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Aliases for NMU Gene

Aliases for NMU Gene

  • Neuromedin U 2 3 5
  • Prepro-NMU 2 3
  • Neuromedin-U 3

External Ids for NMU Gene

Previous GeneCards Identifiers for NMU Gene

  • GC04M056265
  • GC04M056422
  • GC04M056311
  • GC04M056376
  • GC04M056302
  • GC04M056156
  • GC04M056461
  • GC04M052410

Summaries for NMU Gene

Entrez Gene Summary for NMU Gene

  • This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

GeneCards Summary for NMU Gene

NMU (Neuromedin U) is a Protein Coding gene. Diseases associated with NMU include Squamous Cell Papilloma and Seminal Vesicle Adenocarcinoma. Among its related pathways are Signaling by GPCR and RET signaling. GO annotations related to this gene include receptor binding and neuromedin U receptor binding.

UniProtKB/Swiss-Prot for NMU Gene

  • Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.

Additional gene information for NMU Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMU Gene

Genomics for NMU Gene

Regulatory Elements for NMU Gene

Enhancers for NMU Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H055548 0.8 ENCODE 20.5 +86.7 86662 2.3 ZNF146 INSM2 FEZF1 FOSL1 ZNF664 HIC1 ZNF121 GLI2 ZSCAN5C SCRT2 TMEM165 NMU CLOCK ENSG00000272969 SRD5A3-AS1 PDCL2
GH04H055637 0.8 ENCODE 20.4 -1.0 -1036 1.4 TBP TBL1XR1 NFRKB ZBTB40 RAD21 EGR1 ATF7 CREM SMAD5 REST NMU CLOCK AASDH ENSG00000269921 TMEM165 LOC105377660
GH04H055611 0.5 ENCODE 28.7 +24.4 24390 0.9 JUN CREB1 NFE2 ATF2 NMU TMEM165 SRD5A3 PDCL2
GH04H055394 1.4 ENCODE dbSUPER 9.9 +239.4 239408 4.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 CEP135 TMEM165 RN7SKP30 CLOCK AASDH SRD5A3 NMU ENSG00000272969 GC04P055398
GH04H055386 1.3 ENCODE dbSUPER 9.1 +249.5 249458 2.2 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ZNF143 ATF7 NFYC TMEM165 ENSG00000272969 NMU SRD5A3-AS1 ENSG00000273257 LOC105377659
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NMU on UCSC Golden Path with GeneCards custom track

Genomic Locations for NMU Gene

Genomic Locations for NMU Gene
chr4:55,595,229-55,636,698
(GRCh38/hg38)
Size:
41,470 bases
Orientation:
Minus strand
chr4:56,461,396-56,502,865
(GRCh37/hg19)

Genomic View for NMU Gene

Genes around NMU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMU Gene

Proteins for NMU Gene

  • Protein details for NMU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48645-NMU_HUMAN
    Recommended name:
    Neuromedin-U
    Protein Accession:
    P48645

    Protein attributes for NMU Gene

    Size:
    174 amino acids
    Molecular mass:
    19741 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMU Gene

Post-translational modifications for NMU Gene

  • Glycosylation at Ser109
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NMU Gene

Domains & Families for NMU Gene

Gene Families for NMU Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NMU Gene

Suggested Antigen Peptide Sequences for NMU Gene

Graphical View of Domain Structure for InterPro Entry

P48645

UniProtKB/Swiss-Prot:

NMU_HUMAN :
  • Belongs to the NmU family.
Family:
  • Belongs to the NmU family.
genes like me logo Genes that share domains with NMU: view

Function for NMU Gene

Molecular function for NMU Gene

GENATLAS Biochemistry:
neuromedin U precursor containing potential proteolytic processing sites generating putative associated peptides,expressed in the gastrointestinal tract
UniProtKB/Swiss-Prot Function:
Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.

Phenotypes From GWAS Catalog for NMU Gene

Gene Ontology (GO) - Molecular Function for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10811630
GO:0005515 protein binding IPI 25416956
GO:0042922 neuromedin U receptor binding IEA --
genes like me logo Genes that share ontologies with NMU: view
genes like me logo Genes that share phenotypes with NMU: view

Animal Models for NMU Gene

MGI Knock Outs for NMU:

miRNA for NMU Gene

miRTarBase miRNAs that target NMU

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMU Gene

Localization for NMU Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMU Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMU gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0043195 terminal bouton IEA --
genes like me logo Genes that share ontologies with NMU: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NMU Gene

Pathways & Interactions for NMU Gene

genes like me logo Genes that share pathways with NMU: view

Gene Ontology (GO) - Biological Process for NMU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001696 gastric acid secretion IEA --
GO:0006940 regulation of smooth muscle contraction TAS,IEA 7619205
GO:0007165 signal transduction TAS 7619205
GO:0007186 G-protein coupled receptor signaling pathway TAS 10811630
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NMU: view

