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Aliases for NMRK1 Gene

Aliases for NMRK1 Gene

  • Nicotinamide Riboside Kinase 1 2 3 5
  • Nicotinic Acid Riboside Kinase 1 3 4
  • Ribosylnicotinic Acid Kinase 1 3 4
  • Ribosylnicotinamide Kinase 1 3 4
  • NmR-K 1 3 4
  • C9orf95 3 4
  • NRK 1 3 4
  • RNK 1 3 4
  • NRK1 3 4
  • Chromosome 9 Open Reading Frame 95 2
  • Ribosylnicotinamide Kinase 2
  • EC 2.7.1.173 4
  • EC 2.7.1.22 4
  • BA235O14.2 3

External Ids for NMRK1 Gene

Previous HGNC Symbols for NMRK1 Gene

  • C9orf95

Previous GeneCards Identifiers for NMRK1 Gene

  • GC09M077675

Summaries for NMRK1 Gene

Entrez Gene Summary for NMRK1 Gene

  • Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NMRK1 Gene

NMRK1 (Nicotinamide Riboside Kinase 1) is a Protein Coding gene. Among its related pathways are Metabolism and NAD metabolism. GO annotations related to this gene include kinase activity and ribosylnicotinamide kinase activity. An important paralog of this gene is NMRK2.

UniProtKB/Swiss-Prot for NMRK1 Gene

  • Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.

Additional gene information for NMRK1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMRK1 Gene

Genomics for NMRK1 Gene

Regulatory Elements for NMRK1 Gene

Enhancers for NMRK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H075084 1.3 ENCODE dbSUPER 57.6 +0.8 772 5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 SP3 NMRK1 CARNMT1
GH09H075082 1.3 Ensembl ENCODE dbSUPER 57.4 +4.5 4528 2 ZFP64 ARID4B SIN3A RAD21 FOS SP5 CEBPB USF2 PPARG SREBF1 NMRK1 CARNMT1
GH09H075147 1.6 FANTOM5 Ensembl ENCODE dbSUPER 26.7 -62.0 -62022 6 HDAC1 GFI1B CEBPG REST ATF2 NR2F2 SREBF1 HDAC2 POLR2A ZNF24 NMRK1 RNU6-1228P OSTF1 LOC105376090
GH09H075110 0.9 Ensembl ENCODE dbSUPER 32.9 -23.1 -23056 1 PKNOX1 FOS NMRK1 OSTF1 CARNMT1 LOC105376090
GH09H075112 0.4 dbSUPER 63.5 -24.7 -24670 1 FOXA2 NMRK1 OSTF1 LOC105376090
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NMRK1 on UCSC Golden Path with GeneCards custom track

Promoters for NMRK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000236052 19 3401 PKNOX1 FOXA2 ARID4B SIN3A YY1 SLC30A9 ZNF766 ZNF207 SP3 SP5

Genomic Location for NMRK1 Gene

Chromosome:
9
Start:
75,060,573 bp from pter
End:
75,088,319 bp from pter
Size:
27,747 bases
Orientation:
Minus strand

Genomic View for NMRK1 Gene

Genes around NMRK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMRK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMRK1 Gene

Proteins for NMRK1 Gene

  • Protein details for NMRK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWW6-NRK1_HUMAN
    Recommended name:
    Nicotinamide riboside kinase 1
    Protein Accession:
    Q9NWW6
    Secondary Accessions:
    • Q5W124
    • Q8N430

    Protein attributes for NMRK1 Gene

    Size:
    199 amino acids
    Molecular mass:
    23193 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NMRK1 Gene

    Alternative splice isoforms for NMRK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMRK1 Gene

Post-translational modifications for NMRK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NMRK1 Gene

Domains & Families for NMRK1 Gene

Gene Families for NMRK1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NMRK1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NWW6

UniProtKB/Swiss-Prot:

NRK1_HUMAN :
  • Belongs to the uridine kinase family. NRK subfamily.
Family:
  • Belongs to the uridine kinase family. NRK subfamily.
genes like me logo Genes that share domains with NMRK1: view

Function for NMRK1 Gene

Molecular function for NMRK1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.088 mM for nicotinamide riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=0.068 mM for nicotinamide riboside (with GTP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=0.27 mM for tiazofurin (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=0.051 mM for nicotinic acid riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=17 mM for uridine (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; pH dependence: Optimum pH is 6.5-9. {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide.
UniProtKB/Swiss-Prot Function:
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.

Enzyme Numbers (IUBMB) for NMRK1 Gene

Gene Ontology (GO) - Molecular Function for NMRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NMRK1: view
genes like me logo Genes that share phenotypes with NMRK1: view

Animal Models for NMRK1 Gene

MGI Knock Outs for NMRK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NMRK1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NMRK1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMRK1 Gene

Localization for NMRK1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMRK1 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NMRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NMRK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NMRK1 Gene

Pathways & Interactions for NMRK1 Gene

genes like me logo Genes that share pathways with NMRK1: view

Pathways by source for NMRK1 Gene

UniProtKB/Swiss-Prot Q9NWW6-NRK1_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis.

