002) 2 3 4 23
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NOL6 Gene

Sources for NOL6 Gene

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