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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NMUR2 Gene

protein-coding   GIFtS: 60
GCID: GC05M151751

Neuromedin U Receptor 2


(Previous symbol: NMU2R)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuromedin U Receptor 21 2     FM42 5
NMU2R1 2 3 5     FM-42
NMU-R22 3     TGR-12
TGR12 3     Growth Hormone Secretagogue Receptor Family, Member 42
G-Protein Coupled Receptor FM-42 3     Neuromedin-U Receptor 22
G-Protein Coupled Receptor TGR-12 3     

External Ids:    HGNC: 164541   Entrez Gene: 569232   Ensembl: ENSG000001329117   OMIM: 6051085   UniProtKB: Q9GZQ43   

Export aliases for NMUR2 gene to outside databases

Previous GC identifers: GC05M151801 GC05M146910


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NMUR2 Gene:
This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for
neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This
receptor plays an important role in the regulation of food intake and body weight. (provided by RefSeq, Jul 2008)

GeneCards Summary for NMUR2 Gene: 
NMUR2 (neuromedin U receptor 2) is a protein-coding gene. Diseases associated with NMUR2 include hypertension, and eosinophilia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and intracellular calcium activated chloride channel activity. An important paralog of this gene is GHSR.

UniProtKB/Swiss-Prot: NMUR2_HUMAN, Q9GZQ4
Function: Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity)

summary for NMUR2 Gene:
Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into
two subtypes; NMU1 and NMU2. The two subtypes have distinct tissue distributions; NMU1 is expressed in the
periphery (especially in the gastrointestinal tract), whilst NMU2 is expressed in the central nervous system
(especially in the substantia nigra, medulla oblongata and pontine reticular formation). NMU receptors
mediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causing
hypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. The human
genes encoding NMU1 and NMU2 are located on chromosomes 2q37.1 and 5q33.1 respectively.

Gene Wiki entry for NMUR2 (Neuromedin U receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NMUR2 gene promoter:
         Max1   Brachyury   CUTL1   MRF-2   Ik-3   LyF-1   En-1   c-Myc   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNMUR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NMUR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMUR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

NMUR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMUR2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M151751:  view genomic region     (about GC identifiers)

Start:
151,771,093 bp from pter      End:
151,812,929 bp from pter
Size:
41,837 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NMUR2_HUMAN, Q9GZQ4 (See protein sequence)
Recommended Name: Neuromedin-U receptor 2  
Size: 415 amino acids; 47696 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Sequence caution: Sequence=BAB13721.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q7LC54 Q96AM5 Q9NRA6

Explore the universe of human proteins at neXtProt for NMUR2: NX_Q9GZQ4

Explore proteomics data for NMUR2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9GZQ4

  • NMUR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NMUR2 Protein Expression
    REFSEQ proteins: NP_064552.3  
    ENSEMBL proteins: 
     ENSP00000255262  
    Reactome Protein details: Q9GZQ4
    Human Recombinant Protein Products for NMUR2: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for NMUR2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IDA10899166

    NMUR2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for NMUR2 
    Cloud-Clone Corp. CLIAs for NMUR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NMUR: GPCR / Class A : Neuromedin U receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: NMU2 receptor 
    Neuromedin U receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR005390 NeuromedU_rcpt
     IPR005392 NeuromedU_rcpt_2
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9GZQ4

    ProtoNet protein and cluster: Q9GZQ4

    2 Blocks protein domains:
    IPB005390 Neuromedin U receptor family signature
    IPB005392 Neuromedin U type 2 receptor signature


    UniProtKB/Swiss-Prot: NMUR2_HUMAN, Q9GZQ4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    NMUR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMUR2_HUMAN, Q9GZQ4
    Function: Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001607neuromedin U receptor activity IDA10887190
    GO:0004930G-protein coupled receptor activity TAS10894543
    GO:0005229intracellular calcium activated chloride channel activity IDA10899166
    GO:0005525GTP binding IDA10899166
    GO:0008188neuropeptide receptor activity ----
         
    NMUR2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NMUR2:
     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nmur2):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  integument 
     nervous system 

    NMUR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NMUR2: Nmur2tm1Lex Nmur2tm1.1Eege

