Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NOBOX Gene

protein-coding   GIFtS: 48
GCID: GC07M144094

NOBOX Oogenesis Homeobox

  See NOBOX-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
NOBOX Oogenesis Homeobox1 2     OG2X2
POF52 5     TCAG_120422
Newborn Ovary Homeobox-Encoding Gene1     Homeobox Protein NOBOX2
OG-22     Newborn Ovary Homeobox-Encoding2
OG22     

External Ids:    HGNC: 224481   Entrez Gene: 1359352   Ensembl: ENSG000001064107   OMIM: 6109345   UniProtKB: O603933   

Export aliases for NOBOX gene to outside databases

Previous GC identifers: GC07M143533 GC07M143726 GC07M138173


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NOBOX Gene:
This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is
essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature
ovarian failure type 5.(provided by RefSeq, May 2011)

GeneCards Summary for NOBOX Gene:
NOBOX (NOBOX oogenesis homeobox) is a protein-coding gene. Diseases associated with NOBOX include premature ovarian failure 5, and premature ovarian failure. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393
Function: Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences
5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3' (By similarity)

Gene Wiki entry for NOBOX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOBOX gene promoter:
         C/EBPbeta   FOXF2   GATA-3   HNF-1A   AREB6   POU2F1   POU2F1a   HNF-1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NOBOX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOBOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q35

NOBOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOBOX gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M144094:  view genomic region     (about GC identifiers)

Start:
144,094,333 bp from pter      End:
144,107,320 bp from pter
Size:
12,988 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 143,432,585-143,445,573     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393 (See protein sequence)
Recommended Name: Homeobox protein NOBOX  
Size: 691 amino acids; 73906 Da
Sequence caution: Sequence=AAC12957.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NCD3 A8MZN5
Alternative splicing: 2 isoforms:  O60393-1   O60393-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NOBOX: NX_O60393

Explore proteomics data for NOBOX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NOBOX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073882.3  
    ENSEMBL proteins: 
     ENSP00000419565   ENSP00000419457   ENSP00000223140  

    NOBOX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NOBOX
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NOBOX
    GenScript Custom Purified and Recombinant Proteins Services for NOBOX
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NOBOX

     
    Search eBioscience for Proteins for NOBOX 

     
    antibodies-online proteins for NOBOX (3 products) 

     
    antibodies-online peptides for NOBOX

    NOBOX Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NOBOX
    Novus Biologicals NOBOX Antibody
    Search for Antibodies for NOBOX at Abcam
    Cloud-Clone Corp. Antibodies for NOBOX
    Search ThermoFisher Antibodies for NOBOX
    antibodies-online antibodies for NOBOX (21 products) 

    NOBOX Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NOBOX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NOBOX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NOBOX
    Cloud-Clone Corp. CLIAs for NOBOX
    Search eBioscience for ELISAs for NOBOX 
    antibodies-online kits for NOBOX (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PRD: Homeoboxes / PRD class

    2 InterPro protein domains:
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O60393

    ProtoNet protein and cluster: O60393

    UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with NOBOX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOBOX_HUMAN, O60393
    Function: Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences
    5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3' (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with NOBOX           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NOBOX:
     Decreased Wnt reporter activit 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nobox):
     endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with NOBOX           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Noboxtm1Rajk for NOBOX

       genOway: Develop your customized and physiologically relevant rodent model for NOBOX

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOBOX:
    hsa-mir-335-5p (MIRT018764)

    Block miRNA regulation of human, mouse, rat NOBOX using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NOBOX
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOBOX
    Predesigned siRNA for gene silencing in human, mouse, rat NOBOX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NOBOX

    Clone
    Products:
         
    OriGene clones in human, mouse for NOBOX (see all 6)
    OriGene ORF clones in mouse, rat for NOBOX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOBOX (NM_001080413)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOBOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOBOX

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NOBOX
    Browse ESI BIO Cell Lines and PureStem Progenitors for NOBOX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOBOX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NOBOX_HUMAN, O60393: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with NOBOX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOBOX
    Interactions:

        Search GeneGlobe Interaction Network for NOBOX

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NOBOX (ENSP000002231404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK2ENSP000003720234STRING: ENSP00000372023
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0030154cell differentiation IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    Find genes that share ontologies with NOBOX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOBOX



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NOBOX gene: 
    NM_001080413.3  

    Unigene Cluster for NOBOX:

