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NMRK2 Gene

protein-coding GIFtS: 47
GCID: GC19P003933

Nicotinamide Riboside Kinase 2

(Previous name: integrin beta 1 binding protein 3)
(Previous symbol: ITGB1BP3)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Nicotinamide Riboside Kinase 2¹ ²		MIBP² ³
ITGB1BP3¹ ² ³		NRK2² ³
Muscle-Specific Beta 1 Integrin Binding Protein¹ ²		NRK 2² ³
Integrin Beta-1-Binding Protein 3² ³		RNK 2² ³
Nicotinic Acid Riboside Kinase 2² ³		Integrin Beta 1 Binding Protein 3¹
NmR-K 2² ³		EC 2.7.1.173³
Ribosylnicotinamide Kinase 2² ³		EC 2.7.1.22³
Ribosylnicotinic Acid Kinase 2² ³		Muscle Integrin-Binding Protein³

External Ids:	HGNC: 17871¹	Entrez Gene: 27231²	Ensembl: ENSG00000077009⁷	OMIM: 608705⁵	UniProtKB: Q9NPI5³

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(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NMRK2 Gene:

NMRK2 (nicotinamide riboside kinase 2) is a protein-coding gene. GO annotations related to this gene include ribosylnicotinamide kinase activity. An important paralog of this gene is NMRK1.

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5

Function: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form

nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and

cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of

PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis

Gene Wiki entry for NMRK2 (ITGB1BP3) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9 NT_011295.12 NC_018930.2

Regulatory elements:

Search for regulatory transcription factor binding sites for NMRK2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NMRK2 promoter sequence

Search Chromatin IP Primers for NMRK2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NMRK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

NMRK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMRK2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P003933: view genomic region (about GC identifiers)

Start:	3,933,101 bp from pter	End:	3,942,414 bp from pter
Size:	9,314 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5 (See protein sequence)

Recommended Name: Nicotinamide riboside kinase 2

Size: 230 amino acids; 26046 Da

Subunit: Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5

Sequence caution: Sequence=AAF26711.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

Secondary accessions: Q52M81 Q9NZK3

Explore the universe of human proteins at neXtProt for NMRK2: NX_Q9NPI5

Explore proteomics data for NMRK2 at MOPED

See NMRK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001276046.1 NP_733778.1

ENSEMBL proteins:

ENSP00000168977 ENSP00000471436 ENSP00000472581 ENSP00000468935

NMRK2 Human Recombinant Protein Products:

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	antibodies-online proteins for NMRK2 (5 products)
	antibodies-online peptides for NMRK2

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	antibodies-online kits for NMRK2 (4 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:

IPR027417 P-loop_NTPase

IPR026681 NRK

Graphical View of Domain Structure for InterPro Entry Q9NPI5

ProtoNet protein and cluster: Q9NPI5

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5

Similarity: Belongs to the uridine kinase family. NRK subfamily

Find genes that share domains with NMRK2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: NRK2_HUMAN, Q9NPI5

Function: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form

nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and

cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of

PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis

Catalytic activity: ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide

Catalytic activity: ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide

Biophysicochemical properties: Kinetic parameters: KM=0.19 mM for nicotinamide riboside (with ATP as cosubstrate);

KM=30 mM for nicotinamide riboside (with GTP as cosubstrate); KM=0.11 mM for tiazofurin (with ATP as

cosubstrate); KM=0.063 mM for nicotinic acid riboside (with ATP as cosubstrate); KM=1.3 mM for uridine (with ATP

as cosubstrate);

Induction: Down-regulated during myoblast differentiation (By similarity)

Enzyme Numbers (IUBMB): EC 2.7.1.22¹ EC 2.7.1.173¹

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12809483
GO:0005524	ATP binding	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0050262	ribosylnicotinamide kinase activity	IEA	--

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Phenotypes:
1 MGI phenotypic allele

for Nmrk2 (no phenotypes)

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Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for NMRK2

miRNA Products:		miRTarBase miRNAs that target NMRK2: hsa-mir-181a-5p (MIRT025069), hsa-mir-26b-5p (MIRT028997)

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NMRK2 About

See pathways by source

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SuperPath

Contained pathways About

Nicotinate and nicotinamide metabolism

Nicotinate and nicotinamide metabolism

0.43

NAD metabolism

0.43

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Pathways by source See SuperPaths
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for NMRK2

NAD metabolism

1 Kegg Pathway (Kegg details for NMRK2):

Nicotinate and nicotinamide metabolism

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5

Pathway: Cofactor biosynthesis; NAD(+) biosynthesis

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for NMRK2
Interactions:

Search GeneGlobe Interaction Network for NMRK2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NMRK2 (Q9NPI5^{1, 2, 3} ENSP00000168977⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SAT1	P21673²^,³	MINT-63583 I2D: score=5
IGF2	P01344²^,³	MINT-8258577 I2D: score=2
LRP12	Q9Y561¹^,³, ENSP00000276654⁴	EBI-514059,EBI-296693 I2D: score=2 STRING: ENSP00000276654
ST7	Q9NRC1³, ENSP00000265437⁴	I2D: score=1 STRING: ENSP00000265437
ITGB1	P05556³, ENSP00000364094⁴	I2D: score=1 STRING: ENSP00000364094

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009435	NAD biosynthetic process	IEA	--
GO:0019359	nicotinamide nucleotide biosynthetic process	--	--
GO:0045662	negative regulation of myoblast differentiation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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Browse Tocris compounds for NMRK2 (NRK2)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NMRK2 gene (3 alternative transcripts):

