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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOC3L Gene

protein-coding   GIFtS: 46
GCID: GC10M096083

nucleolar complex associated 3 homolog (S. cerevisiae)

(Previous name: chromosome 10 open reading frame 117 )
(Previous symbol: C10orf117)
 Explore 7 diseases affiliated with
NOC3L via our new
 Human Malady Compendium 
Biological research products
for NOC3L
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nucleolar Complex Associated 3 Homolog (S. Cerevisiae)1 2     NOC3 Protein Homolog2 3
FAD241 2 3 5     NOC3-Like Protein2 3
AD241 2 3     FLJ128201
C10orf1171 2 3     Chromosome 10 Open Reading Frame 1171
Factor For Adipocyte Differentiation 242 3     Nucleolar Complex Protein 3 Homolog2
Nucleolar Complex-Associated Protein 3-Like Protein2 3     

External Ids:    HGNC: 240341   Entrez Gene: 643182   Ensembl: ENSG000001731457   OMIM: 6107695   UniProtKB: Q8WTT23   

Export aliases for NOC3L gene to outside databases

Previous GC identifer: GC10M089719


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NOC3L_HUMAN, Q8WTT2
Function: May be required for adipogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOC3L gene promoter:
         C/EBPbeta   FOXD3   Evi-1   c-Ets-1   C/EBPalpha   PPAR-gamma1   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOC3L promoter sequence
   Search SABiosciences Chromatin IP Primers for NOC3L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOC3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q23.33

NOC3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOC3L gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M096083:  view genomic region     (about GC identifiers)

Start:
96,075,004 bp from pter      End:
96,122,716 bp from pter
Size:
47,713 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NOC3L_HUMAN, Q8WTT2 (See protein sequence)
Recommended Name: Nucleolar complex protein 3 homolog  
Size: 800 amino acids; 92548 Da
Subcellular location: Nucleus, nucleolus. Nucleus speckle
Sequence caution: Sequence=BAB14291.1; Type=Erroneous initiation; Sequence=BAB15599.1; Type=Erroneous initiation;
Secondary accessions: Q9H5M6 Q9H9D8

Explore the universe of human proteins at neXtProt for NOC3L: NX_Q8WTT2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WTT2

  • NOC3L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_071896.8  
    ENSEMBL proteins: 
     ENSP00000360412   ENSP00000437838   ENSP00000360401  

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    Uscn Proteins for NOC3L

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0016607nuclear speck IEA--


    NOC3L for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NOC3L


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NOC3L for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016903 Nucleolar_cplx-assoc_3
     IPR011501 NOC3p
     IPR005612 CCAAT-binding_factor

    Graphical View of Domain Structure for InterPro Entry Q8WTT2

    ProtoNet protein and cluster: Q8WTT2

    UniProtKB/Swiss-Prot: NOC3L_HUMAN, Q8WTT2
    Similarity: Belongs to the CBF/MAK21 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NOC3L_HUMAN, Q8WTT2
    Function: May be required for adipogenesis (By similarity)

    miRNA
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    hsa-miR-877* hsa-miR-3163 hsa-miR-300 hsa-miR-381 hsa-miR-181a-2* hsa-miR-643
    SwitchGear 3'UTR luciferase reporter plasmidNOC3L 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOC3L


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOC3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/123 Interacting proteins for NOC3L (Q8WTT23 ENSP000003604124) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045444fat cell differentiation IEA--


    NOC3L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOC3L
    Search CenterWatch for drugs/clinical trials and news about NOC3L 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOC3L gene: 
    NM_022451.9  

    Unigene Cluster for NOC3L:

    Nucleolar complex associated 3 homolog (S. cerevisiae)
    Hs.74899  [show with all ESTs]
    Unigene Representative Sequence: BC049850
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371361(uc001kjq.1) ENST00000463649(uc009xuk.1) ENST00000461562
    ENST00000543788 ENST00000371350

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate NOC3L:
    hsa-miR-877* hsa-miR-3163 hsa-miR-300 hsa-miR-381 hsa-miR-181a-2* hsa-miR-643
    SwitchGear 3'UTR luciferase reporter plasmidNOC3L 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOC3L (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AB077992.1 AK022882.1 AK026953.1 AK091246.1 AK292520.1 AK302028.1 BC030999.1 BC049850.1 

    6 DOTS entries:

    DT.440959  DT.92037158  DT.102823277  DT.100660410  DT.121256662  DT.101965210 

    24/106 AceView cDNA sequences (see all 106):

    BU617813 CK903076 CB321655 CA430722 AK026953 BM458241 AA131345 BQ773252 
    AB077992 AI745595 BC030999 BM802539 NM_022451 AI632144 BQ011935 CA309428 
    CA866815 AA316901 BU622598 BU195307 BC049850 AA761217 AI092233 AK022882 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NOC3L    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                            
    SP2:                          -     -                                                                                                                           
    SP3:                          -                                                                                                                                 
    SP4:                                                                                                                                                            

