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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NOD1 Gene

protein-coding GIFtS: 62
GCID: GC07M030464

nucleotide-binding oligomerization domain containing 1

(Previous names: caspase recruitment domain family, member 4 )
(Previous symbol: CARD4)

Explore 47 diseases affiliated with
NOD1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nucleotide-Binding Oligomerization Domain Containing 1¹ ²		Caspase Recruitment Domain-Containing Protein 4² ³
CARD4¹ ² ³ ⁵		NLR Family, CARD Domain Containing 1²
CLR7.1¹ ²		Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 1²
NLRC1¹ ²		Nucleotide-Binding Oligomerization Domain-Containing Protein 1²
Caspase Recruitment Domain Family, Member 4¹ ²

External Ids:	HGNC: 16390¹	Entrez Gene: 10392²	Ensembl: ENSG00000106100⁷	OMIM: 605980⁵	UniProtKB: Q9Y239³

Export aliases for NOD1 gene to outside databases

Previous GC identifers: GC07M030431 GC07M030346

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOD1:

This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic

protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain

(NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs

participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and

subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that

initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.

Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length

nature of these variants has not been determined. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: NOD1_HUMAN, Q9Y239

Function: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers

responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with

ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2

dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing

peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2

and OspB. Recruits NLRP10 to the cell membrane following bacterial infection

Gene Wiki entry for NOD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NOD1 gene promoter:
C/EBPbeta p53 XBP-1 FOXL1 C/EBPalpha RORalpha1 POU2F1a FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NOD1 promoter sequence

Search SABiosciences Chromatin IP Primers for NOD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p14 Ensembl cytogenetic band: 7p14.3 HGNC cytogenetic band: 7p15-p14

NOD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOD1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M030464: view genomic region (about GC identifiers)

Start:	30,464,143 bp from pter	End:	30,518,400 bp from pter
Size:	54,258 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 30,513,913-30,568,158

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NOD1_HUMAN, Q9Y239 (See protein sequence)

Recommended Name: Nucleotide-binding oligomerization domain-containing protein 1

Size: 953 amino acids; 107691 Da

Subunit: Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2.

Interacts with NLRP10 and recruits it to the cell membrane following invasive bacterial infection

Subcellular location: Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the

cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell

membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells

5 PDB 3D structures from and Proteopedia for NOD1:

2B1W (3D)

2DBD (3D)

2NSN (3D)

2NZ7 (3D)

4E9M (3D)

Secondary accessions: Q549U4 Q8IWF5

Explore the universe of human proteins at neXtProt for NOD1: NX_Q9Y239

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y239

NOD1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006083.1

ENSEMBL proteins:

ENSP00000222823 ENSP00000416946 ENSP00000399505 ENSP00000396046 ENSP00000395551

ENSP00000410917 ENSP00000409416

Reactome Protein details: Q9Y239
Human Recombinant Protein Products:

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	Novus Biologicals NOD1 Proteins Novus Biologicals NOD1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NOD1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	TAS	15967716
GO:0005829	cytosol	TAS	--
GO:0016323	basolateral plasma membrane	IDA	19043560
GO:0016324	apical plasma membrane	IEA	--

NOD1 for ontologies About GeneDecksing

NOD1 Antibody Products:

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Assay Products for NOD1:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NOD1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NOD1 for domains About GeneDecksing

3 InterPro domains/families:

IPR007111 NACHT_NTPase

IPR011029 DEATH-like_dom

IPR001315 CARD

Graphical View of Domain Structure for InterPro Entry Q9Y239

ProtoNet protein and cluster: Q9Y239

2 Blocks protein families:

IPB001315 CARD interaction domain

IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: NOD1_HUMAN, Q9Y239

Similarity: Contains 1 CARD domain

Similarity: Contains 9 LRR (leucine-rich) repeats

Similarity: Contains 1 NACHT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NOD1_HUMAN, Q9Y239

