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Aliases for NOBOX Gene

Aliases for NOBOX Gene

  • NOBOX Oogenesis Homeobox 2 3
  • POF5 3 6
  • Newborn Ovary Homeobox-Encoding Gene 2
  • Newborn Ovary Homeobox-Encoding 3
  • Homeobox Protein NOBOX 3
  • TCAG_12042 3
  • OG-2 3
  • OG2X 3
  • OG2 3

External Ids for NOBOX Gene

Summaries for NOBOX Gene

Entrez Gene Summary for NOBOX Gene

  • This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature ovarian failure type 5.[provided by RefSeq, May 2011]

GeneCards Summary for NOBOX Gene

NOBOX (NOBOX Oogenesis Homeobox) is a Protein Coding gene. Diseases associated with NOBOX include premature ovarian failure 5 and premature ovarian failure. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for NOBOX Gene

  • Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5-TAATTG-3, 5-TAGTTG-3 and 5-TAATTA-3 (By similarity).

Gene Wiki entry for NOBOX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOBOX Gene

Genomics for NOBOX Gene

Genomic Location for NOBOX Gene

Start:
144,397,240 bp from pter
End:
144,410,227 bp from pter
Size:
12,988 bases
Orientation:
Minus strand

Genomic View for NOBOX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOBOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOBOX Gene

Regulatory Elements for NOBOX Gene

Proteins for NOBOX Gene

  • Protein details for NOBOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60393-NOBOX_HUMAN
    Recommended name:
    Homeobox protein NOBOX
    Protein Accession:
    O60393
    Secondary Accessions:
    • A6NCD3
    • A8MZN5

    Protein attributes for NOBOX Gene

    Size:
    691 amino acids
    Molecular mass:
    73906 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC12957.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NOBOX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NOBOX Gene

Proteomics data for NOBOX Gene at MOPED

Post-translational modifications for NOBOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NOBOX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOBOX Gene

Domains for NOBOX Gene

Gene Families for NOBOX Gene

HGNC:
  • PRD :Homeoboxes / PRD class

Protein Domains for NOBOX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NOBOX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60393

UniProtKB/Swiss-Prot:

NOBOX_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • O60393
genes like me logo Genes that share domains with NOBOX: view

Function for NOBOX Gene

Molecular function for NOBOX Gene

UniProtKB/Swiss-Prot Function: Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5-TAATTG-3, 5-TAGTTG-3 and 5-TAATTA-3 (By similarity).

Gene Ontology (GO) - Molecular Function for NOBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with NOBOX: view

Phenotypes for NOBOX Gene

genes like me logo Genes that share phenotypes with NOBOX: view

Animal Models for NOBOX Gene

MGI Knock Outs for NOBOX:

miRNA for NOBOX Gene

miRTarBase miRNAs that target NOBOX

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NOBOX Gene

Localization for NOBOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOBOX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOBOX Gene COMPARTMENTS Subcellular localization image for NOBOX gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NOBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NOBOX: view

Pathways for NOBOX Gene

SuperPathways for NOBOX Gene

No Data Available

Interacting Proteins for NOBOX Gene

Gene Ontology (GO) - Biological Process for NOBOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0048477 oogenesis IEA --
genes like me logo Genes that share ontologies with NOBOX: view

No data available for Pathways by source for NOBOX Gene

Transcripts for NOBOX Gene

mRNA/cDNA for NOBOX Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOBOX Gene

NOBOX oogenesis homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOBOX Gene

No ASD Table

Relevant External Links for NOBOX Gene

GeneLoc Exon Structure for
NOBOX
ECgene alternative splicing isoforms for
NOBOX

Expression for NOBOX Gene

mRNA expression in normal human tissues for NOBOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NOBOX Gene

This gene is overexpressed in Testis (36.8) and Ovary (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NOBOX Gene

SOURCE GeneReport for Unigene cluster for NOBOX Gene Hs.558628

mRNA Expression by UniProt/SwissProt for NOBOX Gene

O60393-NOBOX_HUMAN
Tissue specificity: Expressed in ovaries, testes and pancreas. Expressed within all stages of the adult female germline, from primordial follicles through to MII oocytes.
genes like me logo Genes that share expressions with NOBOX: view

Orthologs for NOBOX Gene

This gene was present in the common ancestor of chordates.

Orthologs for NOBOX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NOBOX 35
  • 99.13 (n)
  • 98.41 (a)
NOBOX 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NOBOX 35
  • 75.76 (n)
  • 67.62 (a)
NOBOX 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOBOX 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nobox 35
  • 70.26 (n)
  • 57.25 (a)
Nobox 16
Nobox 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NOBOX 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOBOX 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nobox 35
  • 73.33 (n)
  • 63.5 (a)
chicken
(Gallus gallus)
Aves NOBOX 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOBOX 36
  • 35 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hbox10-A 35
zebrafish
(Danio rerio)
Actinopterygii nobox 36
  • 21 (a)
OneToOne
Species with no ortholog for NOBOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NOBOX Gene

ENSEMBL:
Gene Tree for NOBOX (if available)
TreeFam:
Gene Tree for NOBOX (if available)

Paralogs for NOBOX Gene

Selected SIMAP similar genes for NOBOX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NOBOX: view

No data available for Paralogs for NOBOX Gene

Variants for NOBOX Gene

Sequence variations from dbSNP and Humsavar for NOBOX Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs727712 -- 144,401,803(+) AAATG(C/T)AGACA intron-variant
rs727713 -- 144,401,829(+) GAGAC(A/G)GCGTT intron-variant
rs727714 -- 144,401,899(+) CACCA(A/G)GGGTA reference, synonymous-codon
rs757388 -- 144,399,746(+) GAGGA(A/G)GAATT intron-variant
rs916968 -- 144,407,069(+) CTTAG(A/C)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOBOX Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
dgv2149e1 CNV Complex 17122850
nsv7411 OTHER Inversion 18451855
nsv831177 CNV Loss 17160897
nsv889377 CNV Loss 21882294

Relevant External Links for NOBOX Gene

HapMap Linkage Disequilibrium report
NOBOX
Human Gene Mutation Database (HGMD)
NOBOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOBOX Gene

Disorders for NOBOX Gene

(1) OMIM Diseases for NOBOX Gene (610934)

UniProtKB/Swiss-Prot

NOBOX_HUMAN
  • Premature ovarian failure 5 (POF5) [MIM:611548]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. {ECO:0000269 PubMed:17701902, ECO:0000269 PubMed:21837770}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for NOBOX Gene

Relevant External Links for NOBOX

Genetic Association Database (GAD)
NOBOX
Human Genome Epidemiology (HuGE) Navigator
NOBOX
genes like me logo Genes that share disorders with NOBOX: view

Publications for NOBOX Gene

  1. cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles. (PMID: 16597639) Huntriss J. … Picton H.M. (Mol. Hum. Reprod. 2006) 2 3 4
  2. NOBOX homeobox mutation causes premature ovarian failure. (PMID: 17701902) Qin Y. … Rajkovic A. (Am. J. Hum. Genet. 2007) 3 4
  3. Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes. (PMID: 11804785) Suzumori N. … Rajkovic A. (Mech. Dev. 2002) 2 3
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Mutation analysis of NOBOX homeodomain in Chinese women with premature ovarian failure. (PMID: 18930203) Qin Y. … Chen Z.J. (Fertil. Steril. 2009) 3 48

Products for NOBOX Gene

Sources for NOBOX Gene

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