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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NNMT Gene

protein-coding GIFtS: 63
GCID: GC11P114162

nicotinamide N-methyltransferase

Explore 37 diseases affiliated with
NNMT via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nicotinamide N-Methyltransferase¹ ²
EC 2.1.1.1³

External Ids:	HGNC: 7861¹	Entrez Gene: 4837²	Ensembl: ENSG00000166741⁷	OMIM: 600008⁵	UniProtKB: P40261³

Export aliases for NNMT gene to outside databases

Previous GC identifers: GC11P116520 GC11P115640 GC11P113666 GC11P113633 GC11P110095

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NNMT:

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene

encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NNMT_HUMAN, P40261

Function: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is

important for biotransformation of many drugs and xenobiotic compounds

Gene Wiki entry for NNMT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NNMT gene promoter:
GATA-3 Brachyury STAT6 HNF-3beta GATA-1 GATA-2 FOXC1 SEF-1 (1)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NNMT promoter sequence

Search SABiosciences Chromatin IP Primers for NNMT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NNMT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q23.1

NNMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NNMT gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P114162: view genomic region (about GC identifiers)

Start:	114,128,509 bp from pter	End:	114,184,007 bp from pter
Size:	55,499 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NNMT_HUMAN, P40261 (See protein sequence)

Recommended Name: Nicotinamide N-methyltransferase

Size: 264 amino acids; 29574 Da

Subunit: Monomer

Subcellular location: Cytoplasm

2 PDB 3D structures from and Proteopedia for NNMT:

2IIP (3D)

3ROD (3D)

Explore the universe of human proteins at neXtProt for NNMT: NX_P40261

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P40261

NNMT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006160.1

ENSEMBL proteins:

ENSP00000441434 ENSP00000299964 ENSP00000445680 ENSP00000445994 ENSP00000445248

Reactome Protein details: P40261
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for NNMT (Nicotinamide N-Methyltransferase/NNMT)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NNMT OriGene Protein Over-expression Lysate: NNMT OriGene Custom Protein Services for NNMT
	GenScript Custom Purified and Recombinant Proteins Services for NNMT
	Novus Biologicals NNMT Proteins Novus Biologicals NNMT Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for NNMT
	Uscn Proteins for NNMT

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005829	cytosol	TAS	--

NNMT for ontologies About GeneDecksing

NNMT Antibody Products:

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	Search for Antibodies for NNMT at Abcam
	Uscn Antibodies for NNMT
	ThermoFisher Antibodies for NNMT

Assay Products for NNMT:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for NNMT
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NNMT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NNMT for domains About GeneDecksing

3 InterPro domains/families:

IPR000940 NNMT_TEMT_trans

IPR025818 NNMT

IPR025820 NNMT/PNMT/TEMT_CS

Graphical View of Domain Structure for InterPro Entry P40261

ProtoNet protein and cluster: P40261

1 Blocks protein family: IPB000940 Methyltransferase

UniProtKB/Swiss-Prot: NNMT_HUMAN, P40261

Similarity: Belongs to the NNMT/PNMT/TEMT family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NNMT_HUMAN, P40261

Function: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is

important for biotransformation of many drugs and xenobiotic compounds

Catalytic activity: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide

Genatlas biochemistry entry for NNMT:

nicotinamide N-methyltransferase

Enzyme Number (IUBMB): EC 2.1.1.1¹

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NNMT
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NNMT
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NNMT (see all 7) OriGene shRNA RFP: NNMT OriGene siRNA: NNMT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NNMT

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NNMT

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NNMT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NNMT OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NNMT (NM_006169)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NNMT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NNMT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NNMT
		Search LifeMap BioReagents cell lines for NNMT

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NNMT

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008112	nicotinamide N-methyltransferase activity	IEA	--
GO:0008168	methyltransferase activity	--	--

NNMT for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NNMT:

Increased number of cells in m

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

NAD metabolism

	NAD metabolism	1.00			Nicotinate and nicotinamide metabolism	0.43
	NAD metabolism	1.00

Biological oxidations

	Biological oxidations	1.00			metapathway biotransformation	0.41
	Phase II conjugation	0.52

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Methionine metabolism

Methylation

0.19

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NNMT

NAD metabolism

1 GeneGo (Thomson Reuters) Pathway for NNMT

NAD metabolism

1 BioSystems Pathway for NNMT

metapathway biotransformation

4 Reactome Pathways for NNMT

	Metabolism
	Biological oxidations
	Phase II conjugation
	Methylation

2 Kegg Pathways (Kegg details for NNMT):

	Nicotinate and nicotinamide metabolism
	Metabolic pathways

NNMT for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NNMT

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/9 Interacting proteins for NNMT (ENSP00000299964⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AHCY	ENSP00000217426⁴	STRING: ENSP00000217426
AOX1	ENSP00000363832⁴	STRING: ENSP00000363832
CD38	ENSP00000226279⁴	STRING: ENSP00000226279
PNP	ENSP00000354532⁴	STRING: ENSP00000354532
BST1	ENSP00000265016⁴	STRING: ENSP00000265016

