Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NOA1 Gene

Aliases for NOA1 Gene

  • Nitric Oxide Associated 1 2 3 5
  • C4orf14 3 4
  • Putative Ortholog Of Arabidopsis Mitochondrial Nitric Oxide Synthase 3
  • Nitric Oxide Synthase, Mitochondrial (Putative) 3
  • Mitochondrial GTPase 3 Homolog (S. Cerevisiae) 2
  • Chromosome 4 Open Reading Frame 14 2
  • Mitochondrial GTPase 3 Homolog 3
  • Nitric Oxide Associated-1 3
  • Mitochondrial (Putative) 2
  • Nitric Oxide Synthase 2
  • HAtNOS1 3
  • MAtNOS1 3
  • HNOA1 3
  • MTG3 3

External Ids for NOA1 Gene

Previous HGNC Symbols for NOA1 Gene

  • C4orf14

Previous GeneCards Identifiers for NOA1 Gene

  • GC04M057829

Summaries for NOA1 Gene

Entrez Gene Summary for NOA1 Gene

  • The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015]

GeneCards Summary for NOA1 Gene

NOA1 (Nitric Oxide Associated 1) is a Protein Coding gene. Diseases associated with NOA1 include sarcomatosis and macular degeneration, age-related, 1. GO annotations related to this gene include poly(A) RNA binding and GTPase activity.

UniProtKB/Swiss-Prot for NOA1 Gene

  • Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NOA1 Gene

Genomics for NOA1 Gene

Regulatory Elements for NOA1 Gene

Promoters for NOA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NOA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NOA1 Gene

Chromosome:
4
Start:
56,963,350 bp from pter
End:
56,978,823 bp from pter
Size:
15,474 bases
Orientation:
Minus strand

Genomic View for NOA1 Gene

Genes around NOA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NOA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NOA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NOA1 Gene

Proteins for NOA1 Gene

  • Protein details for NOA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC60-NOA1_HUMAN
    Recommended name:
    Nitric oxide-associated protein 1
    Protein Accession:
    Q8NC60
    Secondary Accessions:
    • Q8N7L6
    • Q9BSQ9

    Protein attributes for NOA1 Gene

    Size:
    698 amino acids
    Molecular mass:
    78458 Da
    Quaternary structure:
    • Homodimer or multimer (By similarity). Interacts with mitochondrial complex I, DAP3, MRPL12 and MRPS27.
    SequenceCaution:
    • Sequence=BAC05262.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NOA1 Gene

Proteomics data for NOA1 Gene at MOPED

Post-translational modifications for NOA1 Gene

  • Ubiquitination at Lys 89
  • Modification sites at PhosphoSitePlus

Other Protein References for NOA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NOA1 Gene

Domains & Families for NOA1 Gene

Protein Domains for NOA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NC60

UniProtKB/Swiss-Prot:

NOA1_HUMAN :
  • Contains 1 CP-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. NOA1 subfamily.
Domain:
  • Contains 1 CP-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class YlqF/YawG GTPase family. NOA1 subfamily.
genes like me logo Genes that share domains with NOA1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NOA1 Gene

Function for NOA1 Gene

Molecular function for NOA1 Gene

UniProtKB/Swiss-Prot Function:
Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP.

Gene Ontology (GO) - Molecular Function for NOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19103604
genes like me logo Genes that share ontologies with NOA1: view
genes like me logo Genes that share phenotypes with NOA1: view

Animal Models for NOA1 Gene

MGI Knock Outs for NOA1:

Animal Model Products

miRNA for NOA1 Gene

miRTarBase miRNAs that target NOA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NOA1 Gene

Localization for NOA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NOA1 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NOA1 Gene COMPARTMENTS Subcellular localization image for NOA1 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
chloroplast 1
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for NOA1 Gene

Pathways & Interactions for NOA1 Gene

SuperPathways for NOA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032543 mitochondrial translation IEA,ISS --
genes like me logo Genes that share ontologies with NOA1: view

