Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NMU Gene

Aliases for NMU Gene

  • Neuromedin U 2 3 5
  • Prepro-NMU 2 3
  • Neuromedin-U 3

External Ids for NMU Gene

Previous GeneCards Identifiers for NMU Gene

  • GC04M056265
  • GC04M056422
  • GC04M056311
  • GC04M056376
  • GC04M056302
  • GC04M056156
  • GC04M056461
  • GC04M052410

Summaries for NMU Gene

Entrez Gene Summary for NMU Gene

  • This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

GeneCards Summary for NMU Gene

NMU (Neuromedin U) is a Protein Coding gene. Diseases associated with NMU include Trachea Leiomyoma and Squamous Cell Papilloma. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include receptor binding and neuromedin U receptor binding.

UniProtKB/Swiss-Prot for NMU Gene

  • Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMU Gene

Genomics for NMU Gene

Regulatory Elements for NMU Gene

Enhancers for NMU Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G055637 0.9 ENCODE 20.4 -1.0 -1036 1.4 HDAC1 TBL1XR1 NFRKB ZBTB40 RAD21 EGR1 CREM SMAD5 ELF4 REST NMU TMEM165 LOC105377660
GH04G055611 0.6 ENCODE 28.7 +24.4 24390 0.9 POLR2H PAF1 JUN CREB1 NFE2 ATF2 NMU TMEM165 SRD5A3 PDCL2
GH04G055608 0.6 ENCODE 28.7 +26.7 26698 3.2 PAF1 KLF1 TAL1 DPF2 POLR2H TCF12 ARID1B ZNF766 KDM1A NMU TMEM165 KDR SRD5A3 PDCL2
GH04G055548 0.8 ENCODE 20.4 +86.7 86662 2.3 ZNF146 INSM2 FEZF1 FOSL1 ZNF664 HIC1 ZNF121 GLI2 ZSCAN5C SCRT2 TMEM165 NMU CLOCK ENSG00000272969 SRD5A3-AS1 PDCL2
GH04G055394 1.4 ENCODE dbSUPER 9.9 +239.4 239408 4.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 CEP135 TMEM165 RN7SKP30 CLOCK AASDH SRD5A3 NMU ENSG00000272969 GC04P055398
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NMU on UCSC Golden Path with GeneCards custom track

Genomic Location for NMU Gene

55,595,229 bp from pter
55,636,698 bp from pter
41,470 bases
Minus strand

Genomic View for NMU Gene

Genes around NMU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMU Gene

Proteins for NMU Gene

  • Protein details for NMU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for NMU Gene

    174 amino acids
    Molecular mass:
    19741 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMU Gene

Post-translational modifications for NMU Gene

  • Glycosylation at Ser109
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NMU Gene

Domains & Families for NMU Gene

Gene Families for NMU Gene

Protein Domains for NMU Gene

Suggested Antigen Peptide Sequences for NMU Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NmU family.
  • Belongs to the NmU family.
genes like me logo Genes that share domains with NMU: view

Function for NMU Gene

Molecular function for NMU Gene

GENATLAS Biochemistry:
neuromedin U precursor containing potential proteolytic processing sites generating putative associated peptides,expressed in the gastrointestinal tract
UniProtKB/Swiss-Prot Function:
Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.

Gene Ontology (GO) - Molecular Function for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10811630
GO:0005515 protein binding IPI 25416956
GO:0042922 neuromedin U receptor binding IEA --
genes like me logo Genes that share ontologies with NMU: view
genes like me logo Genes that share phenotypes with NMU: view

Animal Models for NMU Gene

MGI Knock Outs for NMU:

Animal Model Products

  • Taconic Biosciences Mouse Models for NMU

CRISPR Products

miRNA for NMU Gene

miRTarBase miRNAs that target NMU

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NMU

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMU Gene

Localization for NMU Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMU Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMU gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0043195 terminal bouton IEA --
genes like me logo Genes that share ontologies with NMU: view

Pathways & Interactions for NMU Gene

genes like me logo Genes that share pathways with NMU: view

Gene Ontology (GO) - Biological Process for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001696 gastric acid secretion IEA --
GO:0006940 regulation of smooth muscle contraction IEA,TAS 7619205
GO:0007165 signal transduction TAS 7619205
GO:0007186 G-protein coupled receptor signaling pathway TAS 10811630
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NMU: view