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0010243	response to organic nitrogen	IEA	--
GO:0031100	organ regeneration	IEA	--
GO:0032259	methylation	TAS	--
GO:0042493	response to drug	IEA	--

NNMT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NNMT for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NNMT

4 HMDB Compounds for NNMT About this table

Compound	Synonyms	CAS #	PubMed Ids
1-Methylnicotinamide	1-Methyl-3-carbamoylpyridinium (see all 13)	3106-60-3	--
Niacinamide	3-Carbamoylpyridine (see all 77)	98-92-0	--
S-Adenosylhomocysteine	(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)	979-92-0	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

1 DrugBank Compound for NNMT About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Niacin	3-Pyridinecarboxylic acid (see all 9)	59-67-6	target	binder	17139284 18996527 17016423

10 Novoseek chemical compound relationships for NNMT gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nnmt	99.7	349	20110558 (12), 17922140 (11), 19242722 (10), 8845860 (10) (see all 49)
nicotinamide	93.1	151	17070307 (8), 20495288 (8), 14557485 (3), 11853016 (2) (see all 45)
n(1)-methylnicotinamide	87.3	14	20495288 (3), 18996527 (2), 9464457 (1), 15294753 (1) (see all 6)
4-phenylpyridine	85	2	15728403 (1), 15639403 (1)
mptp	44.4	1	15922112 (1)
homocysteine	41.5	10	18996527 (3), 15849667 (2), 17412799 (1), 18441319 (1) (see all 5)
s-adenosylmethionine	39.3	5	15728403 (1), 8182091 (1), 8845860 (1)
nad+	36.1	9	20495288 (3), 12727306 (1)
pyridine	27.9	3	2311261 (2)
dopamine	0	2	11188501 (2)

Search CenterWatch for drugs/clinical trials and news about NNMT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NNMT gene:

NM_006169.2

Unigene Cluster for NNMT:

Nicotinamide N-methyltransferase

Hs.503911 [show with all ESTs]

Unigene Representative Sequence: NM_006169

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000535185 ENST00000535401(uc001por.1) ENST00000541090 ENST00000299964(uc001pos.1)

ENST00000546313 ENST00000541754 ENST00000542647 ENST00000545255

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NNMT
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NNMT
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NNMT (see all 7) OriGene shRNA RFP: NNMT OriGene siRNA: NNMT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NNMT

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NNMT (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NNMT OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NNMT (NM_006169)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NNMT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NNMT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NNMT Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NNMT
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NNMT

Additional cDNA sequence:

AK026845.1 BC000234.1 CR541907.1 U08021.1

17 DOTS entries:

DT.100888427 DT.95133415 DT.40210692 DT.99939633 DT.95133400 DT.95133402 DT.120690892 DT.120690906

DT.95112241 DT.120690884 DT.92447632 DT.97854667 DT.120690896 DT.100888421 DT.100888422 DT.100888423

DT.120690918

24/575 AceView cDNA sequences (see all 575):

CB162377 CB147400 CB268783 AW068219 CA413955 BQ947981 CB157576 BG750373

BQ717720 BQ955663 CB135231 BQ573912 BQ670771 BQ229884 BQ009723 BQ268400

CB122140 BX403733 CB121401 CB144243 AA401162 CB135651 BU615339 CB145804

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NNMT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAACAACG

About this image

NNMT expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Mature Sertoli Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

CD31, CD144 positive cells (Two-step protocol fo...)

See NNMT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NNMT

SOURCE GeneReport for Unigene cluster: Hs.503911

UniProtKB/Swiss-Prot: NNMT_HUMAN, P40261

Tissue specificity: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal

muscle, placenta and heart. Not detected in the brain or pancreas

SABiosciences Expression via Pathway-Focused PCR Array including NNMT:

Drug Metabolism: Phase II Enzymes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NNMT Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NNMT

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NNMT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NNMT gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	52(a)	1 ↔ 1	GL343722.1(227490-232981)
African clawed frog (Xenopus laevis)	Amphibia	MGC69005²	hypothetical protein MGC69005	68.9(n)		BC056046.1
zebrafish (Danio rerio)	Actinopterygii	zgc:64002¹	zgc:64002	49.93(n) 40(a)		393330 NM_001111246.2 NP_001104716.2
worm (Caenorhabditis elegans)	Secernentea	F42A10.3⁶ B0303.2⁶ (see all 3)	Uncharacterized methyltransferase B0303.2 (see all 3)	24(a) 24(a) (see all 3)	many ↔ many many ↔ many (see all 3)	III(6154662-6157706) III(8684727-8686400)

ENSEMBL Gene Tree for NNMT (if available)
TreeFam Gene Tree for NNMT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NNMT gene