No data available for Pathways by source and SIGNOR curated interactions for NOA1 Gene

Drugs & Compounds for NOA1 Gene

No Compound Related Data Available

Transcripts for NOA1 Gene

mRNA/cDNA for NOA1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(192) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NOA1 Gene

Nitric oxide associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NOA1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:

Relevant External Links for NOA1 Gene

GeneLoc Exon Structure for
NOA1
ECgene alternative splicing isoforms for
NOA1

Expression for NOA1 Gene

mRNA expression in normal human tissues for NOA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NOA1 Gene

This gene is overexpressed in Lung (24.1), Plasma (22.0), Breast (8.6), and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NOA1 Gene



SOURCE GeneReport for Unigene cluster for NOA1 Gene Hs.8715

genes like me logo Genes that share expression patterns with NOA1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NOA1 Gene

Orthologs for NOA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NOA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NOA1 35
  • 82.44 (n)
  • 76.91 (a)
NOA1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NOA1 35
  • 85.22 (n)
  • 78.49 (a)
NOA1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Noa1 35
  • 79.81 (n)
  • 76.09 (a)
Noa1 16
Noa1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NOA1 35
  • 99.47 (n)
  • 99.43 (a)
NOA1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Noa1 35
  • 79.14 (n)
  • 76.19 (a)
oppossum
(Monodelphis domestica)
Mammalia NOA1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NOA1 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves NOA1 35
  • 67.29 (n)
  • 59.59 (a)
NOA1 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NOA1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia noa1 35
  • 59.89 (n)
  • 61.19 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101883563 35
  • 66.38 (n)
  • 59.57 (a)
noa1 36
  • 45 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4079 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010271 35
  • 47.67 (n)
  • 41.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10914 35
  • 48.08 (n)
  • 39.68 (a)
CG10914 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y48E1B.2 35
  • 45.29 (n)
  • 34.94 (a)
Y48E1B.2 36
  • 23 (a)
OneToOne
Species with no ortholog for NOA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NOA1 Gene

ENSEMBL:
Gene Tree for NOA1 (if available)
TreeFam:
Gene Tree for NOA1 (if available)

Paralogs for NOA1 Gene

No data available for Paralogs for NOA1 Gene

Variants for NOA1 Gene

Sequence variations from dbSNP and Humsavar for NOA1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_025941 -
rs11553077 - 56,973,314(-) ACAGA(A/G)GGATA reference, missense
VAR_035500 A breast cancer sample
rs781664 -- 56,971,897(-) aaaaa(A/G)aaaaa intron-variant
rs781665 -- 56,965,295(-) CCAAG(C/T)GCAGT intron-variant

Variation tolerance for NOA1 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.97; 74.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NOA1 Gene

HapMap Linkage Disequilibrium report
NOA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NOA1 Gene

Disorders for NOA1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NOA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sarcomatosis
  • sarcomatosis nos
macular degeneration, age-related, 1
  • macular degeneration, age-related, 2
- elite association - COSMIC cancer census association via MalaCards
Search NOA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NOA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NOA1
genes like me logo Genes that share disorders with NOA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NOA1 Gene

Publications for NOA1 Gene

  1. Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit. (PMID: 22447445) He J. … Holt I.J. (Nucleic Acids Res. 2012) 2 3 67
  2. Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes. (PMID: 21771794) Heidler J. … Szibor M. (J. Biol. Chem. 2011) 2 3
  3. Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate. (PMID: 16380119) Zemojtel T. … Mundlos S. (FEBS Lett. 2006) 2 3
  4. Studies of an 800-kilobase DNA stretch of the Drosophila X chromosome: comapping of a subclass of scaffold-attached regions with sequences able to replicate autonomously in Saccharomyces cerevisiae. (PMID: 2118999) Brun C. … Miassod R. (Mol. Cell. Biol. 1990) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NOA1 Gene

Sources for NOA1 Gene

Back to Top

Content