Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NOA1 Gene

protein-coding GIFtS: 46
GCID: GC04M057829

nitric oxide associated 1

(Previous name: chromosome 4 open reading frame 14 )
(Previous symbol: C4orf14)

Explore 3 diseases affiliated with
NOA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nitric Oxide Associated 1¹ ²		MAtNOS1¹
C4orf14¹ ² ³		Nitric Oxide Associated-1²
HAtNOS1¹		Nitric Oxide Synthase, Mitochondrial (Putative)²
HNOA1¹		Nitric Oxide-Associated Protein 1²
MGC3232¹		Putative Ortholog Of Arabidopsis Mitochondrial Nitric Oxide Synthase²
Chromosome 4 Open Reading Frame 14¹

External Ids:	HGNC: 28473¹	Entrez Gene: 84273²	Ensembl: ENSG00000084092⁷	OMIM: 614919⁵	UniProtKB: Q8NC60³

Export aliases for NOA1 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NOA1_HUMAN, Q8NC60

Function: Involved in regulation of mitochondrial protein translation and respiration. Plays a role in

mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes.

Binds GTP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_022853.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for NOA1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NOA1 promoter sequence

Search SABiosciences Chromatin IP Primers for NOA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12 Ensembl cytogenetic band: 4q12 HGNC cytogenetic band: 4q12

NOA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOA1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M057829: view genomic region (about GC identifiers)

Start:	57,829,516 bp from pter	End:	57,844,989 bp from pter
Size:	15,474 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NOA1_HUMAN, Q8NC60 (See protein sequence)

Recommended Name: Nitric oxide-associated protein 1

Size: 698 amino acids; 78458 Da

Subunit: Homodimer or multimer (By similarity). Interacts with mitochondrial complex I, DAP3, MRPL12 and MRPS27

Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side

Sequence caution: Sequence=BAC05262.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q8N7L6 Q9BSQ9

Explore the universe of human proteins at neXtProt for NOA1: NX_Q8NC60

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NC60

NOA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_115689.1

ENSEMBL proteins:

ENSP00000264230

Human Recombinant Protein Products for NOA1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NOA1 OriGene Protein Over-expression Lysate: NOA1 OriGene Custom Protein Services for NOA1
	GenScript Custom Purified and Recombinant Proteins Services for NOA1
	Novus Biologicals NOA1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NOA1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005743	mitochondrial inner membrane	--	--
GO:0031314	colocalizes with extrinsic to mitochondrial inner membrane	IDA	19103604

NOA1 for ontologies About GeneDecksing

NOA1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for NOA1
	GenScript Custom Superior Antibodies Services for NOA1
	Novus Biologicals NOA1 Antibodies
	Abcam antibodies for NOA1
	Uscn Antibodies for NOA1
	Search ThermoFisher Antibodies for NOA1

Assay Products for NOA1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NOA1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NOA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NOA1 for domains About GeneDecksing

1 InterPro domain/family:

IPR006073 GTP_binding_domain

Graphical View of Domain Structure for InterPro Entry Q8NC60

ProtoNet protein and cluster: Q8NC60

1 Blocks protein family: IPB002917 GTP-binding protein

UniProtKB/Swiss-Prot: NOA1_HUMAN, Q8NC60

Similarity: Belongs to the NOA1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NOA1_HUMAN, Q8NC60

Function: Involved in regulation of mitochondrial protein translation and respiration. Plays a role in

mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes.

Binds GTP

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IBA	--
GO:0005515	protein binding	IPI	19103604
GO:0005525	GTP binding	IDA	19103604

NOA1 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for NOA1:

