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NMUR1 Gene

protein-coding   GIFtS: 57
GCID: GC02M232387

Neuromedin U Receptor 1

(Previous name: G protein-coupled receptor 66)
(Previous symbol: GPR66)
  See NMUR1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuromedin U Receptor 11 2     FM32 5
GPR661 2 3 5     (FM-3)2
G Protein-Coupled Receptor 661 2     FM-32
NMU-R12 3     GPC-R2
G-Protein Coupled Receptor 662 3     NMU1R2
G-Protein Coupled Receptor FM-32 3     Neuromedin-U Receptor 12

External Ids:    HGNC: 45181   Entrez Gene: 103162   Ensembl: ENSG000001715967   OMIM: 6041535   UniProtKB: Q9HB893   

Export aliases for NMUR1 gene to outside databases

Previous GC identifers: GC02M232591 GC02M232213 GC02M232096 GC02M224229


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NMUR1 Gene:
NMUR1 (neuromedin U receptor 1) is a protein-coding gene. Diseases associated with NMUR1 include hypertension. GO annotations related to this gene include neuromedin U receptor activity and G-protein coupled receptor activity. An important paralog of this gene is GHSR.

UniProtKB/Swiss-Prot: NMUR1_HUMAN, Q9HB89
Function: Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity)

summary for NMUR1 Gene:
Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into
two subtypes; NMU1 and NMU2. The two subtypes have distinct tissue distributions; NMU1 is expressed in the
periphery (especially in the gastrointestinal tract), whilst NMU2 is expressed in the central nervous system
(especially in the substantia nigra, medulla oblongata and pontine reticular formation). NMU receptors
mediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causing
hypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. The human
genes encoding NMU1 and NMU2 are located on chromosomes 2q37.1 and 5q33.1 respectively.

Gene Wiki entry for NMUR1 (Neuromedin U receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NMUR1 gene promoter:
         AhR   AP-1   AML1a   HTF   Roaz   Arnt   HEN1   HOXA5   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNMUR1 promoter sequence
   Search Chromatin IP Primers for NMUR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NMUR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

NMUR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMUR1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M232387:  view genomic region     (about GC identifiers)

Start:
232,387,871 bp from pter      End:
232,395,206 bp from pter
Size:
7,336 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NMUR1_HUMAN, Q9HB89 (See protein sequence)
Recommended Name: Neuromedin-U receptor 1  
Size: 426 amino acids; 47351 Da
Caution: It is uncertain whether Met-1 or Met-24 is the initiator
Secondary accessions: O43664 Q7LDP6 Q8NE20

Explore the universe of human proteins at neXtProt for NMUR1: NX_Q9HB89

Explore proteomics data for NMUR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7, Asn27, Asn41

  • See NMUR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006047.3  
    ENSEMBL proteins: 
     ENSP00000305877  
    Reactome Protein details: Q9HB89

    NMUR1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NMUR: GPCR / Class A : Neuromedin U receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: NMU1 receptor
    Neuromedin U receptors

    4 InterPro protein domains:
     IPR005390 NeuromedU_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR005391 NeuromedU_rcpt_1

    Graphical View of Domain Structure for InterPro Entry Q9HB89

    ProtoNet protein and cluster: Q9HB89

    2 Blocks protein domains:
    IPB005390 Neuromedin U receptor family signature
    IPB005391 Neuromedin U type 1 receptor signature


    UniProtKB/Swiss-Prot: NMUR1_HUMAN, Q9HB89
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with NMUR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMUR1_HUMAN, Q9HB89
    Function: Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001607neuromedin U receptor activity IDA10899166
    GO:0004930G-protein coupled receptor activity TAS10899166
    GO:0008188neuropeptide receptor activity TAS10811630
         
    Find genes that share ontologies with NMUR1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nmur1):
     behavior/neurological  homeostasis/metabolism  integument  normal 

    Find genes that share phenotypes with NMUR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NMUR1: Nmur1tm1Rtor Nmur1tm1Lex Nmur1tm1Doma Nmur1tm1Sjab

       genOway: Develop your customized and physiologically relevant rodent model for NMUR1

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    SwitchGear 3'UTR luciferase reporter plasmidNMUR1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMUR1_HUMAN, Q9HB89: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9782091
    GO:0016021integral component of membrane IDA10899166

    Find genes that share ontologies with NMUR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NMUR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    5Calcium channels
    Calcium channels


    Find genes that share SuperPaths with NMUR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NMUR1
        GPCRs, Class A Rhodopsin-like

