NOC4L Gene
protein-coding GIFtS: 47
GCID: GC12P132628
|
|
nucleolar complex associated 4 homolog (S. cerevisiae)
| |
Aliases
for NOC4L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleolar Complex Associated 4 Homolog (S. Cerevisiae)1 2 | | NOC4-Like Protein2 3 | | NET491 2 | | NOC42 5 | | UTP191 2 | | MGC31621 | | Nucleolar Complex-Associated Protein 4-Like Protein2 3 | | Nucleolar Complex Protein 4 Homolog2 | | NOC4 Protein Homolog2 3 | | |
Export aliases for NOC4L gene to outside databasesPrevious GC identifers: GC12P131296 GC12P131194 GC12P129514 |
Summaries
for NOC4L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NOC4L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009755.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOC4L gene promoter:
AML1a Brachyury YY1 GATA-1 HEN1 PPAR-alpha PPAR-gamma1 Ik-2 PPAR-gamma2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOC4L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOC4L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.33 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.33NOC4L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P132628: view genomic region
(about GC identifiers)
Start:
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132,628,993 bp from pter |
End:
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132,637,013 bp from pter |
Size:
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8,021 bases |
Orientation:
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plus strand |
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Proteins
for NOC4L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOC4L_HUMAN, Q9BVI4 (See
protein sequence)Recommended Name: Nucleolar complex protein 4 homolog Size: 516 amino acids; 58468 Da
Subcellular location: Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus
Secondary accessions: Q8N2S5 Q96I14Explore the universe of human proteins at neXtProt for NOC4L: NX_Q9BVI4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BVI4
NOC4L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076983.1
ENSEMBL proteins: ENSP00000328854 ENSP00000438255 ENSP00000443336
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NOC4L for ontologies About GeneDecksing
NOC4L Antibody Products:
Assay Products for NOC4L: |
Protein
Domains /
Families
for NOC4L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOC4L for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BVI4ProtoNet protein and cluster: Q9BVI4 UniProtKB/Swiss-Prot: NOC4L_HUMAN, Q9BVI4Similarity: Belongs to the CBF/MAK21 family |
Function
for NOC4L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOC4L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOC4L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for NOC4L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOC4L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOC4L |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
NOC4L for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for NOC4L:
|
Pathways & Interactions
for NOC4L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOC4L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/138 Interacting proteins for NOC4L (Q9BVI41, 2, 3 ENSP000003288544) via UniProtKB, MINT, STRING, and/or I2D (see all 138)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006364 | rRNA processing |
ISS | -- |
NOC4L for ontologies About GeneDecksing
|
Drugs & Compounds
for NOC4L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NOC4L
Search CenterWatch for drugs/clinical trials and news about NOC4L
|
Transcripts
for NOC4L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOC4L gene: NM_024078.1 Unigene Cluster for NOC4L: Nucleolar complex associated 4 homolog (S. cerevisiae) Hs.558536 [show with all ESTs]Unigene Representative Sequence: AK0744894 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000330579(uc001ujz.1) ENST00000541954 ENST00000535343 ENST00000538784
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOC4L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOC4L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NOC4L (NM_024078) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOC4L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOC4L |
Additional cDNA sequence: AK074489.1 BC001191.1 BC007893.2 BC071958.1 9 DOTS entries: DT.211150 DT.419029 DT.100797977 DT.100030104 DT.91974860 DT.91765110 DT.97846985 DT.100030103 DT.91997697 24/208 AceView cDNA sequences (see all 208): BM772904 BG755111 CA454206 BQ651989 BX461428 BG519693 BE464011 BM543503 BU849233 BQ941507 BC001191 BU839494 BI831735 BQ931695 BF685785 BQ645931 BQ645127 BX109260 BM755812 BM809115 BM423922 BE901312 BI755745 BU501827
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for NOC4L About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
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| SP1: | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NOC4L
|
Expression
for NOC4L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOC4L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGAGGTCA
About this image
See NOC4L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOC4L
SOURCE GeneReport for Unigene cluster: Hs.558536
SABiosciences Custom PCR Arrays for NOC4L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOC4L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOC4L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOC4L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOC4L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOC4L |
Orthologs
for NOC4L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NOC4L gene from 10/32 species (see all 32) About this table
ENSEMBL Gene Tree for NOC4L (if available)
TreeFam Gene Tree for NOC4L (if available) |
Paralogs
for NOC4L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NOC4L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NOC4L (132628993 - 132637013 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NOC4L
3 CNVs: 29932 71649 29931 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOC4L |
|
Disorders
/ Diseases
for NOC4L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 NOC4L for disorders About MalaCards
NOC4L for disorders About GeneDecksing
OMIM gene information: 612819
OMIM disorders: --
Export disorders for NOC4L gene to outside databases
|
Publications
for NOC4L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOC4L gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with NOC4L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits. (PubMed id 12446671)1, 3 Milkereit P....Tschochner H. (2003)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
|
External Searches for NOC4L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NOC4L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOC4L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOC4L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOC4L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NOC4L gene:
Search GeneIP for patents involving NOC4L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOC4L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NOC4L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOC4L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOC4L | | | OriGene Protein Over-expression Lysate for NOC4L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NOC4L | | OriGene 3'-UTR Clone for NOC4L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOC4L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOC4L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for NOC4L |
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 | | | NOC4L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOC4L |
|  |  |  | | | | ThermoFisher Antibody for NOC4L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOC4L |
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