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Aliases for NOCT Gene

Aliases for NOCT Gene

  • Nocturnin 2 3 5
  • CCR4-Like (Carbon Catabolite Repression 4, S.Cerevisiae) 2 3
  • Carbon Catabolite Repression 4-Like Protein 3 4
  • Circadian Deadenylase NOC 3 4
  • CCRN4L 3 4
  • NOC 3 4
  • CCR4 Carbon Catabolite Repression 4-Like (S. Cerevisiae) 2
  • CCR4 Carbon Catabolite Repression 4-Like 3
  • CCR4 Protein Homolog 3
  • EC 3.1.13.4 4
  • CCR4L 3
  • Ccr4c 3
  • CCR4 4

External Ids for NOCT Gene

Previous HGNC Symbols for NOCT Gene

  • CCRN4L

Summaries for NOCT Gene

Entrez Gene Summary for NOCT Gene

  • The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOCT Gene

NOCT (Nocturnin) is a Protein Coding gene. Among its related pathways are Cyclins and Cell Cycle Regulation and BMAL1-CLOCK,NPAS2 activates circadian gene expression. An important paralog of this gene is PDE12.

UniProtKB/Swiss-Prot for NOCT Gene

  • Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOCT Gene

Genomics for NOCT Gene

Regulatory Elements for NOCT Gene

Enhancers for NOCT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOCT on UCSC Golden Path with GeneCards custom track

Promoters for NOCT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOCT on UCSC Golden Path with GeneCards custom track

Genomic Location for NOCT Gene

Chromosome:
4
Start:
139,015,759 bp from pter
End:
139,045,939 bp from pter
Size:
30,181 bases
Orientation:
Plus strand

Genomic View for NOCT Gene

Genes around NOCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOCT Gene

Proteins for NOCT Gene

  • Protein details for NOCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK39-NOCT_HUMAN
    Recommended name:
    Nocturnin
    Protein Accession:
    Q9UK39
    Secondary Accessions:
    • D3DNY5
    • Q14D51
    • Q9HD93
    • Q9HD94
    • Q9HD95

    Protein attributes for NOCT Gene

    Size:
    431 amino acids
    Molecular mass:
    48196 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PPARG.

neXtProt entry for NOCT Gene

Proteomics data for NOCT Gene at MOPED

Post-translational modifications for NOCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOCT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOCT Gene

Domains & Families for NOCT Gene

Protein Domains for NOCT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOCT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK39

UniProtKB/Swiss-Prot:

NOCT_HUMAN :
  • Belongs to the CCR4/nocturin family.
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with NOCT: view

No data available for Gene Families for NOCT Gene

Function for NOCT Gene

Molecular function for NOCT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function:
Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).

Enzyme Numbers (IUBMB) for NOCT Gene

Gene Ontology (GO) - Molecular Function for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with NOCT: view
genes like me logo Genes that share phenotypes with NOCT: view

Animal Models for NOCT Gene

MGI Knock Outs for NOCT:

Animal Model Products

  • Taconic Biosciences Mouse Models for NOCT

miRNA for NOCT Gene

miRTarBase miRNAs that target NOCT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOCT Gene

Localization for NOCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOCT Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region.

Gene Ontology (GO) - Cellular Components for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
genes like me logo Genes that share ontologies with NOCT: view

No data available for Subcellular locations from COMPARTMENTS for NOCT Gene

Pathways & Interactions for NOCT Gene

genes like me logo Genes that share pathways with NOCT: view

Pathways by source for NOCT Gene

1 Qiagen pathway for NOCT Gene

Interacting Proteins for NOCT Gene

Gene Ontology (GO) - Biological Process for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 10521507
GO:0007623 circadian rhythm IEA,TAS --
GO:0009991 response to extracellular stimulus IEA,ISS --
GO:0032496 response to lipopolysaccharide IEA,ISS --
genes like me logo Genes that share ontologies with NOCT: view

No data available for SIGNOR curated interactions for NOCT Gene

Drugs & Compounds for NOCT Gene

No Compound Related Data Available

Transcripts for NOCT Gene

mRNA/cDNA for NOCT Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NOCT Gene

No ASD Table

Relevant External Links for NOCT Gene

GeneLoc Exon Structure for
NOCT
ECgene alternative splicing isoforms for
NOCT

Expression for NOCT Gene

mRNA Expression by UniProt/SwissProt for NOCT Gene

Q9UK39-NOCT_HUMAN
Tissue specificity: Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NOCT Gene

Orthologs for NOCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOCT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCRN4L 35
  • 85.76 (n)
  • 91.78 (a)
CCRN4L 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCRN4L 35
  • 89.78 (n)
  • 96 (a)
CCRN4L 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccrn4l 35
  • 85.3 (n)
  • 91.27 (a)
Noct 16
Ccrn4l 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCRN4L 35
  • 99.45 (n)
  • 99.73 (a)
CCRN4L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccrn4l 35
  • 85.87 (n)
  • 90.87 (a)
oppossum
(Monodelphis domestica)
Mammalia CCRN4L 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCRN4L 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCRN4L 35
  • 76.09 (n)
  • 81.36 (a)
MNOC 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCRN4L 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccrn4l 35
  • 73.33 (n)
  • 78.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia ccrn4l-A 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13994 35
zebrafish
(Danio rerio)
Actinopterygii CCRN4L (2 of 2) 36
  • 65 (a)
OneToMany
ccrn4la 36
  • 56 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009893 35
  • 51.99 (n)
  • 46.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta cu 35
  • 53.87 (n)
  • 51.41 (a)
cu 36
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 36
  • 13 (a)
OneToMany
Species with no ortholog for NOCT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOCT Gene

ENSEMBL:
Gene Tree for NOCT (if available)
TreeFam:
Gene Tree for NOCT (if available)

Paralogs for NOCT Gene

Paralogs for NOCT Gene

Pseudogenes.org Pseudogenes for NOCT Gene

genes like me logo Genes that share paralogs with NOCT: view

Variants for NOCT Gene

Sequence variations from dbSNP and Humsavar for NOCT Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2271777 - 139,043,301(-) TGGGT(A/G)GGTAC reference, missense
rs938836 -- 139,018,499(+) TTTAT(A/G)GTACT intron-variant
rs953951 -- 139,038,719(+) CTTTT(A/C)TCATC intron-variant
rs1356461 -- 139,016,063(+) CAGGG(A/C)TGCGC reference, missense
rs1112828 -- 139,035,816(+) ATTCA(G/T)ACTGT intron-variant

Variation tolerance for NOCT Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NOCT Gene

Disorders for NOCT Gene

Relevant External Links for NOCT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOCT

No disorders were found for NOCT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOCT Gene

Publications for NOCT Gene

  1. Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion. (PMID: 10521507) Dupressoir A. … Heidmann T. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse. (PMID: 11394964) Wang Y. … Besharse J.C. (BMC Dev. Biol. 2001) 2 3 23
  3. CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter. (PMID: 18587630) Li R. … Cao J.M. (Mol. Cell. Biochem. 2008) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for NOCT Gene

Sources for NOCT Gene

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