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Aliases for NNAT Gene

Aliases for NNAT Gene

  • Neuronatin 2 3 3 5
  • Peg5 3

External Ids for NNAT Gene

Previous GeneCards Identifiers for NNAT Gene

  • GC20P035878
  • GC20P035838
  • GC20P036788
  • GC20P036835
  • GC20P035583
  • GC20P036149
  • GC20P032885

Summaries for NNAT Gene

Entrez Gene Summary for NNAT Gene

  • The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of another gene, bladder cancer associated protein, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. [provided by RefSeq, Apr 2016]

GeneCards Summary for NNAT Gene

NNAT (Neuronatin) is a Protein Coding gene. Diseases associated with NNAT include Anterior Horn Cell Disease.

UniProtKB/Swiss-Prot for NNAT Gene

  • May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.

Additional gene information for NNAT Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NNAT Gene

Genomics for NNAT Gene

Regulatory Elements for NNAT Gene

Enhancers for NNAT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H037411 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -109.0 -109028 2 ARNT ZSCAN4 KLF17 YBX1 ZNF48 ZNF207 ZNF548 RUNX3 MCM3 OVOL3 RPN2 DSN1 RBL1 NNAT CTNNBL1 VSTM2L TLDC2 TGIF2 DLGAP4-AS1 GHRH
GH20H037405 1.6 FANTOM5 Ensembl ENCODE 5.1 -114.6 -114610 1.2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 PAF1 NNAT VSTM2L MROH8 RPL7AP14 GC20M037240
GH20H037421 0.6 FANTOM5 8.3 -99.2 -99163 0.4 ZFHX2 NONO POLR2A ZNF398 PRDM1 ZNF18 EGR2 RPN2 RBL1 TTI1 VSTM2L NNAT RPL7AP14 GC20M037240
GH20H037921 0.8 FANTOM5 4.9 +400.7 400739 0.3 ZNF146 TBL1XR1 BATF RELA EED RUNX3 IKZF2 CREM SMARCA5 MAZ RPRD1B TTI1 NNAT VSTM2L RN7SKP185 GC20M037976
GH20H037985 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.6 +468.5 468527 8.1 HDGF PKNOX1 FOXA2 ARID4B YY1 TCF12 GATA2 ATF7 RUNX3 JUNB TGM2 VSTM2L RPRD1B TTI1 RALGAPB NNAT RN7SKP185 GC20M037976 GC20M037959
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NNAT on UCSC Golden Path with GeneCards custom track

Genomic Locations for NNAT Gene

Genomic Locations for NNAT Gene
chr20:37,521,205-37,523,693
(GRCh38/hg38)
Size:
2,489 bases
Orientation:
Plus strand
chr20:36,149,607-36,152,092
(GRCh37/hg19)

Genomic View for NNAT Gene

Genes around NNAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NNAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NNAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NNAT Gene

Proteins for NNAT Gene

  • Protein details for NNAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16517-NNAT_HUMAN
    Recommended name:
    Neuronatin
    Protein Accession:
    Q16517
    Secondary Accessions:
    • B2R558
    • E1P5V6
    • Q16596
    • Q5U0N3

    Protein attributes for NNAT Gene

    Size:
    81 amino acids
    Molecular mass:
    9237 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NNAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NNAT Gene

Post-translational modifications for NNAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NNAT Gene

No data available for DME Specific Peptides for NNAT Gene

Domains & Families for NNAT Gene

Gene Families for NNAT Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NNAT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NNAT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16517

UniProtKB/Swiss-Prot:

NNAT_HUMAN :
  • Belongs to the neuronatin family.
Family:
  • Belongs to the neuronatin family.
genes like me logo Genes that share domains with NNAT: view

Function for NNAT Gene

Molecular function for NNAT Gene

UniProtKB/Swiss-Prot Function:
May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May function as a regulatory subunit of ion channels.
genes like me logo Genes that share phenotypes with NNAT: view

Animal Models for NNAT Gene

MGI Knock Outs for NNAT:

Animal Model Products

miRNA for NNAT Gene

miRTarBase miRNAs that target NNAT

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NNAT Gene

Localization for NNAT Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NNAT gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NNAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with NNAT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NNAT Gene

Pathways & Interactions for NNAT Gene

No Data Available

Interacting Proteins for NNAT Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000062104%0d%0a9606.ENSP00000345464%0d%0a
Selected Interacting proteins: Q16517-NNAT_HUMAN ENSP00000062104 for NNAT Gene via IID STRING

