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Aliases for NOCT Gene

Aliases for NOCT Gene

  • Nocturnin 2 3 3 5
  • CCR4-Like (Carbon Catabolite Repression 4, S.Cerevisiae) 2 3
  • Carbon Catabolite Repression 4-Like Protein 3 4
  • Circadian Deadenylase NOC 3 4
  • CCRN4L 3 4
  • NOC 3 4
  • CCR4 Carbon Catabolite Repression 4-Like (S. Cerevisiae) 2
  • CCR4 Carbon Catabolite Repression 4-Like 3
  • CCR4 Protein Homolog 3
  • EC 3.1.13.4 4
  • CCR4L 3
  • Ccr4c 3
  • CCR4 4

External Ids for NOCT Gene

Previous HGNC Symbols for NOCT Gene

  • CCRN4L

Summaries for NOCT Gene

Entrez Gene Summary for NOCT Gene

  • The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

GeneCards Summary for NOCT Gene

NOCT (Nocturnin) is a Protein Coding gene. Among its related pathways are Cyclins and Cell Cycle Regulation and Circadian rythm related genes. An important paralog of this gene is ANGEL1.

UniProtKB/Swiss-Prot for NOCT Gene

  • Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).

Additional gene information for NOCT Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOCT Gene

Genomics for NOCT Gene

Regulatory Elements for NOCT Gene

Enhancers for NOCT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H139188 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.4 +173.2 173157 1 HDAC1 YBX3 TBP HDGF PKNOX1 RB1 NFRKB NFXL1 TCF12 EGR1 NOCT PPP1R14BP3 MGARP RNU6-1074P ELF2 RAB33B RN7SL311P GC04P139201
GH04H139175 1.7 FANTOM5 ENCODE dbSUPER 13.3 +161.6 161605 3 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ELF2 NOCT NDUFC1 RAB33B GC04P139186
GH04H139081 1.6 FANTOM5 ENCODE 12.6 +68.0 67988 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ELF2 NAA15 NOCT ENSG00000273247 LOC105377448 MGARP RAB33B H3F3AP6 GC04P139099 RNU6-531P
GH04H138967 1.2 Ensembl ENCODE 10.9 -48.1 -48117 1 PKNOX1 FOXA2 ATF1 ARID4B YY1 FOS ATF7 JUNB REST PPARG LOC105377448 NOCT RAB33B ENSG00000273247 GC04P138943
GH04H139151 1.2 ENCODE dbSUPER 10.4 +138.2 138186 4 FOXA2 ATF1 TCF12 ZNF121 ZNF766 GATA2 ATF7 NCOA1 REST NFIL3 ELF2 RNU6-1074P MGARP NOCT LOC105377448 ENSG00000276396 PPP1R14BP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOCT on UCSC Golden Path with GeneCards custom track

Promoters for NOCT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000173653 741 2201 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for NOCT Gene

Chromosome:
4
Start:
139,015,759 bp from pter
End:
139,045,939 bp from pter
Size:
30,181 bases
Orientation:
Plus strand

Genomic View for NOCT Gene

Genes around NOCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOCT Gene

Proteins for NOCT Gene

  • Protein details for NOCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK39-NOCT_HUMAN
    Recommended name:
    Nocturnin
    Protein Accession:
    Q9UK39
    Secondary Accessions:
    • D3DNY5
    • Q14D51
    • Q9HD93
    • Q9HD94
    • Q9HD95

    Protein attributes for NOCT Gene

    Size:
    431 amino acids
    Molecular mass:
    48196 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PPARG.

neXtProt entry for NOCT Gene

Post-translational modifications for NOCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOCT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOCT Gene

Domains & Families for NOCT Gene

Gene Families for NOCT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NOCT Gene

Suggested Antigen Peptide Sequences for NOCT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK39

UniProtKB/Swiss-Prot:

NOCT_HUMAN :
  • Belongs to the CCR4/nocturin family.
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with NOCT: view

Function for NOCT Gene

Molecular function for NOCT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function:
Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).

