Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NMRK1 Gene

Aliases for NMRK1 Gene

  • Nicotinamide Riboside Kinase 1 2 3 5
  • Nicotinic Acid Riboside Kinase 1 3 4
  • Ribosylnicotinic Acid Kinase 1 3 4
  • Ribosylnicotinamide Kinase 1 3 4
  • NmR-K 1 3 4
  • C9orf95 3 4
  • NRK 1 3 4
  • RNK 1 3 4
  • NRK1 3 4
  • Chromosome 9 Open Reading Frame 95 2
  • Ribosylnicotinamide Kinase 2
  • EC 4
  • EC 4
  • BA235O14.2 3

External Ids for NMRK1 Gene

Previous HGNC Symbols for NMRK1 Gene

  • C9orf95

Previous GeneCards Identifiers for NMRK1 Gene

  • GC09M077675

Summaries for NMRK1 Gene

Entrez Gene Summary for NMRK1 Gene

  • Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NMRK1 Gene

NMRK1 (Nicotinamide Riboside Kinase 1) is a Protein Coding gene. Among its related pathways are Metabolism and NAD metabolism. GO annotations related to this gene include kinase activity and ribosylnicotinamide kinase activity. An important paralog of this gene is NMRK2.

UniProtKB/Swiss-Prot for NMRK1 Gene

  • Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMRK1 Gene

Genomics for NMRK1 Gene

Regulatory Elements for NMRK1 Gene

Enhancers for NMRK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NMRK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NMRK1 Gene

75,060,573 bp from pter
75,088,319 bp from pter
27,747 bases
Minus strand

Genomic View for NMRK1 Gene

Genes around NMRK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMRK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMRK1 Gene

Proteins for NMRK1 Gene

  • Protein details for NMRK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nicotinamide riboside kinase 1
    Protein Accession:
    Secondary Accessions:
    • Q5W124
    • Q8N430

    Protein attributes for NMRK1 Gene

    199 amino acids
    Molecular mass:
    23193 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NMRK1 Gene

    Alternative splice isoforms for NMRK1 Gene


neXtProt entry for NMRK1 Gene

Proteomics data for NMRK1 Gene at MOPED

Post-translational modifications for NMRK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NMRK1 Gene

No data available for DME Specific Peptides for NMRK1 Gene

Domains & Families for NMRK1 Gene

Protein Domains for NMRK1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the uridine kinase family. NRK subfamily.
  • Belongs to the uridine kinase family. NRK subfamily.
genes like me logo Genes that share domains with NMRK1: view

No data available for Gene Families for NMRK1 Gene

Function for NMRK1 Gene

Molecular function for NMRK1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.088 mM for nicotinamide riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=0.068 mM for nicotinamide riboside (with GTP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=0.27 mM for tiazofurin (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=0.051 mM for nicotinic acid riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=17 mM for uridine (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; pH dependence: Optimum pH is 6.5-9. {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide.
UniProtKB/Swiss-Prot Function:
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.

Enzyme Numbers (IUBMB) for NMRK1 Gene

Gene Ontology (GO) - Molecular Function for NMRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0050262 ribosylnicotinamide kinase activity IEA --
genes like me logo Genes that share ontologies with NMRK1: view
genes like me logo Genes that share phenotypes with NMRK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NMRK1

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMRK1 Gene

Localization for NMRK1 Gene

Subcellular locations from

Jensen Localization Image for NMRK1 Gene COMPARTMENTS Subcellular localization image for NMRK1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NMRK1 Gene

Pathways & Interactions for NMRK1 Gene

genes like me logo Genes that share pathways with NMRK1: view

Pathways by source for NMRK1 Gene

1 GeneGo (Thomson Reuters) pathway for NMRK1 Gene

UniProtKB/Swiss-Prot Q9NWW6-NRK1_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis.

