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Aliases for NOC3L Gene

Aliases for NOC3L Gene

  • NOC3 Like DNA Replication Regulator 2 3
  • Factor For Adipocyte Differentiation 24 2 3 4
  • NOC3-Like DNA Replication Regulator 2 3 5
  • Nucleolar Complex-Associated Protein 3-Like Protein 3 4
  • NOC3 Protein Homolog 3 4
  • C10orf117 3 4
  • FAD24 3 4
  • AD24 3 4
  • Nucleolar Complex Associated 3 Homolog (S. Cerevisiae) 2
  • Nucleolar Complex Associated 3 Homolog 3
  • Chromosome 10 Open Reading Frame 117 2
  • NOC3L DNA Replication Regulator 3
  • NOC3-Like Protein 4

External Ids for NOC3L Gene

Previous HGNC Symbols for NOC3L Gene

  • C10orf117

Previous GeneCards Identifiers for NOC3L Gene

  • GC10M096083
  • GC10M089719

Summaries for NOC3L Gene

GeneCards Summary for NOC3L Gene

NOC3L (NOC3 Like DNA Replication Regulator) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for NOC3L Gene

  • May be required for adipogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOC3L Gene

Genomics for NOC3L Gene

Regulatory Elements for NOC3L Gene

Enhancers for NOC3L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOC3L on UCSC Golden Path with GeneCards custom track

Promoters for NOC3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOC3L on UCSC Golden Path with GeneCards custom track

Genomic Location for NOC3L Gene

94,314,907 bp from pter
94,362,976 bp from pter
48,070 bases
Minus strand

Genomic View for NOC3L Gene

Genes around NOC3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOC3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOC3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOC3L Gene

Proteins for NOC3L Gene

  • Protein details for NOC3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar complex protein 3 homolog
    Protein Accession:
    Secondary Accessions:
    • Q9H5M6
    • Q9H9D8

    Protein attributes for NOC3L Gene

    800 amino acids
    Molecular mass:
    92548 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14291.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15599.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NOC3L Gene

Proteomics data for NOC3L Gene at MOPED

Post-translational modifications for NOC3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOC3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOC3L Gene

Domains & Families for NOC3L Gene

Protein Domains for NOC3L Gene

Suggested Antigen Peptide Sequences for NOC3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CBF/MAK21 family.
  • Belongs to the CBF/MAK21 family.
genes like me logo Genes that share domains with NOC3L: view

No data available for Gene Families for NOC3L Gene

Function for NOC3L Gene

Molecular function for NOC3L Gene

UniProtKB/Swiss-Prot Function:
May be required for adipogenesis.

Gene Ontology (GO) - Molecular Function for NOC3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
genes like me logo Genes that share ontologies with NOC3L: view

Phenotypes for NOC3L Gene

MGI mutant phenotypes for NOC3L:
inferred from 1 alleles
GenomeRNAi human phenotypes for NOC3L:
genes like me logo Genes that share phenotypes with NOC3L: view

Animal Models for NOC3L Gene

MGI Knock Outs for NOC3L:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOC3L Gene

Localization for NOC3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOC3L Gene

Nucleus, nucleolus. Nucleus speckle.

Subcellular locations from

Jensen Localization Image for NOC3L Gene COMPARTMENTS Subcellular localization image for NOC3L gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NOC3L Gene

Pathways & Interactions for NOC3L Gene

SuperPathways for NOC3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOC3L Gene


No data available for Pathways by source and SIGNOR curated interactions for NOC3L Gene

Drugs & Compounds for NOC3L Gene

No Compound Related Data Available

Transcripts for NOC3L Gene

Unigene Clusters for NOC3L Gene

Nucleolar complex associated 3 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOC3L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP2: - -
SP3: -

ExUns: 23

Relevant External Links for NOC3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOC3L Gene

mRNA expression in normal human tissues for NOC3L Gene

Protein differential expression in normal tissues from HIPED for NOC3L Gene

This gene is overexpressed in Heart (32.9), CD8 Tcells (6.6), and Colon muscle (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOC3L Gene

