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Aliases for NOL11 Gene

Aliases for NOL11 Gene

  • Nucleolar Protein 11 2 3 5

External Ids for NOL11 Gene

Previous GeneCards Identifiers for NOL11 Gene

  • GC17P063145
  • GC17P065714
  • GC17P061098

Summaries for NOL11 Gene

GeneCards Summary for NOL11 Gene

NOL11 (Nucleolar Protein 11) is a Protein Coding gene. Diseases associated with NOL11 include Dravet Syndrome. Among its related pathways are rRNA processing and Gene Expression. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for NOL11 Gene

  • Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A, A0, 1 and 2b.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL11 Gene

Genomics for NOL11 Gene

Regulatory Elements for NOL11 Gene

Enhancers for NOL11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NOL11 on UCSC Golden Path with GeneCards custom track

Promoters for NOL11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NOL11 Gene

Chromosome:
17
Start:
67,717,833 bp from pter
End:
67,744,531 bp from pter
Size:
26,699 bases
Orientation:
Plus strand

Genomic View for NOL11 Gene

Genes around NOL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL11 Gene

Proteins for NOL11 Gene

  • Protein details for NOL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8H0-NOL11_HUMAN
    Recommended name:
    Nucleolar protein 11
    Protein Accession:
    Q9H8H0
    Secondary Accessions:
    • B7Z5V9
    • Q7L5S1
    • Q9UG18

    Protein attributes for NOL11 Gene

    Size:
    719 amino acids
    Molecular mass:
    81124 Da
    Quaternary structure:
    • Forms a complex with UTP4, UTP15, WDR43 and WDR75; within this complex, directly interacts with UTP4. Interacts with FBL/fibrillarin in a transcription-dependent manner.
    SequenceCaution:
    • Sequence=BAH13045.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAB53709.1; Type=Frameshift; Positions=382, 383; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL11 Gene

Post-translational modifications for NOL11 Gene

  • Ubiquitination at Lys 52, Lys 125, Lys 252, Lys 344, Lys 424, and Lys 676
  • Modification sites at PhosphoSitePlus

Other Protein References for NOL11 Gene

No data available for DME Specific Peptides for NOL11 Gene

Domains & Families for NOL11 Gene

Protein Domains for NOL11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NOL11 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL11: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOL11 Gene

Function for NOL11 Gene

Molecular function for NOL11 Gene

UniProtKB/Swiss-Prot Function:
Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A, A0, 1 and 2b.

Gene Ontology (GO) - Molecular Function for NOL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22916032
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOL11: view
genes like me logo Genes that share phenotypes with NOL11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL11 Gene

Localization for NOL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL11 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOL11 Gene COMPARTMENTS Subcellular localization image for NOL11 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NOL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 22916032
GO:0034455 t-UTP complex IDA 22916032
genes like me logo Genes that share ontologies with NOL11: view

Pathways & Interactions for NOL11 Gene

genes like me logo Genes that share pathways with NOL11: view

Pathways by source for NOL11 Gene

Interacting Proteins for NOL11 Gene

Gene Ontology (GO) - Biological Process for NOL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006364 rRNA processing TAS --
GO:0030490 maturation of SSU-rRNA IMP 22916032
GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter IMP 22916032
genes like me logo Genes that share ontologies with NOL11: view

No data available for SIGNOR curated interactions for NOL11 Gene

Drugs & Compounds for NOL11 Gene

No Compound Related Data Available

Transcripts for NOL11 Gene

Unigene Clusters for NOL11 Gene

Nucleolar protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL11 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for NOL11 Gene

GeneLoc Exon Structure for
NOL11
ECgene alternative splicing isoforms for
NOL11

Expression for NOL11 Gene

mRNA expression in normal human tissues for NOL11 Gene

Protein differential expression in normal tissues from HIPED for NOL11 Gene

This gene is overexpressed in Breast (25.9), CD8 Tcells (7.1), Peripheral blood mononuclear cells (6.7), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL11 Gene



Protein tissue co-expression partners for NOL11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOL11 Gene:

NOL11

SOURCE GeneReport for Unigene cluster for NOL11 Gene:

Hs.463936
genes like me logo Genes that share expression patterns with NOL11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOL11 Gene

Orthologs for NOL11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOL11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOL11 34
  • 86.58 (n)
  • 84.4 (a)
NOL11 35
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOL11 34
  • 88.22 (n)
  • 85.2 (a)
NOL11 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nol11 34
  • 80.56 (n)
  • 77.44 (a)
Nol11 16
Nol11 35
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOL11 34
  • 99.63 (n)
  • 99.86 (a)
NOL11 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nol11 34
  • 78.38 (n)
  • 73.27 (a)
oppossum
(Monodelphis domestica)
Mammalia NOL11 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOL11 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859426 34
  • 64.63 (n)
  • 57.73 (a)
NOL11 35
  • 53 (a)
OneToMany
NOL11 35
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NOL11 35
  • 51 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15994 34
zebrafish
(Danio rerio)
Actinopterygii nol11 34
  • 52.55 (n)
  • 41.07 (a)
nol11 35
  • 38 (a)
OneToOne
Species where no ortholog for NOL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL11 Gene

ENSEMBL:
Gene Tree for NOL11 (if available)
TreeFam:
Gene Tree for NOL11 (if available)

Paralogs for NOL11 Gene

Pseudogenes.org Pseudogenes for NOL11 Gene

genes like me logo Genes that share paralogs with NOL11: view

No data available for Paralogs for NOL11 Gene

Variants for NOL11 Gene

Sequence variations from dbSNP and Humsavar for NOL11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2291284 - 67,721,409(-) CTTGC(A/G)CTGAA reference, missense, utr-variant-5-prime
rs10127 -- 67,743,511(-) AAATT(C/T)GCATC reference, synonymous-codon
rs191128 -- 67,723,371(-) AAAAA(A/T)TTAGA intron-variant
rs999041 -- 67,722,818(-) GCTAC(A/G)AGGCA intron-variant
rs999042 -- 67,722,758(-) GCAGT(G/T)AACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOL11 Gene

Variant ID Type Subtype PubMed ID
dgv1499n106 CNV deletion 24896259
esv1406871 CNV deletion 17803354
esv2209241 CNV deletion 18987734
esv2556372 CNV deletion 19546169
esv3554684 CNV deletion 23714750
esv3806 CNV loss 18987735
esv3893036 CNV gain 25118596
esv7392 CNV loss 19470904
nsv1066511 CNV gain 25217958
nsv1071400 CNV deletion 25765185
nsv1120054 OTHER inversion 24896259
nsv1146861 CNV deletion 26484159
nsv510442 OTHER sequence alteration 20534489
nsv511059 OTHER complex 20534489
nsv575915 CNV gain 21841781
nsv955416 CNV deletion 24416366

Variation tolerance for NOL11 Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL11 Gene

Disorders for NOL11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NOL11 Gene - From: GeneCards

Disorder Aliases PubMed IDs
dravet syndrome
  • dravet syndrome, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search NOL11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOL11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOL11
genes like me logo Genes that share disorders with NOL11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOL11 Gene

Publications for NOL11 Gene

  1. NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing. (PMID: 22916032) Freed E.F. … Baserga S.J. (PLoS Genet. 2012) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65

Products for NOL11 Gene

Sources for NOL11 Gene

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