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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NMU Gene

protein-coding   GIFtS: 54
GCID: GC04M056461

neuromedin U
 Explore 16 diseases affiliated with
NMU via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NMU    

Aliases
for NMU gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neuromedin U1 2
Neuromedin-U1

External Ids:    HGNC: 78591   Entrez Gene: 108742   Ensembl: ENSG000001092557   OMIM: 6051035   UniProtKB: P486453   

Export aliases for NMU gene to outside databases

Previous GC identifers: GC04M056265 GC04M056422 GC04M056311 GC04M056376 GC04M056302 GC04M056156 GC04M052410


Summaries
for NMU gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NMU_HUMAN, P48645
Function: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates
contractions of the ileum and urinary bladder




Genomic Views
for NMU gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022853.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NMU gene promoter:
         LHX3b/Lhx3b   Nkx2-2   CUTL1   MEF-2A   S8   PPAR-gamma1   LHX3a/Lhx3a   PPAR-gamma2   aMEF-2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NMU promoter sequence
   Search SABiosciences Chromatin IP Primers for NMU

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

NMU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMU gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M056461:  view genomic region     (about GC identifiers)

Start:
 56,461,396 bp from pter      End:
 56,502,865 bp from pter
Size:
 41,470 bases      Orientation:
 minus strand

Proteins
for NMU gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NMU_HUMAN, P48645 (See protein sequence)
Recommended Name: Neuromedin-U precursor  
Size: 174 amino acids; 19741 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for NMU: NX_P48645

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48645

    • NMU Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006672.1  
    ENSEMBL proteins: 
     ENSP00000422399   ENSP00000264218   ENSP00000424246   ENSP00000422870  
    Reactome Protein details: P48645
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: NMU
    OriGene Custom Protein Services for NMU 
    GenScript Custom Purified and Recombinant Proteins Services for NMU
    Novus Biologicals NMU Protein
    Novus Biologicals NMU Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NMU

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0043195terminal bouton IEA--


    NMU for ontologies           About GeneDecksing



    NMU Antibody Products: 
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    Uscn Antibodies for NMU
    Search ThermoFisher Antibodies for NMU

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    Uscn ELISAs and CLIAs for NMU

    Protein Domains /
    Families
    for NMU gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NMU for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018070 Neuromedin-U_amidation-site
     IPR008200 NMU_C

    Graphical View of Domain Structure for InterPro Entry P48645

    ProtoNet protein and cluster: P48645

    1 Blocks protein family: IPB008199 Neuromedin U

    UniProtKB/Swiss-Prot: NMU_HUMAN, P48645
    Similarity: Belongs to the NmU family


    Function
    for NMU gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NMU_HUMAN, P48645
    Function: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates
    contractions of the ileum and urinary bladder

         Genatlas biochemistry entry for NMU:
    neuromedin U precursor containing potential proteolytic processing sites generating putative associated
    peptides,expressed in the gastrointestinal tract

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMU
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NMU:
    hsa-miR-3065-5p hsa-miR-1305 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: NMU 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NMU (see all 7)
    OriGene shRNA RFP: NMU
    OriGene siRNA: NMU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMU

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NMU

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NMU (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMU 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NMU
    Search LifeMap BioReagents cell lines for NMU

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NMU

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10811630
    GO:0042922neuromedin U receptor binding IEA--


    NMU for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NMU: Nmutm1Mko Nmutm1Sjab
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nmu):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  immune system 
     liver/biliary system 

    NMU for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NMU gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    		G alpha (i) signalling events0.44
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3G alpha (q) signalling events
    		G alpha (q) signalling events1.00
    		Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NMU
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    5/9        Reactome Pathways for NMU (see all 9)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    NMU for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NMU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/249 Interacting proteins for NMU (P486453 ENSP000002642184) via UniProtKB, MINT, STRING, and/or I2D (see all 249)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMUR2Q9GZQ43, ENSP000002552624I2D: score=4 STRING: ENSP00000255262
    NMUR1Q9HB893, ENSP000003058774I2D: score=4 STRING: ENSP00000305877
    KRTAP4-12Q9BQ663I2D: score=1 
    SNTA1Q134243I2D: score=1 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001696gastric acid secretion IEA--
    GO:0006940regulation of smooth muscle contraction TAS7619205
    GO:0006950response to stress IEA--
    GO:0007165signal transduction TAS7619205
    GO:0007186G-protein coupled receptor signaling pathway TAS10811630


    NMU for ontologies           About GeneDecksing



    Drugs & Compounds
    for NMU gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NMU for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NMU
    4 Novoseek chemical compound relationships for NMU gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acth 26 3 12399416 (1), 7683254 (1)
    corticosterone 15.2 2 12399416 (1)
    arginine 11.5 4 12399416 (1), 12177421 (1)
    calcium 9.62 4 15187020 (1), 10999960 (1), 11010960 (1)

    Search CenterWatch for drugs/clinical trials and news about NMU 

    Transcripts
    for NMU gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NMU gene: 
    NM_006681.2  

    Unigene Cluster for NMU:

    Neuromedin U
    Hs.418367  [show with all ESTs]
    Unigene Representative Sequence: BF034907
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511469(uc010igw.1) ENST00000264218(uc003hbc.3) ENST00000505262
    ENST00000507338(uc003hbd.1) ENST00000515325(uc010igv.1 uc010igx.1)
    ENST00000509371

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMU
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NMU:
    hsa-miR-3065-5p hsa-miR-1305 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: NMU 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NMU (see all 7)
    OriGene shRNA RFP: NMU
    OriGene siRNA: NMU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMU
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NMU (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NMU
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NMU (NM_006056)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMU 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMU

    Additional cDNA sequence: 

    AJ510133.1 AJ510134.1 AJ510135.1 AM279463.1 BC012908.1 X76029.1 

    5 DOTS entries:

    DT.407243  DT.100754178  DT.97837825  DT.86846750  DT.95156819 

    24/40 AceView cDNA sequences (see all 40):

    BM767228 AW197091 AA905581 BQ049320 X76029 CA432938 BE743574 AA912117 
    BC012908 BE747360 AJ510133 AJ510134 AI146565 AW167552 BF034907 BF037322 
    AJ510135 NM_006681 BE735974 BF035464 BF037152 BI603117 AA074391 AI809647 

    GeneLoc Exon Structure


    Expression
    for NMU gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NMU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAGAAGAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NMU expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mesendoderm-like cells (Generation of mesend...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Alveolar type II cells (Derivation of mature...)Lung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NMU Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NMU

    SOURCE GeneReport for Unigene cluster: Hs.418367

    UniProtKB/Swiss-Prot: NMU_HUMAN, P48645
    Tissue specificity: Expressed throughout the enteric nervous system with highest levels being found in the jejunum

        SABiosciences Expression via Pathway-Focused PCR Array including NMU: 
              Obesity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NMU

    Orthologs
    for NMU gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NMU gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nmu1 , 5 neuromedin U1, 5 79.84(n)1
    74.42(a)1    		   5 (40.93 cM)5
    561831  NM_019515.11  NP_062388.11 
     763334955 
    chicken
    (Gallus gallus)    		 Aves NMU1 neuromedin U 70.51(n)
    63.03(a)    		   422748  XM_420701.3  XP_420701.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nmu6
    		 neuromedin U
    		 41(a)
    		 1 ↔ 1
    		 20(22117337-22134327)


    ENSEMBL Gene Tree for NMU (if available)
    TreeFam Gene Tree for NMU (if available) 

    Paralogs
    for NMU gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NMU gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): NMU
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NMU
    DNA2.0 Custom Variant and Variant Library Synthesis for NMU

    Disorders / Diseases
    for NMU gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NMU for disorders           About GeneDecksing

    OMIM gene information: 605103    OMIM disorders: --

    16 diseases for NMU:    About MalaCards
    seminal vesicle adenocarcinoma    esophageal squamous cell carcinoma    squamous cell carcinoma    eosinophilia
    myeloid leukemia    obesity    esophagitis    ovarian cancer
    pancreatic cancer    lung cancer    pancreatitis    carcinoma
    leukemia    thyroiditis    adenocarcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NMU:
    Breast cancer

    4 Novoseek disease relationships for NMU gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 30.1 10 16984985 (3), 19369576 (1), 16111886 (1), 19519756 (1) (see all 6)
    cancer 1.09 8 16878152 (3), 19118941 (2), 19645813 (1), 19519756 (1)
    inflammation 0 2 15585845 (1), 16373672 (1)
    tumors 0 9 16878152 (5), 19118941 (1)

    Human Genome Epidemiology (HuGE) Navigator: NMU (3 documents)

    Export disorders for NMU gene to outside databases

    Publications
    for NMU gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NMU gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with NMU)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract. (PubMed id 7619205)1, 2, 3, 9 Austin C.... Bloom S.R. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia. (PubMed id 16878152)1, 9 Wu Y....Theodorescu D. (2007)
    4. Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. (PubMed id 15187020)1, 9 Shetzline S.E....Gewirtz A.M. (2004)
    5. Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway. (PubMed id 19118941)1, 9 Ketterer K....Friess H. (2009)
    6. Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. (PubMed id 19519756)1, 9 Mitchell J.D....Davenport A.P. (2009)
    7. Characterization of neuromedin U effects in canine smooth muscle. (PubMed id 12023529)1, 9 Westfall T.D....Hieble J.P. (2002)
    8. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. (PubMed id 10783389)1, 9 Fujii R....Fujino M. (2000)
    9. Association between neuromedin U gene variants and overweight and obesity. (PubMed id 16984985)1, 9 Hainerova I....Pedersen O. (2006)
    10. Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U. (PubMed id 10999960)1, 9 Hedrick J.A....Monsma F.J. (2000)

    External Searches for NMU gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing NMU gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10874 HGNC: 7859 AceView: NMU Ensembl:ENSG00000109255 euGenes: HUgn10874
    ECgene: NMU H-InvDB: NMU

    Other Databases showing NMU gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NMU gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NMU Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NMU gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NMU gene:
    Search GeneIP for patents involving NMU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
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     NMU Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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