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Aliases for NOL4L Gene

Aliases for NOL4L Gene

  • Nucleolar Protein 4 Like 2 3 5
  • C20orf112 3 4
  • C20orf113 3 4
  • Chromosome 20 Open Reading Frame 113 2
  • Chromosome 20 Open Reading Frame 112 2
  • Hypothetical Protein LOC140688 2
  • Nucleolar Protein 4-Like 3

External Ids for NOL4L Gene

Previous HGNC Symbols for NOL4L Gene

  • C20orf113
  • C20orf112

Summaries for NOL4L Gene

GeneCards Summary for NOL4L Gene

NOL4L (Nucleolar Protein 4 Like) is a Protein Coding gene. An important paralog of this gene is NOL4.

Additional gene information for NOL4L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL4L Gene

Genomics for NOL4L Gene

Regulatory Elements for NOL4L Gene

Enhancers for NOL4L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H032521 2.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 13.2 +59.4 59394 8 HDGF FOXA2 MLX ARID4B DMAP1 ZNF2 SLC30A9 ZNF143 RUNX3 SP5 ENSG00000233293 NOL4L COMMD7 HCK MAPRE1 C20orf203 NOL4L-DT ENSG00000260257 PLAGL2 LOC105372592
GH20H032461 1.6 Ensembl ENCODE dbSUPER 16.7 +110.7 110744 24 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 NOL4L ENSG00000236772 ENSG00000233293 C20orf203 POFUT1 KIF3B EFCAB8 GC20M032477
GH20H032626 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -43.1 -43098 2 TBP PKNOX1 NFIB ZNF121 ZNF143 RCOR1 RUNX3 CREM IKZF2 SMARCA5 NOL4L ENSG00000233293 COMMD7 BAK1P1 BPIFB6 C20orf203
GH20H032507 1.5 Ensembl ENCODE dbSUPER 11.8 +75.0 75011 5 PKNOX1 FOXA2 MLX ARNT ARID4B TCF12 SLC30A9 ZNF766 GATA2 ZNF143 ENSG00000233293 NOL4L ENSG00000236772 NOL4L-DT TSPY26P GC20P032510 LOC105372592
GH20H032631 0.9 dbSUPER 16.4 -48.1 -48099 3 TBP TBL1XR1 NFRKB TCF12 ZNF766 ZSCAN5C ATF7 SMARCA5 SMAD5 CEBPB TM9SF4 ASXL1 POFUT1 CDK5RAP1 NOL4L ENSG00000233293 PLAGL2 C20orf203 COMMD7 DNMT3B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOL4L on UCSC Golden Path with GeneCards custom track

Promoters for NOL4L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136159 774 2601 RB1 FUS INSM2 ZNF76 KLF17 RARA EGR1 EGR2 ZEB2 ZNF398

Genomic Location for NOL4L Gene

Chromosome:
20
Start:
32,443,059 bp from pter
End:
32,585,074 bp from pter
Size:
142,016 bases
Orientation:
Minus strand

Genomic View for NOL4L Gene

Genes around NOL4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL4L Gene

Proteins for NOL4L Gene

  • Protein details for NOL4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MY1-NOL4L_HUMAN
    Recommended name:
    Nucleolar protein 4-like
    Protein Accession:
    Q96MY1
    Secondary Accessions:
    • Q5JYB7
    • Q6P0Y4
    • Q9BR34
    • Q9NQF6

    Protein attributes for NOL4L Gene

    Size:
    436 amino acids
    Molecular mass:
    47215 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NOL4L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL4L Gene

Post-translational modifications for NOL4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOL4L Gene

Domains & Families for NOL4L Gene

Gene Families for NOL4L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOL4L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOL4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL4L: view

No data available for UniProtKB/Swiss-Prot for NOL4L Gene

Function for NOL4L Gene

Phenotypes From GWAS Catalog for NOL4L Gene

Gene Ontology (GO) - Molecular Function for NOL4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NOL4L: view
genes like me logo Genes that share phenotypes with NOL4L: view

Animal Model Products

CRISPR Products

miRNA for NOL4L Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL4L Gene

Localization for NOL4L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL4L gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOL4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NOL4L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NOL4L Gene

Pathways & Interactions for NOL4L Gene

SuperPathways for NOL4L Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL4L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOL4L Gene

