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Aliases for NOC3L Gene

Aliases for NOC3L Gene

  • NOC3-Like DNA Replication Regulator 2 3
  • Factor For Adipocyte Differentiation 24 2 3 4
  • Nucleolar Complex-Associated Protein 3-Like Protein 3 4
  • NOC3 Protein Homolog 3 4
  • C10orf117 3 4
  • FAD24 3 4
  • AD24 3 4
  • Nucleolar Complex Associated 3 Homolog (S. Cerevisiae) 2
  • Nucleolar Complex Associated 3 Homolog 3
  • Chromosome 10 Open Reading Frame 117 2
  • NOC3L DNA Replication Regulator 3
  • NOC3-Like Protein 4

External Ids for NOC3L Gene

Previous HGNC Symbols for NOC3L Gene

  • C10orf117

Previous GeneCards Identifiers for NOC3L Gene

  • GC10M096083
  • GC10M089719

Summaries for NOC3L Gene

GeneCards Summary for NOC3L Gene

NOC3L (NOC3-Like DNA Replication Regulator) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for NOC3L Gene

  • May be required for adipogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOC3L Gene

Genomics for NOC3L Gene

Regulatory Elements for NOC3L Gene

Genomic Location for NOC3L Gene

Chromosome:
10
Start:
94,314,907 bp from pter
End:
94,362,976 bp from pter
Size:
48,070 bases
Orientation:
Minus strand

Genomic View for NOC3L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOC3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOC3L Gene

Proteins for NOC3L Gene

  • Protein details for NOC3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTT2-NOC3L_HUMAN
    Recommended name:
    Nucleolar complex protein 3 homolog
    Protein Accession:
    Q8WTT2
    Secondary Accessions:
    • Q9H5M6
    • Q9H9D8

    Protein attributes for NOC3L Gene

    Size:
    800 amino acids
    Molecular mass:
    92548 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14291.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15599.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NOC3L Gene

Proteomics data for NOC3L Gene at MOPED

Post-translational modifications for NOC3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOC3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOC3L Gene

Domains & Families for NOC3L Gene

Protein Domains for NOC3L Gene

Suggested Antigen Peptide Sequences for NOC3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WTT2

UniProtKB/Swiss-Prot:

NOC3L_HUMAN :
  • Belongs to the CBF/MAK21 family.
Family:
  • Belongs to the CBF/MAK21 family.
genes like me logo Genes that share domains with NOC3L: view

No data available for Gene Families for NOC3L Gene

Function for NOC3L Gene

Molecular function for NOC3L Gene

UniProtKB/Swiss-Prot Function:
May be required for adipogenesis.

Gene Ontology (GO) - Molecular Function for NOC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0005488 binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOC3L: view

Phenotypes for NOC3L Gene

GenomeRNAi human phenotypes for NOC3L:
genes like me logo Genes that share phenotypes with NOC3L: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOC3L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NOC3L Gene

Localization for NOC3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOC3L Gene

Nucleus, nucleolus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOC3L Gene COMPARTMENTS Subcellular localization image for NOC3L gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NOC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005730 nucleolus IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with NOC3L: view

Pathways & Interactions for NOC3L Gene

SuperPathways for NOC3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045444 fat cell differentiation IEA --
genes like me logo Genes that share ontologies with NOC3L: view

No data available for Pathways by source and SIGNOR curated interactions for NOC3L Gene

Drugs & Compounds for NOC3L Gene

No Compound Related Data Available

Transcripts for NOC3L Gene

Unigene Clusters for NOC3L Gene

Nucleolar complex associated 3 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOC3L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOC3L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1:
SP2: - -
SP3: -
SP4:

ExUns: 23
SP1:
SP2:
SP3:
SP4:

Relevant External Links for NOC3L Gene

GeneLoc Exon Structure for
NOC3L
ECgene alternative splicing isoforms for
NOC3L

Expression for NOC3L Gene

mRNA expression in normal human tissues for NOC3L Gene

Protein differential expression in normal tissues from HIPED for NOC3L Gene

This gene is overexpressed in Heart (32.9), CD8 Tcells (6.6), and Colon muscle (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOC3L Gene



