Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NMRK2 Gene

protein-coding GIFtS: 49
GCID: GC19P003933

Nicotinamide Riboside Kinase 2

(Previous name: integrin beta 1 binding protein 3)
(Previous symbol: ITGB1BP3)

Search for NMRK2
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Nicotinamide Riboside Kinase 2¹ ²		Ribosylnicotinamide Kinase 2² ³
ITGB1BP3¹ ² ³		Ribosylnicotinic Acid Kinase 2² ³
Integrin Beta 1 Binding Protein 3¹ ²		MIBP² ³
Muscle-Specific Beta 1 Integrin Binding Protein¹ ²		NRK2² ³
Integrin Beta-1-Binding Protein 3² ³		NRK 2² ³
Muscle Integrin-Binding Protein² ³		RNK 2² ³
Nicotinic Acid Riboside Kinase 2² ³		EC 2.7.1.173³
NmR-K 2² ³		EC 2.7.1.22³

External Ids:	HGNC: 17871¹	Entrez Gene: 27231²	Ensembl: ENSG00000077009⁷	OMIM: 608705⁵	UniProtKB: Q9NPI5³

Export aliases for NMRK2 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NMRK2 Gene:

NMRK2 (nicotinamide riboside kinase 2) is a protein-coding gene. Among its related super-pathways are NAD metabolism and NAD salvage pathway III. GO annotations related to this gene include ribosylnicotinamide kinase activity and metal ion binding. An important paralog of this gene is NMRK1.

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5

Function: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form

nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and

cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of

PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis

Gene Wiki entry for NMRK2 (ITGB1BP3) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NT_011255.14 NC_018930.2

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for NMRK2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NMRK2 promoter sequence

Search SABiosciences Chromatin IP Primers for NMRK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMRK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

NMRK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMRK2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P003933: view genomic region (about GC identifiers)

Start:	3,933,101 bp from pter	End:	3,942,414 bp from pter
Size:	9,314 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5 (See protein sequence)

Recommended Name: Nicotinamide riboside kinase 2

Size: 230 amino acids; 26046 Da

Subunit: Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5

Sequence caution: Sequence=AAF26711.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;

Secondary accessions: Q52M81 Q9NZK3

Explore the universe of human proteins at neXtProt for NMRK2: NX_Q9NPI5

Explore proteomics data for NMRK2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9NPI5

NMRK2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_733778.1

ENSEMBL proteins:

ENSP00000168977 ENSP00000471436 ENSP00000472581 ENSP00000468935

Human Recombinant Protein Products for NMRK2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for NMRK2
	GenScript Custom Purified and Recombinant Proteins Services for NMRK2
	Novus Biologicals NMRK2 Proteins Novus Biologicals NMRK2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

NMRK2 for ontologies About GeneDecksing

NMRK2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for NMRK2
	GenScript Custom Superior Antibodies Services for NMRK2
	Novus Biologicals NMRK2 Antibodies
	Abcam antibodies for NMRK2
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for NMRK2
	LSBio Antibodies in human, mouse, rat for NMRK2

Assay Products for NMRK2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for NMRK2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NMRK2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR027417 P-loop_NTPase

Graphical View of Domain Structure for InterPro Entry Q9NPI5

ProtoNet protein and cluster: Q9NPI5

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5

Similarity: Belongs to the uridine kinase family. NRK subfamily

NMRK2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NRK2_HUMAN, Q9NPI5

Function: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form

nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and

cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of

PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis

Catalytic activity: ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide

Catalytic activity: ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide

Biophysicochemical properties: Kinetic parameters: KM=0.19 mM for nicotinamide riboside (with ATP as cosubstrate);

KM=30 mM for nicotinamide riboside (with GTP as cosubstrate); KM=0.11 mM for tiazofurin (with ATP as

cosubstrate); KM=0.063 mM for nicotinic acid riboside (with ATP as cosubstrate); KM=1.3 mM for uridine (with ATP

as cosubstrate);

Induction: Down-regulated during myoblast differentiation (By similarity)

Enzyme Numbers (IUBMB): EC 2.7.1.22¹ EC 2.7.1.173¹

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12809483
GO:0005524	ATP binding	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0050262	ribosylnicotinamide kinase activity	IEA	--

NMRK2 for ontologies About GeneDecksing

Phenotypes:
1 MGI phenotypic allele

for Nmrk2 (no phenotypes)

