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Aliases for NOL12 Gene

Aliases for NOL12 Gene

  • Nucleolar Protein 12 2 3 5
  • DJ37E16.7 3
  • Nop25 3

External Ids for NOL12 Gene

Previous GeneCards Identifiers for NOL12 Gene

  • GC22P036412
  • GC22P038077
  • GC22P021049
  • GC22P038082

Summaries for NOL12 Gene

GeneCards Summary for NOL12 Gene

NOL12 (Nucleolar Protein 12) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and rRNA binding. An important paralog of this gene is ENSG00000100101.

UniProtKB/Swiss-Prot for NOL12 Gene

  • May bind to 28S rRNA.

Gene Wiki entry for NOL12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL12 Gene

Genomics for NOL12 Gene

Regulatory Elements for NOL12 Gene

Enhancers for NOL12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NOL12 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOL12 Gene

37,681,673 bp from pter
37,693,478 bp from pter
11,806 bases
Plus strand

Genomic View for NOL12 Gene

Genes around NOL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL12 Gene

Proteins for NOL12 Gene

  • Protein details for NOL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 12
    Protein Accession:

    Protein attributes for NOL12 Gene

    213 amino acids
    Molecular mass:
    24663 Da
    Quaternary structure:
    • Interacts with KIAA1191.

neXtProt entry for NOL12 Gene

Post-translational modifications for NOL12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOL12 Gene

Domains & Families for NOL12 Gene

Protein Domains for NOL12 Gene


Suggested Antigen Peptide Sequences for NOL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRP17 family.
  • Belongs to the RRP17 family.
genes like me logo Genes that share domains with NOL12: view

No data available for Gene Families for NOL12 Gene

Function for NOL12 Gene

Molecular function for NOL12 Gene

UniProtKB/Swiss-Prot Function:
May bind to 28S rRNA.

Gene Ontology (GO) - Molecular Function for NOL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0019843 rRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOL12: view
genes like me logo Genes that share phenotypes with NOL12: view

Animal Model Products

CRISPR Products

miRNA for NOL12 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL12 Gene

Localization for NOL12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL12 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for NOL12 Gene COMPARTMENTS Subcellular localization image for NOL12 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for NOL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with NOL12: view

Pathways & Interactions for NOL12 Gene

SuperPathways for NOL12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL12 Gene


No data available for Pathways by source and SIGNOR curated interactions for NOL12 Gene

Drugs & Compounds for NOL12 Gene

No Compound Related Data Available

Transcripts for NOL12 Gene

Unigene Clusters for NOL12 Gene

Nucleolar protein 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL12 Gene

No ASD Table

Relevant External Links for NOL12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOL12 Gene

mRNA expression in normal human tissues for NOL12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOL12 Gene

This gene is overexpressed in Lung (44.4) and Adrenal (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL12 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOL12 Gene:


SOURCE GeneReport for Unigene cluster for NOL12 Gene:

genes like me logo Genes that share expression patterns with NOL12: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NOL12 Gene

Orthologs for NOL12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOL12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOL12 34
  • 88.99 (n)
  • 90.57 (a)
(Canis familiaris)
Mammalia NOL12 34
  • 88.58 (n)
  • 92.96 (a)
(Mus musculus)
Mammalia Nol12 34
  • 86.23 (n)
  • 91.08 (a)
Nol12 16
(Pan troglodytes)
Mammalia NOL12 34
  • 98.75 (n)
  • 98.12 (a)
(Rattus norvegicus)
Mammalia Nol12 34
  • 85.29 (n)
  • 89.67 (a)
(Gallus gallus)
Aves NOL12 34
  • 67.32 (n)
  • 67.49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nol12 34
  • 59.74 (n)
  • 61.88 (a)
Str.879 34
(Danio rerio)
Actinopterygii nol12 34
  • 61.2 (n)
  • 57.92 (a)
zgc56457 34
Species where no ortholog for NOL12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL12 Gene

Gene Tree for NOL12 (if available)
Gene Tree for NOL12 (if available)

Paralogs for NOL12 Gene

Paralogs for NOL12 Gene

genes like me logo Genes that share paralogs with NOL12: view

Variants for NOL12 Gene

Sequence variations from dbSNP and Humsavar for NOL12 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs743837 -- 37,689,516(-) CTACT(C/T)ATGAT intron-variant
rs762990 -- 37,689,468(+) CTGGC(A/G)CGTCT intron-variant
rs13058368 -- 37,690,347(+) AAAAC(A/C)AAACC intron-variant
rs6000861 -- 37,688,397(+) CAGCT(A/C/G)ATGGG intron-variant
rs6000862 -- 37,689,544(+) AAAAA(A/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOL12 Gene

Variant ID Type Subtype PubMed ID
esv2758838 CNV loss 17122850
esv3647715 CNV loss 21293372
nsv1057617 CNV gain 25217958
nsv471197 CNV loss 18288195
nsv528985 CNV loss 19592680
nsv829203 CNV loss 20364138
nsv834191 CNV loss 17160897

Variation tolerance for NOL12 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL12 Gene

Disorders for NOL12 Gene

Relevant External Links for NOL12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL12 Gene

Publications for NOL12 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 65

Products for NOL12 Gene

Sources for NOL12 Gene

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