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NOB1 Gene

protein-coding   GIFtS: 58
GCID: GC16M069775

NIN1/RPN12 Binding Protein 1 Homolog (S. Cerevisiae)

(Previous name: PSMD8 binding protein 1)
(Previous symbol: PSMD8BP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NIN1/RPN12 Binding Protein 1 Homolog (S. Cerevisiae)1 2     NOB1P2 3
PSMD8BP11 2 3     ART-42
PSMD8 Binding Protein 11 2     MST1582
Nin One Binding Protein1 2     Adenocarcinoma Antigen Recognized By T Lymphocytes 42
Phosphorylation Regulatory Protein HP-102 3     RNA-Binding Protein NOB12
Protein ART-42 3     ART43

External Ids:    HGNC: 295401   Entrez Gene: 289872   Ensembl: ENSG000001411017   OMIM: 6135865   UniProtKB: Q9ULX33   

Export aliases for NOB1 gene to outside databases

Previous GC identifers: GC16M068334 GC16M055654


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NOB1 Gene:
In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved
in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript
into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1
is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate
at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 (PubMed 19706509)).(supplied by
OMIM, Nov 2010)

GeneCards Summary for NOB1 Gene:
NOB1 (NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with NOB1 include adenocarcinoma, and thymoma.

UniProtKB/Swiss-Prot: NOB1_HUMAN, Q9ULX3
Function: May play a role in mRNA degradation

Gene Wiki entry for NOB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NOB1 gene promoter:
         NF-AT2   GATA-3   AP-1   NF-AT3   NF-AT1   NF-AT   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOB1 promoter sequence
   Search Chromatin IP Primers for NOB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.3   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

NOB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOB1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M069775:  view genomic region     (about GC identifiers)

Start:
69,775,770 bp from pter      End:
69,788,843 bp from pter
Size:
13,074 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NOB1_HUMAN, Q9ULX3 (See protein sequence)
Recommended Name: RNA-binding protein NOB1  
Size: 412 amino acids; 46675 Da
Subunit: Interacts with UPF2 (Probable)
Sequence caution: Sequence=AAQ13705.1; Type=Frameshift; Positions=393; Sequence=BAA91473.1; Type=Frameshift;
Positions=87;
Secondary accessions: Q7L6B7 Q7M4M4 Q7Z4B5 Q9NWB0

Explore the universe of human proteins at neXtProt for NOB1: NX_Q9ULX3

Explore proteomics data for NOB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys25, Lys40, Lys291, Lys315, Lys333, Lys358
  • Modification sites at PhosphoSitePlus

  • See NOB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054781.1  
    ENSEMBL proteins: 
     ENSP00000268802   ENSP00000457760   ENSP00000456710  

    NOB1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for NOB1
    Cloud-Clone Corp. CLIAs for NOB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014881 NOB1_Zn-bd
     IPR002716 PIN_dom
     IPR017117 D-site_20S_pre-rRNA_nuclease

    Graphical View of Domain Structure for InterPro Entry Q9ULX3

    ProtoNet protein and cluster: Q9ULX3

    2 Blocks protein domains:
    IPB002110 Ankyrin repeat signature
    IPB006596 Nucleotide binding protein


    UniProtKB/Swiss-Prot: NOB1_HUMAN, Q9ULX3
    Similarity: Belongs to the NOB1 family
    Similarity: Contains 1 PINc domain


    NOB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOB1_HUMAN, Q9ULX3
    Function: May play a role in mRNA degradation

         Genatlas biochemistry entry for NOB1:
    new organization associated with HLA-B,gene NOB1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    NOB1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NOB1:
     Decreased viability of wild-ty  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOB1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NOB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NOB1:
    hsa-mir-93-5p (MIRT048820), hsa-mir-192-5p (MIRT026103), hsa-mir-10a-5p (MIRT047740), hsa-mir-16-5p (MIRT005263), hsa-mir-296-3p (MIRT038404), hsa-mir-215-5p (MIRT024702), hsa-mir-935 (MIRT036663), hsa-mir-29c-5p (MIRT038545), hsa-mir-155-5p (MIRT020518)

