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NOD1 Gene

protein-coding   GIFtS: 62
GCID: GC07M030464

Nucleotide-Binding Oligomerization Domain Containing 1

(Previous names: caspase recruitment domain family, member 4)
(Previous symbol: CARD4)
  See NOD1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleotide-Binding Oligomerization Domain Containing 11 2     Nucleotide-Binding Oligomerization Domain1
CARD41 2 3 5     CLR7.12
Caspase Recruitment Domain Family, Member 41 2     NLRC12
Caspase Recruitment Domain-Containing Protein 42 3     NLR Family, CARD Domain Containing 12
CARD Domain Containing 11     Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD
Domain Containing 12
Leucine Rich Repeat And CARD Domain Containing 11     Nucleotide-Binding Oligomerization Domain-Containing Protein 12
NLR Family1     

External Ids:    HGNC: 163901   Entrez Gene: 103922   Ensembl: ENSG000001061007   OMIM: 6059805   UniProtKB: Q9Y2393   

Export aliases for NOD1 gene to outside databases

Previous GC identifers: GC07M030431 GC07M030346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOD1 Gene:
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a
cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located
nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is
involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may
affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular
pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the
detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the
5' UTR have been described, but the full-length nature of these variants has not been determined. (provided by
RefSeq, Oct 2009)

GeneCards Summary for NOD1 Gene:
NOD1 (nucleotide-binding oligomerization domain containing 1) is a protein-coding gene. Diseases associated with NOD1 include blau syndrome. GO annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process and protein homodimerization activity. An important paralog of this gene is NLRC5.

UniProtKB/Swiss-Prot: NOD1_HUMAN, Q9Y239
Function: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers
responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along
with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and
RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in
sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector
proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection

Gene Wiki entry for NOD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOD1 gene promoter:
         C/EBPbeta   p53   XBP-1   FOXL1   C/EBPalpha   RORalpha1   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOD1 promoter sequence
   Search Chromatin IP Primers for NOD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p14   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p15-p14

NOD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOD1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M030464:  view genomic region     (about GC identifiers)

Start:
30,464,143 bp from pter      End:
30,518,400 bp from pter
Size:
54,258 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 30,513,913-30,568,158     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NOD1_HUMAN, Q9Y239 (See protein sequence)
Recommended Name: Nucleotide-binding oligomerization domain-containing protein 1  
Size: 953 amino acids; 107691 Da
Subunit: Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with
ARHGEF2. Interacts with NLRP10 and recruits it to the cell membrane following invasive bacterial infection
5 PDB 3D structures from and Proteopedia for NOD1:
2B1W (3D)        2DBD (3D)        2NSN (3D)        2NZ7 (3D)        4E9M (3D)    
Secondary accessions: Q549U4 Q8IWF5

Explore the universe of human proteins at neXtProt for NOD1: NX_Q9Y239

Explore proteomics data for NOD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NOD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006083.1  
    ENSEMBL proteins: 
     ENSP00000222823   ENSP00000416946   ENSP00000399505   ENSP00000396046   ENSP00000395551  
     ENSP00000410917   ENSP00000409416  
    Reactome Protein details: Q9Y239

    NOD1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for NOD1
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    Novus Biologicals NOD1 Proteins
    Novus Biologicals NOD1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOD1

     
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    antibodies-online proteins for NOD1 (7 products) 

     
    antibodies-online peptides for NOD1

    NOD1 Antibody Products:

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    NOD1 Assay Products:

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    antibodies-online kits for NOD1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NLR: Nucleotide-binding domain and leucine rich repeat containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: NLRC1
    NOD-like receptor family

    3 InterPro protein domains:
     IPR007111 NACHT_NTPase
     IPR011029 DEATH-like_dom
     IPR001315 CARD

    Graphical View of Domain Structure for InterPro Entry Q9Y239

    ProtoNet protein and cluster: Q9Y239

    2 Blocks protein domains:
    IPB001315 CARD interaction domain
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: NOD1_HUMAN, Q9Y239
    Similarity: Contains 1 CARD domain
    Similarity: Contains 9 LRR (leucine-rich) repeats
    Similarity: Contains 1 NACHT domain


