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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NMU Gene

protein-coding   GIFtS: 59
GCID: GC04M056461

Neuromedin U

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuromedin U1 2
prepro-NMU1 2
neuromedin-U2

External Ids:    HGNC: 78591   Entrez Gene: 108742   Ensembl: ENSG000001092557   OMIM: 6051035   UniProtKB: P486453   

Export aliases for NMU gene to outside databases

Previous GC identifers: GC04M056265 GC04M056422 GC04M056311 GC04M056376 GC04M056302 GC04M056156 GC04M052410


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NMU Gene: 
NMU (neuromedin U) is a protein-coding gene. Diseases associated with NMU include seminal vesicle adenocarcinoma, and eosinophilia, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include neuromedin U receptor binding and receptor binding.

UniProtKB/Swiss-Prot: NMU_HUMAN, P48645
Function: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU
stimulates contractions of the ileum and urinary bladder




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022853.15  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NMU gene promoter:
         LHX3b/Lhx3b   Nkx2-2   CUTL1   MEF-2A   S8   PPAR-gamma1   LHX3a/Lhx3a   PPAR-gamma2   aMEF-2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNMU promoter sequence
   Search SABiosciences Chromatin IP Primers for NMU

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

NMU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMU gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M056461:  view genomic region     (about GC identifiers)

Start:
56,461,396 bp from pter      End:
56,502,865 bp from pter
Size:
41,470 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NMU_HUMAN, P48645 (See protein sequence)
Recommended Name: Neuromedin-U precursor  
Size: 174 amino acids; 19741 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for NMU: NX_P48645

Explore proteomics data for NMU at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48645

  • NMU Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NMU Protein Expression
    REFSEQ proteins: NP_006672.1  
    ENSEMBL proteins: 
     ENSP00000422399   ENSP00000264218   ENSP00000424246   ENSP00000422870  
    Reactome Protein details: P48645
    Human Recombinant Protein Products for NMU: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for NMU
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NMU
    GenScript Custom Purified and Recombinant Proteins Services for NMU
    Novus Biologicals NMU Protein
    Novus Biologicals NMU Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NMU 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0043195terminal bouton IEA--

    NMU for ontologies           About GeneDecksing



    NMU Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals NMU Antibodies
    Abcam antibodies for NMU
    Cloud-Clone Corp. Antibodies for NMU 
    Search ThermoFisher Antibodies for NMU
    LSBio Antibodies in human, mouse, rat for NMU 

    Assay Products for NMU: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NMU
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NMU 
    Cloud-Clone Corp. CLIAs for NMU


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR018070 Neuromedin-U_amidation-site
     IPR008200 NMU_C

    Graphical View of Domain Structure for InterPro Entry P48645

    ProtoNet protein and cluster: P48645

    1 Blocks protein domain: IPB008199 Neuromedin U

    UniProtKB/Swiss-Prot: NMU_HUMAN, P48645
    Similarity: Belongs to the NmU family


    NMU for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMU_HUMAN, P48645
    Function: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU
    stimulates contractions of the ileum and urinary bladder

         Genatlas biochemistry entry for NMU:
    neuromedin U precursor containing potential proteolytic processing sites generating putative associated
    peptides,expressed in the gastrointestinal tract

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10811630
    GO:0042922neuromedin U receptor binding IEA--
         
    NMU for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nmu):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  immune system 
     liver/biliary system 

    NMU for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NMU: Nmutm1Mko Nmutm1Sjab

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NMU 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NMU

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NMU 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NMU 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMU
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NMU:
    hsa-miR-3065-5p hsa-miR-1305 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidNMU 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NMU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMU

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NMU
    Sirion Biotech Customized adenovirus for overexpression of NMU

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NMU (see all 6)
    OriGene ORF clones in mouse, rat for NMU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NMU (NM_006056)
    Sino Biological Human cDNA Clone for NMU
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMU
    Sirion Biotech Customized lentivirus for stable overexpression of NMU 
                         Customized lentivirus expression plasmids for stable overexpression of NMU 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NMU
    Search LifeMap BioReagents cell lines for NMU
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMU


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NMU About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NMU
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q



