NNAT Gene
protein-coding GIFtS : 45
GCID: GC20 P036149
neuronatin
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Aliasesfor NNAT gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Neuronatin 1 Peg51 2
Export aliases for NNAT gene to outside databases Previous GC identifers: GC20P035878 GC20P035838 GC20P036788 GC20P036835 GC20P035583 GC20P032885
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Summariesfor NNAT gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for NNAT : The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of the BLCAP gene, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. Two transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Nov 2009) UniProtKB/Swiss-Prot: NNAT_HUMAN, Q16517 Function : May participate in the maintenance of segment identity in the hindbrain and pituitary development, andmaturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels
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Genomic Viewsfor NNAT gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NC_018931.1 NT_011362.10 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NNAT gene promoter: CREB E2F-1 E2F deltaCREB C/EBPalpha Other transcription factors Search SABiosciences Chromatin IP Primers for NNAT Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NNAT
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20q11.2-q12 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20q11.2-q12 NNAT Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20P036149: view genomic region
(about GC identifiers )
Start:
36,149,607 bp from pter
End:
36,152,092 bp from pter
Size:
2,486 bases
Orientation:
plus strand
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Proteinsfor NNAT gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NNAT_HUMAN, Q16517 (See
protein sequence )Recommended Name: Neuronatin Size : 81 amino acids; 9237 Da
Developmental stage : Abundant in 18-24 week old fetal brain. Postnatally its expression decline and only minimal levelswere present in adulthood
Secondary accessions : B2R558 E1P5V6 Q16596 Q5U0N3Alternative splicing : 2 isoforms : Q16517-1 Q16517-2 Explore the universe of human proteins at neXtProt for NNAT: NX_Q16517 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q16517 NNAT Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_005377.1 NP_859017.1 ENSEMBL proteins: ENSP00000062104 ENSP00000335497 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IEA --
NNAT for ontologies About GeneDecksing NNAT Antibody Products: Assay Products for NNAT:
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Protein
Domains / Familiesfor NNAT gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
NNAT for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q16517 ProtoNet protein and cluster: Q16517
UniProtKB/Swiss-Prot: NNAT_HUMAN, Q16517 Similarity : Belongs to the neuronatin family
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Functionfor NNAT gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: NNAT_HUMAN, Q16517 Function : May participate in the maintenance of segment identity in the hindbrain and pituitary development, andmaturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NNAT (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NNAT (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): NNAT (NM_005386 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NNAT Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NNAT
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NNAT
Animal Models: Mouse knock-out Nnat tm1Lex for NNAT 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Nnat) :
NNAT for phenotypes About GeneDecksing
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Pathways & Interactionsfor NNAT gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NNAT STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for NNAT (ENSP00000062104 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
NNAT for ontologies About GeneDecksing
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Drugs & Compoundsfor NNAT gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for NNAT Search CenterWatch for drugs/clinical trials and news about NNAT
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Transcriptsfor NNAT gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NNAT gene (2 alternative transcripts): NM_005386.2 NM_181689.1 Unigene Cluster for NNAT:
Neuronatin Hs.504703 [show with all ESTs ] Unigene Representative Sequence: BM466491 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000062104 (uc002xhd.3 uc002xhe.3 ) ENST00000346199 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NNAT (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NNAT (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): NNAT (NM_005386 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NNAT Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NNAT
Additional cDNA sequence: AB002392.1 AK312069.1 BC001768.1 BT019426.1 U25033.1 U25034.1
13 DOTS entries : DT.100816553 DT.100816566
DT.87004599 DT.95292760 DT.100816567 DT.120814387 DT.95292758 DT.97773674 DT.95292754 DT.92352360 DT.120814278 DT.120814384 DT.100704952 24/253 AceView cDNA sequences (see all 253 ):
AW163630 AW160435 CD105284 AI879211 CR599948 AW163029 AW161483 CD107582 AW160593 AI816122 AW205617 AI816345 AI638471 CR611594 AA297497 BX419564 CR593008 BU170613 AW163736 BC001768 BM479943 AA338548 AI929654 BF446759 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for NNAT About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d SP1 :       -         SP2 :     -   -         SP3 :     -          
ECgene alternative splicing isoforms for NNAT
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Expression for NNAT gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NNAT expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAGTTGTGGT
About this image NNAT expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See NNAT Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NNAT SOURCE GeneReport for Unigene cluster: Hs.504703 SABiosciences Custom PCR Arrays for NNAT Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NNATBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat NNAT QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NNAT QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NNAT In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NNAT
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Orthologsfor NNAT gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of human and mouse.
