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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NNMT Gene

protein-coding   GIFtS: 64
GCID: GC11P114162

Nicotinamide N-Methyltransferase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nicotinamide N-Methyltransferase1 2
EC 2.1.1.13

External Ids:    HGNC: 78611   Entrez Gene: 48372   Ensembl: ENSG000001667417   OMIM: 6000085   UniProtKB: P402613   

Export aliases for NNMT gene to outside databases

Previous GC identifers: GC11P116520 GC11P115640 GC11P113666 GC11P113633 GC11P110095


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NNMT Gene:
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene
encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NNMT Gene: 
NNMT (nicotinamide N-methyltransferase) is a protein-coding gene. Diseases associated with NNMT include pellagra, and stomach cancer, and among its related super-pathways are Phase II conjugation and NAD metabolism. GO annotations related to this gene include nicotinamide N-methyltransferase activity. An important paralog of this gene is PNMT.

UniProtKB/Swiss-Prot: NNMT_HUMAN, P40261
Function: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity
is important for biotransformation of many drugs and xenobiotic compounds

Gene Wiki entry for NNMT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NNMT gene promoter:
         GATA-3   Brachyury   STAT6   HNF-3beta   GATA-1   GATA-2   FOXC1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NNMT promoter sequence
   Search SABiosciences Chromatin IP Primers for NNMT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NNMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23.1

NNMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NNMT gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P114162:  view genomic region     (about GC identifiers)

Start:
114,128,509 bp from pter      End:
114,184,007 bp from pter
Size:
55,499 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NNMT_HUMAN, P40261 (See protein sequence)
Recommended Name: Nicotinamide N-methyltransferase  
Size: 264 amino acids; 29574 Da
Subunit: Monomer
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for NNMT:
2IIP (3D)        3ROD (3D)    

Explore the universe of human proteins at neXtProt for NNMT: NX_P40261

Explore proteomics data for NNMT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40261

  • NNMT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NNMT Protein Expression
    REFSEQ proteins: NP_006160.1  
    ENSEMBL proteins: 
     ENSP00000441434   ENSP00000299964   ENSP00000445680   ENSP00000445994   ENSP00000445248  
    Reactome Protein details: P40261
    Human Recombinant Protein Products for NNMT: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NNMT (Nicotinamide N-Methyltransferase/NNMT)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NNMT
    OriGene Protein Over-expression Lysate for NNMT
    OriGene MassSpec for NNMT 
    OriGene Custom Protein Services for NNMT
    GenScript Custom Purified and Recombinant Proteins Services for NNMT
    Novus Biologicals NNMT Proteins
    Novus Biologicals NNMT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NNMT
    Cloud-Clone Corp. Proteins for NNMT 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    NNMT for ontologies           About GeneDecksing



    NNMT Antibody Products: 
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    Novus Biologicals NNMT Antibodies
    Abcam antibodies for NNMT
    Cloud-Clone Corp. Antibodies for NNMT 
    ThermoFisher Antibodies for NNMT
    LSBio Antibodies in human, mouse, rat for NNMT 

    Assay Products for NNMT: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NNMT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NNMT 
    Cloud-Clone Corp. CLIAs for NNMT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000940 NNMT_TEMT_trans
     IPR025818 NNMT
     IPR025820 NNMT/PNMT/TEMT_CS

    Graphical View of Domain Structure for InterPro Entry P40261

    ProtoNet protein and cluster: P40261

    1 Blocks protein domain: IPB000940 Methyltransferase

    UniProtKB/Swiss-Prot: NNMT_HUMAN, P40261
    Similarity: Belongs to the NNMT/PNMT/TEMT family


    NNMT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NNMT_HUMAN, P40261
    Function: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity
    is important for biotransformation of many drugs and xenobiotic compounds
    Catalytic activity: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide

         Genatlas biochemistry entry for NNMT:
    nicotinamide N-methyltransferase

         Enzyme Number (IUBMB): EC 2.1.1.11

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008112nicotinamide N-methyltransferase activity IEA--
    GO:0008168methyltransferase activity ----
         
    NNMT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NNMT:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NNMT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NNMT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NNMT 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NNMT 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NNMT
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NNMT
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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene ORF clones in mouse, rat for NNMT
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    GenScript: all cDNA clones in your preferred vector: NNMT (NM_006169)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NNMT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NNMT
    Sirion Biotech Customized lentivirus for stable overexpression of NNMT 
                         Customized lentivirus expression plasmids for stable overexpression of NNMT 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NNMT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NNMT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    2NAD metabolism
    NAD metabolism0.43
    Nicotinate and nicotinamide metabolism0.43
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4methionine degradation I (to homocysteine)
    Methylation0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NNMT
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for NNMT
        NAD metabolism

    1 BioSystems Pathway for NNMT
        metapathway biotransformation

    4        Reactome Pathways for NNMT
        Metabolism
    Biological oxidations
    Phase II conjugation
    Methylation