Function: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers

responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with

ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2

dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing

peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2

and OspB. Recruits NLRP10 to the cell membrane following bacterial infection

miRNA Products:		OriGene 3'-UTR Clone: NOD1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOD1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate NOD1:
		hsa-miR-495 hsa-miR-593* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-924 hsa-miR-605 hsa-miR-16-1*
		SwitchGear 3'UTR luciferase reporter plasmid: NOD1 3' UTR sequence

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for NOD1

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NOD1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOD1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19337385
GO:0005524	ATP binding	IEA	--
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	TAS	10329646
GO:0042802	identical protein binding	IPI	18186648
GO:0042803	protein homodimerization activity	IPI	18186648

NOD1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for NOD1: Nod1^tm1Inoh Nod1^tm1Bert
     1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Nod1):

immune system

NOD1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/19 pathways (see all 19)
TRAF6 Mediated Induction of proinflammatory cytokines	1.00	Toll Like Receptor TLR1:TLR2 Cascade	0.78
MAP kinase activation in TLR cascade	0.88	Toll Like Receptor 2 (TLR2) Cascade	0.78
Toll Like Receptor 5 (TLR5) Cascade	0.86	MyD88:Mal cascade initiated on plasma membrane	0.78
Toll Like Receptor 10 (TLR10) Cascade	0.86	TRIF-mediated TLR3/TLR4 signaling	0.73

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	1.00			activated TAK1 mediates p38 MAPK activation	0.58
	TAK1 is activated	0.60			TAK1 activates NFkB by phosphorylation and activation of IKKs complex	0.56

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	1.00			NOD-like receptor signaling pathway	0.36
	NOD1/2 Signaling Pathway	0.69			NOD pathway	0.23

Immune System

Immune System

1.00

Innate Immune System

0.46

NF-kappaB Signaling

NF-kappaB Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for NOD1

	Apoptosis and Autophagy
	NF-kappaB Signaling

1 BioSystems Pathway for NOD1

NOD pathway

5/30 Reactome Pathways for NOD1 (see all 30)

	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	Toll-Like Receptors Cascades
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

4 Kegg Pathways (Kegg details for NOD1):

	NOD-like receptor signaling pathway
	Epithelial cell signaling in Helicobacter pylori infection
	Shigellosis
	Pertussis

NOD1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NOD1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/41 Interacting proteins for NOD1 (Q9Y239^{1, 2, 3} ENSP00000222823⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RIPK2	O43353²^,³, ENSP00000220751⁴	MINT-15922 I2D: score=6 STRING: ENSP00000220751
HSPA1A	P08107²^,³	MINT-62548 I2D: score=1
HSPA1B	P08107²^,³	MINT-62548 I2D: score=1
HSP90AA1	P07900²^,³, ENSP00000335153⁴	MINT-62547 I2D: score=2 STRING: ENSP00000335153
CASP9	P55211²^,³, ENSP00000330237⁴	MINT-14299 I2D: score=4 STRING: ENSP00000330237

About this table

Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	TAS	--
GO:0002224	toll-like receptor signaling pathway	TAS	--
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	ISS	--
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	--
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS	--

NOD1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NOD1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for NOD1 available from Tocris Bioscience About this table

Compound	Action	CAS #
ML 130	Inhibits NOD1-induced NF-kappaB activation	[799264-47-4]

4 Novoseek chemical compound relationships for NOD1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fk 565	91.7	4	16637007 (1), 16299289 (1), 18231574 (1)
peptidoglycan	83.9	37	12871942 (5), 16172124 (3), 15330254 (2), 16446438 (1) (see all 21)
muramyl dipeptide	82.1	4	15617523 (1), 17100619 (1), 16299289 (1)
diaminopimelic acid	72	3	16172124 (1), 17100619 (1)

Search CenterWatch for drugs/clinical trials and news about NOD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NOD1 gene:

NM_006092.2

Unigene Cluster for NOD1:

Nucleotide-binding oligomerization domain containing 1

Hs.405153 [show with all ESTs]

Unigene Representative Sequence: NM_006092

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000222823(uc003tav.3 uc010kvs.2 uc010kvt.2 uc010kvu.2)

