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NMT2 Gene

protein-coding   GIFtS: 62
GCID: GC10M015144

N-Myristoyltransferase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Myristoyltransferase 21 2     NMT 22 3
Myristoyl-CoA:Protein N-Myristoyltransferase 22 3     EC 2.3.1.973 8
Peptide N-Myristoyltransferase 22 3     Glycylpeptide N-Tetradecanoyltransferase 22
Type II N-Myristoyltransferase2 3     Glycylpeptide N-Tetradecanoyltransferase 2 Variant 32

External Ids:    HGNC: 78581   Entrez Gene: 93972   Ensembl: ENSG000001524657   OMIM: 6038015   UniProtKB: O605513   

Export aliases for NMT2 gene to outside databases

Previous GC identifers: GC10M015132 GC10M015300 GC10M015153 GC10M015189 GC10M015172 GC10M015060


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NMT2 Gene:
N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It
transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue.
Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and
/or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence
identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NMT2 Gene:
NMT2 (N-myristoyltransferase 2) is a protein-coding gene. Diseases associated with NMT2 include impotence, and hiv-1. GO annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity. An important paralog of this gene is NMT1.

UniProtKB/Swiss-Prot: NMT2_HUMAN, O60551
Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins

Gene Wiki entry for NMT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NMT2 gene promoter:
         SRF   E2F-4   Bach1   E2F-3a   E2F-5   E2F-2   E2F   E2F-1   HFH-1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNMT2 promoter sequence
   Search Chromatin IP Primers for NMT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NMT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

NMT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMT2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M015144:  view genomic region     (about GC identifiers)

Start:
15,144,583 bp from pter      End:
15,210,695 bp from pter
Size:
66,113 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NMT2_HUMAN, O60551 (See protein sequence)
Recommended Name: Glycylpeptide N-tetradecanoyltransferase 2  
Size: 498 amino acids; 56980 Da
Caution: Sequence AAF36406.2 was incorrectly indicated as originating from bovine
Secondary accessions: B0YJ49 Q53Y38 Q5VUC8 Q9BRB4

Explore the universe of human proteins at neXtProt for NMT2: NX_O60551

Explore proteomics data for NMT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NMT2 (O60551) (see all 17)
     KLVGFIS  EFLLWAL  WALRPPG  NYVEDDD 


    See NMT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004799.1  
    ENSEMBL proteins: 
     ENSP00000367407   ENSP00000367392   ENSP00000444616   ENSP00000438945  
    Reactome Protein details: O60551

    NMT2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for NMT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR000903 MyristoylCoA_TrFase
     IPR022678 MyristoylCoA_TrFase_CS
     IPR022676 MyristoylCoA_TrFase_N
     IPR016181 Acyl_CoA_acyltransferase
     IPR022677 MyristoylCoA_TrFase_C

    Graphical View of Domain Structure for InterPro Entry O60551

    ProtoNet protein and cluster: O60551

    1 Blocks protein domain: IPB000903 Myristoyl-CoA:protein N-myristoyltransferase

    UniProtKB/Swiss-Prot: NMT2_HUMAN, O60551
    Similarity: Belongs to the NMT family


    NMT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMT2_HUMAN, O60551
    Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins
    Catalytic activity: Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide

         Enzyme Number (IUBMB): EC 2.3.1.971 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS9506952
    GO:0004379glycylpeptide N-tetradecanoyltransferase activity IEA--
         
    NMT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Nmt2 (no phenotypes)

    NMT2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NMT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NMT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NMT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NMT2

    miRNA
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    Block miRNA regulation of human, mouse, rat NMT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NMT2 (see all 75):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-759 hsa-miR-29a* hsa-miR-3622a-5p hsa-miR-455-5p hsa-miR-34c-5p hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidNMT2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NMT2
    Predesigned siRNA for gene silencing in human, mouse, rat NMT2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NMT2 (NM_004808)
    Sino Biological Human cDNA Clone for NMT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMT2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMT2_HUMAN, O60551: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    golgi apparatus4
    plasma membrane4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    NMT2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NMT2 About    
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    Membrane binding and targetting of GAG proteins0.00
    Late Phase of HIV Life Cycle0.91
    Assembly Of The HIV Virion0.00
    HIV Infection0.62
    2The phototransduction cascade
    The phototransduction cascade0.51
    Inactivation, recovery and regulation of the phototransduction cascade0.49
    3Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    4Signaling by GPCR
    Signal Transduction0.58
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for NMT2
        Membrane binding and targetting of GAG proteins
    Inactivation, recovery and regulation of the phototransduction cascade