    5/9        Reactome Pathways for NMU (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    NMU for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NMU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/249 Interacting proteins for NMU (P486453 ENSP000002642184) via UniProtKB, MINT, STRING, and/or I2D (see all 249)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMUR2Q9GZQ43, ENSP000002552624I2D: score=4 STRING: ENSP00000255262
    NMUR1Q9HB893, ENSP000003058774I2D: score=4 STRING: ENSP00000305877
    KRTAP4-12Q9BQ663I2D: score=1 
    SNTA1Q134243I2D: score=1 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001696gastric acid secretion IEA--
    GO:0006940regulation of smooth muscle contraction TAS7619205
    GO:0006950response to stress IEA--
    GO:0007165signal transduction TAS7619205
    GO:0007186G-protein coupled receptor signaling pathway TAS10811630

    NMU for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NMU for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NMU

    4 Novoseek inferred chemical compound relationships for NMU gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 26 3 12399416 (1), 7683254 (1)
    corticosterone 15.2 2 12399416 (1)
    arginine 11.5 4 12399416 (1), 12177421 (1)
    calcium 9.62 4 15187020 (1), 10999960 (1), 11010960 (1)

    Search CenterWatch for drugs/clinical trials and news about NMU

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NMU gene: 
    NM_006681.2  

    Unigene Cluster for NMU:

    Neuromedin U
    Hs.418367  [show with all ESTs]
    Unigene Representative Sequence: BF034907
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511469(uc010igw.1) ENST00000264218(uc003hbc.3) ENST00000505262
    ENST00000507338(uc003hbd.1) ENST00000515325(uc010igv.1 uc010igx.1)
    ENST00000509371
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMU
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NMU:
    hsa-miR-3065-5p hsa-miR-1305 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidNMU 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NMU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMU
    Clone
    Products:
         
    OriGene clones in human, mouse for NMU (see all 6)
    OriGene ORF clones in mouse, rat for NMU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NMU (NM_006056)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMU
    Sirion Biotech Customized lentivirus for stable overexpression of NMU 
                         Customized lentivirus expression plasmids for stable overexpression of NMU 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NMU
    OriGene qSTAR qPCR primer pairs in human, mouse for NMU
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NMU
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMU
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMU

    Additional mRNA sequence: 

    AJ510133.1 AJ510134.1 AJ510135.1 AM279463.1 BC012908.1 X76029.1 

    5 DOTS entries:

    DT.407243  DT.100754178  DT.97837825  DT.86846750  DT.95156819 

    24/40 AceView cDNA sequences (see all 40):

    BQ049320 AW197091 BM767228 AA905581 AJ510133 AJ510134 BE743574 X76029 
    AI146565 AW167552 AJ510135 CA432938 AA912117 BF037322 NM_006681 BE747360 
    BF034907 BC012908 BF035464 BF037152 BF185217 BE735974 AI809647 BI603117 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NMU expression in normal human tissues (normalized intensities)      NMU embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGAAGAAT
    NMU Expression
    About this image


    NMU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             Olfactory Bulb   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Line H9 (WA09)
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells
             Fetal Liver CD36+ Cells   
     
     Ovary (Reproductive System)
             oocyte   
     
     Spinal Cord (Nervous System)
             Dorsal Horn   

    See NMU Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NMU

    SOURCE GeneReport for Unigene cluster: Hs.418367

    UniProtKB/Swiss-Prot: NMU_HUMAN, P48645
    Tissue specificity: Expressed throughout the enteric nervous system with highest levels being found in the jejunum

        SABiosciences Expression via Pathway-Focused PCR Array including NMU: 
              Obesity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMU
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NMU gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmu1 , 5 neuromedin U1, 5 79.84(n)1
    74.42(a)1
      5 (40.93 cM)5
    561831  NM_019515.11  NP_062388.11 
     763334955 
    chicken
    (Gallus gallus)
    Aves NMU1 neuromedin U 70.51(n)
    63.03(a)
      422748  XM_420701.3  XP_420701.1 
    lizard
    (Anolis carolinensis)
    Reptilia NMU6
    neuromedin U
    49(a)
    1 ↔ 1
    5(104844281-104887272)
    zebrafish
    (Danio rerio)
    Actinopterygii nmu6
    neuromedin U
    39(a)
    1 ↔ 1
    20(22117249-22134351)