Bright nuclei

G0/1 arrest

Increased G1 DNA content

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Noa1):

cellular

embryogenesis

growth/size

mortality/aging

NOA1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Noa1^tm1Tze for NOA1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NOA1

miRNA Products:		OriGene 3'-UTR Clone: NOA1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOA1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NOA1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOA1 (see all 4) OriGene shRNA RFP: NOA1 OriGene siRNA: NOA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOA1
		Sirion Biotech Custom design and validation of potent shRNA sequences against NOA1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NOA1
			Sirion Biotech Customized adenovirus for overexpression of NOA1 Sirion Biotech Customized adenovirus for potent knockdown of NOA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOA1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for NOA1
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NOA1
		Search LifeMap BioReagents cell lines for NOA1
		Sirion Biotech Customized stable knockdown cell line services for NOA1 Sirion Biotech Customized inducible knockdown cell line services for NOA1 Sirion Biotech Customized stable overexpressing cell line services for NOA1 Sirion Biotech Customized inducible overexpressing cell line services for NOA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOA1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NOA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/247 Interacting proteins for NOA1 (Q8NC60^{1, 2, 3} ENSP00000264230⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 247)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AIFM1	O95831²^,³, ENSP00000287295⁴	MINT-64406 MINT-8079030 I2D: score=4 STRING: ENSP00000287295
GRB10	Q13322²^,³, ENSP00000381793⁴	MINT-8256536 I2D: score=2 STRING: ENSP00000381793
DAP3	P51398¹^,², ENSP00000341692⁴	EBI-717871,EBI-355912 MINT-8079030 STRING: ENSP00000341692
HSPA8	P11142²^,³	MINT-63453 I2D: score=5
MPP3	Q13368²^,³	MINT-64792 I2D: score=5

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	IBA	--
GO:0006915	apoptotic process	IEA	--
GO:0010941	regulation of cell death	IMP	19103604
GO:0032543	mitochondrial translation	ISS	--
GO:0042254	ribosome biogenesis	IBA	--

NOA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NOA1
Search CenterWatch for drugs/clinical trials and news about NOA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NOA1 gene:

NM_032313.2

Unigene Cluster for NOA1:

Nitric oxide associated 1

Hs.8715 [show with all ESTs]

Unigene Representative Sequence: AK128696

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000264230(uc003hck.3)

miRNA Products:		OriGene 3'-UTR Clone: NOA1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NOA1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NOA1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOA1 (see all 4) OriGene shRNA RFP: NOA1 OriGene siRNA: NOA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOA1
		Sirion Biotech Custom design and validation of potent shRNA sequences against NOA1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOA1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for NOA1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NOA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOA1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOA1 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat NOA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOA1

Additional cDNA sequence:

AK074953.1 AK098215.1 AK128696.1 BC004894.2

13 DOTS entries:

DT.100811339 DT.454529 DT.100811340 DT.102838759 DT.97844281 DT.121219299 DT.100802083 DT.91709838

DT.91756631 DT.121219217 DT.91756627 DT.95375508 DT.95375514

24/192 AceView cDNA sequences (see all 192):

BU162163 AW161231 AK074953 BM673178 CB118652 AI382760 AA459474 AI018635

BC004894 NM_032313 CR599445 AW026170 AI655999 BM834196 AI086197 AA610047

BU753810 AW136262 BF222539 AI826414 AA459136 AI989433 AA280147 AI125581

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for NOA1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8
SP1:
SP2:

ECgene alternative splicing isoforms for NOA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NOA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGTCATAC

About this image

NOA1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Endochondral Facial Bones

Bone

Bone

Bone

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NOA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NOA1

SOURCE GeneReport for Unigene cluster: Hs.8715

SABiosciences Custom PCR Arrays for NOA1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOA1 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat NOA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NOA1 gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Noa1^{1 , 5}	nitric oxide associated 1^{1, 5}	79.81(n)¹ 76.09(a)¹		5 (41.64 cM)⁵ 56412¹ NM_019836.3¹ NP_062810.1¹ 77294182⁵
chicken (Gallus gallus)	Aves	NOA1¹	nitric oxide associated 1	66.73(n) 58.73(a)		422622 XM_420579.3 XP_420579.3
lizard (Anolis carolinensis)	Reptilia	C4orf14⁶	--	60(a)	1 ↔ 1	GL343257.1(1823240-1842296)
zebrafish (Danio rerio)	Actinopterygii	noa1¹	nitric oxide associated 1	59.92(n) 56.63(a)		564706 NM_001114428.1 NP_001107900.1
fruit fly (Drosophila melanogaster)	Insecta	CG10914¹	CG10914	48.21(n) 39.48(a)		37075 NM_137453.2 NP_611297.3
worm (Caenorhabditis elegans)	Secernentea	Y48E1B.2¹	Protein Y48E1B.2	44.04(n) 33.61(a)		174998 NM_064444.3 NP_496845.1
thale cress (Arabidopsis thaliana)	eudicotyledons	NOA1¹	Nitric oxide synthase 1	40.93(n) 30.56(a)		823899 NM_180335.1 NP_850666.1
rice (Oryza sativa)	Liliopsida	Os02g0104700¹	hypothetical protein	44.42(n) 32.99(a)		4328006 NM_001052149.1 NP_001045614.1

