Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NMRK2 Gene

Aliases for NMRK2 Gene

  • Nicotinamide Riboside Kinase 2 2 3 2
  • Muscle-Specific Beta 1 Integrin Binding Protein 2 3
  • Integrin Beta-1-Binding Protein 3 3 4
  • Nicotinic Acid Riboside Kinase 2 3 4
  • Ribosylnicotinic Acid Kinase 2 3 4
  • Ribosylnicotinamide Kinase 2 3 4
  • ITGB1BP3 3 4
  • NmR-K 2 3 4
  • NRK 2 3 4
  • RNK 2 3 4
  • MIBP 3 4
  • NRK2 3 4
  • Integrin Beta 1 Binding Protein 3 2
  • Muscle Integrin-Binding Protein 4
  • EC 2.7.1.173 4
  • EC 2.7.1.22 4

External Ids for NMRK2 Gene

Previous HGNC Symbols for NMRK2 Gene

  • ITGB1BP3

Summaries for NMRK2 Gene

GeneCards Summary for NMRK2 Gene

NMRK2 (Nicotinamide Riboside Kinase 2) is a Protein Coding gene. Among its related pathways are Nicotinate and nicotinamide metabolism and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include ribosylnicotinamide kinase activity. An important paralog of this gene is NMRK1.

UniProtKB/Swiss-Prot for NMRK2 Gene

  • Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.

Gene Wiki entry for NMRK2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMRK2 Gene

Genomics for NMRK2 Gene

Genomic Location for NMRK2 Gene

Start:
3,933,103 bp from pter
End:
3,942,416 bp from pter
Size:
9,314 bases
Orientation:
Plus strand

Genomic View for NMRK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMRK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMRK2 Gene

No data available for Regulatory Elements for NMRK2 Gene

Proteins for NMRK2 Gene

  • Protein details for NMRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI5-NRK2_HUMAN
    Recommended name:
    Nicotinamide riboside kinase 2
    Protein Accession:
    Q9NPI5
    Secondary Accessions:
    • B7ZKR3
    • Q52M81
    • Q9NZK3

    Protein attributes for NMRK2 Gene

    Size:
    230 amino acids
    Molecular mass:
    26046 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5.
    SequenceCaution:
    • Sequence=AAF26711.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for NMRK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMRK2 Gene

Proteomics data for NMRK2 Gene at MOPED

Post-translational modifications for NMRK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NMRK2 Gene

No data available for DME Specific Peptides for NMRK2 Gene

Domains for NMRK2 Gene

Protein Domains for NMRK2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NPI5

UniProtKB/Swiss-Prot:

NRK2_HUMAN :
  • Q9NPI5
Family:
  • Belongs to the uridine kinase family. NRK subfamily.
genes like me logo Genes that share domains with NMRK2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NMRK2 Gene

Function for NMRK2 Gene

Molecular function for NMRK2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.19 mM for nicotinamide riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=30 mM for nicotinamide riboside (with GTP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=0.11 mM for tiazofurin (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=0.063 mM for nicotinic acid riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902}; KM=1.3 mM for uridine (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide
UniProtKB/Swiss-Prot Function:
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.
UniProtKB/Swiss-Prot Induction:
Down-regulated during myoblast differentiation.

Enzyme Numbers (IUBMB) for NMRK2 Gene

Gene Ontology (GO) - Molecular Function for NMRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12809483
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0050262 ribosylnicotinamide kinase activity IEA --
genes like me logo Genes that share ontologies with NMRK2: view

Animal Model Products

CRISPR Products

miRNA for NMRK2 Gene

miRTarBase miRNAs that target NMRK2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMRK2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NMRK2 Gene

Localization for NMRK2 Gene

Gene Ontology (GO) - Cellular Components for NMRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with NMRK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NMRK2 Gene