ENST00000434755 ENST00000489614 ENST00000467706 ENST00000413433 ENST00000411552(uc003tay.2)

ENST00000419799(uc003tax.2) ENST00000419601 ENST00000423334

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		hsa-miR-495 hsa-miR-593* hsa-miR-7-1* hsa-miR-7-2* hsa-miR-924 hsa-miR-605 hsa-miR-16-1*
		SwitchGear 3'UTR luciferase reporter plasmid: NOD1 3' UTR sequence

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Additional cDNA sequence:

AF113925.1 AF126484.1 AK300367.1 AY128682.1 AY128683.1 AY128684.1 AY128685.1 AY128686.1

AY187249.1 BC040339.1

16 DOTS entries:

DT.100760277 DT.313677 DT.100760279 DT.91676188 DT.95243302 DT.100760280 DT.100760278 DT.101983799

DT.40109209 DT.101983797 DT.101983798 DT.92000002 DT.99981798 DT.100000145 DT.121108225 DT.429111

24/116 AceView cDNA sequences (see all 116):

AI640699 AI264354 AY128684 AY128685 AI797914 AF113925 AY128686 AI246675

BC040339 AW193319 AA394280 AA845215 AA242961 AA987481 BG677151 NM_006092

AI696791 CA310179 BC020114 AK023969 BQ052832 CB045578 AA242826 BU150407

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for NOD1 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15a	·	15b
SP1:											-												-								-
SP2:											-								-												-						-
SP3:
SP4:																							-				-		-		-		-				-
SP5:																																					-

ECgene alternative splicing isoforms for NOD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NOD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGTGGGGG

About this image
See NOD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOD1

SOURCE GeneReport for Unigene cluster: Hs.405153

UniProtKB/Swiss-Prot: NOD1_HUMAN, Q9Y239

Tissue specificity: Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in

placenta, lung, liver, kidney, thymus, testis, small intestine and colon

SABiosciences Expression via Pathway-Focused PCR Arrays including NOD1 (see all 6):

Innate & Adaptive Immune Responses in human mouse rat

NFKB Signaling Pathway in human mouse rat

Inflammasomes in human mouse rat

Apoptosis 384HT in human mouse rat

Apoptosis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NOD1 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NOD1¹	nucleotide-binding oligomerization domain containing more	64.33(n) 63(a)		420677 XM_418777.2 XP_418777.2
lizard (Anolis carolinensis)	Reptilia	NOD1⁶	--	60(a)	1 ↔ 1	6(36184925-36233244)
zebrafish (Danio rerio)	Actinopterygii	nod1¹	nucleotide-binding oligomerization domain containing more	58.48(n) 51.96(a)		100330810 XM_002665060.2 XP_002665106.2

ENSEMBL Gene Tree for NOD1 (if available)
TreeFam Gene Tree for NOD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NOD1 gene

NLRC5² NOD2² CIITA²

2 SIMAP similar genes for NOD1 using alignment to 5 protein entries: NOD1_HUMAN (see all proteins):

NOD2 NOD2/CARD15

NOD1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199475901^1,2	C,	untested	30541380(-)	`AGAGCC/TTCTTT`	2	L F	mis¹		0	--	--	--	--
rs181542739^1,2		--	30463744(+)	`GATCCA/GCCACT`	1	--	ds500¹		0	--	--	--	--
rs5743378^1,2	C,H,	--	30463922(-)	`CTCCAT/CCTGGC`	1	--	ds500¹		7		NA EU NS EA	492
rs189545028^1,2		--	30464065(+)	`CTGTGA/GAGTGA`	1	--	ds500¹		0	--	--	--	--
rs200206565^1,2		--	30464208(+)	`TATCA-/CCCCCCC`	1	--	ut3¹		0	--	--	--	--
rs180732652^1,2		--	30464215(+)	`CCCCAC/TCCTCA`	1	--	ut3¹		0	--	--	--	--
rs142132816^1,2	C,	--	30464247(+)	`ATGGT-/GGGGGG`	1	--	ut3¹		0	--	--	--	--
rs145762663^1,2		--	30464566(+)	`TTAGAC/TCAGCT`	1	--	ut3¹		0	--	--	--	--
rs186461402^1,2		--	30464767(+)	`TGAGAA/GGGAAG`	1	--	ut3¹		0	--	--	--	--
rs5743374^1,2	C,F,H,	--	30464872(-)	`GTCACC/TGCTCT`	1	--	ut3¹ ese³		7		NA EU NS EA	514

