NOL12 Gene
protein-coding GIFtS: 43
GCID: GC22P038077
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nucleolar protein 12
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Aliases
for NOL12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleolar Protein 121 2 | | Nop251 2 | | MGC37311 | | RRP171 | | DJ37E16.71 |
Export aliases for NOL12 gene to outside databasesPrevious GC identifers: GC22P036412 GC22P021049 GC22P038082 |
Summaries
for NOL12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NOL12_HUMAN, Q9UGY1Function: May bind to 28S rRNA (By similarity)
Gene Wiki entry for NOL12
|
Genomic Views
for NOL12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOL12 gene promoter:
p53 AP-1 MyoD CBF-C YY1 HEN1 PPAR-gamma1 CBF-A PPAR-gamma2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOL12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOL12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1NOL12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P038077: view genomic region
(about GC identifiers)
Start:
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38,077,680 bp from pter |
End:
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38,089,485 bp from pter |
Size:
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11,806 bases |
Orientation:
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plus strand |
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Proteins
for NOL12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOL12_HUMAN, Q9UGY1 (See
protein sequence)Recommended Name: Nucleolar protein 12 Size: 213 amino acids; 24663 Da
Subunit: Interacts with KIAA1191
Subcellular location: Nucleus, nucleolus (By similarity)Explore the universe of human proteins at neXtProt for NOL12: NX_Q9UGY1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UGY1
NOL12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_077289.1
ENSEMBL proteins: ENSP00000352021 ENSP00000403059
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
NOL12 for ontologies About GeneDecksing
NOL12 Antibody Products:
Assay Products for NOL12: |
Protein
Domains /
Families
for NOL12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOL12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UGY1ProtoNet protein and cluster: Q9UGY1 UniProtKB/Swiss-Prot: NOL12_HUMAN, Q9UGY1Similarity: Belongs to the RRP17 family |
Function
for NOL12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NOL12_HUMAN, Q9UGY1Function: May bind to 28S rRNA (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NOL12 (NM_024313) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOL12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL12 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019843 | rRNA binding |
IEA | -- |
NOL12 for ontologies About GeneDecksing
|
Pathways & Interactions
for NOL12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOL12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/19 Interacting proteins for NOL12 (Q9UGY13 ENSP000003520214) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
|
Drugs & Compounds
for NOL12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NOL12
Search CenterWatch for drugs/clinical trials and news about NOL12
|
Transcripts
for NOL12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOL12 gene: NM_024313.2 Unigene Cluster for NOL12: Nucleolar protein 12 Hs.632778 [show with all ESTs]Unigene Representative Sequence: NM_0243136 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000493862 ENST00000359114(uc003atp.3) ENST00000438329(uc011anm.1 uc003ato.1)
ENST00000474032 ENST00000468597 ENST00000484650
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NOL12 (NM_024313) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOL12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL12 |
Additional cDNA sequence: AK057139.1 AK091928.1 AK294700.1 AK310084.1 AK316443.1 AL160132.1 BC002808.1 CR456463.1 14 DOTS entries: DT.312353 DT.99950852 DT.100793156 DT.95207173 DT.120660892 DT.92050674 DT.120660884 DT.100014590 DT.40232095 DT.100712021 DT.120660797 DT.120660918 DT.120660820 DT.91938279 24/1106 AceView cDNA sequences (see all 1106): AA039476 BQ053431 BQ053195 BF793277 AW239224 CD671187 AA303984 AW239423 AI824457 BU507153 CK429254 BE267515 CB137923 BE887142 CD368432 CD723793 BM667055 BM850089 BQ004762 CN481448 BM692666 BM798715 BU733972 BM768739
GeneLoc Exon Structure
|
Expression
for NOL12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOL12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCCGCTGC
About this image
See NOL12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOL12
SOURCE GeneReport for Unigene cluster: Hs.632778
SABiosciences Custom PCR Arrays for NOL12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOL12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOL12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOL12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOL12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL12 |
Orthologs
for NOL12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NOL12 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for NOL12 (if available)
TreeFam Gene Tree for NOL12 (if available) |
Paralogs
for NOL12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NOL12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NOL12 (38077680 - 38089485 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NOL12
1 CNV: 4128 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for NOL12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NOL12 for disorders About GeneDecksing
1  disease for NOL12: About MalaCardshearing loss
Human Genome Epidemiology (HuGE) Navigator: NOL12 (3 documents)
Export disorders for NOL12 gene to outside databases
|
Publications
for NOL12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOL12 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with NOL12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Characterizing the novel protein p33MONOX. (PubMed id 21153684)2 Mishra M....Heese K. (2011)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
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External Searches for NOL12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NOL12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOL12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOL12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOL12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NOL12 gene:
Search GeneIP for patents involving NOL12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOL12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NOL12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOL12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOL12 | | | OriGene Protein Over-expression Lysate for NOL12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NOL12 | | OriGene 3'-UTR Clone for NOL12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NOL12 | | OriGene Custom Protein Services for NOL12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOL12 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOL12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOL12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOL12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOL12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOL12 |
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 |  |  |  | |
| | | | Search Tocris compounds for NOL12 |
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 | | | NOL12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL12 |
|  |  |  | | | | Search ThermoFisher Antibodies for NOL12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL12 |
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