SOURCE GeneReport for Unigene cluster for NOC3L Gene Hs.74899

mRNA Expression by UniProt/SwissProt for NOC3L Gene

Q8WTT2-NOC3L_HUMAN
Tissue specificity: Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus.
genes like me logo Genes that share expression patterns with NOC3L: view

Protein tissue co-expression partners for NOC3L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NOC3L Gene

Orthologs for NOC3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOC3L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOC3L 35
  • 90.14 (n)
  • 93.36 (a)
NOC3L 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOC3L 35
  • 91.23 (n)
  • 93.61 (a)
NOC3L 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Noc3l 35
  • 85.36 (n)
  • 89.84 (a)
Noc3l 16
Noc3l 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOC3L 35
  • 99.79 (n)
  • 99.62 (a)
NOC3L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Noc3l 35
  • 85.95 (n)
  • 90.84 (a)
oppossum
(Monodelphis domestica)
Mammalia NOC3L 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves NOC3L 35
  • 75.1 (n)
  • 77.82 (a)
NOC3L 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOC3L 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia noc3l 35
  • 68.99 (n)
  • 69.37 (a)
Str.1945 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16127 35
zebrafish
(Danio rerio)
Actinopterygii noc3l 35
  • 65.23 (n)
  • 67.85 (a)
noc3l 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010308 35
  • 48.19 (n)
  • 37.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1234 35
  • 48.5 (n)
  • 39.51 (a)
CG1234 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C37H5.5 35
  • 47.08 (n)
  • 35.57 (a)
C37H5.5 36
  • 30 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR032C 35
  • 44.37 (n)
  • 33.97 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09735g 35
  • 46.15 (n)
  • 32.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOC3 35
  • 46.68 (n)
  • 34.8 (a)
NOC3 36
  • 29 (a)
OneToOne
NOC3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79150 35
  • 45.33 (n)
  • 33.46 (a)
rice
(Oryza sativa)
Liliopsida Os06g0498500 35
  • 46.57 (n)
  • 32.35 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00337 35
  • 44.49 (n)
  • 34.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes noc3 35
  • 46.21 (n)
  • 32.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2414 36
  • 39 (a)
OneToOne
Species with no ortholog for NOC3L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOC3L Gene

ENSEMBL:
Gene Tree for NOC3L (if available)
TreeFam:
Gene Tree for NOC3L (if available)

Paralogs for NOC3L Gene

No data available for Paralogs for NOC3L Gene

Variants for NOC3L Gene

Sequence variations from dbSNP and Humsavar for NOC3L Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1678 -- 94,333,875(+) AAGAT(C/G)CAGTC utr-variant-3-prime, nc-transcript-variant
rs816278 -- 94,357,803(+) CCGTA(A/G)GAACT intron-variant
rs1093316 -- 94,349,017(+) TTTTT(C/T)ATTTT intron-variant
rs3052365 -- 94,348,941(-) ATATA(-/GGGTTA)TCCCA intron-variant
rs3052367 -- 94,342,554(-) TGTGT(-/GTGT)ATCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOC3L Gene

Variant ID Type Subtype PubMed ID
nsv831946 CNV Loss 17160897
esv272131 CNV Insertion 20981092
esv2480129 CNV Deletion 19546169

Variation tolerance for NOC3L Gene

Residual Variation Intolerance Score: 66.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.69; 96.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOC3L Gene

HapMap Linkage Disequilibrium report
NOC3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOC3L Gene

Disorders for NOC3L Gene

Relevant External Links for NOC3L

Genetic Association Database (GAD)
NOC3L
Human Genome Epidemiology (HuGE) Navigator
NOC3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOC3L
genes like me logo Genes that share disorders with NOC3L: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOC3L Gene

Publications for NOC3L Gene

  1. FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation. (PMID: 18520036) Johmura Y. … Imagawa M. (Biol. Pharm. Bull. 2008) 2 67
  2. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. (PMID: 15564382) Tominaga K. … Imagawa M. (J. Cell Sci. 2004) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for NOC3L Gene

Sources for NOC3L Gene

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