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Aliases for NMT1 Gene

Aliases for NMT1 Gene

  • N-Myristoyltransferase 1 2 3 5
  • Myristoyl-CoA:Protein N-Myristoyltransferase 1 3 4
  • Type I N-Myristoyltransferase 3 4
  • EC 4 63
  • NMT 3 4
  • Myristoyl-CoA:Protein N-Myristoyltransferase 2
  • Peptide N-Myristoyltransferase 1 4
  • Alternative, Short Form NMT-S 3
  • Short Form NMT-S 2
  • Long Form, NMT-L 3
  • Alternative 2
  • Long Form 2
  • NMT-L 2
  • NMT 1 4

External Ids for NMT1 Gene

Previous GeneCards Identifiers for NMT1 Gene

  • GC17M042667
  • GC17M045252
  • GC17P043149
  • GC17P043613
  • GC17P040494
  • GC17P043139
  • GC17P038903

Summaries for NMT1 Gene

Entrez Gene Summary for NMT1 Gene

  • Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

GeneCards Summary for NMT1 Gene

NMT1 (N-Myristoyltransferase 1) is a Protein Coding gene. Diseases associated with NMT1 include Gallbladder Cancer. Among its related pathways are Infectious disease and Phototransduction. GO annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity and myristoyltransferase activity. An important paralog of this gene is NMT2.

UniProtKB/Swiss-Prot for NMT1 Gene

  • Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Tocris Summary for NMT1 Gene

Gene Wiki entry for NMT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMT1 Gene

Genomics for NMT1 Gene

Regulatory Elements for NMT1 Gene

Enhancers for NMT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NMT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NMT1 Gene

45,051,610 bp from pter
45,109,016 bp from pter
57,407 bases
Plus strand

Genomic View for NMT1 Gene

Genes around NMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMT1 Gene

Proteins for NMT1 Gene

  • Protein details for NMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • A8K7C1
    • Q9UE09

    Protein attributes for NMT1 Gene

    496 amino acids
    Molecular mass:
    56806 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC09294.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NMT1 Gene

    Alternative splice isoforms for NMT1 Gene


neXtProt entry for NMT1 Gene

Proteomics data for NMT1 Gene at MOPED

Post-translational modifications for NMT1 Gene

  • Ubiquitination at Lys 94
  • Modification sites at PhosphoSitePlus

Other Protein References for NMT1 Gene

Domains & Families for NMT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NMT family.
  • Belongs to the NMT family.
genes like me logo Genes that share domains with NMT1: view

No data available for Gene Families for NMT1 Gene

Function for NMT1 Gene

Molecular function for NMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
UniProtKB/Swiss-Prot Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Enzyme Numbers (IUBMB) for NMT1 Gene

genes like me logo Genes that share phenotypes with NMT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NMT1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMT1 Gene

Localization for NMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMT1 Gene

Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=Copurifies with ribosomes. {ECO:0000269 PubMed:9353336}.

Subcellular locations from

Jensen Localization Image for NMT1 Gene COMPARTMENTS Subcellular localization image for NMT1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 5
plasma membrane 5
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS --
genes like me logo Genes that share ontologies with NMT1: view

Pathways & Interactions for NMT1 Gene

genes like me logo Genes that share pathways with NMT1: view

Pathways by source for NMT1 Gene

Gene Ontology (GO) - Biological Process for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007603 phototransduction, visible light TAS --
GO:0012501 programmed cell death TAS --
GO:0016032 viral process TAS --
GO:0097193 intrinsic apoptotic signaling pathway TAS --
genes like me logo Genes that share ontologies with NMT1: view

No data available for SIGNOR curated interactions for NMT1 Gene

Drugs & Compounds for NMT1 Gene

(10) Drugs for NMT1 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vigabatrin Approved Pharma Inhibition, Inhibitor GABA-T inhibitor 19
myristoyl-coa Experimental Pharma Target 0
(1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone Experimental Pharma Target, Target 0
[Cyclohexylethyl]-[[[[4-[2-Methyl-1-Imidazolyl-Butyl]Phenyl]Acetyl]-Seryl]-Lysinyl]-Amine Experimental Pharma Target 0
Ellagic acid Investigational Pharma Casein kinase 2 (CK2) inhibitor, Selective inhibitor of CK2. Also inhibits glutathione S-transferase 0

(10) Additional Compounds for NMT1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fumonisin B1
  • Fumonisin B1
  • Fungal metabolite from fusarium monliforme
  • Macrofusin
  • Macrofusine
Miglustat hydrochloride
SKF 91488 dihydrochloride

(5) Tocris Compounds for NMT1 Gene

Compound Action Cas Number
Ellagic acid Selective inhibitor of CK2. Also inhibits glutathione S-transferase 476-66-4
Fumonisin B1 Inhibitor of sphingosine N-acyltransferase 116355-83-0
Miglustat hydrochloride alpha-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases 210110-90-0
SKF 91488 dihydrochloride Histamine N-methyltransferase inhibitor 68941-21-9
Vigabatrin GABA-T inhibitor 60643-86-9
genes like me logo Genes that share compounds with NMT1: view

