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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NMT2 Gene

protein-coding   GIFtS: 61
GCID: GC10M015144

N-myristoyltransferase 2
 Explore 7 diseases affiliated with
NMT2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NMT2    

Aliases
for NMT2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
N-Myristoyltransferase 21 2     NMT 22 3
Myristoyl-CoA:Protein N-Myristoyltransferase 22 3     EC 2.3.1.973 8
Peptide N-Myristoyltransferase 22 3     Glycylpeptide N-Tetradecanoyltransferase 22
Type II N-Myristoyltransferase2 3     

External Ids:    HGNC: 78581   Entrez Gene: 93972   Ensembl: ENSG000001524657   OMIM: 6038015   UniProtKB: O605513   

Export aliases for NMT2 gene to outside databases

Previous GC identifers: GC10M015132 GC10M015300 GC10M015153 GC10M015189 GC10M015172 GC10M015060


Summaries
for NMT2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NMT2:
N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It
transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue.
Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or
subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence identity with
human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NMT2_HUMAN, O60551
Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins

Gene Wiki entry for NMT2


Genomic Views
for NMT2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NMT2 gene promoter:
         SRF   E2F-4   Bach1   E2F-3a   E2F-5   E2F-2   E2F   E2F-1   HFH-1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NMT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NMT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

NMT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMT2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M015144:  view genomic region     (about GC identifiers)

Start:
 15,144,583 bp from pter      End:
 15,210,695 bp from pter
Size:
 66,113 bases      Orientation:
 minus strand

Proteins
for NMT2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NMT2_HUMAN, O60551 (See protein sequence)
Recommended Name: Glycylpeptide N-tetradecanoyltransferase 2  
Size: 498 amino acids; 56980 Da
Subcellular location: Cytoplasm
Caution: Sequence AAF36406.2 was incorrectly indicated as originating from bovine
Secondary accessions: B0YJ49 Q53Y38 Q5VUC8 Q9BRB4

Explore the universe of human proteins at neXtProt for NMT2: NX_O60551

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60551

    • 4/17 DME Specific Peptides for NMT2 (O60551) (see all 17)
     KLVGFIS  EFLLWAL  WALRPPG  NYVEDDD 

    NMT2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004799.1  
    ENSEMBL proteins: 
     ENSP00000367407   ENSP00000367392   ENSP00000367385   ENSP00000444616   ENSP00000438945  
    Reactome Protein details: O60551
    Human Recombinant Protein Products: 
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    Novus Biologicals NMT2 Proteins
    Novus Biologicals NMT2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NMT2
    Uscn Proteins for NMT2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--


    NMT2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NMT2

    Protein Domains /
    Families
    for NMT2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NMT2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016181 Acyl_CoA_acyltransferase
     IPR022677 MyristoylCoA_TrFase_C
     IPR000903 MyristoylCoA_TrFase
     IPR022678 MyristoylCoA_TrFase_CS
     IPR022676 MyristoylCoA_TrFase_N

    Graphical View of Domain Structure for InterPro Entry O60551

    ProtoNet protein and cluster: O60551

    1 Blocks protein family: IPB000903 Myristoyl-CoA:protein N-myristoyltransferase

    UniProtKB/Swiss-Prot: NMT2_HUMAN, O60551
    Similarity: Belongs to the NMT family


    Function
    for NMT2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NMT2_HUMAN, O60551
    Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins
    Catalytic activity: Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide

    Enzyme Number (IUBMB): EC 2.3.1.971 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMT2
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate NMT2 (see all 75):
    hsa-miR-3607-3p hsa-miR-607 hsa-miR-759 hsa-miR-29a* hsa-miR-3622a-5p hsa-miR-455-5p hsa-miR-34c-5p hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmid: NMT2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NMT2 (see all 7)
    OriGene shRNA RFP: NMT2
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NMT2

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMT2 

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    Search LifeMap BioReagents cell lines for NMT2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMT2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS9506952
    GO:0004379glycylpeptide N-tetradecanoyltransferase activity IEA--


    NMT2 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Nmt2 (no phenotypes)

