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Aliases for NMT2 Gene

Aliases for NMT2 Gene

  • N-Myristoyltransferase 2 2 3 5
  • EC 2.3.1.97 4 63
  • Myristoyl-CoA:Protein N-Myristoyltransferase 2 4
  • Peptide N-Myristoyltransferase 2 4
  • Type II N-Myristoyltransferase 4
  • NMT 2 4

External Ids for NMT2 Gene

Previous GeneCards Identifiers for NMT2 Gene

  • GC10M015132
  • GC10M015300
  • GC10M015153
  • GC10M015189
  • GC10M015172
  • GC10M015060

Summaries for NMT2 Gene

Entrez Gene Summary for NMT2 Gene

  • This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for NMT2 Gene

NMT2 (N-Myristoyltransferase 2) is a Protein Coding gene. Among its related pathways are Infectious disease and Phototransduction. GO annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity. An important paralog of this gene is NMT1.

UniProtKB/Swiss-Prot for NMT2 Gene

  • Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Gene Wiki entry for NMT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMT2 Gene

Genomics for NMT2 Gene

Regulatory Elements for NMT2 Gene

Enhancers for NMT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NMT2 on UCSC Golden Path with GeneCards custom track

Promoters for NMT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NMT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NMT2 Gene

Chromosome:
10
Start:
15,102,584 bp from pter
End:
15,168,705 bp from pter
Size:
66,122 bases
Orientation:
Minus strand

Genomic View for NMT2 Gene

Genes around NMT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMT2 Gene

Proteins for NMT2 Gene

  • Protein details for NMT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60551-NMT2_HUMAN
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 2
    Protein Accession:
    O60551
    Secondary Accessions:
    • B0YJ49
    • Q53Y38
    • Q5VUC8
    • Q9BRB4

    Protein attributes for NMT2 Gene

    Size:
    498 amino acids
    Molecular mass:
    56980 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NMT2 Gene

neXtProt entry for NMT2 Gene

Proteomics data for NMT2 Gene at MOPED

Post-translational modifications for NMT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NMT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NMT2 Gene

Graphical View of Domain Structure for InterPro Entry

O60551

UniProtKB/Swiss-Prot:

NMT2_HUMAN :
  • Belongs to the NMT family.
Family:
  • Belongs to the NMT family.
genes like me logo Genes that share domains with NMT2: view

No data available for Gene Families for NMT2 Gene

Function for NMT2 Gene

Molecular function for NMT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
UniProtKB/Swiss-Prot Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Enzyme Numbers (IUBMB) for NMT2 Gene

genes like me logo Genes that share phenotypes with NMT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NMT2

miRNA for NMT2 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMT2 Gene

Localization for NMT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMT2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMT2 Gene COMPARTMENTS Subcellular localization image for NMT2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
plasma membrane 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with NMT2: view

Pathways & Interactions for NMT2 Gene

genes like me logo Genes that share pathways with NMT2: view

Gene Ontology (GO) - Biological Process for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006499 N-terminal protein myristoylation IEA --
GO:0007603 phototransduction, visible light TAS --
GO:0016032 viral process TAS --
GO:0018008 N-terminal peptidyl-glycine N-myristoylation IDA 25255805
GO:0019068 virion assembly TAS --
genes like me logo Genes that share ontologies with NMT2: view

No data available for SIGNOR curated interactions for NMT2 Gene

Drugs & Compounds for NMT2 Gene

(5) Drugs for NMT2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
myristoyl-coa Experimental Pharma Target 0
(Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE Experimental Pharma Target 0
1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL Experimental Pharma Target 0
S-(2-Oxo)Pentadecylcoa Experimental Pharma Target 0
Coenzyme A Nutra 0
genes like me logo Genes that share compounds with NMT2: view

Transcripts for NMT2 Gene

Unigene Clusters for NMT2 Gene

N-myristoyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMT2 Gene

No ASD Table

Relevant External Links for NMT2 Gene

GeneLoc Exon Structure for
NMT2
ECgene alternative splicing isoforms for
NMT2

Expression for NMT2 Gene

mRNA expression in normal human tissues for NMT2 Gene

Protein differential expression in normal tissues from HIPED for NMT2 Gene

This gene is overexpressed in CD8 Tcells (8.8), Testis (8.0), Lung (6.7), Peripheral blood mononuclear cells (6.3), and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMT2 Gene



