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Aliases for NOB1 Gene

Aliases for NOB1 Gene

  • NIN1/PSMD8 Binding Protein 1 Homolog 2 3 5
  • Phosphorylation Regulatory Protein HP-10 3 4
  • NIN1/RPN12 Binding Protein 1 Homolog 2 3
  • Nin One Binding Protein 2 3
  • PSMD8 Binding Protein 1 2 3
  • Protein ART-4 3 4
  • PSMD8BP1 3 4
  • NOB1P 3 4
  • NIN1/RPN12 Binding Protein 1 Homolog (S. Cerevisiae) 2
  • Adenocarcinoma Antigen Recognized By T Lymphocytes 4 3
  • RNA-Binding Protein NOB1 3
  • MSTP158 3
  • MST158 3
  • ART-4 3
  • ART4 4

External Ids for NOB1 Gene

Previous HGNC Symbols for NOB1 Gene

  • PSMD8BP1

Previous GeneCards Identifiers for NOB1 Gene

  • GC16M068334
  • GC16M055654

Summaries for NOB1 Gene

Entrez Gene Summary for NOB1 Gene

  • In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]

GeneCards Summary for NOB1 Gene

NOB1 (NIN1/PSMD8 Binding Protein 1 Homolog) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Ribosome biogenesis in eukaryotes.

UniProtKB/Swiss-Prot for NOB1 Gene

  • May play a role in mRNA degradation.

Gene Wiki entry for NOB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOB1 Gene

Genomics for NOB1 Gene

Regulatory Elements for NOB1 Gene

Enhancers for NOB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F069829 1.7 FANTOM5 Ensembl ENCODE 18.2 -77.1 -77076 5.5 PKNOX1 ZFP64 ARID4B SLC30A9 ZNF766 ZNF302 CBX5 FOS NFYC ZHX2 PDPR SF3B3 NONOP1 LOC400541 PDXDC2P NPIPB14P CHTF8 EXOSC6 NOB1 NQO1
GH16F069402 1.7 FANTOM5 Ensembl ENCODE 18.1 +346.9 346902 11.7 PKNOX1 MLX ZFP64 ARID4B FEZF1 DMAP1 YY1 SLC30A9 ZNF302 FOS PDPR NONOP1 LOC400541 PDXDC2P NIP7 CHTF8 TMED6 NOB1 UTP4 NPIPB14P
GH16F069070 1.3 Ensembl ENCODE 19.2 +682.3 682264 3.6 ATF1 PKNOX1 ARID4B SIN3A FEZF1 ETS1 GTF3C2 GLIS2 FOS DEK NONOP1 CHTF8 ENSG00000263276 NOB1 PDXDC2P NIP7 NPIPB14P ENSG00000262514 SNTB2 CDH1
GH16F069105 1 ENCODE 18.1 +648.0 647967 3.9 ATF1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 GLIS2 SP3 TSHZ1 REST NONOP1 PDXDC2P CHTF8 NPIPB14P ENSG00000263276 NOB1 SNTB2 NIP7 ENSG00000262514 SLC7A6OS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NOB1 on UCSC Golden Path with GeneCards custom track

Promoters for NOB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000149329 568 2000 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for NOB1 Gene

69,741,854 bp from pter
69,754,968 bp from pter
13,115 bases
Minus strand

Genomic View for NOB1 Gene

Genes around NOB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOB1 Gene

Proteins for NOB1 Gene

  • Protein details for NOB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein NOB1
    Protein Accession:
    Secondary Accessions:
    • Q7L6B7
    • Q7M4M4
    • Q7Z4B5
    • Q9NWB0

    Protein attributes for NOB1 Gene

    412 amino acids
    Molecular mass:
    46675 Da
    Quaternary structure:
    • Interacts with UPF2.
    • Sequence=AAQ13705.1; Type=Frameshift; Positions=393; Evidence={ECO:0000305}; Sequence=BAA91473.1; Type=Frameshift; Positions=87; Evidence={ECO:0000305};

neXtProt entry for NOB1 Gene

Post-translational modifications for NOB1 Gene

  • Ubiquitination at Lys 25, Lys 40, Lys 291, Lys 315, Lys 333, and Lys 358
  • Modification sites at PhosphoSitePlus

Other Protein References for NOB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOB1 Gene

Domains & Families for NOB1 Gene

Suggested Antigen Peptide Sequences for NOB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PINc domain.
  • Belongs to the NOB1 family.
  • Contains 1 PINc domain.
  • Belongs to the NOB1 family.
genes like me logo Genes that share domains with NOB1: view

No data available for Gene Families for NOB1 Gene

Function for NOB1 Gene

Molecular function for NOB1 Gene

GENATLAS Biochemistry:
new organization associated with HLA-B,gene NOB1
UniProtKB/Swiss-Prot Function:
May play a role in mRNA degradation.

