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Aliases for NMUR2 Gene

Aliases for NMUR2 Gene

  • Neuromedin U Receptor 2 2 3
  • NMU2R 3 4 6
  • G-Protein Coupled Receptor TGR-1 3 4
  • G-Protein Coupled Receptor FM-4 3 4
  • NMU-R2 3 4
  • TGR1 3 4
  • FM4 3 6
  • Growth Hormone Secretagogue Receptor Family, Member 4 3
  • Neuromedin-U Receptor 2 3
  • TGR-1 3
  • FM-4 3

External Ids for NMUR2 Gene

Previous Symbols for NMUR2 Gene

  • NMU2R

Summaries for NMUR2 Gene

Entrez Gene Summary for NMUR2 Gene

  • This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

GeneCards Summary for NMUR2 Gene

NMUR2 (Neuromedin U Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and intracellular calcium activated chloride channel activity. An important paralog of this gene is GPR39.

UniProtKB/Swiss-Prot for NMUR2 Gene

  • Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Tocris Summary for NMUR2 Gene

  • Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes; NMU1 and NMU2. The two subtypes have distinct tissue distributions; NMU1 is expressed in the periphery (especially in the gastrointestinal tract), whilst NMU2 is expressed in the central nervous system (especially in the substantia nigra, medulla oblongata and pontine reticular formation). NMU receptors mediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causing hypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. The human genes encoding NMU1 and NMU2 are located on chromosomes 2q37.1 and 5q33.1 respectively.

Gene Wiki entry for NMUR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMUR2 Gene

Genomics for NMUR2 Gene

Genomic Location for NMUR2 Gene

Start:
152,391,532 bp from pter
End:
152,433,368 bp from pter
Size:
41,837 bases
Orientation:
Minus strand

Genomic View for NMUR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMUR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMUR2 Gene

Regulatory Elements for NMUR2 Gene

Proteins for NMUR2 Gene

  • Protein details for NMUR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ4-NMUR2_HUMAN
    Recommended name:
    Neuromedin-U receptor 2
    Protein Accession:
    Q9GZQ4
    Secondary Accessions:
    • Q7LC54
    • Q96AM5
    • Q9NRA6

    Protein attributes for NMUR2 Gene

    Size:
    415 amino acids
    Molecular mass:
    47696 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13721.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NMUR2 Gene

Proteomics data for NMUR2 Gene at MOPED

Post-translational modifications for NMUR2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn9, Asn27, and Asn194

Other Protein References for NMUR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NMUR2 Gene

Domains for NMUR2 Gene

Gene Families for NMUR2 Gene

HGNC:
  • NMUR :GPCR / Class A : Neuromedin U receptors
IUPHAR :

UniProtKB/Swiss-Prot:

NMUR2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9GZQ4
genes like me logo Genes that share domains with NMUR2: view

Function for NMUR2 Gene

Molecular function for NMUR2 Gene

UniProtKB/Swiss-Prot Function: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Gene Ontology (GO) - Molecular Function for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001607 neuromedin U receptor activity IDA 10887190
GO:0004930 G-protein coupled receptor activity TAS 10894543
GO:0005229 intracellular calcium activated chloride channel activity IDA 10899166
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IDA 10899166
genes like me logo Genes that share ontologies with NMUR2: view
genes like me logo Genes that share phenotypes with NMUR2: view

Animal Models for NMUR2 Gene

MGI Knock Outs for NMUR2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NMUR2 Gene

Localization for NMUR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMUR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMUR2 Gene COMPARTMENTS Subcellular localization image for NMUR2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IDA 10899166
genes like me logo Genes that share ontologies with NMUR2: view

Pathways for NMUR2 Gene

genes like me logo Genes that share pathways with NMUR2: view

Pathways by source for NMUR2 Gene

Gene Ontology (GO) - Biological Process for NMUR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002023 reduction of food intake in response to dietary excess IEA --
GO:0006816 calcium ion transport IDA 10899166
GO:0006821 chloride transport IDA 10899166
GO:0006940 regulation of smooth muscle contraction NAS 10887190
GO:0007186 G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with NMUR2: view

Compounds for NMUR2 Gene

(2) Tocris Compounds for NMUR2 Gene

Compound Action Cas Number
Neuromedin S (rat) Potent, endogenous NMU1 and NMU2 agonist [843782-19-4]
Neuromedin U (rat) Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature [117505-80-3]

(10) IUPHAR Ligand for NMUR2 Gene

Ligand Type Action Affinity Pubmed IDs
neuromedin S-33 Agonist Full agonist 10
[125I]neuromedin U-25 (human) Agonist Agonist 9.8
neuromedin U-8 Agonist Full agonist 9.5
neuromedin U-8 Agonist Full agonist 9.5
neuromedin U-25 Agonist Full agonist 9.4
neuromedin U-25 Agonist Full agonist 9.4
neuromedin U-23 Agonist Full agonist 9.3
[125I]neuromedin U-8 (pig) Agonist Agonist 9.1
[125I]neuromedin U-23 (rat) Agonist Agonist 9.1
R-PSOP Antagonist Antagonist 7.04