Gene Ontology (GO) - Biological Process for NNAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8813377
GO:0007275 multicellular organism development IEA --
GO:0007420 brain development IBA --
GO:0009249 protein lipoylation TAS 8813377
GO:0030182 neuron differentiation IEA --
genes like me logo Genes that share ontologies with NNAT: view

No data available for Pathways by source and SIGNOR curated interactions for NNAT Gene

Drugs & Compounds for NNAT Gene

No Compound Related Data Available

Transcripts for NNAT Gene

mRNA/cDNA for NNAT Gene

Unigene Clusters for NNAT Gene

Neuronatin:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NNAT Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - -
SP3: -

Relevant External Links for NNAT Gene

GeneLoc Exon Structure for
NNAT
ECgene alternative splicing isoforms for
NNAT

Expression for NNAT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NNAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NNAT Gene

This gene is overexpressed in Pituitary (x16.5), Brain - Nucleus accumbens (basal ganglia) (x8.4), Brain - Caudate (basal ganglia) (x4.8), and Brain - Putamen (basal ganglia) (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of NNAT Gene:

NNAT

SOURCE GeneReport for Unigene cluster for NNAT Gene:

Hs.504703

Evidence on tissue expression from TISSUES for NNAT Gene

  • Nervous system(4.9)
  • Eye(4.5)
genes like me logo Genes that share expression patterns with NNAT: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NNAT Gene

Orthologs for NNAT Gene

This gene was present in the common ancestor of mammals.

Orthologs for NNAT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NNAT 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia NNAT 34
  • 100 (a)
OneToOne
LOC609195 33
  • 96.71 (n)
mouse
(Mus musculus)
Mammalia Nnat 33 16 34
  • 96.71 (n)
rat
(Rattus norvegicus)
Mammalia Nnat 33
  • 96.3 (n)
cow
(Bos Taurus)
Mammalia NNAT 33 34
  • 94.65 (n)
Species where no ortholog for NNAT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NNAT Gene

ENSEMBL:
Gene Tree for NNAT (if available)
TreeFam:
Gene Tree for NNAT (if available)

Paralogs for NNAT Gene

No data available for Paralogs for NNAT Gene

Variants for NNAT Gene

Sequence variations from dbSNP and Humsavar for NNAT Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000075729 -- 37,519,405(+) CAGAC(-/AAAAAAAAAAAAAAAAAAAG)AAAAA intron-variant, upstream-variant-2KB
rs1000860076 -- 37,523,589(+) GTAAG(C/T)TCCTG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001312036 -- 37,523,894(+) AAAGA(A/G)AAAGG intron-variant, upstream-variant-2KB
rs1001895485 -- 37,520,105(+) CCTGA(A/C)CTCTG intron-variant, upstream-variant-2KB
rs1002304718 -- 37,523,008(+) GGGGG(A/G)ATAGG intron-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NNAT Gene

Variant ID Type Subtype PubMed ID
nsv585962 CNV loss 21841781
nsv1055206 CNV loss 25217958

Variation tolerance for NNAT Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NNAT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NNAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NNAT Gene

Disorders for NNAT Gene

MalaCards: The human disease database

(1) MalaCards diseases for NNAT Gene - From: DISEASES

Disorder Aliases PubMed IDs
anterior horn cell disease
- elite association - COSMIC cancer census association via MalaCards
Search NNAT in MalaCards View complete list of genes associated with diseases

Relevant External Links for NNAT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NNAT
genes like me logo Genes that share disorders with NNAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NNAT Gene

Publications for NNAT Gene

  1. Structure and organization of the human neuronatin gene. (PMID: 8660979) Dou D … Joseph R (Genomics 1996) 2 3 4 22 60
  2. cDNA cloning and mRNA expression analysis of the human neuronatin. High level expression in human pituitary gland and pituitary adenomas. (PMID: 9356927) Usui H … Kumanishi T (Journal of molecular neuroscience : MN 1997) 3 4 22 60
  3. Cloning of human neuronatin gene and its localization to chromosome-20q 11.2-12: the deduced protein is a novel "proteolipid'. (PMID: 8813377) Dou D … Joseph R (Brain research 1996) 3 4 22 60
  4. Neuronatin is a stress-responsive protein of rod photoreceptors. (PMID: 27109921) Shinde V … Gorbatyuk M (Neuroscience 2016) 2 3 60
  5. Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma. (PMID: 19218280) Revill K … Farrell WE (Endocrine-related cancer 2009) 3 22 60

Products for NNAT Gene

Sources for NNAT Gene

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