Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NOL11 Gene

Aliases for NOL11 Gene

  • Nucleolar Protein 11 2 3

External Ids for NOL11 Gene

Summaries for NOL11 Gene

GeneCards Summary for NOL11 Gene

NOL11 (Nucleolar Protein 11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NOL11 Gene

  • Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A, A0, 1 and 2b.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL11 Gene

Genomics for NOL11 Gene

Genomic Location for NOL11 Gene

Start:
67,717,833 bp from pter
End:
67,744,531 bp from pter
Size:
26,699 bases
Orientation:
Plus strand

Genomic View for NOL11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL11 Gene

Regulatory Elements for NOL11 Gene

Proteins for NOL11 Gene

  • Protein details for NOL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8H0-NOL11_HUMAN
    Recommended name:
    Nucleolar protein 11
    Protein Accession:
    Q9H8H0
    Secondary Accessions:
    • B7Z5V9
    • Q7L5S1
    • Q9UG18

    Protein attributes for NOL11 Gene

    Size:
    719 amino acids
    Molecular mass:
    81124 Da
    Quaternary structure:
    • Forms a complex with CIRH1A, UTP15, WDR43 and WDR75; within this complex, directly interacts with CIRH1A. Interacts with FBL/fibrillarin in a transcription-dependent manner.
    SequenceCaution:
    • Sequence=BAH13045.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAB53709.1; Type=Frameshift; Positions=382, 383; Evidence={ECO:0000305};

    Alternative splice isoforms for NOL11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL11 Gene

Proteomics data for NOL11 Gene at MOPED

Post-translational modifications for NOL11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys52, Lys125, Lys252, Lys344, Lys424, and Lys676

Other Protein References for NOL11 Gene

No data available for DME Specific Peptides for NOL11 Gene

Domains for NOL11 Gene

Protein Domains for NOL11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NOL11 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NOL11: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NOL11 Gene

Function for NOL11 Gene

Molecular function for NOL11 Gene

UniProtKB/Swiss-Prot Function: Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A, A0, 1 and 2b.

Gene Ontology (GO) - Molecular Function for NOL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22916032
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOL11: view

miRNA for NOL11 Gene

miRTarBase miRNAs that target NOL11

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NOL11 Gene

Localization for NOL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL11 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOL11 Gene COMPARTMENTS Subcellular localization image for NOL11 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NOL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IDA --
GO:0034455 t-UTP complex IDA 22916032
genes like me logo Genes that share ontologies with NOL11: view

Pathways for NOL11 Gene

SuperPathways for NOL11 Gene

No Data Available

Interacting Proteins for NOL11 Gene

Gene Ontology (GO) - Biological Process for NOL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030490 maturation of SSU-rRNA IMP 22916032
GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter IMP 22916032
genes like me logo Genes that share ontologies with NOL11: view

No data available for Pathways by source for NOL11 Gene

Transcripts for NOL11 Gene

Unigene Clusters for NOL11 Gene

Nucleolar protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOL11 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for NOL11 Gene

GeneLoc Exon Structure for
NOL11
ECgene alternative splicing isoforms for
NOL11

Expression for NOL11 Gene

mRNA expression in normal human tissues for NOL11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NOL11 Gene

SOURCE GeneReport for Unigene cluster for NOL11 Gene Hs.463936

genes like me logo Genes that share expressions with NOL11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOL11 Gene

Orthologs for NOL11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOL11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOL11 35
  • 99.63 (n)
  • 99.86 (a)
NOL11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOL11 35
  • 86.58 (n)
  • 84.4 (a)
NOL11 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOL11 35
  • 88.22 (n)
  • 85.2 (a)
NOL11 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nol11 35
  • 80.56 (n)
  • 77.44 (a)
Nol11 16
Nol11 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOL11 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOL11 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nol11 35
  • 78.38 (n)
  • 73.27 (a)
chicken
(Gallus gallus)
Aves LOC100859426 35
  • 64.63 (n)
  • 57.73 (a)
NOL11 36
  • 53 (a)
OneToMany
NOL11 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NOL11 36
  • 51 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15994 35
zebrafish
(Danio rerio)
Actinopterygii nol11 35
  • 52.55 (n)
  • 41.07 (a)
nol11 36
  • 38 (a)
OneToOne
Species with no ortholog for NOL11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOL11 Gene

ENSEMBL:
Gene Tree for NOL11 (if available)
TreeFam:
Gene Tree for NOL11 (if available)

Paralogs for NOL11 Gene

Pseudogenes.org Pseudogenes for NOL11 Gene

genes like me logo Genes that share paralogs with NOL11: view

No data available for Paralogs for NOL11 Gene

Variants for NOL11 Gene

Sequence variations from dbSNP and Humsavar for NOL11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs191128 -- 67,723,371(-) AAAAA(A/T)TTAGA intron-variant
rs917835 -- 67,726,187(-) GGACT(C/G)CCAAG intron-variant
rs960121 -- 67,717,680(-) AAGTG(C/T)TGCTT upstream-variant-2KB
rs999041 -- 67,722,818(-) GCTAC(A/G)AGGCA intron-variant
rs999042 -- 67,722,758(-) GCAGT(G/T)AACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOL11 Gene

Variant ID Type Subtype PubMed ID
nsv511059 CNV Complex 20534489
nsv510442 CNV Loss 20534489
esv2556372 CNV Deletion 19546169
esv2209241 CNV Deletion 18987734
esv3806 CNV Deletion 18987735
esv2716135 CNV Deletion 23290073
esv1406871 CNV Deletion 17803354
esv7392 CNV Loss 19470904

Relevant External Links for NOL11 Gene

HapMap Linkage Disequilibrium report
NOL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL11 Gene

Disorders for NOL11 Gene

No disorders were found for NOL11 Gene.

No data available for UniProtKB/Swiss-Prot for NOL11 Gene

Publications for NOL11 Gene

  1. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NOL11 Gene

Sources for NOL11 Gene

Back to Top

Content