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NOC2L Gene

protein-coding   GIFtS: 53
GCID: GC01M000879

Nucleolar Complex Associated 2 Homolog (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nucleolar Complex Associated 2 Homolog (S. Cerevisiae)1 2     NET152
Novel INHAT Repressor1 2 3     NET72
NIR2 3 5     Novel INHAT (Inhibitor Of Histone Acetyltransferase) Repressor2
Protein NOC2 Homolog2 3     Nucleolar Complex Protein 2 Homolog2
NOC2-Like Protein2 3     

External Ids:    HGNC: 245171   Entrez Gene: 261552   Ensembl: ENSG000001889767   OMIM: 6107705   UniProtKB: Q9Y3T93   
ORGUL members:         

Export aliases for NOC2L gene to outside databases

Previous GC identifers: GC01M000920 GC01M000869 GC01M000151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOC2L Gene:
Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects
of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase
(INHAT) (Hublitz et al., 2005 (PubMed 16322561)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NOC2L Gene:
NOC2L (nucleolar complex associated 2 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with NOC2L include retinal degeneration, and colon adenocarcinoma. GO annotations related to this gene include chromatin binding and histone binding.

UniProtKB/Swiss-Prot: NOC2L_HUMAN, Q9Y3T9
Function: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by
the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases
(HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of
the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with
TP63 isoform TA*-gamma to the p21/CDKN1A promoter

Gene Wiki entry for NOC2L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOC2L gene promoter:
         CREB   Max   Max1   deltaCREB   XBP-1   YY1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOC2L promoter sequence
   Search Chromatin IP Primers for NOC2L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOC2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

NOC2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOC2L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M000879:  view genomic region     (about GC identifiers)

Start:
879,583 bp from pter      End:
894,689 bp from pter
Size:
15,107 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NOC2L_HUMAN, Q9Y3T9 (See protein sequence)
Recommended Name: Nucleolar complex protein 2 homolog  
Size: 749 amino acids; 84919 Da
Subunit: Interacts with p53/TP53. Interacts (via the N- and C-terminus domains) with AURKB (via the middle kinase
domain). Interacts with TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3 (via N-terminus
and non-acetylated form preferentially). Associates with core histones and nucleosomes
Secondary accessions: Q5SVA3 Q9BTN6

Explore the universe of human proteins at neXtProt for NOC2L: NX_Q9Y3T9

Explore proteomics data for NOC2L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys168, Lys516, Lys606, Lys637
  • Modification sites at PhosphoSitePlus

  • See NOC2L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056473.2  
    ENSEMBL proteins: 
     ENSP00000317992  

    NOC2L Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR005343 Noc2
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9Y3T9

    ProtoNet protein and cluster: Q9Y3T9

    1 Blocks protein domain: IPB005343 Protein of unknown function UPF0120

    UniProtKB/Swiss-Prot: NOC2L_HUMAN, Q9Y3T9
    Similarity: Belongs to the NOC2 family


    NOC2L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOC2L_HUMAN, Q9Y3T9
    Function: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by
    the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases
    (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of
    the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with
    TP63 isoform TA*-gamma to the p21/CDKN1A promoter
    Induction: Up-regulated by IL4 and CD40L in B-cells

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA16322561
    GO:0003714transcription corepressor activity IDA16322561
    GO:0005488binding ----
    GO:0005515protein binding IPI16322561
    GO:0031491nucleosome binding IDA16322561
         
    NOC2L for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NOC2L:
     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOC2L
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOC2L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOC2L

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOC2L:
    hsa-mir-484 (MIRT042192), hsa-mir-17-5p (MIRT050868), hsa-mir-1 (MIRT023960), hsa-mir-615-3p (MIRT040269), hsa-mir-92a-3p (MIRT049204), hsa-mir-149-5p (MIRT045456)

    Block miRNA regulation of human, mouse, rat NOC2L using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NOC2L:
    hsa-miR-3164
    SwitchGear 3'UTR luciferase reporter plasmidNOC2L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOC2L
    Predesigned siRNA for gene silencing in human, mouse, rat NOC2L

