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Aliases for NOA1 Gene

Aliases for NOA1 Gene

  • Nitric Oxide Associated 1 2 3
  • C4orf14 3 4 6
  • Putative Ortholog Of Arabidopsis Mitochondrial Nitric Oxide Synthase 3
  • Nitric Oxide Synthase, Mitochondrial (Putative) 3
  • Mitochondrial GTPase 3 Homolog (S. Cerevisiae) 2
  • Chromosome 4 Open Reading Frame 14 2
  • Nitric Oxide-Associated Protein 1 3
  • Mitochondrial GTPase 3 Homolog 3
  • Nitric Oxide Associated-1 3
  • Mitochondrial (Putative) 2
  • Nitric Oxide Synthase 2
  • HAtNOS1 3
  • MAtNOS1 3
  • HNOA1 3
  • MTG3 3

External Ids for NOA1 Gene

Previous HGNC Symbols for NOA1 Gene

  • C4orf14

Previous GeneCards Identifiers for NOA1 Gene

  • GC04M057829

Summaries for NOA1 Gene

GeneCards Summary for NOA1 Gene

NOA1 (Nitric Oxide Associated 1) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for NOA1 Gene

  • Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOA1 Gene

Genomics for NOA1 Gene

Genomic Location for NOA1 Gene

56,963,350 bp from pter
56,978,823 bp from pter
15,474 bases
Minus strand

Genomic View for NOA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NOA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOA1 Gene

No data available for Regulatory Elements for NOA1 Gene

Proteins for NOA1 Gene

  • Protein details for NOA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nitric oxide-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8N7L6
    • Q9BSQ9

    Protein attributes for NOA1 Gene

    698 amino acids
    Molecular mass:
    78458 Da
    Quaternary structure:
    • Homodimer or multimer (By similarity). Interacts with mitochondrial complex I, DAP3, MRPL12 and MRPS27.
    • Sequence=BAC05262.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NOA1 Gene

Proteomics data for NOA1 Gene at MOPED

Post-translational modifications for NOA1 Gene

  • Ubiquitination at Lys89
  • Modification sites at PhosphoSitePlus

Other Protein References for NOA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOA1 Gene

Domains for NOA1 Gene

Protein Domains for NOA1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8NC60
  • Contains 1 CP-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. NOA1 subfamily.
genes like me logo Genes that share domains with NOA1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NOA1 Gene

Function for NOA1 Gene

Molecular function for NOA1 Gene

UniProtKB/Swiss-Prot Function: Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.

Gene Ontology (GO) - Molecular Function for NOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 19103604
GO:0005525 GTP binding IDA 19103604
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NOA1: view
genes like me logo Genes that share phenotypes with NOA1: view

Animal Models for NOA1 Gene

MGI Knock Outs for NOA1:

miRNA for NOA1 Gene

miRTarBase miRNAs that target NOA1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NOA1 Gene

Localization for NOA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOA1 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Gene Ontology (GO) - Cellular Components for NOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane --
GO:0031314 colocalizes_with extrinsic component of mitochondrial inner membrane IDA 19103604
genes like me logo Genes that share ontologies with NOA1: view

No data available for Subcellular locations from COMPARTMENTS for NOA1 Gene

Pathways for NOA1 Gene

SuperPathways for NOA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006915 apoptotic process IEA --
GO:0010941 regulation of cell death IMP 19103604
GO:0032543 mitochondrial translation ISS --
GO:0042254 ribosome biogenesis IBA --
genes like me logo Genes that share ontologies with NOA1: view

No data available for Pathways by source for NOA1 Gene

Transcripts for NOA1 Gene

mRNA/cDNA for NOA1 Gene

(192) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOA1 Gene

Nitric oxide associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOA1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8

Relevant External Links for NOA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NOA1 Gene

mRNA expression in normal human tissues for NOA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOA1 Gene

SOURCE GeneReport for Unigene cluster for NOA1 Gene Hs.8715

genes like me logo Genes that share expressions with NOA1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NOA1 Gene

Orthologs for NOA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NOA1 35
  • 99.47 (n)
  • 99.43 (a)
NOA1 36
  • 99 (a)
(Bos Taurus)
Mammalia NOA1 35
  • 82.44 (n)
  • 76.91 (a)
NOA1 36
  • 77 (a)
(Canis familiaris)
Mammalia NOA1 35
  • 85.22 (n)
  • 78.49 (a)
NOA1 36
  • 78 (a)
(Mus musculus)
Mammalia Noa1 35
  • 79.81 (n)
  • 76.09 (a)
Noa1 16
Noa1 36
  • 75 (a)
(Monodelphis domestica)
Mammalia NOA1 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia NOA1 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Noa1 35
  • 79.14 (n)
  • 76.19 (a)
(Gallus gallus)
Aves NOA1 35
  • 67.29 (n)
  • 59.59 (a)
NOA1 36
  • 50 (a)
(Anolis carolinensis)
Reptilia NOA1 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia noa1 35
  • 59.89 (n)
  • 61.19 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4079 35
(Danio rerio)
Actinopterygii LOC101883563 35
  • 66.38 (n)
  • 59.57 (a)
noa1 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010271 35
  • 47.67 (n)
  • 41.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10914 35
  • 48.08 (n)
  • 39.68 (a)
CG10914 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea Y48E1B.2 35
  • 45.29 (n)
  • 34.94 (a)
Y48E1B.2 36
  • 23 (a)
Species with no ortholog for NOA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOA1 Gene

Gene Tree for NOA1 (if available)
Gene Tree for NOA1 (if available)

Paralogs for NOA1 Gene

No data available for Paralogs for NOA1 Gene

Variants for NOA1 Gene

Sequence variations from dbSNP and Humsavar for NOA1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs781664 -- 56,971,897(-) aaaaa(A/G)aaaaa intron-variant
rs781665 -- 56,965,295(-) CCAAG(C/T)GCAGT intron-variant
rs781666 -- 56,964,815(-) GAGGA(C/T)TCTAA intron-variant
rs813623 -- 56,971,176(+) ggtgt(A/G)gtggc intron-variant
rs1107674 -- 56,972,524(+) GAGAC(G/T)ATTCA intron-variant

Relevant External Links for NOA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NOA1 Gene

Disorders for NOA1 Gene

No disorders were found for NOA1 Gene.

No data available for UniProtKB/Swiss-Prot for NOA1 Gene

Publications for NOA1 Gene

  1. Studies of an 800-kilobase DNA stretch of the Drosophila X chromosome: comapping of a subclass of scaffold-attached regions with sequences able to replicate autonomously in Saccharomyces cerevisiae. (PMID: 2118999) Brun C. … Miassod R. (Mol. Cell. Biol. 1990) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PMID: 19103604) Tang T. … Farquhar M.G. (J. Biol. Chem. 2009) 3 4
  5. Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes. (PMID: 21771794) Heidler J. … Szibor M. (J. Biol. Chem. 2011) 2 3

Products for NOA1 Gene

Sources for NOA1 Gene

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