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NOG Gene

protein-coding GIFtS: 62

GC17P052026

noggin
(Previous names: synostoses (multiple) syndrome 1, symphalangism 1 (proximal) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: SYNS1, SYM1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
SYM1 ^², ⁵
SYNS1 ^², ⁵
noggin ^²

Descriptions
symphalangism 1 (proximal) ^¹, ²
synostoses (multiple) syndrome 1 ^¹

External Ids
HGNC: 7866¹
Entrez Gene: 9241²
UniProtKB: Q13253³
Ensembl: ENSG00000183691⁷

Search outside databases for aliases for NOG gene

Previous GC identifers: GC17P054405 GC17P057152 GC17P055013 GC17P055146 GC17P055147

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NOG:

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming

growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4

(BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta

superfamily, this protein may have a principal role in creating morphogenic gradients. The protein

appears to have pleiotropic effect, both early in development as well as in later stages. It was

originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis

in embryos that had been artificially ventralized by UV treatment. The results of the mouse

knockout of the ortholog suggest that it is involved in numerous developmental processes, such as

neural tube fusion and joint formation. Recently, several dominant human NOG mutations in

unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1)

were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and

map to the same region (17q22) as this gene. All of these mutations altered evolutionarily

conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to

that of Xenopus, rat and mouse. [provided by RefSeq]

UniProtKB/Swiss-Prot: NOGG_HUMAN, Q13253

Function: Essential for cartilage morphogenesis and joint formation. Inhibitor of bone

morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural

tube and somite (By similarity)

Gene Wiki entry for NOG (Noggin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NOG gene

Entrez Gene cytogenetic band: 17q21-q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q22

NOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P052026: (about GC identifiers)

Start:	52,026,274 bp from pter
End:	52,027,546 bp from pter
Size:	1,273 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NOGG_HUMAN, Q13253 (See protein sequence)

Recommended Name: Noggin precursor

Size: 232 amino acids; 25774 Da

Subunit: Homodimer; disulfide-linked (By similarity)

Subcellular location: Secreted

PDB structures from and Proteopedia :

1M4U (3D)

REFSEQ proteins: NP_005441.1

ENSEMBL proteins:

ENSP00000328181

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for NOG (Noggin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Noggin)
	Human Recombinant Proteins from Abnova (NOG)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	10080184

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Antibodies for NOG:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of NOG
	Sigma-Aldrich Antibodies for NOG
	R&D Systems Antibodies for NOG (Noggin)
	Antibodies from Abcam (Noggin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NOG)
	Novus Biologicals Antibodies for NOG

Assays for NOG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13253

ProtoNet protein and cluster: Q13253

1 Blocks protein family: IPB008717 Noggin

UniProtKB/Swiss-Prot: NOGG_HUMAN, Q13253

Similarity: Belongs to the noggin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NOG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NOG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005450

Applied Biosystems Silencer® siRNAs for NOG

Sigma-Aldrich siRNA and siRNA Panels for NOG

Sigma-Aldrich shRNA for NOG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NOG
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005450
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005450
untagged cDNA clone in CMV expression vector: NM_005450

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005450

UniProtKB/Swiss-Prot: NOGG_HUMAN, Q13253

Function: Essential for cartilage morphogenesis and joint formation. Inhibitor of bone

morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural

tube and somite (By similarity)

Genatlas biochemistry entry for NOG:

noggin,Spemann organizer,binding and inactivating BMP4 and other TGFB family members,involved in

the joint formation and in skeletogenesis

15/21 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nog) (see all 21 ):

	cellular	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	homeostasis/metabolism	lethality-prenatal/perinatal
limbs/digits/tail	muscle	nervous system	normal	renal/urinary system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019955	cytokine binding	IPI	8752214
GO:0042803	protein homodimerization activity	IDA	11562478

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for NOG (Your Favorite Gene powered by Ingenuity)

Factors Promoting Cardiogenesis in Vertebrates
BMP signaling pathway
Human Embryonic Stem Cell Pluripotency

