NMRK2 Gene
protein-coding GIFtS : 49 GCID: GC19 P003933
Nicotinamide Riboside Kinase 2 integrin beta 1 binding protein 3 )ITGB1BP3 )
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Aliasesfor NMRK2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Nicotinamide Riboside Kinase 2 1 2 Ribosylnicotinamide Kinase 22 3 ITGB1BP31 2 3 Ribosylnicotinic Acid Kinase 22 3 Integrin Beta 1 Binding Protein 31 2 MIBP2 3 Muscle-Specific Beta 1 Integrin Binding Protein1 2 NRK22 3 Integrin Beta-1-Binding Protein 32 3 NRK 22 3 Muscle Integrin-Binding Protein2 3 RNK 22 3 Nicotinic Acid Riboside Kinase 22 3 EC 2.7.1.1733 NmR-K 22 3 EC 2.7.1.223
Export aliases for NMRK2 gene to outside databases
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Summariesfor NMRK2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section GeneCards Summary for NMRK2 Gene: NMRK2 (nicotinamide riboside kinase 2) is a protein-coding gene. Among its related super-pathways are NAD metabolism and NAD salvage pathway III . GO annotations related to this gene include ribosylnicotinamide kinase activity and metal ion binding . An important paralog of this gene is NMRK1 . UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5 Function : Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to formnicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis Gene Wiki entry for NMRK2 (ITGB1BP3) Gene
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Genomic Viewsfor NMRK2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NT_011255.14 NC_018930.2 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for NMRK2 Other transcription factors Search SABiosciences Chromatin IP Primers for NMRK2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMRK2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3 NMRK2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P003933: view genomic region
(about GC identifiers )
Start: 3,933,101 bp from pter End:
3,942,414 bp from pter
Size: 9,314 bases Orientation:
plus strand
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Proteinsfor NMRK2 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5 See
protein sequence )Recommended Name: Size : 230 amino acids; 26046 DaSubunit : Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5Sequence caution : Sequence=AAF26711.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;Secondary accessions : Q52M81 Q9NZK3Explore the universe of human proteins at neXtProt for NMRK2: NX_Q9NPI5 Explore proteomics data for NMRK2 at MOPED Post-translational modifications:
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_Q9NPI5 NMRK2 Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins: NP_733778.1 ENSEMBL proteins: ENSP00000168977 ENSP00000471436 ENSP00000472581 ENSP00000468935 Human Recombinant Protein Products for NMRK2: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
IEA --
About GeneDecksing NMRK2 Antibody Products: Assay Products for NMRK2:
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Protein
Domains /for NMRK2 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section 1 InterPro protein domain :
Graphical View of Domain Structure for InterPro Entry Q9NPI5 ProtoNet protein and cluster: Q9NPI5
UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5 Similarity : Belongs to the uridine kinase family. NRK subfamilyAbout GeneDecksing
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Functionfor NMRK2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: NRK2_HUMAN, Q9NPI5 Function : Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to formnicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis Catalytic activity : ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotideCatalytic activity : ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotideBiophysicochemical properties : Kinetic parameters: KM=0.19 mM for nicotinamide riboside (with ATP as cosubstrate);KM=30 mM for nicotinamide riboside (with GTP as cosubstrate); KM=0.11 mM for tiazofurin (with ATP as cosubstrate); KM=0.063 mM for nicotinic acid riboside (with ATP as cosubstrate); KM=1.3 mM for uridine (with ATP as cosubstrate); Induction : Down-regulated during myoblast differentiation (By similarity) Enzyme Numbers (IUBMB): EC 2.7.1.22 1 EC 2.7.1.173 1
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 1 MGI phenotypic allele Nmrk2 (no phenotypes)About GeneDecksing Animal Models: Nmrk2 tm1(KOMP)Vlcg for NMRK2In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMRK2
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Pathways & Interactionsfor NMRK2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for NMRK2 About See pathways by source SuperPath Contained pathways About 1 NAD metabolism 2 Nicotinate metabolism
Pathways by source See SuperPaths Show all pathways 1 1 2 1 (Kegg details for NMRK2) :UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5 Pathway : Cofactor biosynthesis; NAD(+) biosynthesisAbout GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NMRK2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)5/13 Interacting proteins for NMRK2 (Q9NPI5 1 , 2 , 3 ENSP00000168977 4 via UniProtKB, MINT, STRING , and/or I2D (see all 13 )
About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0009435 NAD biosynthetic process
IEA -- GO:0045662 negative regulation of myoblast differentiation
IEA --
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Drugs & Compoundsfor NMRK2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
IUPHAR ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for NMRK2 (NRK2) NMRK2 / NRK2
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Transcriptsfor NMRK2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NMRK2 gene (2 alternative transcripts): NM_014446.1 NM_170678.2 Unigene Cluster for NMRK2:
