Aliases for NMRK2 Gene
Aliases for NMRK2 Gene
External Ids for NMRK2 Gene
- HGNC: 17871
- Entrez Gene: 27231
- Ensembl: ENSG00000077009
- OMIM: 608705
- UniProtKB: Q9NPI5
Previous HGNC Symbols for NMRK2 Gene
- ITGB1BP3
Summaries for NMRK2 Gene
GeneCards Summary for NMRK2 Gene
NMRK2 (Nicotinamide Riboside Kinase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include ribosylnicotinamide kinase activity. An important paralog of this gene is NMRK1.
UniProtKB/Swiss-Prot for NMRK2 Gene
-
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMRK2 Gene
Genomics for NMRK2 Gene
GeneHancer (GH) Regulatory Elements for NMRK2 Gene
Regulatory Element Products
Genomic Locations for NMRK2 Gene
- chr19:3,933,103-3,942,416
- (GRCh38/hg38)
- Size:
- 9,314 bases
- Orientation:
- Plus strand
- chr19:3,933,101-3,942,414
- (GRCh37/hg19)
Genomic View for NMRK2 Gene
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC


RefSeq DNA sequence for NMRK2 Gene
Proteins for NMRK2 Gene
-
Protein details for NMRK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NPI5-NRK2_HUMAN
- Recommended name:
- Nicotinamide riboside kinase 2
- Protein Accession:
- Q9NPI5
- B7ZKR3
- Q52M81
- Q9NZK3
Protein attributes for NMRK2 Gene
- Size:
- 230 amino acids
- Molecular mass:
- 26046 Da
- Quaternary structure:
-
- Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5.
- SequenceCaution:
-
- Sequence=AAF26711.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
Protein Expression for NMRK2 Gene
Post-translational modifications for NMRK2 Gene
Other Protein References for NMRK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NMRK2
- Novus Biologicals Antibodies for NMRK2
- Invitrogen Antibodies for NMRK2
- GeneTex NMRK2 antibody for NMRK2
Protein Products
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-
Abcam proteins for NMRK2
Assay Products
No data available for DME Specific Peptides for NMRK2 Gene
Domains & Families for NMRK2 Gene
Gene Families for NMRK2 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for NMRK2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NMRK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NPI5- Family:
-
- Belongs to the uridine kinase family. NRK subfamily.
Function for NMRK2 Gene
Molecular function for NMRK2 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.19 mM for nicotinamide riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=30 mM for nicotinamide riboside (with GTP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=0.11 mM for tiazofurin (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=0.063 mM for nicotinic acid riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=1.3 mM for uridine (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902};
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide.
- UniProtKB/Swiss-Prot Function:
- Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated during myoblast differentiation.
Enzyme Numbers (IUBMB) for NMRK2 Gene
Phenotypes From GWAS Catalog for NMRK2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 12809483 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016301 | kinase activity | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for NMRK2 Gene
- MGI mutant phenotypes for NMRK2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NMRK2:
Animal Models for NMRK2 Gene
- MGI Knock Outs for NMRK2:
-
- Nmrk2 tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for NMRK2
- genomics-online: gRNA clones - Search results for available ITGB1BP3 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NMRK2
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miRNA for NMRK2 Gene
- miRTarBase miRNAs that target NMRK2
miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
- Sino Biological Human cDNA Clone for NMRK2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NMRK2
- genomics-online: cdna clones - Search results for available ITGB1BP3 gene related products
- orf clones - Search results for available ITGB1BP3 gene related products
- Applied Biological Materials Clones for NMRK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NMRK2
-
ViGene Biosciences adenoviral particle packaged cDNA for NMRK2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NMRK2 gene
-
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No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMRK2 Gene
Localization for NMRK2 Gene
- Nucleoplasm (4)
- Vesicles (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IDA | -- |
GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for NMRK2 Gene
Pathways & Interactions for NMRK2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | NAD metabolism |
.42
|
|
2 | Metabolism |
.37
|
|
3 | Metabolism of water-soluble vitamins and cofactors |
Pathways by source for NMRK2 Gene
4 Reactome pathways for NMRK2 Gene
2 KEGG pathways for NMRK2 Gene
1 GeneGo (Thomson Reuters) pathway for NMRK2 Gene
UniProtKB/Swiss-Prot Q9NPI5-NRK2_HUMAN
- Pathway: Cofactor biosynthesis; NAD(+) biosynthesis.
