Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NOL3 Gene

protein-coding   GIFtS: 64
GCID: GC16P067207

Nucleolar Protein 3 (Apoptosis Repressor With CARD Domain)

  See NOL3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nucleolar Protein 3 (Apoptosis Repressor With CARD Domain)1 2     NOP302
ARC2 3 5     Nucleolar Protein 32
NOP2 3 5     Myp3
Muscle-Enriched Cytoplasmic Protein2 3     Nop303
Nucleolar Protein Of 30 KDa2 3     Apoptosis Repressor With CARD3
FCM2 5     MYC5
MYP2     

External Ids:    HGNC: 78691   Entrez Gene: 89962   Ensembl: ENSG000001409397   OMIM: 6052355   UniProtKB: O609363   

Export aliases for NOL3 gene to outside databases

Previous GC identifers: GC16P057902 GC16P067585 GC16P066943 GC16P066984 GC16P065765 GC16P053077


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NOL3 Gene:
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase
2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for NOL3 Gene:
NOL3 (nucleolar protein 3 (apoptosis repressor with CARD domain)) is a protein-coding gene. Diseases associated with NOL3 include pain agnosia, and myoclonus, familial cortical. GO annotations related to this gene include RNA binding and identical protein binding.

UniProtKB/Swiss-Prot: NOL3_HUMAN, O60936
Function: Isoform 1 may be involved in RNA splicing
Function: Isoform 2 may inhibit apoptosis

Gene Wiki entry for NOL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOL3 gene promoter:
         p53   AP-1   ATF-2   MyoD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NOL3 promoter sequence
   Search Chromatin IP Primers for NOL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

NOL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOL3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067207:  view genomic region     (about GC identifiers)

Start:
67,204,057 bp from pter      End:
67,209,643 bp from pter
Size:
5,587 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NOL3_HUMAN, O60936 (See protein sequence)
Recommended Name: Nucleolar protein 3  
Size: 219 amino acids; 24327 Da
Subunit: Interacts with TFPT (By similarity). Isoform 1 oligomerizes and binds to SFRS9/SRp30C and also interacts
with NPM1. Isoform 2 binds CASP2/caspase-2 and CASP8/caspase-8 and inhibits caspase-8 activity
Secondary accessions: O60937
Alternative splicing: 2 isoforms:  O60936-1   O60936-2   

Explore the universe of human proteins at neXtProt for NOL3: NX_O60936

Explore proteomics data for NOL3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NOL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001263248.1  NP_001171986.1  NP_001263236.1  NP_001263238.1  NP_001263240.1  NP_001263241.1  NP_003937.1  NP_001171987.1  

    ENSEMBL proteins: 
     ENSP00000457732   ENSP00000454256   ENSP00000457720   ENSP00000457243   ENSP00000455808  
     ENSP00000463698   ENSP00000454598   ENSP00000463685   ENSP00000399831   ENSP00000268605  

    NOL3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NOL3 (ARC)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for NOL3
    OriGene Protein Over-expression Lysate for NOL3
    OriGene MassSpec for NOL3
    OriGene Custom Protein Services for NOL3
    GenScript Custom Purified and Recombinant Proteins Services for NOL3
    Novus Biologicals NOL3 Proteins
    Novus Biologicals NOL3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NOL3
    Cloud-Clone Corp. Proteins for NOL3

     
    Search eBioscience for Proteins for NOL3 

    NOL3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NOL3 (ARC)
    OriGene Antibodies for NOL3
    OriGene Custom Antibody Services for NOL3
    Novus Biologicals NOL3 Antibodies
    Abcam antibodies for NOL3
    Cloud-Clone Corp. Antibodies for NOL3
    ThermoFisher Antibody for NOL3
    LSBio Antibodies in human, mouse, rat for NOL3

    NOL3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NOL3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NOL3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NOL3
    Cloud-Clone Corp. CLIAs for NOL3
    Search eBioscience for ELISAs for NOL3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry O60936

    ProtoNet protein and cluster: O60936

    1 Blocks protein domain: IPB001315 CARD interaction domain

    UniProtKB/Swiss-Prot: NOL3_HUMAN, O60936
    Similarity: Contains 1 CARD domain


    Find genes that share domains with NOL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOL3_HUMAN, O60936
    Function: Isoform 1 may be involved in RNA splicing
    Function: Isoform 2 may inhibit apoptosis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS10196175
    GO:0005515protein binding IPI18087040
    GO:0042802identical protein binding IPI16189514
         