    3 Reactome Pathways for NMUR1
        Peptide ligand-binding receptors
    G alpha (q) signalling events
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for NMUR1):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NMUR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NMUR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NMUR1 (Q9HB893 ENSP000003058774) via UniProtKB, MINT, STRING, and/or I2D (see all 251)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMUP486453, ENSP000002642184I2D: score=4 STRING: ENSP00000264218
    NMSQ5H8A33, ENSP000003660614I2D: score=3 STRING: ENSP00000366061
    ADCY2ENSP000003429524STRING: ENSP00000342952
    AGTR2ENSP000003609734STRING: ENSP00000360973
    AVPR1AENSP000002991784STRING: ENSP00000299178
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport IDA10899166
    GO:0006821chloride transport IDA10899166
    GO:0006939smooth muscle contraction IEP10899166
    GO:0007186G-protein coupled receptor signaling pathway TAS9782091
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway IDA10899166

    Find genes that share ontologies with NMUR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NMUR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Neuromedin S (rat) Potent, endogenous NMU1 and NMU2 agonist [843782-19-4]
    Neuromedin U (rat) Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature [117505-80-3]

    9 IUPHAR Ligands for NMUR1 (NMU1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    neuromedin S-33
    AgonistFull agonist10.215635449
    [125I]neuromedin U-25 (human)
    AgonistAgonist9.9 - 10.115292653 15331768
    neuromedin U-8
    AgonistFull agonist9 - 1015292653 10894543 10899166
    [125I]neuromedin U-23 (rat)
    AgonistAgonist9.1 - 9.510894543 10899166
    neuromedin U-25
    AgonistFull agonist8.4 - 9.415292653 10894543 10899166 15331768
    neuromedin U-23
    AgonistFull agonist8.7 - 9.115292653 10894543 10899166
    neuromedin U-25
    AgonistFull agonist8.3 - 8.915292653 10894543 10899166
    [125I]neuromedin U-8 (pig)
    AgonistAgonist8.610899166
    neuromedin U-8
    AgonistAgonist8.515292653

    Selected Novoseek inferred chemical compound relationships for NMUR1 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    npff 69.1 2 10851242 (1), 11325803 (1)
    inositol 1,4,5 trisphosphate 42.1 3 16965760 (1), 17379645 (1), 20161830 (1)
    calcium 35.9 10 19513662 (2), 17895620 (2), 16965760 (1), 17638542 (1) (see all 8)
    tyrosine 33.5 7 16725308 (1), 11750876 (1), 16262259 (1), 16914291 (1) (see all 6)
    inositol 31.7 2 16965760 (1), 14723977 (1)
    histamine 30.4 2 19913013 (1), 18724073 (1)
    adenylate 30.4 1 17900700 (1)
    gnrh 29.8 2 9259312 (1), 17172315 (1)
    melatonin 22 2 18544139 (1)
    guanine 21.5 4 17638542 (1), 17900700 (1), 16930743 (1)



    Find genes that share compounds with NMUR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NMUR1 gene: 
    NM_006056.4  

    Unigene Cluster for NMUR1:

    Neuromedin U receptor 1
    Hs.471619  [show with all ESTs]
    Unigene Representative Sequence: BC036543
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000305141(uc002vry.4)
    miRNA
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    Additional mRNA sequence: 

    AF272362.1 AK300222.1 AK301102.1 BC036543.1 BC051914.1 

    3 DOTS entries:

    DT.97809062  DT.100697371  DT.100657458 

    13 AceView cDNA sequences:

    BP382356 BC051914 AF272362 CA412776 BM008157 NM_006056 BX491295 BQ721315 
    BX283968 BM711538 BC036543 BM665453 BI458633 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NMUR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGAAACTT
    NMUR1 Expression
    About this image


    NMUR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
    NMUR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NMUR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471619

    UniProtKB/Swiss-Prot: NMUR1_HUMAN, Q9HB89
    Tissue specificity: Expressed in greatest abundance in peripheral organs, particularly in elements of the
    gastrointestinal and urogenital systems with highest levels in testes. In central nervous system structures
    express levels are much lower than those seen in peripheral organs. Within the CNS, has been detected in highest
    abundance in the cerebellum, dorsal root ganglia, hippocampus, and spinal cord