NMRK2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Nmrk2^{tm1(KOMP)Vlcg} for NMRK2

inGenious Targeting Laboratory - Custom generated mouse model solutions for NMRK2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NMRK2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NMRK2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NMRK2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMRK2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NMRK2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for NMRK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMRK2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NMRK2
			Sirion Biotech Customized adenovirus for overexpression of NMRK2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for NMRK2 (see all 4) OriGene ORF clones in mouse, rat for NMRK2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for NMRK2
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMRK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMRK2
		Sirion Biotech Customized lentivirus for stable overexpression of NMRK2 Customized lentivirus expression plasmids for stable overexpression of NMRK2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NMRK2
		Search LifeMap BioReagents cell lines for NMRK2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMRK2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for NMRK2 About

See pathways by source

SuperPath

Contained pathways About

NAD metabolism

NAD metabolism

0.43

Nicotinate and nicotinamide metabolism

0.43

Nicotinate metabolism

NAD salvage pathway III

0.50

NAD salvage pathway II

0.42

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for NMRK2

NAD metabolism

1 GeneGo (Thomson Reuters) Pathway for NMRK2

NAD metabolism

2 BioSystems Pathways for NMRK2

	NAD salvage pathway III
	NAD salvage pathway II

1 Kegg Pathway (Kegg details for NMRK2):

Nicotinate and nicotinamide metabolism

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5

Pathway: Cofactor biosynthesis; NAD(+) biosynthesis

NMRK2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NMRK2

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/13 Interacting proteins for NMRK2 (Q9NPI5^{1, 2, 3} ENSP00000168977⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGF2	P01344²^,³, ENSP00000338297⁴	MINT-8258577 I2D: score=2 STRING: ENSP00000338297
SAT1	P21673²^,³	MINT-63583 I2D: score=5
LRP12	Q9Y561¹^,³, ENSP00000276654⁴	EBI-514059,EBI-296693 I2D: score=2 STRING: ENSP00000276654
ST7	Q9NRC1³, ENSP00000265437⁴	I2D: score=1 STRING: ENSP00000265437
ITGB1	P05556³, ENSP00000364094⁴	I2D: score=1 STRING: ENSP00000364094

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009435	NAD biosynthetic process	IEA	--
GO:0045662	negative regulation of myoblast differentiation	IEA	--

NMRK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NMRK2 (NRK2)

Search CenterWatch for drugs/clinical trials and news about NMRK2 / NRK2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NMRK2 gene (2 alternative transcripts):

NM_014446.1 NM_170678.2

Unigene Cluster for NMRK2:

Nicotinamide riboside kinase 2

Hs.135458 [show with all ESTs]

Unigene Representative Sequence: NM_170678

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000168977(uc002lyz.4 uc010xia.2) ENST00000599576 ENST00000593949

ENST00000597889

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NMRK2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NMRK2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for NMRK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMRK2

Clone Products:		OriGene clones in human, mouse for NMRK2 (see all 4) OriGene ORF clones in mouse, rat for NMRK2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for NMRK2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NMRK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMRK2
		Sirion Biotech Customized lentivirus for stable overexpression of NMRK2 Customized lentivirus expression plasmids for stable overexpression of NMRK2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for NMRK2
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat NMRK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMRK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMRK2

Additional mRNA sequence:

AF190819.1 AK001663.1 AK022514.1 AL365377.1 AY611481.1 BC093637.1 BC101575.1 BC143329.1

3 DOTS entries:

DT.430745 DT.97836673 DT.100748647

24/34 AceView cDNA sequences (see all 34):

AY611481 AJ346155 AU154323 BM669267 BX280576 AL365377 AU132878 Z28616

AK001663 NM_170678 BM717225 AA722785 AJ346366 AA722719 AK022514 AI081312

AI160896 AJ707133 F19405 NM_014446 AF190819 Z24874 C04002 AI674785

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for NMRK2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8
SP1:
SP2:															-		-
SP3:					-		-								-		-		-

ECgene alternative splicing isoforms for NMRK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NMRK2 expression in normal human tissues (normalized intensities) NMRK2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

NMRK2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/3 selected tissues (see all 3) fully expand


Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 3 entries
hIPS1

Endoderm (Gastrulation Derivatives)
Definitive endoderm-like cells ( Generation of mesendoderm and definitive endoderm...