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NMUR2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NMUR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NMUR2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NMUR2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMUR2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NMUR2:
    hsa-miR-128 hsa-miR-3681*
    SwitchGear 3'UTR luciferase reporter plasmidNMUR2 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMUR2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NMUR2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.37
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NMUR2
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    1 BioSystems Pathway for NMUR2
        GPCRs, Class A Rhodopsin-like


    5/9        Reactome Pathways for NMUR2 (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding


    1         Kegg Pathway  (Kegg details for NMUR2):
        Neuroactive ligand-receptor interaction


    NMUR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NMUR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/246 Interacting proteins for NMUR2 (Q9GZQ43 ENSP000002552624) via UniProtKB, MINT, STRING, and/or I2D (see all 246)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMUP486453, ENSP000002642184I2D: score=4 STRING: ENSP00000264218
    NMSQ5H8A33, ENSP000003660614I2D: score=2 STRING: ENSP00000366061
    ADCY2ENSP000003429524STRING: ENSP00000342952
    CCKENSP000003356574STRING: ENSP00000335657
    CHRM1ENSP000003064904STRING: ENSP00000306490
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002023reduction of food intake in response to dietary excess IEA--
    GO:0006816calcium ion transport IDA10899166
    GO:0006940regulation of smooth muscle contraction NAS10887190
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway IDA10899166

    NMUR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NMUR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NMUR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Neuromedin S (rat) Potent, endogenous NMU1 and NMU2 agonist [843782-19-4]
    Neuromedin U (rat) Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature [117505-80-3]

    10 IUPHAR Ligands for NMUR2 (NMU2 receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    neuromedin S-33
    AgonistFull agonist1015635449
    [125I]neuromedin U-25 (human)
    AgonistAgonist9.815292653 15331768
    neuromedin U-8
    AgonistFull agonist8.5 - 9.515292653 10894543 10899166
    neuromedin U-25
    AgonistFull agonist8.4 - 9.415292653 10894543 10899166 15331768
    neuromedin U-23
    AgonistFull agonist8.5 - 9.315292653 10894543 10899166
    [125I]neuromedin U-23 (rat)
    AgonistAgonist9.110899166
    [125I]neuromedin U-8 (pig)
    AgonistAgonist9.110899166
    neuromedin U-25
    AgonistFull agonist8.6 - 915292653 10894543 10899166
    neuromedin U-8
    AgonistAgonist8.115292653
    R-PSOP
    AntagonistAntagonist7.0419369576

    1 Novoseek inferred chemical compound relationship for NMUR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 34.1 1 15292653 (1)

    Search CenterWatch for drugs/clinical trials and news about NMUR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NMUR2 gene: 
    NM_020167.4  

    Unigene Cluster for NMUR2:

    Neuromedin U receptor 2
    Hs.731911  [show with all ESTs]
    Unigene Representative Sequence: NM_020167
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255262(uc003luv.2) ENST00000518933
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NMUR2:
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB041228.1 AF242874.1 AF272363.1 AF292402.1 BC016938.2 BC067776.1 

    2 DOTS entries:

    DT.203512  DT.438445 

    24/33 AceView cDNA sequences (see all 33):

    Z38158 AB041228 AF242874 F05108 F01358 AF272363 BC067776 F03770 
    BM737798 F07531 BM757366 BM743981 BM737757 BM737726 BC016938 NM_020167 
    BM740616 AI432384 W61169 AI023570 BM743978 AF292402 H11359 W61131 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NMUR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTGTATC
    NMUR2 Expression
    About this image


    See NMUR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NMUR2

    SOURCE GeneReport for Unigene cluster: Hs.731911

    UniProtKB/Swiss-Prot: NMUR2_HUMAN, Q9GZQ4
    Tissue specificity: Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular
    formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of
    peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland,
    thyroid gland, lung, trachea, spleen and thymus

