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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOC4L Gene

protein-coding   GIFtS: 47
GCID: GC12P132628

Nucleolar Complex Associated 4 Homolog (S. Cerevisiae)

  Search for NOC4L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nucleolar Complex Associated 4 Homolog (S. Cerevisiae)1 2     NOC42 5
Nucleolar Complex-Associated Protein 4-Like Protein2 3     NET492
NOC4 Protein Homolog2 3     UTP192
NOC4-Like Protein2 3     Nucleolar Complex Protein 4 Homolog2

External Ids:    HGNC: 284611   Entrez Gene: 790502   Ensembl: ENSG000001849677   OMIM: 6128195   UniProtKB: Q9BVI43   

Export aliases for NOC4L gene to outside databases

Previous GC identifers: GC12P131296 GC12P131194 GC12P129514


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NOC4L Gene: 
NOC4L (nucleolar complex associated 4 homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include protein binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOC4L gene promoter:
         AML1a   Brachyury   YY1   GATA-1   HEN1   PPAR-alpha   PPAR-gamma1   Ik-2   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOC4L promoter sequence
   Search SABiosciences Chromatin IP Primers for NOC4L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOC4L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

NOC4L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOC4L gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P132628:  view genomic region     (about GC identifiers)

Start:
132,628,993 bp from pter      End:
132,637,013 bp from pter
Size:
8,021 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOC4L_HUMAN, Q9BVI4 (See protein sequence)
Recommended Name: Nucleolar complex protein 4 homolog  
Size: 516 amino acids; 58468 Da
Subcellular location: Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus
Secondary accessions: Q8N2S5 Q96I14

Explore the universe of human proteins at neXtProt for NOC4L: NX_Q9BVI4

Explore proteomics data for NOC4L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BVI4

  • NOC4L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOC4L Protein Expression
    REFSEQ proteins: NP_076983.1  
    ENSEMBL proteins: 
     ENSP00000328854   ENSP00000438255   ENSP00000443336  

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    Cloud-Clone Corp. Proteins for NOC4L 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus ISS--
    GO:0016021integral to membrane IEA--
    GO:0031965nuclear membrane IEA--

    NOC4L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR027193 Noc4
     IPR005612 CCAAT-binding_factor

    Graphical View of Domain Structure for InterPro Entry Q9BVI4

    ProtoNet protein and cluster: Q9BVI4

    UniProtKB/Swiss-Prot: NOC4L_HUMAN, Q9BVI4
    Similarity: Belongs to the CBF/MAK21 family


    NOC4L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI16189514
         
    NOC4L for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NOC4L:
     Nuclear 40S maturation defects  Nucleolar pre-40S maturation d 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOC4L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/139 Interacting proteins for NOC4L (Q9BVI41, 2, 3 ENSP000003288544) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing ISS--
    GO:0042254ribosome biogenesis ----

    NOC4L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOC4L

    Search CenterWatch for drugs/clinical trials and news about NOC4L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOC4L gene: 
    NM_024078.1  

    Unigene Cluster for NOC4L:

    Nucleolar complex associated 4 homolog (S. cerevisiae)
    Hs.558536  [show with all ESTs]
    Unigene Representative Sequence: AK074489
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330579(uc001ujz.1) ENST00000541954 ENST00000535343 ENST00000538784

    miRNA
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    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AK074489.1 BC001191.1 BC007893.2 BC071958.1 

    9 DOTS entries:

    DT.211150  DT.419029  DT.100797977  DT.100030104  DT.91974860  DT.91765110  DT.97846985  DT.100030103 
    DT.91997697 

    24/208 AceView cDNA sequences (see all 208):

    BE464011 BX461428 BQ962945 BQ436998 BQ651989 BU849233 AA373830 BM557783 
    BM755812 BM809115 BC001191 BQ278824 BM820207 BM543503 BQ650257 BM772904 
    BC071958 BQ927460 AL561009 BU501827 BU839494 AI337139 BG519693 BI831735 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NOC4L    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:        -                 -                                                                                       
    SP2:                                                                          -                                       
    SP3:                                                                                                                  


    ECgene alternative splicing isoforms for NOC4L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOC4L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGAGGTCA
    NOC4L Expression
    About this image


