Aliases for NMUR2 Gene
External Ids for NMUR2 Gene
Previous HGNC Symbols for NMUR2 Gene
Previous GeneCards Identifiers for NMUR2 Gene
This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]
GeneCards Summary for NMUR2 Gene
NMUR2 (Neuromedin U Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and intracellular calcium activated chloride channel activity. An important paralog of this gene is GPR39.
UniProtKB/Swiss-Prot for NMUR2 Gene
Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes; NMU1 and NMU2. The two subtypes have distinct tissue distributions; NMU1 is expressed in the periphery (especially in the gastrointestinal tract), whilst NMU2 is expressed in the central nervous system (especially in the substantia nigra, medulla oblongata and pontine reticular formation). NMU receptors mediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causing hypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. The human genes encoding NMU1 and NMU2 are located on chromosomes 2q37.1 and 5q33.1 respectively.