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Aliases for NMT2 Gene

Aliases for NMT2 Gene

  • N-Myristoyltransferase 2 2 3
  • EC 2.3.1.97 4 63
  • Myristoyl-CoA:Protein N-Myristoyltransferase 2 4
  • Peptide N-Myristoyltransferase 2 4
  • Type II N-Myristoyltransferase 4
  • NMT 2 4

External Ids for NMT2 Gene

Summaries for NMT2 Gene

Entrez Gene Summary for NMT2 Gene

  • N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases. [provided by RefSeq, Jul 2008]

GeneCards Summary for NMT2 Gene

NMT2 (N-Myristoyltransferase 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity. An important paralog of this gene is NMT1.

UniProtKB/Swiss-Prot for NMT2 Gene

  • Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Gene Wiki entry for NMT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMT2 Gene

Genomics for NMT2 Gene

Genomic Location for NMT2 Gene

Start:
15,102,584 bp from pter
End:
15,168,704 bp from pter
Size:
66,121 bases
Orientation:
Minus strand

Genomic View for NMT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMT2 Gene

Regulatory Elements for NMT2 Gene

Proteins for NMT2 Gene

  • Protein details for NMT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60551-NMT2_HUMAN
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 2
    Protein Accession:
    O60551
    Secondary Accessions:
    • B0YJ49
    • Q53Y38
    • Q5VUC8
    • Q9BRB4

    Protein attributes for NMT2 Gene

    Size:
    498 amino acids
    Molecular mass:
    56980 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NMT2 Gene

neXtProt entry for NMT2 Gene

Proteomics data for NMT2 Gene at MOPED

Post-translational modifications for NMT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NMT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for NMT2 Gene

Graphical View of Domain Structure for InterPro Entry

O60551

UniProtKB/Swiss-Prot:

NMT2_HUMAN
Family:
  • Belongs to the NMT family.:
    • O60551
genes like me logo Genes that share domains with NMT2: view

No data available for Gene Families for NMT2 Gene

Function for NMT2 Gene

Molecular function for NMT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
UniProtKB/Swiss-Prot Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Enzyme Numbers (IUBMB) for NMT2 Gene

Gene Ontology (GO) - Molecular Function for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity IDA 25255805
genes like me logo Genes that share ontologies with NMT2: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NMT2 Gene

Localization for NMT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMT2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMT2 Gene COMPARTMENTS Subcellular localization image for NMT2 gene
Compartment Confidence
cytosol 4
golgi apparatus 4
plasma membrane 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0019898 extrinsic component of membrane IDA 9506952
genes like me logo Genes that share ontologies with NMT2: view

Pathways for NMT2 Gene

genes like me logo Genes that share pathways with NMT2: view

Pathways by source for NMT2 Gene

Gene Ontology (GO) - Biological Process for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006499 N-terminal protein myristoylation --
GO:0007603 phototransduction, visible light TAS --
GO:0009249 protein lipoylation --
GO:0016032 viral process TAS --
GO:0016056 rhodopsin mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with NMT2: view

Compounds for NMT2 Gene

(2) HMDB Compounds for NMT2 Gene

Compound Synonyms Cas Number PubMed IDs
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
Tetradecanoyl-CoA
  • Myristoyl-CoA
3130-72-1
genes like me logo Genes that share compounds with NMT2: view

Transcripts for NMT2 Gene

Unigene Clusters for NMT2 Gene

N-myristoyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMT2 Gene

No ASD Table

Relevant External Links for NMT2 Gene

GeneLoc Exon Structure for
NMT2
ECgene alternative splicing isoforms for
NMT2

Expression for NMT2 Gene

mRNA expression in normal human tissues for NMT2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMT2 Gene

SOURCE GeneReport for Unigene cluster for NMT2 Gene Hs.60339

genes like me logo Genes that share expressions with NMT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NMT2 Gene

