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Aliases for NOD1 Gene

Aliases for NOD1 Gene

  • Nucleotide-Binding Oligomerization Domain Containing 1 2 3
  • CARD4 3 4 6
  • Caspase Recruitment Domain-Containing Protein 4 3 4
  • Caspase Recruitment Domain Family, Member 4 2 3
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 1 3
  • Nucleotide-Binding Oligomerization Domain-Containing Protein 1 3
  • Leucine Rich Repeat And CARD Domain Containing 1 2
  • Nucleotide-Binding Oligomerization Domain 2
  • NLR Family, CARD Domain Containing 1 3
  • CARD Domain Containing 1 2
  • NLR Family 2
  • CLR7.1 3
  • NLRC1 3

External Ids for NOD1 Gene

Previous Symbols for NOD1 Gene

  • CARD4

Summaries for NOD1 Gene

Entrez Gene Summary for NOD1 Gene

  • This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009]

GeneCards Summary for NOD1 Gene

NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1) is a Protein Coding gene. Diseases associated with NOD1 include blau syndrome. Among its related pathways are Salmonella infection (KEGG) and Interferon Signaling. GO annotations related to this gene include protein homodimerization activity and cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is NLRX1.

UniProtKB/Swiss-Prot for NOD1 Gene

  • Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.

Gene Wiki entry for NOD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOD1 Gene

Genomics for NOD1 Gene

Genomic Location for NOD1 Gene

Start:
30,424,527 bp from pter
End:
30,478,784 bp from pter
Size:
54,258 bases
Orientation:
Minus strand

Genomic View for NOD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOD1 Gene

Regulatory Elements for NOD1 Gene

Proteins for NOD1 Gene

  • Protein details for NOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y239-NOD1_HUMAN
    Recommended name:
    Nucleotide-binding oligomerization domain-containing protein 1
    Protein Accession:
    Q9Y239
    Secondary Accessions:
    • B4DTU3
    • Q549U4
    • Q8IWF5

    Protein attributes for NOD1 Gene

    Size:
    953 amino acids
    Molecular mass:
    107691 Da
    Quaternary structure:
    • Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2. Interacts with NLRP10 and recruits it to the cell membrane following invasive bacterial infection. Interacts with RNF34.

    Three dimensional structures from OCA and Proteopedia for NOD1 Gene

    Alternative splice isoforms for NOD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOD1 Gene

Proteomics data for NOD1 Gene at MOPED

Post-translational modifications for NOD1 Gene

  • Ubiquitinated. Lys-48-linked polyubiquitination by RNF34 promotes proteasomal degradation and thereby negatively regulates NOD1 for instance in NF-kappa-B activition.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOD1 Gene

No data available for DME Specific Peptides for NOD1 Gene

Domains for NOD1 Gene

Gene Families for NOD1 Gene

HGNC:
  • NLR :Nucleotide-binding domain and leucine rich repeat containing
IUPHAR :

Protein Domains for NOD1 Gene

UniProtKB/Swiss-Prot:

NOD1_HUMAN
Domain:
  • Contains 1 CARD domain.:
    • Q9Y239
  • Contains 1 NACHT domain.:
    • Q9Y239
Similarity:
  • Contains 9 LRR (leucine-rich) repeats.:
    • Q9Y239
genes like me logo Genes that share domains with NOD1: view

Function for NOD1 Gene

Molecular function for NOD1 Gene

UniProtKB/Swiss-Prot Function: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.

Gene Ontology (GO) - Molecular Function for NOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15107016
GO:0005524 ATP binding IEA --
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process TAS 10329646
GO:0042802 identical protein binding IPI 18186648
GO:0042803 protein homodimerization activity IPI 18186648
genes like me logo Genes that share ontologies with NOD1: view

Phenotypes for NOD1 Gene

genes like me logo Genes that share phenotypes with NOD1: view

Animal Models for NOD1 Gene

MGI Knock Outs for NOD1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NOD1 Gene

Localization for NOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOD1 Gene

Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOD1 Gene COMPARTMENTS Subcellular localization image for NOD1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for NOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 15967716
GO:0005829 cytosol TAS --
GO:0016323 basolateral plasma membrane IDA 19043560
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with NOD1: view

Pathways for NOD1 Gene

genes like me logo Genes that share pathways with NOD1: view

Gene Ontology (GO) - Biological Process for NOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with NOD1: view

Compounds for NOD1 Gene

(1) IUPHAR Ligand for NOD1 Gene

Ligand Type Action Affinity Pubmed IDs
meso-DAP Agonist Agonist

(4) Novoseek inferred chemical compound relationships for NOD1 Gene

Compound -log(P) Hits PubMed IDs
fk 565 91.7 3
peptidoglycan 83.9 28
muramyl dipeptide 82.1 3
diaminopimelic acid 72 2
genes like me logo Genes that share compounds with NOD1: view

