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Aliases for NMUR2 Gene

Aliases for NMUR2 Gene

  • Neuromedin U Receptor 2 2 3 5
  • G-Protein Coupled Receptor TGR-1 3 4
  • G-Protein Coupled Receptor FM-4 3 4
  • NMU-R2 3 4
  • NMU2R 3 4
  • TGR1 3 4
  • Growth Hormone Secretagogue Receptor Family, Member 4 3
  • TGR-1 3
  • FM-4 3
  • FM4 3

External Ids for NMUR2 Gene

Previous HGNC Symbols for NMUR2 Gene

  • NMU2R

Previous GeneCards Identifiers for NMUR2 Gene

  • GC05M151801
  • GC05M151751
  • GC05M146910

Summaries for NMUR2 Gene

Entrez Gene Summary for NMUR2 Gene

  • This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

GeneCards Summary for NMUR2 Gene

NMUR2 (Neuromedin U Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide receptor activity. An important paralog of this gene is GPR39.

UniProtKB/Swiss-Prot for NMUR2 Gene

  • Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Tocris Summary for NMUR2 Gene

  • Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes: NMU1 and NMU2. The two subtypes have distinct tissue distributions: NMU1 is expressed in the periphery, whilst NMU2 is expressed in the CNS.

Gene Wiki entry for NMUR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMUR2 Gene

Genomics for NMUR2 Gene

Regulatory Elements for NMUR2 Gene

Genomic Location for NMUR2 Gene

Chromosome:
5
Start:
152,391,532 bp from pter
End:
152,433,368 bp from pter
Size:
41,837 bases
Orientation:
Minus strand

Genomic View for NMUR2 Gene

Genes around NMUR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMUR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMUR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMUR2 Gene

Proteins for NMUR2 Gene

  • Protein details for NMUR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ4-NMUR2_HUMAN
    Recommended name:
    Neuromedin-U receptor 2
    Protein Accession:
    Q9GZQ4
    Secondary Accessions:
    • Q7LC54
    • Q96AM5
    • Q9NRA6

    Protein attributes for NMUR2 Gene

    Size:
    415 amino acids
    Molecular mass:
    47696 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13721.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NMUR2 Gene

Proteomics data for NMUR2 Gene at MOPED

Post-translational modifications for NMUR2 Gene

  • Glycosylation at Asn 9, Asn 27, and Asn 194
  • Modification sites at PhosphoSitePlus

Other Protein References for NMUR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NMUR2 Gene

Domains & Families for NMUR2 Gene

Gene Families for NMUR2 Gene

Suggested Antigen Peptide Sequences for NMUR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZQ4

UniProtKB/Swiss-Prot:

NMUR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NMUR2: view

Function for NMUR2 Gene

Molecular function for NMUR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Gene Ontology (GO) - Molecular Function for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IDA 10899166
genes like me logo Genes that share ontologies with NMUR2: view
genes like me logo Genes that share phenotypes with NMUR2: view

Animal Models for NMUR2 Gene

MGI Knock Outs for NMUR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NMUR2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NMUR2 Gene

Localization for NMUR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMUR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMUR2 Gene COMPARTMENTS Subcellular localization image for NMUR2 gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
vacuole 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NMUR2: view

Pathways & Interactions for NMUR2 Gene

genes like me logo Genes that share pathways with NMUR2: view

Pathways by source for NMUR2 Gene

SIGNOR curated interactions for NMUR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002023 reduction of food intake in response to dietary excess IEA --
GO:0006821 chloride transport IDA 10899166
GO:0006940 regulation of smooth muscle contraction NAS 10887190
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 10899166
genes like me logo Genes that share ontologies with NMUR2: view

Drugs & Compounds for NMUR2 Gene

(9) Drugs for NMUR2 Gene - From: IUPHAR, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]neuromedin U-23 (rat) Pharma Agonist 0
[<sup>125</sup>I]neuromedin U-25 (human) Pharma Agonist 0
[<sup>125</sup>I]neuromedin U-8 (pig) Pharma Agonist 0
neuromedin S-33 Pharma Full agonist, Agonist 0
neuromedin U-23 Pharma Full agonist, Agonist 0

(2) Additional Compounds for NMUR2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Neuromedin S (rat)
843782-19-4
Neuromedin U (rat)
117505-80-3

(2) Tocris Compounds for NMUR2 Gene

Compound Action Cas Number
Neuromedin S (rat) Potent, endogenous NMU1 and NMU2 agonist 843782-19-4
Neuromedin U (rat) Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature 117505-80-3
genes like me logo Genes that share compounds with NMUR2: view

Transcripts for NMUR2 Gene

mRNA/cDNA for NMUR2 Gene

Unigene Clusters for NMUR2 Gene

Neuromedin U receptor 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMUR2 Gene

No ASD Table

Relevant External Links for NMUR2 Gene

GeneLoc Exon Structure for
NMUR2
ECgene alternative splicing isoforms for
NMUR2

Expression for NMUR2 Gene

mRNA expression in normal human tissues for NMUR2 Gene

mRNA differential expression in normal tissues according to GTEx for NMUR2 Gene

This gene is overexpressed in Testis (x10.2), Brain - Spinal cord (cervical c-1) (x8.5), and Brain - Hypothalamus (x6.1).