Gene Ontology (GO) - Biological Process for NMRK1 Gene


No data available for SIGNOR curated interactions for NMRK1 Gene

Drugs & Compounds for NMRK1 Gene

(2) Drugs for NMRK1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
NAD Pharma Full agonist, Agonist 0

(6) Additional Compounds for NMRK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
beta-nicotinamide D-ribonucleotide
Nicotinamide riboside
  • 1-(beta-D-Ribofuranosyl)nicotinamide
  • 1-b-D-Ribosyl-3-Pyridinecarboxamide
  • 1-beta-D-Ribosyl-3-Pyridinecarboxamide
  • 1-beta-delta-Ribosyl-3-Pyridinecarboxamide
  • 3-(Aminocarbonyl)-1-beta-D-ribofuranosyl-Pyridinium
nicotinate beta-D-ribonucleotide
Nicotinate D-ribonucleoside
  • D-Ribosylnicotinate
  • Nicotinate riboside
  • Nicotinic acid ribose
  • Nicotinic acid riboside
  • Ribosylnicotinate
genes like me logo Genes that share compounds with NMRK1: view

Transcripts for NMRK1 Gene

Unigene Clusters for NMRK1 Gene

Nicotinamide riboside kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMRK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - -

Relevant External Links for NMRK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NMRK1 Gene

mRNA expression in normal human tissues for NMRK1 Gene

Protein differential expression in normal tissues from HIPED for NMRK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4), Tlymphocyte (11.4), and Ovary (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMRK1 Gene

SOURCE GeneReport for Unigene cluster for NMRK1 Gene Hs.494186

genes like me logo Genes that share expression patterns with NMRK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NMRK1 Gene

Orthologs for NMRK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NMRK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NMRK1 35
  • 88.11 (n)
  • 85.43 (a)
NMRK1 36
  • 80 (a)
(Canis familiaris)
Mammalia NMRK1 35
  • 87.8 (n)
  • 85.57 (a)
NMRK1 36
  • 84 (a)
(Mus musculus)
Mammalia Nmrk1 35
  • 83.42 (n)
  • 81.03 (a)
Nmrk1 16
Nmrk1 36
  • 81 (a)
(Pan troglodytes)
Mammalia NMRK1 35
  • 98.66 (n)
  • 98.49 (a)
NMRK1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Nmrk1 35
  • 82.91 (n)
  • 81.54 (a)
(Monodelphis domestica)
Mammalia NMRK1 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia NMRK1 36
  • 75 (a)
(Gallus gallus)
Aves CZH9ORF95 35
  • 68.68 (n)
  • 63.32 (a)
NMRK1 36
  • 59 (a)
(Anolis carolinensis)
Reptilia NMRK1 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nmrk1 35
  • 65.28 (n)
  • 56.99 (a)
(Danio rerio)
Actinopterygii nmrk1 35
  • 58.69 (n)
  • 52.13 (a)
nmrk1 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006740 35
  • 48.37 (n)
  • 40.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12016 35
  • 48.93 (n)
  • 38.01 (a)
CG12016 36
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NRK1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for NMRK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMRK1 Gene

Gene Tree for NMRK1 (if available)
Gene Tree for NMRK1 (if available)

Paralogs for NMRK1 Gene

Paralogs for NMRK1 Gene

(2) SIMAP similar genes for NMRK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NMRK1: view

Variants for NMRK1 Gene

Sequence variations from dbSNP and Humsavar for NMRK1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs773154 -- 75,060,101(+) gacac(A/G)tgcac downstream-variant-500B
rs773155 -- 75,060,527(+) atggt(A/G)cacat downstream-variant-500B
rs773156 -- 75,061,050(+) GATCA(A/G)TATGT downstream-variant-500B, utr-variant-3-prime
rs773157 -- 75,061,062(+) TTTTA(A/T)AATTA downstream-variant-500B, utr-variant-3-prime
rs773158 -- 75,061,130(+) TGTAT(G/T)TATGT downstream-variant-500B, utr-variant-3-prime

Variation tolerance for NMRK1 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NMRK1 Gene

Disorders for NMRK1 Gene

Relevant External Links for NMRK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NMRK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMRK1 Gene

Publications for NMRK1 Gene

  1. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PMID: 15137942) Bieganowski P. … Brenner C. (Cell 2004) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Crystal structure of human nicotinamide riboside kinase. (PMID: 17698003) Khan J.A. … Tong L. (Structure 2007) 3
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3

Products for NMRK1 Gene

Sources for NMRK1 Gene