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Aliases for NNMT Gene

Aliases for NNMT Gene

  • Nicotinamide N-Methyltransferase 2 3 5
  • EC 2.1.1.1 4

External Ids for NNMT Gene

Previous GeneCards Identifiers for NNMT Gene

  • GC11P116520
  • GC11P115640
  • GC11P114162
  • GC11P113666
  • GC11P113633
  • GC11P110095

Summaries for NNMT Gene

Entrez Gene Summary for NNMT Gene

  • N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]

GeneCards Summary for NNMT Gene

NNMT (Nicotinamide N-Methyltransferase) is a Protein Coding gene. Diseases associated with NNMT include parkinson disease, late-onset. Among its related pathways are Metabolism and NAD metabolism. GO annotations related to this gene include methyltransferase activity and nicotinamide N-methyltransferase activity. An important paralog of this gene is PNMT.

UniProtKB/Swiss-Prot for NNMT Gene

  • Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

Gene Wiki entry for NNMT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NNMT Gene

Genomics for NNMT Gene

Regulatory Elements for NNMT Gene

Enhancers for NNMT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NNMT on UCSC Golden Path with GeneCards custom track

Genomic Location for NNMT Gene

Chromosome:
11
Start:
114,257,787 bp from pter
End:
114,313,285 bp from pter
Size:
55,499 bases
Orientation:
Plus strand

Genomic View for NNMT Gene

Genes around NNMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NNMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NNMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NNMT Gene

Proteins for NNMT Gene

  • Protein details for NNMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40261-NNMT_HUMAN
    Recommended name:
    Nicotinamide N-methyltransferase
    Protein Accession:
    P40261

    Protein attributes for NNMT Gene

    Size:
    264 amino acids
    Molecular mass:
    29574 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NNMT Gene

neXtProt entry for NNMT Gene

Proteomics data for NNMT Gene at MOPED

Post-translational modifications for NNMT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NNMT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NNMT Gene

Domains & Families for NNMT Gene

Suggested Antigen Peptide Sequences for NNMT Gene

Graphical View of Domain Structure for InterPro Entry

P40261

UniProtKB/Swiss-Prot:

NNMT_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
genes like me logo Genes that share domains with NNMT: view

No data available for Gene Families for NNMT Gene

Function for NNMT Gene

Molecular function for NNMT Gene

GENATLAS Biochemistry:
nicotinamide N-methyltransferase
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
UniProtKB/Swiss-Prot Function:
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

Enzyme Numbers (IUBMB) for NNMT Gene

genes like me logo Genes that share phenotypes with NNMT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NNMT

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NNMT Gene

Localization for NNMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NNMT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NNMT Gene COMPARTMENTS Subcellular localization image for NNMT gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NNMT Gene

Pathways & Interactions for NNMT Gene

genes like me logo Genes that share pathways with NNMT: view

Pathways by source for NNMT Gene

1 GeneGo (Thomson Reuters) pathway for NNMT Gene

Interacting Proteins for NNMT Gene

Gene Ontology (GO) - Biological Process for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010243 response to organonitrogen compound IEA --
GO:0031100 organ regeneration IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NNMT: view

No data available for SIGNOR curated interactions for NNMT Gene

Drugs & Compounds for NNMT Gene

(6) Drugs for NNMT Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist, Target, binder 854,854
S-Adenosylmethionine Approved Nutra 0
Nicotinamide Experimental Nutra 850,854
s-adenosylhomocysteine Experimental Pharma 0
ARI-3037MO Pharma inhibitor, agonist 0

(9) Additional Compounds for NNMT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Methylnicotinamide
  • 1-Methyl-3-carbamoylpyridinium
  • 1-Methyl-3-carbamoylpyridinium cation
  • 1-Methylnicotinamide
  • 3-Amido-N-methylpyridinium: 1-methyl-3-Pyridinecarboxamide
  • 3-Carbamoyl-1-methyl-Pyridinium
3106-60-3
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with NNMT: view

Transcripts for NNMT Gene

Unigene Clusters for NNMT Gene

Nicotinamide N-methyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NNMT Gene

No ASD Table

Relevant External Links for NNMT Gene

GeneLoc Exon Structure for
NNMT
ECgene alternative splicing isoforms for
NNMT

Expression for NNMT Gene

mRNA expression in normal human tissues for NNMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NNMT Gene

This gene is overexpressed in Liver (x13.7).

