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NMT1 Gene

protein-coding   GIFtS: 67
GCID: GC17P043139

N-Myristoyltransferase 1

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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Myristoyltransferase 11 2     alternative1
NMT2 3 5     Long Form1
Myristoyl-CoA:Protein N-Myristoyltransferase 12 3     Myristoyl-CoA:Protein N-Myristoyltransferase1
Peptide N-Myristoyltransferase 12 3     Short Form NMT-S1
Type I N-Myristoyltransferase2 3     Alternative, Short Form NMT-S2
NMT 12 3     Glycylpeptide N-Tetradecanoyltransferase 12
EC 2.3.1.973 8     Long Form, NMT-L2
NMT-L1     

External Ids:    HGNC: 78571   Entrez Gene: 48362   Ensembl: ENSG000001364487   OMIM: 1609935   UniProtKB: P304193   

Export aliases for NMT1 gene to outside databases

Previous GC identifers: GC17M042667 GC17M045252 GC17P043149 GC17P043613 GC17P040494 GC17P038903


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NMT1 Gene:
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the
N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC
2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible
and is required for full expression of the biologic activities of several N-myristoylated proteins, including the
alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311)
(Duronio et al., 1992 (PubMed 1570339)).(supplied by OMIM, Nov 2008)

GeneCards Summary for NMT1 Gene:
NMT1 (N-myristoyltransferase 1) is a protein-coding gene. GO annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity. An important paralog of this gene is NMT2.

UniProtKB/Swiss-Prot: NMT1_HUMAN, P30419
Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins

Gene Wiki entry for NMT1 (N-myristoyltransferase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NMT1 gene promoter:
         c-Fos   AP-1   MAZR   IRF-1   CBF-C   CBF-B   CBF-A   Cart-1   c-Jun   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNMT1 promoter sequence
   Search Chromatin IP Primers for NMT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NMT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

NMT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMT1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P043139:  view genomic region     (about GC identifiers)

Start:
43,128,978 bp from pter      End:
43,186,384 bp from pter
Size:
57,407 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NMT1_HUMAN, P30419 (See protein sequence)
Recommended Name: Glycylpeptide N-tetradecanoyltransferase 1  
Size: 496 amino acids; 56806 Da
Sequence caution: Sequence=AAC09294.1; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for NMT1:
1RXT (3D)        3IU1 (3D)        3IU2 (3D)        3IWE (3D)        3JTK (3D)    
Secondary accessions: A8K7C1 Q9UE09
Alternative splicing: 2 isoforms:  P30419-1   P30419-2   

Explore the universe of human proteins at neXtProt for NMT1: NX_P30419

Explore proteomics data for NMT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys94
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NMT1 (P30419) (see all 21)
     KLVGFIS  EFLLWAL  WALRPPG  QDQPVKM 


    See NMT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066565.1  
    ENSEMBL proteins: 
     ENSP00000468424   ENSP00000439263   ENSP00000466777   ENSP00000466827   ENSP00000258960  
    Reactome Protein details: P30419

    NMT1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NMT1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR000903 MyristoylCoA_TrFase
     IPR022678 MyristoylCoA_TrFase_CS
     IPR022676 MyristoylCoA_TrFase_N
     IPR016181 Acyl_CoA_acyltransferase
     IPR022677 MyristoylCoA_TrFase_C

    Graphical View of Domain Structure for InterPro Entry P30419

    ProtoNet protein and cluster: P30419

    1 Blocks protein domain: IPB000903 Myristoyl-CoA:protein N-myristoyltransferase

    UniProtKB/Swiss-Prot: NMT1_HUMAN, P30419
    Similarity: Belongs to the NMT family


    Find genes that share domains with NMT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMT1_HUMAN, P30419
    Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins
    Catalytic activity: Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide

         Enzyme Number (IUBMB): EC 2.3.1.971 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS9506952
    GO:0004379glycylpeptide N-tetradecanoyltransferase activity IEA--
    GO:0019107myristoyltransferase activity ----
         
    Find genes that share ontologies with NMT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NMT1:
     Decreased Tat-dependent transc 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nmt1):
     mortality/aging 

