NOD2 Gene
protein-coding GIFtS: 60
GCID: GC16P050729
|
|
nucleotide-binding oligomerization domain containing 2(Previous names: caspase recruitment domain family, member 15 )
(Previous symbols: IBD1, CARD15)
| |
Aliases
for NOD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleotide-Binding Oligomerization Domain Containing 21 2 | | Inflammatory Bowel Disease Protein 12 3 | | CARD151 2 3 5 | | ACUG2 5 | | IBD11 2 3 5 | | NOD2B2 | | CD1 2 5 | | Caspase Recruitment Domain Protein 152 | | PSORAS11 2 5 | | NLR Family, CARD Domain Containing 22 | | BLAU1 2 | | NOD-Like Receptor C22 | | CLR16.31 2 | | Nucleotide-Binding Oligomerization Domain 22 | | NLRC21 2 | | Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD DomainContaining 22 | | Caspase Recruitment Domain Family, Member 151 2 | | Nucleotide-Binding Oligomerization Domain-Containing Protein 22 | | Caspase Recruitment Domain-Containing Protein 152 3 | | |
Export aliases for NOD2 gene to outside databasesPrevious GC identifers: GC16P049289 GC16P050731 GC16P036618 |
Summaries
for NOD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NOD2:
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains andsix leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays arole in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide(MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohndisease and Blau syndrome. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NOD2_HUMAN, Q9HC29Function: Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. Confers responsiveness to intracellular bacteriallipopolysaccharides (LPS)
Gene Wiki entry for NOD2
|
Genomic Views
for NOD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOD2 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q21 Ensembl cytogenetic band: 16q12.1 HGNC cytogenetic band: 16q12NOD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P050729: view genomic region
(about GC identifiers)
Start:
|
50,727,514 bp from pter |
End:
|
50,766,988 bp from pter |
Size:
|
39,475 bases |
Orientation:
|
plus strand |
|
Proteins
for NOD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOD2_HUMAN, Q9HC29 (See
protein sequence)Recommended Name: Nucleotide-binding oligomerization domain-containing protein 2 Size: 1040 amino acids; 115283 Da
Subunit: Binds to RIPK2/RICK by CARD-CARD interaction. Interacts with ATG16L1
Subcellular location: Cytoplasm
Secondary accessions: Q96RH5 Q96RH6 Q96RH8Alternative initiation: 2 isoforms: Q9HC29-1 Q9HC29-2 (Can activate NF-kappa-B)Explore the universe of human proteins at neXtProt for NOD2: NX_Q9HC29
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HC29
NOD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071445.1
ENSEMBL proteins: ENSP00000431681 ENSP00000300589 ENSP00000435149 ENSP00000463145 ENSP00000462443 ENSP00000464065 ENSP00000463423 ENSP00000437246 Reactome Protein details: Q9HC29
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
NOD2 for ontologies About GeneDecksing
NOD2 Antibody Products:
Assay Products for NOD2: |
Protein
Domains /
Families
for NOD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOD2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HC29ProtoNet protein and cluster: Q9HC29 1 Blocks protein family: IPB001315 CARD interaction domain
UniProtKB/Swiss-Prot: NOD2_HUMAN, Q9HC29Domain: The ATG16L1-binding motif mediates interaction with ATG16L1 (PubMed:23376921)Similarity: Contains 2 CARD domainsSimilarity: Contains 9 LRR (leucine-rich) repeatsSimilarity: Contains 1 NACHT domain |
Function
for NOD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NOD2_HUMAN, Q9HC29Function: Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. Confers responsiveness to intracellular bacteriallipopolysaccharides (LPS)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NOD2 (NM_022162) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOD2 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
NOD2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for NOD2: Nod2tm1Vmd Nod2tm1Flv Nod2tm1Jhgt Nod2tm1Mka Nod2tm1Pmu
8 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Nod2):
NOD2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NOD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | | | 3 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | | | 4 | Immune System | | | 5 | Cytokine Signaling in Immune system | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NOD2
5/30 
Reactome Pathways for NOD2 (see all 30)
3 
Kegg Pathways (Kegg details for NOD2):
NOD2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOD2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/43 Interacting proteins for NOD2 (Q9HC292, 3 ENSP000003005894) via UniProtKB, MINT, STRING, and/or I2D (see all 43)About this table
Gene Ontology (GO): 5/83 biological process terms (GO ID links to tree view) (see all 83): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000187 | activation of MAPK activity |
TAS | -- | | GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002227 | innate immune response in mucosa |
IEA | -- | | GO:0002253 | activation of immune response |
-- | -- | | GO:0002282 | microglial cell activation involved in immune response |