ENSEMBL Gene Tree for NOA1 (if available)
TreeFam Gene Tree for NOA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs36105039^1,2	C	--	57831170(+)	`AGTAA-/TTTTTT`	1	--	int¹		2		NA CSA	4
rs71945292^1,2	C	--	57831860(+)	`GTATG-/GTGT GTGTG`	1	--	int¹		0	--	--	--	--
rs143883938^1,2	C	--	57831860(+)	`GTATG-/GTGTGTGTGT GTGTGTGTGTGTGTGTG`	1	--	int¹		0	--	--	--	--
rs66705955^1,2	C	--	57831864(+)	`TGTGT-/GTGTGT ATTGG`	1	--	int¹		1		NA	2
rs199775585^1,2	--	--	57840818(+)	`GTCTC-/AAAAAAA`	1	--	int¹		0	--	--	--	--
rs35959806^1,2	--	--	57831861(+)	`TGTGT-/TGTG TGTGTGGTGTG`	1	--	int¹		0	--	--	--	--
rs57858828^1,2	--	--	57837482(+)	`AAAAA-/AAGTATG`	1	--	int¹		0	--	--	--	--
rs72272844^1,2	--	--	57831865(+)	`GTGTG-/TGTGTG TGTGT`	1	--	int¹		0	--	--	--	--
rs199764302^1,2	--	--	57831860(+)	`GTATG-/GTGTGTG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NOA1 (57829516 - 57844989 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NOA1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOA1

DNA2.0 Custom Variant and Variant Library Synthesis for NOA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NOA1 for disorders           About GeneDecksing

OMIM gene information: 614919    OMIM disorders: --

3 diseases for NOA1:    About MalaCards

pneumonia adenocarcinoma malaria

Export disorders for NOA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NOA1 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with NOA1)

Utopia: connect your pdf to the dynamic
world of online information

Human C4orf14 interacts with the mitochondrial nucleoi d and is involved in the biogenesis of the small mitochondrial ribosomal subunit . (PubMed id 22447445)^{1, 3} He J....Holt I.J. (2012)
Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes. (PubMed id 21771794)^{1, 3} Heidler J....Szibor M. (2011)
hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PubMed id 19103604)^{1, 2} Tang T....Farquhar M.G. (2009)
Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate. (PubMed id 16380119)^{1, 3} Zemojtel T....Mundlos S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Studies of an 800-kilobase DNA stretch of the Drosoph ila X chromosome: comapping of a subclass of scaffold-attached regions with seq uences able to replicate autonomously in Saccharomyces cerevisiae. (PubMed id 2118999)^{1, 3} Brun C....Miassod R. (1990)
NOA1 is an essential GTPase required for mitochondria l protein synthesis. (PubMed id 21118999)¹ Kolanczyk M....Mundlos S. (2011)
Genome-wide association study identifies two susceptib ility loci for exudative age-related macular degeneration in the Japanese popula tion. (PubMed id 21909106)¹ Arakawa S....Kubo M. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84273	HGNC: 28473	AceView: C4orf14	Ensembl:ENSG00000084092	euGenes: HUgn84273
ECgene: NOA1	H-InvDB: NOA1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NOA1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NOA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NOA1 gene:
Search GeneIP for patents involving NOA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for NOA1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NOA1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NOA1
	OriGene Protein Over-expression Lysate for NOA1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for NOA1		OriGene 3'-UTR Clone for NOA1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NOA1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NOA1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for NOA1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NOA1		OriGene Custom Protein Services for NOA1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NOA1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NOA1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NOA1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NOA1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NOA1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NOA1