    2         Kegg Pathways  (Kegg details for NNMT):
        Nicotinate and nicotinamide metabolism
    Metabolic pathways


    NNMT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NNMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for NNMT (ENSP000002999644) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AHCYENSP000002174264STRING: ENSP00000217426
    AOX1ENSP000003638324STRING: ENSP00000363832
    CD38ENSP000002262794STRING: ENSP00000226279
    PNPENSP000003545324STRING: ENSP00000354532
    BST1ENSP000002650164STRING: ENSP00000265016
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0010243response to organonitrogen compound IEA--
    GO:0031100organ regeneration IEA--
    GO:0032259methylation TAS--
    GO:0042493response to drug IEA--

    NNMT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NNMT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NNMT

    4 HMDB Compounds for NNMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylnicotinamide1-Methyl-3-carbamoylpyridinium (see all 13)3106-60-3--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    1 DrugBank Compound for NNMT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Niacin3-Pyridinecarboxylic acid (see all 9)59-67-6targetbinder17139284 18996527 17016423

    10 Novoseek inferred chemical compound relationships for NNMT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nnmt 99.7 349 20110558 (12), 17922140 (11), 19242722 (10), 8845860 (10) (see all 49)
    nicotinamide 93.1 151 17070307 (8), 20495288 (8), 14557485 (3), 11853016 (2) (see all 45)
    n(1)-methylnicotinamide 87.3 14 20495288 (3), 18996527 (2), 9464457 (1), 15294753 (1) (see all 6)
    4-phenylpyridine 85 2 15728403 (1), 15639403 (1)
    mptp 44.4 1 15922112 (1)
    homocysteine 41.5 10 18996527 (3), 15849667 (2), 17412799 (1), 18441319 (1) (see all 5)
    s-adenosylmethionine 39.3 5 15728403 (1), 8182091 (1), 8845860 (1)
    nad+ 36.1 9 20495288 (3), 12727306 (1)
    pyridine 27.9 3 2311261 (2)
    dopamine 0 2 11188501 (2)

    Search CenterWatch for drugs/clinical trials and news about NNMT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NNMT gene: 
    NM_006169.2  

    Unigene Cluster for NNMT:

    Nicotinamide N-methyltransferase
    Hs.503911  [show with all ESTs]
    Unigene Representative Sequence: NM_006169
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535185 ENST00000535401(uc001por.1) ENST00000541090 ENST00000299964(uc001pos.1)
    ENST00000546313 ENST00000541754 ENST00000542647 ENST00000545255

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NNMT
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NNMT
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NNMT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NNMT
    Clone
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    OriGene clones in human, mouse for NNMT (see all 6)
    OriGene ORF clones in mouse, rat for NNMT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NNMT (NM_006169)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NNMT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NNMT
    Sirion Biotech Customized lentivirus for stable overexpression of NNMT 
                         Customized lentivirus expression plasmids for stable overexpression of NNMT 
    Primer
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    OriGene qPCR primer pairs and template standards for NNMT
    OriGene qSTAR qPCR primer pairs in human, mouse for NNMT
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NNMT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NNMT

    Additional mRNA sequence: 

    AK026845.1 BC000234.1 CR541907.1 U08021.1 

    17 DOTS entries:

    DT.100888427  DT.95133415  DT.40210692  DT.99939633  DT.95133400  DT.95133402  DT.120690892  DT.120690906 
    DT.95112241  DT.120690884  DT.92447632  DT.97854667  DT.120690896  DT.100888421  DT.100888422  DT.100888423 
    DT.120690918 

    24/575 AceView cDNA sequences (see all 575):

    CA421133 BM672702 BG569593 CA412485 CB138540 CB147431 BU687410 AA297585 
    BU732266 BM773452 CR600284 BQ573851 CB122097 BF435228 BQ008691 BF343537 
    CB162461 CB115562 BU628813 CR612730 BQ573835 BQ773332 BQ674689 CA412569 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NNMT expression in normal human tissues (normalized intensities)      NNMT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAACAACG
    NNMT Expression
    About this image


    NNMT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Fibroblast
             Detroit 551
             Human Prostate Fibroblasts (HPrF)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Wharton's jelly-derived stem cells
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Human Skeletal Muscle Satellite Cells (HSkMSC)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Trigeminal Ganglion   

    See NNMT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NNMT

    SOURCE GeneReport for Unigene cluster: Hs.503911

    UniProtKB/Swiss-Prot: NNMT_HUMAN, P40261
    Tissue specificity: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal
    muscle, placenta and heart. Not detected in the brain or pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including NNMT: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NNMT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NNMT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NNMT gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nnmt1 , 5 nicotinamide N-methyltransferase1, 5 82.95(n)1
    85.5(a)1
      9 (26.45 cM)5
    181131  NM_010924.21  NP_035054.11 
     485918775 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    52(a)
    52(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    GL343521.1(402825-410630)
    GL343722.1(158417-161010)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690052 hypothetical protein MGC69005 68.9(n)    BC056046.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:640021 zgc:64002 49.93(n)
    40(a)
      393330  NM_001111246.2  NP_001104716.2 
    worm
    (Caenorhabditis elegans)
    Secernentea anmt-16
    anmt-36
    (see all 3)
    Protein T07C12.9
    (see all 3)
    23(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(8684808-8686481)
    V(9956880-9958331)


