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NMRK2 Gene(Protein Coding)

Nicotinamide Riboside Kinase 2

GCID:
GC19P003933
GIFtS:
50
Genes Participants
UDN Logo

Aliases for NMRK2 Gene

Aliases for NMRK2 Gene

  • Nicotinamide Riboside Kinase 2 2 3 2 5
  • Muscle-Specific Beta 1 Integrin Binding Protein 2 3
  • Integrin Beta-1-Binding Protein 3 3 4
  • Nicotinic Acid Riboside Kinase 2 3 4
  • Ribosylnicotinic Acid Kinase 2 3 4
  • Ribosylnicotinamide Kinase 2 3 4
  • ITGB1BP3 3 4
  • NmR-K 2 3 4
  • NRK 2 3 4
  • RNK 2 3 4
  • NRK2 3 4
  • MIBP 3 4
  • Integrin Beta 1 Binding Protein 3 2
  • Muscle Integrin-Binding Protein 4
  • EC 2.7.1.173 4
  • EC 2.7.1.22 4

External Ids for NMRK2 Gene

Previous HGNC Symbols for NMRK2 Gene

  • ITGB1BP3

Summaries for NMRK2 Gene

GeneCards Summary for NMRK2 Gene

NMRK2 (Nicotinamide Riboside Kinase 2) is a Protein Coding gene. Among its related pathways are Metabolism and NAD metabolism. GO annotations related to this gene include ribosylnicotinamide kinase activity. An important paralog of this gene is NMRK1.

UniProtKB/Swiss-Prot for NMRK2 Gene

  • Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.

Gene Wiki entry for NMRK2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMRK2 Gene

Genomics for NMRK2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for NMRK2 Gene

Enhancers for NMRK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NMRK2 on UCSC Golden Path with GeneCards custom track

Promoters for NMRK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NMRK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NMRK2 Gene

Chromosome:
19
Start:
3,933,103 bp from pter
End:
3,942,416 bp from pter
Size:
9,314 bases
Orientation:
Plus strand

Genomic View for NMRK2 Gene

Genes around NMRK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMRK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMRK2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NMRK2 Gene

Proteins for NMRK2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NMRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI5-NRK2_HUMAN
    Recommended name:
    Nicotinamide riboside kinase 2
    Protein Accession:
    Q9NPI5
    Secondary Accessions:
    • B7ZKR3
    • Q52M81
    • Q9NZK3

    Protein attributes for NMRK2 Gene

    Size:
    230 amino acids
    Molecular mass:
    26046 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5.
    SequenceCaution:
    • Sequence=AAF26711.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for NMRK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMRK2 Gene

Proteomics data for NMRK2 Gene at MOPED

Protein Expression for NMRK2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NMRK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NMRK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NMRK2 Gene

Domains & Families for NMRK2 Gene

Protein Domains for NMRK2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NMRK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPI5

UniProtKB/Swiss-Prot:

NRK2_HUMAN :
  • Belongs to the uridine kinase family. NRK subfamily.
Family:
  • Belongs to the uridine kinase family. NRK subfamily.
genes like me logo Genes that share domains with NMRK2: view

No data available for Gene Families for NMRK2 Gene

Function for NMRK2 Gene

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  2. CRISPR
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  4. Inhibitory RNA
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  7. Flow Cytometry

Molecular function for NMRK2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.19 mM for nicotinamide riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=30 mM for nicotinamide riboside (with GTP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=0.11 mM for tiazofurin (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=0.063 mM for nicotinic acid riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=1.3 mM for uridine (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide.
UniProtKB/Swiss-Prot Function:
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.
UniProtKB/Swiss-Prot Induction:
Down-regulated during myoblast differentiation.

Enzyme Numbers (IUBMB) for NMRK2 Gene

Gene Ontology (GO) - Molecular Function for NMRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12809483
GO:0050262 ribosylnicotinamide kinase activity IEA --
genes like me logo Genes that share ontologies with NMRK2: view

Phenotypes for NMRK2 Gene

MGI mutant phenotypes for NMRK2:
inferred from 1 alleles
GenomeRNAi human phenotypes for NMRK2:
genes like me logo Genes that share phenotypes with NMRK2: view

Animal Models for NMRK2 Gene

MGI Knock Outs for NMRK2:

Animal Model Products

CRISPR Products

miRNA for NMRK2 Gene

miRTarBase miRNAs that target NMRK2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMRK2 Gene

Localization for NMRK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NMRK2 Gene COMPARTMENTS Subcellular localization image for NMRK2 gene
Compartment Confidence
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NMRK2 Gene

Pathways & Interactions for NMRK2 Gene

genes like me logo Genes that share pathways with NMRK2: view

Pathways by source for NMRK2 Gene

1 GeneGo (Thomson Reuters) pathway for NMRK2 Gene

UniProtKB/Swiss-Prot Q9NPI5-NRK2_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis.

