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Aliases for NOB1 Gene

Aliases for NOB1 Gene

  • NIN1/PSMD8 Binding Protein 1 Homolog 2 3
  • NIN1/RPN12 Binding Protein 1 Homolog 2 3 5
  • Phosphorylation Regulatory Protein HP-10 3 4
  • Nin One Binding Protein 2 3
  • PSMD8 Binding Protein 1 2 3
  • Protein ART-4 3 4
  • PSMD8BP1 3 4
  • NOB1P 3 4
  • NIN1/RPN12 Binding Protein 1 Homolog (S. Cerevisiae) 2
  • Adenocarcinoma Antigen Recognized By T Lymphocytes 4 3
  • MSTP158 3
  • MST158 3
  • ART-4 3
  • ART4 4

External Ids for NOB1 Gene

Previous HGNC Symbols for NOB1 Gene

  • PSMD8BP1

Previous GeneCards Identifiers for NOB1 Gene

  • GC16M068334
  • GC16M055654

Summaries for NOB1 Gene

Entrez Gene Summary for NOB1 Gene

  • In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]

GeneCards Summary for NOB1 Gene

NOB1 (NIN1/PSMD8 Binding Protein 1 Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing.

UniProtKB/Swiss-Prot for NOB1 Gene

  • May play a role in mRNA degradation.

Gene Wiki entry for NOB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOB1 Gene

Genomics for NOB1 Gene

Regulatory Elements for NOB1 Gene

Enhancers for NOB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NOB1 on UCSC Golden Path with GeneCards custom track

Promoters for NOB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOB1 Gene

Chromosome:
16
Start:
69,741,854 bp from pter
End:
69,754,968 bp from pter
Size:
13,115 bases
Orientation:
Minus strand

Genomic View for NOB1 Gene

Genes around NOB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOB1 Gene

Proteins for NOB1 Gene

  • Protein details for NOB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULX3-NOB1_HUMAN
    Recommended name:
    RNA-binding protein NOB1
    Protein Accession:
    Q9ULX3
    Secondary Accessions:
    • Q7L6B7
    • Q7M4M4
    • Q7Z4B5
    • Q9NWB0

    Protein attributes for NOB1 Gene

    Size:
    412 amino acids
    Molecular mass:
    46675 Da
    Quaternary structure:
    • Interacts with UPF2.
    SequenceCaution:
    • Sequence=AAQ13705.1; Type=Frameshift; Positions=393; Evidence={ECO:0000305}; Sequence=BAA91473.1; Type=Frameshift; Positions=87; Evidence={ECO:0000305};

neXtProt entry for NOB1 Gene

Proteomics data for NOB1 Gene at MOPED

Post-translational modifications for NOB1 Gene

  • Ubiquitination at Lys 25, Lys 40, Lys 291, Lys 315, Lys 333, and Lys 358
  • Modification sites at PhosphoSitePlus

Other Protein References for NOB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOB1 Gene

Domains & Families for NOB1 Gene

Protein Domains for NOB1 Gene

Suggested Antigen Peptide Sequences for NOB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULX3

UniProtKB/Swiss-Prot:

NOB1_HUMAN :
  • Contains 1 PINc domain.
  • Belongs to the NOB1 family.
Domain:
  • Contains 1 PINc domain.
Family:
  • Belongs to the NOB1 family.
genes like me logo Genes that share domains with NOB1: view

No data available for Gene Families for NOB1 Gene

Function for NOB1 Gene

Molecular function for NOB1 Gene

GENATLAS Biochemistry:
new organization associated with HLA-B,gene NOB1
UniProtKB/Swiss-Prot Function:
May play a role in mRNA degradation.
genes like me logo Genes that share phenotypes with NOB1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOB1 Gene

Localization for NOB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOB1 Gene COMPARTMENTS Subcellular localization image for NOB1 gene
Compartment Confidence
nucleus 4
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NOB1: view

Pathways & Interactions for NOB1 Gene

genes like me logo Genes that share pathways with NOB1: view

Pathways by source for NOB1 Gene

Gene Ontology (GO) - Biological Process for NOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000469 cleavage involved in rRNA processing IBA --
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with NOB1: view

No data available for SIGNOR curated interactions for NOB1 Gene

Drugs & Compounds for NOB1 Gene

No Compound Related Data Available

Transcripts for NOB1 Gene

Unigene Clusters for NOB1 Gene

NIN1/RPN12 binding protein 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOB1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3:

