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Aliases for NOL6 Gene

Aliases for NOL6 Gene

  • Nucleolar Protein 6 2 3 5
  • Nucleolar Protein Family 6 (RNA-Associated) 2 3
  • Nucleolar Protein 6 (RNA-Associated) 2 3
  • Nucleolar RNA-Associated Protein 3 4
  • NRAP 3 4
  • BA311H10.1 3
  • UTP22 3

External Ids for NOL6 Gene

Previous GeneCards Identifiers for NOL6 Gene

  • GC09M033630

Summaries for NOL6 Gene

Entrez Gene Summary for NOL6 Gene

  • The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOL6 Gene

NOL6 (Nucleolar Protein 6) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

Gene Wiki entry for NOL6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL6 Gene

Genomics for NOL6 Gene

Regulatory Elements for NOL6 Gene

Enhancers for NOL6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOL6 on UCSC Golden Path with GeneCards custom track

Promoters for NOL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOL6 Gene

33,461,353 bp from pter
33,473,943 bp from pter
12,591 bases
Minus strand

Genomic View for NOL6 Gene

Genes around NOL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL6 Gene

Proteins for NOL6 Gene

  • Protein details for NOL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5T5M3
    • Q5T5M4
    • Q7L4G6
    • Q8N6I0
    • Q8TEY9
    • Q8TEZ0
    • Q8TEZ1
    • Q9H675

    Protein attributes for NOL6 Gene

    1146 amino acids
    Molecular mass:
    127593 Da
    Quaternary structure:
    • Probably associated with rRNA.
    • Sequence=AAH08298.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15189.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15389.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAI13312.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13313.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL6 Gene


neXtProt entry for NOL6 Gene

Proteomics data for NOL6 Gene at MOPED

Post-translational modifications for NOL6 Gene

  • Ubiquitination at Lys 271
  • Modification sites at PhosphoSitePlus

Other Protein References for NOL6 Gene

No data available for DME Specific Peptides for NOL6 Gene

Domains & Families for NOL6 Gene

Protein Domains for NOL6 Gene


Suggested Antigen Peptide Sequences for NOL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NRAP family.
  • Belongs to the NRAP family.
genes like me logo Genes that share domains with NOL6: view

No data available for Gene Families for NOL6 Gene

Function for NOL6 Gene

genes like me logo Genes that share phenotypes with NOL6: view

Animal Model Products

miRNA for NOL6 Gene

miRTarBase miRNAs that target NOL6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL6 Gene

Localization for NOL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL6 Gene

Nucleus, nucleolus. Chromosome. Note=Localizes to condensed chromosomes in mitosis. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for NOL6 Gene COMPARTMENTS Subcellular localization image for NOL6 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IEA,ISS 11895476
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with NOL6: view

Pathways & Interactions for NOL6 Gene

genes like me logo Genes that share pathways with NOL6: view

Pathways by source for NOL6 Gene

Gene Ontology (GO) - Biological Process for NOL6 Gene


No data available for SIGNOR curated interactions for NOL6 Gene

Drugs & Compounds for NOL6 Gene

No Compound Related Data Available

Transcripts for NOL6 Gene

Unigene Clusters for NOL6 Gene

Nucleolar protein 6 (RNA-associated):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOL6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - -
SP2: - -
SP3: - - - - - - - - - - - - - - - -

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c
SP1: -
SP2: -
SP3: - - - - - - - -
SP4: -

Relevant External Links for NOL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOL6 Gene

mRNA expression in normal human tissues for NOL6 Gene

Protein differential expression in normal tissues from HIPED for NOL6 Gene

This gene is overexpressed in Nasal epithelium (39.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOL6 Gene

SOURCE GeneReport for Unigene cluster for NOL6 Gene Hs.493709

genes like me logo Genes that share expression patterns with NOL6: view

Protein tissue co-expression partners for NOL6 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOL6 Gene

Orthologs for NOL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOL6 35
  • 87.75 (n)
  • 89.79 (a)
NOL6 36
  • 89 (a)
(Canis familiaris)
Mammalia NOL6 35
  • 89.03 (n)
  • 91.36 (a)
NOL6 36
  • 91 (a)
(Mus musculus)
Mammalia Nol6 35
  • 85.28 (n)
  • 85.63 (a)
Nol6 16
Nol6 36
  • 84 (a)
(Pan troglodytes)
Mammalia NOL6 35
  • 99.51 (n)
  • 99.65 (a)
NOL6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nol6 35
  • 85.93 (n)
  • 87.33 (a)
(Monodelphis domestica)
Mammalia NOL6 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia NOL6 36
  • 69 (a)
(Gallus gallus)
Aves NOL6 35
  • 63.62 (n)
  • 62.25 (a)
NOL6 36
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
-- 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nol6 35
  • 61.54 (n)
  • 59.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3810 35
(Danio rerio)
Actinopterygii nol6 35
  • 57.28 (n)
  • 53.83 (a)
wufi43b02 35
nol6 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003992 35
  • 48.38 (n)
  • 37.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mat89Ba 35
  • 45.78 (n)
  • 36.67 (a)
Mat89Ba 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea nol-6 36
  • 25 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR029W 35
  • 43.2 (n)
  • 28.51 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14806g 35
  • 40.38 (n)
  • 28.45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP22 35
  • 40.55 (n)
  • 30.35 (a)
UTP22 36
  • 22 (a)
UTP22 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G63810 35
  • 43.69 (n)
  • 33.83 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09437 35
  • 43.14 (n)
  • 30.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC776.08c 35
  • 39.12 (n)
  • 27.62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for NOL6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOL6 Gene

Gene Tree for NOL6 (if available)
Gene Tree for NOL6 (if available)

Paralogs for NOL6 Gene

No data available for Paralogs for NOL6 Gene

Variants for NOL6 Gene

Sequence variations from dbSNP and Humsavar for NOL6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10971523 - 33,472,313(+) CACTG(A/G)CTGCA reference, missense
rs35135082 - 33,466,350(-) TGCCC(C/G/T)GGCTC intron-variant, reference, missense
rs678859 -- 33,461,569(-) TGGCT(C/T)ATGCT utr-variant-3-prime
rs1059975 -- 33,462,333(-) CCTTT(C/T)TTAGT utr-variant-3-prime
rs1059978 -- 33,462,185(-) CCCTT(C/T)TGAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NOL6 Gene

Variant ID Type Subtype PubMed ID
nsv516500 CNV Loss 19592680
nsv518168 CNV Loss 19592680
nsv527128 CNV Loss 19592680

Variation tolerance for NOL6 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NOL6 Gene

Disorders for NOL6 Gene

Relevant External Links for NOL6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL6 Gene

Publications for NOL6 Gene

  1. Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans. (PMID: 11895476) Utama B. … Mattick J.S. (Genes Cells 2002) 2 3 4 23 67
  2. The small-subunit processome is a ribosome assembly intermediate. (PMID: 15590835) Bernstein K.A. … Baserga S.J. (Eukaryotic Cell 2004) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for NOL6 Gene

Sources for NOL6 Gene