NOC3L Gene
protein-coding GIFtS: 46
GCID: GC10M096083
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nucleolar complex associated 3 homolog (S. cerevisiae)(Previous name: chromosome 10 open reading frame 117 )
(Previous symbol: C10orf117)
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Aliases
for NOC3L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleolar Complex Associated 3 Homolog (S. Cerevisiae)1 2 | | NOC3 Protein Homolog2 3 | | FAD241 2 3 5 | | NOC3-Like Protein2 3 | | AD241 2 3 | | FLJ128201 | | C10orf1171 2 3 | | Chromosome 10 Open Reading Frame 1171 | | Factor For Adipocyte Differentiation 242 3 | | Nucleolar Complex Protein 3 Homolog2 | | Nucleolar Complex-Associated Protein 3-Like Protein2 3 | | |
Export aliases for NOC3L gene to outside databasesPrevious GC identifer: GC10M089719 |
Summaries
for NOC3L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NOC3L_HUMAN, Q8WTT2Function: May be required for adipogenesis (By similarity)
|
Genomic Views
for NOC3L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOC3L gene promoter:
C/EBPbeta FOXD3 Evi-1 c-Ets-1 C/EBPalpha PPAR-gamma1 FOXO1a PPAR-gamma2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOC3L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOC3L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.33 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q23.33NOC3L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M096083: view genomic region
(about GC identifiers)
Start:
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96,075,004 bp from pter |
End:
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96,122,716 bp from pter |
Size:
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47,713 bases |
Orientation:
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minus strand |
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Proteins
for NOC3L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NOC3L_HUMAN, Q8WTT2 (See
protein sequence)Recommended Name: Nucleolar complex protein 3 homolog Size: 800 amino acids; 92548 Da
Subcellular location: Nucleus, nucleolus. Nucleus speckle
Sequence caution: Sequence=BAB14291.1; Type=Erroneous initiation; Sequence=BAB15599.1; Type=Erroneous initiation;
Secondary accessions: Q9H5M6 Q9H9D8Explore the universe of human proteins at neXtProt for NOC3L: NX_Q8WTT2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WTT2
NOC3L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071896.8
ENSEMBL proteins: ENSP00000360412 ENSP00000437838 ENSP00000360401
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NOC3L for ontologies About GeneDecksing
NOC3L Antibody Products:
Assay Products for NOC3L: |
Protein
Domains /
Families
for NOC3L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOC3L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WTT2ProtoNet protein and cluster: Q8WTT2 UniProtKB/Swiss-Prot: NOC3L_HUMAN, Q8WTT2Similarity: Belongs to the CBF/MAK21 family |
Function
for NOC3L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NOC3L_HUMAN, Q8WTT2Function: May be required for adipogenesis (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOC3L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOC3L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NOC3L (NM_022451) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOC3L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOC3L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOC3L |
|
Pathways & Interactions
for NOC3L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOC3L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/123 Interacting proteins for NOC3L (Q8WTT23 ENSP000003604124) via UniProtKB, MINT, STRING, and/or I2D (see all 123)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045444 | fat cell differentiation |
IEA | -- |
NOC3L for ontologies About GeneDecksing
|
Drugs & Compounds
for NOC3L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NOC3L
Search CenterWatch for drugs/clinical trials and news about NOC3L
|
Transcripts
for NOC3L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NOC3L gene: NM_022451.9 Unigene Cluster for NOC3L: Nucleolar complex associated 3 homolog (S. cerevisiae) Hs.74899 [show with all ESTs]Unigene Representative Sequence: BC0498505 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371361(uc001kjq.1) ENST00000463649(uc009xuk.1) ENST00000461562
ENST00000543788 ENST00000371350
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOC3L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOC3L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NOC3L (NM_022451) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NOC3L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOC3L |
Additional cDNA sequence: AB077992.1 AK022882.1 AK026953.1 AK091246.1 AK292520.1 AK302028.1 BC030999.1 BC049850.1 6 DOTS entries: DT.440959 DT.92037158 DT.102823277 DT.100660410 DT.121256662 DT.101965210 24/106 AceView cDNA sequences (see all 106): BU617813 CK903076 CB321655 CA430722 AK026953 BM458241 AA131345 BQ773252 AB077992 AI745595 BC030999 BM802539 NM_022451 AI632144 BQ011935 CA309428 CA866815 AA316901 BU622598 BU195307 BC049850 AA761217 AI092233 AK022882
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NOC3L About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 23 |
|---|
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| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | |
ECgene alternative splicing isoforms for NOC3L
|
Expression
for NOC3L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NOC3L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGACATT
About this image
See NOC3L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOC3L
SOURCE GeneReport for Unigene cluster: Hs.74899
UniProtKB/Swiss-Prot: NOC3L_HUMAN, Q8WTT2Tissue specificity: Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleenand thymus
SABiosciences Custom PCR Arrays for NOC3L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOC3L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOC3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOC3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOC3L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOC3L |
Orthologs
for NOC3L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NOC3L gene from 10/32 species (see all 32) About this table
ENSEMBL Gene Tree for NOC3L (if available)
TreeFam Gene Tree for NOC3L (if available) |
Paralogs
for NOC3L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NOC3L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NOC3L (96075004 - 96122716 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NOC3L
1 CNV: 101016 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOC3L |
|
Disorders
/ Diseases
for NOC3L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NOC3L for disorders About GeneDecksing
OMIM gene information: 610769
OMIM disorders: --
7  diseases for NOC3L: About MalaCardsesophageal squamous cell carcinoma squamous cell carcinoma brucellosis alzheimer's disease
esophagitis carcinoma adenocarcinoma
Human Genome Epidemiology (HuGE) Navigator: NOC3L (1 document)
Export disorders for NOC3L gene to outside databases
|
Publications
for NOC3L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NOC3L gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with NOC3L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. (PubMed id 15564382)1, 2, 3 Tominaga K.... Imagawa M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
|
External Searches for NOC3L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NOC3L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOC3L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOC3L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NOC3L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NOC3L gene:
Search GeneIP for patents involving NOC3L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOC3L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NOC3L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOC3L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOC3L | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NOC3L | | OriGene 3'-UTR Clone for NOC3L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOC3L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOC3L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NOC3L | | OriGene Custom Protein Services for NOC3L | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOC3L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOC3L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOC3L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOC3L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOC3L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOC3L |
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| | | | Search Tocris compounds for NOC3L |
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 | | | NOC3L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOC3L |
|  |  |  | | | | Search ThermoFisher Antibodies for NOC3L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOC3L |
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