Nicotinamide riboside kinase 2 Hs.135458 [show with all ESTs ] Unigene Representative Sequence: NM_170678 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000168977 (uc002lyz.4 uc010xia.2 ) ENST00000599576 ENST00000593949 ENST00000597889 Additional mRNA sequence: AF190819.1 AK001663.1 AK022514.1 AL365377.1 AY611481.1 BC093637.1 BC101575.1 BC143329.1
3 DOTS entries : DT.430745 DT.97836673
DT.100748647 24/34 AceView cDNA sequences (see all 34 ):
AY611481 AJ346155 AU154323 BM669267 BX280576 AL365377 AU132878 Z28616 AK001663 NM_170678 BM717225 AA722785 AJ346366 AA722719 AK022514 AI081312 AI160896 AJ707133 F19405 NM_014446 AF190819 Z24874 C04002 AI674785 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for NMRK2 About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 SP1 : SP2 : - - SP3 : - - - - -
ECgene alternative splicing isoforms for NMRK2
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Expression for NMRK2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NMRK2 expression in normal human tissues
(normalized intensities) NMRK2 embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: -- About this image
NMRK2 expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/4 selected tissues (see all 4 ) fully expand See NMRK2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NMRK2 SOURCE GeneReport for Unigene cluster: Hs.135458 UniProtKB/Swiss-Prot: NRK2_HUMAN, Q9NPI5 Tissue specificity : Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at proteinlevel). No expression in brain, kidney, liver, lung, pancreas nor placenta SABiosciences Custom PCR Arrays for NMRK2 Primer human mouse Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NMRK2 QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMRK2
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Orthologsfor NMRK2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for NMRK2 gene from 6/13 species (see all 13 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Nmrk21 5
integrin beta 1 binding protein 35 1
83.25(n) 1 85.13(a) 1
10 (39.72 cM) 5 69564 1 NM_027120.2 1 NP_081396.1 1 81198170 5
chicken Aves LOC1008587981
nicotinamide riboside kinase 2-like
79.11(n) 74.68(a)
100858798 XM_003642852.1 XP_003642900.1
African clawed frog Amphibia BX853350.12
--
74.51(n)
BX853350.1
zebrafish Actinopterygii BC050155.12
--
76.31(n)
64674 BC050155.1
fruit fly Insecta CG120166
--
20(a)
1 → many
3L(3319555-3322489)
baker's yeast Saccharomycetes NRK16
Nicotinamide riboside kinase, catalyzes the phosph... 17(a)
1 → many
XIV(381480-382202)
ENSEMBL Gene Tree for NMRK2 (if available)TreeFam Gene Tree for NMRK2 (if available)
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Paralogsfor NMRK2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for NMRK2 gene NMRK1 2 2 SIMAP similar genes for NMRK2 using alignment to 3 protein entries: NRK2_HUMAN (see all proteins ):ITGB1BP3 NMRK1 About GeneDecksing
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Genomic Variantsfor NMRK2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 19 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for NMRK2 (3933101 - 3942414 bp)
Structural Variations Database of Genomic Variants (DGV) variations for NMRK2: -- SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor NMRK2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About MalaCards About GeneDecksing OMIM gene information: 608705
OMIM disorders : --Export disorders for NMRK2 gene to outside databases
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Publicationsfor NMRK2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NMRK2 gene, integrated from 9 sources (see all 12 ):(articles sorted by number of sources associating them with NMRK2) Utopia : connect your pdf to the dynamic
A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation. (PubMed id 10613898) 1 , 2 , 3, 9(1999) Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PubMed id 15137942) 1 , 2 , 3(2004) The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition. (PubMed id 12941630) 1 , 2 , 9(2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 (2004) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 (2011) A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206) 1 (2011) Nicotinamide riboside kinase structures reveal new pathways to NAD+. (PubMed id 17914902) 2 (2007) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 (2005) ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. (PubMed id 12809483) 1 (2003)
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External Searches for NMRK2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NMRK2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NMRK2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing NMRK2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for NMRK2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NMRK2 gene: NMRK2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NMRK2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NMRK2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NMRK2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMRK2
ThermoFisher Antibodies for NMRK2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NMRK2
LSBio Antibodies in human mouse rat
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Aliases for NMRK2
Databases for NMRK2
Disorders / Diseases for NMRK2
Domains / Families for NMRK2
Drugs / Compounds for NMRK2
Expression for NMRK2
Function for NMRK2
Genomic Views for NMRK2
Intellectual Property for NMRK2
Orthologs for NMRK2
Paralogs for NMRK2
Pathways / Interactions for NMRK2
Products for NMRK2
Proteins for NMRK2
Publications for NMRK2
Search Box for NMRK2
Summaries for NMRK2
Transcripts for NMRK2
Variants for NMRK2
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GeneGo (Thomson Reuters) Pathway for NMRK2
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