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Aliases for NMUR1 Gene

Aliases for NMUR1 Gene

  • Neuromedin U Receptor 1 2 3 5
  • G-Protein Coupled Receptor FM-3 3 4
  • G Protein-Coupled Receptor 66 2 3
  • G-Protein Coupled Receptor 66 3 4
  • NMU-R1 3 4
  • GPR66 3 4
  • (FM-3) 3
  • GPC-R 3
  • NMU1R 3
  • FM-3 3
  • FM3 3

External Ids for NMUR1 Gene

Previous HGNC Symbols for NMUR1 Gene

  • GPR66

Previous GeneCards Identifiers for NMUR1 Gene

  • GC02M232591
  • GC02M232213
  • GC02M232096
  • GC02M232387
  • GC02M224229

Summaries for NMUR1 Gene

GeneCards Summary for NMUR1 Gene

NMUR1 (Neuromedin U Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and neuromedin U receptor activity. An important paralog of this gene is GPR39.

UniProtKB/Swiss-Prot for NMUR1 Gene

  • Receptor for the neuromedin-U and neuromedin-S neuropeptides.

Tocris Summary for NMUR1 Gene

  • Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes: NMU1 and NMU2. The two subtypes have distinct tissue distributions: NMU1 is expressed in the periphery, whilst NMU2 is expressed in the CNS.

Gene Wiki entry for NMUR1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMUR1 Gene

Genomics for NMUR1 Gene

Regulatory Elements for NMUR1 Gene

Enhancers for NMUR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NMUR1 on UCSC Golden Path with GeneCards custom track

Promoters for NMUR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NMUR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NMUR1 Gene

Chromosome:
2
Start:
231,519,907 bp from pter
End:
231,530,495 bp from pter
Size:
10,589 bases
Orientation:
Minus strand

Genomic View for NMUR1 Gene

Genes around NMUR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMUR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMUR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMUR1 Gene

Proteins for NMUR1 Gene

  • Protein details for NMUR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB89-NMUR1_HUMAN
    Recommended name:
    Neuromedin-U receptor 1
    Protein Accession:
    Q9HB89
    Secondary Accessions:
    • O43664
    • Q7LDP6
    • Q8NE20

    Protein attributes for NMUR1 Gene

    Size:
    426 amino acids
    Molecular mass:
    47351 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMUR1 Gene

Proteomics data for NMUR1 Gene at MOPED

Post-translational modifications for NMUR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NMUR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NMUR1 Gene

Domains & Families for NMUR1 Gene

Gene Families for NMUR1 Gene

Suggested Antigen Peptide Sequences for NMUR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HB89

UniProtKB/Swiss-Prot:

NMUR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NMUR1: view

Function for NMUR1 Gene

Molecular function for NMUR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the neuromedin-U and neuromedin-S neuropeptides.
genes like me logo Genes that share phenotypes with NMUR1: view

Animal Models for NMUR1 Gene

MGI Knock Outs for NMUR1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMUR1 Gene

Localization for NMUR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMUR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMUR1 Gene COMPARTMENTS Subcellular localization image for NMUR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for NMUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 10899166
genes like me logo Genes that share ontologies with NMUR1: view

Pathways & Interactions for NMUR1 Gene

genes like me logo Genes that share pathways with NMUR1: view

SIGNOR curated interactions for NMUR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NMUR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IDA 10899166
GO:0006821 chloride transport IDA 10899166
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA 10899166
GO:0007218 neuropeptide signaling pathway TAS 10899166
GO:0048016 inositol phosphate-mediated signaling IDA 10899166
genes like me logo Genes that share ontologies with NMUR1: view

Drugs & Compounds for NMUR1 Gene

(18) Drugs for NMUR1 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I]neuromedin U-23 (rat) Pharma Agonist 0
[<sup>125</sup>I]neuromedin U-25 (human) Pharma Agonist 0
[<sup>125</sup>I]neuromedin U-8 (pig) Pharma Agonist 0
neuromedin S-33 Pharma Full agonist, Agonist 0
neuromedin U-23 Pharma Full agonist, Agonist 0

(11) Additional Compounds for NMUR1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Neuromedin S (rat)
843782-19-4
Neuromedin U (rat)
117505-80-3

(2) Tocris Compounds for NMUR1 Gene

Compound Action Cas Number
Neuromedin S (rat) Potent, endogenous NMU1 and NMU2 agonist 843782-19-4
Neuromedin U (rat) Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature 117505-80-3
genes like me logo Genes that share compounds with NMUR1: view

Transcripts for NMUR1 Gene

mRNA/cDNA for NMUR1 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NMUR1 Gene

Neuromedin U receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMUR1 Gene

No ASD Table

Relevant External Links for NMUR1 Gene

GeneLoc Exon Structure for
NMUR1
ECgene alternative splicing isoforms for
NMUR1

Expression for NMUR1 Gene

mRNA expression in normal human tissues for NMUR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMUR1 Gene

This gene is overexpressed in Whole Blood (x10.1).

