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Aliases for NOL4 Gene

Aliases for NOL4 Gene

  • Nucleolar Protein 4 2 3 5
  • Cancer/Testis Antigen 125 2 3
  • NOLP 3 4
  • Nucleolar Localized Protein 3
  • Nucleolar-Localized Protein 4
  • HRIHFB2255 3
  • CT125 3

External Ids for NOL4 Gene

Previous GeneCards Identifiers for NOL4 Gene

  • GC18M031465
  • GC18M031251
  • GC18M029684
  • GC18M029686
  • GC18M028290

Summaries for NOL4 Gene

GeneCards Summary for NOL4 Gene

NOL4 (Nucleolar Protein 4) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is NOL4L.

Gene Wiki entry for NOL4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL4 Gene

Genomics for NOL4 Gene

Regulatory Elements for NOL4 Gene

Enhancers for NOL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G034657 1.8 FANTOM5 Ensembl ENCODE dbSUPER 3.9 -435.2 -435235 4.8 PKNOX1 SIN3A YY1 ETS1 GATA2 ZNF143 FOS ZHX2 TSHZ1 MAFF DTNA NOL4 MAPRE2 RPL10AP13 ENSG00000268873
GH18G034706 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.1 -484.4 -484399 4.9 PKNOX1 FEZF1 FOS ZNF263 MBD2 STAT3 WT1 PRDM4 SP7 CTCF DTNA MAPRE2 NOL4 ENSG00000268873 RPL10AP13
GH18G033880 0.3 FANTOM5 2.4 +344.3 344276 0.4 NOL4 GC18M034002 ENSG00000199204 GC18P033757
GH18G034224 0.9 ENCODE 0.7 -0.1 -130 0.3 RAD21 GLIS2 ZNF366 ZNF143 PCBP1 CREM GATAD2B ZNF398 SMARCA4 GLIS1 ENSG00000278052 NOL4
GH18G034225 0.9 ENCODE 0.7 +0.3 311 0.6 PKNOX1 ZSCAN4 GLIS2 ZNF366 PCBP1 CREM GATAD2B ZNF398 REST ZNF843 NOL4 ENSG00000267746
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOL4 on UCSC Golden Path with GeneCards custom track

Promoters for NOL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000102102 52 201 PKNOX1 ZSCAN4 RAD21 GLIS2 ZNF366 PCBP1 CREM GATAD2B ZNF398 REST

Genomic Location for NOL4 Gene

Chromosome:
18
Start:
33,851,100 bp from pter
End:
34,224,952 bp from pter
Size:
373,853 bases
Orientation:
Minus strand

Genomic View for NOL4 Gene

Genes around NOL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL4 Gene

Proteins for NOL4 Gene

  • Protein details for NOL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94818-NOL4_HUMAN
    Recommended name:
    Nucleolar protein 4
    Protein Accession:
    O94818
    Secondary Accessions:
    • B4DSQ0
    • B7Z3Z7
    • F5H1E3
    • Q6IBS2
    • Q9BWF1

    Protein attributes for NOL4 Gene

    Size:
    638 amino acids
    Molecular mass:
    71357 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH00313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA34576.1; Type=Erroneous termination; Positions=38; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=BAA34576.1; Type=Frameshift; Positions=82; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL4 Gene

Post-translational modifications for NOL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOL4 Gene

Domains & Families for NOL4 Gene

Protein Domains for NOL4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOL4 Gene

Function for NOL4 Gene

Molecular function for NOL4 Gene

GENATLAS Biochemistry:
nucleolar protein 4

Gene Ontology (GO) - Molecular Function for NOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9813152
genes like me logo Genes that share ontologies with NOL4: view
genes like me logo Genes that share phenotypes with NOL4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL4 Gene

Localization for NOL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL4 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with NOL4: view

Pathways & Interactions for NOL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOL4 Gene

Drugs & Compounds for NOL4 Gene

No Compound Related Data Available

Transcripts for NOL4 Gene

Unigene Clusters for NOL4 Gene

Nucleolar protein 4:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: -
SP3: - - - -

Relevant External Links for NOL4 Gene

GeneLoc Exon Structure for
NOL4
ECgene alternative splicing isoforms for
NOL4

Expression for NOL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Cerebellar Hemisphere (x4.4), Brain - Cortex (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for NOL4 Gene

This gene is overexpressed in Frontal cortex (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOL4 Gene



Protein tissue co-expression partners for NOL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOL4 Gene:

NOL4

SOURCE GeneReport for Unigene cluster for NOL4 Gene:

Hs.514795

mRNA Expression by UniProt/SwissProt for NOL4 Gene:

O94818-NOL4_HUMAN
Tissue specificity: Expressed predominantly in fetal brain, adult brain and testis.

