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Aliases for NMS Gene

Aliases for NMS Gene

  • Neuromedin S 2 3 5
  • Prepro-NMS 2 3
  • Neuromedin-S 3

External Ids for NMS Gene

Previous GeneCards Identifiers for NMS Gene

  • GC02P100546
  • GC02P101086
  • GC02P094851

Summaries for NMS Gene

Entrez Gene Summary for NMS Gene

  • This gene encodes a member of the neuromedin family of neuropeptides. The encoded preproprotein is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. [provided by RefSeq, May 2016]

GeneCards Summary for NMS Gene

NMS (Neuromedin S) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors.

UniProtKB/Swiss-Prot for NMS Gene

  • Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMS Gene

Genomics for NMS Gene

Regulatory Elements for NMS Gene

Enhancers for NMS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F100478 0.3 FANTOM5 11.3 +8.2 8163 0.4 NMS LOC105373506
GH02F100584 0.3 FANTOM5 2.7 +114.5 114525 0.4 PDCL3 NMS HMGN2P22
GH02F100425 0.8 Ensembl 0.2 -44.3 -44282 0.8 CEBPB LONRF2 LOC129522 NMS
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NMS on UCSC Golden Path with GeneCards custom track

Genomic Location for NMS Gene

Chromosome:
2
Start:
100,470,482 bp from pter
End:
100,483,280 bp from pter
Size:
12,799 bases
Orientation:
Plus strand

Genomic View for NMS Gene

Genes around NMS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMS Gene

Proteins for NMS Gene

  • Protein details for NMS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H8A3-NMS_HUMAN
    Recommended name:
    Neuromedin-S
    Protein Accession:
    Q5H8A3

    Protein attributes for NMS Gene

    Size:
    153 amino acids
    Molecular mass:
    17731 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMS Gene

Post-translational modifications for NMS Gene

No Post-translational modifications

Other Protein References for NMS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NMS Gene

Domains & Families for NMS Gene

Gene Families for NMS Gene

Protein Domains for NMS Gene

Suggested Antigen Peptide Sequences for NMS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5H8A3

UniProtKB/Swiss-Prot:

NMS_HUMAN :
  • Belongs to the NmU family.
Family:
  • Belongs to the NmU family.
genes like me logo Genes that share domains with NMS: view

Function for NMS Gene

Molecular function for NMS Gene

UniProtKB/Swiss-Prot Function:
Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions.

Gene Ontology (GO) - Molecular Function for NMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
genes like me logo Genes that share ontologies with NMS: view

Phenotypes for NMS Gene

genes like me logo Genes that share phenotypes with NMS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NMS

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NMS Gene

Localization for NMS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMS Gene COMPARTMENTS Subcellular localization image for NMS gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NMS: view

Pathways & Interactions for NMS Gene

genes like me logo Genes that share pathways with NMS: view

SIGNOR curated interactions for NMS Gene

Activates:

Gene Ontology (GO) - Biological Process for NMS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IEA,IBA --
GO:0045475 locomotor rhythm IEA,IBA --
genes like me logo Genes that share ontologies with NMS: view

Drugs & Compounds for NMS Gene

(1) Drugs for NMS Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antipsychotic Agents Pharma 2359
genes like me logo Genes that share compounds with NMS: view

Transcripts for NMS Gene

mRNA/cDNA for NMS Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMS Gene

No ASD Table

Relevant External Links for NMS Gene

GeneLoc Exon Structure for
NMS
ECgene alternative splicing isoforms for
NMS

Expression for NMS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NMS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMS Gene

This gene is overexpressed in Brain - Hypothalamus (x34.3) and Brain - Spinal cord (cervical c-1) (x13.1).

Protein differential expression in normal tissues from HIPED for NMS Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NMS Gene



Protein tissue co-expression partners for NMS Gene

NURSA nuclear receptor signaling pathways regulating expression of NMS Gene:

NMS

SOURCE GeneReport for Unigene cluster for NMS Gene:

Hs.567676
genes like me logo Genes that share expression patterns with NMS: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NMS Gene

Orthologs for NMS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMS 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia NMS 34 35
  • 86.44 (n)
cow
(Bos Taurus)
Mammalia NMS 34 35
  • 84.63 (n)
mouse
(Mus musculus)
Mammalia Nms 34 16 35
  • 76.44 (n)
rat
(Rattus norvegicus)
Mammalia NMS 34
  • 75.8 (n)
zebrafish
(Danio rerio)
Actinopterygii -- 34
Species where no ortholog for NMS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMS Gene

ENSEMBL:
Gene Tree for NMS (if available)
TreeFam:
Gene Tree for NMS (if available)

Paralogs for NMS Gene

(1) SIMAP similar genes for NMS Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NMS: view

No data available for Paralogs for NMS Gene

Variants for NMS Gene

Sequence variations from dbSNP and Humsavar for NMS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10166865 -- 100,469,689(+) AATTA(A/G)GGTAA upstream-variant-2KB
rs10203739 -- 100,469,960(+) ATATT(A/G)TACAG upstream-variant-2KB
rs10514779 -- 100,472,521(+) AATAG(C/T)TGTAC intron-variant
rs10616929 -- 100,476,690(+) TCTTC(-/TTC)CCGGC intron-variant, nc-transcript-variant
rs11123833 -- 100,474,680(+) CGTGG(C/T)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMS Gene

Variant ID Type Subtype PubMed ID
nsv1011990 CNV gain 25217958
nsv582531 CNV gain 21841781
nsv582532 CNV gain 21841781
nsv582533 CNV loss 21841781
nsv834312 CNV loss 17160897

Variation tolerance for NMS Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMS Gene

Disorders for NMS Gene

Relevant External Links for NMS

Genetic Association Database (GAD)
NMS
Human Genome Epidemiology (HuGE) Navigator
NMS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMS

No disorders were found for NMS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMS Gene

Publications for NMS Gene

  1. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. (PMID: 15635449) Mori K. … Kangawa K. (EMBO J. 2005) 2 3 4 64
  2. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  3. Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system. (PMID: 18987052) Mitchell J.D. … Davenport A.P. (Cardiovasc. Res. 2009) 3 22 64
  4. Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. (PMID: 19519756) Mitchell J.D. … Davenport A.P. (Br. J. Pharmacol. 2009) 3 22 64
  5. Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms. (PMID: 25741729) Lee I.T. … Yanagisawa M. (Neuron 2015) 3 64

Products for NMS Gene

Sources for NMS Gene

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