Heart (Cardiovascular System)

See NMRK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NMRK2

SOURCE GeneReport for Unigene cluster: Hs.135458

UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5

Tissue specificity: Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at

protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta

SABiosciences Custom PCR Arrays for NMRK2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for NMRK2
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat NMRK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMRK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMRK2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMRK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for NMRK2 gene from 6/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nmrk2^{1 , 5}	integrin beta 1 binding protein 3⁵ nicotinamide riboside kinase 2¹	83.25(n)¹ 85.13(a)¹		10 (39.72 cM)⁵ 69564¹ NM_027120.2¹ NP_081396.1¹ 81198170⁵
chicken (Gallus gallus)	Aves	LOC100858798¹	nicotinamide riboside kinase 2-like	79.11(n) 74.68(a)		100858798 XM_003642852.1 XP_003642900.1
African clawed frog (Xenopus laevis)	Amphibia	BX853350.1²	--	74.51(n)		BX853350.1
zebrafish (Danio rerio)	Actinopterygii	BC050155.1²	--	76.31(n)		64674 BC050155.1
fruit fly (Drosophila melanogaster)	Insecta	CG12016⁶	--	20(a)	1 → many	3L(3319555-3322489)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NRK1⁶	Nicotinamide riboside kinase, catalyzes the phosph...	17(a)	1 → many	XIV(381480-382202)

ENSEMBL Gene Tree for NMRK2 (if available)
TreeFam Gene Tree for NMRK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NMRK2 gene

NMRK1²

2 SIMAP similar genes for NMRK2 using alignment to 3 protein entries: NRK2_HUMAN (see all proteins):

ITGB1BP3 NMRK1

NMRK2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200114937^1,2	C	untested¹	3942105(+)	`GTCCCA/GAGAGG`	2	Q R	mis¹		0	--	--	--	--
rs4807535^1,2	C,F,H	--	3931177(+)	`CTTCCC/TGCCGG`	1	--	us2k¹ trp³		25		NS EA NA WA CSA	2350
rs181251291^1,2		--	3931241(+)	`GGGCAC/TGTCAC`	1	--	us2k¹		0	--	--	--	--
rs28497308^1,2	C,F,H	--	3931269(+)	`GGCCAC/TGTGCC`	1	--	us2k¹ tfbs³		12		NS NA WA	1552
rs183526669^1,2		--	3931279(+)	`CCCACC/GAAGAG`	1	--	us2k¹		0	--	--	--	--
rs375609797^1,2	C	--	3931433(+)	`ACTGC-/TTTTTC`	1	--	us2k¹		0	--	--	--	--
rs188065609^1,2	C	--	3931545(+)	`TTGGTC/TGGGCG`	1	--	us2k¹		0	--	--	--	--
rs141257491^1,2		--	3931644(+)	`TGTAAA/CAAGAC`	1	--	us2k¹		0	--	--	--	--
rs10404963^1,2	C,H	--	3931794(+)	`TTCCCA/CCTTTT`	1	--	us2k¹		5		NS EA NA	416
rs116987495^1,2	C,F	--	3931946(+)	`GAGAGG/ACGTCA`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for NMRK2 (3933101 - 3942414 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for NMRK2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NMRK2

DNA2.0 Custom Variant and Variant Library Synthesis for NMRK2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NMRK2 for disorders About MalaCards
OMIM gene information: 608705 OMIM disorders: --

NMRK2 for disorders About GeneDecksing

Export disorders for NMRK2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NMRK2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with NMRK2)

Utopia: connect your pdf to the dynamic
world of online information

A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation. (PubMed id 10613898)^{1, 2, 3, 9} Li J.... Wu C. (1999)
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PubMed id 15137942)^{1, 2, 3} Bieganowski P. and Brenner C. (2004)
The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. (PubMed id 12941630)^{1, 2, 9} Li J.... Wu C. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Nicotinamide riboside kinase structures reveal new pathways to NAD+. (PubMed id 17914902)² Tempel W.... Brenner C. (2007)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. (PubMed id 12809483)¹ Battle M.A.... McCormick J.J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 27231	HGNC: 17871	AceView: ITGB1BP3	Ensembl:ENSG00000077009	euGenes: HUgn27231
ECgene: NMRK2	Kegg: 27231	H-InvDB: NMRK2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NMRK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NMRK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NMRK2 gene:
Search GeneIP for patents involving NMRK2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for NMRK2
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for NMRK2
	OriGene qSTAR qPCR primer pairs in human, mouse for NMRK2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for NMRK2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NMRK2		OriGene Custom Protein Services for NMRK2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NMRK2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NMRK2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMRK2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NMRK2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NMRK2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NMRK2

