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Aliases for NOL4 Gene

Aliases for NOL4 Gene

  • Nucleolar Protein 4 2 3 5
  • Cancer/Testis Antigen 125 2 3
  • NOLP 3 4
  • Nucleolar Localized Protein 3
  • Nucleolar-Localized Protein 4
  • HRIHFB2255 3
  • CT125 3

External Ids for NOL4 Gene

Previous GeneCards Identifiers for NOL4 Gene

  • GC18M031465
  • GC18M031251
  • GC18M029684
  • GC18M029686
  • GC18M028290

Summaries for NOL4 Gene

GeneCards Summary for NOL4 Gene

NOL4 (Nucleolar Protein 4) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is ENSG00000283233.

Gene Wiki entry for NOL4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL4 Gene

Genomics for NOL4 Gene

Regulatory Elements for NOL4 Gene

Enhancers for NOL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F034657 1.5 FANTOM5 Ensembl ENCODE 3.9 -435.2 -435235 4.8 PKNOX1 SIN3A ETS1 YY1 ZNF143 FOS TSHZ1 MAFF RFX3 PBX2 DTNA NOL4 MAPRE2 RPL10AP13 LOC105372062
GH18F034706 1.3 FANTOM5 ENCODE 1.2 -484.4 -484399 4.9 PKNOX1 BMI1 FEZF1 RAD21 RFX5 ZNF366 RCOR1 FOS EGR2 ZNF263 DTNA MAPRE2 NOL4 LOC105372062 RPL10AP13
GH18F034225 0.9 ENCODE 0.8 +0.3 311 0.6 PKNOX1 GLIS2 ZNF366 CREM REST ZNF843 ZNF610 GLIS1 IRF1 ZBTB26 ENSG00000267746 NOL4
GH18F033880 0.3 FANTOM5 2.4 +344.3 344276 0.4 NOL4 ENSG00000199204 GC18M034002 GC18P033757
GH18F034224 0.8 ENCODE 0.8 -0.1 -130 0.3 CTCF SUZ12 MAX RAD21 GLIS2 ZBTB48 ZNF366 PATZ1 ZNF143 PRDM10 ENSG00000278052 NOL4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOL4 on UCSC Golden Path with GeneCards custom track

Promoters for NOL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001812465 51 1000 PKNOX1 RAD21 GLIS2 ZNF366 CREM REST ZNF843 ZNF610 SMARCA4 GLIS1

Genomic Location for NOL4 Gene

Chromosome:
18
Start:
33,851,100 bp from pter
End:
34,224,952 bp from pter
Size:
373,853 bases
Orientation:
Minus strand

Genomic View for NOL4 Gene

Genes around NOL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL4 Gene

Proteins for NOL4 Gene

  • Protein details for NOL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94818-NOL4_HUMAN
    Recommended name:
    Nucleolar protein 4
    Protein Accession:
    O94818
    Secondary Accessions:
    • B4DSQ0
    • B7Z3Z7
    • F5H1E3
    • Q6IBS2
    • Q9BWF1

    Protein attributes for NOL4 Gene

    Size:
    638 amino acids
    Molecular mass:
    71357 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH00313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA34576.1; Type=Erroneous termination; Positions=38; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=BAA34576.1; Type=Frameshift; Positions=82; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL4 Gene

Post-translational modifications for NOL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NOL4 Gene

Domains & Families for NOL4 Gene

Protein Domains for NOL4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOL4 Gene

Function for NOL4 Gene

Molecular function for NOL4 Gene

GENATLAS Biochemistry:
nucleolar protein 4

Gene Ontology (GO) - Molecular Function for NOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9813152
genes like me logo Genes that share ontologies with NOL4: view
genes like me logo Genes that share phenotypes with NOL4: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL4 Gene

Localization for NOL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL4 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with NOL4: view

Pathways & Interactions for NOL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOL4 Gene

Transcripts for NOL4 Gene

Unigene Clusters for NOL4 Gene

Nucleolar protein 4:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: -
SP3: - - - -

Relevant External Links for NOL4 Gene

GeneLoc Exon Structure for
NOL4
ECgene alternative splicing isoforms for
NOL4

Expression for NOL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.5), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Cerebellar Hemisphere (x4.4), Brain - Cortex (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for NOL4 Gene