GeneDecks NOG for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for NOG

5/88 Interacting proteins for NOG (Q13253¹ ENSP00000328181³) via UniProtKB, MINT, and/or STRING (see all 88 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMP7	P18075¹, ENSP00000360340³	EBI-1035205, EBI-1035195 STRING (score=.999)
BMP2	ENSP00000368104³	STRING (score=.999)
BMP4	ENSP00000245451³	STRING (score=.999)
GDF5	ENSP00000363489³	STRING (score=.998)
BMPR1A	ENSP00000361107³	STRING (score=.996)

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5/24 Gene Ontology (GO) biological process terms (links to tree view) (see all 24 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001649	osteoblast differentiation	IEA	--
GO:0001657	ureteric bud development	IEA	--
GO:0001837	epithelial to mesenchymal transition	IEA	--
GO:0007389	pattern specification process	IEA	--
GO:0007420	brain development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NOG
7 Novoseek chemical compound relationships for NOG gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclopamine	51.00	1	14584895 (1)
cystine	25.67	5	12925610 (2), 14525956 (1), 15621726 (1), 12478285 (1)
heparan sulfate	8.48	7	14645250 (2), 11706034 (1), 18515207 (1)
lithium	0.00	2	9188756 (1), 16804895 (1)
calcium	0.00	1	12239209 (1)
tyrosine	0.00	1	18945349 (1)
ribonucleic acid	0.00	1	10969730 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NOG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NOG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005450

Sigma-Aldrich siRNA and siRNA Panels for NOG

Sigma-Aldrich shRNA for NOG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005450

REFSEQ mRNAs for NOG gene:

NM_005450.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005450

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005450
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005450
                                 untagged cDNA clone in CMV expression vector: NM_005450

Additional cDNA sequence:

AK314080.1 BC034027.1 CR611456.1

1 DOTS entry:

DT.75174211

12 AceView cDNA sequences:

NM_005450 AI634984 BX283192 CR611456 AW295785 BQ710008 BC034027 AA045124

AW205295 AL551507 BG610858 AL575177

highest scoring ESTs for NOG:

BC034027 BX283192 AI634984 AL551507 AW205295 AW295785 BG610858 BQ710008 CR611456 NM_005450

Unigene Cluster for NOG:

Noggin

Hs.248201 [show with all ESTs]

Unigene Representative Sequence: NM_005450

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000332822

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NOG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NOG

¹ / ² / ³

2 probe-sets matching NOG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
231798_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL575177	0.40	1.00	0.76	1
231798_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCGAAGCAGG

SOURCE GeneReport for Unigene cluster: Hs.248201

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NOG gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	NOG¹	--	noggin	99.14(n) 99.57(a)	468413 XM_523802.2 XP_523802.2
cow (Bos taurus)	NOG¹	--	noggin	95.98(n) 97.84(a)	538769 XM_582573.3 XP_582573.3
rat (Rattus norvegicus)	Nog¹	--	noggin	93.68(n) 99.14(a)	25495 XM_343954.3 XP_343955.3
mouse (Mus musculus)	Nog^{1, 5}	11 (50.50 cM)⁵	noggin^{1, 5}	93.82(n)¹ 99.14(a)¹	18121¹ NM_008711.1¹ NP_032737.1¹ AK146488⁵ AL672175⁵ (see all 9)
chicken (Gallus gallus)	NOG¹	--	noggin	79.48(n) 85.65(a)	373912 NM_204123.1 NP_989454.1