    NMT2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NMT2
    Interactions:

        GeneGlobe Interaction Network for NMT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NMT2 (O605512, 3 ENSP000003674074) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253462 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253462 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253462 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253462 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253462 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006499N-terminal protein myristoylation IEA--
    GO:0007603phototransduction, visible light TAS--
    GO:0009249protein lipoylation TAS9506952
    GO:0016032viral process TAS--
    GO:0016056rhodopsin mediated signaling pathway TAS--

    NMT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NMT2

    2 HMDB Compounds for NMT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Tetradecanoyl-CoAMyristoyl-CoA (see all 8)3130-72-1--

    4 DrugBank Compounds for NMT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Myristoyl-Coa-- 3130-72-1target--17139284 17016423 10592235
    S-(2-Oxo)Pentadecylcoa-- --target--17139284 17016423 10592235
    (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE-- --target--10592235
    1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NMT2 gene: 
    NM_004808.2  

    Unigene Cluster for NMT2:

    N-myristoyltransferase 2
    Hs.60339  [show with all ESTs]
    Unigene Representative Sequence: NM_004808
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466201 ENST00000486786 ENST00000378165(uc010qbz.1 uc001inz.1 uc001ioa.1)
    ENST00000378150 ENST00000478580 ENST00000535341 ENST00000540259
    miRNA
    Products:
         
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    Selected qRT-PCR Assays for microRNAs that regulate NMT2 (see all 75):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-759 hsa-miR-29a* hsa-miR-3622a-5p hsa-miR-455-5p hsa-miR-34c-5p hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidNMT2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NMT2 (NM_004808)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMT2
    Primer
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    OriGene qPCR primer pairs and template standards for NMT2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NMT2
      QuantiTect SYBR Green Assays in human, mouse, rat NMT2
      QuantiFast Probe-based Assays in human, mouse, rat NMT2

    Additional mRNA sequence: 

    AF043325.1 AF086423.1 AK025065.1 AK094904.1 AK123732.1 AK295277.1 AK302101.1 AK315085.1 
    BC005232.1 BC006376.2 BT007024.1 

    8 DOTS entries:

    DT.453645  DT.100780667  DT.100008423  DT.102831295  DT.112361  DT.121229571  DT.432156  DT.95358209 

    Selected AceView cDNA sequences (see all 95):

    BQ889269 BC005232 CB135826 CR608984 BM764383 CB153440 BM905788 AW614574 
    BX459412 BU633845 BT007024 AA364769 BU192989 AI146985 BX442217 BC006376 
    CB153252 AK094904 AW611798 BG748131 CD171673 AI022202 AI808821 W78134 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NMT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NMT2 Expression
    About this image

    NMT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NMT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.60339
        Custom PCR Arrays for NMT2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NMT2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmt21 , 5 N-myristoyltransferase 21, 5 88.76(n)1
    95.78(a)1
      2 (1.84 cM)5
    181081  NM_008708.11  NP_032734.11 
     32842125 
    chicken
    (Gallus gallus)
    Aves NMT21 N-myristoyltransferase 2 84.27(n)
    94.38(a)
      420529  XM_418632.4  XP_418632.2 
    lizard
    (Anolis carolinensis)
    Reptilia NMT26
    N-myristoyltransferase 2
    83(a)
    1 ↔ 1
    6(19206392-19227872)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nmt11 N-myristoyltransferase 1 77.71(n)
    88.96(a)
      779719  NM_001078798.1  NP_001072266.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nmt21 N-myristoyltransferase 2 75(n)
    86.59(a)
      556483  NM_001199754.1  NP_001186683.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nmt3 N-terminal protein myristoylation
    glycyl-peptide
    more
    66(a)   66B10   --
    worm
    (Caenorhabditis elegans)
    Secernentea T17E9.2a3
    nmt-11
    nmt-11 57(a)
    (best of 2)3
    58.16(n)1
    55.74(a)1
      III(6186548-6188081)3
    1758611  NM_065924.31  NP_498325.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NMT11 NMT1 48.7(n)
    45.34(a)
      850892   NP_013296.1 


