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Aliases for NMT1 Gene

Aliases for NMT1 Gene

  • N-Myristoyltransferase 1 2 3
  • NMT 3 4 6
  • Myristoyl-CoA:Protein N-Myristoyltransferase 1 3 4
  • Type I N-Myristoyltransferase 3 4
  • EC 2.3.1.97 4 64
  • Myristoyl-CoA:Protein N-Myristoyltransferase 2
  • Glycylpeptide N-Tetradecanoyltransferase 1 3
  • Peptide N-Myristoyltransferase 1 4
  • Alternative, Short Form NMT-S 3
  • Short Form NMT-S 2
  • Long Form, NMT-L 3
  • Alternative 2
  • Long Form 2
  • NMT-L 2
  • NMT 1 4

External Ids for NMT1 Gene

Summaries for NMT1 Gene

Entrez Gene Summary for NMT1 Gene

  • Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

GeneCards Summary for NMT1 Gene

NMT1 (N-Myristoyltransferase 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity. An important paralog of this gene is NMT2.

UniProtKB/Swiss-Prot for NMT1 Gene

  • Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Gene Wiki entry for NMT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMT1 Gene

Genomics for NMT1 Gene

Genomic Location for NMT1 Gene

Start:
45,051,610 bp from pter
End:
45,109,016 bp from pter
Size:
57,407 bases
Orientation:
Plus strand

Genomic View for NMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMT1 Gene

Regulatory Elements for NMT1 Gene

Proteins for NMT1 Gene

  • Protein details for NMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30419-NMT1_HUMAN
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 1
    Protein Accession:
    P30419
    Secondary Accessions:
    • A8K7C1
    • Q9UE09

    Protein attributes for NMT1 Gene

    Size:
    496 amino acids
    Molecular mass:
    56806 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC09294.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NMT1 Gene

    Alternative splice isoforms for NMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMT1 Gene

Proteomics data for NMT1 Gene at MOPED

Post-translational modifications for NMT1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys94

Other Protein References for NMT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for NMT1 Gene

UniProtKB/Swiss-Prot:

NMT1_HUMAN
Family:
  • Belongs to the NMT family.:
    • P30419
genes like me logo Genes that share domains with NMT1: view

No data available for Gene Families for NMT1 Gene

Function for NMT1 Gene

Molecular function for NMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
UniProtKB/Swiss-Prot Function: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Enzyme Numbers (IUBMB) for NMT1 Gene

Gene Ontology (GO) - Molecular Function for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity IDA 25255805
GO:0019107 myristoyltransferase activity --
genes like me logo Genes that share ontologies with NMT1: view

Phenotypes for NMT1 Gene

MGI mutant phenotypes for NMT1:
inferred from 1 alleles
GenomeRNAi human phenotypes for NMT1:
genes like me logo Genes that share phenotypes with NMT1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NMT1 Gene

Localization for NMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMT1 Gene

Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=Copurifies with ribosomes. {ECO:0000269 PubMed:9353336}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMT1 Gene COMPARTMENTS Subcellular localization image for NMT1 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
plasma membrane 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton IDA --
GO:0019898 extrinsic component of membrane IDA 9506952
genes like me logo Genes that share ontologies with NMT1: view

Pathways for NMT1 Gene

genes like me logo Genes that share pathways with NMT1: view

Pathways by source for NMT1 Gene

Gene Ontology (GO) - Biological Process for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006499 N-terminal protein myristoylation --
GO:0006915 apoptotic process TAS --
GO:0007603 phototransduction, visible light TAS --
GO:0009249 protein lipoylation --
genes like me logo Genes that share ontologies with NMT1: view

Compounds for NMT1 Gene

(5) Tocris Compounds for NMT1 Gene

Compound Action Cas Number
BMS 303141 ATP citrate lyase inhibitor; orally bioavailable [943962-47-8]
Cystamine dihydrochloride Transglutaminase inhibitor; neuroprotective [56-17-7]
LDN 27219 Transglutaminase 2 (TG2) inhibitor; reversible [312946-37-5]
LY 78335 Phenylethanolamine-N-methyltransferase inhibitor [39959-66-5]
Tunicamycin Antibiotic; GlcNAc phosphotransferase inhibitor [11089-65-9]

(2) HMDB Compounds for NMT1 Gene

Compound Synonyms Cas Number PubMed IDs
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
Tetradecanoyl-CoA
  • Myristoyl-CoA
3130-72-1

(1) Drugbank Compounds for NMT1 Gene

(12) Novoseek inferred chemical compound relationships for NMT1 Gene

Compound -log(P) Hits PubMed IDs
myristoyl-coa 94.2 6
myristic acid 89.5 15
2-hydroxymyristic acid 84.4 1
acyl-coa 65.4 9
anti-fungal 46.8 4
genes like me logo Genes that share compounds with NMT1: view