No data available for SIGNOR curated interactions for NMU Gene

Drugs & Compounds for NMU Gene

(4) Drugs for NMU Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NMU: view

Transcripts for NMU Gene

Unigene Clusters for NMU Gene

Neuromedin U:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NMU

Alternative Splicing Database (ASD) splice patterns (SP) for NMU Gene

No ASD Table

Relevant External Links for NMU Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NMU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMU Gene

mRNA differential expression in normal tissues according to GTEx for NMU Gene

This gene is overexpressed in Esophagus - Mucosa (x22.6), Vagina (x6.4), Skin - Sun Exposed (Lower leg) (x5.9), and Skin - Not Sun Exposed (Suprapubic) (x5.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NMU Gene

NURSA nuclear receptor signaling pathways regulating expression of NMU Gene:


SOURCE GeneReport for Unigene cluster for NMU Gene:


mRNA Expression by UniProt/SwissProt for NMU Gene:

Tissue specificity: Expressed throughout the enteric nervous system with highest levels being found in the jejunum.

Evidence on tissue expression from TISSUES for NMU Gene

  • Nervous system(4.5)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with NMU: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMU Gene

Orthologs for NMU Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMU Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NMU 34 35
  • 99.62 (n)
(Bos Taurus)
Mammalia NMU 34 35
  • 85.93 (n)
(Canis familiaris)
Mammalia NMU 34
  • 85.27 (n)
(Mus musculus)
Mammalia Nmu 34 16 35
  • 79.84 (n)
(Rattus norvegicus)
Mammalia Nmu 34
  • 78.88 (n)
(Ornithorhynchus anatinus)
Mammalia NMU 35
  • 61 (a)
(Monodelphis domestica)
Mammalia NMU 35
  • 40 (a)
(Gallus gallus)
Aves NMU 34 35
  • 70.51 (n)
(Anolis carolinensis)
Reptilia NMU 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nmu 34
  • 66.37 (n)
(Danio rerio)
Actinopterygii nmu 34 35
  • 56.39 (n)
Species where no ortholog for NMU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMU Gene

Gene Tree for NMU (if available)
Gene Tree for NMU (if available)

Paralogs for NMU Gene

(1) SIMAP similar genes for NMU Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with NMU: view

No data available for Paralogs for NMU Gene

Variants for NMU Gene

Sequence variations from dbSNP and Humsavar for NMU Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000042498 -- 55,608,438(+) TATTA(C/T)ATATG intron-variant
rs10000512 -- 55,602,855(+) ACTGG(A/C)CATAA intron-variant
rs10000850 -- 55,634,211(+) GTGCC(A/T)TCTTT intron-variant
rs1000142990 -- 55,601,201(+) CATTT(A/C)ATTTT intron-variant
rs1000283026 -- 55,633,257(+) GAGGC(A/G)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMU Gene

Variant ID Type Subtype PubMed ID
dgv1482e212 CNV loss 25503493
esv2658731 CNV deletion 23128226
esv2675934 CNV deletion 23128226
esv2676033 CNV deletion 23128226
esv2727637 CNV deletion 23290073
esv2762435 CNV loss 21179565
esv3600554 CNV loss 21293372
esv3600555 CNV loss 21293372
esv3600559 CNV loss 21293372
nsv10496 CNV loss 18304495
nsv509899 OTHER sequence alteration 20534489

Variation tolerance for NMU Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMU Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMU Gene

Disorders for NMU Gene

MalaCards: The human disease database

(4) MalaCards diseases for NMU Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
trachea leiomyoma
  • tracheal neoplasm
squamous cell papilloma
  • epidermoid papilloma
seminal vesicle adenocarcinoma
miles-carpenter syndrome
  • miles-carpenter x-linked mental retardation syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NMU in MalaCards View complete list of genes associated with diseases

Relevant External Links for NMU

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NMU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMU Gene

Publications for NMU Gene

  1. Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract. (PMID: 7619205) Austin C. … Bloom S.R. (J. Mol. Endocrinol. 1995) 2 3 4 22 64
  2. Association between neuromedin U gene variants and overweight and obesity. (PMID: 16984985) HainerovA! I. … Pedersen O. (J. Clin. Endocrinol. Metab. 2006) 3 22 46 64
  3. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z. … Kathiresan S. (PLoS Genet. 2012) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway. (PMID: 19118941) Ketterer K. … Friess H. (Cancer Lett. 2009) 3 22 64

Products for NMU Gene

Sources for NMU Gene

Loading form....