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Aliases for NOC2L Gene

Aliases for NOC2L Gene

  • NOC2 Like Nucleolar Associated Transcriptional Repressor 2 3 5
  • Novel INHAT Repressor 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 12 2 3
  • Protein NOC2 Homolog 3 4
  • NOC2-Like Protein 3 4
  • NIR 3 4
  • Novel INHAT (Inhibitor Of Histone Acetyltransferase) Repressor 3
  • Nucleolar Complex Associated 2 Homolog (S. Cerevisiae) 2
  • NOC2L Nucleolar Associated Transcriptional Repressor 3
  • Nucleolar Complex Associated 2 Homolog 3
  • Nucleolar Complex Protein 2 Homolog 3
  • PPP1R112 3
  • NET15 3
  • NET7 3

External Ids for NOC2L Gene

Previous GeneCards Identifiers for NOC2L Gene

  • GC01M000920
  • GC01M000869
  • GC01M000879
  • GC01M000151

Summaries for NOC2L Gene

Entrez Gene Summary for NOC2L Gene

  • Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NOC2L Gene

NOC2L (NOC2 Like Nucleolar Associated Transcriptional Repressor) is a Protein Coding gene. Diseases associated with NOC2L include Corneal Dystrophy, Posterior Amorphous. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include poly(A) RNA binding and binding.

UniProtKB/Swiss-Prot for NOC2L Gene

  • Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.

Gene Wiki entry for NOC2L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOC2L Gene

Genomics for NOC2L Gene

Regulatory Elements for NOC2L Gene


Enhancers around NOC2L on UCSC Golden Path with GeneCards custom track

Promoters for NOC2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000528861 -491 3601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF143 SP3 SP5

Genomic Location for NOC2L Gene

Chromosome:
1
Start:
944,203 bp from pter
End:
959,309 bp from pter
Size:
15,107 bases
Orientation:
Minus strand

Genomic View for NOC2L Gene

Genes around NOC2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOC2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOC2L Gene

Proteins for NOC2L Gene

  • Protein details for NOC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3T9-NOC2L_HUMAN
    Recommended name:
    Nucleolar complex protein 2 homolog
    Protein Accession:
    Q9Y3T9
    Secondary Accessions:
    • Q5SVA3
    • Q9BTN6

    Protein attributes for NOC2L Gene

    Size:
    749 amino acids
    Molecular mass:
    84919 Da
    Quaternary structure:
    • Interacts with p53/TP53. Interacts (via the N- and C-terminus domains) with AURKB (via the middle kinase domain). Interacts with TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3 (via N-terminus and non-acetylated form preferentially). Associates with core histones and nucleosomes.

neXtProt entry for NOC2L Gene

Post-translational modifications for NOC2L Gene

  • Ubiquitination at Lys 168, Lys 516, Lys 606, and Lys 637
  • Modification sites at PhosphoSitePlus

Other Protein References for NOC2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOC2L Gene

Domains & Families for NOC2L Gene

Gene Families for NOC2L Gene

Protein Domains for NOC2L Gene

Suggested Antigen Peptide Sequences for NOC2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3T9

UniProtKB/Swiss-Prot:

NOC2L_HUMAN :
  • Belongs to the NOC2 family.
Family:
  • Belongs to the NOC2 family.
genes like me logo Genes that share domains with NOC2L: view

Function for NOC2L Gene

Molecular function for NOC2L Gene

UniProtKB/Swiss-Prot Function:
Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL4 and CD40L in B-cells.

Gene Ontology (GO) - Molecular Function for NOC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 16322561
GO:0003714 transcription corepressor activity IDA 16322561
GO:0005515 protein binding IPI 16322561
GO:0031491 nucleosome binding IDA 16322561
GO:0042393 histone binding IDA 16322561
genes like me logo Genes that share ontologies with NOC2L: view
genes like me logo Genes that share phenotypes with NOC2L: view

Animal Models for NOC2L Gene

MGI Knock Outs for NOC2L:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOC2L Gene

Localization for NOC2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOC2L Gene

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOC2L Gene COMPARTMENTS Subcellular localization image for NOC2L gene
Compartment Confidence
nucleus 5
chloroplast 2
mitochondrion 2
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NOC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16322561
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA 20123734
GO:0005737 cytoplasm IDA --
GO:0030690 Noc1p-Noc2p complex IBA --
genes like me logo Genes that share ontologies with NOC2L: view

Pathways & Interactions for NOC2L Gene

genes like me logo Genes that share pathways with NOC2L: view

Gene Ontology (GO) - Biological Process for NOC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20123734
GO:0002903 negative regulation of B cell apoptotic process IMP 20959462
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with NOC2L: view

No data available for SIGNOR curated interactions for NOC2L Gene

Drugs & Compounds for NOC2L Gene

(2) Drugs for NOC2L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for NOC2L Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NOC2L: view

