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Aliases for NOL4 Gene

Aliases for NOL4 Gene

  • Nucleolar Protein 4 2 3
  • Cancer/Testis Antigen 125 2 3
  • NOLP 3 4
  • Nucleolar Localized Protein 3
  • Nucleolar-Localized Protein 4
  • HRIHFB2255 3
  • CT125 3

External Ids for NOL4 Gene

Previous GeneCards Identifiers for NOL4 Gene

  • GC18M031465
  • GC18M031251
  • GC18M029684
  • GC18M029686
  • GC18M028290

Summaries for NOL4 Gene

GeneCards Summary for NOL4 Gene

NOL4 (Nucleolar Protein 4) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is NOL4L.

Gene Wiki entry for NOL4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL4 Gene

Genomics for NOL4 Gene

Regulatory Elements for NOL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NOL4 Gene

33,851,100 bp from pter
34,224,952 bp from pter
373,853 bases
Minus strand

Genomic View for NOL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL4 Gene

Proteins for NOL4 Gene

  • Protein details for NOL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 4
    Protein Accession:
    Secondary Accessions:
    • B4DSQ0
    • B7Z3Z7
    • F5H1E3
    • Q6IBS2
    • Q9BWF1

    Protein attributes for NOL4 Gene

    638 amino acids
    Molecular mass:
    71357 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH00313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAA34576.1; Type=Erroneous termination; Positions=38; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=BAA34576.1; Type=Frameshift; Positions=82; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL4 Gene


neXtProt entry for NOL4 Gene

Proteomics data for NOL4 Gene at MOPED

Post-translational modifications for NOL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for NOL4 Gene

Domains for NOL4 Gene

Protein Domains for NOL4 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOL4 Gene

Function for NOL4 Gene

Molecular function for NOL4 Gene

GENATLAS Biochemistry:
nucleolar protein 4

Gene Ontology (GO) - Molecular Function for NOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9813152
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NOL4: view

Phenotypes for NOL4 Gene

GenomeRNAi human phenotypes for NOL4:
genes like me logo Genes that share phenotypes with NOL4: view

Animal Model Products

miRNA for NOL4 Gene

miRTarBase miRNAs that target NOL4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOL4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL4 Gene

Localization for NOL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL4 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for NOL4 Gene COMPARTMENTS Subcellular localization image for NOL4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with NOL4: view

Pathways for NOL4 Gene

SuperPathways for NOL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL4 Gene


No data available for Pathways by source for NOL4 Gene

Transcripts for NOL4 Gene

Unigene Clusters for NOL4 Gene

Nucleolar protein 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOL4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: -
SP3: - - - -

Relevant External Links for NOL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOL4 Gene

mRNA expression in normal human tissues for NOL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOL4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.5), Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Cerebellar Hemisphere (4.4), Brain - Cortex (4.1), and Brain - Nucleus accumbens (basal ganglia) (4.0).

Protein differential expression in normal tissues for NOL4 Gene

This gene is overexpressed in Frontal cortex (61.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NOL4 Gene

SOURCE GeneReport for Unigene cluster for NOL4 Gene Hs.514795

mRNA Expression by UniProt/SwissProt for NOL4 Gene

Tissue specificity: Expressed predominantly in fetal brain, adult brain and testis.
genes like me logo Genes that share expressions with NOL4: view

Expression partners for NOL4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for NOL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOL4 35
  • 93.36 (n)
  • 97.18 (a)
NOL4 36
  • 97 (a)
(Canis familiaris)
Mammalia NOL4 35
  • 94.88 (n)
  • 97.18 (a)
NOL4 36
  • 97 (a)
(Mus musculus)
Mammalia Nol4 35
  • 89.68 (n)
  • 93.81 (a)
Nol4 16
Nol4 36
  • 92 (a)
(Pan troglodytes)
Mammalia NOL4 35
  • 99.63 (n)
  • 100 (a)
NOL4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nol4 35
  • 84.06 (n)
  • 87.78 (a)
(Monodelphis domestica)
Mammalia NOL4 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia NOL4 36
  • 81 (a)
(Gallus gallus)
Aves NOL4 35
  • 88.3 (n)
  • 93.64 (a)
NOL4 36
  • 79 (a)
(Anolis carolinensis)
Reptilia NOL4 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nol4 35
  • 80.75 (n)
  • 85.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS01523.1 37
  • 75 (a)
CG17341 36
  • 24 (a)
Species with no ortholog for NOL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NOL4 Gene

Gene Tree for NOL4 (if available)
Gene Tree for NOL4 (if available)

Paralogs for NOL4 Gene

Paralogs for NOL4 Gene

(2) SIMAP similar genes for NOL4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NOL4: view

Variants for NOL4 Gene

Sequence variations from dbSNP and Humsavar for NOL4 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs11873627 -- 34,059,821(+) TGTGC(A/T)GAGAC intron-variant, upstream-variant-2KB
rs11873653 -- 34,059,878(+) AGAGA(A/G)ACAGA intron-variant, upstream-variant-2KB
rs11874209 -- 34,007,933(+) gactg(C/T)gctat intron-variant
rs11874351 -- 34,113,005(+) acagg(A/G)tctct intron-variant
rs11874389 -- 34,060,144(+) aataa(A/G)taatt intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NOL4 Gene

Variant ID Type Subtype PubMed ID
esv2668525 CNV Deletion 23128226
nsv458048 CNV Loss 19166990
nsv909531 CNV Gain 21882294
nsv909532 CNV Loss 21882294
esv267479 CNV Insertion 20981092
nsv132109 CNV Insertion 16902084
esv2670669 CNV Deletion 23128226
nsv458049 CNV Loss 19166990
nsv909533 CNV Loss 21882294
nsv909534 CNV Loss 21882294
nsv470415 CNV Gain 18288195
nsv909535 CNV Gain 21882294
esv2019786 CNV Deletion 18987734
esv3222 CNV Deletion 18987735
esv2716952 CNV Deletion 23290073
esv1010069 CNV Deletion 20482838
dgv58n6 CNV Loss 16902084
esv1694854 CNV Deletion 17803354
nsv519676 CNV Gain 19592680
esv2663858 CNV Deletion 23128226

Relevant External Links for NOL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL4 Gene

Disorders for NOL4 Gene

Relevant External Links for NOL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for NOL4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NOL4 Gene

Publications for NOL4 Gene

  1. NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization. (PMID: 9813152) Ueki N. … Muramatsu M.-A. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. Selection system for genes encoding nuclear-targeted proteins. (PMID: 9853615) Ueki N. … Muramatsu M.-A. (Nat. Biotechnol. 1998) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NOL4 Gene

Sources for NOL4 Gene

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