NOL10 Gene
protein-coding GIFtS: 44
GCID: GC02M010662
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|
nucleolar protein 10(Previous name: polyglutamine binding protein 5 )
(Previous symbol: PQBP5)
| |
Aliases
for NOL10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleolar Protein 101 2 | | PQBP51 2 | | Polyglutamine Binding Protein 51 2 | | FLJ140751 | | H_NH0074G24.12 |
Export aliases for NOL10 gene to outside databases |
Summaries
for NOL10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NOL10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005334.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOL10 gene promoter:
Bach2 p300 YY1 Evi-1 E47 CREB POU2F1 POU2F1a deltaCREB Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOL10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOL10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p25.1 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25.1NOL10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M010662: view genomic region
(about GC identifiers)
Start:
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10,710,892 bp from pter |
End:
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10,830,112 bp from pter |
Size:
|
119,221 bases |
Orientation:
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minus strand |
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Proteins
for NOL10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOL10_HUMAN, Q9BSC4 (See
protein sequence)Recommended Name: Nucleolar protein 10 Size: 688 amino acids; 80302 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: A8K3R5 B4DLV0 Q53RC9 Q96TA5 Q9H7Y7 Q9H855Alternative splicing: 4 isoforms: Q9BSC4-1 Q9BSC4-2 Q9BSC4-3 Q9BSC4-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NOL10: NX_Q9BSC4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BSC4
NOL10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001248321.1 NP_001248323.1 NP_079170.2
ENSEMBL proteins: ENSP00000263837 ENSP00000371101 ENSP00000403170 ENSP00000439663 ENSP00000437625
Human Recombinant Protein Products for NOL10:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NOL10 for ontologies About GeneDecksing
NOL10 Antibody Products:
Assay Products for NOL10: |
Protein
Domains /
Families
for NOL10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOL10 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BSC4ProtoNet protein and cluster: Q9BSC4 1 Blocks protein family: IPB012580 NUC153
UniProtKB/Swiss-Prot: NOL10_HUMAN, Q9BSC4Similarity: Belongs to the WD repeat NOL10/ENP2 familySimilarity: Contains 5 WD repeats |
Function
for NOL10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for NOL10:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL10 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL10 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NOL10 (NM_024894) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOL10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL10 |
|
Pathways & Interactions
for NOL10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOL10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/135 Interacting proteins for NOL10 (Q9BSC42, 3 ENSP000003711014) via UniProtKB, MINT, STRING, and/or I2D (see all 135)About this table
|
Drugs & Compounds
for NOL10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NOL10
Search CenterWatch for drugs/clinical trials and news about NOL10
|
Transcripts
for NOL10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOL10 gene (3 alternative transcripts): NM_001261392.1 NM_001261394.1 NM_024894.3 Unigene Cluster for NOL10: Nucleolar protein 10 Hs.222494 [show with all ESTs]Unigene Representative Sequence: NM_0248946 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000345985(uc002raq.2 uc010yje.1 uc010yjf.1 uc002rap.2)
ENST00000381685(uc002rar.2) ENST00000431319 ENST00000473087 ENST00000538384
ENST00000542668
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL10 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL10 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NOL10 (NM_024894) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOL10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL10 |
Additional cDNA sequence: AK024000.1 AK024137.1 AK290680.1 AK297169.1 AK299617.1 BC005125.2 BC037841.1 NR_048552.1 12 DOTS entries: DT.97813752 DT.92441458 DT.91822604 DT.95114058 DT.455034 DT.92441454 DT.100784258 DT.100736820 DT.120941254 DT.120941258 DT.40307494 DT.92023437 24/194 AceView cDNA sequences (see all 194): BC005125 CB129943 BU839517 BQ015358 BX380050 BX952911 CK904285 BM021448 BU189248 AA314293 BM450563 BQ919963 AU121018 BU189850 CR614196 BQ672892 AU280228 AK024000 AU142750 CB119807 BI870772 CR612766 AA320880 BM701450
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NOL10 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b |
|---|
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| SP1: | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NOL10
|
Expression
for NOL10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOL10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NOL10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOL10
SOURCE GeneReport for Unigene cluster: Hs.222494
SABiosciences Custom PCR Arrays for NOL10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOL10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOL10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOL10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOL10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL10 |
Orthologs
for NOL10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NOL10 gene from 10/34 species (see all 34) About this table
ENSEMBL Gene Tree for NOL10 (if available)
TreeFam Gene Tree for NOL10 (if available) |
Paralogs
for NOL10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NOL10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NOL10 (10710892 - 10830112 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NOL10: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOL10 |
|
Disorders
/ Diseases
for NOL10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NOL10 for disorders About GeneDecksing
1  disease for NOL10: About MalaCardsmalaria
Export disorders for NOL10 gene to outside databases
|
Publications
for NOL10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOL10 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with NOL10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for NOL10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NOL10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOL10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOL10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOL10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NOL10 gene:
Search GeneIP for patents involving NOL10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOL10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NOL10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOL10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOL10 | | | OriGene Protein Over-expression Lysate for NOL10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NOL10 | | OriGene 3'-UTR Clone for NOL10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOL10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOL10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NOL10 | | OriGene Custom Protein Services for NOL10 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOL10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOL10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOL10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOL10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOL10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOL10 |
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| | | | Search Tocris compounds for NOL10 |
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 | | | NOL10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOL10 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for NOL10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOL10 |
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