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Aliases for NMT2 Gene

Aliases for NMT2 Gene

  • N-Myristoyltransferase 2 2 3 5
  • EC 2.3.1.97 4 58
  • Myristoyl-CoA:Protein N-Myristoyltransferase 2 4
  • Peptide N-Myristoyltransferase 2 4
  • Type II N-Myristoyltransferase 4
  • NMT 2 4

External Ids for NMT2 Gene

Previous GeneCards Identifiers for NMT2 Gene

  • GC10M015132
  • GC10M015300
  • GC10M015153
  • GC10M015189
  • GC10M015172
  • GC10M015060

Summaries for NMT2 Gene

Entrez Gene Summary for NMT2 Gene

  • This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for NMT2 Gene

NMT2 (N-Myristoyltransferase 2) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Phototransduction. GO annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity. An important paralog of this gene is NMT1.

UniProtKB/Swiss-Prot for NMT2 Gene

  • Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Gene Wiki entry for NMT2 Gene

Additional gene information for NMT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMT2 Gene

Genomics for NMT2 Gene

Regulatory Elements for NMT2 Gene

Enhancers for NMT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H015195 1.2 Ensembl ENCODE dbSUPER 16.7 -28.6 -28601 3 PKNOX1 ATF1 L3MBTL2 JUN ZBTB40 ATF2 JUND POLR2A IKZF1 ZNF512 NMT2 LOC105376433 ENSG00000228181
GH10H015199 1.3 Ensembl ENCODE dbSUPER 12.7 -32.7 -32714 4 SOX13 ESRRA JUN BMI1 ZEB1 TEAD3 HIC1 CTBP1 GATA3 ZNF366 NMT2 RPP38 C10orf111 GAPDHP45 FAM171A1 LOC105376433 ENSG00000228181
GH10H015167 1 ENCODE 11.6 -0.7 -661 3 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 GLIS2 HSPA14 NMT2 RPP38 ENSG00000228181
GH10H015254 1 Ensembl ENCODE 10.7 -86.1 -86052 1 HDAC1 SOX6 BHLHE40 EBF1 ELF1 MEF2D ZFHX2 POLR2A FOXK2 IKZF1 FAM171A1 ENSG00000228181 NMT2 LOC105376434
GH10H015207 1.2 FANTOM5 Ensembl ENCODE 6 -39.8 -39794 1 IRF2 CBFB ZNF10 ZBTB40 CREB1 ETV6 MLLT1 RUNX3 MEIG1 NMT2 CDNF OLAH C10orf111 LOC105376433 LOC105376434
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NMT2 on UCSC Golden Path with GeneCards custom track

Promoters for NMT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000024901 605 2201 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GLIS2 ZNF143 ZNF207

Genomic Location for NMT2 Gene

Chromosome:
10
Start:
15,102,584 bp from pter
End:
15,168,705 bp from pter
Size:
66,122 bases
Orientation:
Minus strand

Genomic View for NMT2 Gene

Genes around NMT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMT2 Gene

Proteins for NMT2 Gene

  • Protein details for NMT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60551-NMT2_HUMAN
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 2
    Protein Accession:
    O60551
    Secondary Accessions:
    • B0YJ49
    • Q53Y38
    • Q5VUC8
    • Q9BRB4

    Protein attributes for NMT2 Gene

    Size:
    498 amino acids
    Molecular mass:
    56980 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NMT2 Gene

neXtProt entry for NMT2 Gene

Selected DME Specific Peptides for NMT2 Gene

O60551:
  • KLVGFIS
  • IIDTFVVE
  • GDGNLQYYLYNW
  • EFLLWAL
  • HKSLKAAYSFYN
  • TPLLDLMSDAL
  • WALRPPG
  • INFLCVHKKLRSKR
  • FRFDYSPEFL
  • YWHRSLNP
  • NYVEDDD
  • QAVYTAGV
  • FWDTQPVPK
  • EITRRVN
  • QWHCGVRV
  • EVKFSHLSRNMT
  • TDFLSFYTLPST

Post-translational modifications for NMT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NMT2 Gene

Gene Families for NMT2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

O60551

UniProtKB/Swiss-Prot:

NMT2_HUMAN :
  • Belongs to the NMT family.
Family:
  • Belongs to the NMT family.
genes like me logo Genes that share domains with NMT2: view

Function for NMT2 Gene

Molecular function for NMT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
UniProtKB/Swiss-Prot Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Enzyme Numbers (IUBMB) for NMT2 Gene

Phenotypes From GWAS Catalog for NMT2 Gene

Gene Ontology (GO) - Molecular Function for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NMT2: view
genes like me logo Genes that share phenotypes with NMT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NMT2

CRISPR Products

miRNA for NMT2 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NMT2
  • Applied Biological Materials Clones for NMT2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMT2 Gene

Localization for NMT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMT2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMT2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 9506952
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NMT2: view