SOURCE GeneReport for Unigene cluster for NMUR1 Gene Hs.471619

mRNA Expression by UniProt/SwissProt for NMUR1 Gene

Q9HB89-NMUR1_HUMAN
Tissue specificity: Expressed in greatest abundance in peripheral organs, particularly in elements of the gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord.
genes like me logo Genes that share expression patterns with NMUR1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NMUR1 Gene

Orthologs for NMUR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NMUR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NMUR1 35
  • 83.77 (n)
  • 77.91 (a)
NMUR1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMUR1 35
  • 83.97 (n)
  • 80.38 (a)
NMUR1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmur1 35
  • 78.41 (n)
  • 73.45 (a)
Nmur1 16
Nmur1 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NMUR1 35
  • 99.45 (n)
  • 99.53 (a)
NMUR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmur1 35
  • 76.55 (n)
  • 71.57 (a)
oppossum
(Monodelphis domestica)
Mammalia NMUR1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMUR1 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMUR1 35
  • 66.05 (n)
  • 59.89 (a)
NMUR1 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMUR1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498264 35
  • 61.42 (n)
  • 60.22 (a)
zebrafish
(Danio rerio)
Actinopterygii nmur1 35
  • 63.97 (n)
  • 60.92 (a)
nmur1 36
  • 59 (a)
OneToMany
NMUR1 (1 of 2) 36
  • 51 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRGHP1 35
  • 52.21 (n)
  • 37.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta capaR 36
  • 27 (a)
ManyToMany
CG8784 36
  • 19 (a)
ManyToMany
CG8795 36
  • 20 (a)
ManyToMany
Pk1r 36
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nmur-1 36
  • 25 (a)
ManyToMany
nmur-2 36
  • 26 (a)
ManyToMany
nmur-3 36
  • 20 (a)
ManyToMany
nmur-4 36
  • 24 (a)
ManyToMany
Species with no ortholog for NMUR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMUR1 Gene

ENSEMBL:
Gene Tree for NMUR1 (if available)
TreeFam:
Gene Tree for NMUR1 (if available)

Paralogs for NMUR1 Gene

Paralogs for NMUR1 Gene

(5) SIMAP similar genes for NMUR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NMUR1: view

Variants for NMUR1 Gene

Sequence variations from dbSNP and Humsavar for NMUR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1868456 -- 231,520,664(-) TTCTT(C/G)TTCCA intron-variant, utr-variant-3-prime
rs3070953 -- 231,530,563(+) CGGCC(A/G)TTGGA upstream-variant-2KB
rs3070981 -- 231,530,569(+) TTGGA(-/GGCGACACC)TCCAC upstream-variant-2KB
rs4973001 -- 231,520,800(+) ATGTG(C/T)AGTGC intron-variant, utr-variant-3-prime
rs4973002 -- 231,527,027(+) TGGTC(A/T)CTCCT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NMUR1 Gene

Variant ID Type Subtype PubMed ID
nsv834567 CNV Gain 17160897
nsv875966 CNV Gain 21882294
nsv875967 CNV Loss 21882294

Variation tolerance for NMUR1 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.00; 68.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMUR1 Gene

HapMap Linkage Disequilibrium report
NMUR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMUR1 Gene

Disorders for NMUR1 Gene

Relevant External Links for NMUR1

Genetic Association Database (GAD)
NMUR1
Human Genome Epidemiology (HuGE) Navigator
NMUR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMUR1

No disorders were found for NMUR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMUR1 Gene

Publications for NMUR1 Gene

  1. Cloning and characterization of a human and murine T-cell orphan G- protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors. (PMID: 9782091) Tan C.P. … Howard A.D. (Genomics 1998) 2 3 4 23 67
  2. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. (PMID: 10783389) Fujii R. … Fujino M. (J. Biol. Chem. 2000) 3 23
  3. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 3
  4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3
  5. Histamine acting on H1 receptor promotes inhibition of proliferation via PLC, RAC, and JNK-dependent pathways. (PMID: 19913013) Notcovich C. … Shayo C. (Exp. Cell Res. 2010) 23

Products for NMUR1 Gene

Sources for NMUR1 Gene

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