SOURCE GeneReport for Unigene cluster for NMT2 Gene Hs.60339

genes like me logo Genes that share expression patterns with NMT2: view

Protein tissue co-expression partners for NMT2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NMT2 Gene

Orthologs for NMT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NMT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NMT2 35
  • 90.36 (n)
  • 94.98 (a)
NMT2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMT2 35
  • 84.65 (n)
  • 87.94 (a)
NMT2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmt2 35
  • 88.76 (n)
  • 95.78 (a)
Nmt2 16
Nmt2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NMT2 35
  • 99.52 (n)
  • 100 (a)
NMT2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmt2 35
  • 88.35 (n)
  • 95.18 (a)
oppossum
(Monodelphis domestica)
Mammalia NMT2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMT2 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMT2 35
  • 84.27 (n)
  • 94.38 (a)
NMT2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMT2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmt1 35
  • 77.71 (n)
  • 88.96 (a)
zebrafish
(Danio rerio)
Actinopterygii nmt2 35
  • 75 (n)
  • 86.59 (a)
nmt2 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nmt 37
  • 66 (a)
Nmt 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T17E9.2a 37
  • 57 (a)
T17E9.2b 37
  • 54 (a)
nmt-1 35
  • 58.16 (n)
  • 55.74 (a)
nmt-1 36
  • 53 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR077C 35
  • 52.37 (n)
  • 48.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19537g 35
  • 52.32 (n)
  • 47.34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMT1 35
  • 48.7 (n)
  • 45.34 (a)
NMT1 36
  • 41 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8619 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06925 35
  • 53.59 (n)
  • 51.95 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2G2.11 35
  • 53.48 (n)
  • 51.87 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8123 36
  • 56 (a)
OneToMany
Species with no ortholog for NMT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMT2 Gene

ENSEMBL:
Gene Tree for NMT2 (if available)
TreeFam:
Gene Tree for NMT2 (if available)

Paralogs for NMT2 Gene

Paralogs for NMT2 Gene

(1) SIMAP similar genes for NMT2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NMT2: view

Variants for NMT2 Gene

Sequence variations from dbSNP and Humsavar for NMT2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3814170 -- 15,170,215(-) TGCTT(C/T)TATCC upstream-variant-2KB
rs7091245 -- 15,169,740(+) AATAG(A/G)AGACC upstream-variant-2KB
rs4330986 -- 15,145,799(+) CAGAG(C/T)AGATC intron-variant
rs7092705 -- 15,157,569(+) AGGCT(A/G)CAGGT intron-variant
rs7094565 -- 15,169,561(+) GGGAC(A/T)TGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NMT2 Gene

Variant ID Type Subtype PubMed ID
nsv831794 CNV Loss 17160897
dgv618n71 CNV Gain 21882294
nsv894899 CNV Gain 21882294
nsv5910 CNV Insertion 18451855
esv2666604 CNV Deletion 23128226
esv2465251 CNV Insertion 19546169

Variation tolerance for NMT2 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMT2 Gene

Human Gene Mutation Database (HGMD)
NMT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMT2 Gene

Disorders for NMT2 Gene

Relevant External Links for NMT2

Genetic Association Database (GAD)
NMT2
Human Genome Epidemiology (HuGE) Navigator
NMT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMT2

No disorders were found for NMT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMT2 Gene

Publications for NMT2 Gene

  1. A second mammalian N-myristoyltransferase. (PMID: 9506952) Giang D.K. … Cravatt B.F. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef. (PMID: 18089753) Seaton K.E. … Smith C.D. (J. Gen. Virol. 2008) 3 23
  3. Is the disruption of an N-myristoyltransferase (NMT2) associated with hypoplastic testes? (PMID: 17568424) Quintero-Rivera F. … Harris D.J. (Am. J. Med. Genet. A 2007) 3 23
  4. Genes associated with telomerase activity levels in esophageal carcinoma cell lines. (PMID: 16364039) Bergqvist M. … Paulsson-Karlsson Y. (Dis. Esophagus 2006) 3 23
  5. N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system. (PMID: 16530191) Selvakumar P. … Sharma R.K. (FEBS Lett. 2006) 3 23

Products for NMT2 Gene

Sources for NMT2 Gene

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