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NMRK2 Gene

protein-coding   GIFtS: 47
GCID: GC19P003933

Nicotinamide Riboside Kinase 2

(Previous name: integrin beta 1 binding protein 3)
(Previous symbol: ITGB1BP3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nicotinamide Riboside Kinase 21 2     MIBP2 3
ITGB1BP31 2 3     NRK22 3
Muscle-Specific Beta 1 Integrin Binding Protein1 2     NRK 22 3
Integrin Beta-1-Binding Protein 32 3     RNK 22 3
Nicotinic Acid Riboside Kinase 22 3     Integrin Beta 1 Binding Protein 31
NmR-K 22 3     EC 2.7.1.1733
Ribosylnicotinamide Kinase 22 3     EC 2.7.1.223
Ribosylnicotinic Acid Kinase 22 3     Muscle Integrin-Binding Protein3

External Ids:    HGNC: 178711   Entrez Gene: 272312   Ensembl: ENSG000000770097   OMIM: 6087055   UniProtKB: Q9NPI53   

Export aliases for NMRK2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NMRK2 Gene:
NMRK2 (nicotinamide riboside kinase 2) is a protein-coding gene. GO annotations related to this gene include ribosylnicotinamide kinase activity. An important paralog of this gene is NMRK1.

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5
Function: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form
nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and
cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of
PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis

Gene Wiki entry for NMRK2 (ITGB1BP3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NMRK2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NMRK2 promoter sequence
   Search Chromatin IP Primers for NMRK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NMRK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

NMRK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMRK2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003933:  view genomic region     (about GC identifiers)

Start:
3,933,101 bp from pter      End:
3,942,414 bp from pter
Size:
9,314 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5 (See protein sequence)
Recommended Name: Nicotinamide riboside kinase 2  
Size: 230 amino acids; 26046 Da
Subunit: Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5
Sequence caution: Sequence=AAF26711.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q52M81 Q9NZK3

Explore the universe of human proteins at neXtProt for NMRK2: NX_Q9NPI5

Explore proteomics data for NMRK2 at MOPED


See NMRK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001276046.1  NP_733778.1  

ENSEMBL proteins: 
 ENSP00000168977   ENSP00000471436   ENSP00000472581   ENSP00000468935  

NMRK2 Human Recombinant Protein Products:

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Novus Biologicals NMRK2 Proteins
Novus Biologicals NMRK2 Lysates
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antibodies-online proteins for NMRK2 (5 products) 

 
antibodies-online peptides for NMRK2

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antibodies-online antibodies for NMRK2 (12 products) 

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antibodies-online kits for NMRK2 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR027417 P-loop_NTPase
 IPR026681 NRK

Graphical View of Domain Structure for InterPro Entry Q9NPI5

ProtoNet protein and cluster: Q9NPI5

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5
Similarity: Belongs to the uridine kinase family. NRK subfamily


Find genes that share domains with NMRK2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NRK2_HUMAN, Q9NPI5
Function: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form
nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and
cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of
PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis
Catalytic activity: ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide
Catalytic activity: ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide
Biophysicochemical properties: Kinetic parameters: KM=0.19 mM for nicotinamide riboside (with ATP as cosubstrate);
KM=30 mM for nicotinamide riboside (with GTP as cosubstrate); KM=0.11 mM for tiazofurin (with ATP as
cosubstrate); KM=0.063 mM for nicotinic acid riboside (with ATP as cosubstrate); KM=1.3 mM for uridine (with ATP
as cosubstrate);
Induction: Down-regulated during myoblast differentiation (By similarity)

     Enzyme Numbers (IUBMB): EC 2.7.1.221 EC 2.7.1.1731

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI12809483
GO:0005524ATP binding IEA--
GO:0046872metal ion binding IEA--
GO:0050262ribosylnicotinamide kinase activity IEA--
     
Find genes that share ontologies with NMRK2           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Nmrk2 (no phenotypes)

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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for NMRK2

miRNA
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miRTarBase miRNAs that target NMRK2:
hsa-mir-181a-5p (MIRT025069), hsa-mir-26b-5p (MIRT028997)

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Addgene plasmids for NMRK2 

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NMRK2 About    
See pathways by source

SuperPathContained pathways About
1Nicotinate and nicotinamide metabolism
Nicotinate and nicotinamide metabolism0.43
NAD metabolism0.43


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Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for NMRK2
    NAD metabolism


1 Kegg Pathway  (Kegg details for NMRK2):
    Nicotinate and nicotinamide metabolism

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5
Pathway: Cofactor biosynthesis; NAD(+) biosynthesis

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NMRK2
Interactions:

    Search GeneGlobe Interaction Network for NMRK2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NMRK2 (Q9NPI51, 2, 3 ENSP000001689774) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

InteractantInteraction Details
GeneCardExternal ID(s)
SAT1P216732, 3MINT-63583 I2D: score=5 
IGF2P013442, 3MINT-8258577 I2D: score=2 
LRP12Q9Y5611, 3, ENSP000002766544EBI-514059,EBI-296693 I2D: score=2 STRING: ENSP00000276654
ST7Q9NRC13, ENSP000002654374I2D: score=1 STRING: ENSP00000265437
ITGB1P055563, ENSP000003640944I2D: score=1 STRING: ENSP00000364094
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0009435NAD biosynthetic process IEA--
GO:0019359nicotinamide nucleotide biosynthetic process ----
GO:0045662negative regulation of myoblast differentiation IEA--