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NMUR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMUR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NMUR1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmur11 , 5 neuromedin U receptor 11, 5 78.41(n)1
    73.45(a)1
      1 (43.94 cM)5
    147671  NM_010341.11  NP_034471.11 
     863862425 
    chicken
    (Gallus gallus)
    Aves NMUR11 neuromedin U receptor 1 66.05(n)
    59.89(a)
      429150  XM_004943371.1  XP_004943428.1 
    lizard
    (Anolis carolinensis)
    Reptilia NMUR16
    neuromedin U receptor 1
    54(a)
    1 ↔ 1
    GL343304.1(1473575-1492860)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004982641 neuromedin-U receptor 1-like 61.42(n)
    60.22(a)
      100498264  XM_002937350.2  XP_002937396.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nmur11 neuromedin U receptor 1 63.97(n)
    60.92(a)
      557276  XM_680313.4  XP_685405.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pk1r6
    capaR6
    (see all 4)
    capa receptor
    (see all 4)
    28(a)
    27(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    3R(9925554-9928844)
    3L(21552074-21555281)
    worm
    (Caenorhabditis elegans)
    Secernentea nmur-26
    nmur-16
    (see all 4)
    Protein NMUR-1 (nmur-1) mRNA, complete cds
    (see all 4)
    26(a)
    25(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    II(123339-125004) WBGene00019616
    X(8980976-8985063) WBGene00016747


    ENSEMBL Gene Tree for NMUR1 (if available)
    TreeFam Gene Tree for NMUR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NMUR1 gene
    GHSR2  NTSR12  GPR392  MLNR2  NMUR22  TRHR2  NTSR22  
    5 SIMAP similar genes for NMUR1 using alignment to 2 protein entries:     NMUR1_HUMAN (see all proteins):
    NMUR2    DRD3    NTSR1    GHSR    MLNR

    Find genes that share paralogs with NMUR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NMUR1 (see all 269)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862385941,2
    --231767216(+) CTAAAA/GAGCAG 1 -- us2k10--------
    rs2014962421,2
    --232387405(+) CAGGG-/CCCCCC 1 -- ds50010--------
    rs1145473221,2
    C,F--232387412(+) CCCCCA/GCTGAG 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1456597091,2
    --232387493(+) TTCTCC/TCATTT 1 -- ds50010--------
    rs1872691701,2
    C--232387532(+) CCCACA/CCCCAG 1 -- ds50010--------
    rs1157703111,2
    --232387630(+) CCCCGA/TGCCAG 1 -- ds50010--------
    rs729913371,2
    C,F--232387698(+) AGATGG/ATTTAT 1 -- ds50016Minor allele frequency- A:0.33NA CSA WA EA 364
    rs729913381,2
    C,F--232387706(+) TATGCA/GAGTCC 1 -- ds50016Minor allele frequency- G:0.33NA CSA WA EA 364
    rs1146901941,2
    C,F--232387773(+) GCAAGC/TGTGAG 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1383185721,2
    --232387794(+) ACATCA/CACTGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NMUR1 (232387871 - 232395206 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NMUR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875967CNV Loss21882294
    nsv834567CNV Gain17160897
    nsv875966CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NMUR1
    DNA2.0 Custom Variant and Variant Library Synthesis for NMUR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604153    OMIM disorders: --

    1 disease for NMUR1:    
    About MalaCards
    hypertension


    Find genes that share disorders with NMUR1           About GenesLikeMe

    7 Novoseek inferred disease relationships for NMUR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 1.48 3 17314506 (2), 17379645 (1)
    tumors 0.641 2 17314506 (2)
    obesity 0.0066 1 12769637 (1)
    cardiovascular diseases 0 1 16740128 (1)
    asthma 0 4 18278482 (1), 12648290 (1)
    inflammation 0 2 16740128 (1), 15778405 (1)
    ovarian cancer 0 1 15280385 (1)

    Genetic Association Database (GAD): NMUR1
    Human Genome Epidemiology (HuGE) Navigator: NMUR1 (1 document)

    Export disorders for NMUR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NMUR1 gene, integrated from 10 sources (see all 149):
    (articles sorted by number of sources associating them with NMUR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human and murine T-cell orphan G- protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors. (PubMed id 9782091)1, 2, 3, 9 Tan C.P.... Howard A.D. (Genomics 1998)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. (PubMed id 10899166)1, 2 Raddatz R....Adham N. (J. Biol. Chem. 2000)
    5. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. (PubMed id 10783389)1, 9 Fujii R....Fujino M. (J. Biol. Chem. 2000)
    6. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (Pharmacogenomics J. 2013)
    7. Dissociation of heterotrimeric g proteins in cells. (PubMed id 18577758)1 Lambert N.A. (Sci Signal 2008)
    8. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. (PubMed id 15635449)1 Mori K.... Kangawa K. (EMBO J. 2005)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10316 HGNC: 4518 AceView: NMUR1 Ensembl:ENSG00000171596 euGenes: HUgn10316
    ECgene: NMUR1 Kegg: 10316 H-InvDB: NMUR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NMUR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NMUR1 gene:
    Search GeneIP for patents involving NMUR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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