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Aliases for NMT1 Gene

Aliases for NMT1 Gene

  • N-Myristoyltransferase 1 2 3 5
  • Myristoyl-CoA:Protein N-Myristoyltransferase 1 3 4
  • Alternative, Short Form NMT-S 2 3
  • Type I N-Myristoyltransferase 3 4
  • Long Form, NMT-L 2 3
  • EC 4 61
  • NMT 3 4
  • Myristoyl-CoA:Protein N-Myristoyltransferase 2
  • Glycylpeptide N-Tetradecanoyltransferase 1 3
  • Peptide N-Myristoyltransferase 1 4
  • NMT 1 4

External Ids for NMT1 Gene

Previous GeneCards Identifiers for NMT1 Gene

  • GC17M042667
  • GC17M045252
  • GC17P043149
  • GC17P043613
  • GC17P040494
  • GC17P043139
  • GC17P038903

Summaries for NMT1 Gene

Entrez Gene Summary for NMT1 Gene

  • Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

GeneCards Summary for NMT1 Gene

NMT1 (N-Myristoyltransferase 1) is a Protein Coding gene. Diseases associated with NMT1 include Gallbladder Cancer. Among its related pathways are Metabolism of fat-soluble vitamins and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity and myristoyltransferase activity. An important paralog of this gene is NMT2.

UniProtKB/Swiss-Prot for NMT1 Gene

  • Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Tocris Summary for NMT1 Gene

Gene Wiki entry for NMT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMT1 Gene

Genomics for NMT1 Gene

Regulatory Elements for NMT1 Gene

Enhancers for NMT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F044977 1 Ensembl ENCODE 20.9 -71.8 -71811 5.2 PKNOX1 MLX SIN3A YBX1 BRCA1 YY1 ZNF121 ZNF207 FOS ZNF263 GJC1 NMT1 CRHR1-IT1 KIF18B GFAP ENSG00000224911 GPATCH8 DCAKD EFTUD2 DBF4B
GH17F045089 1.5 FANTOM5 Ensembl ENCODE 16.6 +40.6 40596 4.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 DCAKD PLCD3 GFAP NMT1 ACBD4 HEXIM1 GPATCH8 ENSG00000224911 LOC102724391 EFTUD2
GH17F045029 0.2 ENCODE 12.3 -20.5 -20451 3.1 PKNOX1 ATF1 ARNT SIN3A ZNF48 GATA2 ZNF263 SP5 NCOA1 MBD2 DCAKD NMT1 KIF18B GFAP ENSG00000224911 C1QL1 HEXIM2 ENSG00000224505 CCDC103 EFTUD2
GH17F045020 0.7 Ensembl ENCODE 12.2 -30.2 -30186 2.5 ATF1 CREB3L1 ZFP64 ARID4B DMAP1 ZNF48 ZNF143 PAF1 ZNF263 SP5 DCAKD NMT1 C1QL1 GFAP ENSG00000224911 CCDC103 EFTUD2 FAM187A KIF18B HEXIM2
GH17F045006 0.6 FANTOM5 11.4 -44.5 -44455 0.3 CTCF ZIC2 RAD21 YY1 ZFHX2 PATZ1 MAZ HLF NFIL3 ZFP69B KIF18B CCDC103 EFTUD2 FAM187A C1QL1 GFAP ENSG00000224911 NMT1 DCAKD GC17M045006
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NMT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NMT1 Gene

45,051,610 bp from pter
45,109,016 bp from pter
57,407 bases
Plus strand

Genomic View for NMT1 Gene

Genes around NMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMT1 Gene

Proteins for NMT1 Gene

  • Protein details for NMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • A8K7C1
    • Q9UE09

    Protein attributes for NMT1 Gene

    496 amino acids
    Molecular mass:
    56806 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC09294.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NMT1 Gene

    Alternative splice isoforms for NMT1 Gene


neXtProt entry for NMT1 Gene

Selected DME Specific Peptides for NMT1 Gene


Post-translational modifications for NMT1 Gene

  • Ubiquitination at Lys 94
  • Modification sites at PhosphoSitePlus

Other Protein References for NMT1 Gene

Domains & Families for NMT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NMT family.
  • Belongs to the NMT family.
genes like me logo Genes that share domains with NMT1: view

No data available for Gene Families for NMT1 Gene

Function for NMT1 Gene

Molecular function for NMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
UniProtKB/Swiss-Prot Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Enzyme Numbers (IUBMB) for NMT1 Gene

Gene Ontology (GO) - Molecular Function for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019107 myristoyltransferase activity TAS --
genes like me logo Genes that share ontologies with NMT1: view
genes like me logo Genes that share phenotypes with NMT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NMT1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NMT1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMT1 Gene

Localization for NMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMT1 Gene

Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=Copurifies with ribosomes. {ECO:0000269 PubMed:9353336}.

