Aliases for NOC2L Gene
- NOC2 Like Nucleolar Associated Transcriptional Repressor 2 3 5
- Novel INHAT Repressor 2 3 4
- Protein Phosphatase 1, Regulatory Subunit 12 2 3
- Protein NOC2 Homolog 3 4
- NOC2-Like Protein 3 4
- NIR 3 4
- Novel INHAT (Inhibitor Of Histone Acetyltransferase) Repressor 3
- Nucleolar Complex Associated 2 Homolog (S. Cerevisiae) 2
External Ids for NOC2L Gene
Previous GeneCards Identifiers for NOC2L Gene
Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NOC2L Gene
NOC2L (NOC2 Like Nucleolar Associated Transcriptional Repressor) is a Protein Coding gene. Diseases associated with NOC2L include Corneal Dystrophy, Posterior Amorphous and Retinitis Pigmentosa, Y-Linked. Among its related pathways are Regulation of TP53 Activity and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and binding.
UniProtKB/Swiss-Prot for NOC2L Gene
Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.