    ENSEMBL Gene Tree for NMT2 (if available)
    TreeFam Gene Tree for NMT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NMT2 gene
    NMT12  
    1 SIMAP similar gene for NMT2 using alignment to 6 protein entries:     NMT2_HUMAN (see all proteins):
    NMT1

    NMT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NMT2 (see all 1493)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs752550411,2
    C,F--15122020(+) GTCCCG/ATATAG 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1876636031,2
    --15122087(+) GAGAAC/TTGGAA 1 -- int10--------
    rs1495637371,2
    --15147288(+) TTTAGA/CGAAAA 1 -- ds50010--------
    rs1819338651,2
    --15147335(+) TTTGAC/TTGGGT 1 -- ds50010--------
    rs748436911,2
    C,F--15147358(+) CATTAC/TGTGAT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs736024871,2
    C,F--15147375(+) ACCTCC/TTTGGA 1 -- ds50012Minor allele frequency- T:0.22WA 120
    rs1865773531,2
    --15147514(+) ACCGAC/TGCTCT 1 -- ds50010--------
    rs1431845931,2
    C--15147642(+) TCTCTC/TGATTT 1 -- ds50010--------
    rs779425391,2
    C,F--15147748(+) GTTTTA/GAATCT 1 -- ds50014Minor allele frequency- G:0.18NA CSA WA 242
    rs793025211,2
    C,F--15147768(+) TATCCA/GTTGCA 1 -- ds50011Minor allele frequency- G:0.09WA 118

    HapMap Linkage Disequilibrium report for NMT2 (15144583 - 15210695 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NMT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666604CNV Deletion23128226
    nsv5910CNV Insertion18451855
    esv2465251CNV Insertion19546169
    nsv831794CNV Loss17160897
    nsv894899CNV Gain21882294
    dgv618n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): NMT2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NMT2
    DNA2.0 Custom Variant and Variant Library Synthesis for NMT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603801    OMIM disorders: --

    4 diseases for NMT2:    
    About MalaCards
    impotence    hiv-1    esophagitis    adenocarcinoma


    NMT2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for NMT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 30.3 2 17390089 (1), 16530191 (1)
    adenocarcinoma 17.7 2 17390089 (1), 16530191 (1)
    tumors 0 3 16123142 (2)

    Genetic Association Database (GAD): NMT2
    Human Genome Epidemiology (HuGE) Navigator: NMT2 (4 documents)

    Export disorders for NMT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NMT2 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with NMT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A second mammalian N-myristoyltransferase. (PubMed id 9506952)1, 2, 3, 9 Giang D.K. and Cravatt B.F. (J. Biol. Chem. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef. (PubMed id 18089753)1, 9 Seaton K.E. and Smith C.D. (J. Gen. Virol. 2008)
    7. N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system. (PubMed id 16530191)1, 9 Selvakumar P....Sharma R.K. (FEBS Lett. 2006)
    8. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. (PubMed id 16123142)1, 9 Ducker C.E....Smith C.D. (Mol. Cancer Res. 2005)
    9. Is the disruption of an N-myristoyltransferase (NMT2) associated with hypoplastic testes? (PubMed id 17568424)1, 9 Quintero-Rivera F....Harris D.J. (Am. J. Med. Genet. A 2007)
    10. Genes associated with telomerase activity levels in esophageal carcinoma cell lines. (PubMed id 16364039)1, 9 Bergqvist M....Paulsson-Karlsson Y. (Dis. Esophagus 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9397 HGNC: 7858 AceView: NMT2 Ensembl:ENSG00000152465 euGenes: HUgn9397
    ECgene: NMT2 H-InvDB: NMT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NMT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NMT2 gene:
    Search GeneIP for patents involving NMT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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