Find genes that share ontologies with NMRK2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NMRK2 (NRK2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NMRK2 gene (3 alternative transcripts): 
NM_014446.1  NM_001289117.1  NM_170678.2  

Unigene Cluster for NMRK2:

Nicotinamide riboside kinase 2
Hs.135458  [show with all ESTs]
Unigene Representative Sequence: NM_170678
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000168977(uc002lyz.4 uc010xia.2) ENST00000599576 ENST00000593949
ENST00000597889
miRNA
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Addgene plasmids for NMRK2 
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for NMRK2
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  QuantiFast Probe-based Assays in human, mouse, rat NMRK2

Additional mRNA sequence: 

AF190819.1 AK001663.1 AK022514.1 AL365377.1 AY611481.1 BC093637.1 BC101575.1 BC143329.1 

3 DOTS entries:

DT.430745  DT.97836673  DT.100748647 

Selected AceView cDNA sequences (see all 34):

AL365377 AY611481 BM669267 AJ346155 BX280576 AU154323 AJ346366 AK022514 
Z28616 AK001663 AU132878 BM717225 AI081312 NM_170678 AA722785 AA722719 
AJ707133 AJ346367 F19405 AI160896 AI674785 AF190819 Z24874 C04002 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NMRK2    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1:                                                                  
SP2:                                            -     -               
SP3:              -     -                       -     -     -         


ECgene alternative splicing isoforms for NMRK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NMRK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NMRK2 Expression
About this image


NMRK2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
         hIPS1
 
 NULL (Uncategorized)
         Mesenchymal Progenitor Cells - Passage 2
 
 Heart (Cardiovascular System)
NMRK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NMRK2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.135458

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5
Tissue specificity: Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at
protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NMRK2 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nmrk21 , 5 integrin beta 1 binding protein 35
nicotinamide riboside kinase 21
83.25(n)1
85.13(a)1
  10 (39.72 cM)5
695641  NM_027120.21  NP_081396.11 
 811981705 
chicken
(Gallus gallus)
Aves LOC1008587981 nicotinamide riboside kinase 2-like 79.32(n)
74.68(a)
  100858798  XM_003642852.2  XP_003642900.2 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
58(a)
1 → many
GL343747.1(201044-209983)
African clawed frog
(Xenopus laevis)
Amphibia BX853350.12   -- 74.51(n)    BX853350.1 
zebrafish
(Danio rerio)
Actinopterygii BC050155.12   -- 76.31(n)   64674  BC050155.1 
fruit fly
(Drosophila melanogaster)
Insecta CG120166
--
22(a)
1 → many
3L(3319555-3322489)


ENSEMBL Gene Tree for NMRK2 (if available)
TreeFam Gene Tree for NMRK2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NMRK2 gene
NMRK12  
2 SIMAP similar genes for NMRK2 using alignment to 3 protein entries:     NRK2_HUMAN (see all proteins):
ITGB1BP3    NMRK1

Find genes that share paralogs with NMRK2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NMRK2 (see all 371)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2001149371,2
Cuntested13942105(+) GTCCCA/GAGAGG 2 Q R mis10--------
rs48075351,2
C,F,H--3931177(+) CTTCCC/TGCCGG 1 -- us2k1 trp325Minor allele frequency- T:0.15NS EA NA WA CSA 2350
rs1812512911,2
--3931241(+) GGGCAC/TGTCAC 1 -- us2k10--------
rs284973081,2
C,F,H--3931269(+) GGCCAC/TGTGCC 1 -- us2k1 tfbs312Minor allele frequency- T:0.08NS NA WA 1552
rs1835266691,2
--3931279(+) CCCACC/GAAGAG 1 -- us2k10--------
rs3756097971,2
C--3931433(+) ACTGC-/TTTTTC 1 -- us2k10--------
rs1880656091,2
C--3931545(+) TTGGTC/TGGGCG 1 -- us2k10--------
rs1412574911,2
--3931644(+) TGTAAA/CAAGAC 1 -- us2k10--------
rs104049631,2
C,H--3931794(+) TTCCCA/CCTTTT 1 -- us2k15Minor allele frequency- C:0.00NS EA NA 416
rs1169874951,2
C,F--3931946(+) GAGAGG/ACGTCA 1 -- us2k11Minor allele frequency- A:0.06EA 120

HapMap Linkage Disequilibrium report for NMRK2 (3933101 - 3942414 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NMRK2: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NMRK2
DNA2.0 Custom Variant and Variant Library Synthesis for NMRK2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608705    OMIM disorders: --


Find genes that share disorders with NMRK2           About GenesLikeMe


Export disorders for NMRK2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NMRK2 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with NMRK2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation. (PubMed id 10613898)1, 2, 3, 9 Li J.... Wu C. (J. Cell Biol. 1999)
  2. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PubMed id 15137942)1, 2, 3 Bieganowski P. and Brenner C. (Cell 2004)
  3. The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. (PubMed id 12941630)1, 2, 9 Li J.... Wu C. (Dev. Biol. 2003)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
  8. Nicotinamide riboside kinase structures reveal new pathways to NAD+. (PubMed id 17914902)2 Tempel W.... Brenner C. (PLoS Biol. 2007)
  9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
  10. ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. (PubMed id 12809483)1 Battle M.A.... McCormick J.J. (Biochemistry 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27231 HGNC: 17871 AceView: ITGB1BP3 Ensembl:ENSG00000077009 euGenes: HUgn27231
ECgene: NMRK2 Kegg: 27231 H-InvDB: NMRK2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NMRK2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NMRK2 gene:
Search GeneIP for patents involving NMRK2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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