	GenScript Custom Purified and Recombinant Proteins Services for NOA1		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NOA1
	GenScript Custom Assay Services for NOA1		GenScript Custom Superior Antibodies Services for NOA1
	GenScript Custom overexpressing Cell Line Services for NOA1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for NOA1
	Search Chromatin IP Primers for NOA1
	Search RT² qPCR Primer Assays in human, mouse, rat NOA1
	Search GNC Networks for NOA1
	SABiosciences Custom PCR Arrays for NOA1

Search Tocris compounds for NOA1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NOA1 antibodies
	NOA1 lysates

	Antibodies for NOA1
	See all of Abcam's Antibodies, Kits and Proteins for NOA1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

NOA1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for NOA1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOA1

	Browse SwitchGear 3'UTR luciferase reporter plasmids for NOA1
	SwitchGear Promoter luciferase reporter plasmids for NOA1

Search ThermoFisher Antibodies for NOA1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NOA1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NOA1

Sirion Biotech Customized:

	stable knockdown cell line services for NOA1
	inducible knockdown cell line services for NOA1
	design and validation of potent shRNA sequences against NOA1
	adenovirus for potent knockdown of NOA1
	adenovirus for overexpression of NOA1
	stable overexpressing cell line services for NOA1
	inducible overexpressing cell line services for NOA1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NOA1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

NOA1 Gene

nitric oxide associated 1

Aliases
for NOA1 gene

Summaries
for NOA1 gene

Genomic Views
for NOA1 gene

Proteins
for NOA1 gene

Protein Domains /
Families
for NOA1 gene

Function
for NOA1 gene

Pathways & Interactions
for NOA1 gene

Drugs & Compounds
for NOA1 gene

Transcripts
for NOA1 gene

Expression
for NOA1 gene

Orthologs
for NOA1 gene

Paralogs
for NOA1 gene

Genomic Variants
for NOA1 gene

Disorders / Diseases
for NOA1 gene

Publications
for NOA1 gene

External Searches for NOA1 gene

Genome Databases showing NOA1 gene

Other Databases showing NOA1 gene

Specialized Databases showing NOA1 gene

Intellectual Property
for NOA1 gene

Products
for NOA1 gene

View Random Gene

Advanced Search

Export list of displayed genes

NOA1 Gene

nitric oxide associated 1

Aliasesfor NOA1 gene

Summariesfor NOA1 gene

Genomic Viewsfor NOA1 gene

Proteinsfor NOA1 gene

Protein Domains /Familiesfor NOA1 gene

Functionfor NOA1 gene

Pathways & Interactionsfor NOA1 gene

Drugs & Compoundsfor NOA1 gene

Transcriptsfor NOA1 gene

Expression for NOA1 gene

Orthologsfor NOA1 gene

Paralogsfor NOA1 gene

Genomic Variantsfor NOA1 gene

Disorders / Diseasesfor NOA1 gene

Publicationsfor NOA1 gene

External Searches for NOA1 gene

Genome Databases showing NOA1 gene

Other Databases showing NOA1 gene

Specialized Databases showing NOA1 gene

Intellectual Propertyfor NOA1 gene

Productsfor NOA1 gene

View Random Gene

Aliases
for NOA1 gene

Summaries
for NOA1 gene

Genomic Views
for NOA1 gene

Proteins
for NOA1 gene

Protein Domains /
Families
for NOA1 gene

Function
for NOA1 gene

Pathways & Interactions
for NOA1 gene

Drugs & Compounds
for NOA1 gene

Transcripts
for NOA1 gene

Expression
for NOA1 gene

Orthologs
for NOA1 gene

Paralogs
for NOA1 gene

Genomic Variants
for NOA1 gene

Disorders / Diseases
for NOA1 gene

Publications
for NOA1 gene

Intellectual Property
for NOA1 gene

Products
for NOA1 gene