Transcripts for NMT1 Gene

Unigene Clusters for NMT1 Gene

N-myristoyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMT1 Gene

No ASD Table

Relevant External Links for NMT1 Gene

GeneLoc Exon Structure for
NMT1
ECgene alternative splicing isoforms for
NMT1

Expression for NMT1 Gene

mRNA expression in normal human tissues for NMT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMT1 Gene

SOURCE GeneReport for Unigene cluster for NMT1 Gene Hs.532790

mRNA Expression by UniProt/SwissProt for NMT1 Gene

P30419-NMT1_HUMAN
Tissue specificity: Heart, gut, kidney, liver and placenta
genes like me logo Genes that share expressions with NMT1: view

Orthologs for NMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMT1 36
  • 99.66 (n)
  • 100 (a)
NMT1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NMT1 36
  • 93.08 (n)
  • 98.99 (a)
NMT1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMT1 36
  • 94.49 (n)
  • 98.59 (a)
NMT1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmt1 36
  • 90.93 (n)
  • 97.38 (a)
Nmt1 16
Nmt1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMT1 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmt1 36
  • 90.93 (n)
  • 97.38 (a)
chicken
(Gallus gallus)
Aves NMT1 36
  • 82.15 (n)
  • 90.3 (a)
NMT1 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMT1 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nmt1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nmt2 36
  • 76.38 (n)
  • 83.68 (a)
Str.12909 36
zebrafish
(Danio rerio)
Actinopterygii nmt1a 36
  • 74.97 (n)
  • 83.33 (a)
nmt1a 37
  • 80 (a)
OneToOne
wufc15d01 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001804 36
  • 65.11 (n)
  • 67.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nmt 36
  • 63.38 (n)
  • 65.66 (a)
Nmt 37
  • 56 (a)
OneToMany
Nmt 38
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea nmt-1 37
  • 52 (a)
OneToMany
T17E9.2a 38
  • 57 (a)
T17E9.2b 38
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMT1 37
  • 41 (a)
OneToMany
NMT1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons NMT1 36
  • 59.21 (n)
  • 55.23 (a)
rice
(Oryza sativa)
Liliopsida Os.15143 36
Os01g0708100 36
  • 62.23 (n)
  • 56.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8123 37
  • 56 (a)
OneToMany
Species with no ortholog for NMT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMT1 Gene

ENSEMBL:
Gene Tree for NMT1 (if available)
TreeFam:
Gene Tree for NMT1 (if available)

Paralogs for NMT1 Gene

Paralogs for NMT1 Gene

Selected SIMAP similar genes for NMT1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NMT1: view

Variants for NMT1 Gene

Sequence variations from dbSNP and Humsavar for NMT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12723 -- 45,108,686(+) GCCTT(C/T)TGATG utr-variant-3-prime
rs724329 -- 45,106,363(-) AATGA(A/G)GTCTG utr-variant-3-prime
rs875750 -- 45,088,016(+) AAGTT(A/T)GAGAA intron-variant
rs877598 -- 45,099,264(-) TGCTC(G/T)CCAGC intron-variant
rs877599 -- 45,099,254(-) CCTCC(C/T)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMT1 Gene

Variant ID Type Subtype PubMed ID
nsv833457 CNV Loss 17160897
nsv527788 CNV Loss 19592680
dgv3178n71 CNV Loss 21882294
nsv908297 CNV Loss 21882294
dgv3179n71 CNV Loss 21882294
nsv908300 CNV Loss 21882294

Relevant External Links for NMT1 Gene

HapMap Linkage Disequilibrium report
NMT1

Disorders for NMT1 Gene

(3) University of Copenhagen DISEASES for NMT1 Gene

(13) Novoseek inferred disease relationships for NMT1 Gene

Disease -log(P) Hits PubMed IDs
gallbladder carcinoma 64.5 8
colon cancer 49.7 9
epithelial tumor 46.1 4
colorectal tumors 32.2 2
immunodeficiency 23.3 5

Relevant External Links for NMT1

Genetic Association Database (GAD)
NMT1
Human Genome Epidemiology (HuGE) Navigator
NMT1
genes like me logo Genes that share disorders with NMT1: view

No data available for UniProtKB/Swiss-Prot for NMT1 Gene

Publications for NMT1 Gene

  1. Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae. (PMID: 1570339) Duronio R.J. … Gordon J.I. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23
  2. Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction. (PMID: 9353336) Glover C.J. … Felsted R.L. (J. Biol. Chem. 1997) 3 4 23
  3. Characterization of human and rat brain myristoyl-CoA:protein N- myristoyltransferase: evidence for an alternative splice variant of the enzyme. (PMID: 9677304) Mcilhinney R.A.J. … Soloviev M. (Biochem. J. 1998) 3 4 23
  4. A second mammalian N-myristoyltransferase. (PMID: 9506952) Giang D.K. … Cravatt B.F. (J. Biol. Chem. 1998) 3 4 23
  5. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. (PMID: 16123142) Ducker C.E. … Smith C.D. (Mol. Cancer Res. 2005) 3 23

Products for NMT1 Gene

  • Addgene plasmids for NMT1

Sources for NMT1 Gene

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