Gene Ontology (GO) - Molecular Function for NOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004521 endoribonuclease activity TAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NOB1: view
genes like me logo Genes that share phenotypes with NOB1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NOB1 Gene

Localization for NOB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOB1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NOB1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0030688 preribosome, small subunit precursor IBA --
genes like me logo Genes that share ontologies with NOB1: view

Pathways & Interactions for NOB1 Gene

genes like me logo Genes that share pathways with NOB1: view

Gene Ontology (GO) - Biological Process for NOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000469 cleavage involved in rRNA processing IBA --
GO:0006364 rRNA processing TAS --
GO:0007601 visual perception IEA --
GO:0030490 maturation of SSU-rRNA IBA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with NOB1: view

No data available for SIGNOR curated interactions for NOB1 Gene

Transcripts for NOB1 Gene

Unigene Clusters for NOB1 Gene

NIN1/RPN12 binding protein 1 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NOB1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -

Relevant External Links for NOB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NOB1 Gene

Protein differential expression in normal tissues from HIPED for NOB1 Gene

This gene is overexpressed in Breast (46.2) and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NOB1 Gene

Protein tissue co-expression partners for NOB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NOB1 Gene:


SOURCE GeneReport for Unigene cluster for NOB1 Gene:


mRNA Expression by UniProt/SwissProt for NOB1 Gene:

Tissue specificity: Detected in liver, lung, placenta, endothelial cells and spleen.
genes like me logo Genes that share expression patterns with NOB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NOB1 Gene

Orthologs for NOB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NOB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOB1 34 35
  • 99.19 (n)
(Bos Taurus)
Mammalia NOB1 34 35
  • 88.16 (n)
(Canis familiaris)
Mammalia NOB1 34 35
  • 87.78 (n)
(Rattus norvegicus)
Mammalia Nob1 34
  • 86.31 (n)
(Mus musculus)
Mammalia Nob1 34 16 35
  • 85.82 (n)
(Monodelphis domestica)
Mammalia NOB1 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia NOB1 35
  • 65 (a)
(Gallus gallus)
Aves NOB1 34 35
  • 69.58 (n)
(Anolis carolinensis)
Reptilia NOB1 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nob1 34
  • 67.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398701 34
(Danio rerio)
Actinopterygii nob1 35 34
  • 65.76 (n)
wufc27e05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5629 34
fruit fly
(Drosophila melanogaster)
Insecta CG2972 34 35
  • 54.1 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004064 34
  • 52.13 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y54E10BR.4 34
  • 47.97 (n)
Y54E10BR.4 35
  • 37 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR139W 34
  • 48.76 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16280g 34
  • 42.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOB1 34 35 37
  • 42.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1867 35
  • 47 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1486.09 34
  • 46.5 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08904 34
  • 45.82 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4034 34
Species where no ortholog for NOB1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOB1 Gene

Gene Tree for NOB1 (if available)
Gene Tree for NOB1 (if available)

Paralogs for NOB1 Gene Pseudogenes for NOB1 Gene

genes like me logo Genes that share paralogs with NOB1: view

No data available for Paralogs for NOB1 Gene

Variants for NOB1 Gene

Sequence variations from dbSNP and Humsavar for NOB1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1075935 -- 69,742,474(-) TGACT(A/T)CATCG nc-transcript-variant, reference, missense
rs111261140 -- 69,742,101(+) CTGTT(C/G/T)TTATG nc-transcript-variant, utr-variant-3-prime
rs111271634 -- 69,752,801(+) GTAGC(-/G)GGGGG intron-variant
rs111401790 -- 69,756,204(+) AAAAA(A/C)CAACA upstream-variant-2KB
rs111725413 -- 69,748,339(+) AACCA(C/T)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NOB1 Gene

Variant ID Type Subtype PubMed ID
esv3638928 CNV gain 21293372
esv3638930 CNV gain 21293372
esv3638931 CNV gain 21293372
esv3892878 CNV gain 25118596
nsv524364 CNV loss 19592680

Variation tolerance for NOB1 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.12; 90.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NOB1 Gene

Disorders for NOB1 Gene

Relevant External Links for NOB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NOB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NOB1 Gene

Publications for NOB1 Gene

  1. Cloning, expression and characterization of the human NOB1 gene. (PMID: 16172919) Zhang Y. … Zhao S. (Mol. Biol. Rep. 2005) 2 3 4 22 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A protein interaction framework for human mRNA degradation. (PMID: 15231747) Lehner B. … Sanderson C.M. (Genome Res. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NOB1 Gene

Sources for NOB1 Gene

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