IEA | -- |
NOD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NOD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NOD2 for compounds About GeneDecksing
 Browse Tocris compounds for NOD2
10/17 Novoseek chemical compound relationships for NOD2 gene (see all 17) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| muramyl dipeptide |
86.4 |
38 |
18647246 (6), 18243161 (2), 18096043 (2), 17100619 (2) (see all 13) |
| peptidoglycan |
80.7 |
82 |
15330254 (3), 12514169 (3), 18385071 (3), 12626759 (2) (see all 47) |
| fk 565 |
74.9 |
4 |
16637007 (3), 18231574 (1) |
| diaminopimelic acid |
59.4 |
1 |
18809654 (1) |
| il 10 |
45 |
2 |
16389181 (1), 19349988 (1), 19381138 (1) |
| infliximab |
36.4 |
5 |
12360101 (3), 17207093 (1) |
| lactulose |
21.1 |
1 |
16000642 (1) |
| mannose |
11.7 |
1 |
17100626 (1) |
| nitric oxide |
5.52 |
2 |
20106130 (1), 16503465 (1) |
| endotoxin |
1.89 |
3 |
15016407 (2), 18382655 (1) |
Search CenterWatch for drugs/clinical trials and news about NOD2
|
Transcripts
for NOD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOD2 gene: NM_022162.1 Unigene Cluster for NOD2: Nucleotide-binding oligomerization domain containing 2 Hs.592072 [show with all ESTs]Unigene Representative Sequence: AF17893010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000526417 ENST00000531674(uc010cbj.1) ENST00000300589(uc021tia.1 uc010cbk.1 uc002egl.1 uc010cbl.1 uc010cbm.1 uc010cbn.1 uc010cbo.1 uc010cbq.1 uc002egm.1 uc010vgq.1)
ENST00000527070 ENST00000532206 ENST00000534067 ENST00000529633(uc010cbr.1)
ENST00000524712(uc010cbp.1) ENST00000527052 ENST00000534057
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NOD2 (NM_022162) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOD2 |
Additional cDNA sequence: AF178930.1 AK298099.1 AY187233.1 AY187234.1 AY187235.1 AY187236.1 AY187237.1 AY187238.1 AY187239.1 AY187240.1 AY187241.1 AY187242.1 AY187243.1 AY187244.1 AY187245.1 AY187246.1 AY423901.1 DQ868973.1 HQ204571.1 4 DOTS entries: DT.428502 DT.97820421 DT.101976045 DT.101983771 24/26 AceView cDNA sequences (see all 26): AY187245 AY187242 AY187239 AI681116 AY187241 AY187244 AY187240 BE327441 AF178930 AY187233 AY187235 AY187237 AY187234 NM_022162 BX380580 AY187236 BF475303 AW517524 AA910520 AY187243 AY187246 AY187238 AA775466 AL702982
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NOD2 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NOD2
|
Expression
for NOD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGTGAACT
About this image
See NOD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOD2
SOURCE GeneReport for Unigene cluster: Hs.592072
UniProtKB/Swiss-Prot: NOD2_HUMAN, Q9HC29Tissue specificity: Monocytes-specific
SABiosciences Expression via Pathway-Focused PCR Arrays including NOD2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOD2 |
Orthologs
for NOD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NOD2 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
nod21 |
nucleotide-binding oligomerization domain containing more |
54.05(n)
49.79(a) |
|
777696 XM_692832.4 XP_697924.3 |
ENSEMBL Gene Tree for NOD2 (if available)
TreeFam Gene Tree for NOD2 (if available) |
Paralogs
for NOD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NOD2 gene
- NLRC52 NOD12 CIITA2
3 SIMAP similar genes for NOD2 using alignment to 18 protein entries: NOD2_HUMAN (see all proteins):CARD15 NOD2/CARD15 NOD1
NOD2 for paralogs About GeneDecksing
|
Genomic Variants
for NOD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NOD2 (50727514 - 50766988 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NOD2: --
Human Gene Mutation Database (HGMD): NOD2
Locus Specific Mutation Databases (LSDB): NOD2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOD2 |
|
Disorders
/ Diseases
for NOD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NOD2 for disorders About GeneDecksing
OMIM gene information: 605956
OMIM disorders: 266600 186580 607507 609464
UniProtKB/Swiss-Prot: NOD2_HUMAN, Q9HC29
Defects in NOD2 are the cause of Blau syndrome (BS) [MIM:186580]. BS is a rare autosomal dominant disordercharacterized by early-onset granulomatous arthritis, uveitis and skin rash Defects in NOD2 are a cause of susceptibility to inflammatory bowel disease type 1 (IBD1) [MIM:266600]. IBD1is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided intoCrohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract fromthe mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmuraland discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, inulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas andgranulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints Defects in NOD2 are the cause of sarcoidosis early-onset (EOS) [MIM:609464]. EOS is a form of sarcoidosismanifesting in children younger than 4 years of age. Sarcoidosis is an idiopathic, systemic, inflammatory diseasecharacterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs andthe lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Early-onset sarcoidosis isquite rare and has a distinct triad of skin, joint and eye disorders, without apparent pulmonary involvement. Comparedwith an asymptomatic and sometimes naturally disappearing course of the disease in older children, early-onsetsarcoidosis is progressive and in many cases causes severe complications, such as blindness, joint destruction andvisceral involvement
