Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NMUR1 Gene

Aliases for NMUR1 Gene

  • Neuromedin U Receptor 1 2 3
  • GPR66 3 4 6
  • G-Protein Coupled Receptor FM-3 3 4
  • G Protein-Coupled Receptor 66 2 3
  • G-Protein Coupled Receptor 66 3 4
  • NMU-R1 3 4
  • FM3 3 6
  • Neuromedin-U Receptor 1 3
  • (FM-3) 3
  • GPC-R 3
  • NMU1R 3
  • FM-3 3

External Ids for NMUR1 Gene

Previous Symbols for NMUR1 Gene

  • GPR66

Summaries for NMUR1 Gene

GeneCards Summary for NMUR1 Gene

NMUR1 (Neuromedin U Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and neuromedin U receptor activity. An important paralog of this gene is GPR39.

UniProtKB/Swiss-Prot for NMUR1 Gene

  • Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Tocris Summary for NMUR1 Gene

  • Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes; NMU1 and NMU2. The two subtypes have distinct tissue distributions; NMU1 is expressed in the periphery (especially in the gastrointestinal tract), whilst NMU2 is expressed in the central nervous system (especially in the substantia nigra, medulla oblongata and pontine reticular formation). NMU receptors mediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causing hypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. The human genes encoding NMU1 and NMU2 are located on chromosomes 2q37.1 and 5q33.1 respectively.

Gene Wiki entry for NMUR1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMUR1 Gene

Genomics for NMUR1 Gene

Genomic Location for NMUR1 Gene

Start:
231,520,257 bp from pter
End:
231,530,495 bp from pter
Size:
10,239 bases
Orientation:
Minus strand

Genomic View for NMUR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMUR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMUR1 Gene

Regulatory Elements for NMUR1 Gene

Proteins for NMUR1 Gene

  • Protein details for NMUR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB89-NMUR1_HUMAN
    Recommended name:
    Neuromedin-U receptor 1
    Protein Accession:
    Q9HB89
    Secondary Accessions:
    • O43664
    • Q7LDP6
    • Q8NE20

    Protein attributes for NMUR1 Gene

    Size:
    426 amino acids
    Molecular mass:
    47351 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMUR1 Gene

Proteomics data for NMUR1 Gene at MOPED

Post-translational modifications for NMUR1 Gene

  • Glycosylation at Asn7, Asn27, and Asn41

Other Protein References for NMUR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NMUR1 Gene

Domains for NMUR1 Gene

Gene Families for NMUR1 Gene

HGNC:
  • NMUR :GPCR / Class A : Neuromedin U receptors
IUPHAR :

UniProtKB/Swiss-Prot:

NMUR1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9HB89
genes like me logo Genes that share domains with NMUR1: view

Function for NMUR1 Gene

Molecular function for NMUR1 Gene

UniProtKB/Swiss-Prot Function: Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Gene Ontology (GO) - Molecular Function for NMUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001607 neuromedin U receptor activity IDA 10899166
GO:0004930 G-protein coupled receptor activity TAS 10899166
GO:0008188 neuropeptide receptor activity TAS 10811630
genes like me logo Genes that share ontologies with NMUR1: view
genes like me logo Genes that share phenotypes with NMUR1: view

Animal Models for NMUR1 Gene

MGI Knock Outs for NMUR1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NMUR1 Gene

Localization for NMUR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMUR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMUR1 Gene COMPARTMENTS Subcellular localization image for NMUR1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for NMUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9782091
GO:0016021 integral component of membrane IDA 10899166
genes like me logo Genes that share ontologies with NMUR1: view

Pathways for NMUR1 Gene

genes like me logo Genes that share pathways with NMUR1: view

Pathways by source for NMUR1 Gene

Gene Ontology (GO) - Biological Process for NMUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IDA 10899166
GO:0006821 chloride transport IDA 10899166
GO:0006939 smooth muscle contraction IEP 10899166
GO:0007186 G-protein coupled receptor signaling pathway TAS 9782091
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA 10899166
genes like me logo Genes that share ontologies with NMUR1: view

Compounds for NMUR1 Gene

(2) Tocris Compounds for NMUR1 Gene

Compound Action Cas Number
Neuromedin S (rat) Potent, endogenous NMU1 and NMU2 agonist [843782-19-4]
Neuromedin U (rat) Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature [117505-80-3]

(9) IUPHAR Ligand for NMUR1 Gene

Ligand Type Action Affinity Pubmed IDs
neuromedin S-33 Agonist Full agonist 10
[125I]neuromedin U-25 (human) Agonist Agonist 9.8
neuromedin U-8 Agonist Full agonist 9.5
neuromedin U-8 Agonist Full agonist 9.5
neuromedin U-25 Agonist Full agonist 9.4
neuromedin U-25 Agonist Full agonist 9.4
neuromedin U-23 Agonist Full agonist 9.3
[125I]neuromedin U-23 (rat) Agonist Agonist 9.1
[125I]neuromedin U-8 (pig) Agonist Agonist 9.1