Transcripts for NOD1 Gene

Unigene Clusters for NOD1 Gene

Nucleotide-binding oligomerization domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - - -
SP3:
SP4: - - - - - -
SP5: -

Relevant External Links for NOD1 Gene

GeneLoc Exon Structure for
NOD1
ECgene alternative splicing isoforms for
NOD1

Expression for NOD1 Gene

mRNA expression in normal human tissues for NOD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NOD1 Gene

SOURCE GeneReport for Unigene cluster for NOD1 Gene Hs.405153

mRNA Expression by UniProt/SwissProt for NOD1 Gene

Q9Y239-NOD1_HUMAN
Tissue specificity: Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon
genes like me logo Genes that share expressions with NOD1: view

Orthologs for NOD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOD1 36
  • 99.23 (n)
  • 99.58 (a)
NOD1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOD1 36
  • 86.08 (n)
  • 83.32 (a)
NOD1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOD1 36
  • 86.36 (n)
  • 83.84 (a)
NOD1 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nod1 36
  • 81.97 (n)
  • 81.62 (a)
Nod1 16
Nod1 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOD1 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOD1 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nod1 36
  • 81.36 (n)
  • 81.53 (a)
chicken
(Gallus gallus)
Aves NOD1 36
  • 64.33 (n)
  • 63 (a)
NOD1 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOD1 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nod1 36
  • 58 (n)
  • 53.29 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6216 36
zebrafish
(Danio rerio)
Actinopterygii nod1 36
  • 58.37 (n)
  • 51.96 (a)
nod1 37
  • 50 (a)
OneToOne
Species with no ortholog for NOD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOD1 Gene

ENSEMBL:
Gene Tree for NOD1 (if available)
TreeFam:
Gene Tree for NOD1 (if available)

Paralogs for NOD1 Gene

Paralogs for NOD1 Gene

Selected SIMAP similar genes for NOD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NOD1: view

Variants for NOD1 Gene

Sequence variations from dbSNP and Humsavar for NOD1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs741889 -- 30,426,605(-) AGAGG(A/C)ATGTG intron-variant
rs932272 -- 30,473,543(-) GATAC(C/T)GATAT intron-variant
rs963804 -- 30,424,562(-) TTGCC(A/C)GCTCA utr-variant-3-prime
rs1076591 -- 30,426,606(-) GAGAG(C/G)CATGT intron-variant
rs2037955 -- 30,472,333(-) CAGTG(G/T)GTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOD1 Gene

Variant ID Type Subtype PubMed ID
nsv436557 CNV Deletion 17901297
esv2665927 CNV Deletion 23128226
esv2657686 CNV Deletion 23128226

Relevant External Links for NOD1 Gene

HapMap Linkage Disequilibrium report
NOD1
Human Gene Mutation Database (HGMD)
NOD1

Disorders for NOD1 Gene

(1) MalaCards Diseases for NOD1 Gene

Search for NOD1 Gene in MalaCards »

(3) University of Copenhagen DISEASES for NOD1 Gene

(11) Novoseek inferred disease relationships for NOD1 Gene

Disease -log(P) Hits PubMed IDs
inflammatory bowel diseases 62.7 7
colitis ulcerative 42.1 3
bacterial infections 41 3
genetic susceptibility 40.9 2
inflammation 33.3 5

Relevant External Links for NOD1

Genetic Association Database (GAD)
NOD1
Human Genome Epidemiology (HuGE) Navigator
NOD1
genes like me logo Genes that share disorders with NOD1: view

No data available for UniProtKB/Swiss-Prot for NOD1 Gene

Publications for NOD1 Gene

  1. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor- kappaB. (PMID: 10329646) Inohara N. … Nunez G. (J. Biol. Chem. 1999) 2 3 4 23
  2. Association of NOD1 polymorphisms with atopic eczema and related phenotypes. (PMID: 15990792) Weidinger S. … Illig T. (J. Allergy Clin. Immunol. 2005) 3 23 49
  3. A functional variant in the CARD4 gene and risk of premature coronary heart disease. (PMID: 16893397) El Mokhtari N.E. … Schreiber S. (Int. J. Immunogenet. 2006) 3 23 49
  4. Human Nod1 confers responsiveness to bacterial lipopolysaccharides. (PMID: 11058605) Inohara N. … Nunez G. (J. Biol. Chem. 2001) 3 4 23
  5. Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis. (PMID: 17309748) Hofner P. … MA!ndi Y. (Helicobacter 2007) 3 23 49

Products for NOD1 Gene

Sources for NOD1 Gene

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