    NMT2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NMT2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal Transduction
    		Membrane binding and targetting of GAG proteins0.36
    		Synthesis And Processing Of GAG, GAGPOL Polyproteins0.36
    		Assembly of HIV virion0.36
    2Late Phase of HIV Life Cycle
    		Late Phase of HIV Life Cycle1.00
    		HIV Life Cycle0.90
    3HIV Infection
    		HIV Infection1.00
    4Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/7        Reactome Pathways for NMT2 (see all 7)
        HIV Life Cycle
    HIV Infection
    Late Phase of HIV Life Cycle
    Assembly of HIV virion
    Synthesis And Processing Of GAG, GAGPOL Polyproteins



    NMT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NMT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/17 Interacting proteins for NMT2 (O605512, 3 ENSP000003674074) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104152, 3, ENSP000003296234MINT-1795413 I2D: score=2 STRING: ENSP00000329623
    CASP3P425742, 3, ENSP000003110324MINT-1795359 I2D: score=2 STRING: ENSP00000311032
    SMN1Q166372, 3MINT-8271366 I2D: score=2 
    SMN2Q166372, 3MINT-8271366 I2D: score=2 
    TP53P046372, 3, ENSP000002693054MINT-1795395 I2D: score=2 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006499N-terminal protein myristoylation IEA--
    GO:0009249protein lipoylation TAS9506952
    GO:0016032viral reproduction TAS--
    GO:0046788egress of virus within host cell TAS--


    NMT2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NMT2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NMT2

    2 HMDB Compounds for NMT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Tetradecanoyl-CoAMyristoyl-CoA (see all 8)3130-72-1--

    4 DrugBank Compounds for NMT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Myristoyl-Coa-- 3130-72-1target--17139284 17016423 10592235
    S-(2-Oxo)Pentadecylcoa-- --target--17139284 17016423 10592235
    (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE-- --target--10592235
    1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about NMT2 

    Transcripts
    for NMT2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NMT2 gene: 
    NM_004808.2  

    Unigene Cluster for NMT2:

    N-myristoyltransferase 2
    Hs.60339  [show with all ESTs]
    Unigene Representative Sequence: NM_004808
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466201 ENST00000486786 ENST00000378165(uc010qbz.1 uc001inz.1 uc001ioa.1)
    ENST00000378150 ENST00000378143 ENST00000478580 ENST00000535341 ENST00000540259


    miRNA
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    hsa-miR-3607-3p hsa-miR-607 hsa-miR-759 hsa-miR-29a* hsa-miR-3622a-5p hsa-miR-455-5p hsa-miR-34c-5p hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmid: NMT2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NMT2 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMT2
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF043325.1 AF086423.1 AK025065.1 AK094904.1 AK123732.1 AK295277.1 AK302101.1 AK315085.1 
    BC005232.1 BC006376.2 BT007024.1 

    8 DOTS entries:

    DT.453645  DT.100780667  DT.100008423  DT.102831295  DT.112361  DT.121229571  DT.432156  DT.95358209 

    24/95 AceView cDNA sequences (see all 95):

    CB135826 BC005232 AW611798 BM905788 BU192989 AA364769 BT007024 BU633845 
    AW614574 BX459412 CR608984 BM764383 CB153252 CB153440 BX442217 AK094904 
    BQ889269 AI146985 BC006376 BF698947 CA437591 NM_004808 AW959879 AK123732 

    GeneLoc Exon Structure


    Expression
    for NMT2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NMT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NMT2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NMT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NMT2

    SOURCE GeneReport for Unigene cluster: Hs.60339
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMT2

    Orthologs
    for NMT2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NMT2 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nmt21 , 5 N-myristoyltransferase 21, 5 88.76(n)1
    95.78(a)1    		   2 (1.84 cM)5
    181081  NM_008708.11  NP_032734.11 
     32842125 
    chicken
    (Gallus gallus)    		 Aves NMT21 N-myristoyltransferase 2 84.27(n)
    94.38(a)    		   420529  XM_418632.3  XP_418632.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NMT26
    		 --
    		 80(a)
    		 1 ↔ 1
    		 6(19206614-19227872)
    zebrafish
    (Danio rerio)    		 Actinopterygii nmt21 N-myristoyltransferase 2 75(n)
    86.59(a)    		   556483  NM_001199754.1  NP_001186683.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Nmt3 N-terminal protein myristoylation
    glycyl-peptide more    		 66(a)   66B10   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T17E9.2a3
    nmt-11    		 Protein NMT-11 57(a)
    (best of 2)3
    58.08(n)1
    55.74(a)1    		   III(6186548-6188081)3
    1758611  NM_065924.21  NP_498325.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NMT16
    		 glycylpeptide N-tetradecanoyltransferase 1
    		 52(a)
    		 1 → many
    		 5(23074867-23076901)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 glycylpeptide N-tetradecanoyltransferase 1, putati...
    		 52(a)
    		 1 → many
    		 1(29411151-29412927)


