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Aliases for NMT1 Gene

Aliases for NMT1 Gene

  • N-Myristoyltransferase 1 2 3 5
  • Myristoyl-CoA:Protein N-Myristoyltransferase 1 3 4
  • Alternative, Short Form NMT-S 2 3
  • Type I N-Myristoyltransferase 3 4
  • Long Form, NMT-L 2 3
  • EC 2.3.1.97 4 61
  • NMT 3 4
  • Myristoyl-CoA:Protein N-Myristoyltransferase 2
  • Glycylpeptide N-Tetradecanoyltransferase 1 3
  • Peptide N-Myristoyltransferase 1 4
  • NMT 1 4

External Ids for NMT1 Gene

Previous GeneCards Identifiers for NMT1 Gene

  • GC17M042667
  • GC17M045252
  • GC17P043149
  • GC17P043613
  • GC17P040494
  • GC17P043139
  • GC17P038903

Summaries for NMT1 Gene

Entrez Gene Summary for NMT1 Gene

  • Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

GeneCards Summary for NMT1 Gene

NMT1 (N-Myristoyltransferase 1) is a Protein Coding gene. Diseases associated with NMT1 include Gallbladder Cancer. Among its related pathways are HIV Life Cycle and Metabolism of fat-soluble vitamins. GO annotations related to this gene include glycylpeptide N-tetradecanoyltransferase activity and myristoyltransferase activity. An important paralog of this gene is NMT2.

UniProtKB/Swiss-Prot for NMT1 Gene

  • Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Tocris Summary for NMT1 Gene

Gene Wiki entry for NMT1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMT1 Gene

Genomics for NMT1 Gene

Regulatory Elements for NMT1 Gene

Enhancers for NMT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G045089 2 FANTOM5 Ensembl ENCODE dbSUPER 16.6 +40.6 40596 4.6 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D SSRP1 DCAKD PLCD3 GFAP NMT1 ACBD4 HEXIM1 GPATCH8 ENSG00000262372 EFTUD2 HIGD1B
GH17G044977 1.5 Ensembl ENCODE dbSUPER 20.9 -71.8 -71811 5.2 PKNOX1 FOXA2 MLX SIN3A YBX1 BRCA1 YY1 ZNF121 ZNF207 FOS LINC02210 GJC1 NMT1 GPATCH8 ENSG00000266918 KIF18B GFAP DCAKD EFTUD2 ADAM11
GH17G045143 1.8 FANTOM5 ENCODE dbSUPER 10.6 +96.3 96337 9.6 MLX CREB3L1 AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 ENSG00000262372 ASB16-AS1 ENSG00000224505 LINC02210 EFTUD2 ENSG00000260793 HEXIM1 DCAKD FMNL1 ENSG00000233175
GH17G045220 1.8 FANTOM5 ENCODE dbSUPER 10.5 +174.7 174718 12.5 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A SLC30A9 ZNF766 CBX5 FMNL1 PLEKHM1 ENSG00000233175 NMT1 LRRC37A4P ENSG00000233483 ARHGAP27 SLC25A39 SPATA32 KANSL1-AS1
GH17G045020 1.5 Ensembl ENCODE dbSUPER 12.2 -30.2 -30186 2.5 ATF1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF143 ZNF207 DCAKD NMT1 C1QL1 GFAP EFTUD2 CCDC103 FAM187A KIF18B HEXIM2 ENSG00000224505
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NMT1 on UCSC Golden Path with GeneCards custom track

Promoters for NMT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094859 -110 1801 HDGF FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for NMT1 Gene

Chromosome:
17
Start:
45,051,610 bp from pter
End:
45,109,016 bp from pter
Size:
57,407 bases
Orientation:
Plus strand

Genomic View for NMT1 Gene

Genes around NMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMT1 Gene

Proteins for NMT1 Gene

  • Protein details for NMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30419-NMT1_HUMAN
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase 1
    Protein Accession:
    P30419
    Secondary Accessions:
    • A8K7C1
    • Q9UE09

    Protein attributes for NMT1 Gene

    Size:
    496 amino acids
    Molecular mass:
    56806 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC09294.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NMT1 Gene

    Alternative splice isoforms for NMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMT1 Gene