    Find genes that share ontologies with NOL3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NOL3:
     Increased cell death HMECs cel  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nol3):
     cardiovascular system  cellular  homeostasis/metabolism  muscle  respiratory system 

    Find genes that share phenotypes with NOL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NOL3: Nol3tm1.1Rnkt Nol3tm1Rvh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOL3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOL3:
    hsa-mir-378a-5p (MIRT043974)

    Block miRNA regulation of human, mouse, rat NOL3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate NOL3:
    hsa-miR-579 hsa-miR-644 hsa-miR-612 hsa-miR-147 hsa-miR-1285 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidNOL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOL3
    Predesigned siRNA for gene silencing in human, mouse, rat NOL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOL3

    Clone
    Products:
         
    OriGene clones in human, mouse for NOL3 (see all 9)
    OriGene ORF clones in mouse, rat for NOL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NOL3 (NM_003946)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NOL3
    Browse ESI BIO Cell Lines and PureStem Progenitors for NOL3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NOL3_HUMAN, O60936: Isoform 1: Nucleus, nucleolus
    NOL3_HUMAN, O60936: Isoform 2: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005730nucleolus IEA--
    GO:0005739mitochondrion ISS--
    GO:0005829cytosol TAS10196175
    GO:0016528sarcoplasm IEA--

    Find genes that share ontologies with NOL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NOL3 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis Signaling Pathways
    Apoptosis Signaling Pathways0.35
    2Selected targets of p53
    Selected targets of p53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NOL3
        Apoptosis Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NOL3
        Glucocorticoid Receptor Signaling

    1 Tocris Bioscience Pathway for NOL3
        Notch Pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOL3: 
              Cancer PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NOL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOL3 (O609361, 2, 3 ENSP000002686054) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP8Q147901, 3, ENSP000003512734EBI-740992,EBI-78060 I2D: score=3 STRING: ENSP00000351273
    NOL3O609361, 2EBI-740992,EBI-740992 MINT-66132
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-67450 I2D: score=5 STRING: ENSP00000386394
    VASPP505522, 3, ENSP000002459324MINT-67223 I2D: score=5 STRING: ENSP00000245932
    ETNK2Q9NVF93, ENSP000003561704I2D: score=4 STRING: ENSP00000356170
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006915apoptotic process IEA--
    GO:0008380RNA splicing IEA--
    GO:0042981regulation of apoptotic process ----
    GO:0043066negative regulation of apoptotic process TAS9560245

    Find genes that share ontologies with NOL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOL3

    2 Novoseek inferred chemical compound relationships for NOL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 41.2 1 9560245 (1)
    glutamate 18.1 1 9560245 (1)



    Find genes that share compounds with NOL3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NOL3 gene (8 alternative transcripts): 
    NM_001276319.1  NM_001185057.2  NM_001276307.1  NM_001276309.1  NM_001276311.1  NM_001276312.1  NM_003946.6  NM_001185058.1  

    Unigene Cluster for NOL3:

    Nucleolar protein 3 (apoptosis repressor with CARD domain)
    Hs.513667  [show with all ESTs]
    Unigene Representative Sequence: BX537925
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565560 ENST00000563439 ENST00000568086 ENST00000564992 ENST00000564053
    ENST00000565645 ENST00000568199 ENST00000566871 ENST00000568503 ENST00000563258
    ENST00000568146 ENST00000564860 ENST00000432069(uc010vjc.2 uc002erp.3 uc010vjd.2)
    ENST00000268605
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NOL3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate NOL3:
    hsa-miR-579 hsa-miR-644 hsa-miR-612 hsa-miR-147 hsa-miR-1285 hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidNOL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NOL3
    Predesigned siRNA for gene silencing in human, mouse, rat NOL3
    Clone
    Products:
         
    OriGene clones in human, mouse for NOL3 (see all 9)
    OriGene ORF clones in mouse, rat for NOL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NOL3 (NM_003946)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NOL3
    OriGene qSTAR qPCR primer pairs in human, mouse for NOL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOL3
      QuantiTect SYBR Green Assays in human, mouse, rat NOL3
      QuantiFast Probe-based Assays in human, mouse, rat NOL3