(1) Novoseek inferred chemical compound relationships for NMUR2 Gene

Compound -log(P) Hits PubMed IDs
forskolin 34.1 1
genes like me logo Genes that share compounds with NMUR2: view

Transcripts for NMUR2 Gene

mRNA/cDNA for NMUR2 Gene

Unigene Clusters for NMUR2 Gene

Neuromedin U receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMUR2 Gene

No ASD Table

Relevant External Links for NMUR2 Gene

GeneLoc Exon Structure for
NMUR2
ECgene alternative splicing isoforms for
NMUR2

Expression for NMUR2 Gene

mRNA expression in normal human tissues for NMUR2 Gene

mRNA differential expression in normal tissues according to GTEx for NMUR2 Gene

This gene is overexpressed in Testis (10.2), Brain - Spinal cord (cervical c-1) (8.5), and Brain - Hypothalamus (6.1).

SOURCE GeneReport for Unigene cluster for NMUR2 Gene Hs.731911

mRNA Expression by UniProt/SwissProt for NMUR2 Gene

Q9GZQ4-NMUR2_HUMAN
Tissue specificity: Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus.
genes like me logo Genes that share expressions with NMUR2: view

Orthologs for NMUR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NMUR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMUR2 36
  • 98.55 (n)
  • 97.11 (a)
NMUR2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NMUR2 36
  • 85.79 (n)
  • 81.3 (a)
NMUR2 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMUR2 36
  • 87.7 (n)
  • 84.04 (a)
NMUR2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmur2 36
  • 81.39 (n)
  • 79.95 (a)
Nmur2 16
Nmur2 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMUR2 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMUR2 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmur2 36
  • 80.76 (n)
  • 80.15 (a)
chicken
(Gallus gallus)
Aves NMUR2 36
  • 71.66 (n)
  • 70.3 (a)
NMUR2 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMUR2 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmur2 36
  • 67.77 (n)
  • 66.5 (a)
zebrafish
(Danio rerio)
Actinopterygii BX248318.1 37
  • 50 (a)
ManyToMany
LOC566750 36
  • 57.97 (n)
  • 52.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta capaR 36
  • 49.58 (n)
  • 35.67 (a)
capaR 37
  • 25 (a)
ManyToMany
CG8784 37
  • 18 (a)
ManyToMany
CG8795 37
  • 19 (a)
ManyToMany
Pk1r 37
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nmur-1 36
  • 45.75 (n)
  • 34.97 (a)
nmur-1 37
  • 26 (a)
ManyToMany
nmur-2 37
  • 30 (a)
ManyToMany
nmur-3 37
  • 20 (a)
ManyToMany
nmur-4 37
  • 25 (a)
ManyToMany
Species with no ortholog for NMUR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMUR2 Gene

ENSEMBL:
Gene Tree for NMUR2 (if available)
TreeFam:
Gene Tree for NMUR2 (if available)

Paralogs for NMUR2 Gene

Paralogs for NMUR2 Gene

Selected SIMAP similar genes for NMUR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NMUR2: view

Variants for NMUR2 Gene

Sequence variations from dbSNP and Humsavar for NMUR2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs716256 -- 152,398,340(-) AATCA(C/T)TTATC intron-variant
rs716257 -- 152,397,905(-) AGAGA(C/T)ATATA intron-variant
rs958955 -- 152,398,228(-) ATGAG(C/T)GTTTG intron-variant
rs982714 -- 152,391,542(+) ATAAG(C/T)ACATA utr-variant-3-prime
rs982715 -- 152,391,625(+) GAAGA(A/C)AGATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NMUR2 Gene

Variant ID Type Subtype PubMed ID
nsv830519 CNV Loss 17160897
nsv883048 CNV Loss 21882294

Relevant External Links for NMUR2 Gene

HapMap Linkage Disequilibrium report
NMUR2

Disorders for NMUR2 Gene

(1) Novoseek inferred disease relationships for NMUR2 Gene

Disease -log(P) Hits PubMed IDs
obesity 5.96 3

Relevant External Links for NMUR2

Genetic Association Database (GAD)
NMUR2
genes like me logo Genes that share disorders with NMUR2: view

No data available for UniProtKB/Swiss-Prot for NMUR2 Gene

Publications for NMUR2 Gene

  1. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. (PMID: 11010960) Shan L. … Hedrick J.A. (J. Biol. Chem. 2000) 3 4 23
  2. Identification of receptors for neuromedin U and its role in feeding. (PMID: 10894543) Howard A.D. … Liu Q. (Nature 2000) 2 3 4
  3. Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. (PMID: 10899166) Raddatz R. … Adham N. (J. Biol. Chem. 2000) 3 4
  4. Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor. (PMID: 15525579) Bhattacharyya S. … O'Rahilly S. (J. Endocrinol. 2004) 3 23
  5. Heterologous expression of G-protein-coupled receptors. (PMID: 8940772) Tate C.G. … Grisshammer R. (Trends Biotechnol. 1996) 2 3

Products for NMUR2 Gene

Sources for NMUR2 Gene

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