This gene is overexpressed in Frontal cortex (61.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NOL4 Gene



Protein tissue co-expression partners for NOL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOL4 Gene:

NOL4

SOURCE GeneReport for Unigene cluster for NOL4 Gene:

Hs.514795

mRNA Expression by UniProt/SwissProt for NOL4 Gene:

O94818-NOL4_HUMAN
Tissue specificity: Expressed predominantly in fetal brain, adult brain and testis.
genes like me logo Genes that share expression patterns with NOL4: view

Orthologs for NOL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOL4 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia NOL4 34 35
  • 94.88 (n)
cow
(Bos Taurus)
Mammalia NOL4 34 35
  • 93.36 (n)
oppossum
(Monodelphis domestica)
Mammalia NOL4 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nol4 34 16 35
  • 89.68 (n)
rat
(Rattus norvegicus)
Mammalia Nol4 34
  • 84.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NOL4 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOL4 35 34
  • 88.3 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOL4 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nol4 34
  • 80.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS01523.1 36
  • 75 (a)
CG17341 35
  • 24 (a)
OneToOne
Species where no ortholog for NOL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NOL4 Gene

ENSEMBL:
Gene Tree for NOL4 (if available)
TreeFam:
Gene Tree for NOL4 (if available)

Paralogs for NOL4 Gene

Paralogs for NOL4 Gene

(2) SIMAP similar genes for NOL4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NOL4: view

Variants for NOL4 Gene

Sequence variations from dbSNP and Humsavar for NOL4 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10083917 -- 33,940,171(+) cagaa(A/G)tacca intron-variant
rs10153396 -- 33,853,448(+) ATTTG(A/C)AATTT intron-variant
rs10221293 -- 34,218,829(+) TAACT(G/T)GGTCT intron-variant
rs10221379 -- 34,072,137(+) aaggc(A/C)ggaga intron-variant
rs10221380 -- 34,072,146(+) gaatc(A/G)cccgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOL4 Gene

Variant ID Type Subtype PubMed ID
nsv954942 CNV deletion 24416366
nsv576649 CNV loss 21841781
nsv576648 CNV loss 21841781
nsv576647 CNV loss 21841781
nsv576646 CNV loss 21841781
nsv576643 CNV gain 21841781
nsv519676 CNV gain 19592680
nsv470415 CNV gain 18288195
nsv458049 CNV loss 19166990
nsv458048 CNV loss 19166990
nsv132109 CNV insertion 16902084
nsv1150892 CNV deletion 26484159
nsv1134709 CNV deletion 24896259
nsv1071450 CNV deletion 25765185
esv3642183 CNV loss 21293372
esv3642182 CNV loss 21293372
esv3642181 CNV loss 21293372
esv3642180 CNV loss 21293372
esv3642176 CNV loss 21293372
esv3555212 CNV deletion 23714750
esv3348179 CNV insertion 20981092
esv3303199 CNV mobile element insertion 20981092
esv3222 CNV loss 18987735
esv2716952 CNV deletion 23290073
esv2670669 CNV deletion 23128226
esv2668525 CNV deletion 23128226
esv2663858 CNV deletion 23128226
esv2019786 CNV deletion 18987734
esv1694854 CNV deletion 17803354
esv1010069 CNV deletion 20482838
dgv58n6 CNV deletion 16902084

Variation tolerance for NOL4 Gene

Residual Variation Intolerance Score: 6.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL4 Gene

Disorders for NOL4 Gene

Relevant External Links for NOL4

Genetic Association Database (GAD)
NOL4
Human Genome Epidemiology (HuGE) Navigator
NOL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOL4

No disorders were found for NOL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL4 Gene

Publications for NOL4 Gene

  1. NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization. (PMID: 9813152) Ueki N. … Muramatsu M.-A. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 64
  2. A genomewide association study of citalopram response in major depressive disorder. (PMID: 19846067) Garriock H.A. … Hamilton S.P. (Biol. Psychiatry 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NOL4 Gene

Sources for NOL4 Gene

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