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NOA1 Gene

protein-coding   GIFtS: 48
GCID: GC04M057829

Nitric Oxide Associated 1

(Previous name: chromosome 4 open reading frame 14)
(Previous symbol: C4orf14)
  Search for NOA1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nitric Oxide Associated 11 2     hNOA12
C4orf141 2 3 5     mAtNOS12
Chromosome 4 Open Reading Frame 141     Mitochondrial GTPase 3 Homolog2
Mitochondrial (Putative)1     Nitric Oxide Associated-12
Mitochondrial GTPase 3 Homolog (S. Cerevisiae)1     Nitric Oxide Synthase, Mitochondrial (Putative)2
Nitric Oxide Synthase1     Nitric Oxide-Associated Protein 12
MTG32     Putative Ortholog Of Arabidopsis Mitochondrial Nitric Oxide Synthase2
hAtNOS12     

External Ids:    HGNC: 284731   Entrez Gene: 842732   Ensembl: ENSG000000840927   OMIM: 6149195   UniProtKB: Q8NC603   

Export aliases for NOA1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NOA1 Gene:
NOA1 (nitric oxide associated 1) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot: NOA1_HUMAN, Q8NC60
Function: Involved in regulation of mitochondrial protein translation and respiration. Plays a role in
mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain
supercomplexes. Binds GTP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_022853.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NOA1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNOA1 promoter sequence
   Search Chromatin IP Primers for NOA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NOA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

NOA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOA1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M057829:  view genomic region     (about GC identifiers)

Start:
57,829,516 bp from pter      End:
57,844,989 bp from pter
Size:
15,474 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NOA1_HUMAN, Q8NC60 (See protein sequence)
Recommended Name: Nitric oxide-associated protein 1  
Size: 698 amino acids; 78458 Da
Subunit: Homodimer or multimer (By similarity). Interacts with mitochondrial complex I, DAP3, MRPL12 and MRPS27
Sequence caution: Sequence=BAC05262.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8N7L6 Q9BSQ9

Explore the universe of human proteins at neXtProt for NOA1: NX_Q8NC60

Explore proteomics data for NOA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys89
  • Modification sites at PhosphoSitePlus

  • See NOA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115689.1  
    ENSEMBL proteins: 
     ENSP00000264230  

    NOA1 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for NOA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006073 GTP_binding_domain
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q8NC60

    ProtoNet protein and cluster: Q8NC60

    1 Blocks protein domain: IPB002917 GTP-binding protein

    UniProtKB/Swiss-Prot: NOA1_HUMAN, Q8NC60
    Similarity: Belongs to the NOA1 family


    Find genes that share domains with NOA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NOA1_HUMAN, Q8NC60
    Function: Involved in regulation of mitochondrial protein translation and respiration. Plays a role in
    mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain
    supercomplexes. Binds GTP

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IBA--
    GO:0005515protein binding IPI19103604
    GO:0005525GTP binding IDA19103604
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NOA1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NOA1:
     Bright nuclei  G0/1 arrest  Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Noa1):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with NOA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Noa1tm1Tze for NOA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NOA1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NOA1

    miRNA
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    miRTarBase miRNAs that target NOA1:
    hsa-mir-197-3p (MIRT048148)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NOA1_HUMAN, Q8NC60: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane ----
    GO:0031314colocalizes with extrinsic component of mitochondrial inner membrane IDA19103604

    Find genes that share ontologies with NOA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NOA1
    Interactions:

        Search GeneGlobe Interaction Network for NOA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NOA1 (Q8NC601, 2, 3 ENSP000002642304) via UniProtKB, MINT, STRING, and/or I2D (see all 305)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AIFM1O958312, 3, ENSP000002872954MINT-64406 MINT-8079030 I2D: score=4 STRING: ENSP00000287295
    GRB10Q133222, 3, ENSP000003817934MINT-8256536 I2D: score=2 STRING: ENSP00000381793
    DAP3P513981, 2, ENSP000003416924EBI-717871,EBI-355912 MINT-8079030 STRING: ENSP00000341692
    HSPA8P111422, 3MINT-63453 I2D: score=5 
    MPP3Q133682, 3MINT-64792 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IBA--
    GO:0006915apoptotic process IEA--
    GO:0010941regulation of cell death IMP19103604
    GO:0032543mitochondrial translation ISS--
    GO:0042254ribosome biogenesis IBA--

    Find genes that share ontologies with NOA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NOA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NOA1 gene: 
    NM_032313.2  

    Unigene Cluster for NOA1:

    Nitric oxide associated 1
    Hs.8715  [show with all ESTs]
    Unigene Representative Sequence: AK128696
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000264230(uc003hck.3)
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NOA1
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NOA1
      QuantiFast Probe-based Assays in human, mouse, rat NOA1

    Additional mRNA sequence: 

