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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NOBOX Gene

protein-coding   GIFtS: 47
GCID: GC07M144094

NOBOX Oogenesis Homeobox

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NOBOX Oogenesis Homeobox1 2     OG2X2
POF52 5     TCAG_120422
Newborn Ovary Homeobox-Encoding Gene1     Homeobox Protein NOBOX2
OG-22     Newborn Ovary Homeobox-Encoding2
OG22     

External Ids:    HGNC: 224481   Entrez Gene: 1359352   Ensembl: ENSG000001064107   OMIM: 6109345   UniProtKB: O603933   

Export aliases for NOBOX gene to outside databases

Previous GC identifers: GC07M143533 GC07M143726 GC07M138173


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NOBOX Gene:
This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is
essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature
ovarian failure type 5.(provided by RefSeq, May 2011)

GeneCards Summary for NOBOX Gene: 
NOBOX (NOBOX oogenesis homeobox) is a protein-coding gene. Diseases associated with NOBOX include premature ovarian failure 5, and oophoritis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393
Function: Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences
5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3' (By similarity)

Gene Wiki entry for NOBOX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NOBOX gene promoter:
         C/EBPbeta   FOXF2   GATA-3   HNF-1A   AREB6   POU2F1   POU2F1a   HNF-1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NOBOX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOBOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q35

NOBOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOBOX gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M144094:  view genomic region     (about GC identifiers)

Start:
144,094,333 bp from pter      End:
144,107,320 bp from pter
Size:
12,988 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 143,432,585-143,445,573     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393 (See protein sequence)
Recommended Name: Homeobox protein NOBOX  
Size: 691 amino acids; 73906 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAC12957.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NCD3 A8MZN5
Alternative splicing: 2 isoforms:  O60393-1   O60393-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOBOX: NX_O60393

Explore proteomics data for NOBOX at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60393

  • NOBOX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NOBOX Protein Expression
    REFSEQ proteins: NP_001073882.3  
    ENSEMBL proteins: 
     ENSP00000419565   ENSP00000419457   ENSP00000223140  

    Human Recombinant Protein Products for NOBOX: 
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    OriGene Protein Over-expression Lysate for NOBOX
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOBOX 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NOBOX for ontologies           About GeneDecksing



    NOBOX Antibody Products: 
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    Cloud-Clone Corp. CLIAs for NOBOX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRD: Homeoboxes / PRD class

    2 InterPro protein domains:
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O60393

    ProtoNet protein and cluster: O60393

    UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393
    Similarity: Contains 1 homeobox DNA-binding domain


    NOBOX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOBOX_HUMAN, O60393
    Function: Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences
    5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3' (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    NOBOX for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NOBOX:
     Decreased Wnt reporter activit 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nobox):
     endocrine/exocrine gland  reproductive system 

    NOBOX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Noboxtm1Rajk for NOBOX

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NOBOX 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NOBOX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOBOX 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOBOX 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOBOX
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    Clone
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    OriGene clones in human, mouse for NOBOX (see all 6)
    OriGene ORF clones in mouse, rat for NOBOX
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                         Customized lentivirus expression plasmids for stable overexpression of NOBOX 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOBOX


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOBOX

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0030154cell differentiation IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    NOBOX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NOBOX

    Search CenterWatch for drugs/clinical trials and news about NOBOX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NOBOX gene: 
    NM_001080413.3  

    Unigene Cluster for NOBOX:

    NOBOX oogenesis homeobox
    Hs.558628  [show with all ESTs]
    Unigene Representative Sequence: NM_001080413
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483238 ENST00000467773(uc022aoj.1) ENST00000223140
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOBOX
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NOBOX
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NOBOX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOBOX
    Clone
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    OriGene ORF clones in mouse, rat for NOBOX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOBOX (NM_001080413)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOBOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOBOX
    Sirion Biotech Customized lentivirus for stable overexpression of NOBOX 
                         Customized lentivirus expression plasmids for stable overexpression of NOBOX 
    Primer
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    OriGene qPCR primer pairs and template standards for NOBOX
    OriGene qSTAR qPCR primer pairs in human, mouse for NOBOX
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NOBOX
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOBOX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOBOX

    2 DOTS entries:

    DT.121116056  DT.121116057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NOBOX expression in normal human tissues (normalized intensities)      NOBOX embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTGACTT
    NOBOX Expression
    About this image


    NOBOX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 5 entries
             Primary Oocyte Primordial Follicle
             Ovarian tissue-dissociated cells (human)
             oocyte   
     
     Gonad
             Primary Oocyte Primordial Follicle

    See NOBOX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NOBOX

    SOURCE GeneReport for Unigene cluster: Hs.558628

    UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393
    Tissue specificity: Expressed in ovaries, testes and pancreas. Expressed within all stages of the adult female
    germline, from primordial follicles through to MII oocytes

