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Aliases for NOC2L Gene

Aliases for NOC2L Gene

  • Nucleolar Complex Associated 2 Homolog (S. Cerevisiae) 2 3
  • Novel INHAT Repressor 2 3 4
  • NIR 3 4 6
  • Protein NOC2 Homolog 3 4
  • NOC2-Like Protein 3 4
  • Novel INHAT (Inhibitor Of Histone Acetyltransferase) Repressor 3
  • Protein Phosphatase 1, Regulatory Subunit 12 3
  • Nucleolar Complex Protein 2 Homolog 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 12 2
  • PPP1R112 3
  • NET15 3
  • NET7 3

External Ids for NOC2L Gene

Previous GeneCards Identifiers for NOC2L Gene

  • GC01M000920
  • GC01M000869
  • GC01M000879
  • GC01M000151

Summaries for NOC2L Gene

Entrez Gene Summary for NOC2L Gene

  • Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NOC2L Gene

NOC2L (Nucleolar Complex Associated 2 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and histone binding.

UniProtKB/Swiss-Prot for NOC2L Gene

  • Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.

Gene Wiki entry for NOC2L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOC2L Gene

Genomics for NOC2L Gene

Regulatory Elements for NOC2L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NOC2L Gene

Start:
944,203 bp from pter
End:
959,309 bp from pter
Size:
15,107 bases
Orientation:
Minus strand

Genomic View for NOC2L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOC2L Gene

Proteins for NOC2L Gene

  • Protein details for NOC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3T9-NOC2L_HUMAN
    Recommended name:
    Nucleolar complex protein 2 homolog
    Protein Accession:
    Q9Y3T9
    Secondary Accessions:
    • Q5SVA3
    • Q9BTN6

    Protein attributes for NOC2L Gene

    Size:
    749 amino acids
    Molecular mass:
    84919 Da
    Quaternary structure:
    • Interacts with p53/TP53. Interacts (via the N- and C-terminus domains) with AURKB (via the middle kinase domain). Interacts with TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3 (via N-terminus and non-acetylated form preferentially). Associates with core histones and nucleosomes.

neXtProt entry for NOC2L Gene

Proteomics data for NOC2L Gene at MOPED

Post-translational modifications for NOC2L Gene

  • Ubiquitination at Lys168, Lys516, Lys606, and Lys637
  • Modification sites at PhosphoSitePlus

Other Protein References for NOC2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOC2L Gene

Domains for NOC2L Gene

Protein Domains for NOC2L Gene

Suggested Antigen Peptide Sequences for NOC2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3T9

UniProtKB/Swiss-Prot:

NOC2L_HUMAN :
  • Q9Y3T9
Family:
  • Belongs to the NOC2 family.
genes like me logo Genes that share domains with NOC2L: view

No data available for Gene Families for NOC2L Gene

Function for NOC2L Gene

Molecular function for NOC2L Gene

UniProtKB/Swiss-Prot Function: Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.
UniProtKB/Swiss-Prot Induction: Up-regulated by IL4 and CD40L in B-cells.

Gene Ontology (GO) - Molecular Function for NOC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 16322561
GO:0003714 transcription corepressor activity IDA 16322561
GO:0005488 binding --
GO:0005515 protein binding IPI 16322561
GO:0031491 nucleosome binding IDA 16322561
genes like me logo Genes that share ontologies with NOC2L: view

Phenotypes for NOC2L Gene

genes like me logo Genes that share phenotypes with NOC2L: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOC2L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NOC2L Gene

Localization for NOC2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOC2L Gene

Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOC2L Gene COMPARTMENTS Subcellular localization image for NOC2L gene
Compartment Confidence
nucleus 5
chloroplast 1
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NOC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA 20123734
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with NOC2L: view

Pathways for NOC2L Gene

SuperPathways for NOC2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20123734
GO:0002903 negative regulation of B cell apoptotic process IMP 20959462
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0031497 chromatin assembly IDA 16322561
genes like me logo Genes that share ontologies with NOC2L: view

No data available for Pathways by source for NOC2L Gene

Compounds for NOC2L Gene

(6) Novoseek inferred chemical compound relationships for NOC2L Gene

Compound -log(P) Hits PubMed IDs
dithionite 71.3 1
methyl viologen 68.5 5
copper 53.5 6
nitrate 50.3 5
nitric oxide 2.99 5
genes like me logo Genes that share compounds with NOC2L: view

Transcripts for NOC2L Gene

Unigene Clusters for NOC2L Gene

Nucleolar complex associated 2 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NOC2L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOC2L Gene

