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Aliases for NMU Gene

Aliases for NMU Gene

  • Neuromedin U 2 3
  • Prepro-NMU 2 3

External Ids for NMU Gene

Previous GeneCards Identifiers for NMU Gene

  • GC04M056265
  • GC04M056422
  • GC04M056311
  • GC04M056376
  • GC04M056302
  • GC04M056156
  • GC04M056461
  • GC04M052410

Summaries for NMU Gene

Entrez Gene Summary for NMU Gene

  • This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

GeneCards Summary for NMU Gene

NMU (Neuromedin U) is a Protein Coding gene. Diseases associated with NMU include squamous cell papilloma and trachea leiomyoma. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor binding and neuromedin U receptor binding.

UniProtKB/Swiss-Prot for NMU Gene

  • Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMU Gene

Genomics for NMU Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NMU Gene

Chromosome:
4
Start:
55,595,229 bp from pter
End:
55,636,698 bp from pter
Size:
41,470 bases
Orientation:
Minus strand

Genomic View for NMU Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMU Gene

Proteins for NMU Gene

  • Protein details for NMU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48645-NMU_HUMAN
    Recommended name:
    Neuromedin-U
    Protein Accession:
    P48645

    Protein attributes for NMU Gene

    Size:
    174 amino acids
    Molecular mass:
    19741 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMU Gene

Proteomics data for NMU Gene at MOPED

Post-translational modifications for NMU Gene

  • Glycosylation at Ser 109
  • Modification sites at PhosphoSitePlus

Other Protein References for NMU Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NMU

No data available for DME Specific Peptides for NMU Gene

Domains & Families for NMU Gene

Gene Families for NMU Gene

Protein Domains for NMU Gene

Suggested Antigen Peptide Sequences for NMU Gene

Graphical View of Domain Structure for InterPro Entry

P48645

UniProtKB/Swiss-Prot:

NMU_HUMAN :
  • Belongs to the NmU family.
Family:
  • Belongs to the NmU family.
genes like me logo Genes that share domains with NMU: view

Function for NMU Gene

Molecular function for NMU Gene

GENATLAS Biochemistry:
neuromedin U precursor containing potential proteolytic processing sites generating putative associated peptides,expressed in the gastrointestinal tract
UniProtKB/Swiss-Prot Function:
Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder

Gene Ontology (GO) - Molecular Function for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10811630
GO:0005515 protein binding IPI 25416956
GO:0042922 neuromedin U receptor binding IEA --
genes like me logo Genes that share ontologies with NMU: view
genes like me logo Genes that share phenotypes with NMU: view

Animal Models for NMU Gene

MGI Knock Outs for NMU:

Animal Model Products

miRNA for NMU Gene

miRTarBase miRNAs that target NMU

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMU

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NMU Gene

Localization for NMU Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMU Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMU Gene COMPARTMENTS Subcellular localization image for NMU gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0043195 terminal bouton IEA --
genes like me logo Genes that share ontologies with NMU: view

Pathways & Interactions for NMU Gene

genes like me logo Genes that share pathways with NMU: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001696 gastric acid secretion IEA --
GO:0006940 regulation of smooth muscle contraction TAS 7619205
GO:0007165 signal transduction TAS 7619205
GO:0007186 G-protein coupled receptor signaling pathway TAS 10811630
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NMU: view

No data available for SIGNOR curated interactions for NMU Gene

Drugs & Compounds for NMU Gene

(4) Drugs for NMU Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ACTH Pharma 0
Corticosterone Pharma Endogenous glucocorticoid 9
arginine Nutra 346
Calcium Nutra 0
genes like me logo Genes that share compounds with NMU: view

Transcripts for NMU Gene

Unigene Clusters for NMU Gene

Neuromedin U:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMU

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMU Gene

No ASD Table

Relevant External Links for NMU Gene

GeneLoc Exon Structure for
NMU
ECgene alternative splicing isoforms for
NMU

Expression for NMU Gene

mRNA expression in normal human tissues for NMU Gene

mRNA differential expression in normal tissues according to GTEx for NMU Gene

This gene is overexpressed in Esophagus - Mucosa (x22.6), Vagina (x6.4), Skin - Sun Exposed (Lower leg) (x5.9), and Skin - Not Sun Exposed (Suprapubic) (x5.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMU Gene