    See NOC4L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOC4L

    SOURCE GeneReport for Unigene cluster: Hs.558536
        SABiosciences Custom PCR Arrays for NOC4L
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOC4L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOC4L gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Noc4l1 , 5 nucleolar complex associated 4 homolog (S. cerevisiae) less1, 5 79.84(n)1
    79.07(a)1
      5 (53.69 cM)5
    1006081  NM_153570.21  NP_705798.21 
     1106484185 
    chicken
    (Gallus gallus)
    Aves EP4001 E1A binding protein p400 63.88(n)
    59.05(a)
      416798  XM_003642173.1  XP_003642221.1 
    lizard
    (Anolis carolinensis)
    Reptilia NOC4L6
    nucleolar complex associated 4 homolog (S. cerevis...
    55(a)
    1 ↔ 1
    GL343364.1(220738-233520)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.339552 Xenopus laevis transcribed sequence with weak similarity to protein refNP_076983.1 (H.sapiens) hypothetical protein MGC3162 [Homo sapiens] less 73.31(n)    BQ735532.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb5342 sbcb534 71.08(n)   321293  57043197 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG28751 CG2875 46.63(n)
    32.13(a)
      31326  NM_130713.2  NP_570069.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T20B12.36
    Uncharacterized protein T20B12.3
    23(a)
    1 ↔ 1
    III(7382115-7383906)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOC4(YPR144C)4
    NOC41
    Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits less4
    Noc4p1
    43.32(n)1
    34.91(a)1
      16(821423-819765)4
    8562671, 4  NP_015470.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons EMB27621 CCAAT-binding factor 44.44(n)
    35.09(a)
      816230  NM_127279.2  NP_179316.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g05853001 hypothetical protein 45.43(n)
    37.19(a)
      4336790  NM_001060212.1  NP_001053677.1 


    ENSEMBL Gene Tree for NOC4L (if available)
    TreeFam Gene Tree for NOC4L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/416 SNPs in NOC4L are shown (see all 416)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503231321,2
    C--132630937(+) TCGTTG/TCCACC 1 -- int10--------
    rs1894568241,2
    --132630947(+) CTTTGC/GCTGTT 1 -- int10--------
    rs1380550581,2
    C--132631011(+) TGCTTC/GAATAT 1 -- int10--------
    rs1809760991,2
    --132631033(+) GGAATC/TACAAG 1 -- int10--------
    rs746608421,2
    F--132631052(+) GCAGCT/CGTGTT 1 -- int11Minor allele frequency- C:0.03EA 120
    rs1837256881,2
    --132631072(+) CTGAGA/GAACTA 1 -- int10--------
    rs1439788601,2
    --132631117(+) CCCTCC/TCCCTG 1 -- int10--------
    rs1896227041,2
    --132631149(+) CTCCAC/TATCCT 1 -- int10--------
    rs1137517611,2
    C,F--132631152(+) CACATC/TCTCGC 1 -- int12Minor allele frequency- T:0.04NA EA 122
    rs1473073621,2
    C--132631156(+) TCCTCA/GCCAAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for NOC4L (132628993 - 132637013 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/28 variations for NOC4L (see all 28):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746915CNV Deletion23290073
    esv2746916CNV Deletion23290073
    esv990728CNV Deletion20482838
    esv2670820CNV Deletion23128226
    nsv509493CNV Insertion20534489
    nsv944CNV Insertion18451855
    esv992467CNV Loss20482838
    nsv899720CNV Loss21882294
    dgv1520n71CNV Loss21882294
    dgv1524n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NOC4L for disorders           About MalaCards
    OMIM gene information: 612819    OMIM disorders: --


    NOC4L for disorders           About GeneDecksing


    Export disorders for NOC4L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOC4L gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with NOC4L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits. (PubMed id 12446671)1, 3 Milkereit P....Tschochner H. (2003)
    3. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79050 HGNC: 28461 AceView: MGC3162 Ensembl:ENSG00000184967 euGenes: HUgn79050
    ECgene: NOC4L H-InvDB: NOC4L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOC4L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOC4L gene:
    Search GeneIP for patents involving NOC4L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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