Selected DME Specific Peptides for NMT1 Gene

P30419:
  • IIDTFVVE
  • EFLLWAL
  • HKSLKAAYSFYN
  • EPDKDNIRQEPY
  • WALRPPG
  • INFLCVHKKLRSKR
  • QAVYTAGV
  • KDIPVVHQLL
  • QWHCGVRV
  • EVKFSHLSRNMT
  • TDFLSFYTLPST
  • MMEGNGNGHEHCSDCENEED
  • QDQPVKM
  • KLVGFIS
  • GDGNLQYYLYNW
  • TPLLDLMSDAL
  • RNMTMQRTMKLY
  • FRFDYSPEFL
  • YWHRSLNP
  • NYVEDDD
  • FWDTQPVPK

Post-translational modifications for NMT1 Gene

  • Ubiquitination at Lys94
  • Modification sites at PhosphoSitePlus

Other Protein References for NMT1 Gene

Domains & Families for NMT1 Gene

Graphical View of Domain Structure for InterPro Entry

P30419

UniProtKB/Swiss-Prot:

NMT1_HUMAN :
  • Belongs to the NMT family.
Family:
  • Belongs to the NMT family.
genes like me logo Genes that share domains with NMT1: view

No data available for Gene Families for NMT1 Gene

Function for NMT1 Gene

Molecular function for NMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
UniProtKB/Swiss-Prot Function:
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Enzyme Numbers (IUBMB) for NMT1 Gene

Gene Ontology (GO) - Molecular Function for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0019107 myristoyltransferase activity TAS --
genes like me logo Genes that share ontologies with NMT1: view
genes like me logo Genes that share phenotypes with NMT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NMT1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NMT1
  • Applied Biological Materials Clones for NMT1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMT1 Gene

Localization for NMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMT1 Gene

Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=Copurifies with ribosomes. {ECO:0000269 PubMed:9353336}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMT1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
mitochondrion 3
nucleus 3
cytoskeleton 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 9353336
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NMT1: view

Pathways & Interactions for NMT1 Gene

genes like me logo Genes that share pathways with NMT1: view

Pathways by source for NMT1 Gene

Gene Ontology (GO) - Biological Process for NMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006499 N-terminal protein myristoylation TAS --
GO:0018008 N-terminal peptidyl-glycine N-myristoylation IDA 25255805
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS --
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS --
genes like me logo Genes that share ontologies with NMT1: view

No data available for SIGNOR curated interactions for NMT1 Gene

Drugs & Compounds for NMT1 Gene

(12) Drugs for NMT1 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
myristoyl-coa Experimental Pharma Target 0
(1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone Experimental Pharma Target, Target 0
[Cyclohexylethyl]-[[[[4-[2-Methyl-1-Imidazolyl-Butyl]Phenyl]Acetyl]-Seryl]-Lysinyl]-Amine Experimental Pharma Target 0
Tris DBA Pharma 0
Coenzyme A Nutra 0

(9) Additional Compounds for NMT1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
P-3FAX-Neu5Ac
117405-58-0
Perhexiline maleate
6724-53-4

(5) Tocris Compounds for NMT1 Gene

Compound Action Cas Number
(R)-(+)-Etomoxir sodium salt Carnitine palmitoyltransferase I (CPT1) inhibitor 828934-41-4
GGsTop Inhibitor of gamma-glutamyl transpeptidase (GGT) 926281-37-0
LDN 27219 Transglutaminase 2 (TG2) inhibitor; reversible 312946-37-5
P-3FAX-Neu5Ac Sialic acid analog; sialyltransferase inhibitor 117405-58-0
Perhexiline maleate Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor 6724-53-4

(1) ApexBio Compounds for NMT1 Gene

Compound Action Cas Number
Tris DBA 51364-51-3
genes like me logo Genes that share compounds with NMT1: view

Drug Products

Transcripts for NMT1 Gene

Unigene Clusters for NMT1 Gene

N-myristoyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NMT1
  • Applied Biological Materials Clones for NMT1

Alternative Splicing Database (ASD) splice patterns (SP) for NMT1 Gene

No ASD Table

Relevant External Links for NMT1 Gene

GeneLoc Exon Structure for
NMT1
ECgene alternative splicing isoforms for
NMT1

Expression for NMT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMT1 Gene

Protein differential expression in normal tissues from HIPED for NMT1 Gene

This gene is overexpressed in Bone marrow stromal cell (10.7) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NMT1 Gene



Protein tissue co-expression partners for NMT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NMT1 Gene:

NMT1

SOURCE GeneReport for Unigene cluster for NMT1 Gene:

Hs.532790

mRNA Expression by UniProt/SwissProt for NMT1 Gene:

P30419-NMT1_HUMAN
Tissue specificity: Heart, gut, kidney, liver and placenta.