        SABiosciences Custom PCR Arrays for NOBOX
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOBOX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOBOX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NOBOX gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nobox1 , 5 NOBOX oogenesis homeobox1, 5 70.27(n)1
    57.37(a)1
      6 (21.17 cM)5
    182911  NM_130869.31  NP_570939.11 
     433036745 
    chicken
    (Gallus gallus)
    Aves NOBOX6
    NOBOX oogenesis homeobox
    33(a)
    1 ↔ 1
    1(74550217-74557734)
    lizard
    (Anolis carolinensis)
    Reptilia NOBOX6
    Uncharacterized protein
    32(a)
    1 ↔ 1
    5(82096934-82111405)
    African clawed frog
    (Xenopus laevis)
    Amphibia hbox10-A2 homeobox-containing protein 77.15(n)    L36805.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nobox6
    NOBOX oogenesis homeobox
    21(a)
    1 ↔ 1
    19(44793343-44805126)


    ENSEMBL Gene Tree for NOBOX (if available)
    TreeFam Gene Tree for NOBOX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NOBOX gene
    4 SIMAP similar genes for NOBOX using alignment to 2 protein entries:     NOBOX_HUMAN (see all proteins):
    NKX2-5    MNX1    HOPX    HOXB1

    NOBOX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/351 SNPs in NOBOX are shown (see all 351)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0660144
    Premature ovarian failure 5 (POF5)4--see VAR_0660142 S T mis40--------
    VAR_0366364
    Premature ovarian failure 5 (POF5)4--see VAR_0366362 R H mis40--------
    VAR_0660154
    Premature ovarian failure 5 (POF5)4--see VAR_0660152 V L mis40--------
    rs775873521,2,4
    CPremature ovarian failure 5 (POF5)4 untested1147553637(+) TTTCCC/AAGACA 2 /G /W mis12Minor allele frequency- A:0.00WA EU 711
    rs2019476771,2
    Cpathogenic1147551594(+) CCCGGC/TGATTC 2 H R mis11Minor allele frequency- T:0.00EU 593
    rs78008471,2,4
    C,Funtested1147553288(+) GCCCCG/AGAGCA 2 /R /W mis1 ese34Minor allele frequency- A:0.12WA NA 124
    VAR_0366374
    ----see VAR_0366372 R Q mis40--------
    rs711706311,2
    C--144099842(+) TTTTTT/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs113935831,2
    C,F--144103657(+) AAAAA-/A/AA  
            
    TTGGC
    1 -- int1 trp33NA CSA 6
    rs58881321,2
    C--144104242(+) ATACTA/-AAAAA 1 -- int1 tfbs3 trp31Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for NOBOX (144094333 - 144107320 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NOBOX:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv889377CNV Loss21882294
    nsv831177CNV Loss17160897
    nsv428188CNV Gain+Loss18775914
    dgv2149e1CNV Complex17122850
    dgv2148e1CNV Complex17122850
    nsv7411OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): NOBOX
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NOBOX
    DNA2.0 Custom Variant and Variant Library Synthesis for NOBOX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610934   
    OMIM disorders: 611548  
    UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393
  • Premature ovarian failure 5 (POF5) [MIM:611548]: An ovarian disorder defined as the cessation of ovarian
    function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of
    elevated levels of serum gonadotropins and low estradiol. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 5 diseases for NOBOX:    About MalaCards
    premature ovarian failure 5    oophoritis    premature ovarian failure    ovarian cyst
    amenorrhea

    1 disease from the University of Copenhagen DISEASES database for NOBOX:
    Premature ovarian failure

    NOBOX for disorders           About GeneDecksing

    Genetic Association Database (GAD): NOBOX
    Human Genome Epidemiology (HuGE) Navigator: NOBOX (3 documents)

    Export disorders for NOBOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NOBOX gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with NOBOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles. (PubMed id 16597639)1, 2, 3 Huntriss J.... Picton H.M. (2006)
    2. Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort. (PubMed id 21837770)1, 2 Bouilly J.... Binart N. (2011)
    3. Mutation analysis of NOBOX homeodomain in chinese women with premature ovarian failure. (PubMed id 18930203)1, 4 Qin Y....Chen Z.J. (2008)
    4. NOBOX homeobox mutation causes premature ovarian failure. (PubMed id 17701902)1, 2 Qin Y.... Rajkovic A. (2007)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes. (PubMed id 11804785)1, 3 Suzumori N....Rajkovic A. (2002)
    7. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)
    8. Clinical, biological and genetic analysis of prepuber tal isolated ovarian cyst in 11 girls. (PubMed id 20593028)1 Brauner R....McElreavey K. (2010)
    9. Premature ovarian failure and gene polymorphisms. (PubMed id 19610175)1 van Dooren M.F....Oldenburg R.A. (2009)
    10. A genome-wide linkage scan in a Dutch family identifi es a premature ovarian failure susceptibility locus. (PubMed id 18689850)1 Oldenburg R.A....Bertoli-Avella A.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 135935 HGNC: 22448 Ensembl:ENSG00000106410 euGenes: HUgn135935 ECgene: NOBOX
    H-InvDB: NOBOX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NOBOX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NOBOX gene:
    Search GeneIP for patents involving NOBOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Regulatory tfbs in NOBOX promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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