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Aliases for NOL10 Gene

Aliases for NOL10 Gene

  • Nucleolar Protein 10 2 3 5
  • Polyglutamine Binding Protein 5 2 3
  • H_NH0074G24.1 3
  • PQBP5 3

External Ids for NOL10 Gene

Previous HGNC Symbols for NOL10 Gene

  • PQBP5

Summaries for NOL10 Gene

GeneCards Summary for NOL10 Gene

NOL10 (Nucleolar Protein 10) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Additional gene information for NOL10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL10 Gene

Genomics for NOL10 Gene

Regulatory Elements for NOL10 Gene

Enhancers for NOL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H010583 1.3 Ensembl ENCODE dbSUPER 41.4 +104.9 104894 2 SOX13 FOXA2 GATA3 RERE FOS NR2F6 CREM MAFK RFX1 HMG20B NOL10 ENSG00000234818 LOC105373426
GH02H010574 0.9 ENCODE dbSUPER 51.6 +113.8 113837 2 ZNF639 SP3 ZNF362 JUN ZNF140 FEZF1 TSHZ1 EP300 FOSL1 JUND NOL10 RN7SL832P TAF1B LOC101929882 ENSG00000234818 LOC105373426
GH02H010429 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +257.1 257127 5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YBX1 FEZF1 ZBTB7B ZNF207 TAF1B LOC101929882 KLF11 NOL10 C2orf48 YWHAQ ENSG00000217258 ENSG00000239300 ENSG00000233502 CYS1
GH02H009842 1.4 ENCODE dbSUPER 24.3 +846.0 845997 2 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZBTB7B SLC30A9 ZNF766 TAF1B NOL10 CPSF3 LOC101929882 ENSG00000269973 ENSG00000239300
GH02H009829 1.4 Ensembl ENCODE dbSUPER 24.1 +858.6 858611 2 HDAC1 TBP PKNOX1 NFIB ARNT ZBTB40 GTF3C2 ZNF766 GATA2 ELK1 CPSF3 NOL10 ENSG00000269973 LOC101929882 ENSG00000239300 TAF1B LOC105373421
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOL10 on UCSC Golden Path with GeneCards custom track

Promoters for NOL10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000112814 -13 2000 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for NOL10 Gene

10,570,766 bp from pter
10,689,987 bp from pter
119,222 bases
Minus strand

Genomic View for NOL10 Gene

Genes around NOL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL10 Gene

Proteins for NOL10 Gene

  • Protein details for NOL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 10
    Protein Accession:
    Secondary Accessions:
    • A8K3R5
    • B4DLV0
    • Q53RC9
    • Q96TA5
    • Q9H7Y7
    • Q9H855

    Protein attributes for NOL10 Gene

    688 amino acids
    Molecular mass:
    80302 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NOL10 Gene


neXtProt entry for NOL10 Gene

Post-translational modifications for NOL10 Gene

  • Ubiquitination at Lys74
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NOL10 Gene

Domains & Families for NOL10 Gene

Gene Families for NOL10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NOL10 Gene

Suggested Antigen Peptide Sequences for NOL10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat NOL10/ENP2 family.
  • Belongs to the WD repeat NOL10/ENP2 family.
genes like me logo Genes that share domains with NOL10: view

Function for NOL10 Gene

Phenotypes From GWAS Catalog for NOL10 Gene

Gene Ontology (GO) - Molecular Function for NOL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOL10: view
genes like me logo Genes that share phenotypes with NOL10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NOL10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL10 Gene

Localization for NOL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL10 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOL10 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NOL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA,IEA --
genes like me logo Genes that share ontologies with NOL10: view

Pathways & Interactions for NOL10 Gene

SuperPathways for NOL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL10 Gene


No data available for Pathways by source and SIGNOR curated interactions for NOL10 Gene

Drugs & Compounds for NOL10 Gene

No Compound Related Data Available

Transcripts for NOL10 Gene

Unigene Clusters for NOL10 Gene

Nucleolar protein 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NOL10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NOL10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: - - -
SP2: - - - -
SP3: - - -
SP5: - -

Relevant External Links for NOL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NOL10 Gene

Protein differential expression in normal tissues from HIPED for NOL10 Gene

This gene is overexpressed in Colon muscle (25.0), Peripheral blood mononuclear cells (10.7), Blymphocyte (9.9), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL10 Gene

Protein tissue co-expression partners for NOL10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOL10 Gene:


SOURCE GeneReport for Unigene cluster for NOL10 Gene:


Evidence on tissue expression from TISSUES for NOL10 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with NOL10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOL10 Gene

Orthologs for NOL10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOL10 33 34
  • 99.81 (n)
(Canis familiaris)
Mammalia NOL10 33 34
  • 92.34 (n)
(Monodelphis domestica)
Mammalia NOL10 34
  • 91 (a)
(Bos Taurus)
Mammalia NOL10 33 34
  • 90.12 (n)
(Rattus norvegicus)
Mammalia Nol10 33
  • 88.91 (n)
(Mus musculus)
Mammalia Nol10 33 16 34
  • 88.5 (n)
(Ornithorhynchus anatinus)
Mammalia NOL10 34
  • 79 (a)
(Gallus gallus)
Aves NOL10 33 34
  • 78.83 (n)
(Anolis carolinensis)
Reptilia NOL10 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nol10 33
  • 73.62 (n)
Str.1457 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69094 33
(Danio rerio)
Actinopterygii nol10 33 34
  • 66.18 (n)
zgc55626 33
fruit fly
(Drosophila melanogaster)
Insecta l(2)34Fd 33 34
  • 54.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008159 33
  • 24.42 (n)
(Caenorhabditis elegans)
Secernentea nol-10 33 34
  • 51.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENP2 33 34
  • 54.68 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04653g 33
  • 51.34 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR468W 33
  • 48.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons EDA7 33
  • 53.9 (n)
(Oryza sativa)
Liliopsida Os06g0128400 33
  • 52.83 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC330.09 33
  • 57.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03961 33
  • 49.31 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8724 33
Species where no ortholog for NOL10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOL10 Gene

Gene Tree for NOL10 (if available)
Gene Tree for NOL10 (if available)

Paralogs for NOL10 Gene

No data available for Paralogs for NOL10 Gene

Variants for NOL10 Gene

Sequence variations from dbSNP and Humsavar for NOL10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000004395 -- 10,597,625(+) TTTCA(A/G)AAGAC intron-variant
rs1000005088 -- 10,635,902(+) TCTTA(C/T)TTTTT intron-variant
rs1000062597 -- 10,586,802(+) TCCAG(-/CTTAT)CTTAT intron-variant
rs1000081486 -- 10,611,656(+) CACAC(C/T)TGTAA intron-variant
rs1000115025 -- 10,666,415(+) AATCT(G/T)CATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOL10 Gene

Variant ID Type Subtype PubMed ID
esv2866236 CNV insertion 24192839
esv3589805 CNV loss 21293372
nsv1000731 CNV gain 25217958
nsv1007185 CNV gain 25217958
nsv1131449 CNV deletion 24896259
nsv1160568 CNV deletion 26073780
nsv472965 CNV novel sequence insertion 20440878
nsv828341 CNV loss 20364138
nsv828352 CNV gain 20364138
nsv833370 CNV gain 17160897
nsv833381 CNV loss 17160897

Variation tolerance for NOL10 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL10 Gene

Disorders for NOL10 Gene

Relevant External Links for NOL10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL10 Gene

Publications for NOL10 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for NOL10 Gene

Sources for NOL10 Gene

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