    Find genes that share phenotypes with NMT1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NMT1
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    miRNA
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    miRTarBase miRNAs that target NMT1:
    hsa-mir-193b-3p (MIRT041243), hsa-mir-615-3p (MIRT039990), hsa-mir-744-5p (MIRT037569), hsa-mir-30d-5p (MIRT047822), hsa-mir-23b-3p (MIRT046372), hsa-mir-186-5p (MIRT045083)

    Block miRNA regulation of human, mouse, rat NMT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NMT1 (see all 66):
    hsa-miR-194* hsa-miR-1321 hsa-miR-3938 hsa-miR-374a hsa-miR-3170 hsa-miR-3148 hsa-miR-192* hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Addgene plasmids for NMT1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMT1_HUMAN, P30419: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    plasma membrane4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--
    GO:0015629actin cytoskeleton IDA--
    GO:0030054cell junction IDA--

    Find genes that share ontologies with NMT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NMT1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    2Activation of BH3-only proteins
    Intrinsic Pathway for Apoptosis0.68
    Activation, myristolyation of BID and translocation to mitochondria0.00
    3The phototransduction cascade
    The phototransduction cascade0.51
    Inactivation, recovery and regulation of the phototransduction cascade0.49
    4Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with NMT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for NMT1
        Late Phase of HIV Life Cycle
    Activation, myristolyation of BID and translocation to mitochondria
    Inactivation, recovery and regulation of the phototransduction cascade


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NMT1
    Interactions:

        GeneGlobe Interaction Network for NMT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NMT1 (P304192, 3 ENSP000002589604) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-1795431 I2D: score=2 STRING: ENSP00000269305
    CAPN2P176552, 3, ENSP000002950064MINT-1795337 I2D: score=2 STRING: ENSP00000295006
    FYNP062413, ENSP000003576564I2D: score=3 STRING: ENSP00000357656
    MARCKSP299663, ENSP000003576244I2D: score=3 STRING: ENSP00000357624
    CABP2Q9NPB33, ENSP000002942884I2D: score=2 STRING: ENSP00000294288
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    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006498N-terminal protein lipidation ----
    GO:0006499N-terminal protein myristoylation IEA--
    GO:0006915apoptotic process TAS--
    GO:0007603phototransduction, visible light TAS--

    Find genes that share ontologies with NMT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NMT1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LY 78335Phenylethanolamine-N-methyltransferase inhibitor[39959-66-5]
    Cystamine dihydrochlorideTransglutaminase inhibitor; neuroprotective[56-17-7]
    BMS 303141ATP citrate lyase inhibitor; orally bioavailable[943962-47-8]
    LDN 27219Transglutaminase 2 (TG2) inhibitor; reversible[312946-37-5]
    TunicamycinAntibiotic; GlcNAc phosphotransferase inhibitor[11089-65-9]

    2 HMDB Compounds for NMT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Tetradecanoyl-CoAMyristoyl-CoA (see all 8)3130-72-1--

    1 DrugBank Compound for NMT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for NMT1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myristoyl-coa 94.2 12 9174411 (1), 2197361 (1), 2271666 (1), 17518043 (1) (see all 6)
    myristic acid 89.5 17 2197361 (1), 2271666 (1), 9506952 (1), 11139338 (1) (see all 15)
    2-hydroxymyristic acid 84.4 2 8103677 (1)
    acyl-coa 65.4 15 2026598 (2), 2271666 (2), 1559967 (2), 9174411 (1) (see all 6)
    anti-fungal 46.8 5 9174411 (1), 17518043 (1), 1559967 (1), 9043113 (1)
    fatty acid 40.4 9 2406721 (2), 9174411 (1), 18289097 (1), 1559967 (1) (see all 7)
    amide 24.5 1 9154965 (1)
    methionine 16 2 15336565 (1)
    tyrosine 15.3 6 16998534 (3), 11594778 (2), 15613341 (1)
    adp 14.1 1 9575206 (1)



    Find genes that share compounds with NMT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NMT1 gene: 
    NM_021079.3  

    Unigene Cluster for NMT1:

    N-myristoyltransferase 1
    Hs.532790  [show with all ESTs]
    Unigene Representative Sequence: NM_021079
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592782 ENST00000588975 ENST00000543908 ENST00000585561 ENST00000590114
    ENST00000592654 ENST00000588455 ENST00000590310 ENST00000587014 ENST00000591931
    ENST00000587120 ENST00000587670 ENST00000258960(uc010dac.1 uc002ihz.3 uc010dad.1)

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    hsa-miR-194* hsa-miR-1321 hsa-miR-3938 hsa-miR-374a hsa-miR-3170 hsa-miR-3148 hsa-miR-192* hsa-miR-761
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      QuantiFast Probe-based Assays in human, mouse, rat NMT1

    Additional mRNA sequence: 

    AF020500.1 AF043324.1 AK291936.1 AK303517.1 BC006538.2 BC006569.2 BC007258.2 BC008312.2 
    BC008579.1 BC109226.1 M86707.1 U79285.1 Y17208.1 Y17209.1 

    Selected DOTS entries (see all 26):

    DT.453507  DT.100825424  DT.100716545  DT.100825427  DT.120953431  DT.406748  DT.86841140  DT.120953542 
    DT.120953473  DT.95072967  DT.95072992  DT.100825416  DT.100825417  DT.120953422  DT.120953497  DT.92450584 
    DT.95072972  DT.100825418  DT.100825428  DT.120953553  DT.40121631  DT.87017268  DT.95256377  DT.97829493 

    Selected AceView cDNA sequences (see all 538):

    CD676176 BM148180 CR615980 CF528074 D54523 CK818838 BU077564 AA687510 
    BG163345 BQ955590 BM680605 NM_021079 R94875 AI347632 BX361441 BU156308 
    BQ649760 BU787613 CR607720 BM015875 AF020500 BM459292 BE243747 BM458633 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NMT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCCGTGAT
    NMT1 Expression
    About this image


    NMT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    NMT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NMT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532790

    UniProtKB/Swiss-Prot: NMT1_HUMAN, P30419
    Tissue specificity: Heart, gut, kidney, liver and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NMT1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmt11 , 5 N-myristoyltransferase 11, 5 90.93(n)1
    97.38(a)1
      11 (66.71 cM)5
    181071  NM_008707.31  NP_032733.11 
     1030281905 
    chicken
    (Gallus gallus)
    Aves NMT11 N-myristoyltransferase 1 82.15(n)
    90.3(a)
      419966  XM_418088.4  XP_418088.1 
    lizard
    (Anolis carolinensis)
    Reptilia NMT16
    N-myristoyltransferase 1
    87(a)
    1 ↔ 1
    6(64771979-64791408)
    African clawed frog
    (Xenopus laevis)
    Amphibia nmt1-prov2 N-myristoyltransferase 1 79.62(n)    BC041300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc15d012 Danio rerio cDNA clone IMAGE2601337, partial cds 79.4(n)    BC056805.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nmt1 , 3 N-terminal protein myristoylation
    glycyl-peptide
    more3
    N-myristoyl transferase1
    65(a)3
    63.38(n)1
    65.66(a)1
      66B103
    389091  NM_079245.31  NP_523969.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T17E9.2a3   -- 57(a)
    (best of 2)
      III(6186548-6188081)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NMT1(YLR195C)4 N-myristoyl transferase, catalyzes the cotranslational, more   --   12(543304-541937) 850892  NP_013296.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NMT11 NMT1 59.21(n)
    55.23(a)
      835805  NM_125084.2  NP_568846.1 
    rice
    (Oryza sativa)
    Liliopsida Os.151432 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.59(n)    AK101457.1 


    ENSEMBL Gene Tree for NMT1 (if available)
    TreeFam Gene Tree for NMT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NMT1 gene
    NMT22  
    2 SIMAP similar genes for NMT1 using alignment to 6 protein entries:     NMT1_HUMAN (see all proteins):
    NMT    NMT2

