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NMRAL1 Gene

protein-coding   GIFtS: 50
GCID: GC16M004512

NmrA-Like Family Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
NmrA-Like Family Domain Containing 11 2     SDR48A12
HSCARG2 3     NmrA-Like Family Domain-Containing Protein 12
Member 11     Short Chain Dehydrogenase/Reductase Family 48A, Member 12
Short Chain Dehydrogenase/Reductase Family 48A1     

External Ids:    HGNC: 249871   Entrez Gene: 574072   Ensembl: ENSG000001534067   UniProtKB: Q9HBL83   
ORGUL members:         

Export aliases for NMRAL1 gene to outside databases

Previous GC identifer: GC16M004452


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NMRAL1 Gene:
NMRAL1 (NmrA-like family domain containing 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: NMRL1_HUMAN, Q9HBL8
Function: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in
intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and
binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1
impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under
normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer
binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to
form a stable dimer




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NT_187608.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NMRAL1 gene promoter:
         AhR   E2F-3a   E2F-4   E2F-5   E2F-2   CREB   E2F-1   E2F   RSRFC4   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNMRAL1 promoter sequence
   Search Chromatin IP Primers for NMRAL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NMRAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

NMRAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMRAL1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004512:  view genomic region     (about GC identifiers)

Start:
4,511,681 bp from pter      End:
4,545,764 bp from pter
Size:
34,084 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NMRL1_HUMAN, Q9HBL8 (See protein sequence)
Recommended Name: NmrA-like family domain-containing protein 1  
Size: 299 amino acids; 33344 Da
Subunit: Homodimer. Interacts with ASS1. Interaction is enhanced by low NADPH/NADP(+) ratios, which results in
inhibition of ASS1 activity
Miscellaneous: Reduced levels of NMRAL1 by RNAi increases nitric oxide production and reduces cell viability.
Overexpression of NMRAL1 increases cell viability
Caution: Lacks the conserved Tyr residue in the active site triad of Ser-Tyr-Lys necessary for dehydrogenase
activity, suggesting that it has no oxidoreductase activity
5 PDB 3D structures from and Proteopedia for NMRAL1:
2EXX (3D)        2WM3 (3D)        2WMD (3D)        3DXF (3D)        3E5M (3D)    

Explore the universe of human proteins at neXtProt for NMRAL1: NX_Q9HBL8

Explore proteomics data for NMRAL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys31, Lys133, Lys167, Lys206, Lys230, Lys248, Lys281
  • Modification sites at PhosphoSitePlus

  • See NMRAL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065728.1  
    ENSEMBL proteins: 
     ENSP00000283429   ENSP00000458762   ENSP00000461763   ENSP00000459221   ENSP00000383962  
     ENSP00000460263   ENSP00000460837   ENSP00000460476   ENSP00000459926   ENSP00000459022  
     ENSP00000458425  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRA: Short chain dehydrogenase/reductase superfamily / Atypical members

    2 InterPro protein domains:
     IPR016040 NAD(P)-bd_dom
     IPR008030 NmrA

    Graphical View of Domain Structure for InterPro Entry Q9HBL8

    ProtoNet protein and cluster: Q9HBL8

    UniProtKB/Swiss-Prot: NMRL1_HUMAN, Q9HBL8
    Similarity: Belongs to the NmrA-type oxidoreductase family


    Find genes that share domains with NMRAL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NMRL1_HUMAN, Q9HBL8
    Function: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in
    intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and
    binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1
    impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under
    normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer
    binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to
    form a stable dimer
    Induction: By nitric oxide, cGMP and proinflammatory cytokines

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity ----
         
    Find genes that share ontologies with NMRAL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NMRAL1:
     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NMRAL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NMRAL1
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    Addgene plasmids for NMRAL1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NMRL1_HUMAN, Q9HBL8: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions
    localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular
    nitric oxide and reduced NADPH/NADP(+) ratios
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005730nucleolus ----
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with NMRAL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NMRAL1
    Interactions:

        Search GeneGlobe Interaction Network for NMRAL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NMRAL1 (ENSP000002834294) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFAB1ENSP000000075164STRING: ENSP00000007516
    NDUFS7ENSP000002336274STRING: ENSP00000233627
    UBCENSP000003448184STRING: ENSP00000344818
    FOXJ1ENSP000003238804STRING: ENSP00000323880
    PMPCAENSP000003607824STRING: ENSP00000360782
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006813potassium ion transport ----
    GO:0008152metabolic process ----

    Find genes that share ontologies with NMRAL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NMRAL1 (NMRL1)

    1 DrugBank Compound for NMRAL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NMRAL1 gene: 
    NM_020677.3  

    Unigene Cluster for NMRAL1:

    NmrA-like family domain containing 1
    Hs.288969  [show with all ESTs]
    Unigene Representative Sequence: BM458171
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283429(uc002cwo.3) ENST00000574733(uc002cwn.3) ENST00000571448
    ENST00000572232 ENST00000404295(uc002cwm.3) ENST00000574425 ENST00000572110
    ENST00000573533 ENST00000576176 ENST00000571291 ENST00000572391 ENST00000573520
    ENST00000573571 ENST00000575002 ENST00000575557 ENST00000576935 ENST00000575995
    ENST00000572559
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      QuantiTect SYBR Green Assays in human, mouse, rat NMRAL1
      QuantiFast Probe-based Assays in human, mouse, rat NMRAL1

