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Aliases for NOL10 Gene

Aliases for NOL10 Gene

  • Nucleolar Protein 10 2 3 5
  • Polyglutamine Binding Protein 5 2 3
  • H_NH0074G24.1 3
  • PQBP5 3

External Ids for NOL10 Gene

Previous HGNC Symbols for NOL10 Gene

  • PQBP5

Summaries for NOL10 Gene

GeneCards Summary for NOL10 Gene

NOL10 (Nucleolar Protein 10) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL10 Gene

Genomics for NOL10 Gene

Regulatory Elements for NOL10 Gene

Enhancers for NOL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NOL10 on UCSC Golden Path with GeneCards custom track

Promoters for NOL10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NOL10 Gene

10,570,766 bp from pter
10,689,987 bp from pter
119,222 bases
Minus strand

Genomic View for NOL10 Gene

Genes around NOL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL10 Gene

Proteins for NOL10 Gene

  • Protein details for NOL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar protein 10
    Protein Accession:
    Secondary Accessions:
    • A8K3R5
    • B4DLV0
    • Q53RC9
    • Q96TA5
    • Q9H7Y7
    • Q9H855

    Protein attributes for NOL10 Gene

    688 amino acids
    Molecular mass:
    80302 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NOL10 Gene


neXtProt entry for NOL10 Gene

Post-translational modifications for NOL10 Gene

  • Ubiquitination at Lys 74
  • Modification sites at PhosphoSitePlus

Other Protein References for NOL10 Gene

No data available for DME Specific Peptides for NOL10 Gene

Domains & Families for NOL10 Gene

Protein Domains for NOL10 Gene

Suggested Antigen Peptide Sequences for NOL10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat NOL10/ENP2 family.
  • Contains 7 WD repeats.
  • Belongs to the WD repeat NOL10/ENP2 family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with NOL10: view

No data available for Gene Families for NOL10 Gene

Function for NOL10 Gene

Gene Ontology (GO) - Molecular Function for NOL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOL10: view
genes like me logo Genes that share phenotypes with NOL10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL10 Gene

Localization for NOL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL10 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for NOL10 Gene COMPARTMENTS Subcellular localization image for NOL10 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NOL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with NOL10: view

Pathways & Interactions for NOL10 Gene

SuperPathways for NOL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL10 Gene


No data available for Pathways by source and SIGNOR curated interactions for NOL10 Gene

Drugs & Compounds for NOL10 Gene

No Compound Related Data Available

Transcripts for NOL10 Gene

Unigene Clusters for NOL10 Gene

Nucleolar protein 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOL10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: - - -
SP2: - - - -
SP3: - - -
SP5: - -

Relevant External Links for NOL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOL10 Gene

mRNA expression in normal human tissues for NOL10 Gene

Protein differential expression in normal tissues from HIPED for NOL10 Gene

This gene is overexpressed in Colon muscle (25.0), Peripheral blood mononuclear cells (10.7), Blymphocyte (9.9), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOL10 Gene

Protein tissue co-expression partners for NOL10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOL10 Gene:


SOURCE GeneReport for Unigene cluster for NOL10 Gene:

genes like me logo Genes that share expression patterns with NOL10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOL10 Gene

Orthologs for NOL10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOL10 34
  • 90.12 (n)
  • 96.51 (a)
NOL10 35
  • 96 (a)
(Canis familiaris)
Mammalia NOL10 34
  • 92.34 (n)
  • 97.38 (a)
NOL10 35
  • 97 (a)
(Mus musculus)
Mammalia Nol10 34
  • 88.5 (n)
  • 95.05 (a)
Nol10 16
Nol10 35
  • 96 (a)
(Pan troglodytes)
Mammalia NOL10 34
  • 99.81 (n)
  • 100 (a)
NOL10 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Nol10 34
  • 88.91 (n)
  • 95.49 (a)
(Monodelphis domestica)
Mammalia NOL10 35
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia NOL10 35
  • 79 (a)
(Gallus gallus)
Aves NOL10 34
  • 78.83 (n)
  • 84.88 (a)
NOL10 35
  • 85 (a)
(Anolis carolinensis)
Reptilia NOL10 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nol10 34
  • 73.62 (n)
  • 80.61 (a)
Str.1457 34
African clawed frog
(Xenopus laevis)
Amphibia MGC69094 34
(Danio rerio)
Actinopterygii nol10 34
  • 66.18 (n)
  • 73.9 (a)
zgc55626 34
nol10 35
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008159 34
  • 24.42 (n)
  • 4.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)34Fd 34
  • 54.17 (n)
  • 52.82 (a)
l(2)34Fd 35
  • 43 (a)
(Caenorhabditis elegans)
Secernentea nol-10 34
  • 51.87 (n)
  • 45.73 (a)
nol-10 35
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR468W 34
  • 48.25 (n)
  • 41.55 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04653g 34
  • 51.34 (n)
  • 43.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENP2 34
  • 54.68 (n)
  • 49.01 (a)
ENP2 35
  • 39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EDA7 34
  • 53.9 (n)
  • 44.64 (a)
(Oryza sativa)
Liliopsida Os06g0128400 34
  • 52.83 (n)
  • 44.23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8724 34
bread mold
(Neurospora crassa)
Ascomycetes NCU03961 34
  • 49.31 (n)
  • 44.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC330.09 34
  • 57.27 (n)
  • 52.6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
Species where no ortholog for NOL10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOL10 Gene

Gene Tree for NOL10 (if available)
Gene Tree for NOL10 (if available)

Paralogs for NOL10 Gene

No data available for Paralogs for NOL10 Gene

Variants for NOL10 Gene

Sequence variations from dbSNP and Humsavar for NOL10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2287059 - 10,577,680(+) GGTGT(C/T)GGATA nc-transcript-variant, reference, missense
rs1023587 -- 10,656,050(+) CCACA(C/T)GATGG intron-variant
rs1023588 -- 10,656,055(+) TGATG(A/G)AAACT intron-variant
rs1038690 -- 10,673,118(-) GTTGT(A/G)TGTTT intron-variant
rs1045596 -- 10,571,861(-) GGTGT(A/G)CTTGC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NOL10 Gene

Variant ID Type Subtype PubMed ID
esv2866236 CNV insertion 24192839
esv3589805 CNV loss 21293372
nsv1000731 CNV gain 25217958
nsv1007185 CNV gain 25217958
nsv1131449 CNV deletion 24896259
nsv1160568 CNV deletion 26073780
nsv472965 CNV novel sequence insertion 20440878
nsv828341 CNV loss 20364138
nsv828352 CNV gain 20364138
nsv833370 CNV gain 17160897
nsv833381 CNV loss 17160897

Variation tolerance for NOL10 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL10 Gene

Disorders for NOL10 Gene

Relevant External Links for NOL10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL10 Gene

Publications for NOL10 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 65

Products for NOL10 Gene

Sources for NOL10 Gene

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