        SABiosciences Expression via Pathway-Focused PCR Array including NMUR2: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMUR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NMUR2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmur21 , 5 neuromedin U receptor 21, 5 81.39(n)1
    79.95(a)1
      11 (33.39 cM)5
    2167491  NM_153079.41  NP_694719.21 
     560249875 
    chicken
    (Gallus gallus)
    Aves NMUR21 neuromedin U receptor 2 71.66(n)
    70.3(a)
      427636  XM_425209.3  XP_425209.2 
    lizard
    (Anolis carolinensis)
    Reptilia NMUR26
    Uncharacterized protein
    72(a)
    1 ↔ 1
    GL343248.1(581706-612498)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5667501 neuromedin-U receptor 2-like 59.25(n)
    53.96(a)
      566750  XM_690035.1  XP_695127.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG87951 CG8795 51.8(n)
    40.29(a)
      41638  NM_169505.1  NP_731788.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nmur-11 Protein NMUR-1 45.75(n)
    34.97(a)
      183574  NM_077114.1  NP_509515.1 


    ENSEMBL Gene Tree for NMUR2 (if available)
    TreeFam Gene Tree for NMUR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NMUR2 gene
    GHSR2  NTSR12  GPR392  NMUR12  MLNR2  TRHR2  NTSR22  
    9 SIMAP similar genes for NMUR2 using alignment to 1 protein entry:     NMUR2_HUMAN:
    NMUR1    GHSR    GIR    NTSR1    DRD2    DRD3
    MLNR    hA2aR    OPRM1

    NMUR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/426 SNPs in NMUR2 are shown (see all 426)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727914251,2
    C--151770646(+) TTTGTA/GTCAGC 1 -- ds50013Minor allele frequency- G:0.11NA EA 242
    rs748544191,2
    F--151770687(+) TTATGT/AGTTCA 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs1900783801,2
    --151770918(+) AATATC/TGTTTT 1 -- ds50010--------
    rs559117051,2
    C,F--151770988(+) GAACAG/ATCAGA 1 -- ds50012Minor allele frequency- A:0.12NA EA 240
    rs560748691,2
    C,F--151770989(+) AACAGT/ACAGAA 1 -- ds50012Minor allele frequency- A:0.12NA EA 240
    rs1475009921,2
    C--151771011(+) TTATTA/CAGCTC 1 -- ds50010--------
    rs1485650611,2
    C--151771072(+) TAATAC/TCAAAG 1 -- ds50010--------
    rs9827141,2
    C,F,H--151771103(+) ATAAGC/TACATA 1 -- ut3124Minor allele frequency- T:0.10NS NA EA 2346
    rs737996151,2
    C--151771131(+) ATTGCG/AAAAAT 1 -- ut313Minor allele frequency- A:0.07WA EA 240
    rs9827151,2
    C,F,H--151771186(+) GAAGAA/CAGATG 1 -- ut31 trp316Minor allele frequency- C:0.10NA NS EA 2004

    HapMap Linkage Disequilibrium report for NMUR2 (151771093 - 151812929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NMUR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883048CNV Loss21882294
    nsv830519CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605108    OMIM disorders: --

    4 diseases for NMUR2:    About MalaCards
    hypertension    eosinophilia    obesity    thyroiditis


    NMUR2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NMUR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 5.96 3 15525579 (2), 16111886 (1)

    Genetic Association Database (GAD): NMUR2

    Export disorders for NMUR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NMUR2 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with NMUR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of receptors for neuromedin U and its role in feeding. (PubMed id 10894543)1, 2, 3 Howard A.D....Liu Q. (2000)
    2. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. (PubMed id 11010960)1, 2, 9 Shan L.... Hedrick J.A. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification and functional characterization of a novel subtype of neuromedin U receptor. (PubMed id 10887190)1, 2 Hosoya M....Fujino M. (2000)
    5. Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. (PubMed id 10899166)1, 2 Raddatz R....Adham N. (2000)
    6. Heterologous expression of G-protein-coupled receptors. (PubMed id 8940772)1, 3 Tate C.G. and Grisshammer R. (1996)
    7. Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones. (PubMed id 16781063)1, 9 Fang L....Hu Y. (2006)
    8. Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. (PubMed id 15525579)1, 9 Bhattacharyya S....O'Rahilly S. (2004)
    9. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (2012)
    10. Genome-wide association identifies ATOH7 as a major g ene determining human optic disc size. (PubMed id 20395239)1 Macgregor S....Mackey D.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56923 HGNC: 16454 AceView: NMUR2 Ensembl:ENSG00000132911 euGenes: HUgn56923
    ECgene: NMUR2 Kegg: 56923 H-InvDB: NMUR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NMUR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NMUR2 gene:
    Search GeneIP for patents involving NMUR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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