Enzyme Numbers (IUBMB) for NOCT Gene

Gene Ontology (GO) - Molecular Function for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10521507
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IEA,ISS --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
genes like me logo Genes that share ontologies with NOCT: view
genes like me logo Genes that share phenotypes with NOCT: view

Animal Models for NOCT Gene

MGI Knock Outs for NOCT:

Animal Model Products

  • Taconic Biosciences Mouse Models for NOCT

CRISPR Products

miRNA for NOCT Gene

miRTarBase miRNAs that target NOCT

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NOCT
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOCT Gene

Localization for NOCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOCT Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOCT gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus TAS,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with NOCT: view

Pathways & Interactions for NOCT Gene

genes like me logo Genes that share pathways with NOCT: view

Pathways by source for NOCT Gene

1 BioSystems pathway for NOCT Gene
1 Qiagen pathway for NOCT Gene

Gene Ontology (GO) - Biological Process for NOCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10521507
GO:0006397 mRNA processing IEA --
GO:0007623 circadian rhythm TAS --
genes like me logo Genes that share ontologies with NOCT: view

No data available for SIGNOR curated interactions for NOCT Gene

Drugs & Compounds for NOCT Gene

No Compound Related Data Available

Transcripts for NOCT Gene

mRNA/cDNA for NOCT Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NOCT
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NOCT Gene

No ASD Table

Relevant External Links for NOCT Gene

GeneLoc Exon Structure for
NOCT
ECgene alternative splicing isoforms for
NOCT

Expression for NOCT Gene

NURSA nuclear receptor signaling pathways regulating expression of NOCT Gene:

NOCT

mRNA Expression by UniProt/SwissProt for NOCT Gene:

Q9UK39-NOCT_HUMAN
Tissue specificity: Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.

Evidence on tissue expression from TISSUES for NOCT Gene

  • Muscle(3.7)
  • Liver(2.3)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NOCT Gene

Orthologs for NOCT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOCT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCRN4L 34 33
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCRN4L 34 33
  • 89.78 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccrn4l 33
  • 85.87 (n)
cow
(Bos Taurus)
Mammalia CCRN4L 34 33
  • 85.76 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccrn4l 34 33
  • 85.3 (n)
OneToOne
Noct 16
oppossum
(Monodelphis domestica)
Mammalia CCRN4L 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCRN4L 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MNOC 34
  • 84 (a)
OneToOne
CCRN4L 33
  • 76.09 (n)
lizard
(Anolis carolinensis)
Reptilia CCRN4L 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccrn4l 33
  • 73.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia ccrn4l-A 33
zebrafish
(Danio rerio)
Actinopterygii CCRN4L (2 of 2) 34
  • 65 (a)
OneToMany
ccrn4la 34
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13994 33
fruit fly
(Drosophila melanogaster)
Insecta cu 34 33
  • 53.87 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009893 33
  • 51.99 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 34
  • 13 (a)
OneToMany
Species where no ortholog for NOCT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOCT Gene

ENSEMBL:
Gene Tree for NOCT (if available)
TreeFam:
Gene Tree for NOCT (if available)

Paralogs for NOCT Gene

Paralogs for NOCT Gene

Pseudogenes.org Pseudogenes for NOCT Gene

genes like me logo Genes that share paralogs with NOCT: view

Variants for NOCT Gene

Sequence variations from dbSNP and Humsavar for NOCT Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000016577 -- 139,026,721(+) AATTT(C/T)TGTAT intron-variant
rs1000030192 -- 139,033,309(+) GCAGT(A/G)AGCTG intron-variant
rs1000053783 -- 139,027,594(+) TCCCG(G/T)GTTCA intron-variant
rs1000361355 -- 139,039,335(+) CTCAC(A/G)TAAAA intron-variant
rs1000437551 -- 139,046,354(+) TATAG(C/T)ATTAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NOCT Gene

Variant ID Type Subtype PubMed ID
esv1464767 CNV deletion 17803354
esv2040934 CNV deletion 18987734
esv2544225 CNV deletion 19546169
esv2728425 CNV deletion 23290073
esv3564713 CNV deletion 23714750
esv3602431 CNV loss 21293372
nsv1073374 CNV deletion 25765185
nsv1126043 CNV deletion 24896259
nsv1151552 CNV deletion 26484159
nsv956378 CNV deletion 24416366

Variation tolerance for NOCT Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOCT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOCT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOCT Gene

Disorders for NOCT Gene

Relevant External Links for NOCT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOCT

No disorders were found for NOCT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOCT Gene

Publications for NOCT Gene

  1. Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion. (PMID: 10521507) Dupressoir A … Heidmann T (The Journal of biological chemistry 1999) 2 3 4 22 60
  2. Rhythmic expression of Nocturnin mRNA in multiple tissues of the mouse. (PMID: 11394964) Wang Y … Besharse JC (BMC developmental biology 2001) 2 3 22 60
  3. CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter. (PMID: 18587630) Li R … Cao JM (Molecular and cellular biochemistry 2008) 3 22 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for NOCT Gene

Sources for NOCT Gene

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