    Find genes that share paralogs with NMT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NMT1 (see all 944)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58205611,2
    C--43140573(-) ttttt-/Tttttt 1 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs42802971,2
    C,F,A,H--43140600(-) TTCCTG/CTGAtt 1 -- int110Minor allele frequency- C:0.21NS EA NA WA 606
    rs1849909211,2
    --43140677(+) CAACAC/GATCTA 1 -- int10--------
    rs1891067851,2
    C--43140725(+) AAAAAC/TGGAAG 1 -- int10--------
    rs1427504211,2
    --43140920(+) CCTTAC/GGTTTG 1 -- int10--------
    rs1461039491,2
    --43140927(+) TTTGTC/GCCCTA 1 -- int10--------
    rs1927457081,2
    --43140943(+) TGTGAA/GTCACT 1 -- int10--------
    rs1131708661,2
    C--43140995(+) GTGGTG/AGCTCA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1427581791,2
    --43141061(+) CAGTTC/TGAGAA 1 -- int10--------
    rs620658351,2
    C,F--43141151(+) CCCAGG/CTACTC 1 -- int12Minor allele frequency- C:0.25NA 4

    HapMap Linkage Disequilibrium report for NMT1 (43128978 - 43186384 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NMT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833457CNV Loss17160897
    nsv527788CNV Loss19592680
    nsv908300CNV Loss21882294
    nsv908297CNV Loss21882294
    dgv3178n71CNV Loss21882294
    dgv3179n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NMT1
    DNA2.0 Custom Variant and Variant Library Synthesis for NMT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 160993    OMIM disorders: --

    3 diseases from the University of Copenhagen DISEASES database for NMT1:
    Patent foramen ovale     Lambert-Eaton myasthenic syndrome     Myasthenia gravis

    Find genes that share disorders with NMT1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NMT1 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gallbladder carcinoma 64.5 12 10813869 (4), 16846646 (1), 12239600 (1), 15756927 (1) (see all 5)
    colon cancer 49.7 10 18021392 (4), 10718634 (1), 15156568 (1), 16600465 (1) (see all 6)
    epithelial tumor 46.1 9 12239600 (1), 15756927 (1), 14633729 (1), 10891381 (1)
    colorectal tumors 32.2 2 12239600 (1), 9281363 (1)
    immunodeficiency 23.3 5 15613341 (1), 1559967 (1), 18089753 (1), 9191015 (1) (see all 5)
    colorectal cancer 10.5 3 18021392 (1), 16846646 (1)
    adenocarcinoma 6.21 10 9281363 (5), 17390089 (1), 16530191 (1), 10891381 (1)
    brain tumors 4.88 6 15756927 (2), 16846646 (1)
    hepatitis b 3.34 2 9191015 (1)
    cancer 2.19 12 16846646 (2), 18021392 (1), 12239600 (1), 16600465 (1) (see all 8)

    Genetic Association Database (GAD): NMT1
    Human Genome Epidemiology (HuGE) Navigator: NMT1 (2 documents)

    Export disorders for NMT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NMT1 gene, integrated from 10 sources (see all 152):
    (articles sorted by number of sources associating them with NMT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae. (PubMed id 1570339)1, 2, 3, 9 Duronio R.J.... Gordon J.I. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. A second mammalian N-myristoyltransferase. (PubMed id 9506952)1, 2, 9 Giang D.K. and Cravatt B.F. (J. Biol. Chem. 1998)
    3. Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction. (PubMed id 9353336)1, 2, 9 Glover C.J.... Felsted R.L. (J. Biol. Chem. 1997)
    4. Characterization of human and rat brain myristoyl-CoA:protein N- myristoyltransferase: evidence for an alternative splice variant of the enzyme. (PubMed id 9677304)1, 2, 9 Mcilhinney R.A.J....Soloviev M. (Biochem. J. 1998)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef. (PubMed id 18089753)1, 9 Seaton K.E. and Smith C.D. (J. Gen. Virol. 2008)
    9. N-myristoyltransferase: a potential novel diagnostic marker for colon cancer. (PubMed id 18021392)1, 9 Shrivastav A....Sharma R.K. (J Transl Med 2007)
    10. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. (PubMed id 16123142)1, 9 Ducker C.E....Smith C.D. (Mol. Cancer Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4836 HGNC: 7857 AceView: NMT1 Ensembl:ENSG00000136448 euGenes: HUgn4836
    ECgene: NMT1 H-InvDB: NMT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NMT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NMT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NMT1 gene:
    Search GeneIP for patents involving NMT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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