    Additional mRNA sequence: 

    AF043244.1 AF064599.1 AF064600.1 AK294145.1 AK314899.1 BC012798.2 BT020158.1 BX537901.1 
    BX537925.1 

    12 DOTS entries:

    DT.215991  DT.100828929  DT.95231356  DT.100044753  DT.100691684  DT.120721835  DT.120721960  DT.95149414 
    DT.100828934  DT.40122961  DT.100663285  DT.86855029 

    Selected AceView cDNA sequences (see all 123):

    BM742436 BM700578 AF064599 C00358 BQ671991 BU785633 BQ574593 CR611049 
    BQ004339 BQ686699 BU180260 CA941097 BU689313 AI564827 BC012798 BM510745 
    AI751561 BQ685512 AF064600 CR600491 CN485303 BU622537 BG910173 CA488108 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NOL3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
    SP1:                                            -                                       
    SP2:                                -     -     -                                       
    SP3:                                      -     -                                       
    SP4:                                            -                                       
    SP5:                                                                                    


    ECgene alternative splicing isoforms for NOL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NOL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCAAGGGG
    NOL3 Expression
    About this image

    NOL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513667

    UniProtKB/Swiss-Prot: NOL3_HUMAN, O60936
    Tissue specificity: Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver,
    kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOL3: 
              Cancer PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NOL3
    OriGene qSTAR qPCR primer pairs in human, mouse for NOL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOL3
    QuantiTect SYBR Green Assays in human, mouse, rat NOL3
    QuantiFast Probe-based Assays in human, mouse, rat NOL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for NOL3 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nol31 , 5 nucleolar protein 3 (apoptosis repressor with CARD more1, 5 83.67(n)1
    87.92(a)1
      8 (53.04 cM)5
    786881  NM_030152.41  NP_084428.11 
     1052764475 


    ENSEMBL Gene Tree for NOL3 (if available)
    TreeFam Gene Tree for NOL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NOL3 (see all 108)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0697314
    Myoclonus, familial cortical (FCM)4--see VAR_0697312 E Q mis40--------
    rs99271281,2
    C,F,A,H--67204388(+) CTGGCC/TGCCCC 5 -- us2k15Minor allele frequency- T:0.06NS EA NA 420
    rs1125511891,2
    C--67204681(+) GGGGCG/-CGGGG 5 -- int11Minor allele frequency- -:0.50CSA 2
    rs3758740271,2
    C--67204689(+) GGGGG-/A/G/GA
            
    AAAAT
    5 -- int10--------
    rs3705350351,2
    C--67204690(+) GGGGG-/AAAATC 5 -- int10--------
    rs1466997161,2
    C--67205322(+) TTAGCA/GATCAG 5 -- ut51 int10--------
    rs620579511,2
    C,F--67205352(+) GTGCCG/AGAGGC 5 -- ut51 int11Minor allele frequency- A:0.00NA 2
    rs1439916331,2
    C--67205373(+) CTCCGA/GTCCCT 5 -- int10--------
    rs1449202701,2
    --67205412(+) TGGCTA/GTCCAG 5 -- int10--------
    rs1917508781,2
    --67205486(+) GGTGTG/TGGGGG 5 -- int10--------

    HapMap Linkage Disequilibrium report for NOL3 (67204057 - 67209643 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NOL3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2887n71CNV Loss21882294
    dgv2888n71CNV Loss21882294
    nsv906794CNV Loss21882294
    nsv906803CNV Loss21882294
    dgv2886n71CNV Loss21882294
    nsv524492CNV Loss19592680
    nsv827707CNV Loss20364138
    dgv2885n71CNV Loss21882294
    nsv524363CNV Loss19592680
    nsv471092CNV Gain18288195

    Human Gene Mutation Database (HGMD): NOL3
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NOL3
    DNA2.0 Custom Variant and Variant Library Synthesis for NOL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605235   
    OMIM disorders: 614937  
    UniProtKB/Swiss-Prot: NOL3_HUMAN, O60936
  • Myoclonus, familial cortical (FCM) [MIM:614937]: An autosomal dominant neurologic condition characterized
    by adult onset of cortical myoclonus manifest as involuntary jerks or movements affecting the face and limbs.
    Affected individuals can also experience falls without seizure activity or loss of consciousness. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for NOL3:    
    About MalaCards
    pain agnosia    myoclonus, familial cortical    agnosia    myoclonus