    ENSEMBL Gene Tree for NMU (if available)
    TreeFam Gene Tree for NMU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NMU gene
    1 SIMAP similar gene for NMU using alignment to 8 protein entries:     NMU_HUMAN (see all proteins):
    NMS

    NMU for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/884 SNPs in NMU are shown (see all 884)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863278061,2
    --56460996(+) GGCAGA/GGCATG 1 -- int10--------
    rs19635661,2
    C--56461000(-) tcaccG/Atgccc 1 -- int112Minor allele frequency- A:0.03WA NA CSA EA 374
    rs1895542411,2
    --56461092(+) ACATGA/GTGAAA 1 -- int10--------
    rs1113949231,2
    C--56461159(+) GTGGCA/GCATGC 1 -- int10--------
    rs1136139891,2
    C--56461287(+) AAAAA-/ATGCAT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs20873191,2
    C,F,O,H--56461365(-) ACTGTG/TTAATA 1 -- int112Minor allele frequency- T:0.36NS EA NA 796
    rs350834241,2
    C--56461710(+) AGCTG-/TATA  
            
    TATAT
    1 -- int10--------
    rs2014003261,2
    --56461711(+) CTGTA-/TGTATAT 1 -- int10--------
    rs97594261,2
    C,A--56461730(+) ATATAC/TACACA 1 -- int10--------
    rs673110401,2
    C--56461731(+) ATATA-/ACAC/TAT
    ATATATACACA
    CACAC
    1 -- int11NA 2

    HapMap Linkage Disequilibrium report for NMU (56461396 - 56502865 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NMU:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658731CNV Deletion23128226
    esv2727637CNV Deletion23290073
    esv2675934CNV Deletion23128226
    esv2676033CNV Deletion23128226
    nsv879021CNV Loss21882294
    nsv10496CNV Loss18304495
    nsv509899CNV Loss20534489


    Human Gene Mutation Database (HGMD): NMU
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NMU
    DNA2.0 Custom Variant and Variant Library Synthesis for NMU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605103    OMIM disorders: --

    15 diseases for NMU:    About MalaCards
    seminal vesicle adenocarcinoma    eosinophilia    esophageal squamous cell carcinoma    obesity
    esophagitis    squamous cell carcinoma    pancreatic cancer    adenocarcinoma
    myeloid leukemia    pancreatitis    ovarian cancer    lung cancer
    thyroiditis    leukemia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NMU:
    Breast cancer

    NMU for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for NMU gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 30.1 10 16984985 (3), 19369576 (1), 16111886 (1), 19519756 (1) (see all 6)
    cancer 1.09 8 16878152 (3), 19118941 (2), 19645813 (1), 19519756 (1)
    inflammation 0 2 15585845 (1), 16373672 (1)
    tumors 0 9 16878152 (5), 19118941 (1)

    Genetic Association Database (GAD): NMU
    Human Genome Epidemiology (HuGE) Navigator: NMU (3 documents)

    Export disorders for NMU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NMU gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with NMU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract. (PubMed id 7619205)1, 2, 3, 9 Austin C.... Bloom S.R. (1995)
    2. Association between neuromedin U gene variants and overweight and obesity. (PubMed id 16984985)1, 4, 9 Hainerova I....Pedersen O. (2006)
    3. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PubMed id 22479202)1, 4 Dastani Z....Kathiresan S. (2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia. (PubMed id 16878152)1, 9 Wu Y....Theodorescu D. (2007)
    7. Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. (PubMed id 15187020)1, 9 Shetzline S.E....Gewirtz A.M. (2004)
    8. Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway. (PubMed id 19118941)1, 9 Ketterer K....Friess H. (2009)
    9. Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. (PubMed id 19519756)1, 9 Mitchell J.D....Davenport A.P. (2009)
    10. Characterization of neuromedin U effects in canine smooth muscle. (PubMed id 12023529)1, 9 Westfall T.D....Hieble J.P. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10874 HGNC: 7859 AceView: NMU Ensembl:ENSG00000109255 euGenes: HUgn10874
    ECgene: NMU H-InvDB: NMU

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NMU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NMU gene:
    Search GeneIP for patents involving NMU

    GeneCards and IP:
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