Pathways for NMRK2 Gene

genes like me logo Genes that share pathways with NMRK2: view

Pathways by source for NMRK2 Gene

1 KEGG pathway for NMRK2 Gene
1 GeneGo (Thomson Reuters) pathway for NMRK2 Gene

UniProtKB/Swiss-Prot Q9NPI5-NRK2_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis

Gene Ontology (GO) - Biological Process for NMRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009435 NAD biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
GO:0045662 negative regulation of myoblast differentiation IEA --
genes like me logo Genes that share ontologies with NMRK2: view

Transcripts for NMRK2 Gene

Unigene Clusters for NMRK2 Gene

Nicotinamide riboside kinase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NMRK2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMRK2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1:
SP2: - -
SP3: - - - - -

Relevant External Links for NMRK2 Gene

GeneLoc Exon Structure for
NMRK2
ECgene alternative splicing isoforms for
NMRK2

Expression for NMRK2 Gene

mRNA expression in normal human tissues for NMRK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMRK2 Gene

This gene is overexpressed in Heart - Atrial Appendage (24.3), Heart - Left Ventricle (20.8), and Muscle - Skeletal (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NMRK2 Gene

SOURCE GeneReport for Unigene cluster for NMRK2 Gene Hs.135458

mRNA Expression by UniProt/SwissProt for NMRK2 Gene

Q9NPI5-NRK2_HUMAN
Tissue specificity: Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta.
genes like me logo Genes that share expressions with NMRK2: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for NMRK2 Gene

Orthologs for NMRK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NMRK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITGB1BP3 35
  • 90.43 (n)
  • 90.26 (a)
ITGB1BP3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmrk2 35
  • 83.25 (n)
  • 85.13 (a)
Nmrk2 16
Nmrk2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NMRK2 35
  • 98.94 (n)
  • 99.1 (a)
NMRK2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmrk2 35
  • 83.25 (n)
  • 84.1 (a)
oppossum
(Monodelphis domestica)
Mammalia NMRK2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMRK2 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858798 35
  • 79.32 (n)
  • 74.68 (a)
NMRK2 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6863 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
mibp 35
  • 67.01 (n)
  • 67.01 (a)
mibp 36
  • 64 (a)
OneToMany
nmrk2 36
  • 65 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.717 35
fruit fly
(Drosophila melanogaster)
Insecta CG12016 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for NMRK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMRK2 Gene

ENSEMBL:
Gene Tree for NMRK2 (if available)
TreeFam:
Gene Tree for NMRK2 (if available)

Paralogs for NMRK2 Gene

Paralogs for NMRK2 Gene

Selected SIMAP similar genes for NMRK2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NMRK2: view

Variants for NMRK2 Gene

Sequence variations from dbSNP and Humsavar for NMRK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1055767 -- 3,942,350(+) AGGGA(C/T)TGAGC utr-variant-3-prime, nc-transcript-variant
rs2304190 -- 3,933,171(+) CGGGC(A/G)GGGGT utr-variant-5-prime, nc-transcript-variant, upstream-variant-2KB
rs2304191 -- 3,933,234(+) GGCCA(C/T)AGGAC intron-variant, upstream-variant-2KB
rs2304192 -- 3,933,316(+) GGAAG(A/G)GGGTG intron-variant, upstream-variant-2KB
rs4806965 -- 3,935,381(+) ctccc(C/T)agtag intron-variant

Relevant External Links for NMRK2 Gene

HapMap Linkage Disequilibrium report
NMRK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NMRK2 Gene

Disorders for NMRK2 Gene

No disorders were found for NMRK2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NMRK2 Gene

Publications for NMRK2 Gene

  1. A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation. (PMID: 10613898) Li J. … Wu C. (J. Cell Biol. 1999) 2 3 4 23
  2. The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. (PMID: 12941630) Li J. … Wu C. (Dev. Biol. 2003) 3 4 23
  3. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PMID: 15137942) Bieganowski P. … Brenner C. (Cell 2004) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for NMRK2 Gene

Sources for NMRK2 Gene

Back to Top

Content