Evidence on tissue expression from TISSUES for NOL4 Gene

  • Nervous system(4.8)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with NOL4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL4 Gene

Orthologs for NOL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOL4 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia NOL4 34 35
  • 94.88 (n)
cow
(Bos Taurus)
Mammalia NOL4 34 35
  • 93.36 (n)
oppossum
(Monodelphis domestica)
Mammalia NOL4 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nol4 34 16 35
  • 89.68 (n)
rat
(Rattus norvegicus)
Mammalia Nol4 34
  • 84.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NOL4 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOL4 34 35
  • 88.3 (n)
lizard
(Anolis carolinensis)
Reptilia NOL4 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nol4 34
  • 80.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS01523.1 36
  • 75 (a)
CG17341 35
  • 24 (a)
OneToOne
Species where no ortholog for NOL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NOL4 Gene

ENSEMBL:
Gene Tree for NOL4 (if available)
TreeFam:
Gene Tree for NOL4 (if available)

Paralogs for NOL4 Gene

Paralogs for NOL4 Gene

(2) SIMAP similar genes for NOL4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NOL4: view

Variants for NOL4 Gene

Sequence variations from dbSNP and Humsavar for NOL4 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000009923 -- 34,013,169(+) TAGTA(A/T)CCCAA intron-variant
rs1000013499 -- 34,006,788(+) GGTGG(A/G)ATGAT intron-variant
rs1000016982 -- 34,106,217(+) TATAA(C/T)TGAGT intron-variant
rs1000024258 -- 34,064,583(+) ATTCC(A/T)AGTTA intron-variant
rs1000032671 -- 34,099,009(+) TTAAT(A/G)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOL4 Gene

Variant ID Type Subtype PubMed ID
dgv58n6 CNV deletion 16902084
esv1010069 CNV deletion 20482838
esv1694854 CNV deletion 17803354
esv2019786 CNV deletion 18987734
esv2663858 CNV deletion 23128226
esv2668525 CNV deletion 23128226
esv2670669 CNV deletion 23128226
esv2716952 CNV deletion 23290073
esv3222 CNV loss 18987735
esv3303199 CNV mobile element insertion 20981092
esv3348179 CNV insertion 20981092
esv3555212 CNV deletion 23714750
esv3642176 CNV loss 21293372
esv3642180 CNV loss 21293372
esv3642181 CNV loss 21293372
esv3642182 CNV loss 21293372
esv3642183 CNV loss 21293372
nsv1071450 CNV deletion 25765185
nsv1134709 CNV deletion 24896259
nsv1150892 CNV deletion 26484159
nsv132109 CNV insertion 16902084
nsv458048 CNV loss 19166990
nsv458049 CNV loss 19166990
nsv470415 CNV gain 18288195
nsv519676 CNV gain 19592680
nsv576643 CNV gain 21841781
nsv576646 CNV loss 21841781
nsv576647 CNV loss 21841781
nsv576648 CNV loss 21841781
nsv576649 CNV loss 21841781
nsv954942 CNV deletion 24416366

Variation tolerance for NOL4 Gene

Residual Variation Intolerance Score: 6.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL4 Gene

Disorders for NOL4 Gene

Relevant External Links for NOL4

Genetic Association Database (GAD)
NOL4
Human Genome Epidemiology (HuGE) Navigator
NOL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOL4

No disorders were found for NOL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL4 Gene

Publications for NOL4 Gene

  1. NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization. (PMID: 9813152) Ueki N. … Muramatsu M.-A. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. A genomewide association study of citalopram response in major depressive disorder. (PMID: 19846067) Garriock H.A. … Hamilton S.P. (Biol. Psychiatry 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NOL4 Gene

Sources for NOL4 Gene

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