NOL11 Gene
protein-coding GIFtS: 46
GCID: GC17P065714
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|
nucleolar protein 11
| |
Aliases
for NOL11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleolar Protein 111 2 | | DKFZP586L07241 |
Export aliases for NOL11 gene to outside databasesPrevious GC identifers: GC17P063145 GC17P061098 |
Summaries
for NOL11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NOL11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOL11 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 HFH-3 oct-B3 oct-B2 POU2F2 FOXI1 POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOL11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOL11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q24.2 Ensembl cytogenetic band: 17q24.2 HGNC cytogenetic band: 17q24.2NOL11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P065714: view genomic region
(about GC identifiers)
Start:
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65,713,949 bp from pter |
End:
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65,740,647 bp from pter |
Size:
|
26,699 bases |
Orientation:
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plus strand |
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Proteins
for NOL11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOL11_HUMAN, Q9H8H0 (See
protein sequence)Recommended Name: Nucleolar protein 11 Size: 719 amino acids; 81124 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=CAB53709.1; Type=Frameshift; Positions=382, 383;
Secondary accessions: Q7L5S1 Q9UG18Explore the universe of human proteins at neXtProt for NOL11: NX_Q9H8H0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H8H0
NOL11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056277.2
ENSEMBL proteins: ENSP00000253247 ENSP00000463662 ENSP00000463219 ENSP00000464015 ENSP00000463248 ENSP00000443765
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NOL11 for ontologies About GeneDecksing
NOL11 Antibody Products:
Assay Products for NOL11: |
Protein
Domains /
Families
for NOL11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOL11 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H8H0ProtoNet protein and cluster: Q9H8H0 1 Blocks protein family: IPB012584 NUC205
|
Function
for NOL11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NOL11 (NM_015462) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOL11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL11 |
|
Pathways & Interactions
for NOL11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOL11
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for NOL11 (Q9H8H02, 3 ENSP000002532474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for NOL11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NOL11
Search CenterWatch for drugs/clinical trials and news about NOL11
|
Transcripts
for NOL11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOL11 gene: NM_015462.3 Unigene Cluster for NOL11: Nucleolar protein 11 Hs.463936 [show with all ESTs]Unigene Representative Sequence: BC06440412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000253247(uc002jgd.1 uc010deu.1) ENST00000581106 ENST00000581966
ENST00000581375 ENST00000584942 ENST00000580833 ENST00000580914 ENST00000577687
ENST00000583108 ENST00000583021 ENST00000584032 ENST00000535137(uc010wql.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NOL11 (NM_015462) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOL11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL11 |
Additional cDNA sequence: AK023702.1 AK025390.1 AK299483.1 AL110271.1 AY598333.1 BC001726.2 BC064404.1 24 DOTS entries: DT.101974984 DT.452084 DT.100794540 DT.102831116 DT.100794537 DT.120898753 DT.40223506 DT.100794538 DT.91855481 DT.92445483 DT.100676957 DT.100677434 DT.100760116 DT.100794543 DT.120898555 DT.120898627 DT.120898665 DT.120898765 DT.121321366 DT.95107089 DT.95107129 DT.40130497 DT.75177525 DT.99956353 24/289 AceView cDNA sequences (see all 289): BU159266 AA765847 AA767810 N75228 AI500031 BE408084 BE251297 AA287974 AA291268 AI928962 BG283912 BQ711884 BM709920 AI701999 AL110271 CA429706 BM927977 BM693021 BQ020400 AA664580 AA426229 BM978454 BM468199 AA291339
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NOL11 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b |
|---|
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| SP1: | | | - | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NOL11
|
Expression
for NOL11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOL11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTTGAAT
About this image
See NOL11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOL11
SOURCE GeneReport for Unigene cluster: Hs.463936
SABiosciences Custom PCR Arrays for NOL11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOL11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOL11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOL11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOL11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL11 |
Orthologs
for NOL11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NOL11 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for NOL11 (if available)
TreeFam Gene Tree for NOL11 (if available) |
Paralogs
for NOL11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NOL11 gene
NOL11 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NOL11
PGOHUM00000242076
|
Genomic Variants
for NOL11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NOL11 (65713949 - 65740647 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for NOL11
1 CNV: 102513
5 Indels: 61580 45575 40195 25894 41767 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOL11 |
|
Disorders
/ Diseases
for NOL11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NOL11 for disorders About GeneDecksing
1  disease for NOL11: About MalaCardslung cancer
Export disorders for NOL11 gene to outside databases
|
Publications
for NOL11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOL11 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with NOL11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- NOL11, implicated in the pathogenesis of North America n Indian childhood cirrhosis, is required for pre-rRNA transcription and process ing. (PubMed id 22916032)1 Freed E.F....Baserga S.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for NOL11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NOL11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOL11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOL11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOL11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NOL11 gene:
Search GeneIP for patents involving NOL11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOL11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NOL11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOL11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOL11 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NOL11 | | OriGene 3'-UTR Clone for NOL11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NOL11 | | OriGene Custom Protein Services for NOL11 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOL11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOL11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOL11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOL11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOL11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOL11 |
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| | | | Search Tocris compounds for NOL11 |
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 | | | NOL11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL11 |
|  |  |  | | | | ThermoFisher Antibodies for NOL11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL11 |
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