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Aliases for NOL4L Gene

Aliases for NOL4L Gene

  • Nucleolar Protein 4 Like 2 3
  • Nucleolar Protein 4-Like 3 5
  • C20orf112 3 4
  • C20orf113 3 4
  • Chromosome 20 Open Reading Frame 113 2
  • Chromosome 20 Open Reading Frame 112 2
  • Hypothetical Protein LOC140688 2
  • DJ1184F4.2 3
  • DJ1184F4.4 3

External Ids for NOL4L Gene

Previous HGNC Symbols for NOL4L Gene

  • C20orf113
  • C20orf112

Summaries for NOL4L Gene

GeneCards Summary for NOL4L Gene

NOL4L (Nucleolar Protein 4 Like) is a Protein Coding gene. An important paralog of this gene is ENSG00000283233.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL4L Gene

Genomics for NOL4L Gene

Regulatory Elements for NOL4L Gene

Enhancers for NOL4L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NOL4L on UCSC Golden Path with GeneCards custom track

Promoters for NOL4L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOL4L on UCSC Golden Path with GeneCards custom track

Genomic Location for NOL4L Gene

Chromosome:
20
Start:
32,443,059 bp from pter
End:
32,585,074 bp from pter
Size:
142,016 bases
Orientation:
Minus strand

Genomic View for NOL4L Gene

Genes around NOL4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL4L Gene

Proteins for NOL4L Gene

  • Protein details for NOL4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MY1-NOL4L_HUMAN
    Recommended name:
    Nucleolar protein 4-like
    Protein Accession:
    Q96MY1
    Secondary Accessions:
    • Q5JYB7
    • Q6P0Y4
    • Q9BR34
    • Q9NQF6

    Protein attributes for NOL4L Gene

    Size:
    436 amino acids
    Molecular mass:
    47215 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NOL4L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL4L Gene

Post-translational modifications for NOL4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOL4L Gene

Domains & Families for NOL4L Gene

Protein Domains for NOL4L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOL4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL4L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOL4L Gene

Function for NOL4L Gene

Gene Ontology (GO) - Molecular Function for NOL4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NOL4L: view
genes like me logo Genes that share phenotypes with NOL4L: view

Animal Model Products

miRNA for NOL4L Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL4L Gene

Localization for NOL4L Gene

Gene Ontology (GO) - Cellular Components for NOL4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NOL4L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NOL4L Gene

Pathways & Interactions for NOL4L Gene

SuperPathways for NOL4L Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL4L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOL4L Gene

Drugs & Compounds for NOL4L Gene

No Compound Related Data Available

Transcripts for NOL4L Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL4L Gene

No ASD Table

Relevant External Links for NOL4L Gene

GeneLoc Exon Structure for
NOL4L
ECgene alternative splicing isoforms for
NOL4L

Expression for NOL4L Gene

mRNA expression in normal human tissues for NOL4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOL4L Gene

This gene is overexpressed in Fetal Brain (40.8), Retina (21.1), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL4L Gene



Protein tissue co-expression partners for NOL4L Gene

NURSA nuclear receptor signaling pathways regulating expression of NOL4L Gene:

NOL4L
genes like me logo Genes that share expression patterns with NOL4L: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOL4L Gene

Orthologs for NOL4L Gene

This gene was present in the common ancestor of animals.

Orthologs for NOL4L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C13H20orf112 34
  • 92.22 (n)
  • 96.69 (a)
C20orf112 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 8430427H17Rik 34
  • 91.02 (n)
  • 96.17 (a)
Nol4l 16
8430427H17Rik 35
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20orf112 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 23 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia C20orf112 35
  • 99 (a)
OneToOne
C20H20orf112 34
  • 99.33 (n)
  • 99.27 (a)
oppossum
(Monodelphis domestica)
Mammalia C20orf112 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20orf112 35
  • 60 (a)
OneToOne
C20H20ORF112 34
  • 85.14 (n)
  • 91.04 (a)
lizard
(Anolis carolinensis)
Reptilia C20orf112 35
  • 13 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c20orf112 34
  • 69.97 (n)
  • 71.29 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-80n10.2 34
  • 65.74 (n)
  • 65.18 (a)
wufa08e04 34
C8H20orf112 (2 of 2) 35
  • 39 (a)
OneToMany
C23H20orf112 (1 of 2) 35
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG16879 35
  • 8 (a)
OneToOne
Species where no ortholog for NOL4L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL4L Gene

ENSEMBL:
Gene Tree for NOL4L (if available)
TreeFam:
Gene Tree for NOL4L (if available)

Paralogs for NOL4L Gene

Paralogs for NOL4L Gene

genes like me logo Genes that share paralogs with NOL4L: view

Variants for NOL4L Gene

Sequence variations from dbSNP and Humsavar for NOL4L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs11725 -- 32,444,199(+) GGTAG(A/T)TACAG utr-variant-3-prime
rs176814 -- 32,498,767(+) TCAAT(A/T)AAAAA intron-variant
rs875519 -- 32,503,432(+) GAAGC(C/T)CGGGA intron-variant
rs879829 -- 32,526,676(-) CATGC(C/T)GACTT intron-variant
rs881432 -- 32,544,343(-) CCCCA(A/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOL4L Gene

Variant ID Type Subtype PubMed ID
dgv7557n54 CNV gain 21841781
esv2044093 CNV deletion 18987734
esv22458 CNV loss 19812545
esv2503295 CNV loss 19546169
esv2642082 CNV insertion 19546169
esv2663457 CNV deletion 23128226
esv3335108 CNV duplication 20981092
esv3645665 CNV loss 21293372
esv3645667 CNV loss 21293372
esv5797 CNV gain 19470904
nsv1056411 CNV loss 25217958
nsv1072530 CNV deletion 25765185
nsv1072531 CNV deletion 25765185
nsv1072532 CNV deletion 25765185
nsv1112787 CNV deletion 24896259
nsv1143981 CNV deletion 24896259
nsv178820 CNV deletion 16902084
nsv509765 CNV insertion 20534489
nsv509766 CNV insertion 20534489
nsv521347 CNV gain 19592680
nsv523511 CNV loss 19592680
nsv585913 CNV loss 21841781
nsv585914 CNV gain+loss 21841781
nsv585917 CNV loss 21841781
nsv819614 CNV gain 19587683
nsv833955 CNV loss 17160897
nsv954022 CNV deletion 24416366

Variation tolerance for NOL4L Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL4L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL4L Gene

Disorders for NOL4L Gene

Relevant External Links for NOL4L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOL4L

No disorders were found for NOL4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL4L Gene

Publications for NOL4L Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 2 3 4 65
  2. CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia. (PMID: 20520637) Guastadisegni M.C. … Storlazzi C.T. (Leukemia 2010) 2 3 65
  3. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for NOL4L Gene

Sources for NOL4L Gene

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