Gene Ontology (GO) - Biological Process for NMRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009435 NAD biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
GO:0019363 pyridine nucleotide biosynthetic process IEA --
GO:0019674 NAD metabolic process TAS --
genes like me logo Genes that share ontologies with NMRK1: view

No data available for SIGNOR curated interactions for NMRK1 Gene

Drugs & Compounds for NMRK1 Gene

(2) Drugs for NMRK1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NAD Pharma Full agonist, Agonist 0
ATP Nutra Agonist 0

(6) Additional Compounds for NMRK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
beta-nicotinamide D-ribonucleotide
Nicotinamide riboside
  • 1-(beta-D-Ribofuranosyl)nicotinamide
  • 1-b-D-Ribosyl-3-Pyridinecarboxamide
  • 1-beta-D-Ribosyl-3-Pyridinecarboxamide
  • 1-beta-delta-Ribosyl-3-Pyridinecarboxamide
  • 3-(Aminocarbonyl)-1-beta-D-ribofuranosyl-Pyridinium
1341-23-7
nicotinate beta-D-ribonucleotide
Nicotinate D-ribonucleoside
  • D-Ribosylnicotinate
  • Nicotinate riboside
  • Nicotinic acid ribose
  • Nicotinic acid riboside
  • Ribosylnicotinate
genes like me logo Genes that share compounds with NMRK1: view

Transcripts for NMRK1 Gene

Unigene Clusters for NMRK1 Gene

Nicotinamide riboside kinase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NMRK1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NMRK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - -
SP10:
SP11:

Relevant External Links for NMRK1 Gene

GeneLoc Exon Structure for
NMRK1
ECgene alternative splicing isoforms for
NMRK1

Expression for NMRK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMRK1 Gene

Protein differential expression in normal tissues from HIPED for NMRK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4), Tlymphocyte (11.4), and Ovary (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NMRK1 Gene



NURSA nuclear receptor signaling pathways regulating expression of NMRK1 Gene:

NMRK1

SOURCE GeneReport for Unigene cluster for NMRK1 Gene:

Hs.494186

Evidence on tissue expression from TISSUES for NMRK1 Gene

  • Liver(4.3)
  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with NMRK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMRK1 Gene

Orthologs for NMRK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NMRK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMRK1 33 34
  • 98.66 (n)
cow
(Bos Taurus)
Mammalia NMRK1 33 34
  • 88.11 (n)
dog
(Canis familiaris)
Mammalia NMRK1 33 34
  • 87.8 (n)
mouse
(Mus musculus)
Mammalia Nmrk1 33 16 34
  • 83.42 (n)
rat
(Rattus norvegicus)
Mammalia Nmrk1 33
  • 82.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NMRK1 34
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMRK1 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9ORF95 33
  • 68.68 (n)
NMRK1 34
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMRK1 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmrk1 33
  • 65.28 (n)
zebrafish
(Danio rerio)
Actinopterygii nmrk1 33 34
  • 58.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12016 33 34
  • 48.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006740 33
  • 48.37 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NRK1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for NMRK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMRK1 Gene

ENSEMBL:
Gene Tree for NMRK1 (if available)
TreeFam:
Gene Tree for NMRK1 (if available)

Paralogs for NMRK1 Gene

Paralogs for NMRK1 Gene

(2) SIMAP similar genes for NMRK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NMRK1: view

Variants for NMRK1 Gene

Sequence variations from dbSNP and Humsavar for NMRK1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000011585 -- 75,089,091(+) CTTTA(A/G)CCACT intron-variant, upstream-variant-2KB
rs1000013149 -- 75,088,532(+) GCTCT(G/T)CCTGC upstream-variant-2KB, utr-variant-5-prime
rs1000070977 -- 75,082,810(+) CAGTG(C/T)CCAAT intron-variant
rs1000208529 -- 75,063,685(+) ACAAG(A/T)TTATG intron-variant
rs1000245505 -- 75,069,418(+) AGCTT(C/T)GAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NMRK1 Gene

Variant ID Type Subtype PubMed ID
nsv472236 CNV novel sequence insertion 20440878

Variation tolerance for NMRK1 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NMRK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMRK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMRK1 Gene

Disorders for NMRK1 Gene

Relevant External Links for NMRK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NMRK1

No disorders were found for NMRK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMRK1 Gene

Publications for NMRK1 Gene

  1. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PMID: 15137942) Bieganowski P … Brenner C (Cell 2004) 2 3 4 60
  2. Crystal structure of human nicotinamide riboside kinase. (PMID: 17698003) Khan JA … Tong L (Structure (London, England : 1993) 2007) 3 4 60
  3. Nicotinamide riboside kinase structures reveal new pathways to NAD+. (PMID: 17914902) Tempel W … Brenner C (PLoS biology 2007) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60

Products for NMRK1 Gene

Sources for NMRK1 Gene

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