Evidence on tissue expression from TISSUES for NMT1 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Skin(4.5)
  • Muscle(4.4)
  • Eye(3)
  • Lung(2.4)
  • Intestine(2.2)
  • Pancreas(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with NMT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMT1 Gene

Orthologs for NMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMT1 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia NMT1 34 35
  • 94.49 (n)
cow
(Bos Taurus)
Mammalia NMT1 34 35
  • 93.08 (n)
mouse
(Mus musculus)
Mammalia Nmt1 34 16 35
  • 90.93 (n)
rat
(Rattus norvegicus)
Mammalia Nmt1 34
  • 90.93 (n)
oppossum
(Monodelphis domestica)
Mammalia NMT1 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMT1 34 35
  • 82.15 (n)
lizard
(Anolis carolinensis)
Reptilia NMT1 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmt2 34
  • 76.38 (n)
Str.12909 34
African clawed frog
(Xenopus laevis)
Amphibia nmt1-prov 34
zebrafish
(Danio rerio)
Actinopterygii nmt1a 34 35
  • 74.97 (n)
wufc15d01 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001804 34
  • 65.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nmt 36 34 35
  • 63.38 (n)
worm
(Caenorhabditis elegans)
Secernentea T17E9.2a 36
  • 57 (a)
T17E9.2b 36
  • 57 (a)
nmt-1 35
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NMT1 35 37
  • 41 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NMT1 34
  • 59.21 (n)
rice
(Oryza sativa)
Liliopsida Os01g0708100 34
  • 62.23 (n)
Os.15143 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8123 35
  • 56 (a)
OneToMany
Species where no ortholog for NMT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NMT1 Gene

ENSEMBL:
Gene Tree for NMT1 (if available)
TreeFam:
Gene Tree for NMT1 (if available)

Paralogs for NMT1 Gene

Paralogs for NMT1 Gene

(2) SIMAP similar genes for NMT1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NMT1: view

Variants for NMT1 Gene

Sequence variations from dbSNP and Humsavar for NMT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000019596 -- 45,083,098(+) GATCA(C/T)GAGGT intron-variant
rs1000044869 -- 45,090,234(+) AGCCA(C/T)GATCG intron-variant
rs1000090905 -- 45,085,570(+) AGATT(A/G)TATTT intron-variant
rs1000141883 -- 45,066,060(+) CTAAT(A/C)AAATG intron-variant
rs1000165309 -- 45,100,084(+) CAGGT(A/G)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMT1 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv527788 CNV loss 19592680
nsv833457 CNV loss 17160897
nsv953903 CNV deletion 24416366

Variation tolerance for NMT1 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMT1 Gene

Disorders for NMT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NMT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gallbladder cancer
  • gallbladder ca
- elite association - COSMIC cancer census association via MalaCards
Search NMT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NMT1

Genetic Association Database (GAD)
NMT1
Human Genome Epidemiology (HuGE) Navigator
NMT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMT1
genes like me logo Genes that share disorders with NMT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMT1 Gene

Publications for NMT1 Gene

  1. Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae. (PMID: 1570339) Duronio R.J. … Gordon J.I. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 22 64
  2. A second mammalian N-myristoyltransferase. (PMID: 9506952) Giang D.K. … Cravatt B.F. (J. Biol. Chem. 1998) 3 4 22 64
  3. Characterization of human and rat brain myristoyl-CoA:protein N- myristoyltransferase: evidence for an alternative splice variant of the enzyme. (PMID: 9677304) Mcilhinney R.A.J. … Soloviev M. (Biochem. J. 1998) 3 4 22 64
  4. Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction. (PMID: 9353336) Glover C.J. … Felsted R.L. (J. Biol. Chem. 1997) 3 4 22 64
  5. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. (PMID: 25255805) Thinon E. … Tate E.W. (Nat. Commun. 2014) 3 4 64

Products for NMT1 Gene

  • Addgene plasmids for NMT1

Sources for NMT1 Gene

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