    Find genes that share domains with NOD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOD1_HUMAN, Q9Y239
    Function: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers
    responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along
    with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and
    RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in
    sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector
    proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15107016
    GO:0005524ATP binding IEA--
    GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process TAS10329646
    GO:0042802identical protein binding IPI18186648
    GO:0042803protein homodimerization activity IPI18186648
         
    Find genes that share ontologies with NOD1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nod1):
     hematopoietic system  immune system 

    Find genes that share phenotypes with NOD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NOD1: Nod1tm1Inoh Nod1tm1Bert

       genOway: Develop your customized and physiologically relevant rodent model for NOD1

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate NOD1:
    hsa-miR-495 hsa-miR-593* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-924 hsa-miR-605 hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidNOD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOD1
    Predesigned siRNA for gene silencing in human, mouse, rat NOD1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NOD1 (NM_006092)
    Sino Biological Human cDNA Clone for NOD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOD1

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOD1_HUMAN, Q9Y239: Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in
    the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the
    cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus2
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm TAS15967716
    GO:0005829cytosol TAS--
    GO:0016323basolateral plasma membrane IDA19043560
    GO:0016324apical plasma membrane IEA--

    Find genes that share ontologies with NOD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NOD1 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68
    NOD pathway0.33
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    3MAPK targets/ Nuclear events mediated by MAP kinases
    MAP kinase activation in TLR cascade0.61
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK10.00
    activated TAK1 mediates p38 MAPK activation0.00
    4Interferon Signaling
    Cytokine Signaling in Immune system0.59
    5NOD-like Receptor Signaling Pathways
    NOD-like Receptor Signaling Pathways0.58


    Find genes that share SuperPaths with NOD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NOD1
        NOD-like Receptor Signaling Pathways


    2 Cell Signaling Technology (CST) Pathways for NOD1
        Apoptosis and Autophagy
    NF-kappaB Signaling

    1 BioSystems Pathway for NOD1
        NOD pathway


    5 Reactome Pathways for NOD1
        Interleukin-1 signaling
    activated TAK1 mediates p38 MAPK activation
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    NOD1/2 Signaling Pathway
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    4 Kegg Pathways  (Kegg details for NOD1):
        NOD-like receptor signaling pathway
    Epithelial cell signaling in Helicobacter pylori infection
    Shigellosis
    Pertussis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOD1 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NOD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOD1 (Q9Y2391, 2, 3 ENSP000002228234) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232804P081072, 3, ENSP000003930874MINT-62548 I2D: score=1 STRING: ENSP00000393087
    ENSG00000212866P081072, 3MINT-62548 I2D: score=1 
    ENSG00000215328P081072, 3MINT-62548 I2D: score=1 
    ENSG00000224501P081072, 3MINT-62548 I2D: score=1 
    ENSG00000231555P081072, 3MINT-62548 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002606positive regulation of dendritic cell antigen processing and presentation ISS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    Find genes that share ontologies with NOD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOD1

    1 IUPHAR Ligand for NOD1 (NLRC1)    About this table
    LigandTypeActionAffinityPubmed IDs
    meso-DAP
    AgonistAgonist--

    4 Novoseek inferred chemical compound relationships for NOD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fk 565 91.7 4 16637007 (1), 16299289 (1), 18231574 (1)
    peptidoglycan 83.9 37 12871942 (5), 16172124 (3), 15330254 (2), 16446438 (1) (see all 21)
    muramyl dipeptide 82.1 4 15617523 (1), 17100619 (1), 16299289 (1)
    diaminopimelic acid 72 3 16172124 (1), 17100619 (1)



    Find genes that share compounds with NOD1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOD1 gene: 
    NM_006092.2  

    Unigene Cluster for NOD1:

    Nucleotide-binding oligomerization domain containing 1
    Hs.405153  [show with all ESTs]
    Unigene Representative Sequence: NM_006092
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222823(uc003tav.3 uc010kvs.2 uc010kvt.2 uc010kvu.2)
    ENST00000434755 ENST00000489614 ENST00000467706 ENST00000413433 ENST00000411552(uc003tay.2)
    ENST00000419799(uc003tax.2) ENST00000419601 ENST00000423334
    miRNA
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    hsa-miR-495 hsa-miR-593* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-924 hsa-miR-605 hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidNOD1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat NOD1

