Aliases for NMUR1 Gene
External Ids for NMUR1 Gene
Previous HGNC Symbols for NMUR1 Gene
Previous GeneCards Identifiers for NMUR1 Gene
GeneCards Summary for NMUR1 Gene
NMUR1 (Neuromedin U Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and neuromedin U receptor activity. An important paralog of this gene is GPR39.
UniProtKB/Swiss-Prot for NMUR1 Gene
Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes; NMU1 and NMU2. The two subtypes have distinct tissue distributions; NMU1 is expressed in the periphery (especially in the gastrointestinal tract), whilst NMU2 is expressed in the central nervous system (especially in the substantia nigra, medulla oblongata and pontine reticular formation). NMU receptors mediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causing hypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. The human genes encoding NMU1 and NMU2 are located on chromosomes 2q37.1 and 5q33.1 respectively.