    Additional mRNA sequence: 

    AF225419.1 AK098784.1 BC002927.2 BC007364.2 

    16 DOTS entries:

    DT.75105422  DT.100677718  DT.100816267  DT.95312856  DT.446751  DT.100816264  DT.100737452  DT.120676666 
    DT.95215789  DT.120676645  DT.100702406  DT.100816265  DT.95215803  DT.100036355  DT.40125288  DT.95073778 

    Selected AceView cDNA sequences (see all 217):

    BI793072 BU944032 BU634439 CR608452 T08490 CR606906 BM978613 CR622057 
    CB142918 BF724301 AW006467 CB053984 BX115709 AI783775 CA430801 AK098784 
    AL528210 BM912560 AI908114 BG222843 CD676285 CK820999 BE886955 BG396075 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NMRAL1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ·
    SP1:                                      -     -     -     -           -     -     -                 -                       -                 -               
    SP2:                                                  -     -           -     -     -                 -                       -                 -               
    SP3:                                                        -           -     -     -                 -                       -                 -               
    SP4:                                                        -                 -     -                 -                                                         
    SP5:                                                                                                                          -                                 

    ExUns: 12c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NMRAL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NMRAL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCGTTTCT
    NMRAL1 Expression
    About this image


    NMRAL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    NMRAL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NMRAL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288969
        Custom PCR Arrays for NMRAL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NMRAL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NMRAL1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nmral11 , 5 NmrA-like family domain containing 11, 5 81.83(n)1
    84.95(a)1
      16 (2.46 cM)5
    678241  NM_026393.11  NP_080669.11 
     47100595 
    chicken
    (Gallus gallus)
    Aves NMRAL11 NmrA-like family domain containing 1 70.72(n)
    64.86(a)
      416672  NM_001030645.1  NP_001025816.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.99982 Xenopus laevis transcribed sequence with weak similarity to protein refNP_065728.1 (H.sapiens) HSCARG protein [Homo sapiens] less 74.38(n)    CB559958.1 


    ENSEMBL Gene Tree for NMRAL1 (if available)
    TreeFam Gene Tree for NMRAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NMRAL1 gene
    1 SIMAP similar gene for NMRAL1 using alignment to 8 protein entries:     NMRL1_HUMAN (see all proteins):
    PLA2G15

    Find genes that share paralogs with NMRAL1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NMRAL1
    PGOHUM00000262438


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NMRAL1 (see all 331)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs133301341,2
    C,F--4494095(+) CTGTTT/GCCCGG 1 -- us2k12Minor allele frequency- G:0.20WA NA 238
    rs1913318971,2
    --4511247(+) ATGAAA/CGGGGT 1 -- int10--------
    rs1117492181,2
    C,F--4511332(+) GGGAAC/TAGAGG 1 -- int12Minor allele frequency- T:0.02NA 122
    rs745047001,2
    C,F--4511357(+) TGTTCT/CGCTAG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1424674471,2
    --4511405(+) AAACAC/TGTTTA 1 -- int10--------
    rs711396331,2
    C--4511558(+) CCCCC-/CGCTCC 1 -- int12Minor allele frequency- C:0.25NA 4
    rs1148881341,2
    F--4511565(+) CCCCCC/GCCCCG 1 -- int11Minor allele frequency- G:0.06WA 118
    rs1828217521,2
    --4511601(+) AGCCCC/TGGACC 1 -- int10--------
    rs1482062521,2
    --4511614(+) CCCCAA/GCCACT 1 -- int10--------
    rs2005346341,2
    C--4511743(+) TCTGGA/TGCCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NMRAL1 (4511681 - 4545764 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NMRAL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833132CNV Loss17160897
    nsv905224CNV Loss21882294
    esv23732CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NMRAL1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with NMRAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NADPH is an allosteric regulator of HSCARG. (PubMed id 19254724)1, 2 Dai X....Zheng X. (J. Mol. Biol. 2009)
    2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    3. An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. (PubMed id 18263583)1, 2 Zhao Y.... Zheng X. (J. Biol. Chem. 2008)
    4. Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. (PubMed id 17496144)1, 2 Zheng X.... Luo M. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    5. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. HSCARG inhibits NADPH oxidase activity through regulation of the expression of p47phox. (PubMed id 23527155)1 Xiao W....Zheng X. (PLoS ONE 2013)
    8. A CRM1-dependent nuclear export signal controls nucleocytoplasmic translocation of HSCARG, which regulates NF-I_B activity. (PubMed id 22348310)1 Zhang M....Zheng X. (Traffic 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57407 HGNC: 24987 AceView: HSCARG Ensembl:ENSG00000153406 euGenes: HUgn57407
    ECgene: NMRAL1 H-InvDB: NMRAL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NMRAL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NMRAL1 gene:
    Search GeneIP for patents involving NMRAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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