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Aliases for NNMT Gene

Aliases for NNMT Gene

  • Nicotinamide N-Methyltransferase 2 3 5
  • EC 2.1.1.1 4

External Ids for NNMT Gene

Previous GeneCards Identifiers for NNMT Gene

  • GC11P116520
  • GC11P115640
  • GC11P114162
  • GC11P113666
  • GC11P113633
  • GC11P110095

Summaries for NNMT Gene

Entrez Gene Summary for NNMT Gene

  • N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]

GeneCards Summary for NNMT Gene

NNMT (Nicotinamide N-Methyltransferase) is a Protein Coding gene. Diseases associated with NNMT include Kidney Cancer and Parkinson Disease, Late-Onset. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. GO annotations related to this gene include methyltransferase activity and nicotinamide N-methyltransferase activity. An important paralog of this gene is INMT.

UniProtKB/Swiss-Prot for NNMT Gene

  • Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

Gene Wiki entry for NNMT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NNMT Gene

Genomics for NNMT Gene

Regulatory Elements for NNMT Gene

Enhancers for NNMT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F114152 2.8 FANTOM5 Ensembl ENCODE 11.5 -87.3 -87265 35.9 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 FOS ZNF263 SP5 LRRC37A13P RBM7 ZW10 NXPE2P1 ZBTB16 NNMT LOC101928940 ENSG00000270179 REXO2 HTR3A
GH11F114288 1.1 ENCODE 20.4 +37.7 37668 13.1 PKNOX1 ARNT FEZF1 ZNF2 YY1 FOS ZNF263 SP3 SP5 REST RBM7 ZW10 LOC101928940 NNMT REXO2 ENSG00000270179 C11orf71 ENSG00000255663 NXPE1 GC11P114306
GH11F114214 1.6 FANTOM5 Ensembl ENCODE 11.8 -41.2 -41162 3.6 PKNOX1 ATF1 ARNT CBX5 GATA2 GTF2B NCOA1 REST SMARCB1 MBD2 NNMT RBM7 ZBTB16 PIR38575 PIR57549
GH11F114057 1.5 FANTOM5 Ensembl ENCODE 10.4 -194.5 -194501 11.2 ZNF76 KLF17 GLI4 RAD21 YY1 GLIS2 ZNF366 SCRT2 EGR2 ZNF263 NNMT ZBTB16 GC11M114060 LOC101928875
GH11F114035 1.3 Ensembl ENCODE 11.6 -221.5 -221460 1.3 PKNOX1 FEZF1 ZNF48 ZNF2 GLIS2 ZNF143 TSHZ1 REST SSRP1 SMARCA4 NNMT RNU6-1107P GC11P114027 GC11P114056
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NNMT on UCSC Golden Path with GeneCards custom track

Genomic Location for NNMT Gene

Chromosome:
11
Start:
114,257,787 bp from pter
End:
114,313,285 bp from pter
Size:
55,499 bases
Orientation:
Plus strand

Genomic View for NNMT Gene

Genes around NNMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NNMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NNMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NNMT Gene

Proteins for NNMT Gene

  • Protein details for NNMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40261-NNMT_HUMAN
    Recommended name:
    Nicotinamide N-methyltransferase
    Protein Accession:
    P40261

    Protein attributes for NNMT Gene

    Size:
    264 amino acids
    Molecular mass:
    29574 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NNMT Gene

neXtProt entry for NNMT Gene

Post-translational modifications for NNMT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NNMT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NNMT (Nicotinamide N-Methyltransferase/NNMT)
  • Abcam antibodies for NNMT

No data available for DME Specific Peptides for NNMT Gene

Domains & Families for NNMT Gene

Suggested Antigen Peptide Sequences for NNMT Gene

Graphical View of Domain Structure for InterPro Entry

P40261

UniProtKB/Swiss-Prot:

NNMT_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
genes like me logo Genes that share domains with NNMT: view

No data available for Gene Families for NNMT Gene

Function for NNMT Gene

Molecular function for NNMT Gene

GENATLAS Biochemistry:
nicotinamide N-methyltransferase
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
UniProtKB/Swiss-Prot Function:
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

Enzyme Numbers (IUBMB) for NNMT Gene

Gene Ontology (GO) - Molecular Function for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IPI --
GO:0003674 molecular_function ND --
GO:0005521 lamin binding IDA --
GO:0008112 nicotinamide N-methyltransferase activity IEA,TAS --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with NNMT: view
genes like me logo Genes that share phenotypes with NNMT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NNMT

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NNMT

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NNMT Gene

Localization for NNMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NNMT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NNMT gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NNMT: view

Pathways & Interactions for NNMT Gene

genes like me logo Genes that share pathways with NNMT: view

Pathways by source for NNMT Gene

Interacting Proteins for NNMT Gene

Gene Ontology (GO) - Biological Process for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA --
GO:0010243 response to organonitrogen compound IEA --
GO:0031100 animal organ regeneration IEA --
GO:0032259 methylation TAS --
genes like me logo Genes that share ontologies with NNMT: view