About this table Species with no ortholog for NOG

ENSEMBL Gene Tree for NOG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/13 NCBI SNPs in NOG are shown (see all 13 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 30)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1348322^1,2	H	52027585(-)	`TCTTTT/GGCTTA`	1	--	ut3¹		4		EU EA WA	418
--	rs1236187^1,2	C	52027392(-)	`aaaaaA/GGTTCA`	1	--	ut3¹ trp³		0	--	--	--	--
--	rs71888945^1,2	--	52027403(+)	`TTTTT-/TTTTT TTTTT`	1	--	ut3¹		0	--	--	--	--
--	rs34644995^1,2	--	52025310(+)	`TGTGT-/GTATATA`	1	--	ng5¹		0	--	--	--	--
--	rs71671792^1,2	--	52027407(+)	`TTTTT-/TTTTTT TTTTT`	1	--	ut3¹		0	--	--	--	--
--	rs28937580^1,2	--	52026686(+)	`TCCGCC/TCGGCA`	1	P/S	mis¹ ese³		0	--	--	--	--
--	rs67555616^1,2	--	52027403(+)	`TTTTT-/TTTTTT TTTTT`	1	--	ut3¹		0	--	--	--	--
--	rs62074818^1,2	--	52024738(+)	`CACCCA/GCTGAG`	1	--	ng5¹		0	--	--	--	--
--	rs73993426^1,2	--	52025310(+)	`TGTGTA/GTATAT`	1	--	ng5¹		0	--	--	--	--
--	rs71139919^1,2	--	52027416(+)	`TTTTT-/TTCTGGG`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for NOG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602991 disorders: 185800 186500 186570 184460 611377

UniProtKB/Swiss-Prot: NOGG_HUMAN, Q13253

Defects in NOG are a cause of symphalangism proximal syndrome (SYM1) [MIM:185800]. SYM1 is

characterized by the hereditary absence of the proximal interphalangeal (PIP) joints (Cushing

symphalangism). Severity of PIP joint involvement diminishes towards the radial side. Distal

interphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely

affected whereas carpal bone malformation and fusion are common. In the lower extremities, tarsal

bone coalition is common. Conducive hearing loss is seen and is due to fusion of the stapes to the

petrous part of the temporal bone

Defects in NOG are the cause of multiple synostoses syndrome 1 (SYNS1) [MIM:186500]; also

known as synostoses, multiple, with brachydactyly/symphalangism-brachydactyly syndrome. SYNS1 is

characterized by tubular-shaped (hemicylindrical) nose with lack of alar flare, otosclerotic

deafness, and multiple progressive joint fusions commencing in the hand. The joint fusions are

progressive, commencing in the fifth proximal interphalangeal joint in early childhood (or at

birth in some individuals) and progressing in an ulnar-to-radial and proximal-to-distal direction.

With increasing age, ankylosis of other joints, including the cervical vertebrae, hips, and

humeroradial joints, develop

Defects in NOG are the cause of tarsal-carpal coalition syndrome (TCC) [MIM:186570]. TCC

is an autosomal dominant disorder characterized by fusion of the carpals, tarsals and phalanges,

short first metacarpals causing brachydactyly, and humeroradial fusion. TCC is allelic to SYM1,

and different mutations in NOG can result in either TCC or SYM1 in different families

Defects in NOG are a cause of stapes ankylosis with broad thumb and toes [MIM:184460].

Stapes ankylosis with broad thumb and toes is a congenital autosomal dominant disorder that

includes hyperopia, a hemicylindrical nose, broad thumbs, great toes, and other minor skeletal

anomalies but lacked carpal and tarsal fusion and symphalangism

Defects in NOG are the cause of brachydactyly type B2 (BDB2) [MIM:611377]. BDB2 is a

subtype of brachydactyly characterized by hypoplasia/aplasia of distal phalanges in combination

with distal symphalangism, fusion of carpal/tarsal bones, and partial cutaneous syndactyly

10/24 Novoseek disease relationships for NOG gene (see all 24 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
symphalangism, proximal	93.90	16	11846737 (2), 11545688 (1), 7557985 (1), 18096605 (1) (see all 11)
syns1	91.86	5	11562478 (2), 16151340 (1), 18440889 (1), 12089654 (1)
brachydactyly, type b	78.55	2	18440889 (1), 11932993 (1)
fibrodysplasia ossificans progressiva	78.52	8	12672843 (1), 18019378 (1), 19400542 (1), 11503156 (1) (see all 7)
synostosis	68.86	10	18096605 (1), 18449926 (1), 15736221 (1), 17668388 (1) (see all 7)
conductive hearing loss	66.73	3	18096605 (1), 18983945 (1), 15699718 (1)
craniosynostosis	57.46	6	17437358 (2), 19182668 (1), 12687003 (1)
arthrodesis	55.32	7	12621334 (2), 16353259 (1), 12955858 (1), 12089654 (1) (see all 6)
hyperopia	45.76	3	12621334 (1), 18983945 (1), 12089654 (1)
osteolytic	37.72	11	17200191 (2), 19111821 (2), 16750435 (1), 16995812 (1) (see all 6)