    Block miRNA regulation of human, mouse, rat NOB1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NOB1:
    hsa-miR-3128
    SwitchGear 3'UTR luciferase reporter plasmidNOB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NOB1
    Predesigned siRNA for gene silencing in human, mouse, rat NOB1

    Gene Editing
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    OriGene clones in human, mouse for NOB1 (see all 6)
    OriGene ORF clones in mouse, rat for NOB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NOB1 (NM_014062)
    Sino Biological Human cDNA Clone for NOB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOB1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NOB1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOB1_HUMAN, Q9ULX3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    NOB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NOB1 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for NOB1):
        Ribosome biogenesis in eukaryotes


    NOB1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOB1
    Interactions:

        Search GeneGlobe Interaction Network for NOB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOB1 (Q9ULX31, 3 ENSP000002688024) via UniProtKB, MINT, STRING, and/or I2D (see all 171)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception IEA--

    NOB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOB1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NOB1 gene: 
    NM_014062.2  

    Unigene Cluster for NOB1:

    NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
    Hs.271695  [show with all ESTs]
    Unigene Representative Sequence: AK126196
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268802(uc002exs.3) ENST00000569871 ENST00000564620 ENST00000561677
    ENST00000563055 ENST00000562416
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NOB1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NOB1:
    hsa-miR-3128
    SwitchGear 3'UTR luciferase reporter plasmidNOB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NOB1
    Predesigned siRNA for gene silencing in human, mouse, rat NOB1
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOB1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NOB1
    OriGene qSTAR qPCR primer pairs in human, mouse for NOB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NOB1
      QuantiTect SYBR Green Assays in human, mouse, rat NOB1
      QuantiFast Probe-based Assays in human, mouse, rat NOB1

    Additional mRNA sequence: 

    AB026125.1 AF190161.1 AK001028.1 AK126196.1 AK314307.1 AY487344.1 BC000050.2 BC064630.1 
    NR_074074.1 

    13 DOTS entries:

    DT.80100673  DT.120678734  DT.101984838  DT.97780613  DT.100818147  DT.92446033  DT.100818156  DT.97864342 
    DT.120678748  DT.92035008  DT.95358340  DT.99990128  DT.92446041 

    Selected AceView cDNA sequences (see all 410):

    CR599606 BM558278 AA339272 NM_014062 AB026125 CA414332 AI074178 BU556843 
    CR619268 AI720545 AI953795 AY487344 CF528483 BX103186 BM724762 H04095 
    BC064630 CR595115 BM792783 BQ574438 CD364836 AL517634 BQ217654 BX443623 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NOB1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                  -                     
    SP2:                                                                        
    SP3:                                                                        


    ECgene alternative splicing isoforms for NOB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTAGATT
    NOB1 Expression
    About this image

    NOB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.271695

    UniProtKB/Swiss-Prot: NOB1_HUMAN, Q9ULX3
    Tissue specificity: Detected in liver, lung, placenta, endothelial cells and spleen

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NOB1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nob11 , 5 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)1, 5 85.82(n)1
    89.55(a)1
      8 (54.12 cM)5
    676191  NM_026277.31  NP_080553.11 
     1074124865 
    chicken
    (Gallus gallus)
    Aves NOB11 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 69.58(n)
    66.75(a)
      415867  XM_414227.4  XP_414227.2 
    lizard
    (Anolis carolinensis)
    Reptilia NOB16
    NIN1/RPN12 binding protein 1 homolog (S. cerevisia...
    58(a)
    1 ↔ 1
    GL343643.1(158729-173007)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3987012 nin one binding protein 75.14(n)    AY341887.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc27e052 Danio rerio cDNA clone IMAGE6795459, partial cds 75.16(n)    BC056558.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29721 CG2972 54.1(n)
    45.79(a)
      31943  NM_132375.2  NP_572603.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y54E10BR.41 CELE_Y54E10BR.4 47.97(n)
    37.68(a)
      171874  NM_058689.3  NP_491090.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NOB1(YOR056C)4
    NOB11
    Essential nuclear protein involved in proteasome maturation more4
    NOB11
    42.88(n)1
    32.55(a)1
      15(431626-430247)4
    8542211, 4  NP_014699.11, 4 