    Additional mRNA sequence: 

    AF113925.1 AF126484.1 AK300367.1 AY128682.1 AY128683.1 AY128684.1 AY128685.1 AY128686.1 
    AY187249.1 BC040339.1 

    16 DOTS entries:

    DT.100760277  DT.313677  DT.100760279  DT.91676188  DT.95243302  DT.100760280  DT.100760278  DT.101983799 
    DT.40109209  DT.101983797  DT.101983798  DT.92000002  DT.99981798  DT.100000145  DT.121108225  DT.429111 

    Selected AceView cDNA sequences (see all 116):

    AI797914 AA242961 AI264354 BQ052832 AI696791 CA310179 AI424757 AY128685 
    AA242826 BC020114 AA394280 NM_006092 BM823418 AA987481 AK023969 AI640699 
    BC040339 AY128684 CB045578 BE855839 BU150407 AA845215 AY128686 AI246675 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NOD1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
    SP1:                                -                                   -                       -                                 
    SP2:                                -                       -                                   -                 -               
    SP3:                                                                                                                              
    SP4:                                                                    -           -     -     -     -           -               
    SP5:                                                                                                              -               


    ECgene alternative splicing isoforms for NOD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NOD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGTGGGGG
    NOD1 Expression
    About this image


    NOD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    NOD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405153

    UniProtKB/Swiss-Prot: NOD1_HUMAN, Q9Y239
    Tissue specificity: Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in
    placenta, lung, liver, kidney, thymus, testis, small intestine and colon

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NOD1 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NOD1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nod11 , 5 nucleotide-binding oligomerization domain containing more1, 5 81.97(n)1
    81.62(a)1
      6 (27.22 cM)5
    1076071  NM_001171007.11  NP_001164478.11 
     549239425 
    chicken
    (Gallus gallus)
    Aves NOD11 nucleotide-binding oligomerization domain containing more 64.33(n)
    63(a)
      420677  XM_418777.3  XP_418777.2 
    lizard
    (Anolis carolinensis)
    Reptilia NOD16
    nucleotide-binding oligomerization domain containi...
    60(a)
    1 ↔ 1
    6(36161303-36237003)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nod11 nucleotide-binding oligomerization domain containing more 58(n)
    53.29(a)
      100488164  XM_002937854.2  XP_002937900.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nod11 nucleotide-binding oligomerization domain containing more 58.37(n)
    51.96(a)
      100330810  XM_002665060.3  XP_002665106.3 


    ENSEMBL Gene Tree for NOD1 (if available)
    TreeFam Gene Tree for NOD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOD1 gene
    NLRC52  NOD22  NLRX12  NLRP12  CARD82  CIITA2  
    2 SIMAP similar genes for NOD1 using alignment to 5 protein entries:     NOD1_HUMAN (see all proteins):
    NOD2    NOD2/CARD15

    Find genes that share paralogs with NOD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOD1 (see all 1205)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1994759041,2
    Cuntested130537312(-) CCGAAA/C/TGGGGA 1 -- int10--------
    rs1994762641,2
    Cuntested130540566(-) TGGGCC/TGGGCG 1 -- int10--------
    rs1994759031,2
    Cuntested130540723(-) GCAGCA/C/GCCCTC 2 T A mis10--------
    rs1994759011,2
    Cuntested130541380(-) AGAGCC/TTCTTT 2 L F mis10--------
    rs596963871,2
    C--30470847(+) AATAA-/ATAA  
            
    TTCTG
    1 -- int10--------
    rs583646871,2
    C--30497976(+) GAGAG-/AGTAAAA 1 -- int10--------
    rs114305361,2
    C--30498356(+) TTTTT-/TGACAG 1 -- int1 trp30--------
    rs574296511,2
    C--30500021(+) CAGGC-/AAAGAGA 1 -- int10--------
    rs113138061,2
    C--30502565(+) AAAAAA/-GATTT 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs605959551,2
    C--30502565(+) AAAAAA/-GATTT 1 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for NOD1 (30464143 - 30518400 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NOD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665927CNV Deletion23128226
    nsv436557CNV Deletion17901297
    esv2657686CNV Deletion23128226