    AK074953.1 AK098215.1 AK128696.1 BC004894.2 

    13 DOTS entries:

    DT.100811339  DT.454529  DT.100811340  DT.102838759  DT.97844281  DT.121219299  DT.100802083  DT.91709838 
    DT.91756631  DT.121219217  DT.91756627  DT.95375508  DT.95375514 

    Selected AceView cDNA sequences (see all 192):

    AW136262 CB118652 AA459474 AA610047 BM834196 AA459153 CA430979 BC004894 
    BU753810 BI870123 AW026170 AI826414 BF222539 BU162163 BM673178 AA459136 
    CR599445 AI382760 NM_032313 AK074953 AA336731 AW161231 AI125581 AI018635 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NOA1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                            
    SP2:                                                            


    ECgene alternative splicing isoforms for NOA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NOA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGTCATAC
    NOA1 Expression
    About this image


    NOA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Endochondral Facial Bones
     
     Limb (Muscoskeletal System)
             Pelvic Girdle
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
    NOA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NOA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8715
        Custom PCR Arrays for NOA1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NOA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NOA1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Noa11 , 5 nitric oxide associated 11, 5 79.81(n)1
    76.09(a)1
      5 (41.64 cM)5
    564121  NM_019836.31  NP_062810.11 
     772941825 
    chicken
    (Gallus gallus)
    Aves NOA11 nitric oxide associated 1 67.29(n)
    59.59(a)
      422622  XM_420579.4  XP_420579.4 
    lizard
    (Anolis carolinensis)
    Reptilia NOA16
    nitric oxide associated 1
    57(a)
    1 ↔ 1
    GL343257.1(1823228-1844759)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia noa11 nitric oxide associated 1 59.89(n)
    61.19(a)
      100488516  XM_002937553.2  XP_002937599.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018835631 nitric oxide-associated protein 1-like 66.38(n)
    59.57(a)
      101883563  XM_005174655.1  XP_005174712.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG109141 CG10914 48.08(n)
    39.68(a)
      37075  NM_137453.3  NP_611297.3 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48E1B.21 Y48E1B.2 45.29(n)
    34.94(a)
      174998  NM_064444.3  NP_496845.1 


    ENSEMBL Gene Tree for NOA1 (if available)
    TreeFam Gene Tree for NOA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NOA1 (see all 336)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355004
    A breast cancer sample4--see VAR_0355002 Q R mis40--------
    rs712089611,2
    C--57733982(+) AAAAA-/A/GGAAAC 1 -- int11NA 2
    rs789894531,2
    C,F--57734034(+) TATATA/GTATGT 1 -- int13Minor allele frequency- G:0.22WA CSA 122
    rs1152399381,2
    C,F--57734069(+) ATACTA/GTACAA 1 -- int11Minor allele frequency- G:0.03NA 120
    rs100326251,2
    C,F--57734178(+) CGCGGT/CGGCTC 1 -- int112Minor allele frequency- C:0.08NA WA CSA EA 258
    rs1419614021,2
    --57734197(+) ATTCCC/TAGCAC 1 -- int10--------
    rs1132547401,2
    C--57734219(+) GAGGCG/AGATGG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1385673441,2
    --57734245(+) GAGTTC/GGAGAC 1 -- int10--------
    rs1847315051,2
    --57734333(+) ATCCCA/GGCTAC 1 -- int10--------
    rs3743077821,2
    C--57734401(+) AAGATC/TTGCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NOA1 (57829516 - 57844989 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NOA1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NOA1
    DNA2.0 Custom Variant and Variant Library Synthesis for NOA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614919    OMIM disorders: --


    Find genes that share disorders with NOA1           About GenesLikeMe


    Export disorders for NOA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NOA1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with NOA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit. (PubMed id 22447445)1, 3 He J....Holt I.J. (Nucleic Acids Res. 2012)
    2. Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes. (PubMed id 21771794)1, 3 Heidler J....Szibor M. (J. Biol. Chem. 2011)
    3. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PubMed id 19103604)1, 2 Tang T....Farquhar M.G. (J. Biol. Chem. 2009)
    4. Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate. (PubMed id 16380119)1, 3 Zemojtel T....Mundlos S. (FEBS Lett. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Studies of an 800-kilobase DNA stretch of the Drosophila X chromosome: comapping of a subclass of scaffold-attached regions with sequences able to replicate autonomously in Saccharomyces cerevisiae. (PubMed id 2118999)1, 3 Brun C....Miassod R. (Mol. Cell. Biol. 1990)
    8. NOA1 is an essential GTPase required for mitochondrial protein synthesis. (PubMed id 21118999)1 Kolanczyk M....Mundlos S. (Mol. Biol. Cell 2011)
    9. Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. (PubMed id 21909106)1 Arakawa S....Kubo M. (Nat. Genet. 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84273 HGNC: 28473 AceView: C4orf14 Ensembl:ENSG00000084092 euGenes: HUgn84273
    ECgene: NOA1 H-InvDB: NOA1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NOA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NOA1 gene:
    Search GeneIP for patents involving NOA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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