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Aliases for NNAT Gene

Aliases for NNAT Gene

  • Neuronatin 2 3
  • Peg5 3

External Ids for NNAT Gene

Previous GeneCards Identifiers for NNAT Gene

  • GC20P035878
  • GC20P035838
  • GC20P036788
  • GC20P036835
  • GC20P035583
  • GC20P036149
  • GC20P032885

Summaries for NNAT Gene

Entrez Gene Summary for NNAT Gene

  • The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of the BLCAP gene, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

GeneCards Summary for NNAT Gene

NNAT (Neuronatin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NNAT Gene

  • May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NNAT Gene

Genomics for NNAT Gene

Regulatory Elements for NNAT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NNAT Gene

Start:
37,521,205 bp from pter
End:
37,523,693 bp from pter
Size:
2,489 bases
Orientation:
Plus strand

Genomic View for NNAT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NNAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NNAT Gene

Proteins for NNAT Gene

  • Protein details for NNAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16517-NNAT_HUMAN
    Recommended name:
    Neuronatin
    Protein Accession:
    Q16517
    Secondary Accessions:
    • B2R558
    • E1P5V6
    • Q16596
    • Q5U0N3

    Protein attributes for NNAT Gene

    Size:
    81 amino acids
    Molecular mass:
    9237 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NNAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NNAT Gene

Proteomics data for NNAT Gene at MOPED

Post-translational modifications for NNAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NNAT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NNAT Gene

Domains for NNAT Gene

Protein Domains for NNAT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NNAT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16517

UniProtKB/Swiss-Prot:

NNAT_HUMAN :
  • Q16517
Family:
  • Belongs to the neuronatin family.
genes like me logo Genes that share domains with NNAT: view

No data available for Gene Families for NNAT Gene

Function for NNAT Gene

Molecular function for NNAT Gene

UniProtKB/Swiss-Prot Function:
May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels

Phenotypes for NNAT Gene

MGI mutant phenotypes for NNAT:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NNAT: view

Animal Models for NNAT Gene

MGI Knock Outs for NNAT:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NNAT

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for NNAT Gene

Localization for NNAT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NNAT Gene COMPARTMENTS Subcellular localization image for NNAT gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NNAT Gene

Pathways for NNAT Gene

SuperPathways for NNAT Gene

No Data Available

Interacting Proteins for NNAT Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000062104%0d%0a9606.ENSP00000345464%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000062104 for NNAT Gene via STRING

Gene Ontology (GO) - Biological Process for NNAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8813377
GO:0007420 brain development IEA --
GO:0009249 protein lipoylation TAS 8813377
GO:0030182 neuron differentiation IEA --
genes like me logo Genes that share ontologies with NNAT: view

No data available for Pathways by source for NNAT Gene

Transcripts for NNAT Gene

mRNA/cDNA for NNAT Gene

Unigene Clusters for NNAT Gene

Neuronatin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NNAT

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NNAT Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - -
SP3: -

Relevant External Links for NNAT Gene

GeneLoc Exon Structure for
NNAT
ECgene alternative splicing isoforms for
NNAT

Expression for NNAT Gene

mRNA expression in normal human tissues for NNAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NNAT Gene

This gene is overexpressed in Pituitary (16.5), Brain - Nucleus accumbens (basal ganglia) (8.4), Brain - Caudate (basal ganglia) (4.8), and Brain - Putamen (basal ganglia) (4.6).

SOURCE GeneReport for Unigene cluster for NNAT Gene Hs.504703

genes like me logo Genes that share expressions with NNAT: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for NNAT Gene

Orthologs for NNAT Gene

This gene was present in the common ancestor of mammals.

Orthologs for NNAT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NNAT 35
  • 94.65 (n)
  • 98.77 (a)
NNAT 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC609195 35
  • 96.71 (n)
  • 100 (a)
NNAT 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nnat 35
  • 96.71 (n)
  • 98.77 (a)
Nnat 16
Nnat 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NNAT 35
  • 100 (n)
  • 100 (a)
NNAT 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nnat 35
  • 96.3 (n)
  • 97.53 (a)
Species with no ortholog for NNAT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NNAT Gene

ENSEMBL:
Gene Tree for NNAT (if available)
TreeFam:
Gene Tree for NNAT (if available)

Paralogs for NNAT Gene

No data available for Paralogs for NNAT Gene

Variants for NNAT Gene

Relevant External Links for NNAT Gene

HapMap Linkage Disequilibrium report
NNAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for NNAT Gene

Disorders for NNAT Gene

(1) Novoseek inferred disease relationships for NNAT Gene

Disease -log(P) Hits PubMed IDs
tumors 0.457 6
genes like me logo Genes that share disorders with NNAT: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for NNAT Gene

Publications for NNAT Gene

  1. Structure and organization of the human neuronatin gene. (PMID: 8660979) Dou D. … Joseph R. (Genomics 1996) 2 3 4 23
  2. Cloning of human neuronatin gene and its localization to chromosome- 20q 11.2-12: the deduced protein is a novel 'proteolipid'. (PMID: 8813377) Dou D. … Joseph R. (Brain Res. 1996) 3 4 23
  3. cDNA cloning and mRNA expression analysis of the human neuronatin. High level expression in human pituitary gland and pituitary adenomas. (PMID: 9356927) Usui H. … Kumanishi T. (J. Mol. Neurosci. 1997) 3 4 23
  4. Imprinted expression of neuronatin from modified BAC transgenes reveals regulation by distinct and distant enhancers. (PMID: 11476579) John R.M. … Surani M.A. (Dev. Biol. 2001) 3 23
  5. The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2. (PMID: 11543638) Evans H.K. … Jirtle R.L. (Genomics 2001) 3 23

Products for NNAT Gene

Sources for NNAT Gene

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