Orthologs for NMT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NMT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMT2 35
  • 99.52 (n)
  • 100 (a)
NMT2 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NMT2 35
  • 90.36 (n)
  • 94.98 (a)
NMT2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMT2 35
  • 84.65 (n)
  • 87.94 (a)
NMT2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmt2 35
  • 88.76 (n)
  • 95.78 (a)
Nmt2 16
Nmt2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMT2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMT2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmt2 35
  • 88.35 (n)
  • 95.18 (a)
chicken
(Gallus gallus)
Aves NMT2 35
  • 84.27 (n)
  • 94.38 (a)
NMT2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMT2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmt1 35
  • 77.71 (n)
  • 88.96 (a)
zebrafish
(Danio rerio)
Actinopterygii nmt2 35
  • 75 (n)
  • 86.59 (a)
nmt2 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nmt 36
  • 56 (a)
OneToMany
Nmt 37
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea nmt-1 35
  • 58.16 (n)
  • 55.74 (a)
nmt-1 36
  • 53 (a)
OneToMany
T17E9.2a 37
  • 57 (a)
T17E9.2b 37
  • 54 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR077C 35
  • 52.37 (n)
  • 48.48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMT1 35
  • 48.7 (n)
  • 45.34 (a)
NMT1 36
  • 41 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19537g 35
  • 52.32 (n)
  • 47.34 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06925 35
  • 53.59 (n)
  • 51.95 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2G2.11 35
  • 53.48 (n)
  • 51.87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8619 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8123 36
  • 56 (a)
OneToMany
Species with no ortholog for NMT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMT2 Gene

ENSEMBL:
Gene Tree for NMT2 (if available)
TreeFam:
Gene Tree for NMT2 (if available)

Paralogs for NMT2 Gene

Paralogs for NMT2 Gene

Selected SIMAP similar genes for NMT2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NMT2: view

Variants for NMT2 Gene

Sequence variations from dbSNP and Humsavar for NMT2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs745220 -- 15,105,914(+) AATTA(C/T)GTAAA utr-variant-3-prime
rs913038 -- 15,106,548(+) CAAGA(A/G)AGGTC utr-variant-3-prime
rs1054657 -- 15,107,981(-) TCTAT(A/G)CTGAT utr-variant-3-prime, intron-variant
rs1133401 -- 15,108,283(-) cttga(A/G)cctga utr-variant-3-prime, intron-variant
rs1133402 -- 15,108,278(-) GCCTG(A/G)GAGGT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMT2 Gene

Variant ID Type Subtype PubMed ID
nsv831794 CNV Loss 17160897
dgv618n71 CNV Gain 21882294
nsv894899 CNV Gain 21882294
nsv5910 CNV Insertion 18451855
esv2666604 CNV Deletion 23128226
esv2465251 CNV Insertion 19546169

Relevant External Links for NMT2 Gene

HapMap Linkage Disequilibrium report
NMT2
Human Gene Mutation Database (HGMD)
NMT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMT2 Gene

Disorders for NMT2 Gene

(3) Novoseek inferred disease relationships for NMT2 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 30.3 2
adenocarcinoma 17.7 2
tumors 0 2

Relevant External Links for NMT2

Genetic Association Database (GAD)
NMT2
Human Genome Epidemiology (HuGE) Navigator
NMT2
genes like me logo Genes that share disorders with NMT2: view

No data available for UniProtKB/Swiss-Prot for NMT2 Gene

Publications for NMT2 Gene

  1. A second mammalian N-myristoyltransferase. (PMID: 9506952) Giang D.K. … Cravatt B.F. (J. Biol. Chem. 1998) 2 3 4 23
  2. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. (PMID: 16123142) Ducker C.E. … Smith C.D. (Mol. Cancer Res. 2005) 3 23
  3. Genes associated with telomerase activity levels in esophageal carcinoma cell lines. (PMID: 16364039) Bergqvist M. … Paulsson-Karlsson Y. (Dis. Esophagus 2006) 3 23
  4. N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system. (PMID: 16530191) Selvakumar P. … Sharma R.K. (FEBS Lett. 2006) 3 23
  5. N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef. (PMID: 18089753) Seaton K.E. … Smith C.D. (J. Gen. Virol. 2008) 3 23

Products for NMT2 Gene

Sources for NMT2 Gene

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