PNMT² INMT² INMT-FAM188B²

3 SIMAP similar genes for NNMT using alignment to 3 protein entries: NNMT_HUMAN (see all proteins):

INMT-FAM188B INMT PNMT

NNMT for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for NNMT
PGOHUM00000242900 PGOHUM00000232637

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116713370^1,2		--	114164612(+)	`AAGTGT/ACCATT`	1	--	us2k¹		1		WA	118
rs201589669^1,2		--	114164752(+)	`AACCA-/GGCACA`	1	--	us2k¹		0	--	--	--	--
rs142000988^1,2		--	114164869(+)	`GGTAGC/TGAGGT`	1	--	us2k¹		0	--	--	--	--
rs180740827^1,2		--	114164942(+)	`GCTCAC/TGCCTG`	1	--	us2k¹		0	--	--	--	--
rs2852431^1,2	C,H,	--	114164976(-)	`CCGCCC/TACCTC`	1	--	us2k¹		9		NA WA CSA	17
rs139241895^1,2		--	114165029(+)	`ACCCCA/GTCTCT`	1	--	us2k¹		0	--	--	--	--
rs186466552^1,2		--	114165066(+)	`GTGATA/GGTGTG`	1	--	us2k¹		0	--	--	--	--
rs78344030^1,2	C	--	114165155(+)	`AGATCA/GCGTCA`	1	--	us2k¹		0	--	--	--	--
rs11214936^1,2	C,F,A,H,	--	114165225(+)	`AGAAAG/TATTGA`	1	--	us2k¹		8		NS EA NA	510
rs2444988^1,2	C,F,H,	--	114165349(-)	`TCAAGC/TACTTA`	1	--	us2k¹		15		NS EA WA NA CSA	792

HapMap Linkage Disequilibrium report for NNMT (114128509 - 114184007 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NNMT: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NNMT

DNA2.0 Custom Variant and Variant Library Synthesis for NNMT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NNMT for disorders           About GeneDecksing

OMIM gene information: 600008    OMIM disorders: --

20/37 diseases for NNMT (see all 37):    About MalaCards

homocysteine plasma level patent ductus arteriosus abdominal aortic aneurysm aortic aneurysm

spina bifida congenital heart defect renal clear cell carcinoma chronic obstructive pulmonary disease

oral squamous cell carcinoma pellagra squamous cell carcinoma papillary thyroid carcinoma

acute lymphoblastic leukemia lymphoblastic leukemia parkinson's disease thyroid cancer

pulmonary disease thyroiditis stomach cancer homocysteine

1 disease from the University of Copenhagen DISEASES database for NNMT:

Pellagra

8 Novoseek disease relationships for NNMT gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
papillary thyroid cancer	49.8	6	16676400 (3), 15486044 (2)
parkinson disease	41.6	7	12727306 (2), 11853016 (1), 11154840 (1), 11188501 (1)
thyroid cancer	22.7	1	15486044 (1)
carcinoma renal cell	20.8	9	20104648 (3), 17070307 (2)
colorectal cancer	16.6	7	16166432 (5), 16893879 (1)
tumors	10.9	32	17070307 (5), 19216803 (4), 20495288 (3), 16166432 (2) (see all 10)
cancer	10.2	10	17922140 (3), 18724390 (2), 17079861 (1), 14557485 (1) (see all 5)
gastric cancer	2.39	3	17079861 (2), 15559763 (1)

Human Genome Epidemiology (HuGE) Navigator: NNMT (15 documents)

Export disorders for NNMT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NNMT gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with NNMT)

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Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. (PubMed id 8575745)^{1, 2, 3, 9} Aksoy S.... Weinshilboum R.M. (1995)
Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. (PubMed id 8182091)^{1, 2, 9} Aksoy S.... Weinshilboum R.M. (1994)
Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. (PubMed id 18996527)^{1, 7, 9} Riederer M....Zechner R. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human ERp29: isolation, primary structural characterisation and two- dimensional gel mapping. (PubMed id 11271497)^{1, 2} Hubbard M.J. and McHugh N.J. (2000)
Serum levels of nicotinamide N-methyltransferase in p atients with lung cancer. (PubMed id 19242722)^{1, 9} Tomida M....Akiyama H. (2009)
Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells. (PubMed id 17922140)^{1, 9} Tomida M....Kurosumi M. (2008)
Human nicotinamide N-methyltransferase pharmacogenetics: gene sequence analysis and promoter characterization. (PubMed id 10471062)^{1, 9} Yan L....Weinshilboum R.M. (1999)
Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains. (PubMed id 8845860)^{1, 9} Scheller T....Weinshilboum R.M. (1996)
Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis. (PubMed id 19216803)^{1, 9} Kim J....Kim D.S. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4837	HGNC: 7861	AceView: NNMT	Ensembl:ENSG00000166741	euGenes: HUgn4837
ECgene: NNMT	Kegg: 4837	H-InvDB: NNMT

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NNMT	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NNMT gene
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Patent Information for NNMT gene:
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