No data available for SIGNOR curated interactions for NMU Gene

Drugs & Compounds for NMU Gene

(4) Drugs for NMU Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NMU: view

Transcripts for NMU Gene

Unigene Clusters for NMU Gene

Neuromedin U:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMU Gene

No ASD Table

Relevant External Links for NMU Gene

GeneLoc Exon Structure for
NMU
ECgene alternative splicing isoforms for
NMU

Expression for NMU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMU Gene

mRNA differential expression in normal tissues according to GTEx for NMU Gene

This gene is overexpressed in Esophagus - Mucosa (x22.6), Vagina (x6.4), Skin - Sun Exposed (Lower leg) (x5.9), and Skin - Not Sun Exposed (Suprapubic) (x5.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NMU Gene



NURSA nuclear receptor signaling pathways regulating expression of NMU Gene:

NMU

SOURCE GeneReport for Unigene cluster for NMU Gene:

Hs.418367

mRNA Expression by UniProt/SwissProt for NMU Gene:

P48645-NMU_HUMAN
Tissue specificity: Expressed throughout the enteric nervous system with highest levels being found in the jejunum.

Evidence on tissue expression from TISSUES for NMU Gene

  • Nervous system(4.5)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with NMU: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMU Gene

Orthologs for NMU Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMU 33 34
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia NMU 33 34
  • 85.93 (n)
dog
(Canis familiaris)
Mammalia NMU 33
  • 85.27 (n)
mouse
(Mus musculus)
Mammalia Nmu 33 16 34
  • 79.84 (n)
rat
(Rattus norvegicus)
Mammalia Nmu 33
  • 78.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NMU 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMU 34
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMU 33 34
  • 70.51 (n)
lizard
(Anolis carolinensis)
Reptilia NMU 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmu 33
  • 66.37 (n)
zebrafish
(Danio rerio)
Actinopterygii nmu 33 34
  • 56.39 (n)
Species where no ortholog for NMU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMU Gene

ENSEMBL:
Gene Tree for NMU (if available)
TreeFam:
Gene Tree for NMU (if available)

Paralogs for NMU Gene

(1) SIMAP similar genes for NMU Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with NMU: view

No data available for Paralogs for NMU Gene

Variants for NMU Gene

Sequence variations from dbSNP and Humsavar for NMU Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000042498 -- 55,608,438(+) TATTA(C/T)ATATG intron-variant
rs10000512 -- 55,602,855(+) ACTGG(A/C)CATAA intron-variant
rs10000850 -- 55,634,211(+) GTGCC(A/T)TCTTT intron-variant
rs1000142990 -- 55,601,201(+) CATTT(A/C)ATTTT intron-variant
rs1000283026 -- 55,633,257(+) GAGGC(A/G)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMU Gene

Variant ID Type Subtype PubMed ID
nsv509899 OTHER sequence alteration 20534489
nsv10496 CNV loss 18304495
esv3600559 CNV loss 21293372
esv3600555 CNV loss 21293372
esv3600554 CNV loss 21293372
esv2762435 CNV loss 21179565
esv2727637 CNV deletion 23290073
esv2676033 CNV deletion 23128226
esv2675934 CNV deletion 23128226
esv2658731 CNV deletion 23128226
dgv1482e212 CNV loss 25503493

Variation tolerance for NMU Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMU Gene

Human Gene Mutation Database (HGMD)
NMU
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMU Gene

Disorders for NMU Gene

MalaCards: The human disease database

(4) MalaCards diseases for NMU Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
squamous cell papilloma
  • epidermoid papilloma
seminal vesicle adenocarcinoma
trachea leiomyoma
  • tracheal neoplasm
miles-carpenter syndrome
  • mcs
- elite association - COSMIC cancer census association via MalaCards
Search NMU in MalaCards View complete list of genes associated with diseases

Relevant External Links for NMU

Genetic Association Database (GAD)
NMU
Human Genome Epidemiology (HuGE) Navigator
NMU
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMU
genes like me logo Genes that share disorders with NMU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMU Gene

Publications for NMU Gene

  1. Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract. (PMID: 7619205) Austin C … Bloom SR (Journal of molecular endocrinology 1995) 2 3 4 22 60
  2. Association between neuromedin U gene variants and overweight and obesity. (PMID: 16984985) Hainerová I … Pedersen O (The Journal of clinical endocrinology and metabolism 2006) 3 22 45 60
  3. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z … Kathiresan S (PLoS genetics 2012) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. (PMID: 19519756) Mitchell JD … Davenport AP (British journal of pharmacology 2009) 3 22 60

Products for NMU Gene

Sources for NMU Gene

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