SOURCE GeneReport for Unigene cluster for NMU Gene Hs.418367

mRNA Expression by UniProt/SwissProt for NMU Gene

P48645-NMU_HUMAN
Tissue specificity: Expressed throughout the enteric nervous system with highest levels being found in the jejunum
genes like me logo Genes that share expression patterns with NMU: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for NMU Gene

Orthologs for NMU Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMU Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NMU 35
  • 85.93 (n)
  • 78.61 (a)
NMU 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMU 35
  • 85.27 (n)
  • 81.16 (a)
mouse
(Mus musculus)
Mammalia Nmu 35
  • 79.84 (n)
  • 74.42 (a)
Nmu 16
Nmu 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NMU 35
  • 99.62 (n)
  • 99.43 (a)
NMU 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmu 35
  • 78.88 (n)
  • 72.09 (a)
oppossum
(Monodelphis domestica)
Mammalia NMU 36
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMU 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMU 35
  • 70.51 (n)
  • 63.03 (a)
NMU 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMU 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmu 35
  • 66.37 (n)
  • 62.16 (a)
zebrafish
(Danio rerio)
Actinopterygii nmu 35
  • 56.39 (n)
  • 48.87 (a)
nmu 36
  • 40 (a)
OneToOne
Species with no ortholog for NMU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMU Gene

ENSEMBL:
Gene Tree for NMU (if available)
TreeFam:
Gene Tree for NMU (if available)

Paralogs for NMU Gene

(1) SIMAP similar genes for NMU Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with NMU: view

No data available for Paralogs for NMU Gene

Variants for NMU Gene

Sequence variations from dbSNP and Humsavar for NMU Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_053538 -
VAR_053539 -

Structural Variations from Database of Genomic Variants (DGV) for NMU Gene

Variant ID Type Subtype PubMed ID
nsv10496 CNV Loss 18304495
esv2675934 CNV Deletion 23128226
esv2676033 CNV Deletion 23128226
nsv509899 CNV Loss 20534489
esv2727637 CNV Deletion 23290073
nsv879021 CNV Loss 21882294
esv2658731 CNV Deletion 23128226

Variation tolerance for NMU Gene

Residual Variation Intolerance Score: 75.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMU Gene

HapMap Linkage Disequilibrium report
NMU
Human Gene Mutation Database (HGMD)
NMU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMU Gene

Disorders for NMU Gene

MalaCards: The human disease database

(3) MalaCards diseases for NMU Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
squamous cell papilloma
  • epidermoid papilloma
trachea leiomyoma
  • neoplasm of trachea
obesity
  • obesity, association with
- elite association
Search NMU in MalaCards View complete list of genes associated with diseases

Relevant External Links for NMU

Genetic Association Database (GAD)
NMU
Human Genome Epidemiology (HuGE) Navigator
NMU
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMU
genes like me logo Genes that share disorders with NMU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMU Gene

Publications for NMU Gene

  1. Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract. (PMID: 7619205) Austin C. … Bloom S.R. (J. Mol. Endocrinol. 1995) 2 23 67
  2. Genome-wide census and expression profiling of chicken neuropeptide and prohormone convertase genes. (PMID: 20006904) Delfino K.R. … Rodriguez-Zas S.L. (Neuropeptides 2010) 23 67
  3. Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway. (PMID: 19118941) Ketterer K. … Friess H. (Cancer Lett. 2009) 23 67
  4. Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2. (PMID: 19369576) Liu J.J. … Bostwick J.R. (J. Pharmacol. Exp. Ther. 2009) 23 67
  5. Appetite-modifying actions of pro-neuromedin U-derived peptides. (PMID: 19531638) Bechtold D.A. … Luckman S.M. (Am. J. Physiol. Endocrinol. Metab. 2009) 23 67

Products for NMU Gene

Sources for NMU Gene

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