    Human Gene Mutation Database (HGMD): NOD1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOD1
    DNA2.0 Custom Variant and Variant Library Synthesis for NOD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605980    OMIM disorders: --

    1 disease for NOD1:    
    About MalaCards
    blau syndrome

    3 diseases from the University of Copenhagen DISEASES database for NOD1:
    Crohn's disease     Blau syndrome     Ulcerative colitis

    Find genes that share disorders with NOD1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NOD1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammatory bowel diseases 62.7 7 19570976 (2), 16172124 (1), 19327158 (1), 17133080 (1) (see all 6)
    colitis ulcerative 42.1 3 19723304 (2), 19327158 (1)
    bacterial infections 41 3 17690884 (2), 16172124 (1)
    genetic susceptibility 40.9 2 17948929 (1), 12477763 (1)
    inflammation 33.3 5 17690884 (2), 18574154 (1), 20124104 (1), 16493424 (1)
    colitis 23 1 19327158 (1)
    gastritis 14.3 3 17309748 (3)
    necrosis 0.496 4 17005562 (1), 10880512 (1), 12775719 (1), 10329646 (1)
    asthma 0 3 16172124 (1), 16893397 (1), 16021603 (1)
    tumors 0 8 16446438 (4), 17005562 (1), 10880512 (1), 12775719 (1) (see all 5)

    Genetic Association Database (GAD): NOD1
    Human Genome Epidemiology (HuGE) Navigator: NOD1 (45 documents)

    Export disorders for NOD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOD1 gene, integrated from 10 sources (see all 211):
    (articles sorted by number of sources associating them with NOD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor- kappaB. (PubMed id 10329646)1, 2, 3, 9 Inohara N.... Nunez G. (J. Biol. Chem. 1999)
    2. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. (PubMed id 10224040)1, 2, 3 Bertin J.... DiStefano P.S. (J. Biol. Chem. 1999)
    3. Nucleotide-binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand caucasian population: a case-control study. (PubMed id 19327158)1, 4, 9 Huebner C....Browning B.L. (BMC Res Notes 2009)
    4. Frequency of single nucleotide polymorphisms in NOD1 gene of ulcerative colitis patients: a case-control study in the Indian population. (PubMed id 19723304)1, 4, 9 Verma R....Paul J. (BMC Med. Genet. 2009)
    5. Human Nod1 confers responsiveness to bacterial lipopolysaccharides. (PubMed id 11058605)1, 2, 9 Inohara N.... Nunez G. (J. Biol. Chem. 2001)
    6. A functional variant in the CARD4 gene and risk of premature coronary heart disease. (PubMed id 16893397)1, 4, 9 El Mokhtari N.E....Schreiber S. (Int. J. Immunogenet. 2006)
    7. Association of NOD1 polymorphisms with atopic eczema and related phenotypes. (PubMed id 15990792)1, 4, 9 Weidinger S....Illig T. (J. Allergy Clin. Immunol. 2005)
    8. Monomer/dimer transition of the caspase-recruitment domain of human Nod1. (PubMed id 18186648)1, 2, 9 Srimathi T....Park Y.C. (Biochemistry 2008)
    9. Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis. (PubMed id 17309748)1, 4, 9 Hofner P....MA!ndi Y. (Helicobacter 2007)
    10. NOD1 gene E266K polymorphism is associated with disease susceptibility but not with disease phenotype or NOD2/CARD15 in Hungarian patients with Crohn's disease. (PubMed id 17964870)1, 4, 9 Molnar T....Lonovics J. (Dig Liver Dis 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10392 HGNC: 16390 AceView: CARD4 Ensembl:ENSG00000106100 euGenes: HUgn10392
    ECgene: NOD1 Kegg: 10392 H-InvDB: NOD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NOD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOD1 gene:
    Search GeneIP for patents involving NOD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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