    NOBOX oogenesis homeobox
    Hs.558628  [show with all ESTs]
    Unigene Representative Sequence: NM_001080413
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483238 ENST00000467773(uc022aoj.1) ENST00000223140
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NOBOX using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NOBOX
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NOBOX
    Predesigned siRNA for gene silencing in human, mouse, rat NOBOX
    Clone
    Products:
         
    OriGene clones in human, mouse for NOBOX (see all 6)
    OriGene ORF clones in mouse, rat for NOBOX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOBOX (NM_001080413)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOBOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOBOX
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NOBOX
    OriGene qSTAR qPCR primer pairs in human, mouse for NOBOX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOBOX
      QuantiTect SYBR Green Assays in human, mouse, rat NOBOX
      QuantiFast Probe-based Assays in human, mouse, rat NOBOX

    2 DOTS entries:

    DT.121116056  DT.121116057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NOBOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTGACTT
    NOBOX Expression
    About this image


    NOBOX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 6 entries
             Primary Oocyte Primordial Follicle
             Ovarian tissue-dissociated cells (human)
             Oocytes
             oocyte   
     
     Gonad
             Primary Oocyte Primordial Follicle
             Human oogonial stem cells
     
     Germ Cells (Reproductive System)
             Human oogonial stem cells
    NOBOX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOBOX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558628

    UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393
    Tissue specificity: Expressed in ovaries, testes and pancreas. Expressed within all stages of the adult female
    germline, from primordial follicles through to MII oocytes

        Custom PCR Arrays for NOBOX
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NOBOX
    OriGene qSTAR qPCR primer pairs in human, mouse for NOBOX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOBOX
    QuantiTect SYBR Green Assays in human, mouse, rat NOBOX
    QuantiFast Probe-based Assays in human, mouse, rat NOBOX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOBOX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for NOBOX gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nobox1 , 5 NOBOX oogenesis homeobox1, 5 70.26(n)1
    57.25(a)1
      6 (21.17 cM)5
    182911  NM_130869.31  NP_570939.11 
     433036745 
    chicken
    (Gallus gallus)
    Aves NOBOX6
    NOBOX oogenesis homeobox
    36(a)
    1 ↔ 1
    1(74550217-74557734)
    lizard
    (Anolis carolinensis)
    Reptilia NOBOX6
    NOBOX oogenesis homeobox
    35(a)
    1 ↔ 1
    5(82096934-82111405)
    African clawed frog
    (Xenopus laevis)
    Amphibia hbox10-A2 homeobox-containing protein 77.15(n)    L36805.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nobox6
    NOBOX oogenesis homeobox
    21(a)
    1 ↔ 1
    19(44793343-44805126) ENSDARG00000086137


    ENSEMBL Gene Tree for NOBOX (if available)
    TreeFam Gene Tree for NOBOX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NOBOX gene
    4 SIMAP similar genes for NOBOX using alignment to 2 protein entries:     NOBOX_HUMAN (see all proteins):
    NKX2-5    MNX1    HOPX    HOXB1

    Find genes that share paralogs with NOBOX           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NOBOX (see all 351)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs775873521,2,,4
    CPremature ovarian failure 5 (POF5)4 untested1147553637(+) TTTCCC/AAGACA 2 /G /W mis12Minor allele frequency- A:0.00WA EU 711
    VAR_0660144
    Premature ovarian failure 5 (POF5)4--see VAR_0660142 S T mis40--------
    VAR_0366364
    Premature ovarian failure 5 (POF5)4--see VAR_0366362 R H mis40--------
    VAR_0660154
    Premature ovarian failure 5 (POF5)4--see VAR_0660152 V L mis40--------
    rs2019476771,2
    Cpathogenic1147551594(+) CCCGGC/TGATTC 2 H R mis11Minor allele frequency- T:0.00EU 593
    rs78008471,2,,4
    C,Funtested1147553288(+) GCCCCG/AGAGCA 2 /R /W mis1 ese34Minor allele frequency- A:0.12WA NA 124
    rs711706311,2
    C--144099842(+) TTTTTT/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs113935831,2
    C,F--144103657(+) AAAAA-/A/AA  
            
    TTGGC
    1 -- int1 trp33NA CSA 6
    rs58881321,2
    C--144104242(+) ATACTA/-AAAAA 1 -- int1 tfbs3 trp31Minor allele frequency- -:0.00NA 2
    rs1463696131,2
    --147548680(+) CTTACA/GGTGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NOBOX (144094333 - 144107320 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NOBOX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv889377CNV Loss21882294
    nsv831177CNV Loss17160897
    nsv428188CNV Gain+Loss18775914
    dgv2149e1CNV Complex17122850
    dgv2148e1CNV Complex17122850
    nsv7411OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): NOBOX
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOBOX
    DNA2.0 Custom Variant and Variant Library Synthesis for NOBOX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610934   
    OMIM disorders: 611548  
    UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393
  • Premature ovarian failure 5 (POF5) [MIM:611548]: An ovarian disorder defined as the cessation of ovarian
    function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of
    elevated levels of serum gonadotropins and low estradiol. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 3 diseases for NOBOX:    
    About MalaCards
    premature ovarian failure 5    premature ovarian failure    ovarian cyst