Gene Ontology (GO) - Biological Process for NMRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009435 NAD biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with NMRK2: view

No data available for SIGNOR curated interactions for NMRK2 Gene

Drugs & Compounds for NMRK2 Gene

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  1. Drug

(2) Drugs for NMRK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
NAD Pharma Full agonist, Agonist 0

(6) Additional Compounds for NMRK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
beta-nicotinamide D-ribonucleotide
Nicotinamide riboside
  • 1-(beta-D-Ribofuranosyl)nicotinamide
  • 1-b-D-Ribosyl-3-Pyridinecarboxamide
  • 1-beta-D-Ribosyl-3-Pyridinecarboxamide
  • 1-beta-delta-Ribosyl-3-Pyridinecarboxamide
  • 3-(Aminocarbonyl)-1-beta-D-ribofuranosyl-Pyridinium
 1341-23-7
nicotinate beta-D-ribonucleotide
Nicotinate D-ribonucleoside
  • D-Ribosylnicotinate
  • Nicotinate riboside
  • Nicotinic acid ribose
  • Nicotinic acid riboside
  • Ribosylnicotinate
genes like me logo Genes that share compounds with NMRK2: view

Transcripts for NMRK2 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
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mRNA/cDNA for NMRK2 Gene

(5) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NMRK2 Gene

Nicotinamide riboside kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMRK2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1:
SP2: - -
SP3: - - - - -

Relevant External Links for NMRK2 Gene

GeneLoc Exon Structure for
NMRK2
ECgene alternative splicing isoforms for
NMRK2

Expression for NMRK2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for NMRK2 Gene

mRNA expression in normal human tissues for NMRK2 Gene
mRNA expression by BioGPS for NMRK2 GenemRNA expression by GTEx for NMRK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMRK2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x24.3), Heart - Left Ventricle (x20.8), and Muscle - Skeletal (x6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NMRK2 Gene



SOURCE GeneReport for Unigene cluster for NMRK2 Gene Hs.135458

mRNA Expression by UniProt/SwissProt for NMRK2 Gene

Q9NPI5-NRK2_HUMAN
Tissue specificity: Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta.
genes like me logo Genes that share expression patterns with NMRK2: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for NMRK2 Gene

Orthologs for NMRK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NMRK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia ITGB1BP3 35
  • 90.43 (n)
  • 90.26 (a)
ITGB1BP3 36
  • 91 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Nmrk2 35
  • 83.25 (n)
  • 85.13 (a)
Nmrk2 16
Nmrk2 36
  • 85 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia NMRK2 35
  • 98.94 (n)
  • 99.1 (a)
NMRK2 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Nmrk2 35
  • 83.25 (n)
  • 84.1 (a)
oppossum
(Monodelphis domestica)
 Mammalia NMRK2 36
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia NMRK2 36
  • 70 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LOC100858798 35
  • 79.32 (n)
  • 74.68 (a)
NMRK2 36
  • 47 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 58 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia Str.6863 35
zebrafish
(Danio rerio)
 Actinopterygii -- 35
mibp 35
  • 67.01 (n)
  • 67.01 (a)
mibp 36
  • 64 (a)
 OneToMany
nmrk2 36
  • 65 (a)
 OneToMany
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.717 35
fruit fly
(Drosophila melanogaster)
 Insecta CG12016 36
  • 22 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 33 (a)
 OneToMany
Species with no ortholog for NMRK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMRK2 Gene

ENSEMBL:
Gene Tree for NMRK2 (if available)
TreeFam:
Gene Tree for NMRK2 (if available)

Paralogs for NMRK2 Gene

Paralogs for NMRK2 Gene

(2) SIMAP similar genes for NMRK2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NMRK2: view

Variants for NMRK2 Gene

Sequence variations from dbSNP and Humsavar for NMRK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs16992131 - 3,942,112(+) GAGAG(A/G)AGCTC nc-transcript-variant, reference, missense
rs12976629 -- 3,942,862(+) atcag(C/G)ccact downstream-variant-500B
rs12978161 -- 3,937,465(+) CCCCC(A/G)GGGTC intron-variant
rs12978913 -- 3,937,714(+) GCAAT(A/G)CCCGC intron-variant
rs7508648 -- 3,938,844(+) ttttt(G/T)ttttg intron-variant

Variation tolerance for NMRK2 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NMRK2 Gene

Disorders for NMRK2 Gene

Relevant External Links for NMRK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMRK2

No disorders were found for NMRK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMRK2 Gene

Publications for NMRK2 Gene

  1. A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation. (PMID: 10613898) Li J. … Wu C. (J. Cell Biol. 1999) 2 3 4 23 67
  2. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PMID: 15137942) Bieganowski P. … Brenner C. (Cell 2004) 2 3
  3. The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. (PMID: 12941630) Li J. … Wu C. (Dev. Biol. 2003) 3 23
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

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