Subcellular locations from

Jensen Localization Image for NMT1 Gene COMPARTMENTS Subcellular localization image for NMT1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 5
plasma membrane 5
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 9353336
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with NMT1: view

Pathways & Interactions for NMT1 Gene

genes like me logo Genes that share pathways with NMT1: view

Pathways by source for NMT1 Gene

Gene Ontology (GO) - Biological Process for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006499 N-terminal protein myristoylation TAS --
GO:0018008 N-terminal peptidyl-glycine N-myristoylation IDA 25255805
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS --
genes like me logo Genes that share ontologies with NMT1: view

No data available for SIGNOR curated interactions for NMT1 Gene

Drugs & Compounds for NMT1 Gene

(12) Drugs for NMT1 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
myristoyl-coa Experimental Pharma Target 0
(1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone Experimental Pharma Target, Target 0
[Cyclohexylethyl]-[[[[4-[2-Methyl-1-Imidazolyl-Butyl]Phenyl]Acetyl]-Seryl]-Lysinyl]-Amine Experimental Pharma Target 0
Tris DBA Pharma 0
Coenzyme A Nutra 0

(9) Additional Compounds for NMT1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Perhexiline maleate

(5) Tocris Compounds for NMT1 Gene

Compound Action Cas Number
(R)-(+)-Etomoxir sodium salt Carnitine palmitoyltransferase I (CPT1) inhibitor 828934-41-4
GGsTop Inhibitor of gamma-glutamyl transpeptidase (GGT) 926281-37-0
LDN 27219 Transglutaminase 2 (TG2) inhibitor; reversible 312946-37-5
P-3FAX-Neu5Ac Sialic acid analog; sialyltransferase inhibitor 117405-58-0
Perhexiline maleate Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor 6724-53-4

(1) ApexBio Compounds for NMT1 Gene

Compound Action Cas Number
Tris DBA 51364-51-3
genes like me logo Genes that share compounds with NMT1: view

Transcripts for NMT1 Gene

Unigene Clusters for NMT1 Gene

N-myristoyltransferase 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NMT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMT1 Gene

No ASD Table

Relevant External Links for NMT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NMT1 Gene

Protein differential expression in normal tissues from HIPED for NMT1 Gene

This gene is overexpressed in Bone marrow stromal cell (10.7) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NMT1 Gene

Protein tissue co-expression partners for NMT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NMT1 Gene:


SOURCE GeneReport for Unigene cluster for NMT1 Gene:


mRNA Expression by UniProt/SwissProt for NMT1 Gene:

Tissue specificity: Heart, gut, kidney, liver and placenta.
genes like me logo Genes that share expression patterns with NMT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NMT1 Gene

Orthologs for NMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NMT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NMT1 34 35
  • 99.66 (n)
(Canis familiaris)
Mammalia NMT1 34 35
  • 94.49 (n)
(Bos Taurus)
Mammalia NMT1 34 35
  • 93.08 (n)
(Mus musculus)
Mammalia Nmt1 34 16 35
  • 90.93 (n)
(Rattus norvegicus)
Mammalia Nmt1 34
  • 90.93 (n)
(Monodelphis domestica)
Mammalia NMT1 35
  • 90 (a)
(Gallus gallus)
Aves NMT1 34 35
  • 82.15 (n)
(Anolis carolinensis)
Reptilia NMT1 35
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nmt2 34
  • 76.38 (n)
Str.12909 34
African clawed frog
(Xenopus laevis)
Amphibia nmt1-prov 34
(Danio rerio)
Actinopterygii nmt1a 34 35
  • 74.97 (n)
wufc15d01 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001804 34
  • 65.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nmt 36 34 35
  • 63.38 (n)
(Caenorhabditis elegans)
Secernentea T17E9.2a 36
  • 57 (a)
T17E9.2b 36
  • 57 (a)
nmt-1 35
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMT1 35 37
  • 41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NMT1 34
  • 59.21 (n)
(Oryza sativa)
Liliopsida Os01g0708100 34
  • 62.23 (n)
Os.15143 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8123 35
  • 56 (a)
Species where no ortholog for NMT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMT1 Gene

Gene Tree for NMT1 (if available)
Gene Tree for NMT1 (if available)

Paralogs for NMT1 Gene

Paralogs for NMT1 Gene

(2) SIMAP similar genes for NMT1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NMT1: view

Variants for NMT1 Gene

Sequence variations from dbSNP and Humsavar for NMT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1005136 -- 45,086,878(+) TTCTT(G/T)CCAAC intron-variant
rs10491142 -- 45,090,495(+) ACTCT(C/G)TTTTA intron-variant
rs1053733 -- 45,105,660(+) ATTCT(A/G)GATAA utr-variant-3-prime
rs1053739 -- 45,105,740(+) TCCCT(A/G)GCAAA utr-variant-3-prime
rs10592246 -- 45,090,402(+) TGTCG(-/TTC)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMT1 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv527788 CNV loss 19592680
nsv833457 CNV loss 17160897
nsv953903 CNV deletion 24416366

Variation tolerance for NMT1 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMT1 Gene

Disorders for NMT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NMT1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
gallbladder cancer
  • gallbladder ca
- elite association - COSMIC cancer census association via MalaCards
Search NMT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NMT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NMT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMT1 Gene

Publications for NMT1 Gene

  1. Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae. (PMID: 1570339) Duronio R.J. … Gordon J.I. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 22 64
  2. A second mammalian N-myristoyltransferase. (PMID: 9506952) Giang D.K. … Cravatt B.F. (J. Biol. Chem. 1998) 3 4 22 64
  3. Characterization of human and rat brain myristoyl-CoA:protein N- myristoyltransferase: evidence for an alternative splice variant of the enzyme. (PMID: 9677304) Mcilhinney R.A.J. … Soloviev M. (Biochem. J. 1998) 3 4 22 64
  4. Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction. (PMID: 9353336) Glover C.J. … Felsted R.L. (J. Biol. Chem. 1997) 3 4 22 64
  5. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. (PMID: 25255805) Thinon E. … Tate E.W. (Nat. Commun. 2014) 3 4 64

Products for NMT1 Gene

Sources for NMT1 Gene

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