HapMap Linkage Disequilibrium report for NOD1 (30464143 - 30518400 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NOD1: --
Human Gene Mutation Database (HGMD): NOD1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOD1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NOD1 for disorders           About GeneDecksing

OMIM gene information: 605980    OMIM disorders: --

20/47 diseases for NOD1 (see all 47):    About MalaCards

sclerosing cholangitis primary sclerosing cholangitis coronary heart disease inflammatory bowel disease

klebsiella cholangitis blau syndrome allergic rhinitis

atopic dermatitis duodenal ulcer chronic lymphocytic leukemia lymphocytic leukemia

ulcerative colitis lymphedema gastritis rhinitis

duodenitis cystic fibrosis shigellosis pandas

3 diseases from the University of Copenhagen DISEASES database for NOD1:

Crohn's disease Blau syndrome Ulcerative colitis

10/11 Novoseek disease relationships for NOD1 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammatory bowel diseases	62.7	7	19570976 (2), 16172124 (1), 19327158 (1), 17133080 (1) (see all 6)
colitis ulcerative	42.1	3	19723304 (2), 19327158 (1)
bacterial infections	41	3	17690884 (2), 16172124 (1)
genetic susceptibility	40.9	2	17948929 (1), 12477763 (1)
inflammation	33.3	5	17690884 (2), 18574154 (1), 20124104 (1), 16493424 (1)
colitis	23	1	19327158 (1)
gastritis	14.3	3	17309748 (3)
necrosis	0.496	4	17005562 (1), 10880512 (1), 12775719 (1), 10329646 (1)
asthma	0	3	16172124 (1), 16893397 (1), 16021603 (1)
tumors	0	8	16446438 (4), 17005562 (1), 10880512 (1), 12775719 (1) (see all 5)

Genetic Association Database (GAD): NOD1
Human Genome Epidemiology (HuGE) Navigator: NOD1 (45 documents)

Export disorders for NOD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NOD1 gene, integrated from 9 sources (see all 192):
(articles sorted by number of sources associating them with NOD1)

Utopia: connect your pdf to the dynamic
world of online information

Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor- kappaB. (PubMed id 10329646)^{1, 2, 3, 9} Inohara N.... Nunez G. (1999)
Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. (PubMed id 10224040)^{1, 2, 3} Bertin J.... DiStefano P.S. (1999)
Human Nod1 confers responsiveness to bacterial lipopolysaccharides. (PubMed id 11058605)^{1, 2, 9} Inohara N.... Nunez G. (2001)
Association of NOD1 polymorphisms with atopic eczema and related phenotypes. (PubMed id 15990792)^{1, 4, 9} Weidinger S....Illig T. (2005)
Monomer/dimer transition of the caspase-recruitment domain of human Nod1. (PubMed id 18186648)^{1, 2, 9} Srimathi T....Park Y.C. (2008)
The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. (PubMed id 17970764)^{1, 2} Kufer T.A....Sansonetti P.J. (2008)
GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors. (PubMed id 19043560)^{1, 2} Fukazawa A....Reinecker H.C. (2008)
Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. (PubMed id 17054981)^{1, 2} Manon F....Cusack S. (2007)
NOD1 variation, immunoglobulin E and asthma. (PubMed id 15718249)^{1, 4} Hysi P....Cookson W.O. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10392	HGNC: 16390	AceView: CARD4	Ensembl:ENSG00000106100	euGenes: HUgn10392
ECgene: NOD1	Kegg: 10392	H-InvDB: NOD1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NOD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NOD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NOD1 gene:
Search GeneIP for patents involving NOD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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nucleotide-binding oligomerization domain containing 1

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nucleotide-binding oligomerization domain containing 1

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