    1 disease from the University of Copenhagen DISEASES database for NOL3:
    Pain agnosia

    Find genes that share disorders with NOL3           About GenesLikeMe

    Genetic Association Database (GAD): NOL3
    Human Genome Epidemiology (HuGE) Navigator: NOL3 (4 documents)

    Export disorders for NOL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NOL3 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with NOL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. (PubMed id 9560245)1, 2, 3, 9 Koseki T.... Nunez G. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. (PubMed id 10196175)1, 2, 9 Stoss O.... Stamm S. (J. Biol. Chem. 1999)
    3. Familial cortical myoclonus with a mutation in NOL3. (PubMed id 22926851)1, 2 Russell J.F....PtA!A8ek L.J. (Ann. Neurol. 2012)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Caspase-8 and its inhibitors in RCCs in vivo: the prominent role of ARC. (PubMed id 18516683)1, 9 Heikaus S....Ramp U. (Apoptosis 2008)
    8. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. (PubMed id 15383280)1, 9 Nam Y.J....Kitsis R.N. (Mol. Cell 2004)
    9. The apoptosis inhibitor ARC alleviates the ER stress response to promote I^-cell survival. (PubMed id 22933109)1 McKimpson W.M....Kitsis R.N. (Diabetes 2013)
    10. Hypoxia-inducible factor 1 regulated ARC expression mediated hypoxia induced inactivation of the intrinsic death pathway in p53 deficient human colon cancer cells. (PubMed id 22475487)1 Ao J.E....Yang C.M. (Biochem. Biophys. Res. Commun. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8996 HGNC: 7869 AceView: NOL3 Ensembl:ENSG00000140939 euGenes: HUgn8996
    ECgene: NOL3 H-InvDB: NOL3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NOL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NOL3 gene:
    Search GeneIP for patents involving NOL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for NOL3 (ARC)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for NOL3 (ARC)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NOL3   OriGene RNAi products in human, mouse, rat for NOL3  
     OriGene qPCR primer pairs and template standards for NOL3   OriGene Protein Over-expression Lysate for NOL3  
     OriGene MassSpec something-or-other for NOL3   OriGene clones in human, mouse for NOL3  
     OriGene qSTAR qPCR primer pairs in human, mouse for NOL3   OriGene Purified Protein for NOL3  
     OriGene ORF clones in mouse, rat for NOL3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NOL3   OriGene Custom Protein Services for NOL3  

     
     
     Block miRNA regulation of human, mouse, rat NOL3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NOL3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOL3 Predesigned siRNA for gene silencing in human, mouse, rat NOL3
     QuantiFast Probe-based Assays in human, mouse, rat NOL3 QuantiTect SYBR Green Assays in human, mouse, rat NOL3
     PCR Arrays including human, mouse, rat NOL3 Search Chromatin IP Primers for NOL3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOL3  GeneGlobe Interaction Network for NOL3
     Regulatory tfbs in NOL3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NOL3 GenScript cDNA clones with any tag delivered in your preferred vector for NOL3
     GenScript Custom Assay Services for NOL3 GenScript Custom overexpressing Cell Line Services for NOL3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NOL3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NOL3 antibodies
     NOL3 proteins
     NOL3 lysates
     Antibodies for NOL3
     See all of Abcam's Antibodies, Kits and Proteins for NOL3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NOL3
     Proteins for NOL3
     Antibodies for NOL3
     ELISAs for NOL3
     CLIAs for NOL3



     Browse ESI BIO Cell Lines and PureStem Progenitors for NOL3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL3
     SwitchGear 3'UTR luciferase reporter plasmids for NOL3
     SwitchGear Promoter luciferase reporter plasmids for NOL3
     ThermoFisher Antibody for NOL3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOL3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NOL3
     LSBio Antibodies in human, mouse, rat for NOL3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NOL3
      Search eBioscience for proteins for NOL3
      Search eBioscience for elisas for NOL3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NOL3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4