Relevant External Links for NOB1 Gene

GeneLoc Exon Structure for
NOB1
ECgene alternative splicing isoforms for
NOB1

Expression for NOB1 Gene

mRNA expression in normal human tissues for NOB1 Gene

Protein differential expression in normal tissues from HIPED for NOB1 Gene

This gene is overexpressed in Breast (46.2) and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOB1 Gene



SOURCE GeneReport for Unigene cluster for NOB1 Gene Hs.271695

mRNA Expression by UniProt/SwissProt for NOB1 Gene

Q9ULX3-NOB1_HUMAN
Tissue specificity: Detected in liver, lung, placenta, endothelial cells and spleen.
genes like me logo Genes that share expression patterns with NOB1: view

Protein tissue co-expression partners for NOB1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NOB1 Gene

Orthologs for NOB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOB1 35
  • 88.16 (n)
  • 90.02 (a)
NOB1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOB1 35
  • 87.78 (n)
  • 90.29 (a)
NOB1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nob1 35
  • 85.82 (n)
  • 89.55 (a)
Nob1 16
Nob1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOB1 35
  • 99.19 (n)
  • 99.03 (a)
NOB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nob1 35
  • 86.31 (n)
  • 89.49 (a)
oppossum
(Monodelphis domestica)
Mammalia NOB1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOB1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOB1 35
  • 69.58 (n)
  • 66.75 (a)
NOB1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOB1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nob1 35
  • 67.66 (n)
  • 67.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398701 35
zebrafish
(Danio rerio)
Actinopterygii nob1 35
  • 65.76 (n)
  • 65.1 (a)
wufc27e05 35
nob1 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5629 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004064 35
  • 52.13 (n)
  • 43.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2972 35
  • 54.1 (n)
  • 45.79 (a)
CG2972 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54E10BR.4 35
  • 47.97 (n)
  • 37.68 (a)
Y54E10BR.4 36
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR139W 35
  • 48.76 (n)
  • 36.42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16280g 35
  • 42.97 (n)
  • 32.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOB1 35
  • 42.88 (n)
  • 32.55 (a)
NOB1 36
  • 26 (a)
OneToOne
NOB1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4034 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08904 35
  • 45.82 (n)
  • 35.16 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1486.09 35
  • 46.5 (n)
  • 37.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1867 36
  • 47 (a)
OneToOne
Species with no ortholog for NOB1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOB1 Gene

ENSEMBL:
Gene Tree for NOB1 (if available)
TreeFam:
Gene Tree for NOB1 (if available)

Paralogs for NOB1 Gene

Pseudogenes.org Pseudogenes for NOB1 Gene

genes like me logo Genes that share paralogs with NOB1: view

No data available for Paralogs for NOB1 Gene

Variants for NOB1 Gene

Sequence variations from dbSNP and Humsavar for NOB1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3811348 - 69,748,952(+) CAACC(C/T)GCACG nc-transcript-variant, reference, missense
rs1075935 - 69,742,474(-) TGACT(A/T)CATCG nc-transcript-variant, reference, missense
rs4247107 -- 69,751,135(+) ggctg(A/G)agtgc intron-variant
rs8063483 -- 69,756,672(+) GGTCA(A/G)TCCCA upstream-variant-2KB
rs4436770 -- 69,756,205(+) AAAAA(A/C)AACAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NOB1 Gene

Variant ID Type Subtype PubMed ID
nsv906823 CNV Gain 21882294
nsv524364 CNV Loss 19592680

Variation tolerance for NOB1 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.12; 90.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NOB1 Gene

Disorders for NOB1 Gene

Relevant External Links for NOB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOB1

No disorders were found for NOB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOB1 Gene

Publications for NOB1 Gene

  1. Cloning, expression and characterization of the human NOB1 gene. (PMID: 16172919) Zhang Y. … Zhao S. (Mol. Biol. Rep. 2005) 2 3 4 23 67
  2. Evaluation of NIN/RPN12 binding protein inhibits proliferation and growth in human renal cancer cells. (PMID: 25420906) Jia J.W. … Tan J. (Tumour Biol. 2015) 3
  3. Relationship between NOB1 expression and prognosis of resected non-small cell lung cancer. (PMID: 25450647) Liu K. … You Q.S. (Int. J. Biol. Markers 2015) 3
  4. Positive nin one binding protein expression predicts poor outcome in prostate cancer. (PMID: 25503472) Chen J. … Gao Y. (Mol Med Rep 2015) 3
  5. NOB1 is essential for the survival of RKO colorectal cancer cells. (PMID: 25624720) He X.W. … Liu T. (World J. Gastroenterol. 2015) 3

Products for NOB1 Gene

Sources for NOB1 Gene

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