Protein differential expression in normal tissues from HIPED for NNMT Gene

This gene is overexpressed in Liver (15.2) and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NNMT Gene



SOURCE GeneReport for Unigene cluster for NNMT Gene Hs.503911

mRNA Expression by UniProt/SwissProt for NNMT Gene

P40261-NNMT_HUMAN
Tissue specificity: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.
genes like me logo Genes that share expression patterns with NNMT: view

Protein tissue co-expression partners for NNMT Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NNMT Gene

This gene was present in the common ancestor of animals.

Orthologs for NNMT Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NNMT 35
  • 85.98 (n)
  • 85.61 (a)
NNMT 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nnmt 35
  • 82.95 (n)
  • 85.5 (a)
Nnmt 16
Nnmt 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NNMT 35
  • 99.62 (n)
  • 99.62 (a)
NNMT 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nnmt 35
  • 83.91 (n)
  • 87.26 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia NNMT 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NNMT 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127789 35
  • 52.9 (n)
  • 46.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69005 35
zebrafish
(Danio rerio)
Actinopterygii zgc:64002 36
  • 39 (a)
ManyToMany
zgc:64002 36
  • 38 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea anmt-1 36
  • 23 (a)
ManyToMany
anmt-2 36
  • 23 (a)
ManyToMany
anmt-3 36
  • 22 (a)
ManyToMany
Species with no ortholog for NNMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NNMT Gene

ENSEMBL:
Gene Tree for NNMT (if available)
TreeFam:
Gene Tree for NNMT (if available)

Paralogs for NNMT Gene

Paralogs for NNMT Gene

(3) SIMAP similar genes for NNMT Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NNMT Gene

genes like me logo Genes that share paralogs with NNMT: view

Variants for NNMT Gene

Sequence variations from dbSNP and Humsavar for NNMT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs949372 -- 114,298,738(+) ATACT(C/T)ACAAC intron-variant
rs949374 -- 114,302,647(-) TATAC(G/T)TAACA intron-variant
rs1050207 -- 114,312,415(+) CTTCC(A/C)CCATG reference, missense
rs1802605 -- 114,296,622(+) CTAGA(A/G)AAATA reference, synonymous-codon
rs1802606 -- 114,296,662(+) AAAGC(A/C)AGATT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NNMT Gene

Variant ID Type Subtype PubMed ID
nsv898395 CNV Gain 21882294

Variation tolerance for NNMT Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NNMT Gene

HapMap Linkage Disequilibrium report
NNMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NNMT Gene

Disorders for NNMT Gene

MalaCards: The human disease database

(1) MalaCards diseases for NNMT Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • parkinson disease
- elite association - COSMIC cancer census association via MalaCards
Search NNMT in MalaCards View complete list of genes associated with diseases

Relevant External Links for NNMT

Genetic Association Database (GAD)
NNMT
Human Genome Epidemiology (HuGE) Navigator
NNMT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NNMT
genes like me logo Genes that share disorders with NNMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NNMT Gene

Publications for NNMT Gene

  1. Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. (PMID: 8575745) Aksoy S. … Weinshilboum R.M. (Genomics 1995) 2 3 4 23 67
  2. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. (PMID: 18996527) Riederer M. … Zechner R. (Atherosclerosis 2009) 3 23 25 26
  3. Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma. (PMID: 19924637) Emanuelli M. … Lo Muzio L. (Histol. Histopathol. 2010) 3 23
  4. Nicotinamide N-methyltransferase protein expression in renal cell cancer. (PMID: 20104648) Zhang J. … He C. (J Zhejiang Univ Sci B 2010) 3 23
  5. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. (PMID: 19020309) de Jonge R. … Pieters R. (Blood 2009) 3 23

Products for NNMT Gene

Sources for NNMT Gene

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