NMS Gene
protein-coding GIFtS: 44
GCID: GC02P101086
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neuromedin S
| |
Aliases
for NMS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuromedin S1 2 | | Neuromedin-S1 | | BCS1L5 | | BJS5 | | FLGRACILE5 | | PTD5 |
Export aliases for NMS gene to outside databasesPrevious GC identifers: GC02P100546 GC02P100453 GC02P094851 |
Summaries
for NMS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NMS_HUMAN, Q5H8A3Function: Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions (By similarity)
|
Genomic Views
for NMS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NMS gene promoter:
STAT1 AML1a NRSF form 1 NF-YC CUTL1 Nkx2-5 Cdc5 NRSF form 2 Evi-1 IRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NMS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2NMS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P101086: view genomic region
(about GC identifiers)
Start:
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101,086,944 bp from pter |
End:
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101,099,742 bp from pter |
Size:
|
12,799 bases |
Orientation:
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plus strand |
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Proteins
for NMS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NMS_HUMAN, Q5H8A3 (See
protein sequence)Recommended Name: Neuromedin-S precursor Size: 153 amino acids; 17731 Da
Subcellular location: Secreted (By similarity)Explore the universe of human proteins at neXtProt for NMS: NX_Q5H8A3
NMS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001011717.1
ENSEMBL proteins: ENSP00000366061 Reactome Protein details: Q5H8A3
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- |
NMS for ontologies About GeneDecksing
NMS Antibody Products:
Assay Products for NMS: |
Protein
Domains /
Families
for NMS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NMS for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5H8A3ProtoNet protein and cluster: Q5H8A3 UniProtKB/Swiss-Prot: NMS_HUMAN, Q5H8A3Similarity: Belongs to the NmU family |
Function
for NMS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NMS_HUMAN, Q5H8A3Function: Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NMS (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NMS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for NMS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMS |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001664 | G-protein coupled receptor binding |
-- | -- |
NMS for ontologies About GeneDecksing
|
Pathways & Interactions
for NMS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 
Reactome Pathways for NMS (see all 9)
NMS for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NMS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/247 Interacting proteins for NMS (Q5H8A33 ENSP000003660614) via UniProtKB, MINT, STRING, and/or I2D (see all 247)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006940 | regulation of smooth muscle contraction |
IEA | -- | | GO:0007218 | neuropeptide signaling pathway |
IEA | -- | | GO:0045475 | locomotor rhythm |
-- | -- |
NMS for ontologies About GeneDecksing
|
Drugs & Compounds
for NMS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NMS
Search CenterWatch for drugs/clinical trials and news about NMS
|
Transcripts
for NMS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NMS gene: NM_001011717.1 Unigene Cluster for NMS: Neuromedin S Hs.567676 Unigene Representative Sequence: AB1644641 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000376865(uc002tan.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NMS (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NMS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for NMS | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NMS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMS |
Additional cDNA sequence: AB164464.1 1 DOTS entry: DT.120994010
GeneLoc Exon Structure
|
Expression
for NMS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NMS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTACAGATTC
About this image
See NMS Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.567676
SABiosciences Expression via Pathway-Focused PCR Array including NMS:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NMS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NMS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMS |
Orthologs
for NMS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NMS gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for NMS (if available)
TreeFam Gene Tree for NMS (if available) |
Paralogs
for NMS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NMS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NMS (101086944 - 101099742 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NMS
1 CNV: 4302 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NMS |
|
Disorders
/ Diseases
for NMS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NMS for disorders About GeneDecksing
OMIM gene information: 603647
OMIM disorders: 124000 603358 256000 262000
9  diseases for NMS: About MalaCardsacral lentiginous melanoma mitochondrial complex iii deficiency neuroleptic malignant syndrome bjornstad syndrome
gracile syndrome nodular malignant melanoma anorexia nervosa thymoma
melanoma
Human Genome Epidemiology (HuGE) Navigator: NMS (10 documents)
Export disorders for NMS gene to outside databases
|
Publications
for NMS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NMS gene integrated from 9 sources:
(articles sorted by number of sources associating them with NMS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. (PubMed id 15635449)1, 2, 3 Mori K.... Kangawa K. (2005)
- Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system. (PubMed id 18987052)1, 9 Mitchell J.D....Davenport A.P. (2009)
- Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. (PubMed id 19519756)1, 9 Mitchell J.D....Davenport A.P. (2009)
- Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1 Pinheiro A.P....Woodside D.B. (2010)
- Identification and functional analysis of a novel ligand for G protein-coupled receptor, Neuromedin S. (PubMed id 17870195)1 Miyazato M....Kangawa K. (2008)
- Stable association between G alpha(q) and phospholipase C beta 1 in living cells. (PubMed id 16754659)1 Dowal L....Scarlata S. (2006)
- Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. (PubMed id 10899166)1 Raddatz R....Adham N. (2000)
- Expression of NMS and NMU2R in the pig reproductive a xis during the estrus cycle and the effect of NMS on the reproductive axis in v itro. (PubMed id 19781586)9 Yang G....Liu Y. (2009)
- Structural and functional analogs of the novel mammalian neuropeptide, neuromedin S (NmS), in the dermal venoms of Eurasian bombinid toads. (PubMed id 16682011)9 Chen T....Shaw C. (2006)
- Appetite-modifying actions of pro-neuromedin U-derive d peptides. (PubMed id 19531638)9 Bechtold D.A....Luckman S.M. (2009)
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External Searches for NMS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NMS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NMS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NMS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NMS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NMS gene:
Search GeneIP for patents involving NMS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NMS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NMS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NMS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NMS | | | OriGene Protein Over-expression Lysate for NMS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NMS | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NMS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NMS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NMS | | OriGene Custom Protein Services for NMS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NMS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NMS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMS |
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| | | | Search Tocris compounds for NMS |
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 | | | NMS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMS |
|  |  |  | | | | Search ThermoFisher Antibodies for NMS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMS |
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