    1 disease from the University of Copenhagen DISEASES database for NOBOX:
    Premature ovarian failure

    Find genes that share disorders with NOBOX           About GenesLikeMe

    Genetic Association Database (GAD): NOBOX
    Human Genome Epidemiology (HuGE) Navigator: NOBOX (3 documents)

    Export disorders for NOBOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NOBOX gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with NOBOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles. (PubMed id 16597639)1, 2, 3 Huntriss J.... Picton H.M. (Mol. Hum. Reprod. 2006)
    2. Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort. (PubMed id 21837770)1, 2 Bouilly J.... Binart N. (Hum. Mutat. 2011)
    3. Mutation analysis of NOBOX homeodomain in Chinese women with premature ovarian failure. (PubMed id 18930203)1, 4 Qin Y....Chen Z.J. (Fertil. Steril. 2009)
    4. NOBOX homeobox mutation causes premature ovarian failure. (PubMed id 17701902)1, 2 Qin Y.... Rajkovic A. (Am. J. Hum. Genet. 2007)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes. (PubMed id 11804785)1, 3 Suzumori N....Rajkovic A. (Mech. Dev. 2002)
    7. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
    8. Clinical, biological and genetic analysis of prepubertal isolated ovarian cyst in 11 girls. (PubMed id 20593028)1 Brauner R....McElreavey K. (PLoS ONE 2010)
    9. Premature ovarian failure and gene polymorphisms. (PubMed id 19610175)1 van Dooren M.F....Oldenburg R.A. (amp 2009)
    10. A genome-wide linkage scan in a Dutch family identifies a premature ovarian failure susceptibility locus. (PubMed id 18689850)1 Oldenburg R.A....Bertoli-Avella A.M. (Hum. Reprod. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 135935 HGNC: 22448 Ensembl:ENSG00000106410 euGenes: HUgn135935 ECgene: NOBOX
    H-InvDB: NOBOX

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NOBOX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NOBOX gene:
    Search GeneIP for patents involving NOBOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NOBOX  
     OriGene qPCR primer pairs and template standards for NOBOX   OriGene Protein Over-expression Lysate for NOBOX  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NOBOX  
     OriGene qSTAR qPCR primer pairs in human, mouse for NOBOX   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NOBOX   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NOBOX   OriGene Custom Protein Services for NOBOX  

     
     
     Block miRNA regulation of human, mouse, rat NOBOX using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NOBOX
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOBOX Predesigned siRNA for gene silencing in human, mouse, rat NOBOX
     QuantiFast Probe-based Assays in human, mouse, rat NOBOX QuantiTect SYBR Green Assays in human, mouse, rat NOBOX
     Custom PCR Arrays for NOBOX Search Chromatin IP Primers for NOBOX
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOBOX  Search GeneGlobe Interaction Network for NOBOX
     Regulatory tfbs in NOBOX promoter
     GenScript Custom Purified and Recombinant Proteins Services for NOBOX GenScript cDNA clones with any tag delivered in your preferred vector for NOBOX
     GenScript Custom Assay Services for NOBOX GenScript Custom overexpressing Cell Line Services for NOBOX
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NOBOX
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NOBOX antibodies
     Search for Antibodies for NOBOX at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NOBOX
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NOBOX
     Antibodies for NOBOX
     ELISAs for NOBOX
     CLIAs for NOBOX



     Browse ESI BIO Cell Lines and PureStem Progenitors for NOBOX
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOBOX
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NOBOX
     Browse SwitchGear Promoter luciferase reporter plasmids for NOBOX
     Search ThermoFisher Antibodies for NOBOX
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOBOX
     Browse compounds at ApexBio
     Search Addgene for plasmids for NOBOX
      Search eBioscience for proteins for NOBOX
      Search eBioscience for elisas for NOBOX
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for NOBOX
     antibodies-online antibodies for NOBOX (21 products)
     antibodies-online kits for NOBOX (4 products)
     antibodies-online peptides for NOBOX
     antibodies-online proteins for NOBOX (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NOBOX gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4