SOURCE GeneReport for Unigene cluster for NOC3L Gene Hs.74899

mRNA Expression by UniProt/SwissProt for NOC3L Gene

Tissue specificity: Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus.
genes like me logo Genes that share expression patterns with NOC3L: view

Protein tissue co-expression partners for NOC3L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NOC3L Gene

Orthologs for NOC3L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOC3L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NOC3L 35
  • 90.14 (n)
  • 93.36 (a)
NOC3L 36
  • 94 (a)
(Canis familiaris)
Mammalia NOC3L 35
  • 91.23 (n)
  • 93.61 (a)
NOC3L 36
  • 94 (a)
(Mus musculus)
Mammalia Noc3l 35
  • 85.36 (n)
  • 89.84 (a)
Noc3l 16
Noc3l 36
  • 89 (a)
(Pan troglodytes)
Mammalia NOC3L 35
  • 99.79 (n)
  • 99.62 (a)
NOC3L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Noc3l 35
  • 85.95 (n)
  • 90.84 (a)
(Monodelphis domestica)
Mammalia NOC3L 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
-- 36
  • 78 (a)
(Gallus gallus)
Aves NOC3L 35
  • 75.1 (n)
  • 77.82 (a)
NOC3L 36
  • 77 (a)
(Anolis carolinensis)
Reptilia NOC3L 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia noc3l 35
  • 68.99 (n)
  • 69.37 (a)
Str.1945 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16127 35
(Danio rerio)
Actinopterygii noc3l 35
  • 65.23 (n)
  • 67.85 (a)
noc3l 36
  • 67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010308 35
  • 48.19 (n)
  • 37.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1234 35
  • 48.5 (n)
  • 39.51 (a)
CG1234 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea C37H5.5 35
  • 47.08 (n)
  • 35.57 (a)
C37H5.5 36
  • 30 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR032C 35
  • 44.37 (n)
  • 33.97 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09735g 35
  • 46.15 (n)
  • 32.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOC3 35
  • 46.68 (n)
  • 34.8 (a)
NOC3 36
  • 29 (a)
NOC3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79150 35
  • 45.33 (n)
  • 33.46 (a)
(Oryza sativa)
Liliopsida Os06g0498500 35
  • 46.57 (n)
  • 32.35 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00337 35
  • 44.49 (n)
  • 34.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes noc3 35
  • 46.21 (n)
  • 32.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2414 36
  • 39 (a)
Species with no ortholog for NOC3L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOC3L Gene

Gene Tree for NOC3L (if available)
Gene Tree for NOC3L (if available)

Paralogs for NOC3L Gene

No data available for Paralogs for NOC3L Gene

Variants for NOC3L Gene

Sequence variations from dbSNP and Humsavar for NOC3L Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs12572897 - 94,355,078(+) GAATA(A/G)GATCT nc-transcript-variant, reference, missense
rs3758526 - 94,344,908(-) ACTAG(A/C)GCGAG nc-transcript-variant, reference, missense
rs11187895 - 94,346,483(+) TTTTT(C/G)GTTTA nc-transcript-variant, reference, missense
rs11187892 - 94,344,475(+) ATATT(A/C)TGAAG intron-variant, nc-transcript-variant, reference, missense
rs12259382 - 94,338,736(+) GAAAG(A/T)CTGCA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NOC3L Gene

Variant ID Type Subtype PubMed ID
nsv831946 CNV Loss 17160897
esv272131 CNV Insertion 20981092
esv2480129 CNV Deletion 19546169

Variation tolerance for NOC3L Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.69; 96.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NOC3L Gene

Disorders for NOC3L Gene

Relevant External Links for NOC3L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOC3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOC3L Gene

Publications for NOC3L Gene

  1. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. (PMID: 15564382) Tominaga K. … Imagawa M. (J. Cell Sci. 2004) 2 3 4 67
  2. FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation. (PMID: 18520036) Johmura Y. … Imagawa M. (Biol. Pharm. Bull. 2008) 2 3
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NOC3L Gene

Sources for NOC3L Gene