    ENSEMBL Gene Tree for NNMT (if available)
    TreeFam Gene Tree for NNMT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NNMT gene
    PNMT2  INMT2  INMT-FAM188B2  
    3 SIMAP similar genes for NNMT using alignment to 3 protein entries:     NNMT_HUMAN (see all proteins):
    INMT-FAM188B    INMT    PNMT

    NNMT for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NNMT
    PGOHUM00000242900 PGOHUM00000232637


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/408 SNPs in NNMT are shown (see all 408)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1167133701,2
    C,F--114164612(+) AAGTGT/ACCATT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs2015896691,2
    C--114164752(+) AACCA-/GGCACA 1 -- us2k10--------
    rs1420009881,2
    --114164869(+) GGTAGC/TGAGGT 1 -- us2k10--------
    rs1807408271,2
    --114164942(+) GCTCAC/TGCCTG 1 -- us2k10--------
    rs28524311,2
    C,H--114164976(-) ccgccC/Tacctc 1 -- us2k19Minor allele frequency- T:0.06NA WA CSA 17
    rs1392418951,2
    --114165029(+) ACCCCA/GTCTCT 1 -- us2k10--------
    rs1864665521,2
    C--114165066(+) GTGATA/GGTGTG 1 -- us2k10--------
    rs783440301,2
    C--114165155(+) AGATCA/GCGTCA 1 -- us2k10--------
    rs112149361,2
    C,F,A,H--114165225(+) agaaaG/Tattga 1 -- us2k18Minor allele frequency- T:0.30NS EA NA 510
    rs24449881,2
    C,F,H--114165349(-) TCAAGC/TACTTA 1 -- us2k115Minor allele frequency- T:0.05NS EA WA NA CSA 792

    HapMap Linkage Disequilibrium report for NNMT (114128509 - 114184007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NNMT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898395CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600008    OMIM disorders: --

    20/30 diseases for NNMT (see all 30):    About MalaCards
    pellagra    stomach cancer    patent ductus arteriosus    thyroid cancer
    congenital heart defect    oral squamous cell carcinoma    abdominal aortic aneurysm    spina bifida
    neurologic diseases    renal clear cell carcinoma    papillary thyroid carcinoma    aortic aneurysm
    parkinson's disease    chronic obstructive pulmonary disease    migraine    insulinoma
    acute lymphoblastic leukemia    gastric cancer    thyroiditis    colorectal cancer


    NNMT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for NNMT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    papillary thyroid cancer 49.8 6 16676400 (3), 15486044 (2)
    parkinson disease 41.6 7 12727306 (2), 11853016 (1), 11154840 (1), 11188501 (1)
    thyroid cancer 22.7 1 15486044 (1)
    carcinoma renal cell 20.8 9 20104648 (3), 17070307 (2)
    colorectal cancer 16.6 7 16166432 (5), 16893879 (1)
    tumors 10.9 32 17070307 (5), 19216803 (4), 20495288 (3), 16166432 (2) (see all 10)
    cancer 10.2 10 17922140 (3), 18724390 (2), 17079861 (1), 14557485 (1) (see all 5)
    gastric cancer 2.39 3 17079861 (2), 15559763 (1)

    Genetic Association Database (GAD): NNMT
    Human Genome Epidemiology (HuGE) Navigator: NNMT (15 documents)

    Export disorders for NNMT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NNMT gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with NNMT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. (PubMed id 8575745)1, 2, 3, 9 Aksoy S.... Weinshilboum R.M. (1995)
    2. Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. (PubMed id 8182091)1, 2, 9 Aksoy S.... Weinshilboum R.M. (1994)
    3. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. (PubMed id 18996527)1, 7, 9 Riederer M....Zechner R. (2009)
    4. Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida. (PubMed id 18553462)1, 4, 9 Lu W....Finnell R.H. (2008)
    5. Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide. (PubMed id 18441319)1, 4, 9 van Driel L.M....Steegers-Theunissen R.P. (2008)
    6. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (PubMed id 18635682)1, 4, 9 Giusti B....Abbate R. (2008)
    7. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. (PubMed id 19020309)1, 4, 9 de Jonge R....Pieters R. (2008)
    8. High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism. (PubMed id 18427977)1, 4, 9 Giusti B....Abbate R. (2008)
    9. Genetic and environmental influences on plasma homocysteine: results from a Danish twin study. (PubMed id 17412799)1, 4, 9 Bathum L....Kyvik K.O. (2007)
    10. The relationship between homocysteine and genes of fo late-related enzymes in migraine patients. (PubMed id 19619240)1, 4 Oterino A....Pascual J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4837 HGNC: 7861 AceView: NNMT Ensembl:ENSG00000166741 euGenes: HUgn4837
    ECgene: NNMT Kegg: 4837 H-InvDB: NNMT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NNMT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NNMT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NNMT gene:
    Search GeneIP for patents involving NNMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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