No ASD Table

Relevant External Links for NOC2L Gene

GeneLoc Exon Structure for
NOC2L
ECgene alternative splicing isoforms for
NOC2L

Expression for NOC2L Gene

mRNA expression in normal human tissues for NOC2L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOC2L Gene

SOURCE GeneReport for Unigene cluster for NOC2L Gene Hs.405987

genes like me logo Genes that share expressions with NOC2L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOC2L Gene

Orthologs for NOC2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOC2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100608665 35
  • 98.34 (n)
  • 98.12 (a)
NOC2L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOC2L 35
  • 82.5 (n)
  • 79.81 (a)
NOC2L 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOC2L 35
  • 81.2 (n)
  • 79.41 (a)
NOC2L 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Noc2l 35
  • 77.39 (n)
  • 75.64 (a)
Noc2l 16
Noc2l 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOC2L 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOC2L 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Noc2l 35
  • 78.98 (n)
  • 77.45 (a)
chicken
(Gallus gallus)
Aves NOC2L 35
  • 67.03 (n)
  • 64.66 (a)
NOC2L 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOC2L 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5905 35
tropical clawed frog
(Silurana tropicalis)
Amphibia noc2l 35
  • 62.13 (n)
  • 59.57 (a)
Str.1780 35
zebrafish
(Danio rerio)
Actinopterygii idibd5110 35
noc2l 35
  • 61.17 (n)
  • 58.17 (a)
noc2l 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010536 35
  • 49.29 (n)
  • 37.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9246 35
  • 50.55 (n)
  • 39.24 (a)
CG9246 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pro-2 35
  • 39.75 (n)
  • 29.42 (a)
pro-2 36
  • 24 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL277W 35
  • 46.2 (n)
  • 32.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOC2 35
  • 41.46 (n)
  • 33.71 (a)
NOC2 36
  • 27 (a)
OneToOne
NOC2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01122g 35
  • 42.35 (n)
  • 33.22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G18220 35
  • 43.44 (n)
  • 29.6 (a)
rice
(Oryza sativa)
Liliopsida Os10g0495500 35
  • 44.31 (n)
  • 33.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02066 35
  • 47.14 (n)
  • 32.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1142.04 35
  • 41.45 (n)
  • 31.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1430 36
  • 33 (a)
OneToOne
Species with no ortholog for NOC2L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOC2L Gene

ENSEMBL:
Gene Tree for NOC2L (if available)
TreeFam:
Gene Tree for NOC2L (if available)

Paralogs for NOC2L Gene

Pseudogenes.org Pseudogenes for NOC2L Gene

genes like me logo Genes that share paralogs with NOC2L: view

No data available for Paralogs for NOC2L Gene

Variants for NOC2L Gene

Sequence variations from dbSNP and Humsavar for NOC2L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2272756 -- 946,653(-) GTCCC(C/T)TCCTG intron-variant
rs2272757 -- 946,247(-) CACCC(C/T)TGACC reference, synonymous-codon
rs2340582 -- 947,423(-) CACAA(C/T)TGGTC intron-variant
rs3109209 -- 947,541(-) GGGAG(C/G)GCTGT intron-variant
rs3128104 -- 947,541(-) GGAGG(C/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOC2L Gene

Variant ID Type Subtype PubMed ID
dgv3e1 CNV Complex 17122850
essv4734 CNV CNV 17122850
nsv10161 CNV Gain+Loss 18304495
essv2408 CNV CNV 17122850
nsv517709 CNV Gain+Loss 19592680
nsv832980 CNV Gain 17160897
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv509035 CNV Insertion 20534489
dgv8n71 CNV Loss 21882294
nsv871883 CNV Gain+Loss 21882294
dgv9n71 CNV Loss 21882294
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
nsv870660 CNV Loss 21882294
dgv11n71 CNV Loss 21882294

Relevant External Links for NOC2L Gene

HapMap Linkage Disequilibrium report
NOC2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOC2L Gene

Disorders for NOC2L Gene

No disorders were found for NOC2L Gene.

No data available for UniProtKB/Swiss-Prot for NOC2L Gene

Publications for NOC2L Gene

  1. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. (PMID: 16322561) Hublitz P. … Schule R. (Genes Dev. 2005) 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. (PMID: 20123734) Heyne K. … Roemer K. (Nucleic Acids Res. 2010) 3 4

Products for NOC2L Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NOC2L
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for NOC2L
  • Block miRNA regulation of NOC2L using miScript Target Protectors

Sources for NOC2L Gene

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