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Aliases for NOC4L Gene

Aliases for NOC4L Gene

  • Nucleolar Complex Associated 4 Homolog 2 3 5
  • Nucleolar Complex-Associated Protein 4-Like Protein 3 4
  • NOC4 Protein Homolog 3 4
  • NOC4-Like Protein 3 4
  • Nucleolar Complex Associated 4 Homolog (S. Cerevisiae) 2
  • NET49 3
  • UTP19 3
  • NOC4 3

External Ids for NOC4L Gene

Previous GeneCards Identifiers for NOC4L Gene

  • GC12P131296
  • GC12P131194
  • GC12P132628
  • GC12P129514

Summaries for NOC4L Gene

GeneCards Summary for NOC4L Gene

NOC4L (Nucleolar Complex Associated 4 Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding and binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOC4L Gene

Genomics for NOC4L Gene

Regulatory Elements for NOC4L Gene

Enhancers for NOC4L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOC4L on UCSC Golden Path with GeneCards custom track

Promoters for NOC4L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOC4L on UCSC Golden Path with GeneCards custom track

Genomic Location for NOC4L Gene

132,144,422 bp from pter
132,152,473 bp from pter
8,052 bases
Plus strand

Genomic View for NOC4L Gene

Genes around NOC4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOC4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOC4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOC4L Gene

Proteins for NOC4L Gene

  • Protein details for NOC4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar complex protein 4 homolog
    Protein Accession:
    Secondary Accessions:
    • Q8N2S5
    • Q96I14

    Protein attributes for NOC4L Gene

    516 amino acids
    Molecular mass:
    58468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NOC4L Gene

Proteomics data for NOC4L Gene at MOPED

Post-translational modifications for NOC4L Gene

  • Ubiquitination at Lys 138
  • Modification sites at PhosphoSitePlus

Other Protein References for NOC4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOC4L Gene

Domains & Families for NOC4L Gene

Protein Domains for NOC4L Gene

Suggested Antigen Peptide Sequences for NOC4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CBF/MAK21 family.
  • Belongs to the CBF/MAK21 family.
genes like me logo Genes that share domains with NOC4L: view

No data available for Gene Families for NOC4L Gene

Function for NOC4L Gene

genes like me logo Genes that share phenotypes with NOC4L: view

Animal Model Products

miRNA for NOC4L Gene

miRTarBase miRNAs that target NOC4L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOC4L Gene

Localization for NOC4L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOC4L Gene

Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for NOC4L Gene COMPARTMENTS Subcellular localization image for NOC4L gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NOC4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016021 integral component of membrane IEA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with NOC4L: view

Pathways & Interactions for NOC4L Gene

genes like me logo Genes that share pathways with NOC4L: view

Pathways by source for NOC4L Gene

Gene Ontology (GO) - Biological Process for NOC4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing ISS,TAS --
genes like me logo Genes that share ontologies with NOC4L: view

No data available for SIGNOR curated interactions for NOC4L Gene

Drugs & Compounds for NOC4L Gene

No Compound Related Data Available

Transcripts for NOC4L Gene

Unigene Clusters for NOC4L Gene

Nucleolar complex associated 4 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOC4L Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - -
SP2: -

Relevant External Links for NOC4L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOC4L Gene

mRNA expression in normal human tissues for NOC4L Gene

Protein differential expression in normal tissues from HIPED for NOC4L Gene

This gene is overexpressed in Bone (29.3) and Peripheral blood mononuclear cells (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOC4L Gene

SOURCE GeneReport for Unigene cluster for NOC4L Gene Hs.558536

genes like me logo Genes that share expression patterns with NOC4L: view

Protein tissue co-expression partners for NOC4L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOC4L Gene