Interacting Proteins for NMRK2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0009435 | NAD biosynthetic process | IEA | -- |
GO:0016310 | phosphorylation | IEA | -- |
GO:0019363 | pyridine nucleotide biosynthetic process | IEA | -- |
GO:0019674 | NAD metabolic process | TAS | -- |
GO:0045662 | negative regulation of myoblast differentiation | IEA | -- |
No data available for SIGNOR curated interactions for NMRK2 Gene
Drugs & Compounds for NMRK2 Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
beta-nicotinamide D-ribonucleotide |
|
|
||||
Nicotinamide riboside |
|
1341-23-7 |
|
|||
nicotinate beta-D-ribonucleotide |
|
|
|
|||
Nicotinate D-ribonucleoside |
|
|
Transcripts for NMRK2 Gene
mRNA/cDNA for NMRK2 Gene
- (6) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NMRK2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NMRK2
- genomics-online: gRNA clones - Search results for available ITGB1BP3 gene related products
- Applied Biological Materials CRISPR for NMRK2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NMRK2
- GenScript: Design CRISPR guide RNA sequences for NMRK2
miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available ITGB1BP3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NMRK2 gene
Clone Products
- Sino Biological Human cDNA Clone for NMRK2
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- VectorBuilder custom plasmid, inducible vectors for NMRK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NMRK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NMRK2
- genomics-online: cdna clones - Search results for available ITGB1BP3 gene related products
- orf clones - Search results for available ITGB1BP3 gene related products
- Applied Biological Materials Clones for NMRK2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||
SP3: | - | - | - | - | - |
Expression for NMRK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- NULL (Uncategorized)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for NMRK2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NMRK2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NMRK2 Gene:
NMRK2SOURCE GeneReport for Unigene cluster for NMRK2 Gene:
Hs.135458mRNA Expression by UniProt/SwissProt for NMRK2 Gene:
Q9NPI5-NRK2_HUMANEvidence on tissue expression from TISSUES for NMRK2 Gene
- Heart(4.6)
- Liver(4)
- Muscle(2.9)
- Urine(2.6)
Primer Products
-
OriGene qPCR primer pairs for NMRK2
- genomics-online: primer clones - Search results for available ITGB1BP3 gene related products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMRK2 Gene
Orthologs for NMRK2 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NMRK2 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | ITGB1BP3 34 33 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Nmrk2 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Nmrk2 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | NMRK2 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | NMRK2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | LOC100858798 33 |
|
||
NMRK2 34 |
|
OneToOne | |||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6863 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | LOC100538223 33 |
|
||
nmrk2 34 |
|
OneToMany | |||
mibp 34 |
|
OneToMany | |||
-- 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.717 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG12016 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for NMRK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NMRK2 Gene
(2) SIMAP similar genes for NMRK2 Gene using alignment to 3 proteins:
Variants for NMRK2 Gene
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000064884 | -- | 3,932,402(+) | C/A | upstream_transcript_variant | |
rs1000587207 | -- | 3,935,244(+) | C/T | intron_variant | |
rs1000882643 | -- | 3,931,721(+) | G/T | upstream_transcript_variant | |
rs1000912792 | -- | 3,937,203(+) | G/C | intron_variant | |
rs1001092269 | -- | 3,936,312(+) | G/A | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv6228n54 | CNV | loss | 21841781 |
dgv6229n54 | CNV | gain+loss | 21841781 |
dgv6230n54 | CNV | loss | 21841781 |
esv26716 | CNV | loss | 19812545 |
esv2673167 | CNV | deletion | 23128226 |
esv2717977 | CNV | deletion | 23290073 |
esv3643483 | CNV | loss | 21293372 |
esv3643484 | CNV | loss | 21293372 |
nsv1134745 | CNV | deletion | 24896259 |
nsv833715 | CNV | loss | 17160897 |
Additional Variant Information for NMRK2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NMRK2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMRK2 Gene
Disorders for NMRK2 Gene
Additional Disease Information for NMRK2
No disorders were found for NMRK2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMRK2 Gene
Publications for NMRK2 Gene
- A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation. (PMID: 10613898) Li J … Wu C (The Journal of cell biology 1999) 2 3 4 22 58
- Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PMID: 15137942) Bieganowski P … Brenner C (Cell 2004) 2 3 4 58
- The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. (PMID: 12941630) Li J … Wu C (Developmental biology 2003) 3 4 22 58
- Nicotinamide riboside kinase structures reveal new pathways to NAD+. (PMID: 17914902) Tempel W … Brenner C (PLoS biology 2007) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for NMRK2 Gene
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- Invitrogen Antibodies for NMRK2
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- VectorBuilder custom plasmid, inducible vectors for NMRK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NMRK2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for NMRK2
- antibodies-online: Search results for 26 available ITGB1BP3 Antibodies ranked by validation data
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- GeneTex NMRK2 antibody for NMRK2
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- ViGene Biosciences adenoviral particle packaged cDNA for NMRK2 gene
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- genomics-online: cdna clones - Search results for available ITGB1BP3 gene related products
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Sources for NMRK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
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