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Aliases for NOL10 Gene

Aliases for NOL10 Gene

  • Nucleolar Protein 10 2 3 5
  • Polyglutamine Binding Protein 5 2 3
  • H_NH0074G24.1 3
  • PQBP5 3

External Ids for NOL10 Gene

Previous HGNC Symbols for NOL10 Gene

  • PQBP5

Summaries for NOL10 Gene

GeneCards Summary for NOL10 Gene

NOL10 (Nucleolar Protein 10) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOL10 Gene

Genomics for NOL10 Gene

Regulatory Elements for NOL10 Gene

Promoters for NOL10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOL10 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOL10 Gene

Chromosome:
2
Start:
10,570,766 bp from pter
End:
10,689,987 bp from pter
Size:
119,222 bases
Orientation:
Minus strand

Genomic View for NOL10 Gene

Genes around NOL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOL10 Gene

Proteins for NOL10 Gene

  • Protein details for NOL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSC4-NOL10_HUMAN
    Recommended name:
    Nucleolar protein 10
    Protein Accession:
    Q9BSC4
    Secondary Accessions:
    • A8K3R5
    • B4DLV0
    • Q53RC9
    • Q96TA5
    • Q9H7Y7
    • Q9H855

    Protein attributes for NOL10 Gene

    Size:
    688 amino acids
    Molecular mass:
    80302 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NOL10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOL10 Gene

Proteomics data for NOL10 Gene at MOPED

Post-translational modifications for NOL10 Gene

  • Ubiquitination at Lys 74
  • Modification sites at PhosphoSitePlus

Other Protein References for NOL10 Gene

No data available for DME Specific Peptides for NOL10 Gene

Domains & Families for NOL10 Gene

Protein Domains for NOL10 Gene

Suggested Antigen Peptide Sequences for NOL10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BSC4

UniProtKB/Swiss-Prot:

NOL10_HUMAN :
  • Belongs to the WD repeat NOL10/ENP2 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat NOL10/ENP2 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with NOL10: view

No data available for Gene Families for NOL10 Gene

Function for NOL10 Gene

genes like me logo Genes that share phenotypes with NOL10: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOL10 Gene

Localization for NOL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOL10 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOL10 Gene COMPARTMENTS Subcellular localization image for NOL10 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for NOL10 Gene

Pathways & Interactions for NOL10 Gene

SuperPathways for NOL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOL10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NOL10 Gene

Drugs & Compounds for NOL10 Gene

No Compound Related Data Available

Transcripts for NOL10 Gene

Unigene Clusters for NOL10 Gene

Nucleolar protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOL10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: - -

Relevant External Links for NOL10 Gene

GeneLoc Exon Structure for
NOL10
ECgene alternative splicing isoforms for
NOL10

Expression for NOL10 Gene

mRNA expression in normal human tissues for NOL10 Gene

Protein differential expression in normal tissues from HIPED for NOL10 Gene

This gene is overexpressed in Colon muscle (25.0), Peripheral blood mononuclear cells (10.7), Blymphocyte (9.9), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOL10 Gene



SOURCE GeneReport for Unigene cluster for NOL10 Gene Hs.222494

genes like me logo Genes that share expression patterns with NOL10: view

Protein tissue co-expression partners for NOL10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOL10 Gene

Orthologs for NOL10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOL10 36
  • 100 (a)
OneToOne
NOL10 35
  • 99.81 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia NOL10 36
  • 96 (a)
OneToOne
NOL10 35
  • 90.12 (n)
  • 96.51 (a)
dog
(Canis familiaris)
Mammalia NOL10 35
  • 92.34 (n)
  • 97.38 (a)
NOL10 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nol10 36
  • 96 (a)
OneToOne
Nol10 35
  • 88.5 (n)
  • 95.05 (a)
Nol10 16
oppossum
(Monodelphis domestica)
Mammalia NOL10 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOL10 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nol10 35
  • 88.91 (n)
  • 95.49 (a)
chicken
(Gallus gallus)
Aves NOL10 35
  • 78.83 (n)
  • 84.88 (a)
NOL10 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOL10 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69094 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nol10 35
  • 73.62 (n)
  • 80.61 (a)
Str.1457 35
zebrafish
(Danio rerio)
Actinopterygii nol10 35
  • 66.18 (n)
  • 73.9 (a)
zgc55626 35
nol10 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008159 35
  • 24.42 (n)
  • 4.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)34Fd 35
  • 54.17 (n)
  • 52.82 (a)
l(2)34Fd 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nol-10 36
  • 39 (a)
OneToOne
nol-10 35
  • 51.87 (n)
  • 45.73 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR468W 35
  • 48.25 (n)
  • 41.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENP2 35
  • 54.68 (n)
  • 49.01 (a)
ENP2 36
  • 39 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04653g 35
  • 51.34 (n)
  • 43.31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EDA7 35
  • 53.9 (n)
  • 44.64 (a)
rice
(Oryza sativa)
Liliopsida Os06g0128400 35
  • 52.83 (n)
  • 44.23 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03961 35
  • 49.31 (n)
  • 44.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC330.09 35
  • 57.27 (n)
  • 52.6 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8724 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for NOL10:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOL10 Gene

ENSEMBL:
Gene Tree for NOL10 (if available)
TreeFam:
Gene Tree for NOL10 (if available)

Paralogs for NOL10 Gene

No data available for Paralogs for NOL10 Gene

Variants for NOL10 Gene

Sequence variations from dbSNP and Humsavar for NOL10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2287059 - 10,577,680(+) GGTGT(C/T)GGATA nc-transcript-variant, reference, missense
rs759402 -- 10,589,428(+) TTTAA(A/T)TAAAT intron-variant
rs759403 -- 10,589,771(+) AAGTA(C/T)GTAAA intron-variant
rs744809 -- 10,649,123(-) CAGGG(C/T)GGCAT intron-variant
rs715247 -- 10,596,165(+) TCCTA(A/G)CCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOL10 Gene

Variant ID Type Subtype PubMed ID
nsv833370 CNV Gain 17160897
nsv828341 CNV Loss 20364138
nsv833381 CNV Loss 17160897
nsv828352 CNV Gain 20364138

Variation tolerance for NOL10 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOL10 Gene

HapMap Linkage Disequilibrium report
NOL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOL10 Gene

Disorders for NOL10 Gene

Relevant External Links for NOL10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOL10

No disorders were found for NOL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOL10 Gene

Publications for NOL10 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for NOL10 Gene

Sources for NOL10 Gene

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