Orthologs for NOC4L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOC4L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOC4L 35
  • 84.13 (n)
  • 84.62 (a)
NOC4L 36
  • 85 (a)
(Canis familiaris)
Mammalia NOC4L 35
  • 82.04 (n)
  • 81.01 (a)
NOC4L 36
  • 81 (a)
(Mus musculus)
Mammalia Noc4l 35
  • 79.84 (n)
  • 79.07 (a)
Noc4l 16
Noc4l 36
  • 79 (a)
(Pan troglodytes)
Mammalia NOC4L 35
  • 98.65 (n)
  • 97.72 (a)
(Rattus norvegicus)
Mammalia Noc4l 35
  • 79.52 (n)
  • 78.68 (a)
(Monodelphis domestica)
Mammalia NOC4L 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 50 (a)
(Gallus gallus)
Aves EP400 35
  • 63.76 (n)
  • 58.93 (a)
NOC4L 36
  • 58 (a)
(Anolis carolinensis)
Reptilia NOC4L 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3697 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33955 35
(Danio rerio)
Actinopterygii noc4l 35
  • 57.96 (n)
  • 54.03 (a)
sbcb534 35
noc4l 36
  • 53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.381 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001872 35
  • 47.44 (n)
  • 34.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2875 35
  • 46.45 (n)
  • 31.86 (a)
CG2875 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea T20B12.3 36
  • 24 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR171C 35
  • 48.38 (n)
  • 35.89 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B10890g 35
  • 49.38 (n)
  • 46.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOC4 35
  • 43.82 (n)
  • 36.13 (a)
NOC4 36
  • 28 (a)
NOC4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EMB2762 35
  • 44.16 (n)
  • 35.28 (a)
(Oryza sativa)
Liliopsida Os04g0585300 35
  • 45.91 (n)
  • 38.38 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00501 35
  • 47.97 (n)
  • 34.87 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1604.06c 35
  • 41.57 (n)
  • 36.2 (a)
Species with no ortholog for NOC4L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOC4L Gene

Gene Tree for NOC4L (if available)
Gene Tree for NOC4L (if available)

Paralogs for NOC4L Gene

No data available for Paralogs for NOC4L Gene

Variants for NOC4L Gene

Sequence variations from dbSNP and Humsavar for NOC4L Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12818246 -- 132,151,234(+) ATCCG(C/T)TGCTC intron-variant
rs7397057 -- 132,150,976(+) CTGTC(A/C/T)GCAGG intron-variant
rs79736234 -- 132,148,913(+) GCCTC(A/G)CTCAC intron-variant
rs34409120 -- 132,150,483(+) AGTGC(C/G)GCCGC intron-variant
rs7487732 -- 132,150,747(+) AGTGC(C/G)GCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOC4L Gene

Variant ID Type Subtype PubMed ID
nsv899699 CNV Gain 21882294
dgv1519n71 CNV Loss 21882294
dgv1520n71 CNV Loss 21882294
nsv899720 CNV Loss 21882294
dgv1521n71 CNV Loss 21882294
nsv428285 CNV Gain 18775914
dgv1522n71 CNV Loss 21882294
dgv1523n71 CNV Loss 21882294
dgv1524n71 CNV Loss 21882294
nsv509493 CNV Insertion 20534489
nsv470333 CNV Loss 18288195
dgv103n21 CNV Loss 19592680
nsv826563 CNV Gain 20364138
nsv899739 CNV Loss 21882294
nsv899740 CNV Loss 21882294
dgv1525n71 CNV Loss 21882294
nsv899743 CNV Loss 21882294
nsv899744 CNV Loss 21882294
nsv944 CNV Insertion 18451855
nsv899745 CNV Loss 21882294
nsv899748 CNV Gain 21882294
esv990728 CNV Deletion 20482838
esv29137 CNV Gain+Loss 19812545
nsv53069 CNV Loss 16902084
esv2746915 CNV Deletion 23290073
esv2746916 CNV Deletion 23290073
esv992467 CNV Loss 20482838
esv2670820 CNV Deletion 23128226

Variation tolerance for NOC4L Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NOC4L Gene

Disorders for NOC4L Gene

Relevant External Links for NOC4L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOC4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOC4L Gene

Publications for NOC4L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits. (PMID: 12446671) Milkereit P. … Tschochner H. (J. Biol. Chem. 2003) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for NOC4L Gene

Sources for NOC4L Gene