No data available for SIGNOR curated interactions for NNMT Gene

Drugs & Compounds for NNMT Gene

(6) Drugs for NNMT Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist, Target, binder 906,906
Nicotinamide Approved Nutra 902,906
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
ARI-3037MO Pharma inhibitor, agonist 0

(9) Additional Compounds for NNMT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Methylnicotinamide
  • 1-Methyl-3-carbamoylpyridinium
  • 1-Methyl-3-carbamoylpyridinium cation
  • 1-Methylnicotinamide
  • 3-Amido-N-methylpyridinium: 1-methyl-3-Pyridinecarboxamide
  • 3-Carbamoyl-1-methyl-Pyridinium
3106-60-3
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with NNMT: view

Transcripts for NNMT Gene

Unigene Clusters for NNMT Gene

Nicotinamide N-methyltransferase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NNMT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NNMT Gene

No ASD Table

Relevant External Links for NNMT Gene

GeneLoc Exon Structure for
NNMT
ECgene alternative splicing isoforms for
NNMT

Expression for NNMT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NNMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NNMT Gene

This gene is overexpressed in Liver (x13.7).

Protein differential expression in normal tissues from HIPED for NNMT Gene

This gene is overexpressed in Liver (15.2) and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NNMT Gene



Protein tissue co-expression partners for NNMT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NNMT Gene:

NNMT

SOURCE GeneReport for Unigene cluster for NNMT Gene:

Hs.503911

mRNA Expression by UniProt/SwissProt for NNMT Gene:

P40261-NNMT_HUMAN
Tissue specificity: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.
genes like me logo Genes that share expression patterns with NNMT: view

Primer Products

Orthologs for NNMT Gene

This gene was present in the common ancestor of animals.

Orthologs for NNMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NNMT 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia NNMT 34 35
  • 85.98 (n)
rat
(Rattus norvegicus)
Mammalia Nnmt 34
  • 83.91 (n)
mouse
(Mus musculus)
Mammalia Nnmt 34 16 35
  • 82.95 (n)
oppossum
(Monodelphis domestica)
Mammalia NNMT 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NNMT 35
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127789 34
  • 52.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69005 34
zebrafish
(Danio rerio)
Actinopterygii zgc:64002 35 35
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea anmt-1 35
  • 23 (a)
ManyToMany
anmt-2 35
  • 23 (a)
ManyToMany
anmt-3 35
  • 22 (a)
ManyToMany
Species where no ortholog for NNMT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NNMT Gene

ENSEMBL:
Gene Tree for NNMT (if available)
TreeFam:
Gene Tree for NNMT (if available)

Paralogs for NNMT Gene

Paralogs for NNMT Gene

(3) SIMAP similar genes for NNMT Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NNMT Gene

genes like me logo Genes that share paralogs with NNMT: view

Variants for NNMT Gene

Sequence variations from dbSNP and Humsavar for NNMT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1050207 -- 114,312,415(+) CTTCC(A/C)CCATG reference, missense
rs10891645 -- 114,300,525(+) AATAT(A/C)AATTA intron-variant
rs111775424 -- 114,296,615(+) GGATT(A/G)CCTAG reference, missense
rs111859645 -- 114,307,134(+) TCTCC(C/T)CAGGA intron-variant
rs111985590 -- 114,298,706(+) TATTA(A/T)TCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NNMT Gene

Variant ID Type Subtype PubMed ID
esv3360369 CNV duplication 20981092

Variation tolerance for NNMT Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NNMT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NNMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NNMT Gene

Disorders for NNMT Gene

MalaCards: The human disease database

(2) MalaCards diseases for NNMT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kidney cancer
  • malignant neoplasm of kidney except pelvis
parkinson disease, late-onset
  • parkinson disease
- elite association - COSMIC cancer census association via MalaCards
Search NNMT in MalaCards View complete list of genes associated with diseases

Relevant External Links for NNMT

Genetic Association Database (GAD)
NNMT
Human Genome Epidemiology (HuGE) Navigator
NNMT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NNMT
genes like me logo Genes that share disorders with NNMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NNMT Gene

Publications for NNMT Gene

  1. Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. (PMID: 8575745) Aksoy S. … Weinshilboum R.M. (Genomics 1995) 2 3 4 22 64
  2. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. (PMID: 18996527) Riederer M. … Zechner R. (Atherosclerosis 2009) 3 22 25 64
  3. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. (PMID: 19020309) de Jonge R. … Pieters R. (Blood 2009) 3 22 46 64
  4. High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism. (PMID: 18427977) Giusti B. … Abbate R. (Biochem. Genet. 2008) 3 22 46 64
  5. Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide. (PMID: 18441319) van Driel L.M. … Steegers-Theunissen R.P. (Eur. Heart J. 2008) 3 22 46 64

Products for NNMT Gene

  • Cloud-Clone Corp. Antibodies for NNMT
  • Cloud-Clone Corp. Proteins for NNMT
  • Cloud-Clone Corp Assay Kits for NNMT

Sources for NNMT Gene

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