20/111  diseases for NOD2 (see all 111): About MalaCardsinflammatory bowel disease blau syndrome crohn's disease pyoderma gangrenosum
graft versus host disease familial mediterranean fever diffuse large b-cell lymphoma acute graft versus host disease
hidradenitis suppurativa sclerosing cholangitis b-cell lymphomas primary sclerosing cholangitis
psoriatic arthritis pyoderma guttate psoriasis non-hodgkin lymphoma
inflammatory bowel disease 1 hidradenitis wegener's granulomatosis rheumatoid arthritis
5 diseases from the University of Copenhagen DISEASES database for NOD2:Crohn's disease Blau syndrome Ulcerative colitis Uveitis
Sarcoidosis 10/50 Novoseek disease relationships for NOD2 gene (see all 50) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| blau syndrome |
95.8 |
90 |
12428248 (6), 20298285 (5), 17207093 (4), 19116920 (4) (see all 38) |
| ileal diseases |
91.7 |
21 |
14555911 (4), 16167972 (2), 14570728 (2), 17538984 (1) (see all 13) |
| inflammatory bowel diseases |
87.8 |
62 |
17978873 (5), 17451203 (2), 15967635 (2), 19570976 (2) (see all 47) |
| colitis ulcerative |
84.5 |
30 |
15052696 (2), 12019209 (1), 15095125 (1), 17538984 (1) (see all 26) |
| colonic diseases |
67.6 |
1 |
18213697 (1) |
| genetic susceptibility |
67.3 |
12 |
12555995 (1), 17206682 (1), 18473763 (1), 14996717 (1) (see all 11) |
| ileitis |
63.7 |
3 |
16167972 (1), 14570728 (1), 19079235 (1) |
| uveitis |
63.6 |
30 |
18385071 (5), 18219096 (3), 19098321 (3), 14597055 (3) (see all 9) |
| inflammation |
57.5 |
61 |
15539413 (3), 19098321 (3), 15479689 (2), 18305068 (2) (see all 42) |
| colitis |
54.1 |
14 |
19079230 (2), 15095125 (1), 17538984 (1), 19737867 (1) (see all 9) |
Genetic Association Database (GAD): NOD2
Human Genome Epidemiology (HuGE) Navigator: NOD2 (463 documents)
Export disorders for NOD2 gene to outside databases
|
Publications
for NOD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOD2 gene, integrated from 9 sources (see all 874):
(articles sorted by number of sources associating them with NOD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. (PubMed id 11385576)1, 2, 4 Hugot J.-P.... Thomas G. (2001)
- Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. (PubMed id 11087742)1, 2, 9 Ogura Y.... Nunez G. (2001)
- A novel mutation in the NOD2 gene associated with Blau syndrome: a Norwegian family with four affected members. (PubMed id 19169908)1, 2, 9 Milman N....Hansen T.V. (2009)
- ITCH K63-ubiquitinates the NOD2 binding protein, RIP2 , to influence inflammatory signaling pathways. (PubMed id 19592251)1, 2, 9 Tao M....Abbott D.W. (2009)
- A new CARD15 mutation in Blau syndrome. (PubMed id 15812565)1, 2, 9 van Duist M.M.... De Marchi M. (2005)
- Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome. (PubMed id 15459013)1, 2, 9 Kanazawa N.... Miyachi Y. (2005)
- CARD15 mutations in Blau syndrome. (PubMed id 11528384)1, 2, 9 Miceli-Richard C....Hugot J.-P. (2001)
- Mapping of a susceptibility locus for Crohn's disease on chromosome 16. (PubMed id 8587604)1, 3 Hugot J.P....Thomas G. (1996)
- Molecular evidence for two forms of Crohn disease. (PubMed id 7809109)1, 3 Gilberts E.C....Greenstein R.J. (1994)
- The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis. (PubMed id 17705850)1, 9 Lala S....Zumla A. (2007)
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External Searches for NOD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NOD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NOD2 gene
(According to HUGE)
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Specialized Databases showing NOD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOD2 | Pharmacogenomics, SNPs, Pathways | | INFEVERS | http://fmf.igh.cnrs.fr/ISSAID/infevers/search.php?n=6 | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NOD2 |
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About This Section
| Patent Information for NOD2 gene:
Search GeneIP for patents involving NOD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NOD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for NOD2 | | OriGene shRNA RFP for NOD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOD2 | | | OriGene Protein Over-expression Lysate for NOD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NOD2 | | OriGene 3'-UTR Clone for NOD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NOD2 | | OriGene Custom Protein Services for NOD2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOD2 |
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| | | | Search Tocris compounds for NOD2 |
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 | | | NOD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOD2 |
|  |  |  | | | | ThermoFisher Antibodies for NOD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOD2 |
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