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Aliases for NMRK1 Gene

Aliases for NMRK1 Gene

  • Nicotinamide Riboside Kinase 1 2 3
  • Nicotinic Acid Riboside Kinase 1 3 4
  • Ribosylnicotinic Acid Kinase 1 3 4
  • Ribosylnicotinamide Kinase 1 3 4
  • NmR-K 1 3 4
  • C9orf95 3 4
  • NRK 1 3 4
  • RNK 1 3 4
  • NRK1 3 4
  • Chromosome 9 Open Reading Frame 95 2
  • EC 2.7.1.173 4
  • EC 2.7.1.22 4
  • BA235O14.2 3

External Ids for NMRK1 Gene

Previous HGNC Symbols for NMRK1 Gene

  • C9orf95

Previous GeneCards Identifiers for NMRK1 Gene

  • GC09M077675

Summaries for NMRK1 Gene

Entrez Gene Summary for NMRK1 Gene

  • Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NMRK1 Gene

NMRK1 (Nicotinamide Riboside Kinase 1) is a Protein Coding gene. Among its related pathways are Nicotinate and nicotinamide metabolism and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include uridine kinase activity and ribosylnicotinamide kinase activity. An important paralog of this gene is NMRK2.

UniProtKB/Swiss-Prot for NMRK1 Gene

  • Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMRK1 Gene

Genomics for NMRK1 Gene

Genomic Location for NMRK1 Gene

Start:
75,060,573 bp from pter
End:
75,088,324 bp from pter
Size:
27,752 bases
Orientation:
Minus strand

Genomic View for NMRK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NMRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMRK1 Gene

No data available for Regulatory Elements for NMRK1 Gene

Proteins for NMRK1 Gene

  • Protein details for NMRK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWW6-NRK1_HUMAN
    Recommended name:
    Nicotinamide riboside kinase 1
    Protein Accession:
    Q9NWW6
    Secondary Accessions:
    • Q5W124
    • Q8N430

    Protein attributes for NMRK1 Gene

    Size:
    199 amino acids
    Molecular mass:
    23193 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NMRK1 Gene

    Alternative splice isoforms for NMRK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMRK1 Gene

Proteomics data for NMRK1 Gene at MOPED

Post-translational modifications for NMRK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NMRK1 Gene

No data available for DME Specific Peptides for NMRK1 Gene

Domains for NMRK1 Gene

Protein Domains for NMRK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWW6

UniProtKB/Swiss-Prot:

NRK1_HUMAN :
  • Q9NWW6
Family:
  • Belongs to the uridine kinase family. NRK subfamily.
genes like me logo Genes that share domains with NMRK1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NMRK1 Gene

Function for NMRK1 Gene

Molecular function for NMRK1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.088 mM for nicotinamide riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=0.068 mM for nicotinamide riboside (with GTP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=0.27 mM for tiazofurin (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=0.051 mM for nicotinic acid riboside (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; KM=17 mM for uridine (with ATP as cosubstrate) {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081}; pH dependence: Optimum pH is 6.5-9. {ECO:0000269 PubMed:17914902, ECO:0000269 PubMed:8809081};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide
UniProtKB/Swiss-Prot CatalyticActivity: ATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide
UniProtKB/Swiss-Prot Function: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.

Enzyme Numbers (IUBMB) for NMRK1 Gene

Gene Ontology (GO) - Molecular Function for NMRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0046872 metal ion binding IEA --
GO:0050262 ribosylnicotinamide kinase activity IEA --
genes like me logo Genes that share ontologies with NMRK1: view

miRNA for NMRK1 Gene

miRTarBase miRNAs that target NMRK1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NMRK1 Gene

Localization for NMRK1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NMRK1 Gene

Pathways for NMRK1 Gene

genes like me logo Genes that share pathways with NMRK1: view

Pathways by source for NMRK1 Gene

1 KEGG pathway for NMRK1 Gene
1 GeneGo (Thomson Reuters) pathway for NMRK1 Gene

UniProtKB/Swiss-Prot Q9NWW6-NRK1_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis

Gene Ontology (GO) - Biological Process for NMRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009435 NAD biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with NMRK1: view

Transcripts for NMRK1 Gene

Unigene Clusters for NMRK1 Gene

Nicotinamide riboside kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NMRK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - -
SP10:
SP11:

Relevant External Links for NMRK1 Gene

GeneLoc Exon Structure for
NMRK1
ECgene alternative splicing isoforms for
NMRK1

Expression for NMRK1 Gene

mRNA expression in normal human tissues for NMRK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NMRK1 Gene

SOURCE GeneReport for Unigene cluster for NMRK1 Gene Hs.494186

genes like me logo Genes that share expressions with NMRK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NMRK1 Gene

Orthologs for NMRK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NMRK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMRK1 35
  • 98.66 (n)
  • 98.49 (a)
NMRK1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NMRK1 35
  • 88.11 (n)
  • 85.43 (a)
NMRK1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NMRK1 35
  • 87.8 (n)
  • 85.57 (a)
NMRK1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nmrk1 35
  • 83.42 (n)
  • 81.03 (a)
Nmrk1 16
Nmrk1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NMRK1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMRK1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nmrk1 35
  • 82.91 (n)
  • 81.54 (a)
chicken
(Gallus gallus)
Aves CZH9ORF95 35
  • 68.68 (n)
  • 63.32 (a)
NMRK1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMRK1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nmrk1 35
  • 65.28 (n)
  • 56.99 (a)
zebrafish
(Danio rerio)
Actinopterygii nmrk1 35
  • 58.69 (n)
  • 52.13 (a)
nmrk1 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006740 35
  • 48.37 (n)
  • 40.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12016 35
  • 48.93 (n)
  • 38.01 (a)
CG12016 36
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NRK1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for NMRK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMRK1 Gene

ENSEMBL:
Gene Tree for NMRK1 (if available)
TreeFam:
Gene Tree for NMRK1 (if available)

Paralogs for NMRK1 Gene

Paralogs for NMRK1 Gene

Selected SIMAP similar genes for NMRK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NMRK1: view

Variants for NMRK1 Gene

Sequence variations from dbSNP and Humsavar for NMRK1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2273764 -- 75,082,310(+) GGAGG(A/C)AAAGC intron-variant
rs2273765 -- 75,082,610(+) GGTGC(A/C)TCCAG intron-variant
rs2273766 -- 75,082,715(+) CTGAA(G/T)CTGGG intron-variant
rs2273767 -- 75,083,013(+) TCCCC(C/G)ACTCC intron-variant
rs2273768 -- 75,083,350(+) TCAGG(A/C)CTGTC intron-variant, upstream-variant-2KB

Relevant External Links for NMRK1 Gene

HapMap Linkage Disequilibrium report
NMRK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NMRK1 Gene

Disorders for NMRK1 Gene

No disorders were found for NMRK1 Gene.

No data available for UniProtKB/Swiss-Prot for NMRK1 Gene

Publications for NMRK1 Gene

  1. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. (PMID: 15137942) Bieganowski P. … Brenner C. (Cell 2004) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Crystal structure of human nicotinamide riboside kinase. (PMID: 17698003) Khan J.A. … Tong L. (Structure 2007) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for NMRK1 Gene

Sources for NMRK1 Gene

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