    ENSEMBL Gene Tree for NOB1 (if available)
    TreeFam Gene Tree for NOB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NOB1 gene

    NOB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NOB1
    PGOHUM00000246087


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOB1 (see all 420)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867931011,2
    --69775357(+) CTTACC/TTCTTG 2 -- ds50010--------
    rs99385521,2
    C,F,H--69775364(+) CTTGTA/GGCTCA 2 -- ds50018Minor allele frequency- G:0.00NS EA NA 888
    rs1452894381,2
    --69775383(+) CGAAAA/TAACAG 2 -- ds50010--------
    rs1509952851,2
    C--69775392(+) AGCAGC/TCGTAC 2 -- ds50010--------
    rs1915861121,2
    --69775466(+) TCATAA/GCTCTT 2 -- ds50010--------
    rs1395699131,2
    --69775473(+) TCTTCA/GCAATG 2 -- ds50010--------
    rs172994781,2
    C,F,H--69775500(+) AAGAAC/TGAACT 2 -- ds500127Minor allele frequency- T:0.11NA EA NS 2712
    rs1831521861,2
    C--69775620(+) CTAGAC/GGACTC 2 -- ds50010--------
    rs1864357931,2
    --69775629(+) TCATAC/GTTTGT 2 -- ds50010--------
    rs169591431,2
    C,F--69775638(+) GTGACT/CGTGTG 2 -- ds50013Minor allele frequency- C:0.01NA 142

    HapMap Linkage Disequilibrium report for NOB1 (69775770 - 69788843 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NOB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524364CNV Loss19592680
    nsv906823CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOB1
    DNA2.0 Custom Variant and Variant Library Synthesis for NOB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613586    OMIM disorders: --

    7 diseases for NOB1:    
    About MalaCards
    adenocarcinoma    thymoma    ovarian cancer    hepatocellular carcinoma
    malaria    endotheliitis    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for NOB1:
    Thymoma

    NOB1 for disorders           About GeneDecksing


    Export disorders for NOB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOB1 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with NOB1)
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    1. Cloning, expression and characterization of the human NOB1 gene. (PubMed id 16172919)1, 2, 3, 9 Zhang Y....Zhao S. (Mol. Biol. Rep. 2005)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (Genome Res. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Cloning and expression of a new human polypeptide which regulates protein phosphorylation in Escherichia coli. (PubMed id 1791827)1, 2 Daniele A.... Magnani M. (Mol. Cell. Biochem. 1991)
    7. Knockdown of NOB1 expression by RNAi inhibits cellular proliferation and migration in human gliomas. (PubMed id 23911301)1 Wang H....Zhao B. (Gene 2013)
    8. The von Hippel-Lindau protein pVHL inhibits ribosome biogenesis and protein synthesis. (PubMed id 23612971)1 Zhao W.T....Fang J. (J. Biol. Chem. 2013)
    9. Expression of the NOB1 gene and its clinical significance in papillary thyroid carcinoma. (PubMed id 23685895)1 Lin S....Chen G. (J. Int. Med. Res. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28987 HGNC: 29540 AceView: NOB1P Ensembl:ENSG00000141101 euGenes: HUgn28987
    ECgene: NOB1 Kegg: 28987 H-InvDB: NOB1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NOB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOB1 gene:
    Search GeneIP for patents involving NOB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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