Drugs & Compounds for NOL4L Gene

No Compound Related Data Available

Transcripts for NOL4L Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL4L Gene

No ASD Table

Relevant External Links for NOL4L Gene

GeneLoc Exon Structure for
NOL4L
ECgene alternative splicing isoforms for
NOL4L

Expression for NOL4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOL4L Gene

This gene is overexpressed in Fetal Brain (40.8), Retina (21.1), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL4L Gene



Protein tissue co-expression partners for NOL4L Gene

NURSA nuclear receptor signaling pathways regulating expression of NOL4L Gene:

NOL4L

Evidence on tissue expression from TISSUES for NOL4L Gene

  • Nervous system(4.6)
  • Skin(4.2)
  • Gall bladder(2.1)
  • Intestine(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with NOL4L: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL4L Gene

Orthologs for NOL4L Gene

This gene was present in the common ancestor of animals.

Orthologs for NOL4L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C20H20orf112 33
  • 99.33 (n)
C20orf112 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C13H20orf112 33
  • 92.22 (n)
C20orf112 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 8430427H17Rik 33 34
  • 91.02 (n)
Nol4l 16
dog
(Canis familiaris)
Mammalia C20orf112 34
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C20orf112 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 23 (a)
ManyToMany
chicken
(Gallus gallus)
Aves C20H20ORF112 33
  • 85.14 (n)
C20orf112 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C20orf112 34
  • 13 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c20orf112 33
  • 69.97 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-80n10.2 33
  • 65.74 (n)
C23H20orf112 (1 of 2) 34
  • 62 (a)
OneToMany
C8H20orf112 (2 of 2) 34
  • 39 (a)
OneToMany
wufa08e04 33
fruit fly
(Drosophila melanogaster)
Insecta CG16879 34
  • 8 (a)
OneToOne
Species where no ortholog for NOL4L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL4L Gene

ENSEMBL:
Gene Tree for NOL4L (if available)
TreeFam:
Gene Tree for NOL4L (if available)

Paralogs for NOL4L Gene

Paralogs for NOL4L Gene

genes like me logo Genes that share paralogs with NOL4L: view

Variants for NOL4L Gene

Sequence variations from dbSNP and Humsavar for NOL4L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000049556 -- 32,446,694(+) GTCTG(A/G)ACTTA utr-variant-3-prime
rs1000056030 -- 32,490,268(+) AATAA(C/T)TGAAA intron-variant
rs1000061828 -- 32,584,095(+) CTCCC(C/T)CCCCC intron-variant
rs1000072307 -- 32,530,497(+) GATCG(C/G)GCCAC intron-variant
rs1000078981 -- 32,500,292(+) AGACC(C/T)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOL4L Gene

Variant ID Type Subtype PubMed ID
dgv7557n54 CNV gain 21841781
esv2044093 CNV deletion 18987734
esv22458 CNV loss 19812545
esv2503295 CNV loss 19546169
esv2642082 CNV insertion 19546169
esv2663457 CNV deletion 23128226
esv3335108 CNV duplication 20981092
esv3645665 CNV loss 21293372
esv3645667 CNV loss 21293372
esv5797 CNV gain 19470904
nsv1056411 CNV loss 25217958
nsv1072530 CNV deletion 25765185
nsv1072531 CNV deletion 25765185
nsv1072532 CNV deletion 25765185
nsv1112787 CNV deletion 24896259
nsv1143981 CNV deletion 24896259
nsv178820 CNV deletion 16902084
nsv509765 CNV insertion 20534489
nsv509766 CNV insertion 20534489
nsv521347 CNV gain 19592680
nsv523511 CNV loss 19592680
nsv585913 CNV loss 21841781
nsv585914 CNV gain+loss 21841781
nsv585917 CNV loss 21841781
nsv819614 CNV gain 19587683
nsv833955 CNV loss 17160897
nsv954022 CNV deletion 24416366

Variation tolerance for NOL4L Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL4L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL4L Gene

Disorders for NOL4L Gene

Relevant External Links for NOL4L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOL4L

No disorders were found for NOL4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL4L Gene

Publications for NOL4L Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 2 3 4 60
  2. CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia. (PMID: 20520637) Guastadisegni MC … Storlazzi CT (Leukemia 2010) 2 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil SA … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for NOL4L Gene

Sources for NOL4L Gene

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