About this table

Human Gene Mutation Database: NOG
Genetic Association Database: NOG
Human Genome Epidemiology Navigator: NOG (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/301 PubMed articles for NOG gene (see all 301 ):

Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism. (PubMed id 11545688)^{1, 2, 3, 4} Dixon M.E....Bamshad M. (2001)
Identification of mammalian noggin and its expression in the adult nervous system. (PubMed id 7666191)^{1, 2, 3, 4} Valenzuela D.M....Yancopoulos G.D. (1995)
Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. (PubMed id 10080184)^{1, 2, 3, 4} Gong Y....Warman M.L. (1999)
Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism. (PubMed id 11857750)^{1, 3, 4} Mangino M.... Dallapiccola B. (2002)
Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome. (PubMed id 11846737)^{1, 3, 4} Takahashi T.... Takada G. (2001)
A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. (PubMed id 17668388)^{1, 3, 4} Lehmann K.... Mundlos S. (2007)
Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin. (PubMed id 12089654)^{1, 3, 4} Brown D.J.... Lesperance M.M. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs). (PubMed id 12404109)^{3, 6} Felder B....Koch M.C. (2002)
Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases. (PubMed id 17200191)^{1, 3} Schwaninger R....Cecchini M.G. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9241	HGNC: 7866	AceView: NOG	Ensembl:ENSG00000183691	euGenes: HUgn9241
ECgene: NOG	H-InvDB: NOG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NOG	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=NOG

Licensable Technologies for NOG
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NOG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NOG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NOG		Antibodies for NOG
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NOG		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NOG)
	Antibodies (NOG)
	Chimera RNAi (NOG)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Noggin)
	Antibodies (Noggin)

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Antibodies for NOG

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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NOG Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for NOG

Summaries
for NOG

Genomic Location
for NOG

Proteins
for NOG

Protein Domains/
Families
for NOG

Gene Function
for NOG

Pathways & Interactions
for NOG

Drugs & Compounds
for NOG

Transcripts
for NOG

Expression
for NOG

Orthologs
for NOG

Paralogs
for NOG

SNPs/Variants
for NOG

Disorders & Mutations
for NOG

Medical News
for NOG

Publications
for NOG

Search for NOG

Genome Databases showing NOG

Other Databases showing NOG

Specialized Databases showing NOG

Licensable Technologies
for NOG

Services
for NOG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NOG Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor NOG

Summariesfor NOG

Genomic Locationfor NOG

Proteinsfor NOG

Protein Domains/Familiesfor NOG

Gene Functionfor NOG

Pathways & Interactionsfor NOG

Drugs & Compoundsfor NOG

Transcriptsfor NOG

Expression for NOG

Orthologsfor NOG

Paralogsfor NOG

SNPs/Variantsfor NOG

Disorders & Mutationsfor NOG

Medical Newsfor NOG

Publicationsfor NOG

Search for NOG

Genome Databases showing NOG

Other Databases showing NOG

Specialized Databases showing NOG

Licensable Technologiesfor NOG

Servicesfor NOG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NOG

Summaries
for NOG

Genomic Location
for NOG

Proteins
for NOG

Protein Domains/
Families
for NOG

Gene Function
for NOG

Pathways & Interactions
for NOG

Drugs & Compounds
for NOG

Transcripts
for NOG

Expression
for NOG

Orthologs
for NOG

Paralogs
for NOG

SNPs/Variants
for NOG

Disorders & Mutations
for NOG

Medical News
for NOG

Publications
for NOG

Licensable Technologies
for NOG

Services
for NOG