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NOC2L (NM_015658)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOC2L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOC2L_HUMAN, Q9Y3T9: Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the
    nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly
    detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    chloroplast1
    cytosol1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA--
    GO:0005730nucleolus IDA--

    NOC2L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOC2L
    Interactions:

        Search GeneGlobe Interaction Network for NOC2L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOC2L (Q9Y3T91, 2, 3 ENSP000003179924) via UniProtKB, MINT, STRING, and/or I2D (see all 294)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 3, ENSP000002693054EBI-751547,EBI-366083 I2D: score=1 STRING: ENSP00000269305
    ATXN7O152651, 3EBI-751547,EBI-708350 I2D: score=1 
    ENSG00000204221O152133I2D: score=1 
    ENSG00000206284O152133I2D: score=1 
    ENSG00000226916O152133I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0002903negative regulation of B cell apoptotic process IMP--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006915apoptotic process IEA--
    GO:0031497chromatin assembly IDA16322561

    NOC2L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOC2L

    6 Novoseek inferred chemical compound relationships for NOC2L gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dithionite 71.3 1 12082116 (1)
    methyl viologen 68.5 6 16713751 (4), 11139389 (1)
    copper 53.5 7 18830721 (2), 9647763 (1), 17701241 (1), 16613859 (1) (see all 5)
    nitrate 50.3 5 18471094 (2), 17688585 (1), 9014362 (1), 12232660 (1)
    nitric oxide 2.99 9 16164557 (4), 15221185 (1)
    carbon 0 1 16713751 (1)



    NOC2L for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NOC2L gene: 
    NM_015658.3  

    Unigene Cluster for NOC2L:

    Nucleolar complex associated 2 homolog (S. cerevisiae)
    Hs.405987  [show with all ESTs]
    Unigene Representative Sequence: NM_015658
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483767 ENST00000327044(uc001abz.4 uc009vjq.3) ENST00000477976(uc001aby.4)
    ENST00000496938 ENST00000487214 ENST00000469563(uc009vjr.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NOC2L using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NOC2L:
    hsa-miR-3164
    SwitchGear 3'UTR luciferase reporter plasmidNOC2L 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NOC2L
    Predesigned siRNA for gene silencing in human, mouse, rat NOC2L
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    GenScript: all cDNA clones in your preferred vector: NOC2L (NM_015658)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NOC2L
      QuantiTect SYBR Green Assays in human, mouse, rat NOC2L
      QuantiFast Probe-based Assays in human, mouse, rat NOC2L

    Additional mRNA sequence: 

    AK022756.1 AK024284.1 AK225239.1 AK315080.1 AL050019.1 BC003555.1 

    Selected DOTS entries (see all 27):

    DT.431656  DT.92449043  DT.97786998  DT.100812602  DT.95270931  DT.100812599  DT.40260719  DT.100812605 
    DT.101972658  DT.95270932  DT.100030898  DT.92040183  DT.100812601  DT.100835152  DT.100057140  DT.100658051 
    DT.100812603  DT.121329401  DT.121329423  DT.121329506  DT.121329526  DT.40125956  DT.92040185  DT.95270933 

    Selected AceView cDNA sequences (see all 482):

    BQ071762 BM793023 BX645732 BI258705 BM458407 BM824125 BM826113 CK430372 
    BQ063768 BQ926801 BM561367 BM467569 AW375314 BU517259 BU620276 BU846162 
    BE795961 BQ226740 AV654762 BM826104 BM475220 BM834908 AL047455 BQ927827 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOC2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGACCAAA
    NOC2L Expression
    About this image

