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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NMRK2 Gene

protein-coding   GIFtS: 49
GCID: GC19P003933

Nicotinamide Riboside Kinase 2

(Previous name: integrin beta 1 binding protein 3)
(Previous symbol: ITGB1BP3)
  Search for NMRK2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nicotinamide Riboside Kinase 21 2     Ribosylnicotinamide Kinase 22 3
ITGB1BP31 2 3     Ribosylnicotinic Acid Kinase 22 3
Integrin Beta 1 Binding Protein 31 2     MIBP2 3
Muscle-Specific Beta 1 Integrin Binding Protein1 2     NRK22 3
Integrin Beta-1-Binding Protein 32 3     NRK 22 3
Muscle Integrin-Binding Protein2 3     RNK 22 3
Nicotinic Acid Riboside Kinase 22 3     EC 2.7.1.1733
NmR-K 22 3     EC 2.7.1.223

External Ids:    HGNC: 178711   Entrez Gene: 272312   Ensembl: ENSG000000770097   OMIM: 6087055   UniProtKB: Q9NPI53   

Export aliases for NMRK2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NMRK2 Gene: 
NMRK2 (nicotinamide riboside kinase 2) is a protein-coding gene. Among its related super-pathways are NAD metabolism and NAD salvage pathway III. GO annotations related to this gene include ribosylnicotinamide kinase activity and metal ion binding. An important paralog of this gene is NMRK1.

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5
Function: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form
nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and
cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of
PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis

Gene Wiki entry for NMRK2 (ITGB1BP3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NMRK2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NMRK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NMRK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMRK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

NMRK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMRK2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P003933:  view genomic region     (about GC identifiers)

Start:
3,933,101 bp from pter      End:
3,942,414 bp from pter
Size:
9,314 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5 (See protein sequence)
Recommended Name: Nicotinamide riboside kinase 2  
Size: 230 amino acids; 26046 Da
Subunit: Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5
Sequence caution: Sequence=AAF26711.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q52M81 Q9NZK3

Explore the universe of human proteins at neXtProt for NMRK2: NX_Q9NPI5

Explore proteomics data for NMRK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPI5

  • NMRK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NMRK2 Protein Expression
    REFSEQ proteins: NP_733778.1  
    ENSEMBL proteins: 
     ENSP00000168977   ENSP00000471436   ENSP00000472581   ENSP00000468935  

    Human Recombinant Protein Products for NMRK2: 
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    Novus Biologicals NMRK2 Proteins
    Novus Biologicals NMRK2 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    NMRK2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q9NPI5

    ProtoNet protein and cluster: Q9NPI5

    UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5
    Similarity: Belongs to the uridine kinase family. NRK subfamily


    NMRK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRK2_HUMAN, Q9NPI5
    Function: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form
    nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and
    cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of
    PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis
    Catalytic activity: ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide
    Catalytic activity: ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide
    Biophysicochemical properties: Kinetic parameters: KM=0.19 mM for nicotinamide riboside (with ATP as cosubstrate);
    KM=30 mM for nicotinamide riboside (with GTP as cosubstrate); KM=0.11 mM for tiazofurin (with ATP as
    cosubstrate); KM=0.063 mM for nicotinic acid riboside (with ATP as cosubstrate); KM=1.3 mM for uridine (with ATP
    as cosubstrate);
    Induction: Down-regulated during myoblast differentiation (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.1.221 EC 2.7.1.1731

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12809483
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0050262ribosylnicotinamide kinase activity IEA--
         
    NMRK2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Nmrk2 (no phenotypes)

    NMRK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nmrk2tm1(KOMP)Vlcg for NMRK2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NMRK2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NMRK2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NMRK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1NAD metabolism
    NAD metabolism0.43
    Nicotinate and nicotinamide metabolism0.43
    2Nicotinate metabolism
    NAD salvage pathway III0.50
    NAD salvage pathway II0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NMRK2
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for NMRK2
        NAD metabolism

    2 BioSystems Pathways for NMRK2
        NAD salvage pathway III
    NAD salvage pathway II


    1         Kegg Pathway  (Kegg details for NMRK2):
        Nicotinate and nicotinamide metabolism

    UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5
    Pathway: Cofactor biosynthesis; NAD(+) biosynthesis


    NMRK2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NMRK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/13 Interacting proteins for NMRK2 (Q9NPI51, 2, 3 ENSP000001689774) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF2P013442, 3, ENSP000003382974MINT-8258577 I2D: score=2 STRING: ENSP00000338297
    SAT1P216732, 3MINT-63583 I2D: score=5 
    LRP12Q9Y5611, 3, ENSP000002766544EBI-514059,EBI-296693 I2D: score=2 STRING: ENSP00000276654
    ST7Q9NRC13, ENSP000002654374I2D: score=1 STRING: ENSP00000265437
    ITGB1P055563, ENSP000003640944I2D: score=1 STRING: ENSP00000364094
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009435NAD biosynthetic process IEA--
    GO:0045662negative regulation of myoblast differentiation IEA--

    NMRK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NMRK2 (NRK2)

    Search CenterWatch for drugs/clinical trials and news about NMRK2 / NRK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NMRK2 gene (2 alternative transcripts): 
    NM_014446.1  NM_170678.2  

    Unigene Cluster for NMRK2:

    Nicotinamide riboside kinase 2
    Hs.135458  [show with all ESTs]
    Unigene Representative Sequence: NM_170678
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000168977(uc002lyz.4 uc010xia.2) ENST00000599576 ENST00000593949
    ENST00000597889
    miRNA
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    Additional mRNA sequence: 

    AF190819.1 AK001663.1 AK022514.1 AL365377.1 AY611481.1 BC093637.1 BC101575.1 BC143329.1 

    3 DOTS entries:

    DT.430745  DT.97836673  DT.100748647 

    24/34 AceView cDNA sequences (see all 34):

    AY611481 AJ346155 AU154323 BM669267 BX280576 AL365377 AU132878 Z28616 
    AK001663 NM_170678 BM717225 AA722785 AJ346366 AA722719 AK022514 AI081312 
    AI160896 AJ707133 F19405 NM_014446 AF190819 Z24874 C04002 AI674785 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NMRK2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
    SP1:                                                                  
    SP2:                                            -     -               
    SP3:              -     -                       -     -     -         


    ECgene alternative splicing isoforms for NMRK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NMRK2 expression in normal human tissues (normalized intensities)      NMRK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NMRK2 Expression
    About this image


    NMRK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             hIPS1
     
     Endoderm (Gastrulation Derivatives)
             Definitive endoderm-like cells ( Generation of mesendoderm and definitive endoderm...
     
     Heart (Cardiovascular System)

    See NMRK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NMRK2

    SOURCE GeneReport for Unigene cluster: Hs.135458

    UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5
    Tissue specificity: Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at
    protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NMRK2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmrk21 , 5 integrin beta 1 binding protein 35
    nicotinamide riboside kinase 21
    83.25(n)1
    85.13(a)1
      10 (39.72 cM)5
    695641  NM_027120.21  NP_081396.11 
     811981705 
    chicken
    (Gallus gallus)
    Aves LOC1008587981 nicotinamide riboside kinase 2-like 79.11(n)
    74.68(a)
      100858798  XM_003642852.1  XP_003642900.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BX853350.12   -- 74.51(n)    BX853350.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC050155.12   -- 76.31(n)   64674  BC050155.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120166
    --
    20(a)
    1 → many
    3L(3319555-3322489)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NRK16
    Nicotinamide riboside kinase, catalyzes the phosph...
    17(a)
    1 → many
    XIV(381480-382202)


    ENSEMBL Gene Tree for NMRK2 (if available)
    TreeFam Gene Tree for NMRK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NMRK2 gene
    NMRK12  
    2 SIMAP similar genes for NMRK2 using alignment to 3 protein entries:     NRK2_HUMAN (see all proteins):
    ITGB1BP3    NMRK1

    NMRK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/371 SNPs in NMRK2 are shown (see all 371)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2001149371,2
    Cuntested13942105(+) GTCCCA/GAGAGG 2 Q R mis10--------
    rs48075351,2
    C,F,H--3931177(+) CTTCCC/TGCCGG 1 -- us2k1 trp325Minor allele frequency- T:0.15NS EA NA WA CSA 2350
    rs1812512911,2
    --3931241(+) GGGCAC/TGTCAC 1 -- us2k10--------
    rs284973081,2
    C,F,H--3931269(+) GGCCAC/TGTGCC 1 -- us2k1 tfbs312Minor allele frequency- T:0.08NS NA WA 1552
    rs1835266691,2
    --3931279(+) CCCACC/GAAGAG 1 -- us2k10--------
    rs3756097971,2
    C--3931433(+) ACTGC-/TTTTTC 1 -- us2k10--------
    rs1880656091,2
    C--3931545(+) TTGGTC/TGGGCG 1 -- us2k10--------
    rs1412574911,2
    --3931644(+) TGTAAA/CAAGAC 1 -- us2k10--------
    rs104049631,2
    C,H--3931794(+) TTCCCA/CCTTTT 1 -- us2k15Minor allele frequency- C:0.00NS EA NA 416
    rs1169874951,2
    C,F--3931946(+) GAGAGG/ACGTCA 1 -- us2k11Minor allele frequency- A:0.06EA 120

    HapMap Linkage Disequilibrium report for NMRK2 (3933101 - 3942414 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NMRK2: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NMRK2 for disorders           About MalaCards
    OMIM gene information: 608705    OMIM disorders: --


    NMRK2 for disorders           About GeneDecksing


    Export disorders for NMRK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NMRK2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with NMRK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation. (PubMed id 10613898)1, 2, 3, 9 Li J.... Wu C. (1999)
    2. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PubMed id 15137942)1, 2, 3 Bieganowski P. and Brenner C. (2004)
    3. The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. (PubMed id 12941630)1, 2, 9 Li J.... Wu C. (2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Nicotinamide riboside kinase structures reveal new pathways to NAD+. (PubMed id 17914902)2 Tempel W.... Brenner C. (2007)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    10. ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. (PubMed id 12809483)1 Battle M.A.... McCormick J.J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27231 HGNC: 17871 AceView: ITGB1BP3 Ensembl:ENSG00000077009 euGenes: HUgn27231
    ECgene: NMRK2 Kegg: 27231 H-InvDB: NMRK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NMRK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NMRK2 gene:
    Search GeneIP for patents involving NMRK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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