(20) Novoseek inferred chemical compound relationships for NMUR1 Gene

Compound -log(P) Hits PubMed IDs
npff 69.1 2
inositol 1,4,5 trisphosphate 42.1 3
calcium 35.9 10
tyrosine 33.5 6
inositol 31.7 2
genes like me logo Genes that share compounds with NMUR1: view

Transcripts for NMUR1 Gene

mRNA/cDNA for NMUR1 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NMUR1 Gene

Neuromedin U receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMUR1 Gene

No ASD Table

Relevant External Links for NMUR1 Gene

GeneLoc Exon Structure for
NMUR1
ECgene alternative splicing isoforms for
NMUR1

Expression for NMUR1 Gene

mRNA expression in normal human tissues for NMUR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMUR1 Gene

This gene is overexpressed in Whole Blood (10.1).

SOURCE GeneReport for Unigene cluster for NMUR1 Gene Hs.471619

mRNA Expression by UniProt/SwissProt for NMUR1 Gene

Q9HB89-NMUR1_HUMAN
Tissue specificity: Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.
genes like me logo Genes that share expressions with NMUR1: view

Orthologs for NMUR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NMUR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMUR1 36
  • 99.45 (n)
  • 99.53 (a)
NMUR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NMUR1 36
  • 83.77 (n)
  • 77.91 (a)
NMUR1 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMUR1 36
  • 83.97 (n)
  • 80.38 (a)
NMUR1 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmur1 36
  • 78.41 (n)
  • 73.45 (a)
Nmur1 16
Nmur1 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMUR1 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMUR1 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmur1 36
  • 76.55 (n)
  • 71.57 (a)
chicken
(Gallus gallus)
Aves NMUR1 36
  • 66.05 (n)
  • 59.89 (a)
NMUR1 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMUR1 37
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498264 36
  • 61.42 (n)
  • 60.22 (a)
zebrafish
(Danio rerio)
Actinopterygii nmur1 36
  • 63.97 (n)
  • 60.92 (a)
nmur1 37
  • 59 (a)
OneToMany
NMUR1 (1 of 2) 37
  • 51 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRGHP1 36
  • 52.21 (n)
  • 37.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta capaR 37
  • 27 (a)
ManyToMany
CG8784 37
  • 19 (a)
ManyToMany
CG8795 37
  • 20 (a)
ManyToMany
Pk1r 37
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nmur-1 37
  • 25 (a)
ManyToMany
nmur-2 37
  • 26 (a)
ManyToMany
nmur-3 37
  • 20 (a)
ManyToMany
nmur-4 37
  • 24 (a)
ManyToMany
Species with no ortholog for NMUR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMUR1 Gene

ENSEMBL:
Gene Tree for NMUR1 (if available)
TreeFam:
Gene Tree for NMUR1 (if available)

Paralogs for NMUR1 Gene

Paralogs for NMUR1 Gene

Selected SIMAP similar genes for NMUR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NMUR1: view

Variants for NMUR1 Gene

Sequence variations from dbSNP and Humsavar for NMUR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1868456 -- 231,520,664(-) TTCTT(C/G)TTCCA intron-variant
rs3070953 -- 231,530,563(+) CGGCC(A/G)TTGGA upstream-variant-2KB
rs3070981 -- 231,530,569(+) TTGGA(-/GGCGACACC)TCCAC upstream-variant-2KB
rs3752760 -- 231,524,818(+) GTGGA(C/G)AGATA utr-variant-3-prime, intron-variant
rs3752761 -- 231,524,819(+) TGGAC(A/G)GATAA utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMUR1 Gene

Variant ID Type Subtype PubMed ID
nsv834567 CNV Gain 17160897
nsv875966 CNV Gain 21882294
nsv875967 CNV Loss 21882294

Relevant External Links for NMUR1 Gene

HapMap Linkage Disequilibrium report
NMUR1

Disorders for NMUR1 Gene

(7) Novoseek inferred disease relationships for NMUR1 Gene

Disease -log(P) Hits PubMed IDs
cancer 1.48 3
tumors 0.641 2
obesity 0.0066 1
cardiovascular diseases 0 1
asthma 0 2

Relevant External Links for NMUR1

Genetic Association Database (GAD)
NMUR1
Human Genome Epidemiology (HuGE) Navigator
NMUR1
genes like me logo Genes that share disorders with NMUR1: view

No data available for UniProtKB/Swiss-Prot for NMUR1 Gene

Publications for NMUR1 Gene

  1. Cloning and characterization of a human and murine T-cell orphan G- protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors. (PMID: 9782091) Tan C.P. … Howard A.D. (Genomics 1998) 2 3 4 23
  2. Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. (PMID: 10899166) Raddatz R. … Adham N. (J. Biol. Chem. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. (PMID: 10783389) Fujii R. … Fujino M. (J. Biol. Chem. 2000) 3 23

Products for NMUR1 Gene

Sources for NMUR1 Gene

Back to Top

Content