Orthologs for NNAT gene from 1/5 species (see all 5 ) About this table
ENSEMBL Gene Tree for NNAT (if available)TreeFam Gene Tree for NNAT (if available)
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Paralogsfor NNAT gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor NNAT gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 20 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for NNAT (36149607 - 36152092 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for NNAT: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NNAT
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Disorders
/ Diseasesfor NNAT gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
NNAT for disorders About GeneDecksing
OMIM gene information: 603106
OMIM disorders : --20/21 diseases for NNAT (see all 21 ): About MalaCards myxoid liposarcoma lafora disease liposarcoma small cell carcinoma pituitary adenoma phenylketonuria neuroendocrine carcinoma pituitary tumor acute leukemia adenoma medulloblastoma lung cancer obesity carcinoma leukemia neuroblastoma immunodeficiency thyroiditis pancreatitis prostatitis 1 Novoseek disease relationship for NNAT gene About this table
Export disorders for NNAT gene to outside databases
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Publicationsfor NNAT gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NNAT gene, integrated from 9 sources (see all 38 ): (articles sorted by number of sources associating them with NNAT) Utopia : connect your pdf to the dynamic world of online information
Structure and organization of the human neuronatin gene. (PubMed id 8660979) 1 , 2 , 3, 9 Dou D. and Joseph R. (1996) cDNA cloning and mRNA expression analysis of the human neuronatin. High level expression in human pituitary gland and pituitary adenomas. (PubMed id 9356927) 1 , 2 , 9 Usui H....Kumanishi T. (1997) Cloning of human neuronatin gene and its localization to chromosome- 20q 11.2-12: the deduced protein is a novel 'proteolipid'. (PubMed id 8813377) 1 , 2 , 9 Dou D. and Joseph R. (1996) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 1 , 2 Deloukas P....Rogers J. (2001) Loss of neuronatin expression is associated with prom oter hypermethylation in pituitary adenoma. (PubMed id 19218280) 1 , 9 Revill K....Farrell W.E. (2009) Hypermethylation of the imprinted NNAT locus occurs frequently in pediatric acute leukemia. (PubMed id 11960906) 1 , 9 Kuerbitz S.J....Gray T.A. (2002) Neuronatin expression and its clinicopathological significance in pulmonary non-small cell carcinoma. (PubMed id 17805055) 1 , 9 Uchihara T....Noguchi M. (2007) Imprinted expression of neuronatin from modified BAC transgenes reveals regulation by distinct and distant enhancers. (PubMed id 11476579) 1 , 9 John R.M....Surani M.A. (2001) Coexpression of neuronatin splice forms promotes medulloblastoma growth. (PubMed id 18701710) 1 , 9 Siu I.M....Riggins G.J. (2008)
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External Searches for NNAT gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NNAT gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NNAT gene
(According to HUGE )
About This Section --
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Specialized Databases showing NNAT gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for NNAT Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NNAT gene: Search GeneIP for patents involving NNAT GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NNAT gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for NNAT OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for NNAT OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NNAT OriGene Protein Over-expression Lysate for NNAT Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for NNAT OriGene 3'-UTR Clone for NNAT OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NNAT OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NNAT Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for NNAT OriGene Custom Protein Services for NNAT OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NNAT QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NNAT QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NNAT QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat NNAT QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NNAT QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NNAT
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NNAT Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NNAT
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NNAT
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