Transcripts for NOC2L Gene

Unigene Clusters for NOC2L Gene

Nucleolar complex associated 2 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOC2L Gene

No ASD Table

Relevant External Links for NOC2L Gene

GeneLoc Exon Structure for
NOC2L
ECgene alternative splicing isoforms for
NOC2L

Expression for NOC2L Gene

mRNA expression in normal human tissues for NOC2L Gene

Protein differential expression in normal tissues from HIPED for NOC2L Gene

This gene is overexpressed in Liver (20.5) and Blymphocyte (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOC2L Gene



Protein tissue co-expression partners for NOC2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NOC2L Gene:

NOC2L

SOURCE GeneReport for Unigene cluster for NOC2L Gene:

Hs.405987
genes like me logo Genes that share expression patterns with NOC2L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOC2L Gene

Orthologs for NOC2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOC2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOC2L 35
  • 99 (a)
OneToOne
LOC100608665 34
  • 98.34 (n)
cow
(Bos Taurus)
Mammalia NOC2L 34 35
  • 82.5 (n)
dog
(Canis familiaris)
Mammalia NOC2L 34 35
  • 81.2 (n)
rat
(Rattus norvegicus)
Mammalia Noc2l 34
  • 78.98 (n)
mouse
(Mus musculus)
Mammalia Noc2l 34 16 35
  • 77.39 (n)
oppossum
(Monodelphis domestica)
Mammalia NOC2L 35
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOC2L 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOC2L 34 35
  • 67.03 (n)
lizard
(Anolis carolinensis)
Reptilia NOC2L 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia noc2l 34
  • 62.13 (n)
Str.1780 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5905 34
zebrafish
(Danio rerio)
Actinopterygii noc2l 34 35
  • 61.17 (n)
idibd5110 34
fruit fly
(Drosophila melanogaster)
Insecta CG9246 34 35
  • 50.55 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010536 34
  • 49.29 (n)
worm
(Caenorhabditis elegans)
Secernentea pro-2 34 35
  • 39.75 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL277W 34
  • 46.2 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01122g 34
  • 42.35 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOC2 34 35 37
  • 41.46 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G18220 34
  • 43.44 (n)
rice
(Oryza sativa)
Liliopsida Os10g0495500 34
  • 44.31 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02066 34
  • 47.14 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.04 34
  • 41.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1430 35
  • 33 (a)
OneToOne
Species where no ortholog for NOC2L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOC2L Gene

ENSEMBL:
Gene Tree for NOC2L (if available)
TreeFam:
Gene Tree for NOC2L (if available)

Paralogs for NOC2L Gene

Pseudogenes.org Pseudogenes for NOC2L Gene

genes like me logo Genes that share paralogs with NOC2L: view

No data available for Paralogs for NOC2L Gene

Variants for NOC2L Gene

Sequence variations from dbSNP and Humsavar for NOC2L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10465241 -- 951,437(+) TATTT(C/T)AACAC intron-variant
rs10465242 -- 951,408(+) CTGCA(A/G)GTACC intron-variant
rs111064314 -- 950,285(+) TGCAC(A/G)TAGGT intron-variant
rs111203417 -- 950,376(+) AGACA(C/T)ATGCA intron-variant
rs111288071 -- 949,676(+) GGGAA(A/G)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOC2L Gene

Variant ID Type Subtype PubMed ID
dgv13e59 CNV duplication 20981092
dgv2n67 CNV gain 20364138
dgv5n100 CNV gain 25217958
dgv9n54 CNV loss 21841781
esv2762302 CNV gain 21179565
nsv1013524 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv428334 CNV gain 18775914
nsv482937 CNV loss 15286789
nsv509035 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544895 CNV loss 21841781
nsv832980 CNV gain 17160897
nsv950451 CNV deletion 24416366

Variation tolerance for NOC2L Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOC2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NOC2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOC2L Gene

Disorders for NOC2L Gene

MalaCards: The human disease database

(1) MalaCards diseases for NOC2L Gene - From: DISEASES

Disorder Aliases PubMed IDs
corneal dystrophy, posterior amorphous
  • posterior amorphous corneal dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search NOC2L in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOC2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOC2L
genes like me logo Genes that share disorders with NOC2L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOC2L Gene

Publications for NOC2L Gene

  1. NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. (PMID: 20123734) Heyne K. … Roemer K. (Nucleic Acids Res. 2010) 2 3 4 64
  2. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. (PMID: 16322561) Hublitz P. … Schule R. (Genes Dev. 2005) 3 4 22 64
  3. Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits. (PMID: 22363708) Wu J. … Ke Y. (PLoS ONE 2012) 2 3 64
  4. Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. (PMID: 20959462) Wu L. … Jain A. (J. Biol. Chem. 2011) 3 4 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for NOC2L Gene

Sources for NOC2L Gene

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