NM_014446.1 NM_001289117.1 NM_170678.2

Unigene Cluster for NMRK2:

Nicotinamide riboside kinase 2

Hs.135458 [show with all ESTs]

Unigene Representative Sequence: NM_170678

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000168977(uc002lyz.4 uc010xia.2) ENST00000599576 ENST00000593949

ENST00000597889

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Additional mRNA sequence:

AF190819.1 AK001663.1 AK022514.1 AL365377.1 AY611481.1 BC093637.1 BC101575.1 BC143329.1

3 DOTS entries:

DT.430745 DT.97836673 DT.100748647

Selected AceView cDNA sequences (see all 34):

AL365377 AY611481 BM669267 AJ346155 BX280576 AU154323 AJ346366 AK022514

Z28616 AK001663 AU132878 BM717225 AI081312 NM_170678 AA722785 AA722719

AJ707133 AJ346367 F19405 AI160896 AI674785 AF190819 Z24874 C04002

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NMRK2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8
SP1:
SP2:															-		-
SP3:					-		-								-		-		-

ECgene alternative splicing isoforms for NMRK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NMRK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

NMRK2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 4 entries
hIPS1

NULL (Uncategorized)
Mesenchymal Progenitor Cells - Passage 2

Heart (Cardiovascular System)

NMRK2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NMRK2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.135458

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5

Tissue specificity: Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at

protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NMRK2 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nmrk2^{1 , 5}	integrin beta 1 binding protein 3⁵ nicotinamide riboside kinase 2¹	83.25(n)¹ 85.13(a)¹		10 (39.72 cM)⁵ 69564¹ NM_027120.2¹ NP_081396.1¹ 81198170⁵
chicken (Gallus gallus)	Aves	LOC100858798¹	nicotinamide riboside kinase 2-like	79.32(n) 74.68(a)		100858798 XM_003642852.2 XP_003642900.2
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	58(a)	1 → many	GL343747.1(201044-209983)
African clawed frog (Xenopus laevis)	Amphibia	BX853350.1²	--	74.51(n)		BX853350.1
zebrafish (Danio rerio)	Actinopterygii	BC050155.1²	--	76.31(n)		64674 BC050155.1
fruit fly (Drosophila melanogaster)	Insecta	CG12016⁶	--	22(a)	1 → many	3L(3319555-3322489)

ENSEMBL Gene Tree for NMRK2 (if available)
TreeFam Gene Tree for NMRK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NMRK2 gene

NMRK1²

2 SIMAP similar genes for NMRK2 using alignment to 3 protein entries: NRK2_HUMAN (see all proteins):

ITGB1BP3 NMRK1

Find genes that share paralogs with NMRK2 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200114937^1,2	C	untested¹	3942105(+)	`GTCCCA/GAGAGG`	2	Q R	mis¹		0	--	--	--	--
rs4807535^1,2	C,F,H	--	3931177(+)	`CTTCCC/TGCCGG`	1	--	us2k¹ trp³		25		NS EA NA WA CSA	2350
rs181251291^1,2		--	3931241(+)	`GGGCAC/TGTCAC`	1	--	us2k¹		0	--	--	--	--
rs28497308^1,2	C,F,H	--	3931269(+)	`GGCCAC/TGTGCC`	1	--	us2k¹ tfbs³		12		NS NA WA	1552
rs183526669^1,2		--	3931279(+)	`CCCACC/GAAGAG`	1	--	us2k¹		0	--	--	--	--
rs375609797^1,2	C	--	3931433(+)	`ACTGC-/TTTTTC`	1	--	us2k¹		0	--	--	--	--
rs188065609^1,2	C	--	3931545(+)	`TTGGTC/TGGGCG`	1	--	us2k¹		0	--	--	--	--
rs141257491^1,2		--	3931644(+)	`TGTAAA/CAAGAC`	1	--	us2k¹		0	--	--	--	--
rs10404963^1,2	C,H	--	3931794(+)	`TTCCCA/CCTTTT`	1	--	us2k¹		5		NS EA NA	416
rs116987495^1,2	C,F	--	3931946(+)	`GAGAGG/ACGTCA`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for NMRK2 (3933101 - 3942414 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for NMRK2: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NMRK2

DNA2.0 Custom Variant and Variant Library Synthesis for NMRK2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608705 OMIM disorders: --

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Export disorders for NMRK2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NMRK2 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with NMRK2)

Utopia: connect your pdf to the dynamic
world of online information

A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation. (PubMed id 10613898)^{1, 2, 3, 9} Li J.... Wu C. (J. Cell Biol. 1999)
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PubMed id 15137942)^{1, 2, 3} Bieganowski P. and Brenner C. (Cell 2004)
The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. (PubMed id 12941630)^{1, 2, 9} Li J.... Wu C. (Dev. Biol. 2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (Sci Signal 2011)
Nicotinamide riboside kinase structures reveal new pathways to NAD+. (PubMed id 17914902)² Tempel W.... Brenner C. (PLoS Biol. 2007)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (Cell 2005)
ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. (PubMed id 12809483)¹ Battle M.A.... McCormick J.J. (Biochemistry 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27231	HGNC: 17871	AceView: ITGB1BP3	Ensembl:ENSG00000077009	euGenes: HUgn27231
ECgene: NMRK2	Kegg: 27231	H-InvDB: NMRK2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NMRK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NMRK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NMRK2 gene:
Search GeneIP for patents involving NMRK2

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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