Transcripts for NMT1 Gene

Unigene Clusters for NMT1 Gene

N-myristoyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMT1 Gene

No ASD Table

Relevant External Links for NMT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NMT1 Gene

mRNA expression in normal human tissues for NMT1 Gene

Protein differential expression in normal tissues from HIPED for NMT1 Gene

This gene is overexpressed in Bone marrow stromal cell (10.7) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMT1 Gene

SOURCE GeneReport for Unigene cluster for NMT1 Gene Hs.532790

mRNA Expression by UniProt/SwissProt for NMT1 Gene

Tissue specificity: Heart, gut, kidney, liver and placenta.
genes like me logo Genes that share expression patterns with NMT1: view

Protein tissue co-expression partners for NMT1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NMT1 Gene

Orthologs for NMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NMT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NMT1 35
  • 93.08 (n)
  • 98.99 (a)
NMT1 36
  • 99 (a)
(Canis familiaris)
Mammalia NMT1 35
  • 94.49 (n)
  • 98.59 (a)
NMT1 36
  • 99 (a)
(Mus musculus)
Mammalia Nmt1 35
  • 90.93 (n)
  • 97.38 (a)
Nmt1 16
Nmt1 36
  • 97 (a)
(Pan troglodytes)
Mammalia NMT1 35
  • 99.66 (n)
  • 100 (a)
NMT1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nmt1 35
  • 90.93 (n)
  • 97.38 (a)
(Monodelphis domestica)
Mammalia NMT1 36
  • 90 (a)
(Gallus gallus)
Aves NMT1 35
  • 82.15 (n)
  • 90.3 (a)
NMT1 36
  • 90 (a)
(Anolis carolinensis)
Reptilia NMT1 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nmt2 35
  • 76.38 (n)
  • 83.68 (a)
Str.12909 35
African clawed frog
(Xenopus laevis)
Amphibia nmt1-prov 35
(Danio rerio)
Actinopterygii nmt1a 35
  • 74.97 (n)
  • 83.33 (a)
wufc15d01 35
nmt1a 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmt 37
  • 65 (a)
Nmt 35
  • 63.38 (n)
  • 65.66 (a)
Nmt 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001804 35
  • 65.11 (n)
  • 67.57 (a)
(Caenorhabditis elegans)
Secernentea T17E9.2a 37
  • 57 (a)
T17E9.2b 37
  • 57 (a)
nmt-1 36
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMT1 36
  • 41 (a)
NMT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NMT1 35
  • 59.21 (n)
  • 55.23 (a)
(Oryza sativa)
Liliopsida Os.15143 35
Os01g0708100 35
  • 62.23 (n)
  • 56.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8123 36
  • 56 (a)
Species with no ortholog for NMT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMT1 Gene

Gene Tree for NMT1 (if available)
Gene Tree for NMT1 (if available)

Paralogs for NMT1 Gene

Paralogs for NMT1 Gene

(2) SIMAP similar genes for NMT1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NMT1: view

Variants for NMT1 Gene

Sequence variations from dbSNP and Humsavar for NMT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3087878 - 45,081,693(-) TTTTT(G/T)TTTCT reference, missense
rs12723 -- 45,108,686(+) GCCTT(C/T)TGATG utr-variant-3-prime
rs1005136 -- 45,086,878(+) TTCTT(G/T)CCAAC intron-variant
rs724329 -- 45,106,363(-) AATGA(A/G)GTCTG utr-variant-3-prime
rs1053733 -- 45,105,660(+) ATTCT(A/G)GATAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NMT1 Gene

Variant ID Type Subtype PubMed ID
nsv833457 CNV Loss 17160897
nsv527788 CNV Loss 19592680
dgv3178n71 CNV Loss 21882294
nsv908297 CNV Loss 21882294
dgv3179n71 CNV Loss 21882294
nsv908300 CNV Loss 21882294

Variation tolerance for NMT1 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NMT1 Gene

Disorders for NMT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NMT1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
gallbladder cancer
  • gallbladder ca
- elite association - COSMIC cancer census association via MalaCards
Search NMT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NMT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NMT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMT1 Gene

Publications for NMT1 Gene

  1. Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae. (PMID: 1570339) Duronio R.J. … Gordon J.I. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23 67
  2. N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef. (PMID: 18089753) Seaton K.E. … Smith C.D. (J. Gen. Virol. 2008) 3 23
  3. Elevated N-myristoyltransferase activity and expression in oral squamous cell carcinoma. (PMID: 17549352) Shrivastav A. … Sharma R.K. (Oncol. Rep. 2007) 3 23
  4. N-myristoyltransferase: a potential novel diagnostic marker for colon cancer. (PMID: 18021392) Shrivastav A. … Sharma R.K. (J Transl Med 2007) 3 23
  5. N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system. (PMID: 16530191) Selvakumar P. … Sharma R.K. (FEBS Lett. 2006) 3 23

Products for NMT1 Gene

Sources for NMT1 Gene