    NOC2L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOC2L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405987
        Custom PCR Arrays for NOC2L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOC2L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NOC2L gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Noc2l1 , 5 nucleolar complex associated 2 homolog (S. cerevisiae)1, 5 77.39(n)1
    75.64(a)1
      45
    577411  NM_021303.21  NP_067278.21 
     1562360105 
    chicken
    (Gallus gallus)
    Aves NOC2L1 nucleolar complex associated 2 homolog (S. cerevisiae) 67.03(n)
    64.66(a)
      419433  NM_001030876.1  NP_001026047.1 
    lizard
    (Anolis carolinensis)
    Reptilia NOC2L6
    nucleolar complex associated 2 homolog (S. cerevis...
    63(a)
    1 ↔ 1
    GL344314.1(7700-51235)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59052 Xenopus laevis transcribed sequence with weak similarity more 72.87(n)    AW645690.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd51102 idibd5110 76.4(n)   58013  BM264897.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92461 CG9246 50.55(n)
    39.24(a)
      35386  NM_136251.3  NP_610095.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pro-21 pro-2 39.75(n)
    29.42(a)
      174598  NM_063823.3  NP_496224.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOC2(YOR206W)4
    NOC21
    Protein that forms a nucleolar complex with Mak21p more4
    NOC21
    41.46(n)1
    33.71(a)1
      15(727512-729644)4
    8543811, 4  NP_014849.31  NP_014849.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G182201 AT2G18220 43.44(n)
    29.6(a)
      816337  NM_127379.2  NP_179414.2 
    rice
    (Oryza sativa)
    Liliopsida Os10g04955001 Os10g0495500 44.31(n)
    33.53(a)
      4349000  NM_001071486.2  NP_001064951.2 


    ENSEMBL Gene Tree for NOC2L (if available)
    TreeFam Gene Tree for NOC2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOC2L gene

    NOC2L for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NOC2L
    PGOHUM00000240328 PGOHUM00000240915


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOC2L (see all 643)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386520361,2
    C--880466(+) CGCCCT/CCCTCC 2 /E /G mis11Minor allele frequency- C:0.00NA 4476
    rs1446562661,2
    C,F--880483(+) TCTTCA/GTCGTC 2 D syn11Minor allele frequency- G:0.00NA 4444
    rs740474181,2
    C,F--880502(+) CATGCC/TGAGTG 2 Q R mis12Minor allele frequency- T:0.00WA NA 4352
    rs1409018091,2
    F--880503(+) ATGCCG/AAGTGC 2 /R /W mis11Minor allele frequency- A:0.00NA 4326
    rs359165041,2
    C--880640(-) TGCTGG/-AAGTC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1468576361,2
    --880647(+) AGCAGA/GTGGAG 1 -- int10--------
    rs1931048581,2
    C--880679(+) GGAGGC/TCACAG 1 -- int10--------
    rs1135634661,2
    C,F--880751(+) CCAGAA/GGCCTG 1 -- int12Minor allele frequency- G:0.12CSA WA 120
    rs2005153861,2
    --880848(+) TCCAGA/CAGAGC 1 -- int10--------
    rs1999689831,2
    --880865(+) GGCCCA/GCCCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for NOC2L (879583 - 894689 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NOC2L (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509035CNV Insertion20534489
    dgv8n71CNV Loss21882294
    dgv9n71CNV Loss21882294
    dgv10n71CNV Loss21882294
    nsv870660CNV Loss21882294
    dgv11n71CNV Loss21882294
    nsv871547CNV Loss21882294
    nsv428334CNV Gain18775914
    nsv832980CNV Gain17160897
    dgv2n67CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610770    OMIM disorders: --

    6 diseases for NOC2L:    
    About MalaCards
    retinal degeneration    colon adenocarcinoma    retinitis    ataxia
    adenocarcinoma    malaria


    NOC2L for disorders           About GeneDecksing


    Export disorders for NOC2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOC2L gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with NOC2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. (PubMed id 16322561)1, 2, 9 Hublitz P.... Schule R. (Genes Dev. 2005)
    2. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. (PubMed id 20959462)1, 2 Wu L.... Jain A. (J. Biol. Chem. 2011)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins. (PubMed id 23537643)1 Liang C....Zhang L. (Biochem. Biophys. Res. Commun. 2013)
    9. Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits. (PubMed id 22363708)1 Wu J....Ke Y. (PLoS ONE 2012)
    10. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26155 HGNC: 24517 AceView: DKFZP564C186 Ensembl:ENSG00000188976 euGenes: HUgn26155
    ECgene: NOC2L H-InvDB: NOC2L

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NOC2L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NOC2L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NOC2L gene:
    Search GeneIP for patents involving NOC2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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