SOURCE GeneReport for Unigene cluster for NMUR2 Gene Hs.731911

mRNA Expression by UniProt/SwissProt for NMUR2 Gene

Q9GZQ4-NMUR2_HUMAN
Tissue specificity: Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus.
genes like me logo Genes that share expression patterns with NMUR2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NMUR2 Gene

Orthologs for NMUR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NMUR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NMUR2 35
  • 85.79 (n)
  • 81.3 (a)
NMUR2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMUR2 35
  • 87.7 (n)
  • 84.04 (a)
NMUR2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmur2 35
  • 81.39 (n)
  • 79.95 (a)
Nmur2 16
Nmur2 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NMUR2 35
  • 98.55 (n)
  • 97.11 (a)
NMUR2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmur2 35
  • 80.76 (n)
  • 80.15 (a)
oppossum
(Monodelphis domestica)
Mammalia NMUR2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMUR2 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMUR2 35
  • 71.66 (n)
  • 70.3 (a)
NMUR2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMUR2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmur2 35
  • 67.77 (n)
  • 66.5 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC566750 35
  • 57.97 (n)
  • 52.2 (a)
BX248318.1 36
  • 50 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta capaR 35
  • 49.58 (n)
  • 35.67 (a)
capaR 36
  • 25 (a)
ManyToMany
CG8784 36
  • 18 (a)
ManyToMany
CG8795 36
  • 19 (a)
ManyToMany
Pk1r 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nmur-1 35
  • 45.75 (n)
  • 34.97 (a)
nmur-1 36
  • 26 (a)
ManyToMany
nmur-2 36
  • 30 (a)
ManyToMany
nmur-3 36
  • 20 (a)
ManyToMany
nmur-4 36
  • 25 (a)
ManyToMany
Species with no ortholog for NMUR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMUR2 Gene

ENSEMBL:
Gene Tree for NMUR2 (if available)
TreeFam:
Gene Tree for NMUR2 (if available)

Paralogs for NMUR2 Gene

Paralogs for NMUR2 Gene

(9) SIMAP similar genes for NMUR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NMUR2: view

Variants for NMUR2 Gene

Sequence variations from dbSNP and Humsavar for NMUR2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs4958535 - 152,395,503(+) ATTCA(A/C/G)TCCAC intron-variant, reference, missense
rs1895245 - 152,392,494(+) TAGAA(A/G/T)AAGAC reference, missense, utr-variant-3-prime
rs4958531 - 152,392,277(+) GTGCA(C/T)GGATG downstream-variant-500B, reference, missense
rs1363422 - 152,392,256(+) GGCTG(C/T)TGGGA downstream-variant-500B, reference, missense
rs4958532 - 152,392,291(+) GACAT(A/G)GGAAT downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NMUR2 Gene

Variant ID Type Subtype PubMed ID
nsv830519 CNV Loss 17160897
nsv883048 CNV Loss 21882294

Variation tolerance for NMUR2 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMUR2 Gene

HapMap Linkage Disequilibrium report
NMUR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMUR2 Gene

Disorders for NMUR2 Gene

Relevant External Links for NMUR2

Genetic Association Database (GAD)
NMUR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMUR2

No disorders were found for NMUR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMUR2 Gene

Publications for NMUR2 Gene

  1. Identification of receptors for neuromedin U and its role in feeding. (PMID: 10894543) Howard A.D. … Liu Q. (Nature 2000) 2 3 4 67
  2. Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones. (PMID: 16781063) Fang L. … Hu Y. (Neurosci. Lett. 2006) 3 23
  3. Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. (PMID: 15525579) Bhattacharyya S. … O'Rahilly S. (J. Endocrinol. 2004) 3 23
  4. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. (PMID: 11010960) Shan L. … Hedrick J.A. (J. Biol. Chem. 2000) 3 23
  5. Heterologous expression of G-protein-coupled receptors. (PMID: 8940772) Tate C.G. … Grisshammer R. (Trends Biotechnol. 1996) 2 3

Products for NMUR2 Gene

Sources for NMUR2 Gene

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