	GenScript Custom Purified and Recombinant Proteins Services for NMRK2		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NMRK2
	GenScript Custom Assay Services for NMRK2		GenScript Custom Superior Antibodies Services for NMRK2
	GenScript Custom overexpressing Cell Line Services for NMRK2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for NMRK2
	Search Chromatin IP Primers for NMRK2
	Search RT² qPCR Primer Assays in human, mouse, rat NMRK2
	Search GNC Networks for NMRK2
	SABiosciences Custom PCR Arrays for NMRK2

Search Tocris compounds for NMRK2 (NRK2)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NMRK2 antibodies
	NMRK2 proteins
	NMRK2 lysates

	Antibodies for NMRK2
	See all of Abcam's Antibodies, Kits and Proteins for NMRK2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Search LifeMap BioReagents cell lines for NMRK2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMRK2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for NMRK2
	SwitchGear Promoter luciferase reporter plasmids for NMRK2

ThermoFisher Antibodies for NMRK2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NMRK2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for NMRK2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NMRK2

Customized:

	lentivirus for stable overexpression of NMRK2
	lentivirus expression plasmids for stable overexpression of NMRK2
	adenovirus for overexpression of NMRK2

LSBio Antibodies in human, mouse, rat for NMRK2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NMRK2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

NMRK2 Gene

Nicotinamide Riboside Kinase 2

Aliases
for NMRK2 gene

Summaries
for NMRK2 gene

Genomic Views
for NMRK2 gene

Proteins
for NMRK2 gene

Protein Domains /
Families
for NMRK2 gene

Function
for NMRK2 gene

Pathways & Interactions
for NMRK2 gene

Drugs & Compounds
for NMRK2 gene

Transcripts
for NMRK2 gene

Expression
for NMRK2 gene

Orthologs
for NMRK2 gene

Paralogs
for NMRK2 gene

Genomic Variants
for NMRK2 gene

Disorders / Diseases
for NMRK2 gene

Publications
for NMRK2 gene

External Searches for NMRK2 gene

Genome Databases showing NMRK2 gene

Other Databases showing NMRK2 gene

Specialized Databases showing NMRK2 gene

Intellectual Property
for NMRK2 gene

Products
for NMRK2 gene

View Random Gene

Advanced Search

Export list of displayed genes

NMRK2 Gene

Nicotinamide Riboside Kinase 2

Aliasesfor NMRK2 gene

Summariesfor NMRK2 gene

Genomic Viewsfor NMRK2 gene

Proteinsfor NMRK2 gene

Protein Domains /Familiesfor NMRK2 gene

Functionfor NMRK2 gene

Pathways & Interactionsfor NMRK2 gene

Drugs & Compoundsfor NMRK2 gene

Transcriptsfor NMRK2 gene

Expression for NMRK2 gene

Orthologsfor NMRK2 gene

Paralogsfor NMRK2 gene

Genomic Variantsfor NMRK2 gene

Disorders / Diseasesfor NMRK2 gene

Publicationsfor NMRK2 gene

External Searches for NMRK2 gene

Genome Databases showing NMRK2 gene

Other Databases showing NMRK2 gene

Specialized Databases showing NMRK2 gene

Intellectual Propertyfor NMRK2 gene

Productsfor NMRK2 gene

View Random Gene

Aliases
for NMRK2 gene

Summaries
for NMRK2 gene

Genomic Views
for NMRK2 gene

Proteins
for NMRK2 gene

Protein Domains /
Families
for NMRK2 gene

Function
for NMRK2 gene

Pathways & Interactions
for NMRK2 gene

Drugs & Compounds
for NMRK2 gene

Transcripts
for NMRK2 gene

Expression
for NMRK2 gene

Orthologs
for NMRK2 gene

Paralogs
for NMRK2 gene

Genomic Variants
for NMRK2 gene

Disorders / Diseases
for NMRK2 gene

Publications
for NMRK2 gene

Intellectual Property
for NMRK2 gene

Products
for NMRK2 gene