Pathways & Interactions for NMT2 Gene

genes like me logo Genes that share pathways with NMT2: view

Gene Ontology (GO) - Biological Process for NMT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006499 N-terminal protein myristoylation IEA --
GO:0018008 N-terminal peptidyl-glycine N-myristoylation IDA 25255805
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
GO:0075733 intracellular transport of virus TAS --
genes like me logo Genes that share ontologies with NMT2: view

No data available for SIGNOR curated interactions for NMT2 Gene

Drugs & Compounds for NMT2 Gene

(5) Drugs for NMT2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
myristoyl-coa Experimental Pharma Target 0
(Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE Experimental Pharma Target 0
1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL Experimental Pharma Target 0
S-(2-Oxo)Pentadecylcoa Experimental Pharma Target 0
Coenzyme A Nutra 0
genes like me logo Genes that share compounds with NMT2: view

Transcripts for NMT2 Gene

Unigene Clusters for NMT2 Gene

N-myristoyltransferase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NMT2
  • Applied Biological Materials Clones for NMT2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NMT2 Gene

No ASD Table

Relevant External Links for NMT2 Gene

GeneLoc Exon Structure for
NMT2
ECgene alternative splicing isoforms for
NMT2

Expression for NMT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMT2 Gene

Protein differential expression in normal tissues from HIPED for NMT2 Gene

This gene is overexpressed in CD8 Tcells (8.8), Testis (8.0), Lung (6.7), Peripheral blood mononuclear cells (6.3), and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NMT2 Gene



Protein tissue co-expression partners for NMT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NMT2 Gene:

NMT2

SOURCE GeneReport for Unigene cluster for NMT2 Gene:

Hs.60339

Evidence on tissue expression from TISSUES for NMT2 Gene

  • Liver(4.3)
  • Skin(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with NMT2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMT2 Gene

Orthologs for NMT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NMT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMT2 33 34
  • 99.52 (n)
oppossum
(Monodelphis domestica)
Mammalia NMT2 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NMT2 33 34
  • 90.36 (n)
mouse
(Mus musculus)
Mammalia Nmt2 33 16 34
  • 88.76 (n)
rat
(Rattus norvegicus)
Mammalia Nmt2 33
  • 88.35 (n)
dog
(Canis familiaris)
Mammalia NMT2 33 34
  • 84.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NMT2 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMT2 34 33
  • 84.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMT2 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmt1 33
  • 77.71 (n)
zebrafish
(Danio rerio)
Actinopterygii nmt2 34 33
  • 75 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nmt 35 34
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea nmt-1 33 34
  • 58.16 (n)
T17E9.2a 35
  • 57 (a)
T17E9.2b 35
  • 54 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR077C 33
  • 52.37 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19537g 33
  • 52.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMT1 33 34
  • 48.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8123 34
  • 56 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06925 33
  • 53.59 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2G2.11 33
  • 53.48 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8619 33
Species where no ortholog for NMT2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMT2 Gene

ENSEMBL:
Gene Tree for NMT2 (if available)
TreeFam:
Gene Tree for NMT2 (if available)

Paralogs for NMT2 Gene

Paralogs for NMT2 Gene

(1) SIMAP similar genes for NMT2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NMT2: view

Variants for NMT2 Gene

Sequence variations from dbSNP and Humsavar for NMT2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000071187 -- 15,122,036(+) AATGC(A/T)AGTGG intron-variant
rs1000072753 -- 15,149,051(+) TGCCA(C/T)CACCA intron-variant
rs1000099667 -- 15,106,909(+) CAGCA(C/T)GGGAA intron-variant, utr-variant-3-prime
rs1000120230 -- 15,161,800(+) AAAAA(A/C/T)AAAAG intron-variant
rs1000122961 -- 15,159,935(+) AGATA(C/T)ACTCA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NMT2 Gene

Variant ID Type Subtype PubMed ID
esv2465251 CNV insertion 19546169
esv2666604 CNV deletion 23128226
esv3622437 CNV loss 21293372
nsv1068675 CNV deletion 25765185
nsv1078731 CNV insertion 25765185
nsv1122495 CNV deletion 24896259
nsv1146274 CNV insertion 26484159
nsv5910 CNV insertion 18451855
nsv831794 CNV loss 17160897
nsv947748 CNV duplication 23825009

Variation tolerance for NMT2 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMT2 Gene

Human Gene Mutation Database (HGMD)
NMT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMT2 Gene

Disorders for NMT2 Gene

Relevant External Links for NMT2

Genetic Association Database (GAD)
NMT2
Human Genome Epidemiology (HuGE) Navigator
NMT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMT2

No disorders were found for NMT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMT2 Gene

Publications for NMT2 Gene

  1. A second mammalian N-myristoyltransferase. (PMID: 9506952) Giang DK … Cravatt BF (The Journal of biological chemistry 1998) 2 3 4 22 60
  2. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. (PMID: 25255805) Thinon E … Tate EW (Nature communications 2014) 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef. (PMID: 18089753) Seaton KE … Smith CD (The Journal of general virology 2008) 3 22 60

Products for NMT2 Gene

  • Addgene plasmids for NMT2

Sources for NMT2 Gene

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