    ExUns: 23
    SP1:      
    SP2:      
    SP3:      
    SP4:      


    ECgene alternative splicing isoforms for NOC3L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOC3L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAGACATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NOC3L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOC3L

    SOURCE GeneReport for Unigene cluster: Hs.74899

    UniProtKB/Swiss-Prot: NOC3L_HUMAN, Q8WTT2
    Tissue specificity: Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen
    and thymus

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOC3L gene from 10/32 species (see all 32)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Noc3l1 , 5 nucleolar complex associated 3 homolog (S. cerevisiae) less1, 5 86.07(n)1
    90.72(a)1
      19 (33.42 cM)5
    577531  NM_021315.21  NP_067290.21 
     387881285 
    chicken
    (Gallus gallus)
    Aves NOC3L1 nucleolar complex associated 3 homolog (S. cerevisiae) less 75.05(n)
    77.86(a)
      423799  XM_421670.3  XP_421670.3 
    lizard
    (Anolis carolinensis)
    Reptilia NOC3L6
    --
    77(a)
    1 ↔ 1
    GL343219.1(1308581-1330840)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161272 Xenopus laevis transcribed sequence with weak similarity to protein refNP_071896.2 (H.sapiens) AD24 protein [Homo sapiens] less 75.69(n)    BU908205.1 
    zebrafish
    (Danio rerio)
    Actinopterygii noc3l1 nucleolar complex associated 3 homolog (S. cerevisiae) less 65.52(n)
    68.28(a)
      321289  NM_001002863.1  NP_001002863.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG12341 CG1234 47.2(n)
    37.2(a)
      40870  NM_141453.4  NP_649710.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C37H5.51 Protein C37H5.5 46.22(n)
    34.56(a)
      178874  NM_071891.4  NP_504292.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOC3(YLR002C)4
    NOC31
    Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation less4
    Noc3p1
    45.13(n)1
    32.92(a)1
      12(156334-154343)4
    8506881, 4  NP_013102.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G791501 nucleolar complex-associated protein domain-containing protein less 45.77(n)
    32.27(a)
      844256  NM_106566.3  NP_178036.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g04985001 hypothetical protein 44.15(n)
    30.92(a)
      4341106  NM_001064235.1  NP_001057700.1 


    ENSEMBL Gene Tree for NOC3L (if available)
    TreeFam Gene Tree for NOC3L (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/592 NCBI SNPs in NOC3L are shown (see all 592    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733218571,2
    C,--96092511(+) GTATAG/ATTTCT 1 -- int12Minor allele frequency- A:0.11WA 120
    rs1495805171,2
    --96092584(+) TATTGA/GTCACT 1 -- int10--------
    rs1885734831,2
    --96092587(+) TGGTCA/CCTTGT 1 -- int10--------
    rs791303191,2
    C,F,--96092595(+) TGTGCT/CCTGAT 1 -- int13Minor allele frequency- C:0.05WA NA EA 358
    rs127814811,2
    C,F,H,--96092642(+) ATCACA/TTTCCT 1 -- int115Minor allele frequency- T:0.11NA NS EA WA 932
    rs618863451,2
    C,--96092854(+) TTTCGT/CTNNNN 1 -- int12Minor allele frequency- C:0.11NA 122
    rs1160405441,2
    F,--96092881(+) CTCTAA/CGCTCC 1 -- int11Minor allele frequency- C:0.04WA 118
    rs1457079161,2
    C,--96092991(+) AGCAG-/AAAAAA 1 -- ut310--------
    rs1816475951,2
    --96093026(+) CACAAC/TAGAGA 1 -- ut310--------
    rs782526711,2
    C,F,--96093175(+) TCCTCA/GTTGAG 1 -- ut311Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for NOC3L (96075004 - 96122716 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NOC3L
         1 CNV: 101016

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOC3L
    DNA2.0 Custom Variant and Variant Library Synthesis for NOC3L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NOC3L for disorders           About GeneDecksing

    OMIM gene information: 610769    OMIM disorders: --

    7 diseases for NOC3L:    About MalaCards
    esophageal squamous cell carcinoma    squamous cell carcinoma    brucellosis    alzheimer's disease
    esophagitis    carcinoma    adenocarcinoma

    Human Genome Epidemiology (HuGE) Navigator: NOC3L (1 document)

    Export disorders for NOC3L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOC3L gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with NOC3L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. (PubMed id 15564382)1, 2, 3 Tominaga K.... Imagawa M. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    6. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)
    7. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    8. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64318 HGNC: 24034 AceView: C10orf117 Ensembl:ENSG00000173145 euGenes: HUgn64318
    ECgene: NOC3L H-InvDB: NOC3L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOC3L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for NOC3L gene:
    Search GeneIP for patents involving NOC3L

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