    ENSEMBL Gene Tree for NMT2 (if available)
    TreeFam Gene Tree for NMT2 (if available) 

    Paralogs
    for NMT2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NMT2 gene
    NMT12  
    1 SIMAP similar gene for NMT2 using alignment to 6 protein entries:     NMT2_HUMAN (see all proteins):
    NMT1

    NMT2 for paralogs           About GeneDecksing



    Genomic Variants
    for NMT2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1285 NCBI SNPs in NMT2 are shown (see all 1285)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1495637371,2
    		--15147288(+) TTTAGA/CGAAAA 1 -- ds50010--------
    rs1819338651,2
    		--15147335(+) TTTGAC/TTGGGT 1 -- ds50010--------
    rs748436911,2
    		F,--15147358(+) CATTAC/TGTGAT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs736024871,2
    		C,--15147375(+) ACCTCC/TTTGGA 1 -- ds50012Minor allele frequency- T:0.22WA 120
    rs1865773531,2
    		--15147514(+) ACCGAC/TGCTCT 1 -- ds50010--------
    rs1431845931,2
    		--15147642(+) TCTCTC/TGATTT 1 -- ds50010--------
    rs779425391,2
    		C,F,--15147748(+) GTTTTA/GAATCT 1 -- ds50014Minor allele frequency- G:0.18NA CSA WA 242
    rs793025211,2
    		F,--15147768(+) TATCCA/GTTGCA 1 -- ds50011Minor allele frequency- G:0.09WA 118
    rs741232831,2
    		C,--15147817(+) GTTTAA/GTTCTC 1 -- ut312Minor allele frequency- G:0.07WA 120
    rs1396767281,2
    		C,--15147869(+) TGTAG-/TTATTATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NMT2 (15144583 - 15210695 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for NMT2
         2 Indels: 39726 100873
    Human Gene Mutation Database (HGMD): NMT2

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    Disorders / Diseases
    for NMT2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NMT2 for disorders           About GeneDecksing

    OMIM gene information: 603801    OMIM disorders: --

    7 diseases for NMT2:    About MalaCards
    impotence    colon cancer    esophageal carcinoma    esophagitis
    immunodeficiency    carcinoma    malaria

    3 Novoseek disease relationships for NMT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 30.3 2 17390089 (1), 16530191 (1)
    adenocarcinoma 17.7 2 17390089 (1), 16530191 (1)
    tumors 0 3 16123142 (2)

    Human Genome Epidemiology (HuGE) Navigator: NMT2 (4 documents)

    Export disorders for NMT2 gene to outside databases

    Publications
    for NMT2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NMT2 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with NMT2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A second mammalian N-myristoyltransferase. (PubMed id 9506952)1, 2, 3, 9 Giang D.K. and Cravatt B.F. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    4. N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef. (PubMed id 18089753)1, 9 Seaton K.E. and Smith C.D. (2008)
    5. N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system. (PubMed id 16530191)1, 9 Selvakumar P....Sharma R.K. (2006)
    6. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. (PubMed id 16123142)1, 9 Ducker C.E....Smith C.D. (2005)
    7. Is the disruption of an N-myristoyltransferase (NMT2) associated with hypoplastic testes? (PubMed id 17568424)1, 9 Quintero-Rivera F....Harris D.J. (2007)
    8. Genes associated with telomerase activity levels in esophageal carcinoma cell lines. (PubMed id 16364039)1, 9 Bergqvist M....Paulsson-Karlsson Y. (2006)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    External Searches for NMT2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NMT2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9397 HGNC: 7858 AceView: NMT2 Ensembl:ENSG00000152465 euGenes: HUgn9397
    ECgene: NMT2 H-InvDB: NMT2

    Other Databases showing NMT2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NMT2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NMT2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NMT2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NMT2 gene:
    Search GeneIP for patents involving NMT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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